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Understanding Host-Pathogen Interaction in the Cornea: Inflammatory Response and Cure 了解角膜中宿主与病原体的相互作用:炎症反应与治疗
Pub Date : 2024-06-02 DOI: 10.9734/ijtdh/2024/v45i61552
Suman Kumar, V. Munda, Neha Sharad, Rajan Kumar, Maneesh Kumar, Ratnesh Kumar, M. Jha, Shashank Nand Tiwari, Pratima Gupta
Microbial keratitis is a serious disease of the cornea that poses a major risk to the health and vision of people all over the world. It is caused by various microbial invaders, including bacteria, fungi and viruses, making it difficult to diagnose and treat. Combating microbial keratitis requires understanding the intricate web of immune responses and pathogenic pathways that cause the infection. To develop innovative strategies to treat the disease and improve patient survival, we need to understand how the immune system works, how hosts and infections interact and how complicated the pathophysiology is. Looking to the future, we are on the cusp of a transformative era in treating microbial keratitis. Innovations in therapeutic technology, such as targeted antimicrobial drugs, immunomodulatory therapies and precision medicine techniques, are set to revolutionise the field. These advancements will enable customised treatments for specific microbiological causes and patient characteristics. Integrating molecular biology, imaging and artificial intelligence into novel diagnostic techniques will enhance early diagnosis and personalised treatment programmes, leading to better clinical outcomes and reduced ocular morbidity. Collaboration between clinicians, researchers, and industry representatives is critical to accelerating the translation of scientific knowledge into clinical practice. Improving patient care, increasing treatment efficacy and saving eyesight are the goals for the future of microbial keratitis treatment.
微生物性角膜炎是一种严重的角膜疾病,对全世界人民的健康和视力构成重大威胁。它由细菌、真菌和病毒等各种微生物入侵引起,因此很难诊断和治疗。防治微生物性角膜炎需要了解导致感染的错综复杂的免疫反应和致病途径。要想制定治疗该疾病的创新策略并提高患者的存活率,我们需要了解免疫系统是如何工作的,宿主和感染是如何相互作用的,以及病理生理学是多么复杂。展望未来,我们正处在治疗微生物性角膜炎的变革时代的风口浪尖。治疗技术的创新,如靶向抗菌药物、免疫调节疗法和精准医疗技术,将彻底改变这一领域。这些进步将使针对特定微生物病因和患者特征的定制化治疗成为可能。将分子生物学、成像和人工智能整合到新型诊断技术中,将加强早期诊断和个性化治疗方案,从而提高临床疗效,降低眼部发病率。临床医生、研究人员和行业代表之间的合作对于加快将科学知识转化为临床实践至关重要。改善患者护理、提高疗效和挽救视力是未来微生物性角膜炎治疗的目标。
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引用次数: 0
COVID-19 Vaccine Hesitancy in a Rural Community of Nigeria COVID-19 尼日利亚农村社区对疫苗的犹豫态度
Pub Date : 2024-05-21 DOI: 10.9734/ijtdh/2024/v45i61550
Abebe E. Stephen, Obaseki I. Flourish, Dongo E. Naomi, Idialu. O. Perpetual, Uhomoibhi O. David, Omokaro J. Endurance, Ehizuelen G. Ehis, Osejele I. Meshach, Uangbaoje A. Cyril, Ugwoke O. Albert, Okpu U. Jeremiah, Ighodaro T. Osazuwa, Ogedegbe S. Idemudia, Jerhovwen Joshua, Okolo C. Caleb, Akhaine J. Precious
Introduction: Vaccine hesitancy is a major challenge to public health, particularly in the context of the COVID-19 pandemic. This research was aimed at examining COVID-19 vaccine hesitancy in the Idumebo Community, Irrua, Edo State, Nigeria, to understand the factors influencing vaccine acceptance and refusal. Objective: The primary objective of this research was to determine the level of knowledge, uptake, and reasons for vaccine hesitancy among residents of Idumebo, Irrua Edo State. By exploring these factors, the study aimed to provide insights that can inform targeted interventions to improve vaccine acceptance rates in the community. Method: A descriptive cross-sectional study was done among residents of age 18-60 years in Idumebo, utilizing structured questionnaires to gather data on socio-demographic characteristics, knowledge of COVID-19, and attitudes towards vaccination. Ethical considerations were prioritized, with institutional and community consent obtained before data collection. Results: The findings showed a high degree of awareness of COVID-19 among participants, with a majority acknowledging the contagious nature of the disease. However, vaccine hesitancy was observed among a subset of respondents, with reasons ranging from concerns about safety and efficacy to misinformation and mistrust. These results underscore the need for targeted educational campaigns and community engagement to address vaccine hesitancy effectively. Conclusion: It was concluded that the study brought to light the complex dynamics of COVID-19 vaccine hesitancy in the Idumebo Community, revealing the necessity of tailored interventions to address barriers to vaccine acceptance. By fostering a better understanding of community attitudes and concerns, public health authorities can develop strategies to enhance vaccine uptake and combat the spread of COVID-19 in the region.
