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Implication of nutrition in severity of symptoms and treatments in quality of life in Parkinson's disease: a systematic review. 营养对帕金森病症状严重程度和治疗对生活质量的影响:系统综述。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1434290
Naia Ayo Mentxakatorre, Beatriz Tijero, María Ángeles Acera, Tamara Fernández-Valle, Marta Ruiz-Lopez, Juan Carlos Gómez-Esteban, Rocio Del Pino

Parkinson's disease (PD) is characterized by motor and non-motor symptoms. Nutritional alterations are one of the non-motor symptoms that most influence the quality of life (QoL) in PD.

Objective: Therefore, this review aims to evaluate whether nutritional alterations are related either to the severity of motor and non-motor symptoms through the gut-brain axis or to the different treatments for PD and whether all of this, in turn, impacts the QoL of patients.

Methods: A systematic review was carried out in MEDLINE and EMBASE databases, and Mendeley from 2000 to June 2024, searching for articles related to nutritional alterations in PD that alter patients' QoL. A total of 14 articles (2,187 participants) of 924 records were included.

Results: Among the 14 studies examined, two investigated the relationship between nutritional status and QoL in patients with PD. Poor nutritional status was associated with lower QoL scores. Four studies explored the connection between nutritional status and its impact on both motor and non-motor symptoms (psychiatric disturbances, cognitive impairment, and fatigue), revealing a link between nutritional status, activities of daily living, and the severity of motor symptoms. Three studies identified changes in body weight associated with the severity of symptoms related to mobility issues in PD patients. Three studies investigated the relationship between different PD treatments and their interaction with changes in weight and energy metabolism, highlighting that weight loss in the early stages of PD needs adequate monitoring of different treatments, as well as the interaction between the central and peripheral nervous systems in regulating these processes. Finally, two studies investigated how gastrointestinal alterations and changes in the microbiota were related to cognitive status, thus identifying them as risk factors and early signs of PD.

Discussion: The systematic review highlighted the significant relationship between nutritional status and QoL in patients with PD, as well as how the PD treatments influenced their weight. An association was also observed in the gut-brain axis, where adequate nutritional status influenced the balance of intestinal microbiota, slowing cognitive decline, improving activities of daily living, and the QoL of PD patients. It is confirmed that the nutritional status of patients influenced both motor and non-motor symptoms of the disease, and therefore their QoL.

帕金森病(PD)以运动症状和非运动症状为特征。营养改变是影响帕金森病患者生活质量(QoL)最严重的非运动症状之一:因此,本综述旨在评估营养改变是否通过肠脑轴与运动和非运动症状的严重程度有关,或与帕金森病的不同治疗方法有关,以及所有这些是否会反过来影响患者的生活质量:从 2000 年到 2024 年 6 月,在 MEDLINE 和 EMBASE 数据库以及 Mendeley 中进行了系统性综述,搜索与改变患者 QoL 的帕金森病营养改变相关的文章。共收录了14篇文章(2187名参与者)的924条记录:在14项研究中,有两项研究调查了帕金森病患者营养状况与QoL之间的关系。营养状况差与 QoL 评分较低有关。四项研究探讨了营养状况与其对运动症状和非运动症状(精神障碍、认知障碍和疲劳)的影响之间的联系,揭示了营养状况、日常生活活动和运动症状严重程度之间的联系。三项研究发现,体重的变化与帕金森病患者行动问题相关症状的严重程度有关。三项研究调查了不同的帕金森病治疗方法之间的关系及其与体重和能量代谢变化之间的相互作用,强调帕金森病早期的体重减轻需要对不同的治疗方法进行充分监测,以及中枢神经系统和外周神经系统在调节这些过程中的相互作用。最后,有两项研究调查了胃肠道改变和微生物群变化与认知状态的关系,从而确定它们是帕金森病的风险因素和早期征兆:该系统综述强调了帕金森病患者的营养状况与生活质量之间的重要关系,以及帕金森病的治疗方法如何影响患者的体重。在肠道-大脑轴方面也观察到了关联,充足的营养状况影响了肠道微生物群的平衡,减缓了认知能力的下降,改善了日常生活活动,提高了帕金森病患者的生活质量。研究证实,患者的营养状况对疾病的运动症状和非运动症状都有影响,因此也影响了他们的生活质量。
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引用次数: 0
Cardiometabolic factors and vitamin D deficiency in pediatric patients with chronic kidney disease. 慢性肾病儿科患者的心脏代谢因素和维生素 D 缺乏症。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1480424
Israel Parra-Ortega, Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Miguel Klünder-Klünder, Jenny Vilchis-Gil, Carmen Zepeda-Martinez, Ángeles Rizo Romero, Gabriela Alegria-Torres, Benjamin Romero-Navarro, José Carlos Romo-Vázquez

Background: Patients with chronic kidney disease (CKD) are at increased risk for cardiovascular disease. Up to 80% of patients with CKD may exhibit inadequate vitamin D (VD) levels, which have been linked to the presence of cardiometabolic factors (CFs) in the adult population. However, research on this association in the pediatric population is limited.

