Hearing Research最新文献_第9页

An immersive ecological measure of noise-induced functional interference in adults with hyperacusis 一个沉浸式生态测量的噪音引起的功能干扰成人与听觉亢进。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-28 DOI: 10.1016/j.heares.2025.109465

Pierre H. Bourez , Guillaume T. Vallet , Nathalie Gosselin , François Bergeron , Philippe Fournier

Noise interfering with everyday activities is a common experience in many daily soundscapes. However, for individuals with intolerance to loud sounds, a condition called hyperacusis, these soundscapes can have a severe impact, greatly impairing lifestyle habits such as work, hobbies and social interactions. Yet, there is little experimental evidence documenting the functional impact of noise in these individuals. This study aims to validate a novel, ecologically relevant task designed to measure the functional impact of noise during a common daily activity: reading. Forty-nine participants (29 controls, 20 with hyperacusis) read a book excerpt while exposed to four different soundscapes. The sound level was gradually increased until participants reported that the noise interfered with their reading ability (called annoyance level), and then further increased until it became uncomfortable (called discomfort level). Participants then performed a 2-back cognitive task both in silence and in noise calibrated to their individual annoyance threshold. On average, individuals with hyperacusis reached these thresholds at sound levels 13 dB LAeq lower than controls. However, at their respective annoyance thresholds, both groups showed similar performance decrements (−3 %) in noise versus quiet. These findings support the validity of a novel ecological measure that integrates subjective annoyance thresholds with cognitive performance on a behavioral task, offering a reproducible approach to quantify the functional impact of hyperacusis.

干扰日常活动的噪音在许多日常声景中是一种常见的体验。然而，对于那些不能忍受大声声音的人来说，这些音景会产生严重的影响，极大地影响他们的生活习惯，比如工作、爱好和社交。然而，很少有实验证据证明噪音对这些人的功能影响。本研究旨在验证一种新颖的、与生态相关的任务，该任务旨在测量日常活动（阅读）中噪音对功能的影响。49名参与者（对照组29人，听觉亢进者20人）一边听着四种不同的音景，一边读一段书的节选。声音水平逐渐提高，直到参与者报告噪音干扰了他们的阅读能力（称为烦恼水平），然后进一步提高，直到它变得不舒服（称为不适水平）。然后，参与者在安静和噪音环境中进行了两项认知任务，根据他们的个人烦恼阈值进行了校准。平均而言，患有听觉亢进的个体达到这些阈值的声音水平比对照组低13 dB LAeq。然而，在各自的烦恼阈值下，两组在噪音和安静方面表现出相似的性能下降（- 3%）。这些发现支持了一种新的生态测量方法的有效性，该方法将主观烦恼阈值与行为任务中的认知表现结合起来，提供了一种可重复的方法来量化听觉亢进的功能影响。

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引用次数: 0

Perspectives on self-management of noise intrusion in daily living with hyperacusis 听觉过敏症患者日常生活噪音干扰自我管理的观点。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-15 DOI: 10.1016/j.heares.2025.109452

Nicolas Dauman , Soly I. Erlandsson , Alain Londero , Marc Fagelson

Background

Previous studies on noise intolerance have recommended further research into the lived experience of hyperacusis in order to better understand the specific needs and strategies used by those affected. We conducted a study with an inductive approach in which individuals with hyperacusis were willing to share their experiences.

Objective

To build a theoretical framework, based on the perspective of individuals with hyperacusis, that incorporates the behavior patterns underlying their participation in social contexts.

Method

The study population (N=29) included 12 females and 17 males (mean age 45 years) who had severe hyperacusis (mean HQ score 31). Open-ended interviews were conducted, and classic Grounded Theory (GT) was applied for the analysis of collected data.

Results

Participants’ main concern was related to intrusive feelings of being trapped by noise. In order to overcome noise intrusion, they expressed the need to alternate between a) moving away from challenging sound environments and b) setting clear goals in social participation. Participants’ ability to take initiative in the auditory scene, and to put aversive bodily sensations into perspective, contributed to their ability to stay in noisy environments. Furthermore, access to restorative environments (e.g. walking in the forest or by the sea) helped them replenish the ability to remain attentive in noisy environments.

Conclusions

Considering the needs expressed by patients with hyperacusis contributes to clinical management by identifying the adaptive behaviors underlying social participation. Furthermore, hypotheses about barriers and facilitators to sound exposure can be tested in future research.

