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Long- and short-term effects of fecal microbiota transplantation on antibiotic resistance genes: results from a randomized placebo-controlled trial 粪便微生物群移植对抗生素耐药基因的长期和短期影响：随机安慰剂对照试验的结果
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-03-13 DOI: 10.1080/19490976.2024.2327442
Armin Rashidi, Maryam Ebadi, Tauseef Ur Rehman, Heba Elhusseini, David Kazadi, Hossam Halaweish, Mohammad H. Khan, Andrea Hoeschen, Qing Cao, Xianghua Luo, Amanda J. Kabage, Sharon Lopez, Shernan G. Holtan, Daniel J. Weisdorf, Chang Liu, Satoshi Ishii, Alexander Khoruts, Christopher Staley
In small series, third-party fecal microbiota transplantation (FMT) has been successful in decolonizing the gut from clinically relevant antibiotic resistance genes (ARGs). Less is known about the ...
在小范围内，第三方粪便微生物群移植（FMT）成功地清除了肠道中与临床相关的抗生素耐药基因（ARGs）。但人们对这种方法的...
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引用次数: 0
Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages 化疗诱导的微生物群通过抑制巨噬细胞的白细胞介素-10而加剧化疗的毒性
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-02-24 DOI: 10.1080/19490976.2024.2319511
Zhen He, Hongyu Xie, Haoyang Xu, Jinjie Wu, Wanyi Zeng, Qilang He, Christian Jobin, Sanqing Jin, Ping Lan
The gut microbiota has been shown to influence the efficacy and toxicity of chemotherapy, thereby affecting treatment outcomes. Understanding the mechanism by which microbiota affects chemotherapeu...
肠道微生物群已被证明会影响化疗的疗效和毒性，从而影响治疗效果。了解微生物群对化疗的影响机制可以帮助我们更好地了解化疗的疗效。
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引用次数: 0
S-amlodipine induces liver inflammation and dysfunction through the alteration of intestinal microbiome in a rat model 在大鼠模型中，S-氨氯地平通过改变肠道微生物组诱发肝脏炎症和功能障碍
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-02-24 DOI: 10.1080/19490976.2024.2316923
Xinxin Liu, Hui Fang, Liuzhu Pan, Peng Zhang, Huai Lin, Huihui Gao, Chaolin Ye, Daqing Mao, Yi Luo
S-amlodipine, a commonly prescribed antihypertensive agent, is widely used in clinical settings to treat hypertension. However, the potential adverse effects of long-term S-amlodipine treatment on ...
S-氨氯地平是一种常用的降压药，被广泛用于临床治疗高血压。然而，长期服用 S-amlodipine 可能会对人体产生不良影响。
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引用次数: 0
The biotherapeutic Clostridium butyricum MIYAIRI 588 strain potentiates enterotropism of Rorγt+Treg and PD-1 blockade efficacy 生物治疗用丁酸梭菌 MIYAIRI 588 菌株可增强 Rorγt+Treg 的肠动力和 PD-1 阻断疗效
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-02-22 DOI: 10.1080/19490976.2024.2315631
Thomas Paz Del Socorro, Kentaro Oka, Olivier Boulard, Motomichi Takahashi, Lionel Franz Poulin, Atsushi Hayashi, Mathias Chamaillard
Immune checkpoint inhibitors (ICI) have been positioned as a standard of care for patients with advanced non-small-cell lung carcinomas (NSCLC). A pilot clinical trial has reflected optimistic asso...
免疫检查点抑制剂（ICI）已被定位为晚期非小细胞肺癌（NSCLC）患者的标准治疗方法。一项试点临床试验显示，免疫检查点抑制剂对晚期非小细胞肺癌（NSCLC）患者的疗效令人乐观。
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引用次数: 0
A universe of human gut-derived bacterial prophages: unveiling the hidden viral players in intestinal microecology 人类肠道细菌噬菌体的宇宙：揭示肠道微生态中隐藏的病毒角色
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-02-01 DOI: 10.1080/19490976.2024.2309684
Zhangming Pei, Yufei Liu, Yutao Chen, Tong Pan, Xihao Sun, Hongchao Wang, R. Paul Ross, Wenwei Lu, Wei Chen
Prophages, which are an existing form of temperate phages that integrate into host genomes, have been found extensively present in diverse bacterial species. The human gut microbiome, characterized...
