Pub Date : 2025-09-01Epub Date: 2025-08-26DOI: 10.1177/11207000251362135
Jonathan Liu, Mohammad Daher, Noah Gilreath, Jared Sain, Nathaniel Smith, Matthew Quinn, Stephen Kayiaros, Valentin Antoci, Eric M Cohen
Introduction: Isolated femoral head and polyethylene liner exchange is commonly performed with varying surgical approaches used for the primary THA (pTHA) and the revision THA (rTHA). The purpose of this study is to investigate the prevalence and postoperative outcomes associated with concordance and discordance in isolated head-liner exchange.
Methods: A retrospective chart review from May 2016 to November 2023 was performed for all patients at 2 institutions who underwent isolated head-liner exchange. 175 patients had minimum 1-year follow-up with complete information regarding surgical approach and outcomes. 175 included were grouped based on their pTHA approach including posterior approach (PA), anterolateral (AL), and direct anterior (DA), and their subsequent rTHA approach. Demographics and postoperative outcomes were compared between groups. Chi-square tests were used to measure associations between surgical approaches and postoperative complications, with a p-value of <0.05 signifying statistical significance.
Results: Our study included 175 patients with isolated head-liner exchange, with a mean age of 68.5 ± 10.4 years. Of the 175 patients, 100 (57.1%) received primary THA via the posterior approach (PA), with 68.0% having concordant revisions. For the anterolateral (AL) and direct anterior (DA) primary approaches, 91.1% and 94.7% of revisions were concordant, respectively. Indication for revision differed by approach, particularly within the PA group, where instability favoured concordant revisions, and metallosis favoured discordant revisions. There was no significant difference in perioperative outcomes between concordant and discordant approaches, except the concordant group had more EBL, higher rates of transfusions, reoperations, and discharge to skilled nursing facilities (SNF).
Conclusions: In pTHA cohort, patients with PA approach were more likely to undergo head-liner exchange with a discordant approach via DA or AL. As no significant associations were found in any combination of discordant approaches with postoperative complications, surgeons should choose their head-liner approach without significant concern for discordance.
{"title":"Impact of primary surgical approach on revision approach for isolated head-liner exchange in total hip arthroplasty.","authors":"Jonathan Liu, Mohammad Daher, Noah Gilreath, Jared Sain, Nathaniel Smith, Matthew Quinn, Stephen Kayiaros, Valentin Antoci, Eric M Cohen","doi":"10.1177/11207000251362135","DOIUrl":"10.1177/11207000251362135","url":null,"abstract":"<p><strong>Introduction: </strong>Isolated femoral head and polyethylene liner exchange is commonly performed with varying surgical approaches used for the primary THA (pTHA) and the revision THA (rTHA). The purpose of this study is to investigate the prevalence and postoperative outcomes associated with concordance and discordance in isolated head-liner exchange.</p><p><strong>Methods: </strong>A retrospective chart review from May 2016 to November 2023 was performed for all patients at 2 institutions who underwent isolated head-liner exchange. 175 patients had minimum 1-year follow-up with complete information regarding surgical approach and outcomes. 175 included were grouped based on their pTHA approach including posterior approach (PA), anterolateral (AL), and direct anterior (DA), and their subsequent rTHA approach. Demographics and postoperative outcomes were compared between groups. Chi-square tests were used to measure associations between surgical approaches and postoperative complications, with a <i>p</i>-value of <0.05 signifying statistical significance.</p><p><strong>Results: </strong>Our study included 175 patients with isolated head-liner exchange, with a mean age of 68.5 ± 10.4 years. Of the 175 patients, 100 (57.1%) received primary THA via the posterior approach (PA), with 68.0% having concordant revisions. For the anterolateral (AL) and direct anterior (DA) primary approaches, 91.1% and 94.7% of revisions were concordant, respectively. Indication for revision differed by approach, particularly within the PA group, where instability favoured concordant revisions, and metallosis favoured discordant revisions. There was no significant difference in perioperative outcomes between concordant and discordant approaches, except the concordant group had more EBL, higher rates of transfusions, reoperations, and discharge to skilled nursing facilities (SNF).</p><p><strong>Conclusions: </strong>In pTHA cohort, patients with PA approach were more likely to undergo head-liner exchange with a discordant approach via DA or AL. As no significant associations were found in any combination of discordant approaches with postoperative complications, surgeons should choose their head-liner approach without significant concern for discordance.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"517-522"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01Epub Date: 2024-10-07DOI: 10.1177/11207000241282398
Rashid M Tikhilov, Nikolai N Efimov, Igor I Shubnyakov, Maksim Y Goncharov, Dmitrii V Stafeev, Vitalii V Karelkin
Background: Constrained liners (CLs) have been used in revision total hip arthroplasty (rTHA) with varying results. Relatively few studies have identified specific risk factors for failure. This study aimed to assess implant survivorship and complication rates, identify risk factors for constraint-related complications, and assess the effect of multiple factors present in a single case.