导言:疫苗犹豫不决是公共卫生面临的一大挑战,尤其是在 COVID-19 大流行的情况下。本研究旨在调查尼日利亚埃多州伊尔鲁阿市伊杜梅博社区对 COVID-19 疫苗犹豫不决的情况,以了解影响接受和拒绝接受疫苗的因素。目标:本研究的主要目的是确定埃多州伊尔鲁阿市 Idumebo 社区居民对疫苗的了解程度、接种情况以及犹豫不决的原因。通过探究这些因素,本研究旨在提供有针对性的干预措施,以提高该社区的疫苗接受率。研究方法对 Idumebo 地区 18-60 岁的居民进行了描述性横断面研究,利用结构化问卷收集有关社会人口特征、COVID-19 知识和对疫苗接种态度的数据。研究优先考虑了伦理因素,并在收集数据前征得了机构和社区的同意。结果调查结果显示,参与者对 COVID-19 的认知度较高,大多数人承认该疾病具有传染性。但也有一部分受访者对疫苗犹豫不决,原因包括对安全性和有效性的担忧、信息错误和不信任。这些结果表明,有必要开展有针对性的教育活动和社区参与,以有效解决疫苗犹豫不决的问题。结论:这项研究揭示了伊杜梅博社区对 COVID-19 疫苗犹豫不决的复杂动态,揭示了有必要采取有针对性的干预措施来解决疫苗接受障碍。通过更好地了解社区的态度和关注点,公共卫生部门可以制定战略,提高疫苗的接种率,遏制 COVID-19 在该地区的传播。
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引用次数: 0
Prevalence, Associated Factors and Treatment Outcomes of Laboratory-confirmed Pregnancy Malaria at Antenatal Care in Three Healthcare Facilities of Douala, Cameroon 喀麦隆杜阿拉三家医疗机构产前检查中经实验室确诊的妊娠期疟疾患病率、相关因素和治疗结果
Pub Date : 2024-04-23 DOI: 10.9734/ijtdh/2024/v45i61543
T. Kuete, Henri Essome, Larissa Boukam Moche, Nadège Anabianina, Christiane Keddy Mangamba, A. Ekobo
Pregnancy malaria is a life-threatening condition to the mother, the fetus and the newborn. Since the implementation of the World Health Organization’s recommendations of specific malaria control strategies to pregnant women in malaria endemic countries, evaluation studies are needed to assess the prevalence of malaria in pregnancy. This cross-sectional prospective study was therefore set to determine the prevalence and associated factors as well as the treatment outcomes of Plasmodium infection among pregnant women attending antenatal care in three hospitals of Douala in Cameroon. Each volunteered pregnant woman received for antenatal care was questioned according to the study questionnaire to collect sociodemographic data, use of malaria prevention tools and pregnancy history. Then a laboratory test was carried for Plasmodium detection in the peripheral blood using microscopy and a HRP2-based rapid diagnostic test. Plasmodium carrying pregnant women were treated according to the national malaria program scheme followed by post-treatment follow-up. Data were processed and analyzed using SPSS.20 software. Association of Plasmodium infection with risk factors was analyzed as univariate using Pearson Chi-square and Fisher Exact tests considering a P-value < 0.05 as statistically significant. A total of 487 pregnant women aged between 18 years and 42 years were included in the study. The prevalence of Plasmodium infection was 3.5% and 4.3% by malaria rapid diagnostic test and microscopy respectively. Only Plasmodium falciparum asexual stage was detected. Parasite loads were low.  Factors associated with Plasmodium falciparum higher prevalence were being less than 21 years old (0.02), not sleeping under mosquitoe net daily (p=0.04) and having fever during the pregnancy (p=0.04). Parenteral treatment with either artesunate, artemether or quinine sulfate showed good efficacy. Conclusion: Pregnant women attending the antenatal cares harbored low Plasmodium infection prevalence and loads. Being of young age, not sleeping under mosquitoe bednet daily and having fever during the pregnancy were predictive Plasmodium falciparum. Plasmodium infected pregnant women were successfully treated with antimalarial medications recommended by the national Ministry of Public Health. The authors recommend increasing efforts by health authorities to strengthen malaria prevention in pregnant women through more adherence to sleeping under ITNs daily and taking IPT-sp as well as systematic detection of Plasmodium infection at each antenatal visit.