噬菌体是一种整合到宿主基因组中的现有温带噬菌体形式，已被发现广泛存在于不同的细菌物种中。人类肠道微生物组的特点是...
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引用次数: 0
The contribution of age-related changes in the gut-brain axis to neurological disorders 与年龄有关的肠脑轴变化对神经系统疾病的影响
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-01-18 DOI: 10.1080/19490976.2024.2302801
Romeesa Khan, Claudia M. Di Gesù, Juneyoung Lee, Louise D. McCullough
Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the gut. Recent advances in metagenomics and metabolomics have revealed that the gut microbiota plays a...
数以万亿计的微生物在宿主体内共生，特别是在肠道等粘膜组织中。元基因组学和代谢组学的最新进展揭示了肠道微生物群对人体健康的影响。
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引用次数: 0
Influence of age, socioeconomic status, and location on the infant gut resistome across populations 不同人群的年龄、社会经济地位和地点对婴儿肠道抗性组的影响
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-01-13 DOI: 10.1080/19490976.2023.2297837
Dhrati V. Patangia, Ghjuvan Grimaud, Shaopu Wang, R. Paul Ross, Catherine Stanton
Antibiotic resistance is a growing global concern, with many ecological niches showing a high abundance of antibiotic resistance genes (ARGs), including the human gut. With increasing indications o...
抗生素耐药性是一个日益受到全球关注的问题，许多生态位点都出现了大量的抗生素耐药性基因（ARGs），包括人类肠道。随着越来越多的迹象表明人类肠道中存在抗生素耐药性基因（ARGs），人类肠道中的抗生素耐药性基因也越来越多。
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引用次数: 0
The influence of the gut microbiome on ovarian aging 肠道微生物群对卵巢衰老的影响
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-01-03 DOI: 10.1080/19490976.2023.2295394
Feiling Huang, Ying Cao, Jinghui Liang, Ruiyi Tang, Si Wu, Peng Zhang, Rong Chen
Ovarian aging occurs prior to the aging of other organ systems and acts as the pacemaker of the aging process of multiple organs. As life expectancy has increased, preventing ovarian aging has beco...
卵巢衰老发生在其他器官系统衰老之前，是多个器官衰老过程的起搏器。随着预期寿命的延长，预防卵巢衰老已变得越来越重要。
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引用次数: 0
Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway. 人母乳来源的长双歧杆菌亚种 CCFM1269 通过 PI3K/AKT 通路调节 GH/IGF 轴的骨形成。
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI: 10.1080/19490976.2023.2290344
Mengfan Ding, Bowen Li, Haiqin Chen, Dong Liang, R Paul Ross, Catherine Stanton, Jianxin Zhao, Wei Chen, Bo Yang

Bifidobacterium longum subsp. infantis is a prevalent member of the gut microbiota of breastfed infants. In this study, the effects of human breastmilk-derived B.longum subsp. infantis CCFM1269 on bone formation in developing BALB/c mice were investigated. Newborn female and male mice were assigned to control group (administered saline), CCFM11269 group (administered B. longum subsp. infantis CCFM1269, 1 × 109 CFU/mouse/day) and I5TI group (administered B. longum subsp. infantis I5TI, 1 × 109 CFU/mouse/day) from 1-week-old to 3-, 4- and 5-week old. B. longum subsp. infantis I5TI served as a negative control in this study. The results demonstrated that B. longum subsp. infantis CCFM1269 promoted bone formation in growing mice by modulating the composition of the gut microbiota and metabolites. The expression of genes and proteins in the PI3K/AKT pathway was stimulated by B. longum subsp. infantis CCFM1269 through the GH/IGF-1 axis in growing mice. This finding suggests B. longum subsp. infantis CCFM1269 may be useful for modulating bone metabolism during growth.