Objective: To analyze the effects of 25-hydroxyvitamin D3 (25-[OH]D) levels and status on the presence of CFs in children receiving kidney replacement therapy (KRT).

Materials and methods: This cross-sectional study included pediatric patients receiving KRT, aged 8-17 years, who were receiving hemodialysis or peritoneal dialysis from January 2021 to March 2024. We conducted anthropometric measurements, blood pressure assessments, and glucose, 25-(OH)D, and lipid profiling for all participants. The daily dose of cholecalciferol supplementation, as well as other medications affecting bone and lipid metabolism and antihypertensive drugs, were documented. Statistical analyses were performed using Student's t-tests and chi-square tests to compare the CFs between groups with and without VD deficiency.

Results: The study involved 156 patients with an average age of 12.9 years and a mean serum VD level of 22.5 ng/dL. Patients with VD deficiency presented higher levels of total cholesterol and diastolic blood pressure (p < 0.05). No statistically significant differences were found in other biochemical profile variables or in the frequency of cardiometabolic factors.

Conclusion: Vitamin D deficiency seems to increase the risk of dyslipidemia and uncontrolled hypertension in children and adolescents with end-stage CKD.

背景:慢性肾脏病(CKD)患者罹患心血管疾病的风险增加。多达 80% 的慢性肾脏病患者可能表现出维生素 D (VD) 水平不足,这与成人心血管代谢因素 (CF) 的存在有关。然而,对儿科人群中这种关联的研究却很有限:分析 25- 羟维生素 D3(25-[OH]D)水平和状态对接受肾脏替代疗法(KRT)的儿童出现 CFs 的影响:这项横断面研究纳入了2021年1月至2024年3月期间接受血液透析或腹膜透析的8-17岁接受KRT的儿童患者。我们对所有参与者进行了人体测量、血压评估、血糖、25-(OH)D 和血脂分析。我们还记录了胆钙化醇的每日补充剂量,以及其他影响骨骼和脂质代谢的药物和降压药物。采用学生 t 检验和卡方检验进行统计分析,以比较有 VD 缺乏症和无 VD 缺乏症组之间的 CFs:研究涉及 156 名患者,他们的平均年龄为 12.9 岁,平均血清 VD 水平为 22.5 纳克/分升。维生素 D 缺乏症患者的总胆固醇和舒张压水平较高(p 结论:维生素 D 缺乏症似乎会增加儿童患心脏病的风险:维生素 D 缺乏似乎会增加终末期慢性肾脏病儿童和青少年血脂异常和高血压失控的风险。
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引用次数: 0
Navigating the online food environment: policy pathways for promoting food access, transparency, and healthy food choices online. 网上食品环境导航:促进食品获取、透明度和网上健康食品选择的政策途径。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-08 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1473303
Eva Greenthal, Katherine Marx, Emily Friedman, Sara John, Joelle Johnson, Christina LiPuma, DeAnna Nara, Sarah Sorscher, Karen Gardner, Aviva Musicus

The internet is drastically changing how U.S. consumers shop for groceries, order food from restaurants, and interact with food marketing. There is an urgent need for new policies to help ensure that the internet is a force for good when it comes to food access, transparency, and nutrition. This article outlines actions that federal agencies-like the U.S. Department of Agriculture (USDA), U.S. Food and Drug Administration (FDA), and Federal Trade Commission (FTC)-and state and local governments can take to improve the online food environment. We recommend policies in three settings: online grocery retail, online restaurant ordering, and marketing on social media and other online platforms. For example, USDA could finalize regulations increasing access to online WIC and remove barriers to accessing online SNAP by requiring large retailers to waive online delivery and service fees for SNAP purchases. FDA could improve access to nutrition information by issuing guidance describing what product information should be available at the online point of selection. FTC could give better guidance on appropriate tactics when marketing to children and collect better data on how companies are marketing food to children online. Finally, state governments could pass laws like New York's recently introduced Predatory Marketing Prevention Act to address false and misleading advertising of unhealthy foods aimed at children and other vulnerable groups.

