Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1416641
W A Saka, O S Oyekunle, T M Akhigbe, O O Oladipo, M B Ajayi, A T Adekola, A I Omole, R E Akhigbe
Context: Although the hypoglycaemic effect of Andrographis paniculata (Burm.f.) Nees [Acanthaceae] has been documented, reports on its effect in an apparently healthy state are limited.
Objective: This study investigated whether or not A. paniculata exerts hypoglycaemic effect in a non-diabetic state. It also explored the impact of A. paniculata on glycolytic enzymes and GLUT 4 protein expression, as a possible mode of action.
Methods: Twenty male Wistar rats were randomly assigned into two groups (n = 10 rats/group). The control rats were vehicle-treated (0.5 ml of distilled water), while the A. paniculata-treated rats had 500 mg/kg of A. paniculata per os once daily for 35 days.
Results: A. paniculata treatment led to improved insulin sensitivity evidenced by increased HOMA-β (88.08 ± 2.13 vs. 120.80 ± 1.52, p < 0.0001), HOMA-S (283.60 ± 8.82 vs. 300.50 ± 9.30, p = 0.0189), and reduced TyG index (4.22 ± 0.04 vs. 3.95 ± 0.07, p < 0.0002) and HOMA-IR (0.32 ± 0.01 vs. 0.25 ± 0.01, p < 0.0001) when compared with the control. It also improved glucose regulation as depicted by reduced fasting blood glucose (3.77 ± 0.10 vs. 3.24 ± 0.11, p < 0.0001) and glycated hemoglobin (HbA1c; 7.69 ± 1.15 vs. 5.95 ± 0.82, p = 0.0245), and atherogenic dyslipidaemia, including AIP (-0.12 ± 0.03 vs. -0.26 ± 0.03, p < 0.0001) and CRI-I (2.70 ± 0.29 vs. 1.84 ± 0.27, p < 0.0001). These findings were accompanied by enhanced hepatic and muscular redox state, increased activities of glycolytic enzymes, upregulated GLUT 4 (0.80 ± 0.27 vs. 6.20 ± 0.84, p < 0.0001), and increased circulating nitric oxide (5.45 ± 0.24 vs. 6.79 ± 0.33, p = 0.0002).
Conclusion: A. paniculata exerts positive effect on glucose metabolism and utilization by improving insulin sensitivity and upregulating the activities of glycolytic enzymes and GLUT 4 protein expression. This implies that A. paniculata may be beneficial in preventing insulin resistance and incident diabetes. Nonetheless, it should be used with caution to prevent hypoglycaemia in a non-diabetic state.
背景:虽然穿心莲(Andrographis paniculata (Burm.f.) Nees [Acanthaceae])有降血糖作用的记载,但有关其在明显健康状态下降血糖作用的报道却很有限:本研究调查了穿心莲在非糖尿病状态下是否具有降血糖作用。本研究还探讨了 A. paniculata 对糖酵解酶和 GLUT 4 蛋白表达的影响,以此作为一种可能的作用模式:将 20 只雄性 Wistar 大鼠随机分为两组(n = 10 只/组)。对照组大鼠接受药物治疗(0.5 毫升蒸馏水),而西洋鹅掌楸治疗组大鼠每只口服 500 毫克/千克西洋鹅掌楸,每天一次,连续 35 天:结果:茨菰治疗可改善胰岛素敏感性,表现为 HOMA-β 增加(88.08 ± 2.13 vs. 120.80 ± 1.52,p p = 0.0189)、TyG 指数降低(4.22 ± 0.04 vs. 3.95 ± 0.07,p p p = 0.0245)和致动脉粥样硬化性血脂异常,包括 AIP(-0.12 ± 0.03 vs. -0.26 ± 0.03,p p p = 0.0002):结论:白花蛇舌草通过改善胰岛素敏感性、上调糖酵解酶活性和 GLUT 4 蛋白表达,对葡萄糖代谢和利用产生积极影响。这意味着A. paniculata对预防胰岛素抵抗和糖尿病可能有益。不过,在非糖尿病状态下,应谨慎使用它来预防低血糖症。
{"title":"<i>Andrographis paniculata</i> improves glucose regulation by enhancing insulin sensitivity and upregulating GLUT 4 expression in Wistar rats.","authors":"W A Saka, O S Oyekunle, T M Akhigbe, O O Oladipo, M B Ajayi, A T Adekola, A I Omole, R E Akhigbe","doi":"10.3389/fnut.2024.1416641","DOIUrl":"10.3389/fnut.2024.1416641","url":null,"abstract":"<p><strong>Context: </strong>Although the hypoglycaemic effect of <i>Andrographis paniculata (Burm.f.) Nees [Acanthaceae]</i> has been documented, reports on its effect in an apparently healthy state are limited.</p><p><strong>Objective: </strong>This study investigated whether or not <i>A. paniculata</i> exerts hypoglycaemic effect in a non-diabetic state. It also explored the impact of <i>A. paniculata</i> on glycolytic enzymes and GLUT 4 protein expression, as a possible mode of action.</p><p><strong>Methods: </strong>Twenty male Wistar rats were randomly assigned into two groups (<i>n</i> = 10 rats/group). The control rats were vehicle-treated (0.5 ml of distilled water), while the <i>A. paniculata</i>-treated rats had 500 mg/kg of <i>A. paniculata per os</i> once daily for 35 days.</p><p><strong>Results: </strong><i>A. paniculata</i> treatment led to improved insulin sensitivity evidenced by increased HOMA-β (88.08 ± 2.13 vs. 120.80 ± 1.52, <i>p</i> < 0.0001), HOMA-S (283.60 ± 8.82 vs. 300.50 ± 9.30, <i>p</i> = 0.0189), and reduced TyG index (4.22 ± 0.04 vs. 3.95 ± 0.07, <i>p</i> < 0.0002) and HOMA-IR (0.32 ± 0.01 vs. 0.25 ± 0.01, <i>p</i> < 0.0001) when compared with the control. It also improved glucose regulation as depicted by reduced fasting blood glucose (3.77 ± 0.10 vs. 3.24 ± 0.11, <i>p</i> < 0.0001) and glycated hemoglobin (HbA1c; 7.69 ± 1.15 vs. 5.95 ± 0.82, <i>p</i> = 0.0245), and atherogenic dyslipidaemia, including AIP (-0.12 ± 0.03 vs. -0.26 ± 0.03, <i>p</i> < 0.0001) and CRI-I (2.70 ± 0.29 vs. 1.84 ± 0.27, <i>p</i> < 0.0001). These findings were accompanied by enhanced hepatic and muscular redox state, increased activities of glycolytic enzymes, upregulated GLUT 4 (0.80 ± 0.27 vs. 6.20 ± 0.84, <i>p</i> < 0.0001), and increased circulating nitric oxide (5.45 ± 0.24 vs. 6.79 ± 0.33, <i>p</i> = 0.0002).</p><p><strong>Conclusion: </strong><i>A. paniculata</i> exerts positive effect on glucose metabolism and utilization by improving insulin sensitivity and upregulating the activities of glycolytic enzymes and GLUT 4 protein expression. This implies that <i>A. paniculata</i> may be beneficial in preventing insulin resistance and incident diabetes. Nonetheless, it should be used with caution to prevent hypoglycaemia in a non-diabetic state.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1416641"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1434150
