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Promotion of a new gap junction gene Cx46 (GJA3) expression in the cochlea after Cx26 (GJB2) deficiency Cx26 （GJB2）缺乏后耳蜗新间隙连接基因Cx46 （GJA3）表达的促进

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.heares.2025.109454

Tian-Ying Zhai , Jin Chen , Yong Kong , Chun Liang , Hong-Bo Zhao

Gap junction GJB2 (connexin 26, Cx26) gene mutations are responsible for >50 % of nonsyndromic hearing loss. The pathological changes mainly locate in the cochlea. However, little is known about genetic changes in the cochlea after Cx26 deficiency. In this study, we employed bulk Poly(A) RNA-Seq technique and found that Cx26 deficiency could cause many genes up- and down-regulated in the cochlea. One of the unexpected findings is significant upregulation of a gap junctional gene GJA3 (Cx46), which normally expresses in the eye rather than the ear. Quantitative PCR and digital droplet PCR further confirmed the promotion of Cx46 expression in the cochlea after Cx26 deficiency. Immunofluorescent staining showed that the promoted Cx46 was expressed at the same location as Cx26 expression in the cochlea and integrated into the same gap junctional plaques. This promotion is Cx26-specific; there was no promotion of Cx46 expression in the cochlea after knockout (KO) of Cx30 (GJB6), which is another predominant connexin co-expressed in the cochlea. Gene Set Enrichment Analysis (GSEA) revealed that Cx26 deficiency but not Cx30 KO upregulated a phototransduction pathway to promote the eye-specific gene Cx46 expression in the cochlea. This may present a natural compensation to the loss of Cx26 function, since both Cx26 and Cx46 have similar channel properties. Our findings also provide a new cue for developing a genetic approach to treat this common hereditary deafness.

间隙连接GJB2（连接蛋白26，Cx26）基因突变导致50%的非综合征性听力损失。病理改变主要发生在耳蜗。然而，对Cx26缺乏后耳蜗的遗传变化知之甚少。在本研究中，我们采用了bulk Poly(A) RNA-Seq技术，发现Cx26缺乏会导致耳蜗中许多基因的上调和下调。其中一个意想不到的发现是间隙连接基因GJA3 （Cx46）的显著上调，该基因通常在眼睛而不是耳朵中表达。定量PCR和数字液滴PCR进一步证实了Cx26缺乏后耳蜗中Cx46表达的促进作用。免疫荧光染色显示，促进的Cx46与Cx26在耳蜗中的表达位置相同，并整合到相同的间隙连接斑块中。这个促销是cx26特有的；Cx30 （GJB6）是耳蜗中另一种主要的共表达连接蛋白，敲除（KO） Cx30 （GJB6）后，耳蜗中Cx46的表达未得到促进。基因集富集分析（GSEA）显示，Cx26缺乏而非Cx30 KO上调了一条光导通路，促进了耳蜗中眼睛特异性基因Cx46的表达。这可能是对Cx26功能损失的自然补偿，因为Cx26和Cx46都具有相似的通道属性。我们的发现也为开发一种治疗这种常见遗传性耳聋的遗传方法提供了新的线索。

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引用次数: 0

Unraveling the genetic basis of post-infancy diagnosed sensorineural hearing loss using whole exome sequencing 利用全外显子组测序揭示婴儿后诊断的感音神经性听力损失的遗传基础

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.heares.2025.109455

Weitao Li , Sha Yu , Biyun Zhu , Liheng Chen , Huawei Li , Luo Guo , Yilai Shu , Bing Chen

Objective

To clarify the genetic causes and the mutation spectrum of post-infancy diagnosed sensorineural hearing loss in the Chinese population.

Methods

We enrolled patients with post-infancy diagnosed bilateral sensorineural hearing loss (onset age between 1 and 60 years) at the Eye & ENT Hospital of Fudan University from November 2018 to October 2022. Whole-exome-sequencing (WES) was performed to elucidate the genetic etiology of these patients. Additionally, the frequency of common deafness variants was retrospectively analyzed and compared to previous studies.

