Anna Fettiplace, John Marcinak, Michael Merz, Hui-Talia Zhang, Luciana Kikuchi, Arie Regev, Melissa Palmer, Don Rockey, Robert Fontana, Paul H. Hayashi, Hans L. Tillmann, Adrian M. Di Bisceglie, James H. Lewis
Drug-induced liver injury (DILI) is a major concern for oncology drugs in clinical practice and under development. Monitoring cancer patients for hepatotoxicity is challenging as these patients may have abnormal liver tests pre-treatment or on-study for many reasons including liver injury due to past oncology treatments, hepatic metastases, medical co-morbidities such as heart failure, and concomitant medications. At present, there are no regulatory guidelines or position papers that systematically address best practices pertaining to DILI detection, assessment and management in oncology patients.
药物性肝损伤（DILI）是临床实践中和研发中的肿瘤药物的一个主要问题。对癌症患者进行肝毒性监测具有挑战性，因为这些患者在治疗前或研究过程中可能会出现肝功能检测异常，原因有很多，包括既往肿瘤治疗导致的肝损伤、肝转移、心力衰竭等并发症以及同时服用药物。目前，还没有监管指南或立场文件系统地阐述有关肿瘤患者 DILI 检测、评估和管理的最佳实践。
{"title":"Review article: Recommendations for detection, assessment and management of suspected drug-induced liver injury during clinical trials in oncology patients","authors":"Anna Fettiplace, John Marcinak, Michael Merz, Hui-Talia Zhang, Luciana Kikuchi, Arie Regev, Melissa Palmer, Don Rockey, Robert Fontana, Paul H. Hayashi, Hans L. Tillmann, Adrian M. Di Bisceglie, James H. Lewis","doi":"10.1111/apt.18271","DOIUrl":"https://doi.org/10.1111/apt.18271","url":null,"abstract":"Drug-induced liver injury (DILI) is a major concern for oncology drugs in clinical practice and under development. Monitoring cancer patients for hepatotoxicity is challenging as these patients may have abnormal liver tests pre-treatment or on-study for many reasons including liver injury due to past oncology treatments, hepatic metastases, medical co-morbidities such as heart failure, and concomitant medications. At present, there are no regulatory guidelines or position papers that systematically address best practices pertaining to DILI detection, assessment and management in oncology patients.","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial: Advancing care in Crohn's disease—Time to standardise bowel preparation scales","authors":"Mohammad Shehab, Talat Bessissow","doi":"10.1111/apt.18269","DOIUrl":"https://doi.org/10.1111/apt.18269","url":null,"abstract":"This article is linked to Solitano et al papers. To view these articles, visit https://doi.org/10.1111/apt.18210 and https://doi.org/10.1111/apt.18288","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter: Association of myokines with disease progression and outcomes in patients with alcohol-associated liver disease","authors":"Jianyu Lv, Yize Ying, Chenfei Du","doi":"10.1111/apt.18238","DOIUrl":"https://doi.org/10.1111/apt.18238","url":null,"abstract":"This article is linked to Kaur et al papers. To view these articles, visit https://doi.org/10.1111/apt.18202 and https://doi.org/10.1111/apt.18279","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial: Advancing care in Crohn's disease—Time to standardise bowel preparation scales. Authors' reply","authors":"Virginia Solitano, Christopher Ma, Vipul Jairath","doi":"10.1111/apt.18288","DOIUrl":"https://doi.org/10.1111/apt.18288","url":null,"abstract":"This article is linked to Solitano et al papers. To view these articles, visit https://doi.org/10.1111/apt.18210 and https://doi.org/10.1111/apt.18269","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter: Association of myokines with disease progression and outcomes in patients with alcohol-associated liver disease—Authors' reply","authors":"Parminder Kaur, Nipun Verma","doi":"10.1111/apt.18279","DOIUrl":"https://doi.org/10.1111/apt.18279","url":null,"abstract":"This article is linked to Kaur et al papers. To view these articles, visit https://doi.org/10.1111/apt.18202 and https://doi.org/10.1111/apt.18238","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142247177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter: Enhancing gastric cancer prevention—The need for a comprehensive three-tier emergency management strategy","authors":"Zhangbin Zhou, Liu Wang, Yunfeng Chen","doi":"10.1111/apt.18260","DOIUrl":"https://doi.org/10.1111/apt.18260","url":null,"abstract":"This article is linked to Ligato et al papers. To view these articles, visit https://doi.org/10.1111/apt.17872 and https://doi.org/10.1111/apt.18283","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This article is linked to Ferreiro-Iglesias et al papers. To view these articles, visit https://doi.org/10.1111/apt.18133 and https://doi.org/10.1111/apt.18281