Methods: We conducted a retrospective analysis of 101 rTHAs for various aseptic indications and as second-stage procedures for periprosthetic joint infection (PJI) utilising 2 models of conventional single-articulation CLs. We excluded 8 cases in which the liners were removed early due to PJI and assessed the risk factors for constraint-related complications in the remaining 93 cases. The mean follow-up duration for complication-free cases was 6.5 years (range 4.7-10.5 years).
Results: The incidences of dislocation of a prosthetic head and loosening of the acetabular component were 19.8% and 5.0%, respectively. We also observed 8 cases where the locking ring of the liner was dislodged without dislocation (1 case required re-revision). The presence of factors related to impingement (cup retention, smaller internal diameter CLs, signs of probable impingement from the femoral side) was associated with higher rates of constraint-related complications. The presence of factors related to soft-tissue stabilisers did not increase the rate of complications. The simultaneous presence of multiple impingement-related risk factors resulted in worse outcomes.
Conclusions: CLs may be less effective for treating or preventing instability related to impingement. CLs should be used with caution or avoided when multiple impingement-related risk factors are present.
{"title":"Conventional single articulation constrained liners in revision hip arthroplasty: risk factors for failure and their combinations.","authors":"Rashid M Tikhilov, Nikolai N Efimov, Igor I Shubnyakov, Maksim Y Goncharov, Dmitrii V Stafeev, Vitalii V Karelkin","doi":"10.1177/11207000241282398","DOIUrl":"10.1177/11207000241282398","url":null,"abstract":"<p><strong>Background: </strong>Constrained liners (CLs) have been used in revision total hip arthroplasty (rTHA) with varying results. Relatively few studies have identified specific risk factors for failure. This study aimed to assess implant survivorship and complication rates, identify risk factors for constraint-related complications, and assess the effect of multiple factors present in a single case.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 101 rTHAs for various aseptic indications and as second-stage procedures for periprosthetic joint infection (PJI) utilising 2 models of conventional single-articulation CLs. We excluded 8 cases in which the liners were removed early due to PJI and assessed the risk factors for constraint-related complications in the remaining 93 cases. The mean follow-up duration for complication-free cases was 6.5 years (range 4.7-10.5 years).</p><p><strong>Results: </strong>The incidences of dislocation of a prosthetic head and loosening of the acetabular component were 19.8% and 5.0%, respectively. We also observed 8 cases where the locking ring of the liner was dislodged without dislocation (1 case required re-revision). The presence of factors related to impingement (cup retention, smaller internal diameter CLs, signs of probable impingement from the femoral side) was associated with higher rates of constraint-related complications. The presence of factors related to soft-tissue stabilisers did not increase the rate of complications. The simultaneous presence of multiple impingement-related risk factors resulted in worse outcomes.</p><p><strong>Conclusions: </strong>CLs may be less effective for treating or preventing instability related to impingement. CLs should be used with caution or avoided when multiple impingement-related risk factors are present.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"437-444"},"PeriodicalIF":1.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-08-18DOI: 10.1177/11207000251365201
Roderick J M Vossen, Gaby V Ten Noever de Brauw, Jore H Willems, Rienk Eshuis, Inger N Sierevelt, Anneke Spekenbrink-Spooren, Hendrik A Zuiderbaan
Background: The association between primary total hip arthroplasty (THA) approaches and short-term mortality rates remained unexplored. This study aimed to compare short-term mortality rates between the direct anterior (DAA), posterolateral (PL), anterolateral (AL) and direct lateral (DL) approaches and determine associated factors.