妊娠期疟疾对母亲、胎儿和新生儿都有生命危险。自世界卫生组织建议疟疾流行国家对孕妇实施特定的疟疾控制策略以来,需要开展评估研究来评估妊娠期疟疾的流行情况。因此,这项横断面前瞻性研究旨在确定在喀麦隆杜阿拉三家医院接受产前检查的孕妇中疟原虫感染的流行率、相关因素以及治疗效果。根据研究问卷对每位自愿接受产前检查的孕妇进行询问,以收集社会人口学数据、疟疾预防工具的使用情况和妊娠史。然后,使用显微镜和基于 HRP2 的快速诊断检测对外周血中的疟原虫进行实验室检测。携带疟原虫的孕妇根据国家疟疾计划接受治疗,并在治疗后进行随访。数据使用 SPSS.20 软件进行处理和分析。疟原虫感染与风险因素的关系采用 Pearson Chi-square 和 Fisher Exact 检验进行单变量分析,认为 P 值小于 0.05 为具有统计学意义。研究共纳入了 487 名年龄在 18 岁至 42 岁之间的孕妇。通过疟疾快速诊断检测和显微镜检查,疟原虫感染率分别为 3.5%和 4.3%。只检测到恶性疟原虫的无性阶段。寄生虫量较低。 与恶性疟原虫感染率较高相关的因素有:年龄小于 21 岁(0.02)、没有每天睡在蚊帐里(P=0.04)和怀孕期间发烧(P=0.04)。使用青蒿琥酯、蒿甲醚或硫酸奎宁进行肠外治疗显示出良好的疗效。结论接受产前保健的孕妇疟原虫感染率和感染量都很低。孕妇年龄小、没有每天睡在蚊帐里以及在怀孕期间发烧都是感染恶性疟原虫的诱因。感染了疟原虫的孕妇成功地接受了国家公共卫生部推荐的抗疟药物治疗。作者建议卫生当局加大力度,加强孕妇的疟疾预防工作,更严格地遵守每日在驱虫蚊帐内睡觉和服用 IPT-sp,并在每次产前检查时系统检测疟原虫感染情况。
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引用次数: 0
Epidemiology of Antimicrobial Resistance and the Wash Project: Averting a Potential Public Health Crisis in Nigeria Using the United Kingdom as a Case Study 抗菌药耐药性流行病学与洗涤项目:以英国为例,避免尼日利亚潜在的公共卫生危机
Pub Date : 2024-04-17 DOI: 10.9734/ijtdh/2024/v45i61542
Nnenna Victoria Ezugwu, Alicia Gayle, Chris Anyamene
Aim: To assess the impact of WASH services in mitigating the proliferation of AMR in Nigeria, with the United Kingdom serving as a reference population.Study Design: This is a review article.Duration of Study: An extensive review was conducted in relevant databases, specifically focusing on research studies published in peer-reviewed journals in English. These studies were conducted in both the United Kingdom and Nigeria, with the primary objective of investigating the relationship between Water, Sanitation, and Hygiene practices and Antimicrobial Resistance. The search spanned from May 2015, coinciding with the adoption of the global action on antimicrobial resistance by the World Health Assembly, to July 2023. The literature search was completed on August 10, 2023.Methodology: The search involved electronic databases such as EBSCO, PubMed, Science Direct, and CINAHL Complete. Additionally, relevant literature was searched on the websites of organizations such as the World Health Organization, Nigeria Centre for Disease Control and Prevention, and the Centre for Disease Control and Prevention, Public Health England. The quality of the papers was evaluated using CASP tools to determine their reproducibility, credibility, dependability, and confirmability. Out of the initial 705 articles that were drawn from the different databases, 12 studies were included in the literature review.Results: The review of the various literature showed that WASH interventions in Nigeria are geared toward disease transmission/infection prevention and control and not the combatting of AMR while studies in the UK have shown positive advances in tackling AMR utilizing WASH services.Conclusion: Promoting the development and provision of WASH infrastructure in diverse Nigerian settings is crucial for addressing antimicrobial resistance (AMR). This literature review serves as a call to action for stakeholders at the national, regional, and local levels in Nigeria, emphasizing the necessity of nationwide investment in WASH infrastructure, the development of policies that support the implementation of WASH in all the communities and villages, extensive health promotion campaigns to raise awareness about AMR, and community-level interventions to contain the spread of AMR in Nigeria.