Results

In this study, 146 patients with post-infancy diagnosed sensorineural hearing loss received WES, of which 93 patients had a positive molecular diagnosis, with an overall diagnostic rate of 63.7 %. A total of 107 variants across 50 deafness-related genes were identified. Among the diagnosed patients, GJB2: c.109G>A (11.6 %), GJB2: c.235delC (7.2 %), SLC26A4: c.919–2A>G (5.1 %), MPZL2: c.220C>T (2.4 %), and SLC26A4: c.2168A>G (2.1 %) were the five variants with the highest frequency. The diagnostic rate in the patients with inner ear malformations (100 % vs 59.5 %, P < 0.05) and patients with onset before age of 18 years (68.9 % vs 48.7 %, P < 0.05) was significantly higher than in patients without inner ear malformations and with an onset after age of 18 years.

Conclusion

This study has preliminarily outlined the spectrum of gene mutations associated with deafness in patients with post-infancy diagnosed hearing loss within the Chinese population. We identified 15 novel pathogenic or likely pathogenic variants, indicating that the GJB2 c.109G>A is the most common variant in post-infancy diagnosed hearing loss patients, and the proportion of patients with MPZL2 variants is higher than expected. Our study provides valid evidence to support subsequent genetic testing for patients with post-infancy diagnosed hearing loss.

目的了解中国婴幼儿后诊断的感音神经性听力损失的遗传原因和突变谱。方法纳入2018年11月至2022年10月在复旦大学眼科及耳鼻喉科医院就诊的婴幼儿后诊断为双侧感音神经性听力损失的患者（发病年龄1 ~ 60岁）。采用全外显子组测序（WES）来阐明这些患者的遗传病因。此外，对常见耳聋变异的频率进行回顾性分析，并与以往的研究进行比较。结果146例婴儿期后诊断为感音神经性听力损失的患者行WES检查，其中分子诊断阳性93例，总诊断率为63.7%。在50个耳聋相关基因中共鉴定出107个变异。在确诊患者中，GJB2: c.109G>；A（11.6%）、GJB2: c.235delC（7.2%）、SLC26A4: c.919-2A>；G（5.1%）、MPZL2: c.220C>；T（2.4%）、SLC26A4: c.2168A>；G（2.1%）是5种频率最高的变异。内耳畸形患者的诊断率（100% vs 59.5%, P < 0.05）和18岁前发病患者的诊断率（68.9% vs 48.7%, P < 0.05）显著高于无内耳畸形患者和18岁后发病患者。结论本研究初步勾勒出中国婴幼儿后听力损失患者耳聋相关基因突变谱。我们发现了15种新的致病或可能致病的变异，表明GJB2 c.109G>；A是婴儿期后诊断为听力损失的患者中最常见的变异，而MPZL2变异的患者比例高于预期。我们的研究提供了有效的证据，支持对婴儿期后诊断为听力损失的患者进行后续基因检测。

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引用次数: 0

ABR Wave I is enhanced with 4 kHz chirp compared to traditional broadband click 与传统宽带点击相比，ABR波I增强了4 kHz啁啾。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-31 DOI: 10.1016/j.heares.2025.109467