互联网正在彻底改变美国消费者购买食品杂货、从餐馆订餐以及与食品营销互动的方式。当务之急是制定新政策,帮助确保互联网在食品获取、透明度和营养方面发挥积极作用。本文概述了联邦机构--如美国农业部(USDA)、美国食品和药物管理局(FDA)、联邦贸易委员会(FTC)--以及州和地方政府为改善网络食品环境可以采取的行动。我们建议在三种情况下制定相关政策:在线杂货零售、在线餐馆订餐以及在社交媒体和其他在线平台上进行营销。例如,美国农业部(USDA)可以最终确定相关法规,增加在线 WIC 的使用,并通过要求大型零售商免除 SNAP 购买的在线配送费和服务费,消除在线 SNAP 的使用障碍。美国食品和药物管理局(FDA)可以发布指导意见,说明在线选择点应提供哪些产品信息,从而改善营养信息的获取。联邦贸易委员会可以就向儿童营销时的适当策略提供更好的指导,并收集有关公司如何在网上向儿童营销食品的更好的数据。最后,各州政府可以通过像纽约州最近出台的《预防掠夺性营销法》这样的法律,来解决针对儿童和其他弱势群体的不健康食品的虚假和误导性广告问题。
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引用次数: 0
Comparative analysis of COVID-19 responses in Japan and Africa: diet, phytochemicals, vitamin D, and gut microbiota in reducing mortality-A systematic review and meta-analysis. 日本和非洲 COVID-19 反应的比较分析:饮食、植物化学物质、维生素 D 和肠道微生物群在降低死亡率方面的作用--系统综述和荟萃分析。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1465324
Kazuki Santa, Raita Tamaki, Kenji Watanabe, Isao Nagaoka

Background: As the novel coronavirus disease 2019 (COVID-19) pandemic subsides, the clinical sequelae are becoming more problematic. Interestingly, the statistical data indicate that Africa has experienced the lowest number of cases and deaths, with an unexpected phenomenon where the number of deaths from COVID-19 has not increased significantly. Several studies have investigated the relationship between diet and coronavirus. However, no systematic review/meta-analysis has conclusively linked diet (phytochemicals and vitamin D) and the gut microbiota in the context of COVID-19.

Methods: This study examined the responses to COVID-19 in Japan and Africa, formulating the following hypotheses: (1) a healthy diet is effective against COVID-19, (2) blood vitamin D levels are associated with COVID-19 mortality, and (3) COVID-19 is associated with the gut microbiota. To investigate these hypotheses, a keyword search and meta-analysis were conducted using PubMed, and each hypothesis was tested.

Results: This study found that a healthy diet, particularly rich in phytochemicals such as polyphenols and flavonoids, is effective against COVID-19. An association was detected between blood vitamin D levels and COVID-19 mortality. The gut microbiota was linked to COVID-19 and its amelioration. These findings may have significant implications for not only understanding COVID-19 but also future prevention of pneumonia.

背景:随着 2019 年新型冠状病毒病(COVID-19)大流行的消退,临床后遗症问题日益严重。有趣的是,统计数据显示,非洲的病例数和死亡人数都是最少的,而一个意想不到的现象是,死于 COVID-19 的人数并没有显著增加。有几项研究调查了饮食与冠状病毒之间的关系。然而,在 COVID-19 的背景下,还没有系统综述/总体分析将饮食(植物化学物质和维生素 D)与肠道微生物群确凿地联系起来:本研究考察了日本和非洲对 COVID-19 的反应,并提出以下假设:(1) 健康饮食能有效抵抗 COVID-19;(2) 血液中维生素 D 水平与 COVID-19 死亡率相关;(3) COVID-19 与肠道微生物群相关。为了研究这些假设,我们使用 PubMed 进行了关键词搜索和荟萃分析,并对每个假设进行了检验:研究发现,健康饮食,尤其是富含植物化学物质(如多酚和类黄酮)的饮食,能有效预防 COVID-19。血液中维生素 D 水平与 COVID-19 死亡率之间存在关联。肠道微生物群与 COVID-19 及其改善有关。这些发现不仅对了解 COVID-19 有重要意义,而且对今后预防肺炎也有重要意义。
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引用次数: 0
Body compositions phenotypes of older adults with COPD. 患有慢性阻塞性肺病的老年人的身体成分表型。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1449189
Aleksandra Kaluźniak-Szymanowska, Dorota Talarska, Sławomir Tobis, Arkadiusz Styszyński, Szczepan Cofta, Katarzyna Wieczorowska-Tobis, Ewa Deskur-Śmielecka

Purpose: Changes in nutritional status are important extrapulmonary manifestations of the chronic obstructive pulmonary disease (COPD). The study aimed to assess the prevalence of different body composition phenotypes in older patients with COPD and to investigate the relationship between these phenotypes and the severity of the disease, as well as physical performance of the subjects.