Methods: A registry study was conducted using data from 2007 to 2023 of the Dutch Arthroplasty Register. 30- and 90-day mortality were compared between approaches using the chi-square test and the logistic regression analysis to adjust for confounders (age, sex, patient's physical status [ASA] classification, fixation method, body mass index [BMI] and smoking status). Multivariate regression models were used to determine factors associated with short-term mortality. Sensitivity analyses for time periods (2007-2012, 2013-2017, 2018-2023) were performed.
Results: The study comprised 379,108 patients (mean age 69.9 ± 9.5, male 33.8%). The AL, PL and DL approaches demonstrated a significantly larger likelihood for 30-day mortality compared to the DAA after adjusting for confounders (DAA: reference; AL: OR 2.32 [1.52-3.57], p < 0.001; PL: OR 1.79 [1.36-2.36], p < 0.001; DL: OR 2.78 [1.69-4.57], p < 0 .001). In ASA I-II patients, likelihood for 90-day mortality for the AL, PL and DL approaches was significantly higher than the DAA approach (DAA: reference; AL: OR 2.293, p < 0.001; PL: OR 1.963, p < 0.001; DL: OR 2.016, p < 0.001). In ASA III-IV patients, differences were not significant, except when comparing the DL to the DAA approach (OR 1.484, p = 0.011). Increased age, male sex, surgical approach and cemented fixation were significantly associated with 30- and 90-day mortality.
Conclusions: Findings were suggestive that the DAA provides a reduced likelihood for short-term mortality compared to the PL, AL and DL, after adjusting for confounding factors. Differences in mortality rate were more substantial in healthy patients and remained similar irrespective of time periods. Increased age, male sex, surgical approach, and cemented fixation increased likelihood on short-term mortality.
背景:原发性全髋关节置换术(THA)入路与短期死亡率之间的关系尚不清楚。本研究旨在比较直接前路(DAA)、后外侧(PL)、前外侧(AL)和直接外侧(DL)入路的短期死亡率,并确定相关因素。方法:采用2007年至2023年荷兰关节成形术登记的数据进行登记研究,采用卡方检验和logistic回归分析比较两种方法的30天和90天死亡率,以调整混杂因素(年龄、性别、患者身体状况[ASA]分类、固定方法、体重指数[BMI]和吸烟状况)。采用多元回归模型确定与短期死亡率相关的因素。对时间段(2007-2012年、2013-2017年、2018-2023年)进行敏感性分析。结果:共纳入379108例患者,平均年龄69.9±9.5岁,男性33.8%。调整混杂因素后,AL、PL和DL方法与DAA方法相比,显示出显著更高的30天死亡率(DAA:参考;AL: OR 2.32 [1.52-3.57], pp pp pp = 0.011)。年龄、男性、手术入路和骨水泥固定与30天和90天死亡率显著相关。结论:研究结果提示,在调整混杂因素后,与PL、AL和DL相比,DAA提供了降低短期死亡率的可能性。健康患者的死亡率差异更大,并且在任何时期都保持相似。年龄、男性、手术入路和骨水泥固定增加了短期死亡率的可能性。
{"title":"The direct anterior approach in total hip arthroplasty may be associated with lower short-term mortality compared to various other approaches: a Dutch arthroplasty register study comprising 379,108 procedures.","authors":"Roderick J M Vossen, Gaby V Ten Noever de Brauw, Jore H Willems, Rienk Eshuis, Inger N Sierevelt, Anneke Spekenbrink-Spooren, Hendrik A Zuiderbaan","doi":"10.1177/11207000251365201","DOIUrl":"10.1177/11207000251365201","url":null,"abstract":"<p><strong>Background: </strong>The association between primary total hip arthroplasty (THA) approaches and short-term mortality rates remained unexplored. This study aimed to compare short-term mortality rates between the direct anterior (DAA), posterolateral (PL), anterolateral (AL) and direct lateral (DL) approaches and determine associated factors.</p><p><strong>Methods: </strong>A registry study was conducted using data from 2007 to 2023 of the Dutch Arthroplasty Register. 30- and 90-day mortality were compared between approaches using the chi-square test and the logistic regression analysis to adjust for confounders (age, sex, patient's physical status [ASA] classification, fixation method, body mass index [BMI] and smoking status). Multivariate regression models were used to determine factors associated with short-term mortality. Sensitivity analyses for time periods (2007-2012, 2013-2017, 2018-2023) were performed.</p><p><strong>Results: </strong>The study comprised 379,108 patients (mean age 69.9 ± 9.5, male 33.8%). The AL, PL and DL approaches demonstrated a significantly larger likelihood for 30-day mortality compared to the DAA after adjusting for confounders (DAA: reference; AL: OR 2.32 [1.52-3.57], <i>p</i> < 0.001; PL: OR 1.79 [1.36-2.36], <i>p</i> < 0.001; DL: OR 2.78 [1.69-4.57], <i>p</i> < 0 .001). In ASA I-II patients, likelihood for 90-day mortality for the AL, PL and DL approaches was significantly higher than the DAA approach (DAA: reference; AL: OR 2.293, <i>p</i> < 0.001; PL: OR 1.963, <i>p</i> < 0.001; DL: OR 2.016, <i>p</i> < 0.001). In ASA III-IV patients, differences were not significant, except when comparing the DL to the DAA approach (OR 1.484, <i>p</i> = 0.011). Increased age, male sex, surgical approach and cemented fixation were significantly associated with 30- and 90-day mortality.</p><p><strong>Conclusions: </strong>Findings were suggestive that the DAA provides a reduced likelihood for short-term mortality compared to the PL, AL and DL, after adjusting for confounding factors. Differences in mortality rate were more substantial in healthy patients and remained similar irrespective of time periods. Increased age, male sex, surgical approach, and cemented fixation increased likelihood on short-term mortality.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"11207000251365201"},"PeriodicalIF":1.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2020-07-07DOI: 10.1177/1120700020939075