目的:以英国为参照人群,评估讲卫生服务对缓解尼日利亚AMR扩散的影响:这是一篇综述文章:研究时间:在相关数据库中进行了广泛的审查,特别关注在同行评审期刊上发表的英文研究报告。这些研究在英国和尼日利亚进行,主要目的是调查水、环境卫生和个人卫生习惯与抗菌素耐药性之间的关系。搜索时间跨度为 2015 年 5 月至 2023 年 7 月,与世界卫生大会通过抗菌素耐药性全球行动的时间相吻合。文献检索于 2023 年 8 月 10 日完成:检索涉及 EBSCO、PubMed、Science Direct 和 CINAHL Complete 等电子数据库。此外,还在世界卫生组织、尼日利亚疾病控制和预防中心以及英格兰公共卫生疾病控制和预防中心等组织的网站上搜索了相关文献。使用 CASP 工具对论文质量进行了评估,以确定其可重复性、可信度、可靠性和可确认性。在从不同数据库中提取的最初 705 篇文章中,有 12 项研究被纳入文献综述:对各种文献的综述显示,尼日利亚的讲卫生运动干预措施主要针对疾病传播/感染预防和控制,而非抗击AMR,而英国的研究则表明,在利用讲卫生运动服务抗击AMR方面取得了积极进展:结论:在尼日利亚的各种环境中促进讲卫生运动基础设施的发展和提供对于解决抗菌素耐药性(AMR)问题至关重要。本文献综述呼吁尼日利亚国家、地区和地方各级利益相关者采取行动,强调有必要在全国范围内投资于讲卫生运动基础设施,制定支持在所有社区和村庄实施讲卫生运动的政策,广泛开展健康宣传活动以提高人们对 AMR 的认识,并在社区一级采取干预措施以遏制 AMR 在尼日利亚的蔓延。
{"title":"Epidemiology of Antimicrobial Resistance and the Wash Project: Averting a Potential Public Health Crisis in Nigeria Using the United Kingdom as a Case Study","authors":"Nnenna Victoria Ezugwu, Alicia Gayle, Chris Anyamene","doi":"10.9734/ijtdh/2024/v45i61542","DOIUrl":"https://doi.org/10.9734/ijtdh/2024/v45i61542","url":null,"abstract":"Aim: To assess the impact of WASH services in mitigating the proliferation of AMR in Nigeria, with the United Kingdom serving as a reference population.\u0000Study Design: This is a review article.\u0000Duration of Study: An extensive review was conducted in relevant databases, specifically focusing on research studies published in peer-reviewed journals in English. These studies were conducted in both the United Kingdom and Nigeria, with the primary objective of investigating the relationship between Water, Sanitation, and Hygiene practices and Antimicrobial Resistance. The search spanned from May 2015, coinciding with the adoption of the global action on antimicrobial resistance by the World Health Assembly, to July 2023. The literature search was completed on August 10, 2023.\u0000Methodology: The search involved electronic databases such as EBSCO, PubMed, Science Direct, and CINAHL Complete. Additionally, relevant literature was searched on the websites of organizations such as the World Health Organization, Nigeria Centre for Disease Control and Prevention, and the Centre for Disease Control and Prevention, Public Health England. The quality of the papers was evaluated using CASP tools to determine their reproducibility, credibility, dependability, and confirmability. Out of the initial 705 articles that were drawn from the different databases, 12 studies were included in the literature review.\u0000Results: The review of the various literature showed that WASH interventions in Nigeria are geared toward disease transmission/infection prevention and control and not the combatting of AMR while studies in the UK have shown positive advances in tackling AMR utilizing WASH services.\u0000Conclusion: Promoting the development and provision of WASH infrastructure in diverse Nigerian settings is crucial for addressing antimicrobial resistance (AMR). This literature review serves as a call to action for stakeholders at the national, regional, and local levels in Nigeria, emphasizing the necessity of nationwide investment in WASH infrastructure, the development of policies that support the implementation of WASH in all the communities and villages, extensive health promotion campaigns to raise awareness about AMR, and community-level interventions to contain the spread of AMR in Nigeria.","PeriodicalId":126794,"journal":{"name":"International Journal of TROPICAL DISEASE &amp; Health","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Malnutrition and Associated Factors among HIV Seropositive Adults on Antiretroviral Therapy at the Regional Hospital, Buea, Cameroon 喀麦隆布埃亚地区医院接受抗逆转录病毒疗法的艾滋病毒血清反应阳性成人的营养不良患病率及相关因素