Patients and methods: The study included 124 subjects aged ≥60 with COPD. In all of them body composition analysis and muscle strength measurement were performed. Additionally, data from patients' medical records were analyzed. Study sample was divided into four groups based on the phenotypic body composition: normal phenotype (N), sarcopenia, obesity and sarcopenic obesity (SO).

Results: Incidence of sarcopenia was significantly higher in patients with severe or very severe COPD based on GOLD in comparison with subjects with mild or moderate obstruction (p = 0.043). Participants with sarcopenia, obesity and SO had lower results of the 6-min walk test than subjects with N (225.77 m, 275.33 m, 350.67 m, 403.56 m, respectively). Moreover, sarcopenia and SO had lower results than obesity (p = 0.001, p = 0.041, respectively).

Conclusion: Sarcopenia is common in patients with advanced COPD. Sarcopenia and SO are associated with poorer physical performance. All older people with COPD should routinely have their body composition assessed, instead of simply measuring of body weight or body mass index (BMI).

目的:营养状况的变化是慢性阻塞性肺疾病(COPD)的重要肺外表现。本研究旨在评估慢性阻塞性肺病老年患者不同身体成分表型的患病率,并调查这些表型与疾病严重程度以及受试者体能表现之间的关系:研究包括 124 名年龄≥60 岁的慢性阻塞性肺病患者。所有受试者都进行了身体成分分析和肌肉力量测量。此外,还分析了患者的医疗记录数据。研究样本根据表型身体成分分为四组:正常表型(N)、肌肉疏松症、肥胖症和肌肉疏松性肥胖症(SO):结果:与轻度或中度阻塞的受试者相比,根据 GOLD 标准,重度或极重度慢性阻塞性肺病患者的肌肉疏松症发病率明显更高(p = 0.043)。患有肌肉疏松症、肥胖症和慢性阻塞性肺病的受试者在 6 分钟步行测试中的成绩(分别为 225.77 米、275.33 米、350.67 米和 403.56 米)低于患有慢性阻塞性肺病的受试者。此外,肌肉疏松症和肥胖症的结果也低于肥胖症(分别为 p = 0.001、p = 0.041):结论:肌肉疏松症在晚期慢性阻塞性肺病患者中很常见。结论:在晚期慢性阻塞性肺病患者中,"肌肉疏松症 "和 "肥胖症 "很常见。所有患有慢性阻塞性肺病的老年人都应定期进行身体成分评估,而不是简单地测量体重或体重指数(BMI)。
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引用次数: 0
Associations of composite dietary antioxidant index with suicidal ideation incidence and mortality among the U.S. population. 美国人口中复合膳食抗氧化指数与自杀倾向发生率和死亡率的关系。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1457244
Shaoqun Huang, Weimin Zhao, Seok Choi, Hongyang Gong

Background: The relationship between CDAI and suicidal ideation is unclear. This study investigates the relationship between CDAI and suicidal ideation and examines the association between CDAI and all-cause mortality (ACM) or cardiovascular disease mortality (CVM) among participants with and without suicidal ideation.

Methods: Data from seven NHANES cycles (2005-2018) were analyzed using cross-sectional and prospective cohort studies. Weighted multivariable logistic regression models, restricted cubic spline (RCS) plots, and subgroup analyses explored the association between CDAI and suicidal ideation. Kaplan-Meier (KM) curves, weighted multivariable Cox proportional hazards models, and RCS assessed the relationship between CDAI and CVM or ACM.

Results: Among 30,976 participants aged over 20, 1,154 (3.72%) had suicidal ideation. Higher CDAI levels (Quartile 4) were associated with a 28% reduction in suicidal ideation compared to lower levels (Quartile 1). Over an average follow-up of 89 months, 3,267 participants (7.6%) died, including 808 (1.8%) from cardiovascular causes. Higher CDAI levels were linked to a 30, 68, and 28% reduction in ACM in the total population, those with suicidal ideation, and those without, respectively. CVM was reduced by 40% in the total population and by 41% in those without suicidal ideation.