Wouter H Mallee, Anne E Wijsbek, Matthias U Schafroth, Julius Wolkenfelt, Dominique C Baas, Ton M J S Vervest
Objective: Does the use of staples or sutures for wound closure have a lower surgical site infection rate in patients receiving primary total hip arthroplasty (THA)?
Methods: 535 patients undergoing THA were included and randomised into 2 groups: 268 wounds were closed with staples, and 267 with sutures. Primary outcome was surgical site infection (SSI). Secondary outcomes were prosthetic joint infection (PJI), other wound complications (dehiscence, necrosis and prolonged drainage) and duration of admittance. Follow-up occurred at 2, 6, and 12 weeks, and at 1 year.
Results: There were no significant demographic differences between the 2 groups. SSI occurred more frequently when wounds were closed with staples (4% compared to 1% with sutures; OR 2.8; CI, 0.885-0.952; p = 0.057). SSI was treated with oral antibiotics. The staples group showed significantly more wound complications (17% compared to 5%; OR 3.943, CI 2.073-7.498; p = 0.000). Wound discharge was significantly prolonged in the staples group (n = 40, compared to n = 12 in the sutures group; OR 3.728; CI, 1.909-7.281; p = 0.000). There was no significant difference in PJI (p = 0.364).
Conclusions: In this large RCT comparing staples with sutures after THA, the use of staples is associated with a nearly 3 times greater risk of SSI (OR 2.8; p = 0.057). Staples significantly prolong wound discharge. The use of sutures for wound closure after THA is advised.Trial registration: Staples Or Sutures trial (S.O.S. trial) http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3946, NTR3946.
{"title":"Wound complications after total hip arthroplasty: a prospective, randomised controlled trial comparing staples with sutures.","authors":"Wouter H Mallee, Anne E Wijsbek, Matthias U Schafroth, Julius Wolkenfelt, Dominique C Baas, Ton M J S Vervest","doi":"10.1177/1120700020939075","DOIUrl":"10.1177/1120700020939075","url":null,"abstract":"<p><strong>Objective: </strong>Does the use of staples or sutures for wound closure have a lower surgical site infection rate in patients receiving primary total hip arthroplasty (THA)?</p><p><strong>Design: </strong>Prospective, randomised controlled multicentre trial.</p><p><strong>Methods: </strong>535 patients undergoing THA were included and randomised into 2 groups: 268 wounds were closed with staples, and 267 with sutures. Primary outcome was surgical site infection (SSI). Secondary outcomes were prosthetic joint infection (PJI), other wound complications (dehiscence, necrosis and prolonged drainage) and duration of admittance. Follow-up occurred at 2, 6, and 12 weeks, and at 1 year.</p><p><strong>Results: </strong>There were no significant demographic differences between the 2 groups. SSI occurred more frequently when wounds were closed with staples (4% compared to 1% with sutures; OR 2.8; CI, 0.885-0.952; <i>p</i> = 0.057). SSI was treated with oral antibiotics. The staples group showed significantly more wound complications (17% compared to 5%; OR 3.943, CI 2.073-7.498; <i>p</i> = 0.000). Wound discharge was significantly prolonged in the staples group (<i>n</i> = 40, compared to <i>n</i> = 12 in the sutures group; OR 3.728; CI, 1.909-7.281; <i>p</i> = 0.000). There was no significant difference in PJI (<i>p</i> = 0.364).</p><p><strong>Conclusions: </strong>In this large RCT comparing staples with sutures after THA, the use of staples is associated with a nearly 3 times greater risk of SSI (OR 2.8; <i>p</i> = 0.057). Staples significantly prolong wound discharge. The use of sutures for wound closure after THA is advised.<b>Trial registration:</b> Staples Or Sutures trial (S.O.S. trial) http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3946, NTR3946.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"326-331"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-06-08DOI: 10.1177/11207000251345995
James E Miller, Ibrahim Inzarul Haq, Elizabeth Hedge, Paul Saunders, Muhamed M Farhan-Alanie, Siew Wan Hee, Ajay Chourasia, Prasad Rao, Steve K Young
