{"title":"臨床黴菌學(真菌學)研究室30年來工作之回顧","authors":"任天民","doi":"10.7099/FS.199512.0053","DOIUrl":"https://doi.org/10.7099/FS.199512.0053","url":null,"abstract":"本室擔負數學、檢驗、醫療及醫學研究等任務至今已逾30年之久!從公元1961年到1994年,本室經天民創辨後在臺灣分離成功之致病性或機會致病性(opportunistic)黴菌而具臨床診治意義且可符合美國醫用黴菌學專家(Conant, 1962; Ajello, 1962),或符合國際人類及動物黴菌學會(ISHAM: International Society for Human and Animal Mycology)之專家如Odds、Arai、Disalvo、Evans、Hay、Randhawa、Rinaldi及Walsh近來(1992)之建議標準者,計有36種株(species)及尚未确定種株之9屬(genus)之多。此等黴菌會引起淺部,皮下組織,深部或系統性及機會致病性等各種黴菌病以及黴菌菌血症。計有: Absidia corymbifera、Alternaria alternata、Aspergillus、A. flavus (animal model)、A. fumigatus、Candida albicans、C. famata、C. glabrata、C. guilliermondii、C. krusei、C. lusitaniae、C. parakrusei、C. parapsilosis、C. stellatoidea、C. tropicalis、Cladosporium Link-VGH、Taipei (?)、C. werneckii、Coccidioides immitis、Cryptococcus albidus、C. neoformans、C. neoformans var. sinensis、dermatophytes including Epidermophyton floccosum、Microsporum canis、M. ferrugineum、M. gypseum、Trichophyton mentagrophytes var. granular、T. mentagrophytes var. interdigitale、T. rubrum、T. violaceum、Fonsecaea pedrosoi、Fusarium、Geotrichum candidum、Malassezia furfur、Mucor、Nocardia asteroidesm Paecilomyces、Penicillium、P. marneffei、Rhizopus、Rhodotorula、R. rubra、Scopulariopsis、Sporothrix schenckii、Trichosporon beigelii 及 Wangiella dermatitidis。以本室所改進之黴菌學檢驗技術名稱而言,則有過碘酸薔薇苯胺抹片染色法(PAS smear exam),試管內氫氧化鉀濕片製備法,瑞士小白鼠(Swiss mouse)之靜脈注射法,羊毛絨線(wool-fiber)酵母浸液體培養基餌(baiting)菌法,以及白色念珠菌(Candida albicans)之孢子,芽管細胞(germ tube cells)及厚膜分生子(chlamydoconidia)對抗黴藥物之試驗法等。本室且會與其他科室合作,使用若干分子生物學法對白色念珠茵及其他酵母菌用鑑定之用。本室會對下死藥物進行抗黴試驗(antifungal susceptibility tests);對國人有效者有Amphotericin B、Nystatin、5-fluorocytosine、Griseofulvin、Siccanin、Itraconazole及Lamisil。雖非抗黴藥物卻經本人首先發現其抗黴作用者計有Gamastan (Cutter)、Gentamicin及Vitamin K3。","PeriodicalId":12667,"journal":{"name":"Fungal Science","volume":"7 1","pages":"53-67"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89574733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0