Conclusion: CDAI is negatively associated with suicidal ideation and correlated with reduced ACM and CVM among participants with and without suicidal ideation.

背景:CDAI与自杀意念之间的关系尚不明确。本研究调查了CDAI与自杀意念之间的关系,并研究了有自杀意念和无自杀意念参与者的CDAI与全因死亡率(ACM)或心血管疾病死亡率(CVM)之间的关联:利用横断面和前瞻性队列研究分析了七个 NHANES 周期(2005-2018 年)的数据。加权多变量逻辑回归模型、受限立方样条曲线(RCS)图和亚组分析探讨了 CDAI 与自杀意念之间的关联。Kaplan-Meier (KM) 曲线、加权多变量 Cox 比例危险模型和 RCS 评估了 CDAI 与 CVM 或 ACM 之间的关系:在 30976 名 20 岁以上的参与者中,有 1154 人(3.72%)有自杀倾向。与较低的水平(四分位数 1)相比,较高的 CDAI 水平(四分位数 4)与自杀意念减少 28% 相关。在平均 89 个月的随访期间,共有 3267 名参与者(7.6%)死亡,其中 808 人(1.8%)死于心血管疾病。CDAI 水平越高,总人口、有自杀意念者和无自杀意念者的 ACM 分别减少 30%、68% 和 28%。CVM在总人群中降低了40%,在无自杀倾向的人群中降低了41%:CDAI与自杀倾向呈负相关,在有自杀倾向和无自杀倾向的参与者中,CDAI与ACM和CVM的减少相关。
{"title":"Associations of composite dietary antioxidant index with suicidal ideation incidence and mortality among the U.S. population.","authors":"Shaoqun Huang, Weimin Zhao, Seok Choi, Hongyang Gong","doi":"10.3389/fnut.2024.1457244","DOIUrl":"10.3389/fnut.2024.1457244","url":null,"abstract":"<p><strong>Background: </strong>The relationship between CDAI and suicidal ideation is unclear. This study investigates the relationship between CDAI and suicidal ideation and examines the association between CDAI and all-cause mortality (ACM) or cardiovascular disease mortality (CVM) among participants with and without suicidal ideation.</p><p><strong>Methods: </strong>Data from seven NHANES cycles (2005-2018) were analyzed using cross-sectional and prospective cohort studies. Weighted multivariable logistic regression models, restricted cubic spline (RCS) plots, and subgroup analyses explored the association between CDAI and suicidal ideation. Kaplan-Meier (KM) curves, weighted multivariable Cox proportional hazards models, and RCS assessed the relationship between CDAI and CVM or ACM.</p><p><strong>Results: </strong>Among 30,976 participants aged over 20, 1,154 (3.72%) had suicidal ideation. Higher CDAI levels (Quartile 4) were associated with a 28% reduction in suicidal ideation compared to lower levels (Quartile 1). Over an average follow-up of 89 months, 3,267 participants (7.6%) died, including 808 (1.8%) from cardiovascular causes. Higher CDAI levels were linked to a 30, 68, and 28% reduction in ACM in the total population, those with suicidal ideation, and those without, respectively. CVM was reduced by 40% in the total population and by 41% in those without suicidal ideation.</p><p><strong>Conclusion: </strong>CDAI is negatively associated with suicidal ideation and correlated with reduced ACM and CVM among participants with and without suicidal ideation.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142462132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Life's Essential 8 to metabolic syndrome: insights from NHANES database and network pharmacology analysis of quercetin. 从 "生命之源 8 "到代谢综合征:从 NHANES 数据库和槲皮素网络药理学分析中获得的启示。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1452374
Runze Zhang, Xiuxiu Qiu, Chenming He, Rou Deng, Chenxing Huo, Bangjiang Fang
<p><strong>Background: </strong>Metabolic syndrome (MetS), or syndrome X, is a collection of metabolic illnesses that affect the body's health, particularly insulin resistance and obesity. The prevalence of MetS is on the rise, particularly among younger individuals. Quercetin, a natural flavonoid found in many traditional Chinese medicines, can impact various pathways to disrupt the pathological advancement of MetS with few negative effects. The American Heart Association recently introduced a cardiovascular health assessment termed Life's Essential 8 (LE8), which might impact the treatment of MetS.