GSC Biological and Pharmaceutical Sciences最新文献

{"title":"Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®","authors":"Zaïnab Kajeiou, Issam Mokhtari, Loubna Yacoubi, Amina Himri, Dounia El Moujtahide, El houcine Sebbar, Mohammed Choukri","doi":"10.30574/gscbps.2024.26.2.0068","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0068","url":null,"abstract":"In the evolving landscape of clinical diagnostics, the significance of folate takes center stage as precision and innovation shape advancements in analytical methodologies. Folate, a pivotal element in cellular metabolism, governs physiological processes and serves as an indicator for various medical conditions. This study employs the Chemiluminescent Microparticle Immunoassay (CMIA), known for its accuracy, to assess the reproducibility and repeatability of serum folate levels. Folate's role in cellular metabolism influences diverse physiological functions, making its precise quantification crucial for identifying and monitoring conditions such as folate deficiency. The CMIA method emerges as a robust approach, leveraging immunological specificity for high precision and reliability. Utilizing the Abbott Alinity ci® Analyzer, a technologically advanced clinical chemistry instrument, this study incorporates a systematic analytical method verification procedure. This involves quantification through a standardized protocol and a comparative analysis against criteria set by esteemed societies (RICOS and FSCB), ensuring comprehensive insights into analysis techniques. The reproducibility test, evaluating the impact of various factors on assay results, reveals low Coefficient of Variation (CV) values (CV1: 10.25%, CV2: 8.58%, CV3: 9.13%) across different levels. The results align with quality control limits, emphasizing the method's reliability. Repeatability assessment demonstrates exceptionally low CV values (CV1: 4.84%, CV2: 3.41%, CV3: 1.89%), highlighting the method's stability and precision under controlled conditions.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"45 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization and bioactivity of Anredera cordifolia (Ten.) Steenis","authors":"Marina Silalahi","doi":"10.30574/gscbps.2024.26.2.0020","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0020","url":null,"abstract":"Anredera cordifolia (Ten.) Steenis is a multifunctional plant have been used decoration, food and traditional medicine. This study aims to explain the botany and use of A. cordifolia as a traditional medicinal plant and its bioactivity. The method used in this study is library research online using the keywords such as: A. cordifolia, uses of A. cordifolia and bioactivity of A. cordifolia. The all of information are synthesized so that explain of botanicals, benefits and bioactivity. The A. cordifolia has activity as cure of wound, anti-bacterial, anti-cholesterol and obesity, postpartum, anti-diabetes mellitus, antioxidant and anti-inflammatory, anti-hypertensive, anti-cancer, and lowering uric acid. The A. cordifolia contains triterpenoid saponins, steroids, saponins, glycosides, flavonoids, saponins and alkaloids, ursolic acid, ancordin, and apigenin. Saponins have been used to treat diabetes, liver, hepatitis, cardiovascular hypertension, hyper-cholesterol, and physical stress. Utilization of A. cordifolia as an anti-microbial has the potential to be used as a food preservative as well as providing healthful effects.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140421725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of ethanol extract of dayak onion (Eleutherine palmifolia) on the number of Leydig cells and seminiferous tubules diameter in mice (Mus musculus) exposed to monosodium glutamate","authors":"Dara Dinanti, Sri Pantja Madyawati, Nove Hidajati, Dewa Ketut Meles, Rahmi Sugihartuti, Epy Muhammad Luqman","doi":"10.30574/gscbps.2024.26.2.0042","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0042","url":null,"abstract":"Objective: This study aimed to investigate the preventive effect of ethanol extract from dayak onion (Eleutherine palmifolia) on the number of Leydig cells and the diameter of seminiferous tubules in mice (Mus musculus) exposed to monosodium glutamate (MSG). Method: A total of 25 mice were divided into 5 groups. Group C- received only 0.5% CMC-Na. Group C+ was given 0.5% CMC-Na and 4 mg/gBW/day of MSG. Groups T1, T2, and T3 were administered dayak onion (Eleutherine palmifolia) ethanol extract at doses of 30, 60, and 120 mg/kgBW/day, respectively, along with 4 mg/gBW/day of MSG. All treatments were administered orally for 52 days. Result: The results indicated that MSG exposure resulted in a significant decrease in the number of Leydig cells and the diameter of seminiferous tubules in the C+ group compared to the C- group (p < 0.05). Administration of dayak onion (Eleutherine palmifolia) ethanol extract at doses of 30 (T1), 60 (T2), and 120 mg (T3) per kg BW showed similar results (p>0.05) to those of the C- group. Conclusion: In conclusion, the administration of dayak onion (Eleutherine palmifolia) ethanol extract mitigates the harmful effects of MSG on the number of Leydig cells and seminiferous tubules diameter in mice (Mus musculus) as a model. This research shows that Dayak onion (Eleutherine palmifolia) plays a role in reproductive health care.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"136 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of adiponectin with thyroid dysfunction in diabetes mellitus type II","authors":"Sabah Qusay Abd-Alhussain, Omar Sabbar Sallman","doi":"10.30574/gscbps.2024.26.2.0066","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0066","url":null,"abstract":"The two most prevalent endocrine-related conditions seen in clinical practice are thyroid diseases (TD) and diabetes mellitus (DM). Diabetes mellitus and thyroid dysfunction are strongly related conditions. Numerous research investigations have reported that individuals with diabetes mellitus are more likely to have thyroid issues, and vice versa. Compared to individuals without diabetes, Type 2 Diabetes Mellitus (T2DM) patients have higher rates of both hypothyroidism and hyperthyroidism. Thyroid hormones are circulating hormones that impact various organs and tissues, have a vital role in the metabolism of proteins, fats, and carbohydrates, and can exacerbate glycemic control in individuals with Type II Diabetes Mellitus (T2DM). At the Specialized Center for Endocrinology and Diabetes – Al-Kindi Teaching Hospital in Baghdad, a case-control research was carried out. The samples were gathered between January 1, 2021, and April 1, 2021. The current study had one hundred twenty (120) volunteers, all of whom fasted for eight to twelve hours before to the test: · Thirty (30) patients suffered from diabetic mellitus type II seventeen (17) females and thirteen (13) males. · Thirty (30) were control with, sixteen (16) females and fourteen (14) males. · Thirty (30) patients had thyroid dysfunction eighteen (18) females and twelve (12) males. · Thirty (30) patients had thyroid dysfunction and diabetes mellitus type II, sixteen (16) females and fourteen (14) males. Variables such as gender, age, Body Mass Index (BMI), thyroid hormones ,Fasting Blood Sugar (FBS), Glycated Hemoglobin (HbA1c), lipid profile (TG, CHOL, LDL-C, HDL-C, VLDL-C), Adiponectin (ADP)were measured and documented from participants included in this study. According to the results of hormones, there were substantial variations in all of the hormone levels. Thyroid Stimulating Hermon (TSH) was the highest level in Thyroid Dysfunction with Diabetes Mellitus type II: Hypothyroidism patients(0.46 ± 6.26) µIU/mL. T3 hormone was (187.84 ± 6.12) ng/dL, the highest resultin Thyroid Dysfunction with Diabetes Mellitus type Ⅱ: Hyperthyroidism patients. T4 was highest hormonal level in Thyroid Dysfunction with Diabetes Mellitus type II: Hyperthyroidism patients which was (14.02 ± 0.56) ng/dL. Fasting blood sugar (serum) measured a highly significant differences and highest level in patients who suffered from thyroid Dysfunction with Diabetes Mellitus type II: Hypothyroidism with (190.50 ± 12.72) mg/dL. Glycated hemoglobin (HbA1c) measured high significant differences with (11.13 ± 0.55) mmoL/L in patients of diabetes type II. Cholesterol, Triglyceride, LDL-C and VLDL-C high significant differences and highest levels were among patients with Thyroid Dysfunction with Diabetes Mellitus type II: Hypothyroidism