背景：先前关于噪音不耐受的研究建议进一步研究耳鸣患者的生活经历，以便更好地了解受影响者的具体需求和策略。我们进行了一项研究与归纳的方法，其中个人与超听觉愿意分享他们的经验。目的：基于听觉亢进个体的视角，构建一个包含其社会参与行为模式的理论框架。方法：研究人群29例，女性12例，男性17例，平均年龄45岁，平均HQ评分31分。采用开放式访谈法，运用经典扎根理论（Grounded Theory， GT）对收集到的数据进行分析。结果：参与者主要担心的是被噪音困住的侵入感。为了克服噪音干扰，他们表示需要在a)远离具有挑战性的声音环境和b)设定明确的社会参与目标之间进行选择。参与者在听觉场景中采取主动的能力，以及把厌恶的身体感觉放在正确的角度，有助于他们在嘈杂的环境中保持的能力。此外，进入恢复性环境（例如在森林或海边散步）有助于他们补充在嘈杂环境中保持注意力的能力。结论：通过识别社会参与下的适应行为，考虑听觉亢进患者表达的需求有助于临床管理。此外，关于声音暴露障碍和促进因素的假设可以在未来的研究中得到验证。

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引用次数: 0

Effects of speaker and listener sex on auditory attention decoding performance 说话者和听者性别对听觉注意解码表现的影响。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-04 DOI: 10.1016/j.heares.2025.109444

Iris Van de Ryck , Nicolas Heintz , Iustina Rotaru , Debora Fieberg , Alexander Bertrand , Tom Francart

Objectives

Auditory Attention Decoding (AAD) is a technique utilizing brain signals to decode on which sound the listener focuses the attention. In most current studies, the effect of type of speech materials used and sex of the listener is not considered. We investigated the effect on AAD performance of factors related to the speaker (such as the sex of the speaker, background noise level, and same versus mixed-sex conditions) and the listener (sex of the listener).

Design

Forty-two young adults with normal hearing participated in the study. They listened to 2 competing speakers and were instructed to attend to one speaker and ignore the other speaker, whilst electroencephalography (EEG) and electrooculography (EOG) were measured. Background noise was introduced in half of the conditions. AAD performance was compared across eight experimental conditions.

Results

A significant main effect of speaker sex was found: A male target and/or male masker speaker resulted in higher AAD performance compared to a female speaker with a higher fundamental frequency (F0). These effects were found to be small and therefore likely clinically irrelevant.

Conclusion

While no substantial effects were found on the factors investigated in this study, including diverse and realistic training scenarios remains a valuable approach to prevent potential influences from other factors.

目的：听觉注意解码（AAD）是一种利用大脑信号来解码听者集中注意力的声音的技术。在目前的大多数研究中，没有考虑言语材料类型和听者性别的影响。我们调查了与说话者（如说话者的性别、背景噪音水平、同性或混合性别条件）和听者（听者的性别）相关的因素对AAD表现的影响。设计：42名听力正常的年轻人参加了这项研究。他们听了两个相互竞争的说话者，并被指示注意一个说话者而忽略另一个说话者，同时测量脑电图（EEG）和眼电图（EOG）。在一半的条件下引入了背景噪音。比较了8种实验条件下的AAD性能。结果：我们发现了说话者性别的显著主要影响：与基频（F0）较高的女性说话者相比，男性目标和/或男性掩蔽者的AAD表现更高。发现这些影响很小，因此可能与临床无关。结论：虽然本研究中所调查的因素没有发现实质性的影响，但包括多样化和现实的训练场景仍然是防止其他因素潜在影响的有价值的方法。

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引用次数: 0

Flow field dynamics in the pumping function of eustachian tube under varied middle ear pressure states 不同中耳压力状态下咽鼓管泵送功能的流场动力学。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1016/j.heares.2025.109446

Haoze Zhang , Zhenhao Fu , Jingcheng Zhou , Yulin Ding , Xiaolong Li , Mengyuan Guo , Shiming Yang , Fangyuan Wang , Zhaohui Hou