Carly Furlong , Akshay R Maggu

The Wave I of the Auditory Brainstem Response (ABR) has been increasingly proposed as a potential neural marker for subtle auditory-neural deficits. However, the existing standard click-evoked ABR protocols in humans are limited due to reduced amplitude and increased inter- and intra-subject variability of the recorded Wave I. Thus, there is a growing need for developing ABR protocols that could enhance the Wave I amplitude and reliability. To this end, in the current study, we compared a 4 kHz rising chirp with a conventional broadband click, each presented at suprathreshold level (i.e., 70 dB nHL) in 38 young adults with clinically normal hearing. Two within-session repetitions for each stimulus were recorded and Wave I peak-to-trough amplitude, peak to zero amplitude, peak latency, Wave I/V amplitude ratios, and within-session reliability (for amplitude and latency) were evaluated. Compared to click, the chirp produced significantly larger Wave I amplitudes but later Wave I latencies. Within-subject, within-session reliability was also higher for the chirp as compared to the traditional click. However, differences in effects between stimuli were not found for Wave V, though click latencies were modestly earlier than chirp. These findings suggest that a 4 kHz chirp stimulus may be a more viable stimulus for Wave I elicitation than standard click. This preliminary finding exhibits potential for future use of 4 kHz chirp stimuli in clinical evaluation for subtle auditory-neural deficits that otherwise may not be detected through standard electrophysiological measures.

听觉脑干反应（ABR）的第一波被越来越多地提出作为一种潜在的听觉神经缺陷的神经标志物。然而，由于所记录的波I的振幅降低和受试者之间和受试者内部的变异性增加，现有的人类点击诱发ABR标准协议受到限制。因此，越来越需要开发能够增强波I振幅和可靠性的ABR协议。为此，在目前的研究中，我们比较了38名临床听力正常的年轻成年人的4 kHz上升啁啾和传统宽带咔嗒声，每一种都在阈值以上水平（即70 dB nHL）。记录每个刺激的两次会话内重复，并评估波I波峰谷振幅、峰至零振幅、峰潜伏期、波I/V振幅比和会话内可靠性（振幅和潜伏期）。与咔嗒声相比，啁啾产生的波I幅度明显更大，但波I延迟更晚。在主题内，与传统的点击相比，唧唧声在会话内的可靠性也更高。然而，在波V中没有发现不同刺激的影响差异，尽管点击延迟比啁啾稍早。这些发现表明，4 kHz的啁啾刺激可能比标准的咔哒声更能激发波1。这一初步发现显示了未来在临床评估中使用4khz啁啾刺激的潜力，否则可能无法通过标准电生理测量检测到细微的听神经缺陷。

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引用次数: 0

Changes in primitive auditory memory in presbycusis and their impact on binaural auditory processing 老年性耳聋患者原始听觉记忆的变化及其对双耳听觉加工的影响。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-15 DOI: 10.1016/j.heares.2025.109451

Ruiqi Ruan , Junsheng Hong , Fan Yuan , Yefei Mo , Lingxiao Jiang , Yuhe Liu

Background

Presbycusis is common in ageing populations and often causes a significant decline in binaural auditory processing capabilities, disproportionate to peripheral hearing loss. Sound localisation and speech-in-noise segregation depend on processing temporal fine structure (TFS) information in reverberant environments. This requires transient storage and integration of TFS information, which is the primitive auditory memory (PAM) capacity. However, how presbycusis affects PAM remains unclear. Therefore, this study aimed to investigate how PAM is affected by age and hearing loss severity, and whether PAM explains declines in binaural processing abilities.

Methods

This study included 33 young adults with normal hearing, 45 older adults with normal hearing, and 118 older patients with varying degrees of presbycusis. All patients underwent a break-in-correlation test to assess the PAM capacity. Binaural auditory processing abilities were evaluated using the Speech Reception Threshold in Noise, Competing Sentence Test, and Dichotic Digit Listening test.

Results

PAM capacity declines in older adults, showing a significant correlation with low-frequency hearing loss. Even older adults with normal hearing exhibit age-related declines. Moreover, reduced PAM was associated with poor binaural processing. A PAM capacity <8 ms effectively identified processing deficits in older adults, indicating compromised temporal processing.

Conclusion

Age-related hearing loss influences early-stage binaural cue integration, which is closely associated with deterioration in binaural auditory processing. These findings advance our understanding of direct-to-reverberant sound integration and auditory processing mechanisms in complex acoustic environments.