Background: The presence of radiolucent lines (RLLs) around total hip replacement (THR) stems correlates with stem failure. However, the zone this occurs in is significant. The widely adopted Gruen Zone classification has disadvantages and is unlikely to be reflective of uncemented biomechanics. We propose a simpler system for describing these changes and introduce its relevance clinically.
Methods: In a single-centre retrospective study CORAIL THR stems implanted between 2010 and 2013 were analysed. On postoperative radiographs 2 parallel "SKY" lines divided the stem bone interface into 3 zones A, B and C. 1 year and 5 years postoperative radiographs were reviewed by 5 surgeons for the presence and location of RLLs. The revision rates of the UK's National Joint Registry were correlated with the presence of RLLs.
Results: 1113 stems were included.331 (29.7%) had RLLs, 273 (24.5%) in zone A only, 50 (4.5%) in zones A and B and 8 (0.7%) in all 3 zones A, B and C. In absence of RRLs in zone A, no RLLs were identified in the other zones. 73% RRLs appeared in the first postoperative year, the remaining at 5 years follow-up.1.8% (20 of 1113) stems were revised. The revision rate for stems with RLLs in zone A alone was 2.9%, with RLLs in zone A and B it was 12% and with RLLs in all 3 zones it was 12.5%.The odds of revision were 4.7 times higher (p = 0.007) with RLLs in Zone A and 6.6 times higher (p < 0.001) with RLLs in Zones B and C compared to those without.
Conclusions: The SKY lines can be used to classify RLLs and predict the risk of revision for the CORAIL stem. Stems with RLLs progressing beyond the first SKY line from zone A into Zone B-C should be considered higher risk for revision and hence followed-up closely for signs of failure. Absence of RLLs or RLLs in Zone A only can be discharged to patient-initiated follow-up.
{"title":"The SKY is the limit - a novel system for interpreting radiolucent lines around CORAIL uncemented total hip arthroplasty stems: a proof-of-concept study.","authors":"James E Miller, Ibrahim Inzarul Haq, Elizabeth Hedge, Paul Saunders, Muhamed M Farhan-Alanie, Siew Wan Hee, Ajay Chourasia, Prasad Rao, Steve K Young","doi":"10.1177/11207000251345995","DOIUrl":"10.1177/11207000251345995","url":null,"abstract":"<p><strong>Background: </strong>The presence of radiolucent lines (RLLs) around total hip replacement (THR) stems correlates with stem failure. However, the zone this occurs in is significant. The widely adopted Gruen Zone classification has disadvantages and is unlikely to be reflective of uncemented biomechanics. We propose a simpler system for describing these changes and introduce its relevance clinically.</p><p><strong>Methods: </strong>In a single-centre retrospective study CORAIL THR stems implanted between 2010 and 2013 were analysed. On postoperative radiographs 2 parallel \"SKY\" lines divided the stem bone interface into 3 zones A, B and C. 1 year and 5 years postoperative radiographs were reviewed by 5 surgeons for the presence and location of RLLs. The revision rates of the UK's National Joint Registry were correlated with the presence of RLLs.</p><p><strong>Results: </strong>1113 stems were included.331 (29.7%) had RLLs, 273 (24.5%) in zone A only, 50 (4.5%) in zones A and B and 8 (0.7%) in all 3 zones A, B and C. In absence of RRLs in zone A, no RLLs were identified in the other zones. 73% RRLs appeared in the first postoperative year, the remaining at 5 years follow-up.1.8% (20 of 1113) stems were revised. The revision rate for stems with RLLs in zone A alone was 2.9%, with RLLs in zone A and B it was 12% and with RLLs in all 3 zones it was 12.5%.The odds of revision were 4.7 times higher (<i>p =</i> 0.007) with RLLs in Zone A and 6.6 times higher (<i>p <</i> 0.001) with RLLs in Zones B and C compared to those without.</p><p><strong>Conclusions: </strong>The SKY lines can be used to classify RLLs and predict the risk of revision for the CORAIL stem. Stems with RLLs progressing beyond the first SKY line from zone A into Zone B-C should be considered higher risk for revision and hence followed-up closely for signs of failure. Absence of RLLs or RLLs in Zone A only can be discharged to patient-initiated follow-up.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"344-352"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Studies on short-stem total hip arthroplasty (THA) in young patients with developmental dysplasia of the hip (DDH) are limited, with no studies on long-term outcomes. Our study aimed to investigate whether the Mayo conservative hip stem demonstrates favourable mid- to long-term outcomes in these patients.