The Eustachian tube, a conduit linking the tympanic cavity to the nasopharynx, poses challenges for observation of its pressure dynamics due to its concealed anatomical position. Furthermore, computational models have not yet accurately replicated its intricate structure. We propose that simplification of the Eustachian tube’s structure may represent a crucial step toward elucidating the mechanisms underlying intraluminal pressure variation. In the present study, simplified models were constructed from CT scans of patients with patulous Eustachian tube. These models captured the tube’s key morphological features, including a blind-ended tubular structure with a sealed tympanic orifice, an open pharyngeal orifice, and a deformable central segment. Particle image velocimetry (PIV) was used to enable visualization of flow field alterations within the lumen during the transition from a closed to an open state under various simulated middle ear pressure conditions. The following phenomena were observed: (1) Bidirectional pumping at the onset of intraluminal negative pressure, characterized by simultaneous suction from both sides toward the center; (2) Variation of the pumping phenomenon under different middle ear pressure conditions; (3) Vortex generation at the tympanic orifice upon tubal opening under middle ear negative pressure. These findings provide novel insights into the functional mechanics of the Eustachian tube, and offer supporting evidence for the surgical rationale of myringotomy with grommet insertion in patients with otitis media with effusion (OME).

耳咽管是连接鼓室和鼻咽的管道，由于其隐蔽的解剖位置，对其压力动态的观察提出了挑战。此外，计算模型还不能精确地复制其复杂的结构。我们认为耳咽管结构的简化可能是阐明腔内压力变化机制的关键一步。本研究通过对咽鼓管扩张性患者的CT扫描建立简化模型。这些模型捕获了管道的关键形态学特征，包括一个封闭鼓室孔的盲端管状结构，一个开放的咽孔，和一个可变形的中心部分。采用粒子图像测速（PIV）技术，在不同的模拟中耳压力条件下，实现了从封闭状态到开放状态过渡过程中腔内流场变化的可视化。观察到以下现象：(1)腔内负压开始时双向抽吸，两侧同时向中心抽吸；(2)不同中耳压力条件下泵送现象的变化；(3)在中耳负压作用下，鼓室孔打开时产生的涡流。这些发现为耳咽管的功能力学提供了新的见解，并为积液性中耳炎（OME）患者行鼓膜切开术并植入套管的手术原理提供了支持证据。

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引用次数: 0

Study of organ of Corti motion in the guinea pig base including differential analysis of internal motion 豚鼠基底Corti运动器官的研究，包括内部运动的差异分析。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-08 DOI: 10.1016/j.heares.2025.109449

Lauren A. Chiriboga , C. Elliott Strimbu , Elika Fallah , Elizabeth S. Olson

The sensation of hearing arises from the interplay of micromechanical motion within the organ of Corti (OC). Optical coherence tomography (OCT) vibrometry has been used to examine the simultaneous motions of OC structures, including the basilar membrane (BM), outer hair cells (OHCs) and reticular lamina (RL), with gerbil and guinea pig (GP) as common animal models. Boosting (motion responses larger than passive motion), and nonlinearity at frequencies below the best frequency (sub-BF) are a robust observation within the gerbil OHC-region. Fallah et al. (2021) compared basal OC mechanics between gerbil and GP and found that GP OC motions at sub-BF frequencies were generally less boosted and showed less nonlinearity than those in gerbil. In the present work, we expand upon the GP measurements by measuring intra-OC motion through both the round window (RW) and a basal cochleostomy in the same experiment. We found substantial differences in the motions when measured through the RW versus the cochleostomy. In the OHC/Deiters Cell(DC) region, sub-BF nonlinearity and boosting were present in measurements through a cochleostomy, but not through the RW. A mild degree of sub-BF nonlinearity was present in the RL region in RW measurements, but not through the cochleostomy. The discussion proposes hypotheses for these differences, including optical angle dependency and mechanical perturbation. Finally, a complex difference analysis was used to extract the internal motion of OC structures riding on the BM motion. The stimulus-level-dependence of the internal OC motions was reduced in the phase responses and increased in the amplitude responses compared to the directly measured OC motion, and irregularities such as nonmonotonic scaling in the measured motion were not present in the extracted internal motion.