with (209.45 ±12.29, 268.18 ±31.57, 114.24 ±13.74 and 55.98 ±5.63) mg/dL respectively, while HDL-C was significantly higher in control group. The Adiponectin had high significant differences among ","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"31 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140420623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous fractures in healthy postmenopausal women aged 55+ years in two health centers: Laquintinie Hospital and General Hospital, Douala, Cameroon","authors":"Aline BAMIA, Rama Natacha SONGUE, Andréa ADIOGO, Sebastien OMBOTO, Dieudonné Désiré ADIOGO","doi":"10.30574/gscbps.2024.26.2.0038","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0038","url":null,"abstract":"Background: Women in their old age are facing some health issues due to physiological changes. It was observed many cases of osteoporosis during menopause. At that stage of their life, women undergo ovaries atrophy caused by hormonal imbalance. Estrogen deficiency is a leading cause of osteoporosis in postmenopausal women. That is why at menopause when its level drops women have fragile bones and are prone to fractures of many kinds. Fractures are associated with a high risk of morbidity which is why we aimed to identify and characterize the state of fractures in older women during menopause in our country. Method: A survey was performed at the orthopedic-traumatology and rheumatology unit of 2 different health centers: Laquintinie Hospital of Douala and Douala General Hospital (DGH). Files of postmenopausal women admitted for fracture were screened. The data were analyzed by SPSS and statistical significance was considered when P-value < 0.05. Results: 643 files of postmenopausal women admitted for fractures were analyzed. Results showed that 29% (186/643) of women at menopause aged above 55 years old had spontaneous fractures. The mean age was 71.89 years, ranging from 55 to 119 years. Falls and domestic accidents were the top two most represented causes (38.2 and 31.7 % respectively). Among those fractures, 70% happened after minimal trauma. The wrist was the favorite anatomical site for patients aged ranged between 55-64 years. As for UEF (Upper end of the femur) fracture, it increased in an age-related manner. Absence of trauma was observed the less in population aged between 55 and 64 years (11.5% ; P<0.001); and it was highest in women aged 85+ years (64%). Conclusion: Postmenopausal women in our population have disabilities due to spontaneous fractures which impact negatively their quality of life. We should spread awareness among women before they reach menopause to take suitable measures to reduce the incidence of fractures and related morbidity at a certain age.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"57 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriological and physiochemical evaluation of locally produced tiger nut drink (kunu aya) sold in Owerri metropolis Imo state Nigeria","authors":"Ijeoma Desline Ejikeme, Sylvester Ifunanya Okorondu, Ikenna Ndubuisi Nwachukwu","doi":"10.30574/gscbps.2024.26.2.0041","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0041","url":null,"abstract":"The public heath implication of consumption of contaminated and unregulated hawked drinks has received great attention in recent times. This work investigated succession parameters of micro-organisms and physiochemical characteristics of tiger nut (Cyperus esculentus) drink hawked in Owerri metropolis over a 72 hour period. Samples of freshly produced drinks were purchased from seven major locations (Ekeonuwa, Control, Ikenegbu, Futo campus, Ihiagwa, Obinze and Naze junction) in Owerri metropolis. Microbial evaluation of the drink samples was carried out using spread plate method. Physiochemical analysis of tiger nut drinks were carried out using standard A.O.A.C methods. The results indicated the presence of Staphyloccus sp, Microccus sp, Enterobacter sp, Bacillus subtilis, Bacillus cereus, Salmonella sp, Escherichia coli and Corynebacterium sp. These contrasted from organisms isolated from laboratory prepared control. The mean total bacterial counts indicated tiger nut drink sold around Naze recorded the highest total heterotrophic bacterial count (109 CFU/ml), tiger nut drinks sold at FUTO campus, Obinze and Ihiagwa recorded the highest total fecal coliform count (104 CFU/ml) and total Salmonella-Shigella count (104 CFU/ml), while the laboratory prepared recorded the least heterotrophic bacterial count (103 CFU/ml), zero total fecal coliform count and total Salmonella-Shigella count recorded. The pH and titratable acidity over a 72 hour period indicated that all the drinks were acidic, where the street sold drinks recorded the highest acidity compared to the laboratory prepared drink. Very low microbial count observed for the laboratory prepared tiger nut drinks underscores the importance of Good Manufacturing Practices (GMP). It is recommended that regulatory government agencies for food and drink products should step up campaign for adoption/implementation of GMP by local vendors/producers.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete blood count changes in sudden sensorineural hearing loss caused by Streptococcus suis bacterial meningitis at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar from January 2019 – May 2023","authors":"Maximiliano Agustian Mahardhika, I Made Wiranadha, I Gede Made Ardika Aryasa","doi":"10.30574/gscbps.2024.26.2.0074","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0074","url":null,"abstract":"Introduction: Sudden sensorineural hearing loss (SSNHL) is an emergency case that requires immediate and comprehensive management. This condition can be caused by Streptococcus suis bacterial meningitis. Complete blood counts (CBC) examinations are often carried out in SSNHL patients that caused by infection. Some CBC components can be clinical indicators of the severity and prognosis of SSNHL. Objective: To find out the differences in CBC among S. suis bacterial meningitis patients with SSNHL and S. suis bacterial meningitis patients with normal hearing at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar from January 2019 – May 2023. Methods: This study used an analytical research design using a retrospective case control method to compare CBC results (hematocrit, NLR, PLR, MLR, RDW and MPV) in 40 cases patients with SSNHL due to S. suis bacterial meningitis and 40 controls patients with S. suis bacterial meningitis patients with normal hearing. Result: In this study, it was found that there is no significant difference between case group compared to control group in terms of CBC results. The mean hematocrit value was 40.67 (± 4.45) in cases and 40.87 (± 4.08) in controls, with p-value 0.842. The mean MPV value was 9.82 (± 1.58) in cases and 9.33 (± 1.78) in controls, with p-value 0.200. The mean NLR value in the case group was 24.46, while in the control group it was 28.79, with p-value 0.124. The mean PLR value in the case group was 200.01, while in the control group it was 247.80, with p-value 0.126. The mean MLR value was 1.33 in cases and 1.19 in controls, with p-value 0.303. The mean RDW value was 12.98 in cases and 12.81 in controls, with p-value 0.950. Conclusion: From 40 people suffering SSNHL due to S. suis bacterial meningitis it was found that most of research subjects are men (75%) and the average age of subjects is 53 years. This study found that there were no significant differences between the results of mean hematocrit, NLR, PLR, MLR, RDW and MPV in patients with SSNHL due to S. suis bacterial meningitis compared to controls.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"21 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive phytochemicals in Annona muricata fruit juice ethanol extract","authors":"Caryne Chidinma Ezerioha, Chiedozie Onyejiaka Ibegbulem, Chinyere Henrietta Onuoha, Favour Iruomachukwu Akudinobi, Chinaza Shedrach Dike, Arthur Chukwudubem Morah","doi":"10.30574/gscbps.2024.26.2.0034","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0034","url":null,"abstract":"Phytochemical contents of Annona muricata fruit juice ethanol extract was determined using gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC). Lyophilized fruit juices were extracted in 10 % v/v aqueous solution of ethanol at 60 0C in a water bath. The GC-MS screening of the extract revealed the concentrations (mg/ml) of thirty-three (33) phytochemicals which included glycerine (9.12), levoglucosenone (5.18), 1,3-propanediol-2-(hydroxymethyl)-2-nitrobenzene (11.83) and D- allose (7.28), benzofuran-2,3-diydro-(1.87), 3,7,11,15-tetramethyl-2-hexadecen-1-ol (1.52), Cis-11,14-Eicosadienoic acid, methyl ester (1.53), 9-Octadecenoic acid, methyl ester (1.68), 2-Methoxy-4-vinylphenol (1.69), which are reported to exhibit various biological activities. The HPLC analyses of the extract revealed various polyphenolic compounds (mg/ml) such as naringenin (12.97), proanthocyanin (0.23), tannin (44.17), coumaric acid (4.12), catechin (39.20), resveratrol (42.27) and kaempferol (29.86). which also possess various health benefits like antibacterial, antifungal, anti-inflammatory, anticancer, antimutagenic, antioxidant, antitumor, and others. It can be concluded that the Annona muricata fruit juice ethanol extract contained bioactive phytochemicals that exhibit promising health-promoting activities.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"21 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, phytonutrients, the nutraceutical, and mineral analysis of coconut (Cocos nucifera) oil","authors":"Tolulope Margret ILESANMI, Dayo Mary FAKOMITI","doi":"10.30574/gscbps.2024.26.2.0039","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0039","url":null,"abstract":"Coconut oil is edible oil which is derived from the kernels, meat, and milk of the coconut palm fruit. This study aimed at evaluating the physicochemical properties, mineral elements, phytochemical content of coconut oil and determines the susceptibility pattern of coconut oil against bacteria. The results revealed the average values of the coconut oil contains for alkaloid, tannin, saponins, flavonoid, phenol, steroid, terpenoid, and glycoside were 38.230 mg/100g, 28.124 mg/100g, 16.185 mg/100g, 29.745 mg/100g, 79.167 mg/100g, 0.915 mg/100g, 1.251 mg/100g, and 0.506 mg/100g respectively; which are considered to be responsible for the many benefits attributed to coconut consumption. The mineral elements such sodium (75.350 ppm), calcium (105.400 ppm), potassium (502.55 ppm), magnesium (24.502 ppm), phosphorus (20.372 ppm), and copper, zinc, iron and manganese were present in moderate amounts of 0.442 ppm, 0.393 ppm, 0.772 ppm, 0.629 ppm respectively. The physicochemical analysis reveal the pH level to be neutral, while other parameters such as nitrate, phosphate and ammonia were not detected. The assay of antibacterial activity of standard bacteria organisms showed that Staphylococcus aureus had the highest susceptibility to coconut oil while Pseudomonas aeruginosa had the least. The utilization of coconut oil should be promoted as a functional food in Nigeria and the use of coconut seed flesh in our diets should be encouraged for health supporting functions.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of efficacy and safety of drugs in stage I hypertensive patients attending cardiac OPD at tertiary care hospital","authors":"Korrapati Rajini Naidu, SK Harshiya","doi":"10.30574/gscbps.2024.26.2.0052","DOIUrl":"https://doi.org/10.30574/gscbps.2024.26.2.0052","url":null,"abstract":"To study the efficacy and safety profile of Azilsartan 40 mg and Olmesartan 40 mg in stage I systemic Hypertension among patients attending cardiac OPD in a tertiary care center. All patients with stage I systemic hypertension of either sex, aged 20-65 years, with blood pressures of >140/90 mmHg or diabetes mellitus attending the cardiac outpatient. After initial screening, diagnosed cases of essential hypertension were randomly allocated to either group 1 (Tablet Azilsartan 40 mg or group 2 (Tablet Olmesartan 40 mg). The patients were advised to report for follow-up for review on the 4th, 8th, 12th, and 24th week.The mean decrease in the systolic blood pressure in both groups was statistically significant with a P value of <0.0000001. Both drugs controlled blood pressure at similar proportions. However, the mean of SBP and DBP for the Azilsartan group was lower than the Olmesartan Group. Both drugs were tolerated well, and no significant adverse effects were noted during the study.","PeriodicalId":12808,"journal":{"name":"GSC Biological and Pharmaceutical Sciences","volume":"33 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}