Pub Date : 2024-04-15 DOI: 10.9734/ijtdh/2024/v45i61540
Bombey Mary-Flavie Nkanjo, Tendongfor Nicholas, E. Ojong
Introduction: Malnutrition refers to deficiencies, excesses, or imbalances in a person’s intake of energy and/or nutrients and HIV which infects CD4 cells causes immune suppression which can further be worsened by poor nutrition. More than 37.7 million people are living with HIV in the world out of which about 36 million are adults.Aims: The study aimed to determine the prevalence of malnutrition and associated factors among human immunodeficiency virus (HIV) seropositive adults on antiretroviral therapy at the HIV care and treatment center of the Buea Regional hospital, Cameroon.Study Design: A Hospital-based Cross sectional study design.Place and duration of study: Buea regional hospital at the HIV care and treatment centre, South West Region of Cameroon between April 2022 to June 2022.Materials and method:  We included 139 HIV seropositive individuals (17 men, 177 women age range 26 to 59 years). Nutritional status was assessed using anthropometric and clinical methods. A 24-hour dietary diversity was assessed using a questionnaire. Data was analyzed using SPSS version 25.0.Results: The prevalence of underweight, overweight and obesity among the participants were 1.4 %, 38.8%, and 24.4% respectively. In the bivariate analysis, sex of the participants (χ2 = 4.715, p = 0.030) and attendance to HIV-related counseling sessions (χ2 = 4.512, p = 0.034) were significantly associated with malnutrition. The mean dietary diversity score of the study respondents was 4.97±1.6 with only 37% of the respondents achieving a minimum dietary diversity. In the multivariate logistic regression analysis, the odds of those who received HIV-related counselling being malnourished(overweight) was 3.29 times more than those who did not receive HIV-related counselling (AOR=3.29, p=0.036).  Conclusions: There is a high burden of overweight and obesity in the HIV population of the Regional Hospital Buea. The only factor independently associated to malnutrition(overweight) was uptake of nutrition related counselling. Majority of the HIV seropositive patients in the Regional Hospital Buea had a poor dietary diversity. Nutritional counseling should be an important part of persons living with HIV/AIDS (PLWHA) routine follow-up.
导言:营养不良是指一个人摄入的能量和/或营养素不足、过量或失衡,而感染 CD4 细胞的艾滋病毒会导致免疫抑制,营养不良会进一步加剧免疫抑制。研究目的:本研究旨在确定喀麦隆布埃亚大区医院艾滋病护理和治疗中心接受抗逆转录病毒治疗的人类免疫缺陷病毒(HIV)血清阳性成人中营养不良的发生率及相关因素:医院横断面研究:研究地点和时间:喀麦隆西南大区布埃亚大区医院艾滋病护理和治疗中心,2022 年 4 月至 2022 年 6 月: 我们纳入了 139 名艾滋病毒血清反应呈阳性者(17 名男性,177 名女性,年龄在 26 岁至 59 岁之间)。营养状况通过人体测量和临床方法进行评估。使用问卷对 24 小时饮食多样性进行了评估。数据使用 SPSS 25.0 版进行分析:参与者中体重不足、超重和肥胖的比例分别为 1.4%、38.8% 和 24.4%。在双变量分析中,参与者的性别(χ2 = 4.715,P = 0.030)和参加艾滋病相关咨询会议的次数(χ2 = 4.512,P = 0.034)与营养不良有显著相关性。研究对象的平均膳食多样性得分为 4.97±1.6,只有 37% 的研究对象达到了最低膳食多样性水平。在多变量逻辑回归分析中,接受艾滋病相关咨询者营养不良(超重)的几率是未接受艾滋病相关咨询者的 3.29 倍(AOR=3.29,P=0.036)。 结论在布埃亚地区医院的艾滋病感染者中,超重和肥胖的比例很高。唯一与营养不良(超重)独立相关的因素是接受了营养相关咨询。布埃亚地区医院的大多数艾滋病毒血清反应呈阳性的患者饮食多样性较差。营养咨询应成为艾滋病毒/艾滋病感染者(PLWHA)常规随访的重要组成部分。
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引用次数: 0
Analyzing the Flint Water Crisis: Insights and Suggestions for Future Resilience 分析弗林特水危机:对未来复原力的见解和建议
Pub Date : 2024-04-15 DOI: 10.9734/ijtdh/2024/v45i61541
O. Ekwebene, Ijeoma Chukwu Amaechi, Ipinoluwa Akintola, Ezera Emetu
The “Type of Article” of this paper is “Letter to the Editor”. This paper discuses about: “Analyzing the Flint Water Crisis: Insights and Suggestions for Future Resilience”. No formal abstract is available. Readers are requested to read the full article.
