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Knowledge of Air Pollution and its Predictors among Traders in Douglas Market, Imo State, South–Eastern Nigeria 尼日利亚东南部伊莫州道格拉斯市场贸易商对空气污染及其预测因素的了解
Pub Date : 2023-12-21 DOI: 10.9734/ijtdh/2023/v44i241506
Oluoha R. U., Offiong A. A., Nzomiwu D. C., Nsodukwa C. O.
Background: Air pollution is currently a major threat globally, particularly in a developing country such as Nigeria. With its dire implication for human health, it is imperative to study and understand the knowledge and contributory practices of the populace as key to the development of necessary intervention measures. Aims and Objectives: To assess knowledge and its predictors, also contributory practices towards air pollution among traders in Douglas Market, Owerri, Imo State, Nigeria. Methodology: A cross – sectional analytical design using a combination of cluster and simple random sampling techniques were used to select 200 participants. Data was collected using a pretested semi – structured interviewer administered questionnaire. Descriptive analysis was done with frequencies and summary statistics. Chi square statistics were computed to determine significant relationship and simple binary regression was used to determine predictors of knowledge of air pollution. The p – value was set at 0.05 significance level. Result: The mean age of the respondents was 36.2 ± 10.4 years with a slightly higher female proportion (59.0%). Almost all the respondents (97.9%) are aware of air pollution and the most common sources of information were the social media (38.8%) and the internet (23.2%). Respondents with good knowledge of air pollution in this study stood at 84.1%. Use of generators (73.5%) was the most common source of air pollution among the study participants. Factors significantly associated with knowledge of air pollution were age (p = 0.0000), marital status (p = 0.0192) and level of education (p = 0.0000). Predictors of poor knowledge of air pollution were: being within the ages of 42 – 49 years (OR: 27.33) and having non – formal education (OR: 32.50). Conclusion: There is overall good knowledge of air pollution, however there was still relatively low knowledge in the less educated and elderly populace. This should inform policy making with targeted advocacy towards the education and guidance of people to become knowledgeable about air pollution and related health risks. Also efficient generation and supply of power will reduce the use of generators.
背景:空气污染是目前全球面临的主要威胁,尤其是在尼日利亚这样的发展中国家。由于其对人类健康的严重影响,研究和了解民众对空气污染的认识和相关做法是制定必要干预措施的关键。目的和目标:评估尼日利亚伊莫州欧韦里市道格拉斯市场商贩对空气污染的认识及其预测因素,以及促成空气污染的做法。研究方法:采用集群和简单随机抽样相结合的横断面分析设计,选出 200 名参与者。数据收集采用了一份经过预先测试的半结构化访谈问卷。使用频率和摘要统计进行了描述性分析。通过计算卡方统计来确定显著关系,并使用简单的二元回归来确定空气污染知识的预测因素。P 值设定为 0.05 的显著性水平。结果受访者的平均年龄为 36.2 ± 10.4 岁,女性比例略高(59.0%)。几乎所有受访者(97.9%)都了解空气污染,最常见的信息来源是社交媒体(38.8%)和互联网(23.2%)。在本研究中,对空气污染有较好认识的受访者占 84.1%。使用发电机(73.5%)是研究参与者中最常见的空气污染源。年龄(p = 0.0000)、婚姻状况(p = 0.0192)和受教育程度(p = 0.0000)是与空气污染知识明显相关的因素。空气污染知识贫乏的预测因素是:年龄在 42 - 49 岁之间(OR:27.33)和受过非正规教育(OR:32.50)。结论总体而言,人们对空气污染的了解程度较高,但受教育程度较低的人群和老年人对空气污染的了解程度相对较低。因此,在制定政策时应有针对性地进行宣传,教育和引导人们了解空气污染及相关健康风险。此外,高效的发电和供电将减少发电机的使用。
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引用次数: 0
Prevalence of Malaria Parasitaemia and Intestinal Protozoan Infections among Schoolchildren in Ndop, Northwest Cameroon, A Conflict Hit Locality 喀麦隆西北部冲突重灾区恩多普学龄儿童疟疾寄生虫血症和肠道原生动物感染的流行情况
Pub Date : 2023-12-21 DOI: 10.9734/ijtdh/2023/v44i241505
Calvin Bisong Ebai, F. N. Ngoufo, O. N. Nlinwe, Jennifer Acho Mefoumanyi, C. Yamssi, H. Kimbi
Aims: The aim of this study was to investigate the prevalence and factors associated with malaria and intestinal protozoans among schoolchildren in Ndop a conflict hit locality in Northwest Cameroon. Study Design: This was a school-based cross-sectional study. Place and Duration of Study: This study was carried out at the Cameroon Baptist Convention Nursery and Primary School Bamunka, Ndop during the months of April and May 2023. Methodology: Sociodemographic and hygiene-related data was collected using a structured questionnaire. Capillary blood and stool samples were collected, giemsa-stained blood films were examined to detect malaria parasites, while normal saline and iodine wet preparations were used to detect intestinal parasites in stool. Data was analyzed using SPSS version 22.0. The Chi-square test was used to compare prevalence between groups, p values less than 0.05 were considered statistically significant. Results: One hundred and eighty (180) children took part in the study. The prevalence of malaria, intestinal protozoans, and malaria and intestinal protozoan coinfection observed were 7.2%, 13.0%, and 1.5% respectively. Plasmodium falciparum was the only Plasmodium species identified while the intestinal protozoans observed were Entamoeba histolytica (9, 6.9%), Entamoeba coli (12, 9.1%) and Giardia lamblia (10, 7.6%). With respect to socio-demographic characteristics, father’s profession (p=0.04) and, class of children (p=.01); whereas for methods related to prevention, taking anti-helminthics (p=.001), having a toilet at home (p=.001), toilet type (p=.000), washing of hands at school (p=.001), washing of hands at home (p=.001) and source of water were associated with intestinal parasite prevalence.   Conclusion: This study revealed that malaria parasite and intestinal protozoans still constitute public health problems in Ndop. Control measures implemented by government to curb the prevalence of helminthic infections are quite effective meanwhile there is need to maintain and re-enforce measures for the control of malaria and intestinal protozoans.