Satoko Maruyama, Tsubasa Matsuoka, Koji Hosomi, Jonguk Park, Haruka Murakami, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Tadao Ooka, Zentaro Yamagata, Jun Kunisawa
Objective: Barley, abundant in β-glucan, a soluble dietary fiber, holds promise in obesity prevention. Given the microbial metabolism of dietary fiber in the gastrointestinal tract, we investigated the role of gut microbiota in non-obese individuals consuming high levels of barley.
Methods: Our study enrolled 185 participants from "The cohort study on barley and the intestinal environment (UMIN000033479)." Comprehensive physical examinations, including blood tests, were conducted, along with separate assessments of gut microbiome profiling and dietary intake. Participants were categorized into high and low barley consumption groups based on the median intake, with non-obese individuals in the high intake group identified as barley responders while participants with obesity were designated as non-responders. We compared the relative abundance of intestinal bacteria between these groups and used multivariate analysis to assess the association between intestinal bacteria and barley responders while controlling for confounding factors.
Results and discussion: Among the fermented food choices, responders exhibited notably higher consumption of natto (fermented soybeans) than non-responders. Moreover, after adjusting for confounders, Butyricicoccus and Subdoligranulum were found to be significantly more prevalent in the intestines of responders. Given natto's inclusion of Bacillus subtilis, a glycolytic bacterium, and the butyrate-producing capabilities of Butyricicoccus and Subdoligranulum, it is hypothesized that fiber degradation and butyrate production are likely to be enhanced within the digestive tract of barley responders.
{"title":"High barley intake in non-obese individuals is associated with high natto consumption and abundance of butyrate-producing bacteria in the gut: a cross-sectional study.","authors":"Satoko Maruyama, Tsubasa Matsuoka, Koji Hosomi, Jonguk Park, Haruka Murakami, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Tadao Ooka, Zentaro Yamagata, Jun Kunisawa","doi":"10.3389/fnut.2024.1434150","DOIUrl":"10.3389/fnut.2024.1434150","url":null,"abstract":"<p><strong>Objective: </strong>Barley, abundant in <i>β</i>-glucan, a soluble dietary fiber, holds promise in obesity prevention. Given the microbial metabolism of dietary fiber in the gastrointestinal tract, we investigated the role of gut microbiota in non-obese individuals consuming high levels of barley.</p><p><strong>Methods: </strong>Our study enrolled 185 participants from \"The cohort study on barley and the intestinal environment (UMIN000033479).\" Comprehensive physical examinations, including blood tests, were conducted, along with separate assessments of gut microbiome profiling and dietary intake. Participants were categorized into high and low barley consumption groups based on the median intake, with non-obese individuals in the high intake group identified as barley responders while participants with obesity were designated as non-responders. We compared the relative abundance of intestinal bacteria between these groups and used multivariate analysis to assess the association between intestinal bacteria and barley responders while controlling for confounding factors.</p><p><strong>Results and discussion: </strong>Among the fermented food choices, responders exhibited notably higher consumption of natto (fermented soybeans) than non-responders. Moreover, after adjusting for confounders, <i>Butyricicoccus</i> and <i>Subdoligranulum</i> were found to be significantly more prevalent in the intestines of responders. Given natto's inclusion of <i>Bacillus subtilis</i>, a glycolytic bacterium, and the butyrate-producing capabilities of <i>Butyricicoccus</i> and <i>Subdoligranulum</i>, it is hypothesized that fiber degradation and butyrate production are likely to be enhanced within the digestive tract of barley responders.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1434150"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1477537
Dong Liu, Zi-Xiang Xu, Xue-Lian Liu, Hai-Ling Yang, Ling-Ling Wang, Yan Li
Aims: The metabolic syndrome (MetS), a collection of conditions that heighten the risk of disease development and impose economic burdens on patients. However, the causal relationship between education and MetS was uncertain. In this study, the Mendelian randomization (MR) method was employed to elucidate the potential causal link between education and the MetS and its components.