听觉是由听觉器官内部的微机械运动相互作用产生的。光学相干断层扫描（OCT）振动测量技术已被用于检测基底膜（BM）、外毛细胞（OHCs）和网状层（RL）等OC结构的同步运动，并以沙鼠和豚鼠（GP）为常见动物模型。在沙鼠ohc区域内，增强（运动响应大于被动运动）和低于最佳频率（次bf）频率的非线性是一个可靠的观察结果。Fallah等人（2021）比较了沙鼠和GP的基本OC力学，发现GP在次bf频率下的OC运动通常比沙鼠的运动增强更少，非线性也更小。在目前的工作中，我们在同一实验中通过圆窗（RW）和基础耳蜗造口术测量耳蜗内运动来扩展GP测量。我们发现通过RW和耳蜗造口术测量的运动有很大的不同。在OHC/ deiter细胞（DC）区域，通过耳蜗造口术测量存在亚bf非线性和增强，但通过RW不存在。在RW测量中，RL区域存在轻度的亚bf非线性，但在耳蜗造口术中没有。讨论提出了这些差异的假设，包括光学角度依赖和机械摄动。最后，采用复差分析方法提取基于基底运动的基底结构的内部运动。与直接测量的OC运动相比，内部OC运动的刺激水平依赖性在相位响应中降低，在幅度响应中增加，并且在提取的内部OC运动中不存在测量运动中的非单调标度等不规则性。

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引用次数: 0

Extended high-frequency hearing sensitivity facilitates predictive speech perception 扩展的高频听力灵敏度有助于预测语音感知。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-15 DOI: 10.1016/j.heares.2025.109453

Tugba Lulaci , Pelle Söderström , Mikael Roll

Speech signal decoding relies on both cognitive performance and the ability to perceive the acoustic signal in sufficient detail. In everyday communication, natural speech is often rapid, spatially and spectrally complex, and accompanied by noise. The brain generates predictions to cope with the complex nature of the auditory signal in speech perception. Anticipatory coarticulation is a natural part of the speech signal. Acoustic traces of upcoming speech sounds provide valuable information that can support auditory prediction, especially when the input is limited or degraded. This study analyzed the relation between individual extended high-frequency hearing threshold differences and word recognition performance in an auditory gating task. Using an adapted gating paradigm with fricative onset (/f/ and /s/) words, we investigated listeners’ extended high-frequency hearing sensitivity in relation to their ability to use early coarticulatory cues predictively for spoken-word recognition. Listeners with better extended high-frequency thresholds were more accurate in predicting the identity of spoken words, using coarticulatory cues as early as 15 ms for words beginning with /s/. In contrast, /f/, which has lower energy in high-frequency energy bands, did not show this pattern. These findings highlight the perceptual role of extended high-frequency hearing in speech perception in natural speech, where input is often limited and variable, showing that extended high-frequency hearing can facilitate predictive processing by enhancing access to subtle early cues in the speech signal.

语音信号解码依赖于认知能力和足够详细地感知声信号的能力。在日常交流中，自然语言往往是快速的，空间和频谱复杂的，并伴随着噪音。大脑产生预测来应对语音感知中听觉信号的复杂性。预期协同发音是语音信号的一个自然组成部分。即将到来的语音的声学痕迹提供了有价值的信息，可以支持听觉预测，特别是当输入有限或退化时。本研究分析了听觉门控任务中个体扩展高频听阈差异与单词识别表现的关系。我们采用带有摩擦音起音（/f/和/s/）单词的适应性门控范式，研究了听者扩展的高频听力灵敏度与他们使用早期协同发音线索预测口语单词识别的能力之间的关系。高频阈值越高的听者在预测口语单词时越准确，对以/s/开头的单词使用协同发音线索的时间早为15毫秒。相比之下，高频能带能量较低的/f/没有表现出这种模式。这些发现强调了扩展高频听力在自然语音感知中的感知作用，其中输入通常是有限和可变的，表明扩展高频听力可以通过增强对语音信号中微妙的早期线索的获取来促进预测处理。

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引用次数: 0

Examining the relationship between difficulties with emotion regulation and misophonia and hyperacusis symptom severity in adults with clinically significant misophonia 临床有明显恐音症的成人情绪调节困难与恐音症及听觉亢进症状严重程度的关系

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-19 DOI: 10.1016/j.heares.2025.109457

Sajana Aryal , Ashley Moskovich , Prashanth Prabhu , M. Zachary Rosenthal

Misophonia is a prevalent and impairing sound intolerance condition that shares symptom overlap and high rates of co-morbidity with hyperacusis. Research demarcating these sound intolerance conditions is critical for the development of accurate diagnostic tools and treatment matching. Previous research suggests difficulties with emotion regulation may be a core feature of misophonia, but its relationship to hyperacusis is unknown. As a first step in exploring whether emotion regulation may be a clinical feature that differentiates misophonia from hyperacusis, the current study examined the relationship between difficulties with emotion regulation and both misophonia and hyperacusis symptom severity in a sample of adults with clinically significant misophonia.

