ABSTRACT Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for diabetes. Here, we showed that banana starch administered to diabetic rats improved animal depressive-like behaviours of mood disorders. Four weeks of banana starch diet to high-sugar, high-fat, and STZ-induced diabetic rats lowered their blood insulin resistance, but increased their plasma HDL cholesterol and 5-HT levels, compared to the control groups of rats. The banana starch diet reconstructed the gut microbiota and increased their metabolite of butyrate, as well as increased the activity of superoxidase in diabetic rats. Furthermore, Banana starch intervention significantly increased the exhaustion time of the diabetic rats, and almost restored it to the normal state of control groups in their swimming and tail suspension tests. Together, our results indicated the modulation of the gut-microbiota-brain axis as a possible mechanism that enables the banana starch diet as a potential therapeutic way for diabetes-associated mood disorders.
{"title":"Banana starch intervention ameliorates diabetes-induced mood disorders via modulation of the gut microbiota-brain axis in diabetic rats","authors":"Yongliang Bai, Meiguo Xin, Junming Lin, Jing Xie, Roumin Lin, Zhenshan Peng, Jingwen Guo, Weidong Bai","doi":"10.1080/09540105.2022.2071846","DOIUrl":"https://doi.org/10.1080/09540105.2022.2071846","url":null,"abstract":"ABSTRACT Bananas (Musa spp.) enriched in resistant starch displayed multiple health benefits for diabetes. Here, we showed that banana starch administered to diabetic rats improved animal depressive-like behaviours of mood disorders. Four weeks of banana starch diet to high-sugar, high-fat, and STZ-induced diabetic rats lowered their blood insulin resistance, but increased their plasma HDL cholesterol and 5-HT levels, compared to the control groups of rats. The banana starch diet reconstructed the gut microbiota and increased their metabolite of butyrate, as well as increased the activity of superoxidase in diabetic rats. Furthermore, Banana starch intervention significantly increased the exhaustion time of the diabetic rats, and almost restored it to the normal state of control groups in their swimming and tail suspension tests. Together, our results indicated the modulation of the gut-microbiota-brain axis as a possible mechanism that enables the banana starch diet as a potential therapeutic way for diabetes-associated mood disorders.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"377 - 402"},"PeriodicalIF":3.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42046958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-13DOI: 10.1080/09540105.2022.2080187
D. Song, Weiwei Wang, Bingxu Chen, Aike Li, G. Song, Junlin Cheng, Lin Qiao, Ronghua Zhu, Y. Min
ABSTRACT This research was designed to assess the influence of a synbiotic – yucca extract compound preparation (MCC) on production performance, faecal microbiota and immune in laying hens. A total of 180, 27-week-old healthy Hy-Line Brown laying hens were divided into 2 treatments with 6 replicates (15 birds/per replicates), including control group (CN), and treatment group with 3.34 g MCC/kg diet (MCC). The results revealed that supplementation of MCC in diet resulted in a greater laying rate in hens. The concentrations of serum IL-2, IL-6 and TNF-α were lower than CN group, whereas the concentrations of IgG and IL-10 in serum were higher in the MCC group. Furthermore, at the genus levels, the abundance of Romboutsia, and Helicobacter was lower, however, the abundance of Lactobacillus was higher when the hens were fed MCC. Therefore, the addition of MCC positively impacted the production performance, immune and faecal microbial diversity of laying hens.