Method: Single nucleotide polymorphisms (SNPs) associated with education, MetS, and its components were sourced from a public database, with the inverse variance-weighted (IVW) method utilized for analysis.
Results: Education demonstrated a significant negative correlation with the risk of MetS (OR = 0.55, 95% CI = 0.48-0.63, p = 2.18E-51), waist circumference(OR = 0.80, 95% CI = 0.76-0.83, p = 4.98E-33), hypertension (OR = 0.96, 95% CI = 0.95-0.97; p = 4.54E-10), Fasting blood glucose (OR = 0.94, 95% CI = 0.91-0.97, p = 7.58E-6) and triglycerides (OR = 0.83, 95% CI = 0.79-0.87, p = 7.87E-18) while showing a positive association with high-density lipoprotein cholesterol (OR = 1.22, 95% CI = 1.18-1.25, p = 1.45E-31).
Conclusion: The findings of this study suggest that education can decrease the incidence of MetS.
目的:代谢综合征(MetS)是一系列疾病的集合,会增加疾病发生的风险,并给患者带来经济负担。然而,教育与代谢综合征之间的因果关系尚不确定。本研究采用孟德尔随机化(MR)方法来阐明教育与 MetS 及其组成部分之间的潜在因果关系:方法:从公共数据库中获取与教育、MetS 及其组成部分相关的单核苷酸多态性(SNPs),并采用逆方差加权法(IVW)进行分析:结果显示:教育程度与 MetS(OR = 0.55,95% CI = 0.48-0.63,p = 2.18E-51)、腰围(OR = 0.80,95% CI = 0.76-0.83,p = 4.98E-33)、高血压(OR = 0.96,95% CI = 0.95-0.97;p = 4.54E-10)、空腹血糖(OR = 0.94,95% CI = 0.91-0.97,p = 7.58E-6)和甘油三酯(OR = 0.83,95% CI = 0.79-0.87,p = 7.87E-18),而与高密度脂蛋白胆固醇(OR = 1.22,95% CI = 1.18-1.25,p = 1.45E-31)呈正相关:本研究结果表明,教育可以降低 MetS 的发病率。
{"title":"Education and metabolic syndrome: a Mendelian randomization study.","authors":"Dong Liu, Zi-Xiang Xu, Xue-Lian Liu, Hai-Ling Yang, Ling-Ling Wang, Yan Li","doi":"10.3389/fnut.2024.1477537","DOIUrl":"10.3389/fnut.2024.1477537","url":null,"abstract":"<p><strong>Aims: </strong>The metabolic syndrome (MetS), a collection of conditions that heighten the risk of disease development and impose economic burdens on patients. However, the causal relationship between education and MetS was uncertain. In this study, the Mendelian randomization (MR) method was employed to elucidate the potential causal link between education and the MetS and its components.</p><p><strong>Method: </strong>Single nucleotide polymorphisms (SNPs) associated with education, MetS, and its components were sourced from a public database, with the inverse variance-weighted (IVW) method utilized for analysis.</p><p><strong>Results: </strong>Education demonstrated a significant negative correlation with the risk of MetS (OR = 0.55, 95% CI = 0.48-0.63, <i>p</i> = 2.18E-51), waist circumference(OR = 0.80, 95% CI = 0.76-0.83, <i>p</i> = 4.98E-33), hypertension (OR = 0.96, 95% CI = 0.95-0.97; <i>p</i> = 4.54E-10), Fasting blood glucose (OR = 0.94, 95% CI = 0.91-0.97, <i>p</i> = 7.58E-6) and triglycerides (OR = 0.83, 95% CI = 0.79-0.87, <i>p</i> = 7.87E-18) while showing a positive association with high-density lipoprotein cholesterol (OR = 1.22, 95% CI = 1.18-1.25, <i>p</i> = 1.45E-31).</p><p><strong>Conclusion: </strong>The findings of this study suggest that education can decrease the incidence of MetS.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1477537"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1437521
Xun Xu, Yuwei Huang, Yue Zhu, Qingwen Jin
Background: Recently, a growing number of studies have specifically examined the impact of dietary variables on the development and progression of amyotrophic lateral sclerosis (ALS). The purpose of this study was to investigate the correlation between different dietary patterns and Chinese ALS patients' prognosis.
Methods: A retrospective study was conducted by recruiting 590 patients with ALS who attended and were regularly followed at hospitals in Nanjing from 2016 to 2023. Nutrient intake was calculated using dietary information collected through the food frequency questionnaire (FFQ), and patients were divided into a control group and special diet groups, including a high-calorie group (HC), a high-protein group (HP), and a ketogenic diet group (KD), based on their specific intake. And used the Kaplan-Meier product limiting distribution to compare the time required to transition between phases of different dietary patterns and to estimate cumulative survival probabilities.