研究目的:本研究旨在调查喀麦隆西北部冲突重灾区恩多普(Ndop)学龄儿童中疟疾和肠道原生动物的流行情况及其相关因素。研究设计:这是一项以学校为基础的横断面研究。研究地点和时间:研究于 2023 年 4 月至 5 月在恩多普的喀麦隆浸信会巴蒙卡幼儿园和小学进行。研究方法:使用结构化问卷收集社会人口学和卫生相关数据。收集毛细血管血液和粪便样本,检查革兰氏染色血片以检测疟原虫,使用生理盐水和碘湿制剂检测粪便中的肠道寄生虫。数据使用 SPSS 22.0 版进行分析。采用卡方检验比较各组之间的感染率,P 值小于 0.05 视为具有统计学意义。结果180名儿童参加了研究。观察到的疟疾、肠道原生动物以及疟疾和肠道原生动物合并感染的发病率分别为 7.2%、13.0% 和 1.5%。恶性疟原虫是唯一确定的疟原虫种类,而观察到的肠道原生动物有组织溶解恩塔米巴虫(9,6.9%)、大肠恩塔米巴虫(12,9.1%)和蓝氏贾第鞭毛虫(10,7.6%)。在社会人口特征方面,父亲的职业(p=0.04)和子女的班级(p=0.01);而在预防方法方面,服用抗蠕虫药(p=0.001)、家中有厕所(p=0.001)、厕所类型(p=0.000)、在学校洗手(p=0.001)、在家中洗手(p=0.001)和水源与肠道寄生虫的感染率有关。 结论这项研究表明,疟原虫和肠道原生动物仍然是恩多普的公共卫生问题。政府为遏制蠕虫感染流行而实施的控制措施相当有效,但仍有必要保持和加强疟疾和肠道原生动物的控制措施。
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引用次数: 0
Trends in ITN Use Prevalence among Children Attending for Malaria Diagnosis in the Main Sentinel Site for Malaria Surveillance of Gabon: Data from 2010 to 2020 加蓬疟疾监测主要哨点儿童疟疾诊断时使用驱虫蚊帐的趋势:2010 年至 2020 年的数据
Pub Date : 2023-12-18 DOI: 10.9734/ijtdh/2023/v44i241504
Bridy Chesly Moutombi Ditombi, Coella Joyce Mihindou, F. B. B. Ognagosso, Dimitri Ardin Mabika Moussavou, O. M. Nguema, N. P. M'Bondoukwé, J. M. N. Ngomo, Charleine Manomba Boulingui, Michèle Marion Ntsame Owone, Magalie Essomeyo Mebale, M. Bouyou-Akotet, D. Mawili-Mboumba
Aim: The aim of this study was to assess the trends of ITN use and age disparities among children attending for malaria diagnosis in the main sentinel site for malaria surveillance of Gabon. Methodology: Data were collected from September 2023 to October 2023 at the malaria sentinel site for malaria survey of the Regional Hospital of Melen in Gabon. Data from 2010 to 2020, including age, gender, years of screening and ITN use the night before the consultation were reported on a case report form. Results: Data from 13687 children were analyzed, the rate of ITN use was 57.7% (n=7902). The trend of ITN use decreased significantly from 76.2% in 2011 to 41.9% in 2017, with a slight increase until 2019 (54.9%). According to age, use of ITN was more frequently reported in infants (64.1%) and children aged between 2 to less than 5 years (57.1%) compared to older children (53.1%) and adolescents (51.2%) (P<0.01). Although the rate of mosquito net use significantly decreased in all the age groups, the odds of net use remained the highest in children under 5 years and lowest among the adolescents (P<0.01). Conclusion: The ITN use coverage is still insufficient in Libreville. Efforts should be done to achieve the universal coverage of ITN ownership and use toreduce malaria transmission in Gabon.