摘要本试验旨在研究合成丝兰提取物复合制剂(MCC)对蛋鸡生产性能、粪便微生物群和免疫功能的影响。选取180只27周龄健康海兰褐蛋鸡，分为2个处理，每6个重复(每个重复15只鸡)，即对照组(CN)和添加3.34 g MCC/kg饲粮的处理组(MCC)。结果表明，饲粮中添加MCC可提高蛋鸡产蛋率。MCC组大鼠血清IL-2、IL-6和TNF-α浓度低于CN组，血清IgG和IL-10浓度高于CN组。此外，在属水平上，饲喂MCC时，Romboutsia和Helicobacter的丰度较低，而Lactobacillus的丰度较高。由此可见，添加MCC对蛋鸡生产性能、免疫和粪便微生物多样性均有积极影响。
{"title":"Dietary supplemental synbiotic – yucca extract compound preparation modulates production performance, immune status and faecal microflora diversity in laying hens","authors":"D. Song, Weiwei Wang, Bingxu Chen, Aike Li, G. Song, Junlin Cheng, Lin Qiao, Ronghua Zhu, Y. Min","doi":"10.1080/09540105.2022.2080187","DOIUrl":"https://doi.org/10.1080/09540105.2022.2080187","url":null,"abstract":"ABSTRACT This research was designed to assess the influence of a synbiotic – yucca extract compound preparation (MCC) on production performance, faecal microbiota and immune in laying hens. A total of 180, 27-week-old healthy Hy-Line Brown laying hens were divided into 2 treatments with 6 replicates (15 birds/per replicates), including control group (CN), and treatment group with 3.34 g MCC/kg diet (MCC). The results revealed that supplementation of MCC in diet resulted in a greater laying rate in hens. The concentrations of serum IL-2, IL-6 and TNF-α were lower than CN group, whereas the concentrations of IgG and IL-10 in serum were higher in the MCC group. Furthermore, at the genus levels, the abundance of Romboutsia, and Helicobacter was lower, however, the abundance of Lactobacillus was higher when the hens were fed MCC. Therefore, the addition of MCC positively impacted the production performance, immune and faecal microbial diversity of laying hens.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"360 - 376"},"PeriodicalIF":3.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44842384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-25DOI: 10.1080/09540105.2022.2074968
J. Čelakovská, E. Čermáková, R. Vankova, C. Andrys, J. Krejsek
ABSTRACT The aim of our study is the evaluation of the relation between the sensitisation to molecular components of moulds and yeast and the occurrence of food hypersensitivity reactions in atopic dermatitis patients. The food reactions were confirmed in an open exposure test (history); the sensitisation to allergen reagents (molecular components) of moulds and yeast was confirmed with ALEX2 Allergy Explorer Multiplex examination. The relation between the sensitisation to molecular components of fungi and the food hypersensitivity reactions was evaluated with the use of Fisher’s exact test. One hundred atopic dermatitis patients were included in the study (48 men and 52 women with an average age of 40.9 years). In patients with reaction to hazelnuts, walnuts, peanuts, fish and egg, the significantly higher level of specific IgE to Asp f 3, Cla h 8, Alt a 6, Alt a 1, Mala s 6 and Asp f 6 was confirmed.
摘要本研究的目的是评估特应性皮炎患者对霉菌和酵母分子成分的敏感性与食物超敏反应发生之间的关系。食物反应在开放暴露试验（历史）中得到证实；通过ALEX2 Allergy Explorer Multiplex检查证实了对霉菌和酵母的过敏原试剂（分子组分）的致敏。用Fisher精确检验法评价了真菌对分子组分的致敏作用与食物超敏反应之间的关系。研究中包括100名特应性皮炎患者（48名男性和52名女性，平均年龄40.9岁）。在对榛子、核桃、花生、鱼和鸡蛋有反应的患者中，证实了对Asp f3、Cla h8、Alt a6、Alt a1、Mala s6和Asp f6的特异性IgE水平显著较高。
{"title":"Sensitisation to molecular components of fungi in atopic dermatitis patients, the relation to the occurrence of food hypersensitivity reactions","authors":"J. Čelakovská, E. Čermáková, R. Vankova, C. Andrys, J. Krejsek","doi":"10.1080/09540105.2022.2074968","DOIUrl":"https://doi.org/10.1080/09540105.2022.2074968","url":null,"abstract":"ABSTRACT The aim of our study is the evaluation of the relation between the sensitisation to molecular components of moulds and yeast and the occurrence of food hypersensitivity reactions in atopic dermatitis patients. The food reactions were confirmed in an open exposure test (history); the sensitisation to allergen reagents (molecular components) of moulds and yeast was confirmed with ALEX2 Allergy Explorer Multiplex examination. The relation between the sensitisation to molecular components of fungi and the food hypersensitivity reactions was evaluated with the use of Fisher’s exact test. One hundred atopic dermatitis patients were included in the study (48 men and 52 women with an average age of 40.9 years). In patients with reaction to hazelnuts, walnuts, peanuts, fish and egg, the significantly higher level of specific IgE to Asp f 3, Cla h 8, Alt a 6, Alt a 1, Mala s 6 and Asp f 6 was confirmed.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"328 - 345"},"PeriodicalIF":3.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49116082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-25DOI: 10.1080/09540105.2022.2076812