Results: Patients in the HP had a better nutritional status. And the disease progression rate (ΔFS) was significantly associated with dietary patterns, with the KD group having the lowest ΔFS. Meanwhile, special diets extended the survival time of stage 4 patients but had no effect on the overall survival of the disease.
Conclusion: A special diet can be one of effective options for patients with advanced ALS. Patients with poor nutritional status may choose the HP diet, whereas those with underlying conditions should consider the ketogenic diet with caution.
背景:最近,越来越多的研究专门探讨了膳食变量对肌萎缩性脊髓侧索硬化症(ALS)发生和发展的影响。本研究旨在探讨不同饮食模式与中国 ALS 患者预后之间的相关性:这项回顾性研究招募了590名ALS患者,他们于2016年至2023年期间在南京的医院就诊并接受定期随访。通过食物频率问卷(FFQ)收集的膳食信息计算营养素摄入量,并根据具体摄入量将患者分为对照组和特殊饮食组,包括高热量组(HC)、高蛋白组(HP)和生酮饮食组(KD)。并使用 Kaplan-Meier 乘积限制分布来比较不同饮食模式的阶段转换所需的时间,并估算累积生存概率:结果:HP患者的营养状况更好。结果显示:HP 组患者的营养状况更好,疾病进展率(ΔFS)与饮食模式有显著相关性,其中 KD 组的ΔFS 最低。同时,特殊饮食延长了第四期患者的生存时间,但对疾病的总体生存率没有影响:结论:特殊饮食是 ALS 晚期患者的有效选择之一。结论:特殊饮食是 ALS 晚期患者的有效选择之一,营养状况较差的患者可选择 HP 饮食,而有基础疾病的患者应慎重考虑生酮饮食。
{"title":"Association between dietary patterns and the prognosis of amyotrophic lateral sclerosis in China: a cross-sectional study.","authors":"Xun Xu, Yuwei Huang, Yue Zhu, Qingwen Jin","doi":"10.3389/fnut.2024.1437521","DOIUrl":"10.3389/fnut.2024.1437521","url":null,"abstract":"<p><strong>Background: </strong>Recently, a growing number of studies have specifically examined the impact of dietary variables on the development and progression of amyotrophic lateral sclerosis (ALS). The purpose of this study was to investigate the correlation between different dietary patterns and Chinese ALS patients' prognosis.</p><p><strong>Methods: </strong>A retrospective study was conducted by recruiting 590 patients with ALS who attended and were regularly followed at hospitals in Nanjing from 2016 to 2023. Nutrient intake was calculated using dietary information collected through the food frequency questionnaire (FFQ), and patients were divided into a control group and special diet groups, including a high-calorie group (HC), a high-protein group (HP), and a ketogenic diet group (KD), based on their specific intake. And used the Kaplan-Meier product limiting distribution to compare the time required to transition between phases of different dietary patterns and to estimate cumulative survival probabilities.</p><p><strong>Results: </strong>Patients in the HP had a better nutritional status. And the disease progression rate (ΔFS) was significantly associated with dietary patterns, with the KD group having the lowest ΔFS. Meanwhile, special diets extended the survival time of stage 4 patients but had no effect on the overall survival of the disease.</p><p><strong>Conclusion: </strong>A special diet can be one of effective options for patients with advanced ALS. Patients with poor nutritional status may choose the HP diet, whereas those with underlying conditions should consider the ketogenic diet with caution.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1437521"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142618015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1453240
Chong-Hui Wang, Meng-Han Jiang, Ji-Min Ma, Ming-Cong Yuan, Lei Liao, Hao-Zhang Duan, Dan Wang, Lian Duan
Background: Hypoalbuminemia is a common complication in patients with chronic kidney disease (CKD) and is associated with various adverse clinical events. Currently, there are few studies focused on identifying risk factors and constructing models for hypoalbuminemia in patients with CKD stages 3 and 4. This study aims to identify independent risk factors for hypoalbuminemia in patients with CKD stages 3 and 4 and construct a nomogram for predicting the risk of hypoalbuminemia in these patients.
Methods: A total of 237 patients with CKD stages 3 and 4 treated at Anning First People's Hospital from January to December 2023 were included. Univariate and bidirectional stepwise multivariate logistic regression analyses were used to identify independent risk factors for hypoalbuminemia in these patients. Based on the results of logistic regression analyses, a nomogram was constructed. The model performance was assessed using area under the receiver operator characteristic curve, calibration curves, and decision curve analysis.
Results: Hemoglobin, red blood cells, serum sodium, and serum calcium were identified as independent risk factors for hypoalbuminemia in these patients. The contributions of each independent risk factor to hypoalbuminemia were visualized in a nomogram. The area under the receiver operator characteristic curve of the model was 0.819, indicating good discrimination. The calibration curves showed good agreement between predicted and observed outcomes. The decision curve analysis also verified that the model had the good clinical utility.
Conclusion: Hemoglobin, red blood cells, serum sodium, and serum calcium were identified as independent risk factors of hypoalbuminemia in patients with CKD stages 3 and 4. The nomogram exhibits good discrimination, calibration, and clinical utility, offering a reliable tool for the early prediction and identification of hypoalbuminemia in these patients.