背景：老年性耳聋在老年人群中很常见，经常导致双耳听觉处理能力显著下降，与周围性听力损失不成比例。声音定位和噪声中语音分离依赖于混响环境中时间精细结构（TFS）信息的处理。这需要瞬时存储和整合TFS信息，这是原始听觉记忆（PAM）能力。然而，老年性耳聋如何影响PAM仍不清楚。因此，本研究旨在探讨PAM如何受到年龄和听力损失严重程度的影响，以及PAM是否解释了双耳加工能力的下降。方法：本研究纳入听力正常的青年33例，听力正常的老年人45例，老年不同程度老年性耳聋患者118例。所有患者都进行了破断相关测试以评估PAM容量。采用语音接收阈值测试、竞争句测试和二分数字听力测试来评估双耳听觉处理能力。结果：老年人PAM容量下降，与低频听力损失有显著相关性。即使听力正常的老年人也会出现与年龄相关的衰退。此外，PAM减少与双耳处理不良有关。结论：年龄相关性听力损失影响早期双耳线索整合，并与双耳听觉加工的退化密切相关。这些发现促进了我们对复杂声环境中直接-混响声音整合和听觉加工机制的理解。

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引用次数: 0

Eye movements of younger and older adults decrease during story listening in background noise 在背景噪音下听故事时，年轻人和老年人的眼球运动减少

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1016/j.heares.2025.109447

Björn Herrmann , Florian Scharf , Andreas Widmann

Assessments of listening effort are increasingly relevant to understanding the speech-comprehension difficulties experienced by older adults. Pupillometry is the most common tool to assess listening effort but has limitations. Recent research has shown that eye movements decrease when listening is effortful and proposed indicators of eye movements as alternative measures. However, much of the work was conducted in younger adults in trial-based sentence-listening paradigms during concurrent visual stimulation. The extent to which eye movements index listening effort during continuous speech listening, independently of visual stimuli, and in older adults, is unknown. In the current study, younger and older adults listened to continuous stories with varying degrees of background noise under free and moving-dots viewing conditions. Eye movements decreased (as indexed by fixation duration, gaze dispersion, and saccade rate) with increasing speech masking. The reduction in eye movements did not depend on age group or viewing conditions, indicating that eye movements can be used to assess effects of speech masking in different visual situations and in people of different ages. The pupil size was only sensitive to speech masking early in the experiment. In sum, the current study suggests that eye movements are a potential tool to assess listening effort during continuous speech listening.

听力努力的评估与理解老年人所经历的语言理解困难越来越相关。瞳孔测量法是评估听力努力程度的最常用工具，但也有局限性。最近的研究表明，当努力倾听时，眼球运动减少，并提出了眼球运动指标作为替代措施。然而，大部分的研究是在年轻的成年人中进行的，在并行视觉刺激下，以句子-听力为基础的试验范式。在独立于视觉刺激的情况下，在老年人中，眼球运动在多大程度上反映了连续语音听力的努力程度，目前尚不清楚。在目前的研究中，年轻人和老年人在自由和移动点观看条件下听不同程度背景噪音的连续故事。随着言语掩蔽的增加，眼球运动减少（以注视时间、凝视分散和扫视率为指标）。眼球运动的减少并不取决于年龄组或观看条件，这表明眼球运动可以用来评估不同视觉情况和不同年龄人群的语音掩蔽效果。在实验早期，瞳孔大小只对语音掩蔽敏感。总而言之，目前的研究表明，眼球运动是评估连续语音听力过程中听力努力程度的潜在工具。

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引用次数: 0

Deciphering the ototoxic effects of six organochlorine pesticides on HEI-OC1 cells and mouse cochlear organotypic cultures 六种有机氯农药对HEI-OC1细胞和小鼠耳蜗器官型培养物的耳毒性作用

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-02 DOI: 10.1016/j.heares.2025.109443

Shuangshuang Mao , Ziying Zhang , Can Zhang, Zihong Zhou, Xiaohua Tan, Dandan Song, Jianyun Zhang, Yang Song, Yu Hong, Rong Chen