目的:本研究旨在评估加蓬疟疾监测主要哨点儿童使用驱虫蚊帐的趋势和年龄差异。研究方法:从 2023 年 9 月至 2023 年 10 月,在加蓬梅伦地区医院的疟疾调查哨点收集数据。病例报告表中报告了 2010 年至 2020 年的数据,包括年龄、性别、筛查年限和就诊前一晚使用驱虫蚊帐的情况。结果:分析了 13687 名儿童的数据,其中使用 ITN 的比例为 57.7%(n=7902)。使用 ITN 的趋势明显下降,从 2011 年的 76.2% 降至 2017 年的 41.9%,直到 2019 年(54.9%)才略有上升。根据年龄划分,与年龄较大的儿童(53.1%)和青少年(51.2%)相比,婴儿(64.1%)和 2 至 5 岁以下的儿童(57.1%)更经常使用 ITN(P<0.01)。尽管所有年龄组的蚊帐使用率都明显下降,但 5 岁以下儿童使用蚊帐的几率仍然最高,而青少年使用蚊帐的几率最低(P<0.01)。结论:利伯维尔的驱虫蚊帐使用覆盖率仍然不足。应努力实现拥有和使用驱虫蚊帐的全民覆盖,以减少疟疾在加蓬的传播。
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引用次数: 0
Knowledge, Attitude and Practice of Children (5 to 14 Years) in Relation to Predisposing Factors and Prevention of Soil-transmitted Helminth Infections in South West Region, Cameroon 喀麦隆西南部地区儿童(5 至 14 岁)对土壤传播螺旋体感染的易感因素和预防的认识、态度和做法
Pub Date : 2023-12-16 DOI: 10.9734/ijtdh/2023/v44i231502
Kfu Emmanuel Keng, J. L. Ndamukong-Nyanga, D. Nji, Nyambi Ali Margaret
Soil-transmitted helminths (STHs) diseases are among the group of Neglected Tropical Diseases (NTD). STHs infections are a significant public health problem globally with children being the most affected group. This study aimed to assess the knowledge, attitude and practice in relation to predisposing factors and preventive measures for STHs among children 4 to 15 years in Mutegene community. It was a cross-sectional study, involving 250 school children of both sexes. A systematic random sampling method was used to collect data. Basic demographic data was obtained from the class registers. A structured questionnaire was used to collect information on personal bio-data, characteristics of their home and school environment in relation to helminthes transmission and prevention. Data was analysed using SPSS version 21 and Chi-square test.  The results showed that 44.4 % (n=109) of the participants had good knowledge of parasitic worms, and 62.0 % (n=155) of the participants knew how to avoid getting infected with worms. Soil-transmitted helminth infection was present in Mutengene community with an overall prevalence of 3.6% and the species present included A. lumbricoides, T. trichiura, and hookworms. Participants who indicated that they played out-doors had the highest prevalence (2.8%, n=7) closely followed by those who usually played in water (2.4%, n=6) and thirdly, by those who always put dirt in their mouth (2.0%, n=5). At the end of the study, the researchers ecommended that health education should be given through community radios and televisions as a means of making the people understand the mode of transmission and methods of prevention of STH infection in order to eliminate STHs.
土壤传播蠕虫(STHs)疾病属于被忽视的热带疾病(NTD)。在全球范围内,经土壤传播的蠕虫感染是一个重大的公共卫生问题,儿童是受影响最大的群体。这项研究旨在评估穆特金社区 4-15 岁儿童对性传播疾病易感因素和预防措施的了解、态度和实践。这是一项横断面研究,涉及 250 名男女学童。研究采用系统随机抽样法收集数据。基本人口统计学数据来自班级登记册。采用结构化问卷收集个人生物数据、与螺旋体传播和预防有关的家庭和学校环境特征等信息。数据采用 SPSS 21 版和卡方检验进行分析。 结果显示,44.4%的参与者(人数=109)对寄生蠕虫有较好的了解,62.0%的参与者(人数=155)知道如何避免感染蠕虫。穆滕盖内社区存在土壤传播蠕虫感染,总感染率为 3.6%,感染的蠕虫种类包括蛔虫、毛滴虫和钩虫。表示在户外玩耍的参与者感染率最高(2.8%,人数=7),紧随其后的是通常在水中玩耍的参与者(2.4%,人数=6),第三是经常将污物放入口中的参与者(2.0%,人数=5)。研究结束时,研究人员建议通过社区广播和电视开展健康教育,使人们了解性传播疾病的传播方式和预防方法,以消除性传播疾病。
{"title":"Knowledge, Attitude and Practice of Children (5 to 14 Years) in Relation to Predisposing Factors and Prevention of Soil-transmitted Helminth Infections in South West Region, Cameroon","authors":"Kfu Emmanuel Keng, J. L. Ndamukong-Nyanga, D. Nji, Nyambi Ali Margaret","doi":"10.9734/ijtdh/2023/v44i231502","DOIUrl":"https://doi.org/10.9734/ijtdh/2023/v44i231502","url":null,"abstract":"Soil-transmitted helminths (STHs) diseases are among the group of Neglected Tropical Diseases (NTD). STHs infections are a significant public health problem globally with children being the most affected group. This study aimed to assess the knowledge, attitude and practice in relation to predisposing factors and preventive measures for STHs among children 4 to 15 years in Mutegene community. \u0000It was a cross-sectional study, involving 250 school children of both sexes. A systematic random sampling method was used to collect data. Basic demographic data was obtained from the class registers. A structured questionnaire was used to collect information on personal bio-data, characteristics of their home and school environment in relation to helminthes transmission and prevention. Data was analysed using SPSS version 21 and Chi-square test.  \u0000The results showed that 44.4 % (n=109) of the participants had good knowledge of parasitic worms, and 62.0 % (n=155) of the participants knew how to avoid getting infected with worms. Soil-transmitted helminth infection was present in Mutengene community with an overall prevalence of 3.6% and the species present included A. lumbricoides, T. trichiura, and hookworms. Participants who indicated that they played out-doors had the highest prevalence (2.8%, n=7) closely followed by those who usually played in water (2.4%, n=6) and thirdly, by those who always put dirt in their mouth (2.0%, n=5). \u0000At the end of the study, the researchers ecommended that health education should be given through community radios and televisions as a means of making the people understand the mode of transmission and methods of prevention of STH infection in order to eliminate STHs.","PeriodicalId":126794,"journal":{"name":"International Journal of TROPICAL DISEASE &amp; Health","volume":"46 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138967187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune Haemolytic Anaemia as Initial and Only Presentation of Systemic Lupus Erythematosus: A Case Report 自身免疫性溶血性贫血是系统性红斑狼疮的最初和唯一表现:病例报告
Pub Date : 2023-12-15 DOI: 10.9734/ijtdh/2023/v44i231501
U. P. Ikejiaku, Ogechi Patience Ezerioha, C. A. Nwaoha, Ngozi Lina Ekeigwe, Njideka Osuagwu
Autoimmune haemolytic anaemia (AIHA) is an acquired disorder resulting in the presence of antibodies against red blood cell antigens which leads to intravascular haemolysis. It can occur as the initial and sometimes the only presenting feature of Systemic Lupus Erythematosus (SLE). In this report, we describe the diagnostic evaluation and ongoing management of a 13-year-old female with AIHA as the first clinical feature of SLE. She presented with paleness of the body and yellowish discoloration of the eyes. Initial examination showed severe pallor with moderate jaundice. Investigations revealed severe anaemia with slightly elevated reticulocyte count and  positive direct coombs test(DCT).  Peripheral blood film showed microcytic, hypochromic anaemia. Bone marrow aspiration showed a hypocellular marrow for the age of the child. Immunological screening results were positive for antinuclear antibody (ANA) and anti-double stranded DNA (Anti-ds DNA). Patient is currently on Prednisolone, hydroxychloroquine and mycophenolate mofetil(MMF). The diagnosis of SLE with AIHA requires a good history, physical examination, high index of suspicion and extensive investigations. Management entails multidisciplinary approach, supportive care, initiation of treatment with steroids and  immunosuppressive drugs if necessary to minimize morbidity and mortality.