Cheng Liang, Yuxiang Ji, Jiyong Ma, Chundong Zhang, Hongwei Zhao
ABSTRACT Okadaic acid (OA), one of marine biotoxins produced by several species of dinoflagellates, can accumulate in marine animals. The consumption of OA-contaminated seafood can cause diarrhoeic shellfish poisoning. Many countries have established regulatory restriction to limit the level of OA in seafood. In the present study, we report a highly sensitive monoclonal antibody (mAb) against OA produced by a new immunogen. Two monoclonal hybridoma cell lines (M8 and M12) that producing mAb with the best sensitivity and specificity were obtained. The obtained mAb-M12 was used to develop an indirect competitive ELISA (icELISA) with 50% inhibition concentrations of 0.15 ng mL−1 and a working range of 0.02–2.74 ng mL−1. The developed icELISA was more sensitive than the previous reports. HPLC-MS confirmed the accuracy and the working range of icELISA, suggesting that the developed icELISA is suitable for the rapid detection of OA in oysters and green mussels.
冈田酸(OA)是几种鞭毛藻产生的海洋生物毒素之一，可在海洋动物体内积累。食用受oa污染的海鲜可导致腹泻性贝类中毒。许多国家已经建立了监管限制，以限制海鲜中OA的水平。在本研究中，我们报道了一种新的免疫原产生的针对OA的高敏感单克隆抗体(mAb)。获得了两株单克隆杂交瘤细胞株(M8和M12)产生单抗的最佳敏感性和特异性。利用获得的单抗- m12建立间接竞争ELISA (icELISA)， 50%抑制浓度为0.15 ng mL−1，工作范围为0.02 ~ 2.74 ng mL−1。开发的icELISA比以前的报道更敏感。HPLC-MS验证了icELISA的准确性和工作范围，表明所建立的icELISA适用于牡蛎和青贻贝中OA的快速检测。
{"title":"Development of a highly sensitive and specific monoclonal antibody-based immunoassay for detection of okadaic acid in oysters and green mussels","authors":"Cheng Liang, Yuxiang Ji, Jiyong Ma, Chundong Zhang, Hongwei Zhao","doi":"10.1080/09540105.2022.2076812","DOIUrl":"https://doi.org/10.1080/09540105.2022.2076812","url":null,"abstract":"ABSTRACT Okadaic acid (OA), one of marine biotoxins produced by several species of dinoflagellates, can accumulate in marine animals. The consumption of OA-contaminated seafood can cause diarrhoeic shellfish poisoning. Many countries have established regulatory restriction to limit the level of OA in seafood. In the present study, we report a highly sensitive monoclonal antibody (mAb) against OA produced by a new immunogen. Two monoclonal hybridoma cell lines (M8 and M12) that producing mAb with the best sensitivity and specificity were obtained. The obtained mAb-M12 was used to develop an indirect competitive ELISA (icELISA) with 50% inhibition concentrations of 0.15 ng mL−1 and a working range of 0.02–2.74 ng mL−1. The developed icELISA was more sensitive than the previous reports. HPLC-MS confirmed the accuracy and the working range of icELISA, suggesting that the developed icELISA is suitable for the rapid detection of OA in oysters and green mussels.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"346 - 359"},"PeriodicalIF":3.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44394336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT With advances in the study of the human microbiome, the fact that lactate is the smallest chiral molecule in nature has drawn attention. However, there have been few comparative studies on the classification of L-lactate and D-lactate. In this study, we investigated the safety and efficacy of D-lactate as an immunomodulator of food origin. In terms of safety evaluation, both lactates were found to promote cell proliferation and repair. D-lactate was well tolerated for 30 d at doses up to 2000 mg/kg in mice. In terms of immune function evaluation, unexpectedly, D-lactate was found to enhance immunity by increasing the immune organ index, ear swelling index, lymphocyte conversion rate, haemolysis rate and macrophage phagocytosis rate and had a dose-dependent effect. D-lactate showed stronger immune regulation effects than L-lactate. This study proves the safety and the immunoregulation capacity of D-lactate and provides a mechanistic basis for the bioactivity of fermented foods.