本文的 "文章类型 "为 "致编辑的信"。本文讨论的是"分析弗林特水危机:对未来复原力的启示和建议"。本文没有正式摘要。请读者阅读全文。
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引用次数: 0
Family Factors Influencing Intentional Self-organophosphate Poisoning Among Persons of Age 15-30 Years in Kericho County, Kenya 影响肯尼亚凯里乔县 15-30 岁人群故意自身有机磷中毒的家庭因素
Pub Date : 2024-04-11 DOI: 10.9734/ijtdh/2024/v45i61538
L. K. Sigey
Aim: The aim of this study was to explore factors that influence intentional self-poisoning among patients aged 15-30 years in Kericho County. The study's specific goals were to explore the influence of family factors, on intentional self-organophosphate poisoning.Study Design: The study adopted cross-sectional study design.Place and Duration of Study: Study was conducted in Kericho County, health facilities for a period of 4 months.Methodology: 100 respondents were included in the study (88 males and 12 females).Sample size of 100 respondents was used which was estimated population of patients who might have been affected with poisoning during study period. Data was collected from respondents who were attended and recovered during the study period of four months.Data Analysis: The collected quantitative data was analyzed using Statistical Package for Social Sciences (SPSS) version 21. Correlation and regression analysis were carried out to establish relationship between categorical variables. The analyzed data were presented in tables, charts and the corresponding thematic areas. Statistical significance was set at p<0.05.Result: The results indicated that family factors showed positive influenced on self-poisoning. had correlation of 13.319 where significance was set at p=0.0001 indicating a high likelihood of influencing one to self-poison. Conclusion: This study suggested counselors to have  a prediction model to classify patients at a higher risk of self-harm by use of poisons and to focus on individual preventive strategies. Patients in the high-risk group require referral for mental health assessment and counseling both individual and family to alleviate helplessness and hopelessness, healthy lifestyle like come together party, and restriction of access to poison .This will eventually reduce these cases of self-poisoning in our Counties and Country at large.
研究目的:本研究旨在探讨影响凯里乔县 15-30 岁患者故意自我中毒的因素。研究的具体目标是探讨家庭因素对故意自身有机磷中毒的影响:研究采用横断面研究设计:研究地点和时间:研究在凯里乔县的医疗机构进行,为期 4 个月。研究方法:研究对象为 100 名受访者(88 名男性和 12 名女性),样本量为 100 名受访者,这是在研究期间可能受到中毒影响的患者的估计人数。数据分析:收集到的定量数据使用 21 版社会科学统计软件包(SPSS)进行分析。对分类变量之间的关系进行了相关分析和回归分析。分析数据以表格、图表和相应的专题领域的形式呈现。统计显著性设定为 p<0.05:结果表明,家庭因素对自毒有积极影响,相关系数为 13.319,显著性为 p=0.0001,表明家庭因素很有可能影响一个人的自毒行为。结论本研究建议心理咨询师建立一个预测模型,对使用毒药自残的高危患者进行分类,并重点关注个人预防策略。高危人群中的患者需要转诊接受心理健康评估,并接受个人和家庭咨询,以缓解无助和绝望情绪,养成健康的生活方式(如聚会),并限制获取毒药的途径。 这将最终减少本县乃至全国的自毒案例。
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引用次数: 0
Study of Person-specifc Life Events Influencing Intentional Self-harm in Young Population in Kericho County, Kenya 影响肯尼亚凯里乔县年轻人故意自残的个人特定生活事件研究
Pub Date : 2024-04-11 DOI: 10.9734/ijtdh/2024/v45i61539
L. K. Sigey
Background: Suicide has been among the leading causes of death in 15-29-year-old people worldwide. Over three quarters (79%) of all suicides occur in lower and mid-level economic countries.Aim: The study's specific goal was to assess factors influencing personal specific life events on intentional self-organophosphate poisoning.Place and Duration of Study: Study was conducted in Kericho County, health facilities year 2023.Design: The study adopted cross-sectional study design and purposive sampling technique.Methodology: 100 respondents were included in the study(88 males and 12 females).Data Analysis: The collected quantitative data were analyzed using Statistical Package for Social Sciences (SPSS) version 21. Correlation and regression analysis was carried out to establish relationship between variables. Chi-square also was used to measure correlation of variables.The analyzed data were presented in tables, charts and the corresponding thematic areas. Statistical significance was set at p<0.05. Results: The results indicated that personal life specific perspective showed positive influenced on self-poisoning. The results indicated that personal specific perspectives/events had chi-square of 13.867 where significance was set at p=0.0001 indicating a high likelihood of influencing one to self-poison.Conclusion: Self-poisoning study offers important knowledge on one of the commonest  popular methods of self- suicidal attempts; that can guide on public health approaches to mitigate this phenomenon, and the lack of research on the influences of personality traits and self-poisoning is the main reason for this study.  These cases of self-poisoning influence by self-perfection may increase morbidity and mortality incidences and also overburdening family financially to meet cost of hospitalization.