Participants (N=143) completed the Misophonia Questionnaire, the Hyperacusis Questionnaire, and the Difficulties in Emotion Regulation Scale. Stepwise hierarchical regression analyses were conducted to examine whether difficulties with emotion regulation predicted misophonia (Model 1) and hyperacusis (Model 2) symptom severity, after controlling for age and hyperacusis severity or misophonia severity respectively. Partial correlation and Fisher’s Z analyses were subsequently conducted to examine whether domains of emotion regulation were differentially related to symptom severity.

Results indicated that greater difficulties with emotion regulation were significantly associated with misophonia but not hyperacusis severity. Additionally, misophonia symptom severity was specifically related to difficulties with goal-directed behavior, impulse control, access to strategies and nonacceptance. Findings provide preliminary evidence that difficulties with emotion regulation may be a clinical feature that differentiates misophonia from hyperacusis that should be further tested in samples of individuals with hyperacusis without misophonia.

恐音症是一种普遍的、损害性的声音不耐受状况，与听觉亢进有相同的症状重叠和高发病率。划定这些声音不耐受条件的研究对于开发准确的诊断工具和治疗匹配至关重要。先前的研究表明，情绪调节困难可能是恐音症的一个核心特征，但它与听觉亢进的关系尚不清楚。作为探索情绪调节是否可能是区分恐音症和听觉亢进的临床特征的第一步，本研究在临床有明显恐音症的成人样本中检查了情绪调节困难与恐音症和听觉亢进症状严重程度之间的关系。143名被试完成了恐音症问卷、听觉亢进问卷和情绪调节困难量表。采用逐步层次回归分析，在分别控制了年龄和听觉亢进严重程度或恐音严重程度后，检验情绪调节困难是否能预测恐音症（模型1）和听觉亢进（模型2）症状严重程度。随后进行了偏相关分析和Fisher’s Z分析，以检验情绪调节领域是否与症状严重程度存在差异。结果表明，情绪调节困难与恐音症显著相关，但与听觉亢进的严重程度无关。此外，恐音症症状的严重程度与目标导向行为、冲动控制、获取策略和不被接受的困难特别相关。研究结果提供了初步的证据，表明情绪调节困难可能是区分恐音症和听觉亢进的一个临床特征，这应该在有听觉亢进但没有恐音症的个体样本中进一步测试。

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引用次数: 0

METTL3-mediated N6-methyladenosine modification regulates NLRP3 inflammasome activation in chronic suppurative otitis media mettl3介导的n6 -甲基腺苷修饰调节慢性化脓性中耳炎NLRP3炎性体的激活

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-04 DOI: 10.1016/j.heares.2025.109439

Yuanyuan Yang , Jianxin Qiu

Background

Chronic suppurative otitis media (CSOM) is a common inflammatory condition characterized by persistent ear discharge and hearing loss. Recent studies have highlighted the importance of the NLRP3 inflammasome in the pathogenesis of various inflammatory diseases, including CSOM. Here, we investigated the role of METTL3 and N⁶-methyladenosine (m⁶A) modification in the regulation of NLRP3 inflammasome activation in CSOM.

Methods

CSOM model mice were established by intraperitoneally injected with lipopolysaccharide (LPS) and middle ear tissues were collected for analysis. Inflammatory cytokines including TNF-α, IL-1β, IFN-γ, and IL-6 were evaluated, as well as the levels of m⁶A related genes. The potential regulatory effects of METTL3 mediated m⁶A modification of NLRP3 was further studied to explain the inflammatory response in CSOM.

Results

We found that METTL3 overexpression increased the m⁶A level and mRNA stability of NLRP3, leading to enhanced inflammasome activation and production of inflammatory cytokines. Conversely, silencing METTL3 reduced NLRP3 expression and inflammasome activity. Rescue experiments with NLRP3 overexpression confirmed that the effects of METTL3 on inflammation were mediated through NLRP3. Additionally, the NLRP3 inhibitor MCC950 reversed the pro-inflammatory effects of METTL3 overexpression.