{"title":"Unexpected immunoregulation effects of D-lactate, different from L-lactate","authors":"Yongheng Yan, Ruijie Xu, Xiu-xia Li, Zhijie Yao, Hao Zhang, Haitao Li, Wei Chen","doi":"10.1080/09540105.2022.2068508","DOIUrl":"https://doi.org/10.1080/09540105.2022.2068508","url":null,"abstract":"ABSTRACT With advances in the study of the human microbiome, the fact that lactate is the smallest chiral molecule in nature has drawn attention. However, there have been few comparative studies on the classification of L-lactate and D-lactate. In this study, we investigated the safety and efficacy of D-lactate as an immunomodulator of food origin. In terms of safety evaluation, both lactates were found to promote cell proliferation and repair. D-lactate was well tolerated for 30 d at doses up to 2000 mg/kg in mice. In terms of immune function evaluation, unexpectedly, D-lactate was found to enhance immunity by increasing the immune organ index, ear swelling index, lymphocyte conversion rate, haemolysis rate and macrophage phagocytosis rate and had a dose-dependent effect. D-lactate showed stronger immune regulation effects than L-lactate. This study proves the safety and the immunoregulation capacity of D-lactate and provides a mechanistic basis for the bioactivity of fermented foods.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"286 - 301"},"PeriodicalIF":3.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45488406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT To improve the detection sensitivity of neomycin (NEO) in milk, we produced a sensitive monoclonal antibody (mAb) against NEO and developed a lateral flow immunoassay based on amorphous carbon nanoparticles (ACNPs-LFA). First, we conjugated NEO to carrier protein to prepare mAbs. We obtained six mAbs: mAb 1C6, mAb 1D3, mAb 2D3, mAb 4D5, mAb 5D1, and mAb 5H1. We characterised the mAbs by indirect competitive enzyme-linked immunosorbent assay and selected the most sensitive mAb based on the half-maximal inhibitory concentration (IC50). We selected mAb 4D5 (IC50 = 0.15 ng/mL) for the development of LFA. MAb 4D5 was labelled with ACNPs (ACNPs-mAb 4D5) by electrostatic absorption. Under optimised conditions, 5.4 μg mAb 4D5 coupling with 1 mL ACNPs, NEO-OVA at concentration of 80 μg/mL, 3 μL ACNPs-mAb 4D5 were used to develop LFA. The cut-off value was 8 ng/mL. Therefore, our developed ACNPs-LFA is suitable for on-site detection of NEO residues.
摘要为了提高牛奶中新霉素（NEO）的检测灵敏度，我们制备了一种针对NEO的敏感单克隆抗体（mAb），并开发了一种基于无定形碳纳米颗粒（ACNPs-LFA）的侧流免疫测定法。首先，我们将NEO与载体蛋白偶联以制备单克隆抗体。我们获得了六种mAb：mAb 1C6、mAb 1D3、mAb 2D3、mAb4D5、mAb 5D1和mAb 5H1。我们通过间接竞争性酶联免疫吸附测定法对mAb进行了表征，并根据半数最大抑制浓度（IC50）选择了最敏感的mAb。我们选择了mAb 4D5（IC50 = 0.15 ng/mL）用于LFA的发展。通过静电吸收用ACNPs（ACNPs MAb 4D5）标记MAb 4D5。在优化的条件下，5.4μg mAb 4D5与1 用80μg/mL浓度的ACNPs、NEO-OVA和3μL ACNPs mAb 4D5制备LFA。截止值为8 ng/mL。因此，我们开发的ACNPs LFA适用于近地天体残留物的现场检测。
{"title":"Development of a sensitive monoclonal antibody-based immunochromatographic strip for neomycin detection in milk","authors":"Kemeng Qin, Mingyue Ding, Chensi Zhang, Xijie Zhang, Yexuan Mao, Meng Dang, Zizhe Li, Youyi Wang, Shaohui Zhang, Yuhang Sun, Zhibin Zhang, Gaiming Zhao, Yu Li, Qian Li, Xiya Zhang","doi":"10.1080/09540105.2022.2070606","DOIUrl":"https://doi.org/10.1080/09540105.2022.2070606","url":null,"abstract":"ABSTRACT To improve the detection sensitivity of neomycin (NEO) in milk, we produced a sensitive monoclonal antibody (mAb) against NEO and developed a lateral flow immunoassay based on amorphous carbon nanoparticles (ACNPs-LFA). First, we conjugated NEO to carrier protein to prepare mAbs. We obtained six mAbs: mAb 1C6, mAb 1D3, mAb 2D3, mAb 4D5, mAb 5D1, and mAb 5H1. We characterised the mAbs by indirect competitive enzyme-linked immunosorbent assay and selected the most sensitive mAb based on the half-maximal inhibitory concentration (IC50). We selected mAb 4D5 (IC50 = 0.15 ng/mL) for the development of LFA. MAb 4D5 was labelled with ACNPs (ACNPs-mAb 4D5) by electrostatic absorption. Under optimised conditions, 5.4 μg mAb 4D5 coupling with 1 mL ACNPs, NEO-OVA at concentration of 80 μg/mL, 3 μL ACNPs-mAb 4D5 were used to develop LFA. The cut-off value was 8 ng/mL. Therefore, our developed ACNPs-LFA is suitable for on-site detection of NEO residues.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"315 - 327"},"PeriodicalIF":3.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47732539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-24DOI: 10.1080/09540105.2022.2070605
