Psoriasis is an inflammatory skin disease with characteristic changes in the epidermis that resembles unsuppressed wound healing due to excessive hyperproliferation of keratinocytes. The keratinocyte hyperproliferation is also accompanied by abnormal differentiation of cells. It is not clear how much keratinocytes contribute to disease pathology. In this article, the authors, however, attempt to summarize data that argue for the importance of abnormal keratinocyte behavior in the pathomechanism of psoriatic skin lesions.
{"title":"The psoriatic keratinocytes","authors":"Z. Bata-Csorgo, M. Széll","doi":"10.1586/EDM.12.48","DOIUrl":"https://doi.org/10.1586/EDM.12.48","url":null,"abstract":"Psoriasis is an inflammatory skin disease with characteristic changes in the epidermis that resembles unsuppressed wound healing due to excessive hyperproliferation of keratinocytes. The keratinocyte hyperproliferation is also accompanied by abnormal differentiation of cells. It is not clear how much keratinocytes contribute to disease pathology. In this article, the authors, however, attempt to summarize data that argue for the importance of abnormal keratinocyte behavior in the pathomechanism of psoriatic skin lesions.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80385445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapy of cutaneous manifestations of tuberculosis in Saudi Arabia","authors":"I. Bukhari","doi":"10.1586/EDM.12.50","DOIUrl":"https://doi.org/10.1586/EDM.12.50","url":null,"abstract":"","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73429802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Skin cancer remains the most frequently diagnosed cancer around the world. In particular, we are challenged by melanoma, the most frequent cause of death from skin cancer, and compared with all other cancers, one that often affects younger individuals. It is estimated that at least 9000 individuals will die from melanoma in the USA and in Australia in 2012; it is the fourth most common cancer overall. Earlier intervention and detection have had promising effects on mortality, but not at a satisfactory rate. The authors will review the newest developments in detection and awareness of skin cancer with a focus on melanoma. Much work remains to be done to improve our ability to prevent this cancer before it reaches a fatal stage.
{"title":"Improvements and continued challenges in the early detection of skin cancers","authors":"K. Nguyen, A. Geller, Jennifer Y. Lin","doi":"10.1586/EDM.12.46","DOIUrl":"https://doi.org/10.1586/EDM.12.46","url":null,"abstract":"Skin cancer remains the most frequently diagnosed cancer around the world. In particular, we are challenged by melanoma, the most frequent cause of death from skin cancer, and compared with all other cancers, one that often affects younger individuals. It is estimated that at least 9000 individuals will die from melanoma in the USA and in Australia in 2012; it is the fourth most common cancer overall. Earlier intervention and detection have had promising effects on mortality, but not at a satisfactory rate. The authors will review the newest developments in detection and awareness of skin cancer with a focus on melanoma. Much work remains to be done to improve our ability to prevent this cancer before it reaches a fatal stage.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81988335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermoscopy has dramatically developed, becoming a well-established routine technique in many countries in the mid-1980s. Dermoscopy allows physicians to observe structures and colors otherwise not visible to unaided eyes, increasing melanoma diagnostic accuracy by up to 35%. Moreover, dermoscopy allows for increases in the number of diagnosed and excised melanomas together with a reduction in the number of unnecessary excisions. New data are continuously acquired mostly on melanoma diagnosis, follow-up of melanocytic lesions and nevogenesis. Short-term 3-month follow-up is the optimum time interval for identifying minimal changes in featureless melanomas. Nevertheless, long-term follow-up is similarly useful for the recognition of changes in melanomas with very low rates of growth. In the last few years a huge number of publications on dermoscopy have been published. The aim of this review is to summarize the most important recent advances in dermoscopy.
{"title":"Dermoscopy: distinguishing malignant tumors from benign","authors":"Andrea Gulia, A. Brunasso, C. Massone","doi":"10.1586/EDM.12.47","DOIUrl":"https://doi.org/10.1586/EDM.12.47","url":null,"abstract":"Dermoscopy has dramatically developed, becoming a well-established routine technique in many countries in the mid-1980s. Dermoscopy allows physicians to observe structures and colors otherwise not visible to unaided eyes, increasing melanoma diagnostic accuracy by up to 35%. Moreover, dermoscopy allows for increases in the number of diagnosed and excised melanomas together with a reduction in the number of unnecessary excisions. New data are continuously acquired mostly on melanoma diagnosis, follow-up of melanocytic lesions and nevogenesis. Short-term 3-month follow-up is the optimum time interval for identifying minimal changes in featureless melanomas. Nevertheless, long-term follow-up is similarly useful for the recognition of changes in melanomas with very low rates of growth. In the last few years a huge number of publications on dermoscopy have been published. The aim of this review is to summarize the most important recent advances in dermoscopy.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89074466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trichoscopy is hair and scalp dermoscopy using a handheld dermoscope or polarized light video microscope. This article shows the revised trichoscopic algorithm for common hair loss diseases. For the algorithm for cicatricial alopecia, loss of orifices, micropustules and/or hair tufting with six or more hairs should be carefully observed. When loss of hair orifices cannot be seen in the hair loss area, diagnosis as noncicatricial alopecia is established. Among noncicatricial alopecia, alopecia areata is most commonly encountered and should be mainly considered for differential diagnosis. Therefore, the first check point is yellow dots, black dots or broken hairs. The hallmark of androgenetic alopecia and tinea capitis is hair diameter diversity (≥20%) and comma hairs, respectively. Hair shaft abnormalities can be diagnosed from the characteristics of trichoscopy reported until now.