Organochlorine pesticides (OCPs), persistent pollutants with mutagenic and carcinogenic risks, that threatens humans, have received limited scientific attention despite their well-documented toxicity. Our study examined the ototoxicity of six prevalent OCPs (p,p’-DDT, p,p’-DDE, p,p’-DDD, Hexachlorocyclohexane, Endosulfan, Heptachlor) that are frequently identified in human biological samples, including blood and breast milk. Our findings revealed that OCPs caused cochlear damage in postnatal day 3 (P3) mice, and exhibited a dose-dependent toxicological response in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells. OCPs exposure led to the generation of ROS (H₂O₂, O₂⁻, mtROS), calcium overload, mitochondrial membrane potential (MMP) decrease, and endoplasmic reticulum (ER) stress activation. Western blot showed a marked reduction in the Bcl-2/Bax ratio, an elevated level of cleaved caspase-9/3, and four increased ER stress markers (p-eIF2α, ATF6, GRP78, CHOP). These results suggest that OCPs induce auditory cell apoptosis through interconnected pathways: oxidative stress, mitochondrial dysfunction, calcium dysregulation, and ER stress. This study provides mechanistic insights into OCP-related ototoxicity, emphasizing the need for stringent regulation of these pervasive environmental toxins.

有机氯农药（ocp）是一种具有致突变和致癌风险的持久性污染物，对人类构成威胁，尽管其毒性已得到充分证明，但科学关注有限。我们的研究检查了六种常见的ocp （p,p ' -DDT, p,p ' -DDE, p,p ' -DDD，六氯环己烷，硫丹，七氯）的耳毒性，这些ocp经常在人类生物样本中被发现，包括血液和母乳。我们的研究结果表明，OCPs可引起出生第3天（P3）小鼠的耳蜗损伤，并在House Ear Institute-Organ of Corti 1 （HEI-OC1）细胞中表现出剂量依赖性的毒理学反应。OCPs暴露导致ROS （h2o2₂，O₂⁻，mtROS）的产生，钙超载，线粒体膜电位（MMP）降低，内质网（ER）应激激活。Western blot结果显示Bcl-2/Bax比值明显降低，cleaved caspase-9/3水平升高，内质网应激标志物（p-eIF2α、ATF6、GRP78、CHOP）升高。这些结果表明OCPs通过相互关联的途径诱导听觉细胞凋亡：氧化应激、线粒体功能障碍、钙调节失调和内质网应激。这项研究提供了ocp相关耳毒性的机制见解，强调了对这些普遍存在的环境毒素进行严格监管的必要性。

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引用次数: 0

Effect of cognitive load on cervical vestibular evoked myogenic potentials 认知负荷对颈前庭诱发肌生成电位的影响。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-29 DOI: 10.1016/j.heares.2025.109466

Rahina Abubacker , Aravind Kumar Rajasekaran , Anannya Adhikari , Muralidharan Kesavan , Pradeep Yuvaraj

While vestibular responses have traditionally been viewed as reflexive and brainstem-mediated, emerging evidence suggests they are susceptible to modulation by higher-order cognitive processes. This study aimed to investigate the influence of cognitive load, induced by the Stroop task, on Cervical Vestibular Evoked Myogenic Potentials (cVEMPs) in healthy young adults. Thirty healthy right-handed participants (aged 20–25 years) with no history of audio-vestibular, neurological, or musculoskeletal conditions underwent baseline and dual-task cVEMP recordings. The dual-task condition involved the visual Stroop task presented concurrently with acoustic stimulation. Latency (P1, N1) and amplitude (P1–N1) parameters were extracted from the cVEMP waveforms and compared across conditions. All participants exhibited identifiable cVEMP responses under both conditions. A statistically significant reduction in P1–N1 amplitude was observed during the Stroop task compared to baseline (p < 0.02), while P1 and N1 latencies remained unchanged. The asymmetry ratio did not differ significantly between conditions. These findings suggest that cognitive state should be considered during vestibular testing and support the growing recognition of central cognitive influences on vestibular processing. Cognitive load significantly attenuates cVEMP amplitude without affecting latency, suggesting top-down modulation of vestibular reflex strength.