Lilia Konstantinovna Dobrodeeva, V. A. Shtaborov, N. P. Geshavets
ABSTRACT The questionnaire survey and the study of 1334 people living in the north of the European part of the Russian Federation, of which 970 are women and 364 are men, was conducted. 707 residents of the Arkhangelsk region and 627 residents of the Nenets Autonomous Okrug. The results of the questionnaire were analyzed depending on the appetite state (decreased -102 respondents, increased - 276, normal appetite – 1096, as well as dietary compliance – 124 and adherence to vegetarianism – 139). The most pronounced combined defects of immune protection (deficiency of phagocytic protection, deficiency of the content of natural killers and T-helpers) occur in people who have been eating mainly cereals and bread for a long time. Increased appetite in people over 55 years of age is associated with the frequency of chronic diseases of the gastrointestinal tract (35.7%) and increased tolerance to food antigens (52.3%).
{"title":"Immune background state among the residents of the north, depending on nutrition type","authors":"Lilia Konstantinovna Dobrodeeva, V. A. Shtaborov, N. P. Geshavets","doi":"10.1080/09540105.2022.2070605","DOIUrl":"https://doi.org/10.1080/09540105.2022.2070605","url":null,"abstract":"ABSTRACT The questionnaire survey and the study of 1334 people living in the north of the European part of the Russian Federation, of which 970 are women and 364 are men, was conducted. 707 residents of the Arkhangelsk region and 627 residents of the Nenets Autonomous Okrug. The results of the questionnaire were analyzed depending on the appetite state (decreased -102 respondents, increased - 276, normal appetite – 1096, as well as dietary compliance – 124 and adherence to vegetarianism – 139). The most pronounced combined defects of immune protection (deficiency of phagocytic protection, deficiency of the content of natural killers and T-helpers) occur in people who have been eating mainly cereals and bread for a long time. Increased appetite in people over 55 years of age is associated with the frequency of chronic diseases of the gastrointestinal tract (35.7%) and increased tolerance to food antigens (52.3%).","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"302 - 314"},"PeriodicalIF":3.0,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46448948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-23DOI: 10.1080/09540105.2022.2068507
Javeed Akhtar, Mebrhit Gebremariam Abrha
ABSTRACT High-pressure processing as a unique technique of meat preservation is being widely used to preserve the meat and meat products by which a commercially feasible product’s production is possible to meet the consumer’s demand with no chemical preservatives and other harmful substances. Pressure treatment could have effects on colour, texture, protein denaturation, and meat microbial stability at ambient or low temperatures; it can help in minimizing the thermal exposure of the meat product to prevent the quality degradation, reduce microbial contamination and improve tenderness. This paper briefly reviews the attention of the high-pressure processing influence on meat product quality, namely texture, tenderness, colour, and microbial. The principles, HPP equipment, challenges, and future trends in high-pressure processing are also discussed.