Conclusions

Our findings suggest that METTL3-mediated m⁶A modification plays a critical role in NLRP3 inflammasome activation and the inflammatory response in CSOM. Targeting the METTL3/NLRP3 axis may provide a novel therapeutic strategy for the treatment of CSOM.

慢性化脓性中耳炎（CSOM）是一种常见的炎症性疾病，其特征是持续的耳部分泌物和听力丧失。最近的研究强调了NLRP3炎性小体在包括CSOM在内的各种炎症性疾病发病机制中的重要性。在这里，我们研究了METTL3和n6 -甲基腺苷（m6A）修饰在CSOM中调节NLRP3炎性体激活中的作用。方法通过腹腔注射脂多糖（LPS）建立小鼠scsom模型，收集小鼠中耳组织进行分析。评估炎症因子包括TNF-α、IL-1β、IFN-γ和IL-6，以及m6A相关基因的水平。我们进一步研究了METTL3介导的m6A修饰NLRP3的潜在调节作用，以解释CSOM中的炎症反应。结果METTL3过表达增加了NLRP3的m6A水平和mRNA稳定性，导致炎症小体活化和炎症细胞因子的产生增强。相反，沉默METTL3会降低NLRP3的表达和炎症小体的活性。NLRP3过表达的抢救实验证实了METTL3对炎症的作用是通过NLRP3介导的。此外，NLRP3抑制剂MCC950逆转了METTL3过表达的促炎作用。结论mettl3介导的m6A修饰在CSOM NLRP3炎症小体激活和炎症反应中起关键作用。靶向METTL3/NLRP3轴可能为CSOM的治疗提供一种新的治疗策略。

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引用次数: 0

Integrative multi-dataset analysis identifies immune-inflammatory hub genes as diagnostic biomarkers and therapeutic targets for age-related hearing loss 综合多数据集分析确定免疫炎症中心基因作为年龄相关性听力损失的诊断生物标志物和治疗靶点。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-09 DOI: 10.1016/j.heares.2025.109448

Xiaoqin Luo , Wei Yuan , Jun Liu , Chanyuan Zhang , Chao Li , Gang Qin

Age-related hearing loss (ARHL) is a common neurodegenerative disorder in the elderly, but its molecular mechanisms and diagnostic biomarkers remain unclear. Here, by using the GSE49543 dataset (n = 40, Affymetrix microarray) from the Gene Expression Omnibus (GEO) with limma, 17 ARHL-associated differentially expressed genes were identified, which were enriched in immune effector functions and the IL-17 signaling pathway. Weighted gene co-expression network analysis (WGCNA) further revealed that 168 genes were associated with hearing loss (module significance > 0.3). Intersecting DEGs with this module yielded 15 candidates, which were prioritized via protein-protein interaction (PPI) network (STRING) and CytoHubba algorithms to 7 core genes. Machine learning refined these to 5 hub genes: Fcgr3, Cd68, Lgals3, Laptm5, and Mpeg1, showing excellent diagnostic performance. Validation in five independent transcriptomic datasets (GSE49543, GSE6045, GSE153882, GSE154833, and GSE233798) confirmed their upregulation in ARHL samples, and experimental verification via quantitative real-time PCR (qRT-PCR) and immunohistochemistry (IHC) further validated elevated mRNA (FCGR3, CD68, LGALS3, MPEG1) and protein (FCGR3, CD68, LGALS3) levels in aged mouse cochleae. Additionally, single-nucleus RNA sequencing (snRNA-seq) dataset GSE274279 was integrated to validate hub gene expression at single-cell resolution. These findings identify Fcgr3, Cd68, Lgals3, Laptm5, and Mpeg1 as immune-inflammatory hub genes with potential as diagnostic biomarkers and therapeutic targets for ARHL.