</p><p><strong>Methods: </strong>Quercetin targets and their functions in MetS pathways were identified using a network pharmacology method and molecular docking techniques. The study examined quercetin's direct and indirect interactions with proteins linked to the pathogenic processes of MetS. Data were collected regarding the American Heart Association's LE8 cardiovascular health indicators, which include health behaviors (diet, physical activity, nicotine exposure, and sleep) and health factors (body mass index, non-high-density lipoprotein cholesterol, blood glucose, and blood pressure). The study assessed the connection between LE8 and the occurrence of MetS, taking into account dietary quercetin consumption as a variable of interest.</p><p><strong>Results: </strong>The negative correlation between MetS and LE8 indicates that individuals with higher LE8 scores are less likely to develop MetS. Individuals in the fully adjusted highest group (LE8 ≥ 80) demonstrated a 79% lower likelihood of developing MetS than those in the lowest group (OR = 0.21; 95% CI, 0.17-0.26, <i>p</i> < 0.0001). Network pharmacology and molecular docking results show that quercetin may exert its therapeutic effects by modulating various biological response processes, including those related to xenobiotic stimuli, bacterial molecules, lipopolysaccharides, and oxidative stimuli. These processes involve key pathways associated with diabetic complications, such as the AGE-RAGE signaling pathway, pathways related to diabetic complications, and pathways involved in lipids and atherosclerosis. Therefore, quercetin may reduce cardiovascular risk, improve glucose-lipid metabolism, and alleviate insulin resistance and other biological processes by influencing multiple aspects of the lipid profile, blood glucose, and insulin resistance, ultimately impacting the links between LE8 score and MetS.</p><p><strong>Conclusion: </strong>This study discovered that an optimal LE8 score is a marker of adopting a lifestyle of wellness and is connected with a reduced likelihood of developing MetS. Quercetin acts on core targets such as IL6, BCL2, TP53, IL1B, MAPK1, and CCL2, and then plays a therapeutic role in regulating lipid metabolism, anti-inflammation, immunomodulation, autophagy, etc., through the pathways of diabetic complications, lipids, atherosclerosis, etc., and has the characteristics
背景:代谢综合征(MetS)或 X 综合征是一系列影响人体健康的代谢疾病,尤其是胰岛素抵抗和肥胖。代谢综合征的发病率呈上升趋势,尤其是在年轻人中。槲皮素是一种存在于许多传统中药中的天然类黄酮,它可以影响各种途径,从而阻断 MetS 的病理发展,而且几乎不会产生负面影响。美国心脏协会最近推出了一项名为 "生命必需 8"(LE8)的心血管健康评估,这可能会对 MetS 的治疗产生影响:方法:采用网络药理学方法和分子对接技术确定了槲皮素在 MetS 通路中的靶点及其功能。研究考察了槲皮素与 MetS 致病过程相关蛋白的直接和间接相互作用。研究收集了有关美国心脏协会 LE8 心血管健康指标的数据,其中包括健康行为(饮食、体力活动、尼古丁接触和睡眠)和健康因素(体重指数、非高密度脂蛋白胆固醇、血糖和血压)。研究评估了 LE8 与 MetS 发生之间的联系,并将膳食中槲皮素的摄入量作为一个变量加以考虑:MetS 与 LE8 之间的负相关表明,LE8 分数越高的人患 MetS 的可能性越小。完全调整后的最高组(LE8 ≥ 80)比最低组的人患 MetS 的可能性低 79%(OR = 0.21;95% CI,0.17-0.26,p 结论:该研究发现,LE8 ≥ 80 的人患 MetS 的可能性比 LE8 ≥ 80 的人低 79%(OR = 0.21;95% CI,0.17-0.26,p):这项研究发现,LE8 的最佳得分是采取健康生活方式的标志,并与代谢综合征的发病可能性降低有关。槲皮素作用于IL6、BCL2、TP53、IL1B、MAPK1、CCL2等核心靶点,通过糖尿病并发症、血脂、动脉粥样硬化等通路,在调节脂质代谢、抗炎、免疫调节、自噬等方面发挥治疗作用,具有多靶点、多通路、多功能的特点,可用于MetS的调控干预。
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引用次数: 0
Demystifying the nutritional and anti-nutritional genetic divergence of Pakistani chickpea (Cicer arietinum L.) genetic resource via multivariate approaches. 通过多变量方法揭示巴基斯坦鹰嘴豆(Cicer arietinum L.)遗传资源的营养和抗营养遗传差异。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-04 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1407096
Saima Jameel, Amjad Hameed, Tariq Mahmud Shah, Clarice J Coyne