自身免疫性溶血性贫血(AIHA)是一种后天性疾病,患者体内存在针对红细胞抗原的抗体,从而导致血管内溶血。它可以作为系统性红斑狼疮(SLE)的首发症状,有时甚至是唯一的表现特征。在本报告中,我们描述了对一名以 AIHA 为系统性红斑狼疮首发临床特征的 13 岁女性患者的诊断评估和持续治疗。她出现身体苍白、眼睛变黄的症状。初步检查显示她面色苍白,伴有中度黄疸。检查结果显示严重贫血,网织红细胞计数略有升高,直接凝血试验(DCT)呈阳性。 外周血片显示小红细胞、低色素性贫血。骨髓穿刺显示,与患儿的年龄相符,骨髓细胞减少。免疫学筛查结果显示抗核抗体(ANA)和抗双链 DNA(Anti-ds DNA)呈阳性。患者目前正在服用泼尼松龙、羟氯喹和霉酚酸酯(MMF)。诊断系统性红斑狼疮合并 AIHA 需要良好的病史、体格检查、高度怀疑和广泛的检查。治疗需要采取多学科方法、支持性护理,必要时开始使用类固醇和免疫抑制剂,以尽量降低发病率和死亡率。
{"title":"Autoimmune Haemolytic Anaemia as Initial and Only Presentation of Systemic Lupus Erythematosus: A Case Report","authors":"U. P. Ikejiaku, Ogechi Patience Ezerioha, C. A. Nwaoha, Ngozi Lina Ekeigwe, Njideka Osuagwu","doi":"10.9734/ijtdh/2023/v44i231501","DOIUrl":"https://doi.org/10.9734/ijtdh/2023/v44i231501","url":null,"abstract":"Autoimmune haemolytic anaemia (AIHA) is an acquired disorder resulting in the presence of antibodies against red blood cell antigens which leads to intravascular haemolysis. It can occur as the initial and sometimes the only presenting feature of Systemic Lupus Erythematosus (SLE). In this report, we describe the diagnostic evaluation and ongoing management of a 13-year-old female with AIHA as the first clinical feature of SLE. She presented with paleness of the body and yellowish discoloration of the eyes. Initial examination showed severe pallor with moderate jaundice. Investigations revealed severe anaemia with slightly elevated reticulocyte count and  positive direct coombs test(DCT).  Peripheral blood film showed microcytic, hypochromic anaemia. Bone marrow aspiration showed a hypocellular marrow for the age of the child. Immunological screening results were positive for antinuclear antibody (ANA) and anti-double stranded DNA (Anti-ds DNA). Patient is currently on Prednisolone, hydroxychloroquine and mycophenolate mofetil(MMF). The diagnosis of SLE with AIHA requires a good history, physical examination, high index of suspicion and extensive investigations. Management entails multidisciplinary approach, supportive care, initiation of treatment with steroids and  immunosuppressive drugs if necessary to minimize morbidity and mortality.","PeriodicalId":126794,"journal":{"name":"International Journal of TROPICAL DISEASE &amp; Health","volume":"74 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138996212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-COVID-19 Clinical Symptom Frequency and Associated Factors in a Cohort of Patients Discharged from the ICU and Monitored for 12 Months, in Libreville, Gabon 加蓬利伯维尔一组从重症监护室出院并接受 12 个月监测的患者在 COVID-19 后的临床症状频率及相关因素
Pub Date : 2023-12-09 DOI: 10.9734/ijtdh/2023/v44i231500
Manomba Boulingui Charleine, Moutombi Ditombi Bridy, Ngomas Moussadji Jean Félix, Essomeyo Mebale Magalie, Ntsame Owono Michelle Marion, Kombila Ulrich Davy, Kouna-Ndouongo Philomène, Bouyou Akotet Marielle
Aims: This study determined the prevalence and evolution of long COVID symptoms in patients hospitalized for severe COVID-19 at the CHUL intensive care unit in Libreville, Gabon. Study Design: Prospective, longitudinal, study. Place and Duration of Study: Infectiology Unit, Centre Hospitalier Universitaire de Libreville Hospitalier Universitaire de LibrevH (CHUL), between January 2021 and January 2022. Methodology: We included 144 patients (84 men, 60 women; median age 46.4 [16-88] years) hospitalized in the intense care unit for a RT-PCR- confirmed COVID-19 and who have accepted a one-year follow-up. All patients were consulted quarterly for 12 months. During the follow-up, existence, appearance and types of symptoms were sought at 3, 6 and 12-months post-hospitalization. Results: The prevalence of long COVID-19 was 52.1% (n=75/144). Fatigue (21.3%), cough (20.8%), sleep disorders (16.0%) and anxiety (11.1%) predominated at month-3. The main symptoms reported 6-months after the onset of infection were dyspnea (9.7%; n=14), anxiety (7.6%; n=11), fatigue (6.2%; n=9) and cough (3.5%; n=5). One year after, the persistent symptoms were anxiety (6.5%; n=9), dyspnea (1.4%; n=2). Most participants had only one symptom: 60% at month-3, 79.5% at month-6 and 77.8% at 12-months (p=0.04). Conclusion: The long COVID is frequent among patients hospitalized for severe form of SARS-COV-2 infection. It is imperative to continue generating information for appropriate prevention and monitoring measures to be adopted in Gabon.