{"title":"Identification of independent risk factors for hypoalbuminemia in patients with CKD stages 3 and 4: the construction of a nomogram.","authors":"Chong-Hui Wang, Meng-Han Jiang, Ji-Min Ma, Ming-Cong Yuan, Lei Liao, Hao-Zhang Duan, Dan Wang, Lian Duan","doi":"10.3389/fnut.2024.1453240","DOIUrl":"10.3389/fnut.2024.1453240","url":null,"abstract":"<p><strong>Background: </strong>Hypoalbuminemia is a common complication in patients with chronic kidney disease (CKD) and is associated with various adverse clinical events. Currently, there are few studies focused on identifying risk factors and constructing models for hypoalbuminemia in patients with CKD stages 3 and 4. This study aims to identify independent risk factors for hypoalbuminemia in patients with CKD stages 3 and 4 and construct a nomogram for predicting the risk of hypoalbuminemia in these patients.</p><p><strong>Methods: </strong>A total of 237 patients with CKD stages 3 and 4 treated at Anning First People's Hospital from January to December 2023 were included. Univariate and bidirectional stepwise multivariate logistic regression analyses were used to identify independent risk factors for hypoalbuminemia in these patients. Based on the results of logistic regression analyses, a nomogram was constructed. The model performance was assessed using area under the receiver operator characteristic curve, calibration curves, and decision curve analysis.</p><p><strong>Results: </strong>Hemoglobin, red blood cells, serum sodium, and serum calcium were identified as independent risk factors for hypoalbuminemia in these patients. The contributions of each independent risk factor to hypoalbuminemia were visualized in a nomogram. The area under the receiver operator characteristic curve of the model was 0.819, indicating good discrimination. The calibration curves showed good agreement between predicted and observed outcomes. The decision curve analysis also verified that the model had the good clinical utility.</p><p><strong>Conclusion: </strong>Hemoglobin, red blood cells, serum sodium, and serum calcium were identified as independent risk factors of hypoalbuminemia in patients with CKD stages 3 and 4. The nomogram exhibits good discrimination, calibration, and clinical utility, offering a reliable tool for the early prediction and identification of hypoalbuminemia in these patients.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1453240"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1445125
Sarah Alrehaili, Abeer A Afifi, Reham M Algheshairy, Taqwa Bushnaq, Talal Ali F Alharbi, Hend F Alharbi
Objectives: A prevalent symptom of many mental health issues, such as depression, is anhedonia, which is the inability to feel joy or pleasure. Tension-induced sensations, anxious thoughts, and bodily alterations are the hallmarks of anxiety. One known environmental factor that affects mental health is diet. In this implication, eating appetizing meals has been proposed to reduce unpleasant feelings like worry. This study aimed to indicate whether eating habits among postgraduate students are related to symptoms of anhedonia and/or anxiety.
Methods: In a cross-sectional study, responses were collected from a total of 393 postgraduate students. Each student self-answered the General Anxiety Disorder-7, Snaith-Hamilton Pleasure Scale for Anhedonia, and the Food Consumption Questionnaire and reported the body weight.
Results: The prevalence of anhedonia was 28%, moderate anxiety and severe anxiety were 15.7 and 10.9%, respectively. In this research, results showed that sugary foods, fast food, and fried foods were positively associated with anxiety and anhedonia. However, fruits and vegetables were negatively associated with anxiety and anhedonia. Linear regression showed that fruit and drinking water consumption was significant with the number of meals/day. There was no significance between the number of meals per day and anhedonia; however, there was statistical significance with the total GAD-7 scale score regarding the number of meals/per day.
Conclusion: Anhedonia and anxiety are associated with food consumption, especially foods rich in sugars, fast and fried, which help to increase positive feelings. Future studies should focus on understanding the relationship between food consumption and following a healthy diet and improving and reducing symptoms of anxiety and anhedonia in those who suffer from a stressful or task-filled lifestyle, such as students, especially postgraduate students. In addition, it focuses on the importance of awareness of the symptoms of anhedonia, which is classified as a depressive disease, and how to control anxiety to maintain better mental health.
{"title":"Prevalence of anhedonia, anxiety, and their impact on food consumption among postgraduate Qassim University students.","authors":"Sarah Alrehaili, Abeer A Afifi, Reham M Algheshairy, Taqwa Bushnaq, Talal Ali F Alharbi, Hend F Alharbi","doi":"10.3389/fnut.2024.1445125","DOIUrl":"10.3389/fnut.2024.1445125","url":null,"abstract":"<p><strong>Objectives: </strong>A prevalent symptom of many mental health issues, such as depression, is anhedonia, which is the inability to feel joy or pleasure. Tension-induced sensations, anxious thoughts, and bodily alterations are the hallmarks of anxiety. One known environmental factor that affects mental health is diet. In this implication, eating appetizing meals has been proposed to reduce unpleasant feelings like worry. This study aimed to indicate whether eating habits among postgraduate students are related to symptoms of anhedonia and/or anxiety.</p><p><strong>Methods: </strong>In a cross-sectional study, responses were collected from a total of 393 postgraduate students. Each student self-answered the General Anxiety Disorder-7, Snaith-Hamilton Pleasure Scale for Anhedonia, and the Food Consumption Questionnaire and reported the body weight.</p><p><strong>Results: </strong>The prevalence of anhedonia was 28%, moderate anxiety and severe anxiety were 15.7 and 10.9%, respectively. In this research, results showed that sugary foods, fast food, and fried foods were positively associated with anxiety and anhedonia. However, fruits and vegetables were negatively associated with anxiety and anhedonia. Linear regression showed that fruit and drinking water consumption was significant with the number of meals/day. There was no significance between the number of meals per day and anhedonia; however, there was statistical significance with the total GAD-7 scale score regarding the number of meals/per day.</p><p><strong>Conclusion: </strong>Anhedonia and anxiety are associated with food consumption, especially foods rich in sugars, fast and fried, which help to increase positive feelings. Future studies should focus on understanding the relationship between food consumption and following a healthy diet and improving and reducing symptoms of anxiety and anhedonia in those who suffer from a stressful or task-filled lifestyle, such as students, especially postgraduate students. In addition, it focuses on the importance of awareness of the symptoms of anhedonia, which is classified as a depressive disease, and how to control anxiety to maintain better mental health.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1445125"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1482125
Han Zhang, Haidong Wang, Hongyan Zhou, Jialin Shi, Zhiqiang Wan, Guangzhe Li, Mingming Yan
Introduction: Ginseng and Schisandra are traditional Chinese plants that have been used in culinary practices and are renowned for their immune-boosting properties. In Chinese medicine, Ginseng and Schisandra are frequently used together as a clinical pair to mutually enhance their effect, producing a synergistic effect when consumed in combination. However, the underlying mechanism of their synergistic effect remains uncertain. Therefore, this study investigates the synergistic effect of Ginseng-Schisandra in terms of macromolecular proteins.