Chickpeas are a highly versatile functional food legume that possesses the capacity to boost human health and has the potential to alleviate malnutrition-related deficiencies. To investigate whole seed-based nutritional and anti-nutritional composition, a set of 90 chickpea genotypes (66 desi and 24 kabuli) was collected from different research organizations in Pakistan. Significant variation (Tukey HSD test, p < 0.05) was perceived among genotypes for traits under investigation. The genotypes, with maximum total soluble proteins (TSPs) (34.92%), crude proteins (CPs) (30.13%), and reducing sugars (17.33 mg/g s. wt.), i.e., Punjab-2000 (desi); total free amino acids (TFAs) (3.34 g/100 g DW), i.e., Wild Hybrid-15 (desi), albumins (227.67 mg/g s. wt.), i.e., Sheenghar-2000 (desi); globulins (720 g s. wt.), i.e., ICCV-96030 (desi); salt-soluble proteins (200 mg/g s. wt.), i.e., ILWC-247 (desi); total soluble sugars (TSSs) (102.63 mg/g s. wt.), i.e., CM1051/11 (desi); non-reducing sugars (95.28 mg/g s. wt.), i.e., NIAB-CH2016 (desi); starch content (83.69%), i.e., CH55/09 (kabuli); and the genotypes with least value of anti-nutritional factors glutelin (3.33 mg/g s. wt.), i.e., Wild Hybrid-9 (desi); hordein (1.38 mg/g s. wt.), i.e., Noor-2013 (kabuli); tannins (5,425 uM/g s. wt.), i.e., Wild Hybrid-1 (desi); and phytic acid (PA) (0.18 mg/g s. wt.), i.e., Bhakhar-2011 (desi), could be the promising genotypes to formulate health-promoting plant-based food products. Data were also analyzed for principal component analysis (PCA), correlation, and agglomerative hierarchical clustering. PC-1 revealed the highest contribution (20.83%) toward cumulative variability, and maximum positive factor loading was delivered by TSSs (0.85) followed by starch content (0.729). Genotypes were grouped into three distinct clusters based on high average values of traits under investigation. Cluster I encompassed genotypes with a high mean value of CP content, albumins, hordein, and glutelin; Cluster II encompassed genotypes with a high mean value of TSPs, TSSs, non-reducing sugars, globulins, salt-soluble sugars, starch, and TFAs; Cluster III encompassed genotypes with high tannins, reducing sugars, and PA. Identified desi and kabuli genotypes exhibiting superior seed quality traits and minimal anti-nutritional factors can be used in chickpea breeding programs aimed at improving seed nutritional quality in future breeding lines.

鹰嘴豆是一种用途广泛的功能性豆类食品,具有促进人类健康的能力,并有可能缓解与营养不良有关的缺乏症。为了研究鹰嘴豆的全籽营养成分和抗营养成分,我们从巴基斯坦不同的研究机构收集了 90 种鹰嘴豆基因型(66 种 desi 和 24 种 kabuli)。显著差异(Tukey HSD 检验,p
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引用次数: 0
Effects of quinoa on cardiovascular disease and diabetes: a review. 藜麦对心血管疾病和糖尿病的影响:综述。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-04 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1470834
Li Ruiqi, Zhang He

Quinoa is an annual dicotyledonous plant belonging to the genus Chenopodiaceae. As a functional healthy food with outstanding nutritional value, quinoa contains not only a balanced proportion of amino acids but also higher contents of protein, unsaturated fatty acids, vitamins, and minerals (K, P, Mg, Ca, Zn, and Fe) than most cereal crops. Quinoa is also rich in active ingredients, such as polyphenols, flavonoids, saponins, polysaccharides, peptides, and ecdysone, which provide balanced nutrition, enhance the body function, regulate blood sugar, decrease blood lipid, increase anti-oxidation and anti-inflammatory action, and prevent and treat cardiovascular diseases. Thus, quinoa is especially suitable for people suffering from chronic diseases, such as diabetes, hypertension, hyperlipidemia, and heart disease, and for the elderly people. Because of its comprehensive nutritional value and edible functional characteristics, quinoa is better than most grains and has become a highly nutritious food suitable for human consumption. This article reviews the active ingredients and physiological functions of quinoa, aiming to provide a reference for further research and its utilization in food, healthcare, and pharmaceutical research and development.