目的:本研究确定了加蓬利伯维尔CHUL重症监护病房重症COVID-19住院患者的长期COVID-19症状的患病率和演变。研究设计:前瞻性、纵向研究。学习地点和时间:2021年1月至2022年1月,利伯维尔大学医院中心(CHUL)感染科。方法:纳入144例患者(男性84例,女性60例;中位年龄46.4[16-88]岁),因RT-PCR确诊的COVID-19而在重症监护病房住院,并接受了一年的随访。所有患者在12个月内每季度进行一次咨询。随访期间,分别于住院后3、6、12个月随访患者症状的存在、表现及类型。结果:长型COVID-19患病率为52.1% (n=75/144)。疲劳(21.3%)、咳嗽(20.8%)、睡眠障碍(16.0%)和焦虑(11.1%)是第3个月患者的主要症状。感染6个月后报告的主要症状为呼吸困难(9.7%;N =14),焦虑(7.6%;N =11),疲劳(6.2%;N =9)和咳嗽(3.5%;n = 5)。一年后,持续症状为焦虑(6.5%;N =9),呼吸困难(1.4%;n = 2)。大多数参与者只有一种症状:3个月时为60%,6个月时为79.5%,12个月时为77.8% (p=0.04)。结论:在SARS-COV-2重症感染住院患者中,长冠状病毒多见。必须继续为将在加蓬采取的适当预防和监测措施提供资料。
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引用次数: 0
Effect of Azadirachta indica Leaf Extract on Some Biochemical Parameters in Wistar Albino Mice Infected with Plasmodium berghei 杜鹃叶提取物对感染疟原虫的 Wistar 白化小鼠某些生化参数的影响
Pub Date : 2023-12-02 DOI: 10.9734/ijtdh/2023/v44i221498
F. O. Idama, A. Onochie, M. E. Onuegbu, R. O. Anyanwu, E. C. Moneme
The use of medicinal plants in combating many tropical diseases including malaria is gaining wide acceptance owing to their many bioactive compounds. Malaria, which is caused by a Plasmodium parasite, and transmitted by the bite of infected mosquitoes is endemic in developing countries especially in Africa where it pose serious health challenge to the populace. This study evaluates the effect of Azadirachta indica leaf extract on some biochemical parameters in Wistar Albino mice infected with Plasmodiumberghei. A total of ninety (90) mature male swiss albino mice (free from infection and weighing between 25-35g) were used for the study. The animals were grouped into six classes (A-F) of fifteen (15) mice per group, per cage. Groups A to C served as the control groups [normal (uninfected plus distilled water), standard (infected plus Lonart (4mg/kg) and negative (infected plus distilled water)] respectively while groups D, E and F served as the treatment groups and were orally administered 100 mg/kg, 200 mg/kg and 400 mg/kg doses of leaf extract of Azadirachta indica for five (5) days consecutively. Malaria parasites (Plasmodium berghei, Anka strain) were inoculated using standard methods. At the end of the experimental periods, the animals were sacrificed and blood collected through cardiac puncture for bioassay studies. Activities of ALT, AST, ALP were determined using standard assay kits and concentrations of bilirubin (total and direct) as well as urea, creatinine, sodium, potassium, chloride and bicarbonate levels were carried out using standard methods. Results showed a significant increase (p<0.05) in serum activities of ALT and AST in extract treated animals when compared with the untreated control while there was significant decrease (p>0.05) in the serum activities of ALP in extract treated animals when compared with the untreated control. Results further showed an increase in the bilirubin (total and direct) levels of the extract treated groups as compared with the untreated control. Similar trends were observed for the levels of urea, creatinine, sodium, potassium and chloride. It could therefore be concluded that administration of Azadirachta indica leaf extract, though potent in fighting against malarial infection, could pose a threat to the liver and other organs of the body if not properly monitored.