{"title":"Pressurization technique: principles and impact on quality of meat and meat products","authors":"Javeed Akhtar, Mebrhit Gebremariam Abrha","doi":"10.1080/09540105.2022.2068507","DOIUrl":"https://doi.org/10.1080/09540105.2022.2068507","url":null,"abstract":"ABSTRACT High-pressure processing as a unique technique of meat preservation is being widely used to preserve the meat and meat products by which a commercially feasible product’s production is possible to meet the consumer’s demand with no chemical preservatives and other harmful substances. Pressure treatment could have effects on colour, texture, protein denaturation, and meat microbial stability at ambient or low temperatures; it can help in minimizing the thermal exposure of the meat product to prevent the quality degradation, reduce microbial contamination and improve tenderness. This paper briefly reviews the attention of the high-pressure processing influence on meat product quality, namely texture, tenderness, colour, and microbial. The principles, HPP equipment, challenges, and future trends in high-pressure processing are also discussed.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"264 - 285"},"PeriodicalIF":3.0,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47951347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-18DOI: 10.1080/09540105.2022.2064435
W. Huang, Inhye Jeong, Bok-Kyung Han, M. J. Kim, Jiyoun Hong, S. Ahn, Wan Heo, J. Pan, Jae Kyeom Kim, Eui‐Cheol Shin, Y. J. Kim
ABSTRACT Chronic exposure to airborne particulate matter (PM) causes respiratory damage in humans owing to oxidative stress and inflammation. Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura (CZL) has been used in traditional medicine to treat several inflammatory diseases; however, studies on inflammatory pulmonary diseases are scarce. This study investigated the protective effects of CZL extract against PM10-induced lung injury in BALB/c mice. Cell type specific signaling pathways were explored using A549 and RAW264.7 cell lines. CZL extract noticeably attenuated PM10-induced lung injury and inflammatory cell infiltration in a mouse model. Protein markers, such as p-AKT, p-ERK, and p-NF-κB for PM10 induced lung inflammation were effectively reduced in CZL extract-treated mice and cells. Furthermore, CZL extracts considerably reduced the generation of reactive oxygen species and nitric oxide in cells. Collectively, CZL extract effectively reduced PM10-induced lung injury by suppressing pulmonary inflammation, potentially due to its anti-inflammatory and antioxidant properties.
长期暴露于空气中的颗粒物(PM)会引起氧化应激和炎症，从而导致人体呼吸系统损伤。菊花(zawadskii Herbich var. latilobum)Kitamura (CZL)已在传统医学中用于治疗几种炎症性疾病;然而，关于炎症性肺部疾病的研究很少。本研究探讨了CZL提取物对pm10诱导的BALB/c小鼠肺损伤的保护作用。以A549和RAW264.7细胞系为研究对象，探索细胞类型特异性信号通路。CZL提取物明显减轻pm10诱导的小鼠肺损伤和炎症细胞浸润。pakt、p-ERK和p-NF-κB等PM10诱导的肺部炎症蛋白标志物在CZL提取物处理的小鼠和细胞中有效降低。此外，CZL提取物显著减少了细胞中活性氧和一氧化氮的产生。总的来说，CZL提取物通过抑制肺部炎症有效地减少pm10诱导的肺损伤，可能是由于其抗炎和抗氧化特性。
{"title":"Chrysanthemum Zawadskii Herbich var. latilobum (Maxim.) Kitamura water extract prevents BALB/c mice lung injury from particulate matter 10 toxicity","authors":"W. Huang, Inhye Jeong, Bok-Kyung Han, M. J. Kim, Jiyoun Hong, S. Ahn, Wan Heo, J. Pan, Jae Kyeom Kim, Eui‐Cheol Shin, Y. J. Kim","doi":"10.1080/09540105.2022.2064435","DOIUrl":"https://doi.org/10.1080/09540105.2022.2064435","url":null,"abstract":"ABSTRACT Chronic exposure to airborne particulate matter (PM) causes respiratory damage in humans owing to oxidative stress and inflammation. Chrysanthemum zawadskii Herbich var. latilobum (Maxim.) Kitamura (CZL) has been used in traditional medicine to treat several inflammatory diseases; however, studies on inflammatory pulmonary diseases are scarce. This study investigated the protective effects of CZL extract against