{"title":"Trichoscopy: a new frontier for the diagnosis of hair diseases","authors":"S. Inui","doi":"10.1586/EDM.12.40","DOIUrl":"https://doi.org/10.1586/EDM.12.40","url":null,"abstract":"Trichoscopy is hair and scalp dermoscopy using a handheld dermoscope or polarized light video microscope. This article shows the revised trichoscopic algorithm for common hair loss diseases. For the algorithm for cicatricial alopecia, loss of orifices, micropustules and/or hair tufting with six or more hairs should be carefully observed. When loss of hair orifices cannot be seen in the hair loss area, diagnosis as noncicatricial alopecia is established. Among noncicatricial alopecia, alopecia areata is most commonly encountered and should be mainly considered for differential diagnosis. Therefore, the first check point is yellow dots, black dots or broken hairs. The hallmark of androgenetic alopecia and tinea capitis is hair diameter diversity (≥20%) and comma hairs, respectively. Hair shaft abnormalities can be diagnosed from the characteristics of trichoscopy reported until now.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84292476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Moreno-Coutiño, E. Vásquez-del-Mercado, R. Arenas
Onychomycosis is the most common nail disease. Its many different clinical manifestations should be addressed individually in order to select the most appropriate therapy. Treatment options are classified as systemic, topical or combined. This report is focused on the Mexican experience of how to select the best treatment option based on the patient characteristics.
{"title":"Treatment of onychomycosis in Mexico","authors":"G. Moreno-Coutiño, E. Vásquez-del-Mercado, R. Arenas","doi":"10.1586/EDM.12.29","DOIUrl":"https://doi.org/10.1586/EDM.12.29","url":null,"abstract":"Onychomycosis is the most common nail disease. Its many different clinical manifestations should be addressed individually in order to select the most appropriate therapy. Treatment options are classified as systemic, topical or combined. This report is focused on the Mexican experience of how to select the best treatment option based on the patient characteristics.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83465432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Complement bridges the innate and adaptive immune systems, recognizing and eliminating microorganisms and maintaining tissue homeostasis. Perturbations in the complement cascade can be of profound clinical consequence, with dermatological associations including impaired control of infectious agents, predisposition to autoimmune disease (notably systemic lupus erythematosus) and hereditary and acquired angioedema. In this review, the authors describe the fundamentals of the complement cascade and discuss the clinical manifestations of defects in signaling in order to contextualize the rational testing of complement components and functional assays in dermatological practice.
{"title":"The role of the complement system in dermatological disease","authors":"F. Ali, F. Al‐Niaimi","doi":"10.1586/EDM.12.31","DOIUrl":"https://doi.org/10.1586/EDM.12.31","url":null,"abstract":"Complement bridges the innate and adaptive immune systems, recognizing and eliminating microorganisms and maintaining tissue homeostasis. Perturbations in the complement cascade can be of profound clinical consequence, with dermatological associations including impaired control of infectious agents, predisposition to autoimmune disease (notably systemic lupus erythematosus) and hereditary and acquired angioedema. In this review, the authors describe the fundamentals of the complement cascade and discuss the clinical manifestations of defects in signaling in order to contextualize the rational testing of complement components and functional assays in dermatological practice.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78010967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Peters, R. Sabat, S. Philipp, Elke Helleiner, J. Kruse, W. Sterry
Chronic inflammatory skin diseases such as psoriasis vulgaris are widespread and stressful not only for the affected patients but also for our healthcare system. Environmental influences and immune malfunctions are among the most frequently discussed issues. Both are related to modulation of stress-axis function. However, the relevance of the relationship between chronic skin inflammation, neuroimmune regulation and stress remains unclear. Also, the question if an effective anti-inflammatory therapy combined with lifestyle changes can more efficiently open up pathogenic circuits is to be discussed. The aim of this review is therefore to dissect a model disease for chronic inflammation and neuroimmune regulation and to delineate the current knowledge on its psychoneuroimmunologic framework and treatment options within.
{"title":"Neuroimmunological links in dermatology: psoriasis as a model disease in stress research","authors":"E. Peters, R. Sabat, S. Philipp, Elke Helleiner, J. Kruse, W. Sterry","doi":"10.1586/EDM.12.36","DOIUrl":"https://doi.org/10.1586/EDM.12.36","url":null,"abstract":"Chronic inflammatory skin diseases such as psoriasis vulgaris are widespread and stressful not only for the affected patients but also for our healthcare system. Environmental influences and immune malfunctions are among the most frequently discussed issues. Both are related to modulation of stress-axis function. However, the relevance of the relationship between chronic skin inflammation, neuroimmune regulation and stress remains unclear. Also, the question if an effective anti-inflammatory therapy combined with lifestyle changes can more efficiently open up pathogenic circuits is to be discussed. The aim of this review is therefore to dissect a model disease for chronic inflammation and neuroimmune regulation and to delineate the current knowledge on its psychoneuroimmunologic framework and treatment options within.","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81602964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. A. Arrabal-Polo, M. Girón-Prieto, S. Arias-Santiago
{"title":"Why are men with premature alopecia at higher risk of benign prostatic hyperplasia? And what about prostate cancer?","authors":"M. A. Arrabal-Polo, M. Girón-Prieto, S. Arias-Santiago","doi":"10.1586/EDM.12.30","DOIUrl":"https://doi.org/10.1586/EDM.12.30","url":null,"abstract":"","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73938730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic interventions for Netherton syndrome","authors":"N. Xiang, W. Di","doi":"10.1586/EDM.12.27","DOIUrl":"https://doi.org/10.1586/EDM.12.27","url":null,"abstract":"","PeriodicalId":12255,"journal":{"name":"Expert Review of Dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84172299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：