年龄相关性听力损失（ARHL）是老年人常见的神经退行性疾病，但其分子机制和诊断生物标志物尚不清楚。本研究利用来自Gene Expression Omnibus （GEO）与limma的GSE49543数据集（n = 40， Affymetrix微阵列），鉴定了17个与arhl相关的差异表达基因，这些基因在免疫效应功能和IL-17信号通路中富集。加权基因共表达网络分析（WGCNA）进一步揭示了168个与听力损失相关的基因（模块显著性> 0.3）。与该模块相交的deg产生15个候选基因，通过蛋白蛋白相互作用（PPI）网络（STRING）和CytoHubba算法对7个核心基因进行优先排序。机器学习将这些基因提炼为5个枢纽基因：Fcgr3、Cd68、Lgals3、Laptm5和Mpeg1，表现出出色的诊断性能。在5个独立的转录组数据集（GSE49543、GSE6045、GSE153882、GSE154833和GSE233798）中验证了它们在ARHL样本中的上调，并通过实时荧光定量PCR （qRT-PCR）和免疫组化（IHC）进一步验证了衰老小鼠耳蜗中mRNA （FCGR3、CD68、LGALS3、MPEG1）和蛋白（FCGR3、CD68、LGALS3）水平升高。此外，还整合了单核RNA测序（snRNA-seq）数据集GSE274279，以验证单细胞分辨率下枢纽基因的表达。这些发现确定Fcgr3、Cd68、Lgals3、Laptm5和Mpeg1是免疫炎症中心基因，具有作为ARHL诊断生物标志物和治疗靶点的潜力。

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引用次数: 0

Suitability of one-axis measurements for quantifying complex cochlear motion under bone conduction stimulation 骨传导刺激下单轴测量量化复杂耳蜗运动的适用性。

IF 2.5 2区医学 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Hearing Research

Pub Date : 2025-12-01 Epub Date: 2025-10-22 DOI: 10.1016/j.heares.2025.109441

Antonio G. Bustos , Ivo Dobrev , Guy Fierens , Christof Röösli

Bone Conduction (BC) refers to the transmission of sound vibrations through the bones of the skull, producing a similar hearing sensation to that of the conventional air-conduction pathway, which transmits sound from the eardrum to the auditory nerve. Clinically, bone conduction hearing aids represent an important resource in the treatment of various middle and outer ear pathologies. Since cochlear motion is considered a good estimation of hearing sensation under BC, accurate motion measurements are essential. Traditionally, single-beam Laser Doppler Vibrometers (LDV) have been used, however, their reliability is limited when the motion deviates from the measurement direction. This study analyses published data of promontory spatial motion, from three-dimensional accelerometers and three-dimensional LDV, to assess the suitability of one-dimensional measurement systems. A literature review of bone conduction studies was conducted, where three-dimensional promontory motion data was analyzed for directional motion influences. The findings presented in this work indicate that motion direction of the ipsilateral promontory is greatly influenced by factors such as distance from stimulation, site and direction of stimulation. Based on the conducted analysis, it was concluded that relying solely on one-dimensional measurements, typically in the ear canal direction, could result in underestimation of the magnitude of the promontory’s motion in the range of 4 to 16 dB at frequencies below 1 kHz, and 1 to 8 dB at higher frequencies, with the largest underestimation occurring when stimulation and measurement are not aligned in the same direction. Hence, clinically relevant metrics, such as transcranial attenuation, are highly dependent on reliable motion measurements. Given the spatial complexity of the promontory motion, three-dimensional measurements are recommended to fully capture skull bone motion and consequently make a better approximation of hearing sensation.

骨传导（Bone Conduction， BC）是指声音振动通过颅骨传递，产生与传统的空气传导途径类似的听觉，后者将声音从鼓膜传递到听神经。在临床上，骨传导助听器是治疗各种中外耳病变的重要资源。由于耳蜗运动被认为是BC下听力感觉的一个很好的估计，准确的运动测量是必不可少的。传统上使用的是单光束激光多普勒测振仪（LDV），但当运动偏离测量方向时，其可靠性受到限制。本研究分析了来自三维加速度计和三维LDV的已发表的海岬空间运动数据，以评估一维测量系统的适用性。我们回顾了骨传导研究的文献，分析了三维海岬运动数据对定向运动的影响。研究结果表明，同侧海岬的运动方向受刺激距离、刺激位置和刺激方向等因素的影响较大。根据所进行的分析，得出的结论是，仅依靠一维测量，通常是在耳道方向，可能导致海岬的运动幅度低估，在1 kHz以下的频率范围内为4至16 dB，在更高的频率范围内为1至8 dB，其中最大的低估发生在刺激和测量不在同一方向时。因此，临床相关指标，如经颅衰减，高度依赖于可靠的运动测量。考虑到海岬运动的空间复杂性，建议采用三维测量来充分捕捉颅骨运动，从而更好地近似听觉。

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引用次数: 0