利用药用植物防治包括疟疾在内的许多热带疾病正获得广泛接受,因为它们含有许多生物活性化合物。疟疾由疟原虫引起,通过受感染的蚊子叮咬传播,是发展中国家的地方病,特别是在非洲,它对民众的健康构成严重挑战。研究印楝叶提取物对感染乌姆伯格疟原虫的Wistar白化小鼠部分生化指标的影响。共有90只成年雄性瑞士白化病小鼠(未感染,体重在25-35g之间)被用于研究。动物被分为6类(A-F),每组15只(15)只,每个笼子。A ~ C组分别为对照组[正常组(未感染加蒸馏水)、标准组(感染加罗纳特(4mg/kg))和阴性组(感染加蒸馏水)],D、E、F组为治疗组,分别口服100、200、400 mg/kg剂量的印楝叶提取物,连续5 D。采用标准方法接种柏氏疟原虫,安卡菌株。实验结束时,处死大鼠,穿刺取血进行生物测定。采用标准试剂盒测定ALT、AST、ALP活性,采用标准方法测定总胆红素和直接胆红素浓度以及尿素、肌酐、钠、钾、氯化物和碳酸氢盐水平。结果表明,与未处理的对照组相比,处理过的动物血清ALP活性显著升高(p0.05)。结果进一步显示,与未处理的对照组相比,提取物处理组的胆红素(总和直接)水平有所增加。在尿素、肌酐、钠、钾和氯化物的水平上也观察到类似的趋势。因此,可以得出结论,印楝叶提取物虽然在对抗疟疾感染方面有效,但如果不加以适当监测,可能对肝脏和身体其他器官构成威胁。
{"title":"Effect of Azadirachta indica Leaf Extract on Some Biochemical Parameters in Wistar Albino Mice Infected with Plasmodium berghei","authors":"F. O. Idama, A. Onochie, M. E. Onuegbu, R. O. Anyanwu, E. C. Moneme","doi":"10.9734/ijtdh/2023/v44i221498","DOIUrl":"https://doi.org/10.9734/ijtdh/2023/v44i221498","url":null,"abstract":"The use of medicinal plants in combating many tropical diseases including malaria is gaining wide acceptance owing to their many bioactive compounds. Malaria, which is caused by a Plasmodium parasite, and transmitted by the bite of infected mosquitoes is endemic in developing countries especially in Africa where it pose serious health challenge to the populace. This study evaluates the effect of Azadirachta indica leaf extract on some biochemical parameters in Wistar Albino mice infected with Plasmodiumberghei. A total of ninety (90) mature male swiss albino mice (free from infection and weighing between 25-35g) were used for the study. The animals were grouped into six classes (A-F) of fifteen (15) mice per group, per cage. Groups A to C served as the control groups [normal (uninfected plus distilled water), standard (infected plus Lonart (4mg/kg) and negative (infected plus distilled water)] respectively while groups D, E and F served as the treatment groups and were orally administered 100 mg/kg, 200 mg/kg and 400 mg/kg doses of leaf extract of Azadirachta indica for five (5) days consecutively. Malaria parasites (Plasmodium berghei, Anka strain) were inoculated using standard methods. At the end of the experimental periods, the animals were sacrificed and blood collected through cardiac puncture for bioassay studies. Activities of ALT, AST, ALP were determined using standard assay kits and concentrations of bilirubin (total and direct) as well as urea, creatinine, sodium, potassium, chloride and bicarbonate levels were carried out using standard methods. Results showed a significant increase (p<0.05) in serum activities of ALT and AST in extract treated animals when compared with the untreated control while there was significant decrease (p>0.05) in the serum activities of ALP in extract treated animals when compared with the untreated control. Results further showed an increase in the bilirubin (total and direct) levels of the extract treated groups as compared with the untreated control. Similar trends were observed for the levels of urea, creatinine, sodium, potassium and chloride. It could therefore be concluded that administration of Azadirachta indica leaf extract, though potent in fighting against malarial infection, could pose a threat to the liver and other organs of the body if not properly monitored.","PeriodicalId":126794,"journal":{"name":"International Journal of TROPICAL DISEASE &amp; Health","volume":"41 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Associated with Febrile Treatment-Seeking Behaviour among Expectant Mothers in Ssekanyonyi, Uganda 与乌干达 Ssekanyonyi 地区准妈妈发热求医行为相关的因素
Pub Date : 2023-12-02 DOI: 10.9734/ijtdh/2023/v44i231499
Nanjobe Uniah, Christopher Ddamulira, Stephen S. Kizza, Lawlence Sserwanga, David Mutekanga
Background: Malaria fever is a serious health problem that contributes greatly to morbidity and mortality in Uganda. In Mityana District where 4 in 10 pregnancy deaths are malaria related mothers who do not seek treatment in health facilities when they experience febrile illnesses. Therefore, a study was undertaken to identify factors associated with treatment-seeking behavior among pregnant women suffering from febrile illnesses suspected to be malaria in Ssekanyonyi Sub-County in Mityana District, Uganda. Methods: A cross-sectional study in which questionnaires and key informant guides were administered to 198 expectant mothers to generate data on their socio-demographics and treatment seeking behaviour. SPSS software version 20.0 was used for data analysis and a Logistic Regression model was fitted to identify factors that independently influenced their health-seeking behavior. Results: Out of the198 expectant mothers enrolled in the study, 42.9% were aged 15-25 years, 73.7% had achieved Secondary education, and 46.5% were married. The treatment-seeking behavior was found to be standing at only 56.6%. Among the different factors studied, health education on malaria (AOR = 3.68, P = 0.000), the attitude of midwives (AOR = 1.45, P = 0.003), patient care (AOR = 0.33, P = 0.030), and attitude of the pregnant mother (AOR = 5.38, P = 0.000) were found to be statistically significantly associated with treatment-seeking behavior among pregnant mothers with febrile illnesses. Conclusion: The study concludes that health education on malaria, attitude of midwives and pregnant mothers are the most important in positively affecting treatment seeking behavior among pregnant mothers with febrile illnesses. Recommendations: Health education on malaria, attitude of midwives, patient care and attitude of pregnant mothers need to be given attention in a bid to reduce febrile illnesses. The Ministry of Health and other responsible stakeholders need to reinforce awareness programs on health education among women of reproductive age about the danger of febrile illnesses during pregnancy and also help midwives address issues related to their attitude towards pregnant mothers