PM10-induced lung injury in BALB/c mice. Cell type specific signaling pathways were explored using A549 and RAW264.7 cell lines. CZL extract noticeably attenuated PM10-induced lung injury and inflammatory cell infiltration in a mouse model. Protein markers, such as p-AKT, p-ERK, and p-NF-κB for PM10 induced lung inflammation were effectively reduced in CZL extract-treated mice and cells. Furthermore, CZL extracts considerably reduced the generation of reactive oxygen species and nitric oxide in cells. Collectively, CZL extract effectively reduced PM10-induced lung injury by suppressing pulmonary inflammation, potentially due to its anti-inflammatory and antioxidant properties.","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"252 - 263"},"PeriodicalIF":3.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41824944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT We investigated the effects of carbon tetrachloride (CCl4) exposure on liver detoxification. We confirmed that 0.2%-0.8% CCl4 decreased the liver carboxylesterase (CarE), lactate dehydrogenase (LDH) activity and total protein (TP) levels, while 0.2% and 0.8% CCl4 increased the liver acetylcholine esterase (AChE) activity (P< 0.05). It was observed0.4%-0.8% CCl4 increased serum glutathione S-transferase (GST) and catalase (CAT) activity, 0.1%-0.8% CCl4 increased the level of malondialdehyde (MDA), and 0.2% CCl4 increased the level of total superoxide dismutase (T-SOD). The expression of nod-like receptor protein 3 (NLRP3), interleukin-1β (IL-1β), and tumour necrosis factor-α (TNF-α) were significantly elevated in 0.2%-0.8% CCl4 exposure (P< 0.05). The expression of p38MAPK, gasdermin D (GSDMD), and nuclear factor kappa-B kinase (IKK) was decreased in 0.1%-0.8% CCl4 exposure, while the apoptosis was not statistically different in all groups. This indicates that 0.1% CCl4 exposure could damage the liver structure and detoxification function via p38MAPK/NF-κB/NLRP3 pathway. GRAPHICAL ABSTRACT
{"title":"Environmental carbon tetrachloride exposure disrupts the liver structure and metabolic detoxification function in mice via p38MAPK/NF-κB/NLRP3 pathway","authors":"Yuanyuan Wei, Danyang Ma, Yimeng Fan, Chen Gao, Qingtao Wang, Yanmeng Yuan, Yan-nan Zhang, J. Han, Zhihui Hao","doi":"10.1080/09540105.2022.2060192","DOIUrl":"https://doi.org/10.1080/09540105.2022.2060192","url":null,"abstract":"ABSTRACT We investigated the effects of carbon tetrachloride (CCl4) exposure on liver detoxification. We confirmed that 0.2%-0.8% CCl4 decreased the liver carboxylesterase (CarE), lactate dehydrogenase (LDH) activity and total protein (TP) levels, while 0.2% and 0.8% CCl4 increased the liver acetylcholine esterase (AChE) activity (P< 0.05). It was observed0.4%-0.8% CCl4 increased serum glutathione S-transferase (GST) and catalase (CAT) activity, 0.1%-0.8% CCl4 increased the level of malondialdehyde (MDA), and 0.2% CCl4 increased the level of total superoxide dismutase (T-SOD). The expression of nod-like receptor protein 3 (NLRP3), interleukin-1β (IL-1β), and tumour necrosis factor-α (TNF-α) were significantly elevated in 0.2%-0.8% CCl4 exposure (P< 0.05). The expression of p38MAPK, gasdermin D (GSDMD), and nuclear factor kappa-B kinase (IKK) was decreased in 0.1%-0.8% CCl4 exposure, while the apoptosis was not statistically different in all groups. This indicates that 0.1% CCl4 exposure could damage the liver structure and detoxification function via p38MAPK/NF-κB/NLRP3 pathway. GRAPHICAL ABSTRACT","PeriodicalId":12300,"journal":{"name":"Food and Agricultural Immunology","volume":"33 1","pages":"235 - 251"},"PeriodicalIF":3.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46705773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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