虽然前庭反应传统上被认为是反射性的和脑干介导的，但新出现的证据表明，它们容易受到高阶认知过程的调节。本研究旨在探讨Stroop任务诱导的认知负荷对健康青年颈前庭诱发肌源性电位（cemps）的影响。30名健康的右撇子参与者（年龄20-25岁），无前庭、神经或肌肉骨骼病史，接受基线和双任务cemp记录。双任务条件包括视觉Stroop任务与声刺激同时出现。从cemp波形中提取潜伏期（P1, N1）和振幅（P1-N1）参数，并在不同条件下进行比较。在两种情况下，所有参与者都表现出可识别的cemp反应。与基线相比，在Stroop任务期间观察到P1-N1振幅的统计学显著降低（p < 0.02），而P1和N1潜伏期保持不变。不对称比例在不同条件下无显著差异。这些发现表明，在前庭测试中应考虑认知状态，并支持对前庭加工中枢认知影响的日益认识。认知负荷显著减弱cemp振幅，但不影响潜伏期，提示前庭反射强度自上而下调节。

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引用次数: 0

Clinical improvement of speech perception in noise with Automatic Sound Management 3.0 自动声音管理3.0对噪声中语音感知的临床改善

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-04 DOI: 10.1016/j.heares.2025.109445

Andreas Büchner , Tobias Rottmann , Thomas Lenarz , Anke Lesinski-Schiedat , Ernst Aschbacher , Florian Frühauf , Timo Bräcker , Mareike Billinger-Finke

Objectives

Cochlear implant (CI) users face significant challenges with the perception of speech in noise and in other complex acoustic environments. This study evaluated the effects of a new front-end signal processing framework, Automatic Sound Management 3.0 (ASM 3.0), on the perception of speech in noise by CI users tested with the RONDO 3 and SONNET 2 audio processors.

Design

20 experienced CI users participated in this study. Speech perception in noise was evaluated in two speech–noise configurations: spatially co-located speech and noise (S₀N₀) and spatially separated speech and noise with multiple noise sources (S₀N_±90N₁₈₀). Performance was compared between ASM 3.0 and its predecessor ASM 1.0, as well as between the RONDO 3 and SONNET 2 audio processors. Two validated patient-reported instruments were administered to assess user experiences with the RONDO 3.

Results

Compared to ASM 1.0, ASM 3.0 facilitated significant improvements to speech perception in spatially separated noise with both the RONDO 3 (mean SRT₈₀ improvement: 4.1 dB) and the SONNET 2 (mean SRT₈₀ improvement: 4.4 dB). ASM 3.0 did not yield significant improvements to speech perception in spatially co-located noise with the RONDO 3 (mean SRT₈₀ improvement: 1.2 dB) although this performance gain compares well with the one found for the SONNET 2 in other studies. RONDO 3 users reported high levels of satisfaction on the Audio Processor Satisfaction Questionnaire (mean total score: 8.7/10) and on self-reported hearing quality on the Hearing Implant Sound Quality Index (HISQUI₁₉) (mean total score: 84.8/133).

Conclusions

ASM 3.0 facilitated substantial and clinically meaningful improvements in speech perception in spatially separated noise. Improvements were smaller and were not significant for speech perception in co-located noise. Use of the RONDO 3 generally lead to a high level of satisfaction with the processor and a high perceived sound quality in everyday life.