{"title":"Letter: Ulcerative proctitis—A step towards addressing the knowledge gap, and a call for greater detail, in trial data","authors":"John David Chetwood, Nik Sheng Ding","doi":"10.1111/apt.18248","DOIUrl":"https://doi.org/10.1111/apt.18248","url":null,"abstract":"This article is linked to Ferreiro-Iglesias et al papers. To view these articles, visit https://doi.org/10.1111/apt.18133 and https://doi.org/10.1111/apt.18281","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter: Enhancing gastric cancer prevention—The need for a comprehensive three-tier emergency management strategy. Authors' reply","authors":"Irene Ligato, Bruno Annibale, Gianluca Esposito","doi":"10.1111/apt.18283","DOIUrl":"https://doi.org/10.1111/apt.18283","url":null,"abstract":"This article is linked to Ligato et al papers. To view these articles, visit https://doi.org/10.1111/apt.17872 and https://doi.org/10.1111/apt.18260","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rocío Ferreiro-Iglesias, Manuel Barreiro-de Acosta
This article is linked to Ferreiro-Iglesias et al papers. To view these articles, visit https://doi.org/10.1111/apt.18133 and https://doi.org/10.1111/apt.18248
{"title":"Letter: Ulcerative proctitis, a step towards addressing the knowledge gap, and a call for greater detail, in trial data—Authors' reply","authors":"Rocío Ferreiro-Iglesias, Manuel Barreiro-de Acosta","doi":"10.1111/apt.18281","DOIUrl":"https://doi.org/10.1111/apt.18281","url":null,"abstract":"This article is linked to Ferreiro-Iglesias et al papers. To view these articles, visit https://doi.org/10.1111/apt.18133 and https://doi.org/10.1111/apt.18248","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142246249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Chaparro, Sandra Hermida, Diana Acosta, Agnès Fernández-Clotet, Manuel Barreiro-de Acosta, Álvaro Hernández Martínez, Maite Arroyo, Marta Maia Bosca-Watts, M. Teresa Diz-Lois Palomares, Luis Menchén, Jesús Martínez Cadilla, Eduardo Leo-Carnerero, Carmen Muñoz Villafranca, Mónica Sierra-Ausín, Yago González-Lama, Sabino Riestra, Pau Sendra Rumbeu, M. José Cabello Tapia, Irene García de la Filia, Raquel Vicente, Daniel Ceballos, Ramón Pajares Villarroya, Patricia Ramírez de la Piscina, María Dolores Martín-Arranz, Laura Ramos, Alexandra Ruiz-Cerulla, Teresa de Jesús Martínez-Pérez, Elena San Miguel Amelivia, Xavier Calvet, José María Huguet, Alma Keco-Huerga, Rufo H. Lorente Poyatos, José Fernando Muñoz, Ángel Ponferrada-Díaz, Beatriz Sicilia, Pedro Delgado-Guillena, Elena Gómez Delgado, Francisco J. Rancel-Medina, Horacio Alonso-Galán, Belén Herreros, Montserrat Rivero, Pilar Varela, Fernando Bermejo, Marifé García Sepulcre, Leticia Gimeno-Pitarch, Lilyan Kolle-Casso, Lucía Márquez-Mosquera, Pilar Martínez Tirado, Cynthia Ramírez, Eva Sesé Abizanda, Carmen Dueñas Sadornil, Hipólito Fernández Rosáenz, Ana Gutiérrez Casbas, Rosa Eva Madrigal Domínguez, Óscar Nantes Castillejo, Yolanda Ber Nieto, Belén Botella Mateu, Santiago Frago Larramona, Pilar López Serrano, José María Rubio Mateos, Sandra Torrá Alsina, Eduardo Iyo, José Luis Fernández Forcelledo, Luis Hernández, María Carmen Rodríguez-Grau, David Monfort Miquel, Manuel Van Domselaar, Carmen López Ramos, M. Jesús Ruiz Barcia, Javier P. Gisbert
Ustekinumab is approved for ulcerative colitis (UC).
Ustekinumab 获准用于治疗溃疡性结肠炎（UC）。
{"title":"Long-term benefit of ustekinumab in ulcerative colitis in clinical practice: ULISES study","authors":"María Chaparro, Sandra Hermida, Diana Acosta, Agnès Fernández-Clotet, Manuel Barreiro-de Acosta, Álvaro Hernández Martínez, Maite Arroyo, Marta Maia Bosca-Watts, M. Teresa Diz-Lois Palomares, Luis Menchén, Jesús Martínez Cadilla, Eduardo Leo-Carnerero, Carmen Muñoz Villafranca, Mónica Sierra-Ausín, Yago González-Lama, Sabino Riestra, Pau Sendra Rumbeu, M. José Cabello Tapia, Irene García de la Filia, Raquel Vicente, Daniel Ceballos, Ramón Pajares Villarroya, Patricia Ramírez de la Piscina, María Dolores Martín-Arranz, Laura Ramos, Alexandra Ruiz-Cerulla, Teresa de Jesús Martínez-Pérez, Elena San Miguel Amelivia, Xavier Calvet, José María Huguet, Alma Keco-Huerga, Rufo H. Lorente Poyatos, José Fernando Muñoz, Ángel Ponferrada-Díaz, Beatriz Sicilia, Pedro Delgado-Guillena, Elena Gómez Delgado, Francisco J. Rancel-Medina, Horacio Alonso-Galán, Belén Herreros, Montserrat Rivero, Pilar Varela, Fernando Bermejo, Marifé García Sepulcre, Leticia Gimeno-Pitarch, Lilyan Kolle-Casso, Lucía Márquez-Mosquera, Pilar Martínez Tirado, Cynthia Ramírez, Eva Sesé Abizanda, Carmen Dueñas Sadornil, Hipólito Fernández Rosáenz, Ana Gutiérrez Casbas, Rosa Eva Madrigal Domínguez, Óscar Nantes Castillejo, Yolanda Ber Nieto, Belén Botella Mateu, Santiago Frago Larramona, Pilar López Serrano, José María Rubio Mateos, Sandra Torrá Alsina, Eduardo Iyo, José Luis Fernández Forcelledo, Luis Hernández, María Carmen Rodríguez-Grau, David Monfort Miquel, Manuel Van Domselaar, Carmen López Ramos, M. Jesús Ruiz Barcia, Javier P. Gisbert","doi":"10.1111/apt.18230","DOIUrl":"https://doi.org/10.1111/apt.18230","url":null,"abstract":"Ustekinumab is approved for ulcerative colitis (UC).","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":null,"pages":null},"PeriodicalIF":7.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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