背景:自杀一直是全球 15-29 岁人群的主要死因之一。超过四分之三(79%)的自杀发生在中低层经济国家。研究目的:本研究的具体目标是评估个人特定生活事件对故意自身有机磷中毒的影响因素:研究在凯里乔县的医疗机构进行,时间为 2023 年:研究采用横断面研究设计和目的性抽样技术。研究方法:100 名受访者(88 名男性和 12 名女性)参与研究:收集到的定量数据使用社会科学统计软件包(SPSS)第 21 版进行分析。进行了相关和回归分析,以确定变量之间的关系。分析数据以表格、图表和相应的专题领域的形式呈现。统计显著性设定为 p<0.05。结果结果表明,个人生活特定视角对自毒有积极影响。结果表明,个人特定视角/事件的卡方为 13.867,显著性设定为 p=0.0001,表明影响一个人自我中毒的可能性很高:自我投毒研究提供了关于一种最常见的自杀企图的重要知识,可以指导公共卫生方法来缓解这一现象,而缺乏关于人格特质和自我投毒影响因素的研究是本研究的主要原因。 这些受自我完善影响的自毒案例可能会增加发病率和死亡率,同时也会加重家庭的经济负担,以支付住院费用。
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引用次数: 0
Public Health Implications of Cholera- a Water Sanitation and Hygiene (WASH) Related Infectious Disease in the Era of Climate Change: The Nigeria Experience 气候变化时代与饮水、环卫和讲卫生运动(WASH)相关的霍乱传染病对公共卫生的影响:尼日利亚的经验
Pub Date : 2024-04-09 DOI: 10.9734/ijtdh/2024/v45i61537
Nnenna Ihua, Owhorchukwu Amadi-Wali, E. Onosakponome, Chidi L. C. Ndukwu, R. A. Ikpeama, C. U. Okorocha
Water, sanitation and hygiene (WASH) play key roles in management of infectious diseases like cholera and other waterborne diseases; given that millions of people globally have no access to safe water. This cross-sectional study, conducted in 7 communities of Ogoni region (Khana, Gokana, Tai and Eleme LGAs), Orashi region (Abua/Odual, Ahoada West, Ahoada East and Ogba-Egbema-Ndoni LGAs) and Obolo region (Andoni LGA) all in Rivers State, Nigeria, enrolled 274 inhabitants comprising 164 females and 110 males. These included persons passing watery stools accompanied with vomiting, abdominal cramps and those with such prehistory. Questionnaires were used to obtain socio-demographic data. A total of 274 faecal samples were collected and transported in Cary-Blair stool culture transport medium to Rivers State University Teaching Hospital laboratory; and inoculated on Thiosulphate sulphate citrate bile salt-sucrose agar. Gram staining and biochemical tests were performed using standard procedures. Among the 274 subjects, 40 were infected giving a prevalence rate of 14.6%, including 26(15.9%) females and 14(12.7%) males though this was statistically insignificant, (U=8738.000, p=0.474). On educational levels, those who attended secondary schools had the highest prevalence rate (26.3%), compared with others and it was statistically significant, (p=0.00). WASH perceived predisposing factor showed the prevalence rate among those without access to safe water was 33(21.6%) against those with access to safe water 7(5.8%) and was statistically significant, (p=0.00). Subjects engaged in routine environmental sanitation and hygiene practices had lower prevalence 7(7.6%) than their counterparts, 33(18.1%), p=0.02. Respondents who think climate change had a positive impact on cholera transmission had prevalence of 34(23.3%) against those who disagreed, 6(4.7%), which was statistically significant. The study deduced that unavailability of safe drinking water, climate change, and unhygienic practices were major predisposing factors to cholera infection. Provision of safe water is advocated as greater percentage of the communities lacked access to safe drinking water. Routine environmental sanitation exercise should be revisited and enforced.