目的人工耳蜗使用者在噪声和其他复杂声环境下的语音感知面临重大挑战。本研究评估了一个新的前端信号处理框架，自动声音管理3.0 （ASM 3.0）对使用RONDO 3和SONNET 2音频处理器的CI用户在噪声中感知语音的影响。Design20经验丰富的CI用户参与了本研究。在两种语音-噪声配置下，对噪声下的语音感知进行了评价：空间共存的语音和噪声（S0N±90N180）和空间分离的多个噪声源的语音和噪声（S0N±90N180）。ASM 3.0和它的前身ASM 1.0，以及RONDO 3和SONNET 2音频处理器之间的性能进行了比较。使用两种经过验证的患者报告的仪器来评估RONDO 3的用户体验。结果与ASM 1.0相比，ASM 3.0显著改善了空间分离噪声下的语音感知，RONDO 3（平均SRT80改善4.1 dB）和SONNET 2（平均SRT80改善4.4 dB）均有显著改善。ASM 3.0与RONDO 3在空间共定位噪声中的语音感知没有显著改善（平均SRT80改善：1.2 dB），尽管这种性能增益与其他研究中SONNET 2的性能增益相比要好得多。RONDO 3用户对音频处理器满意度问卷（平均总分：8.7/10）和听力植入物音质指数（HISQUI19）自我报告的听力质量（平均总分：84.8/133）的满意度很高。结论asm 3.0可显著改善空间分离噪声下的语音感知，具有临床意义。在同处噪声环境下，语音感知的改善较小且不显著。在日常生活中，使用RONDO 3通常会对处理器和高感知音质产生高水平的满意度。

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引用次数: 0

The neurochemistry of decreased sound tolerance: A magnetic resonance spectroscopy (MRS) study of misophonia and hyperacusis 声音耐受能力下降的神经化学：恐音症和听觉亢进的磁共振波谱研究

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI: 10.1016/j.heares.2025.109440

Jamie Ward , Romarua Agbude , Rebecca Smees , Julia Simner , Itamar Ronen

This study examined the concentrations of excitatory and inhibitory neurotransmitters (glutamate and GABA respectively) in two regions of interest (auditory and insular cortices) and a control region (visual cortex) to test the hypothesis that decreased sound tolerance would be linked to increased cortical excitability (more glutamate and/or less GABA). Misophonia (negative emotional responses to specific sounds) and hyperacusis (finding sounds atypically loud) were separately considered and key comorbidities excluded (tinnitus, migraine, autism). A MEGA-PRESS sequence was used for auditory cortex to optimise the detection of GABA. We found no significant group differences in neurotransmitter in any region and pre-registered Bayesian analyses suggested that these are sensitive null results. These findings argue against the idea that decreased sound tolerances are linked to neurochemically-driven differences in excitation/inhibition.

本研究检测了兴奋性和抑制性神经递质（分别为谷氨酸和GABA）在两个感兴趣的区域（听觉和岛叶皮层）和一个控制区域（视觉皮层）的浓度，以验证声音耐受性降低与皮层兴奋性增加（谷氨酸和/或GABA减少）有关的假设。恐音症（对特定声音的负面情绪反应）和听觉亢进（发现声音异常响亮）被单独考虑，并排除了关键的合并症（耳鸣、偏头痛、自闭症）。在听觉皮层使用MEGA-PRESS序列来优化GABA的检测。我们发现在任何区域的神经递质没有显著的组差异，预注册贝叶斯分析表明这些是敏感的零结果。这些发现反驳了声音耐受性下降与神经化学驱动的兴奋/抑制差异有关的观点。

引用次数: 0

Corrigendum to “Unraveling eye movement-related eardrum oscillations (EMREOs): how saccade direction and tympanometric measurements relate to their amplitude and time course” [Hearing Research, Volume 461(2025), 109276] “解开眼动相关的鼓膜振荡（EMREOs）：如何扫视方向和鼓膜测量与它们的振幅和时间过程相关”的勘误表[听力研究，461卷（2025），109276]。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-11-01 Epub Date: 2025-10-08 DOI: 10.1016/j.heares.2025.109438

Nancy Sotero Silva , Christoph Kayser , Felix Bröhl

引用次数: 0