Methods: We used a dual-protein research methodology combined with co-extraction techniques to obtain the co-extracted protein of ginseng and Schisandra. We then compared the physicochemical and functional properties and antioxidant activities of co-extracted protein (COP), simple mixed protein (SMP), Ginseng protein (PGP), and Schisandra protein (SCP).
Results: Generally, PGP and SCP are considered as functional food with antioxidant activity. COP are composite proteins with a shared internal structure that are combined by Ginseng and Schisandra proteins, while SMP are simple mixtures of PGP and SCP. Free radical scavenging experiments indicated that COP exhibited the highest scavenging ability for hydroxyl radicals (98.89%), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (85.95%), and 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS+) radicals (42.69%). In vitro, COP significantly reduced the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA), while increasing intracellular levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and lactate dehydrogenase (LDH) levels in HepG2 cells.
Discussion: The comparative results of the macromolecular proteins reveal that COP contributes to the synergistic effect of Ginseng-Schisandra and indicate the advantages of co-extraction in protein production, suggesting the potential application of COP in the food industry.
{"title":"Synergistic effect in the co-extraction of <i>Ginseng</i> and <i>Schisandra</i> protein.","authors":"Han Zhang, Haidong Wang, Hongyan Zhou, Jialin Shi, Zhiqiang Wan, Guangzhe Li, Mingming Yan","doi":"10.3389/fnut.2024.1482125","DOIUrl":"10.3389/fnut.2024.1482125","url":null,"abstract":"<p><strong>Introduction: </strong><i>Ginseng</i> and <i>Schisandra</i> are traditional Chinese plants that have been used in culinary practices and are renowned for their immune-boosting properties. In Chinese medicine, <i>Ginseng</i> and <i>Schisandra</i> are frequently used together as a clinical pair to mutually enhance their effect, producing a synergistic effect when consumed in combination. However, the underlying mechanism of their synergistic effect remains uncertain. Therefore, this study investigates the synergistic effect of <i>Ginseng</i>-<i>Schisandra</i> in terms of macromolecular proteins.</p><p><strong>Methods: </strong>We used a dual-protein research methodology combined with co-extraction techniques to obtain the co-extracted protein of ginseng and Schisandra. We then compared the physicochemical and functional properties and antioxidant activities of co-extracted protein (COP), simple mixed protein (SMP), <i>Ginseng</i> protein (PGP), and <i>Schisandra</i> protein (SCP).</p><p><strong>Results: </strong>Generally, PGP and SCP are considered as functional food with antioxidant activity. COP are composite proteins with a shared internal structure that are combined by <i>Ginseng</i> and <i>Schisandra</i> proteins, while SMP are simple mixtures of PGP and SCP. Free radical scavenging experiments indicated that COP exhibited the highest scavenging ability for hydroxyl radicals (98.89%), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals (85.95%), and 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS+) radicals (42.69%). <i>In vitro</i>, COP significantly reduced the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA), while increasing intracellular levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and lactate dehydrogenase (LDH) levels in HepG2 cells.</p><p><strong>Discussion: </strong>The comparative results of the macromolecular proteins reveal that COP contributes to the synergistic effect of Ginseng-Schisandra and indicate the advantages of co-extraction in protein production, suggesting the potential application of COP in the food industry.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1482125"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1416554
Natália Caldeira de Carvalho, Clarisse Lolli E Silva, Juliana Costa Liboredo
The objective of this study was to investigate the perceptions and attitudes of consumers toward food service safety and hygiene when purchasing ready-to-eat food. Data were collected at three time points: before (T0) and during the COVID-19 pandemic (T1 and T2). Among the 333 participants, 45.9% reported fear of contracting COVID-19 when purchasing off-site meals, and 78.4% for on-site meals in T1, compared to 21.0 and 52.0% in T2, respectively (p < 0.001). Hygiene and cleanliness of the establishment became less important for participants when selecting food services throughout the pandemic (T0: 42.6%; T1: 41.1%; T2: 0.0%; p < 0.01). Security protocols during off-site and on-site purchases were considered important by more participants in T1 (47.7 and 27.6%, respectively) than in T0 (28.8 and 9.0%, respectively), with a decrease in T2 (0 and 16.5%, respectively; p < 0.01). Regarding food delivery services, concerns about hygiene decreased in T1 (44%) compared to T0 (63.7%) but increased again in T2 (76%; p < 0.01). Precautions with the food packaging was less prevalent at least during one point in the pandemic compared to T0 (p < 0.01), while heating food before consumption was more common at the onset of the pandemic (T1) but declined by T2 (p < 0.01). Furthermore, the use of cash decreased while contactless payment methods increased during the pandemic. In conclusion, different phases of the COVID-19 pandemic significantly influenced consumer behavior and attitudes toward purchasing ready-to-eat food.