鉴于全球有数百万人无法获得安全饮用水,水、环境卫生和个人卫生(WASH)在霍乱等传染病和其他水传播疾病的管理中发挥着关键作用。这项横断面研究在尼日利亚河流州的奥戈尼地区(Khana、Gokana、Tai 和 Eleme LGA)、奥拉西地区(Abua/Odual、Ahoada West、Ahoada East 和 Ogba-Egbema-Ndoni LGA)以及奥博洛地区(Andoni LGA)的 7 个社区进行,共招募了 274 名居民,其中包括 164 名女性和 110 名男性。这些人包括排出水样便并伴有呕吐、腹部绞痛的人以及有此类病史的人。调查问卷用于获取社会人口学数据。共收集了 274 份粪便样本,用 Cary-Blair 粪便培养运输培养基运送到河流州立大学教学医院实验室,并接种在硫代硫酸盐柠檬酸盐胆盐蔗糖琼脂上。采用标准程序进行了革兰氏染色和生化检验。在 274 名受试者中,有 40 人受到感染,感染率为 14.6%,其中女性 26 人(15.9%),男性 14 人(12.7%),但这一比例在统计学上并不显著(U=8738.000,P=0.474)。在受教育程度方面,与其他人群相比,上过中学的人群患病率最高(26.3%),且在统计学上有显著意义(P=0.00)。水、环境卫生和个人卫生感知的诱发因素显示,无法获得安全饮用水者的发病率为 33(21.6%),而获得安全饮用水者的发病率为 7(5.8%),且有统计学意义(P=0.00)。参与日常环境卫生和个人卫生活动的受访者中,7(7.6%)人的患病率低于 33(18.1%)人,P=0.02。认为气候变化对霍乱传播有积极影响的受访者为 34(23.3%)人,而不同意的受访者为 6(4.7%)人,差异具有统计学意义。研究推断,缺乏安全饮用水、气候变化和不卫生习惯是导致霍乱感染的主要因素。由于大部分社区缺乏安全饮用水,因此提倡提供安全饮用水。应重新审视和实施例行的环境卫生工作。
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引用次数: 0
Evaluation of Anti-urolithiasis Activity by Nucleation Assay 通过成核试验评估抗尿路结石活性
Pub Date : 2024-04-08 DOI: 10.9734/ijtdh/2024/v45i61535
Siddhartha Lolla, Harika Peddinti, Sravanthi Gojuvaka, Samrin Saba, Uma Devi Dasari, Madhavi Pillalamarri
Many causes, including the efficiency of plant medicines and their lower side effects when compared to contemporary medications, have contributed to the current rebirth of plant therapies. Given the current situation, basic scientific research on the therapeutic herbs utilized in indigenous systems is urgently needed. The purpose of this review is to provide information on current developments in the study of medicinal plants recognized for their antiurolithiatic properties. This could assist researchers in determining and creating suitable lead compounds or plant products that are advantageous in the treatment of urolithiasis. A series of physicochemical processes, including supersaturation, nucleation, growth, aggregation, and retention inside the kidneys, combine to form kidney stones. In developed nations, 10–12% of people suffer from urinary stones. There are very few places in the world where stone disease is uncommon, such as Germany and the coastal regions of Japan. Thus, the purpose of this review is to provide information about current developments in the study of medicinal plants recognized for their antiurolithiatic properties. Researchers may find this article useful in identifying the primary compounds or herbal products that exhibit urolithiatic activity.
许多原因,包括植物药的高效性及其与现代药物相比较低的副作用,促成了植物疗法的重生。鉴于目前的情况,迫切需要对本土系统中使用的治疗草药进行基础科学研究。本综述旨在提供有关公认具有抗尿失禁特性的药用植物研究的最新进展信息。这将有助于研究人员确定和创造对治疗尿路结石有利的合适先导化合物或植物产品。一系列物理化学过程,包括过饱和、成核、生长、聚集和在肾脏内的滞留,共同形成了肾结石。在发达国家,10%-12% 的人患有泌尿系结石。世界上只有极少数地方不常见结石病,如德国和日本沿海地区。因此,本综述旨在提供有关公认具有抗尿路结石特性的药用植物研究的最新进展信息。研究人员可能会发现这篇文章有助于确定具有抗尿路结石活性的主要化合物或草药产品。
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引用次数: 0
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