背景:疟疾热是一个严重的健康问题,在乌干达造成很大的发病率和死亡率。在米提亚纳区,每10名怀孕死亡的母亲中就有4人与疟疾有关,她们在出现发热性疾病时没有到卫生机构寻求治疗。因此,在乌干达Mityana区的Ssekanyonyi县开展了一项研究,以确定与患有疑似疟疾的发热性疾病的孕妇寻求治疗行为相关的因素。方法:采用横断面研究方法,对198名准妈妈进行问卷调查和关键信息指南,以获得其社会人口统计学和求医行为的数据。采用SPSS 20.0软件进行数据分析,并拟合Logistic回归模型,确定独立影响其就医行为的因素。结果:198名参与研究的准妈妈中,42.9%的人年龄在15-25岁之间,73.7%的人受过中等教育,46.5%的人已婚。寻求治疗的行为仅占56.6%。其中,疟疾健康教育(AOR = 3.68, P = 0.000)、助产士态度(AOR = 1.45, P = 0.003)、患者护理(AOR = 0.33, P = 0.030)、孕妇态度(AOR = 5.38, P = 0.000)对发热性疾病孕妇就诊行为有显著影响。结论:疟疾健康教育、助产士和孕妇的态度是影响发热性疾病孕妇就医行为的最重要因素。建议:需要注意疟疾卫生教育、助产士的态度、病人护理和孕妇的态度,以减少发热性疾病。卫生部和其他负责任的利益攸关方需要加强育龄妇女关于怀孕期间发热性疾病危险的健康教育方案,并帮助助产士解决与她们对孕妇的态度有关的问题
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引用次数: 0
Effects of Using a Program of Student Role Model Development for Thai Children against COVID-19, Lower Primary School Level, A School in Khon Kaen Province, Thailand 泰国 Khon Kaen 省一所学校小学低年级学生针对 COVID-19 使用学生榜样培养计划的效果
Pub Date : 2023-12-02 DOI: 10.9734/ijtdh/2023/v44i221497
Thidaratana Lertwittayakul, L. Pholputta, Thawatchai Toemjai
Objective: This study aims to the effects of program of student role development for Thai children against COVID-19. Methods: A quasi-experimental study was conducted on 36 students in grades 1-3 in a lower primary school. The sample was selected using stratified random sampling to select 36 participants invited to a student role model development program for Thai children against COVID-19. The quantitative data were analyzed by descriptive statistics such as frequency, percentage, mean, and standard deviation. Statistics were compared using Paired t-test. Results: The majority of the respondents were female (69.4%). The results revealed that after the COVID-19 learning bases program, the respondents had a mean score of the knowledge level of Corona Virus and prevention of COVID-19 spread showed a low level (M=9.75, SD=1.66). The skill level in wearing, removing the mask was a moderate level (M=2.14, SD=0.56), hand washing was a low level (M=1.47, SD=0.45), and the characteristics of Thai children against COVID-19 was a moderate level (M=21.73, SD=1.56). The effects of the COVID-19 learning bases showed that after participation, the knowledge level of Corona Virus and prevention of COVID-19 spread, the skill level in wearing, removing the mask, hand washing, and the characteristics of Thai children against COVID-19 were higher than before participated with statistically significant (p-value<0.001). Conclusion: The student role model development program for Thai children against COVID-19 should be expanded to promote an attribute of Thai children against COVID-19 to extensive all classroom classes, and to promote good health for effective prevention of the coronavirus spread.
目的:本研究旨在探讨泰国儿童角色发展项目对新冠肺炎疫情的影响。方法:对某小学1-3年级36名学生进行准实验研究。样本采用分层随机抽样的方法选择,以选择36名被邀请参加泰国儿童抗COVID-19学生榜样发展项目的参与者。定量数据采用频率、百分比、均值、标准差等描述性统计方法进行分析。统计学比较采用配对t检验。结果:受访女性居多(69.4%)。结果显示,参与新冠肺炎学习基地项目后,被调查者对新冠病毒和新冠病毒传播预防知识水平的平均得分较低(M=9.75, SD=1.66)。泰国儿童佩戴、摘取口罩的技能水平为中等水平(M=2.14, SD=0.56),洗手水平为低水平(M=1.47, SD=0.45),对COVID-19的特征为中等水平(M=21.73, SD=1.56)。COVID-19学习基地的效果显示,参与后,泰国儿童对冠状病毒和COVID-19传播预防的知识水平、佩戴、摘口罩、洗手技能水平以及对COVID-19的特征均高于参与前,差异有统计学意义(p值<0.001)。结论:应扩大泰国儿童抗新冠肺炎学生榜样培养项目,将泰国儿童抗新冠肺炎的一项属性推广到所有课堂,促进健康,有效预防冠状病毒的传播。
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引用次数: 0
Determinants of Iron and Folic Acid Supplementation Adherence among Women of Reproductive Age in Kilifi South Sub-County, Kilifi County, Kenya 肯尼亚基利菲县基利菲南分县育龄妇女坚持补充铁和叶酸的决定因素
Pub Date : 2023-11-27 DOI: 10.9734/ijtdh/2023/v44i221496
Marion Bochaberi Machini, J. Oyore, Anthony Wanyoro
Background: Iron deficiency anemia among expectant women causes health consequences. Iron Folic Acid supplementation is the foremost strategy established to curb pregnancy-related anemia. Poor adherence is still a problem despite implementation. Pregnant women are recommended to take 60mgs of iron and 400 mcg of folic acid daily from conception till birth. Objective: The main objective of this study was to find out the determinants of iron and folic acid supplementation adherence among women of reproductive age, with children 0-23 months in Kilifi South Sub-County, Kilifi County, Kenya. Methodology: A cross-sectional survey was used. Cluster and simple random sampling were used to recruit study participants. Obtained sample size was 324 participants. chi-square and logistic regression were utilized to determine the degree of association between dependent and independent variables. Statistical significance was attained at P<0.05. Odds Ratio was used to test for the strength of association. Results: Adherence to iron and folic acid supplementation was low at 31.2%. Values for various variables were; education level of the mother (P=0.002), age(P=0.03, OR=1.26), monthly income (P=0.044, OR=1.622), Number of ANC visits(P=0.000), knowledge on IFAS (P=0.023), knowledge on anemia (P=0.005), knowledge of anemia causes (P=0.000), knowledge of effects of anemia in pregnancy (P=0.000), Being anemic during pregnancy (P=0.000; OR=3.35) IFAS accessibility (P= 0.019) and challenges faced when acquiring the supplements (P=0.03). Some of the challenges listed were late ANC attendance 57.1%, side effects 53.4%, forgetfulness 32.4%, long distance to the facility 59.4%, and stockouts 29.9%. Anemia was found to be high at 69.4%. Conclusions: Iron folic acid supplementation was low. Anemia prevalence was high. Individual factors associated with adherence were education level, antenatal visits, knowledge of the supplements, knowledge of anemia, knowledge of the effects of anemia, and being anemic. Health system factors associated with adherence were the availability of IFAS and experience of challenges during antenatal clinic visits.