本研究旨在调查消费者在购买即食食品时对餐饮安全和卫生的看法和态度。数据在三个时间点收集:COVID-19 流行前(T0)和流行期间(T1 和 T2)。在 333 名参与者中,45.9% 的人表示在购买场外餐饮时担心感染 COVID-19,78.4% 的人表示在购买场内餐饮时担心感染 COVID-19,而在 T1 和 T2 中,这一比例分别为 21.0% 和 52.0% (P P P P P
{"title":"Food service safety and hygiene factors: a longitudinal study on the Brazilian consumer perception.","authors":"Natália Caldeira de Carvalho, Clarisse Lolli E Silva, Juliana Costa Liboredo","doi":"10.3389/fnut.2024.1416554","DOIUrl":"10.3389/fnut.2024.1416554","url":null,"abstract":"<p><p>The objective of this study was to investigate the perceptions and attitudes of consumers toward food service safety and hygiene when purchasing ready-to-eat food. Data were collected at three time points: before (T0) and during the COVID-19 pandemic (T1 and T2). Among the 333 participants, 45.9% reported fear of contracting COVID-19 when purchasing off-site meals, and 78.4% for on-site meals in T1, compared to 21.0 and 52.0% in T2, respectively (<i>p</i> < 0.001). Hygiene and cleanliness of the establishment became less important for participants when selecting food services throughout the pandemic (T0: 42.6%; T1: 41.1%; T2: 0.0%; <i>p</i> < 0.01). Security protocols during off-site and on-site purchases were considered important by more participants in T1 (47.7 and 27.6%, respectively) than in T0 (28.8 and 9.0%, respectively), with a decrease in T2 (0 and 16.5%, respectively; <i>p</i> < 0.01). Regarding food delivery services, concerns about hygiene decreased in T1 (44%) compared to T0 (63.7%) but increased again in T2 (76%; <i>p</i> < 0.01). Precautions with the food packaging was less prevalent at least during one point in the pandemic compared to T0 (<i>p</i> < 0.01), while heating food before consumption was more common at the onset of the pandemic (T1) but declined by T2 (<i>p</i> < 0.01). Furthermore, the use of cash decreased while contactless payment methods increased during the pandemic. In conclusion, different phases of the COVID-19 pandemic significantly influenced consumer behavior and attitudes toward purchasing ready-to-eat food.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1416554"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1428445
Xueying Li, Congcong Zhang, Yihui Weng, Weiming Yu, Xianlei Cai
Background: The effect of tea consumption on conditions such as hypertension, diabetes, and obesity has attracted significant global interest. However, the results of various studies on this topic have been mixed and somewhat contentious. Therefore, we conducted a Mendelian randomization (MR) analysis to investigate the causal relationships between tea consumption and the aforementioned health conditions.
Methods: A bidirectional two-sample MR analysis was used to systematically explores the associations between tea consumption and hypertension, diabetes, and obesity. MR-Egger regression, weighted median, inverse variance weighted, and weighted mode methods were used to evaluate the potential causal associations. Leave-one-out sensitivity test was used to check the robustness of the IVW estimates.
Results: MR analysis indicated that genetically predicted tea consumption is associated with a protective effect against hypertension, with an odds ratio (OR) of 0.78 and a 95% confidence interval (CI) ranging from 0.64 to 0.95. Additionally, tea consumption appeared to have a potential protective effect on type 2 diabetes and obesity related to excessive calorie intake, influenced by specific single nucleotide polymorphisms (SNPs), namely "rs57462170" and "rs17685." No causal link was observed between the consumption of green or herbal tea and hypertension, diabetes, or obesity. However, there was a marginal negative association between type 2 diabetes and tea consumption and (OR = 0.99; 95% CI: 0.97-1.00) and a significant negative correlation between obesity due to excessive calorie intake and green tea consumption (OR = 0.35; 95% CI: 0.16-0.78).
Conclusion: This study demonstrates a protective causal relationship between the consumption of tea (including black and green teas) and reduced risk of hypertension. Furthermore, our results suggest that tea intake may also have a protective effect on type 2 diabetes and obesity. The results recommend further research to verify or refine these findings.