长双歧杆菌亚种（Bifidobacterium longum subsp. infantis）是母乳喂养婴儿肠道微生物群中的常见成员。在这项研究中，研究人员调查了母乳中长双歧杆菌亚种 CCFM1269 对发育中的 BALB/c 小鼠骨骼形成的影响。新生雌性和雄性小鼠从 1 周龄到 3、4 和 5 周龄分别被分配到对照组（给予生理盐水）、CCFM11269 组（给予婴儿长球菌亚种 CCFM1269，1 × 109 CFU/小鼠/天）和 I5TI 组（给予婴儿长球菌亚种 I5TI，1 × 109 CFU/小鼠/天）。本研究中的阴性对照为长球菌婴儿亚种 I5TI。结果表明，B. longum subsp. infantis CCFM1269 可通过调节肠道微生物群的组成和代谢物来促进生长期小鼠的骨形成。在生长期小鼠体内，婴儿龙球菌亚种 CCFM1269 通过 GH/IGF-1 轴刺激了 PI3K/AKT 通路中基因和蛋白质的表达。这一发现表明，婴儿龙球菌亚种 CCFM1269 可能有助于调节生长过程中的骨代谢。
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引用次数: 0
Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation. 核酸镰刀菌通过 ADP-庚糖释放和 ALPK1/TIFA 轴激活促进结直肠癌细胞的炎症和抗凋亡反应。
IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gut Microbes
Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI: 10.1080/19490976.2023.2295384
Camille Martin-Gallausiaux, Laurène Salesse, Diego Garcia-Weber, Ludovica Marinelli, Fabienne Beguet-Crespel, Vincent Brochard, Camille Le Gléau, Alexandre Jamet, Joël Doré, Hervé M Blottière, Cécile Arrieumerlou, Nicolas Lapaque

The anaerobic bacterium Fusobacterium nucleatum is significantly associated with human colorectal cancer (CRC) and is considered a significant contributor to the disease. The mechanisms underlying the promotion of intestinal tumor formation by F. nucleatum have only been partially uncovered. Here, we showed that F. nucleatum releases a metabolite into the microenvironment that strongly activates NF-κB in intestinal epithelial cells via the ALPK1/TIFA/TRAF6 pathway. Furthermore, we showed that the released molecule had the biological characteristics of ADP-heptose. We observed that F. nucleatum induction of this pathway increased the expression of the inflammatory cytokine IL-8 and two anti-apoptotic genes known to be implicated in CRC, BIRC3 and TNFAIP3. Finally, it promoted the survival of CRC cells and reduced 5-fluorouracil chemosensitivity in vitro. Taken together, our results emphasize the importance of the ALPK1/TIFA pathway in Fusobacterium induced-CRC pathogenesis, and identify the role of ADP-H in this process.

厌氧菌核酸镰刀菌与人类结直肠癌（CRC）密切相关，被认为是导致该疾病的重要因素。目前仅部分揭示了核酸桿菌促进肠道肿瘤形成的机制。在这里，我们发现 F. nucleatum 会向微环境释放一种代谢物，这种代谢物会通过 ALPK1/TIFA/TRAF6 途径强烈激活肠上皮细胞中的 NF-κB。此外，我们还发现释放的分子具有 ADP-庚糖的生物学特性。我们观察到，F. nucleatum 诱导的这一途径增加了炎性细胞因子 IL-8 和两个已知与 CRC 有关的抗凋亡基因 BIRC3 和 TNFAIP3 的表达。最后，它还促进了 CRC 细胞的存活，降低了体外 5 氟尿嘧啶化疗的敏感性。综上所述，我们的研究结果强调了ALPK1/TIFA通路在镰刀菌诱导的CRC发病机制中的重要性，并确定了ADP-H在这一过程中的作用。
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