背景:孕妇缺铁性贫血会影响健康。补充铁质叶酸是遏制孕期贫血的首要策略。尽管已经实施,但依从性差仍是一个问题。建议孕妇从受孕到分娩期间每天服用 60 毫克铁剂和 400 微克叶酸。 研究目的本研究的主要目的是找出肯尼亚基利菲县基利菲南分县育龄妇女和 0-23 个月婴儿坚持补充铁和叶酸的决定因素。 调查方法采用横断面调查。采用集群抽样和简单随机抽样的方法招募研究对象。利用卡方检验和逻辑回归来确定因变量和自变量之间的关联程度。统计显著性以 P<0.05 为限。采用比值比来检验关联的强度。 结果补充铁和叶酸的依从性较低,仅为 31.2%。各种变量的数值为:母亲的教育水平(P=0.002)、年龄(P=0.03,OR=1.26)、月收入(P=0.044,OR=1.622)、产前检查次数(P=0.000)、对 IFAS 的了解(P=0.023)、对贫血的了解(P=0.005)、对贫血原因的了解(P=0.000)、对孕期贫血影响的了解(P=0.000)、孕期贫血(P=0.000;OR=3.35)、IFAS 的可获得性(P= 0.019)以及获得补充剂时面临的挑战(P=0.03)。所列的一些挑战包括:产前检查迟到 57.1%、副作用 53.4%、健忘 32.4%、到医疗机构路途遥远 59.4%、缺货 29.9%。贫血率高达 69.4%。 结论叶酸铁的补充量较低。贫血患病率高。与坚持服用相关的个人因素包括教育水平、产前就诊、对补充剂的了解、对贫血的了解、对贫血影响的了解以及是否贫血。与坚持服药有关的卫生系统因素包括是否提供 IFAS 以及在产前检查中遇到的挑战。
{"title":"Determinants of Iron and Folic Acid Supplementation Adherence among Women of Reproductive Age in Kilifi South Sub-County, Kilifi County, Kenya","authors":"Marion Bochaberi Machini, J. Oyore, Anthony Wanyoro","doi":"10.9734/ijtdh/2023/v44i221496","DOIUrl":"https://doi.org/10.9734/ijtdh/2023/v44i221496","url":null,"abstract":"Background: Iron deficiency anemia among expectant women causes health consequences. Iron Folic Acid supplementation is the foremost strategy established to curb pregnancy-related anemia. Poor adherence is still a problem despite implementation. Pregnant women are recommended to take 60mgs of iron and 400 mcg of folic acid daily from conception till birth. Objective: The main objective of this study was to find out the determinants of iron and folic acid supplementation adherence among women of reproductive age, with children 0-23 months in Kilifi South Sub-County, Kilifi County, Kenya. Methodology: A cross-sectional survey was used. Cluster and simple random sampling were used to recruit study participants. Obtained sample size was 324 participants. chi-square and logistic regression were utilized to determine the degree of association between dependent and independent variables. Statistical significance was attained at P<0.05. Odds Ratio was used to test for the strength of association. Results: Adherence to iron and folic acid supplementation was low at 31.2%. Values for various variables were; education level of the mother (P=0.002), age(P=0.03, OR=1.26), monthly income (P=0.044, OR=1.622), Number of ANC visits(P=0.000), knowledge on IFAS (P=0.023), knowledge on anemia (P=0.005), knowledge of anemia causes (P=0.000), knowledge of effects of anemia in pregnancy (P=0.000), Being anemic during pregnancy (P=0.000; OR=3.35) IFAS accessibility (P= 0.019) and challenges faced when acquiring the supplements (P=0.03). Some of the challenges listed were late ANC attendance 57.1%, side effects 53.4%, forgetfulness 32.4%, long distance to the facility 59.4%, and stockouts 29.9%. Anemia was found to be high at 69.4%. Conclusions: Iron folic acid supplementation was low. Anemia prevalence was high. Individual factors associated with adherence were education level, antenatal visits, knowledge of the supplements, knowledge of anemia, knowledge of the effects of anemia, and being anemic. Health system factors associated with adherence were the availability of IFAS and experience of challenges during antenatal clinic visits.","PeriodicalId":126794,"journal":{"name":"International Journal of TROPICAL DISEASE &amp; Health","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139230620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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International Journal of TROPICAL DISEASE &amp; Health
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