藜麦是一种一年生双子叶植物,属于藜科(Chenopodiaceae)藜属(Chenopodiaceae)。作为一种营养价值突出的功能性健康食品,藜麦不仅氨基酸比例均衡,而且蛋白质、不饱和脂肪酸、维生素和矿物质(钾、磷、镁、钙、锌和铁)的含量也高于大多数谷类作物。藜麦还含有丰富的活性成分,如多酚、类黄酮、皂苷、多糖、肽和蜕皮激素等,可提供均衡营养,增强机体功能,调节血糖,降低血脂,增强抗氧化和抗炎作用,预防和治疗心血管疾病。因此,藜麦特别适合糖尿病、高血压、高脂血症、心脏病等慢性病患者和老年人食用。藜麦因其全面的营养价值和可食用的功能特点,优于大多数谷物,已成为适合人类食用的高营养食品。本文综述了藜麦的有效成分和生理功能,旨在为进一步研究和利用藜麦进行食品、保健和医药研发提供参考。
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引用次数: 0
The association of dietary insulinemic indices with PI3K, PTEN, and Akt gene expressions in visceral and subcutaneous adipose tissues among individuals undergoing abdominal surgery. 接受腹部手术者的饮食胰岛素血症指数与内脏和皮下脂肪组织中 PI3K、PTEN 和 Akt 基因表达的关系。
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2024-10-04 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1467686
Hamid Ahmadirad, Farshad Teymoori, Hossein Farhadnejad, Ghazaleh Shimi, Golaleh Asghari, Emad Yuzbashian, Maryam Zarkesh, Parvin Mirmiran, Alireza Khalaj

Background/objective: The current study investigates the association between dietary insulinemic indices and Akt, PTEN, and PI3K gene expressions in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) among individuals undergoing abdominal surgery.

Materials and methods: This cross-sectional study was conducted on 176 individuals, aged 18-84 years, who had undergone abdominal surgery. The participants were classified based on body mass index (BMI) as normal (BMI < 25 kg/m2), overweight (BMI = 25-29.9 kg/m2), and obese (BMI ≥ 30 kg/m2). The food frequency questionnaire was used to determine dietary glycemic and insulinemic indices. Real-time polymerase chain reaction was conducted for the expression of PI3K, PTEN, and Akt genes.

Results: In the final adjusted model, in normal-weight patients, there was an inverse relationship between the lifestyle with a higher insulinemic potential and the PI3K gene expression in VAT. In addition, there was an inverse association between dietary insulin load and the Akt gene expression in VAT. However, a higher glycemic index was positively associated with the PTEN gene expression in VAT. In overweight patients, a high insulinemic potential of the diet was associated with higher PTEN gene expression in VAT. In obese individuals, there were positive associations between lifestyle index for insulin resistance and hyperinsulinemia and the PI3K gene expression in VAT. Moreover, the higher insulinemic potential of diet and lifestyle was positively related to a higher expression of the PTEN and Akt genes in VAT.

Conclusion: Our findings revealed that high insulinemic lifestyles and dietary patterns may be related to the expression of PI3K, PTEN, and Akt in adipose tissues.

背景/目的:本研究调查了接受腹部手术的个体中饮食胰岛素血症指数与内脏脂肪组织(VAT)和皮下脂肪组织(SAT)中 Akt、PTEN 和 PI3K 基因表达之间的关系:这项横断面研究的对象是 176 名接受过腹部手术的人,年龄在 18-84 岁之间。根据体重指数(BMI)将参与者分为正常(BMI 2)、超重(BMI = 25-29.9 kg/m2)和肥胖(BMI ≥ 30 kg/m2)。食物频率问卷用于确定膳食血糖和胰岛素指数。对 PI3K、PTEN 和 Akt 基因的表达进行了实时聚合酶链反应:结果:在最终调整模型中,正常体重患者的胰岛素血症潜能值较高的生活方式与 VAT 中 PI3K 基因的表达呈反比关系。此外,膳食中的胰岛素负荷与腹大肌中的 Akt 基因表达呈反向关系。然而,较高的血糖指数与血管内皮生长因子基因表达呈正相关。在超重患者中,膳食中的高胰岛素血症潜能值与 VAT 中较高的 PTEN 基因表达有关。在肥胖者中,胰岛素抵抗和高胰岛素血症的生活方式指数与 VAT 中的 PI3K 基因表达呈正相关。此外,饮食和生活方式中较高的胰岛素血症潜能值与 VAT 中较高的 PTEN 和 Akt 基因表达呈正相关:我们的研究结果表明,高胰岛素血症生活方式和饮食模式可能与脂肪组织中 PI3K、PTEN 和 Akt 的表达有关。
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引用次数: 0
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Frontiers in Nutrition
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