{"title":"Effect of tea consumption on the development of hypertension, diabetes, and obesity: a bidirectional two-sample Mendelian randomization analysis.","authors":"Xueying Li, Congcong Zhang, Yihui Weng, Weiming Yu, Xianlei Cai","doi":"10.3389/fnut.2024.1428445","DOIUrl":"10.3389/fnut.2024.1428445","url":null,"abstract":"<p><strong>Background: </strong>The effect of tea consumption on conditions such as hypertension, diabetes, and obesity has attracted significant global interest. However, the results of various studies on this topic have been mixed and somewhat contentious. Therefore, we conducted a Mendelian randomization (MR) analysis to investigate the causal relationships between tea consumption and the aforementioned health conditions.</p><p><strong>Methods: </strong>A bidirectional two-sample MR analysis was used to systematically explores the associations between tea consumption and hypertension, diabetes, and obesity. MR-Egger regression, weighted median, inverse variance weighted, and weighted mode methods were used to evaluate the potential causal associations. Leave-one-out sensitivity test was used to check the robustness of the IVW estimates.</p><p><strong>Results: </strong>MR analysis indicated that genetically predicted tea consumption is associated with a protective effect against hypertension, with an odds ratio (OR) of 0.78 and a 95% confidence interval (CI) ranging from 0.64 to 0.95. Additionally, tea consumption appeared to have a potential protective effect on type 2 diabetes and obesity related to excessive calorie intake, influenced by specific single nucleotide polymorphisms (SNPs), namely \"rs57462170\" and \"rs17685.\" No causal link was observed between the consumption of green or herbal tea and hypertension, diabetes, or obesity. However, there was a marginal negative association between type 2 diabetes and tea consumption and (OR = 0.99; 95% CI: 0.97-1.00) and a significant negative correlation between obesity due to excessive calorie intake and green tea consumption (OR = 0.35; 95% CI: 0.16-0.78).</p><p><strong>Conclusion: </strong>This study demonstrates a protective causal relationship between the consumption of tea (including black and green teas) and reduced risk of hypertension. Furthermore, our results suggest that tea intake may also have a protective effect on type 2 diabetes and obesity. The results recommend further research to verify or refine these findings.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1428445"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31eCollection Date: 2024-01-01DOI: 10.3389/fnut.2024.1454364
Lingling Lu, Xiaoli Gu, Daheng Yang, Bingjian Wang, Guangfeng Long
Background: Combining genetic risk factors and plasma fatty acids (FAs) can be used as an effective method of precision medicine to prevent hypertension risk.
Methods: A total of 195,250 participants in the UK Biobank cohort were included in this study from 2006-2010. Polygenic risk scores (PRSs) were calculated for hypertension using single-nucleotide polymorphisms (SNPs). Concentrations of plasma FAs, including polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs), were tested by nuclear magnetic resonance. The Cox model was used to test for the main effects of PRS, different plasma FAs and their joint effects on hypertension. Relative excess risk due to interaction (RERI) and the attributable proportion due to interaction (AP) were used to test the additive interaction.
Results: Plasma PUFAs, n-3 PUFAs, MUFAs and SFAs were related to the risk of hypertension (PUFAs: HR, 0.878; 95% CI, 0.868-0.888; MUFAs: HR, 1.13; 95% CI, 1.123-1.150; SFAs: HR, 1.086; 95% CI, 1.074-1.098; n-3 PUFAs: HR, 0.984; 95% CI, 0.973-0.995). Moreover, an additive interaction was found between PRS and plasma FAs, which could contribute to an approximately 10-18% risk of hypertension, and the associations between high plasma MUFAs and a high PRS of hypertension were the strongest positive [RERI: 0.178 (95% CI: 0.062, 0.294), AP: 0.079 (95% CI: 0.027, 0.130)].
Conclusion: Increased plasma MUFAs or SFAs and decreased plasma PUFAs or n-3 PUFAs were associated with hypertension risk, especially among people at high genetic risk.
{"title":"Circulating fatty acids, genetic susceptibility and hypertension: a prospective cohort study.","authors":"Lingling Lu, Xiaoli Gu, Daheng Yang, Bingjian Wang, Guangfeng Long","doi":"10.3389/fnut.2024.1454364","DOIUrl":"10.3389/fnut.2024.1454364","url":null,"abstract":"<p><strong>Background: </strong>Combining genetic risk factors and plasma fatty acids (FAs) can be used as an effective method of precision medicine to prevent hypertension risk.</p><p><strong>Methods: </strong>A total of 195,250 participants in the UK Biobank cohort were included in this study from 2006-2010. Polygenic risk scores (PRSs) were calculated for hypertension using single-nucleotide polymorphisms (SNPs). Concentrations of plasma FAs, including polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs), were tested by nuclear magnetic resonance. The Cox model was used to test for the main effects of PRS, different plasma FAs and their joint effects on hypertension. Relative excess risk due to interaction (RERI) and the attributable proportion due to interaction (AP) were used to test the additive interaction.</p><p><strong>Results: </strong>Plasma PUFAs, n-3 PUFAs, MUFAs and SFAs were related to the risk of hypertension (PUFAs: HR, 0.878; 95% CI, 0.868-0.888; MUFAs: HR, 1.13; 95% CI, 1.123-1.150; SFAs: HR, 1.086; 95% CI, 1.074-1.098; n-3 PUFAs: HR, 0.984; 95% CI, 0.973-0.995). Moreover, an additive interaction was found between PRS and plasma FAs, which could contribute to an approximately 10-18% risk of hypertension, and the associations between high plasma MUFAs and a high PRS of hypertension were the strongest positive [RERI: 0.178 (95% CI: 0.062, 0.294), AP: 0.079 (95% CI: 0.027, 0.130)].</p><p><strong>Conclusion: </strong>Increased plasma MUFAs or SFAs and decreased plasma PUFAs or n-3 PUFAs were associated with hypertension risk, especially among people at high genetic risk.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1454364"},"PeriodicalIF":4.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}