Methods: This retrospective study included 42 patients (50 joints) with DDH aged <55 years who underwent THA using the Mayo conservative hip stem and excluded those with a follow-up period <5 years. Radiographic evaluation involved comparison of the immediate postoperative anteroposterior images with those at the final follow-up. Clinical evaluations utilised the Japanese Orthopaedic Association (JOA) hip score and major postoperative complications, including revision surgery.
Results: The mean age of the patients was 48.8 years, with a median follow-up of 11 years. According to the Crowe classification, 35, 11, and 4 cases were classified as Types I, II, and III, respectively. According to the Dorr classification, 29 and 21 cases were classified as Types A and B, respectively. Radiographically, spot welds were observed in 98% of joints in zones 2 or 6, whereas stress shielding was evident in 94% (zone 1) and 54% (zone 7) of the joints. Stem sinking ⩾3 mm was observed in 2 joints. No periprosthetic femoral fractures, dislocations, or infections were observed.
Conclusions: The Mayo conservative stem in young patients with DDH resulted in favourable mid- to long-term outcomes, including stability and bone preservation. The stem is an effective treatment strategy for these patients.
{"title":"Mayo conservative hip stem for proximal femoral bone preservation in developmental dysplasia of the hip in young patients: a median follow-up of more than 10 years.","authors":"Masanori Nishi, Takashi Atsumi, Yasushi Yoshikawa, Ryosuke Nakanishi, Minoru Watanabe, Tsubasa Ishikawa, Yuki Usui, Tokito Tatsuo, Yoshifumi Kudo","doi":"10.1177/11207000251338196","DOIUrl":"10.1177/11207000251338196","url":null,"abstract":"<p><strong>Purpose: </strong>Studies on short-stem total hip arthroplasty (THA) in young patients with developmental dysplasia of the hip (DDH) are limited, with no studies on long-term outcomes. Our study aimed to investigate whether the Mayo conservative hip stem demonstrates favourable mid- to long-term outcomes in these patients.</p><p><strong>Methods: </strong>This retrospective study included 42 patients (50 joints) with DDH aged <55 years who underwent THA using the Mayo conservative hip stem and excluded those with a follow-up period <5 years. Radiographic evaluation involved comparison of the immediate postoperative anteroposterior images with those at the final follow-up. Clinical evaluations utilised the Japanese Orthopaedic Association (JOA) hip score and major postoperative complications, including revision surgery.</p><p><strong>Results: </strong>The mean age of the patients was 48.8 years, with a median follow-up of 11 years. According to the Crowe classification, 35, 11, and 4 cases were classified as Types I, II, and III, respectively. According to the Dorr classification, 29 and 21 cases were classified as Types A and B, respectively. Radiographically, spot welds were observed in 98% of joints in zones 2 or 6, whereas stress shielding was evident in 94% (zone 1) and 54% (zone 7) of the joints. Stem sinking ⩾3 mm was observed in 2 joints. No periprosthetic femoral fractures, dislocations, or infections were observed.</p><p><strong>Conclusions: </strong>The Mayo conservative stem in young patients with DDH resulted in favourable mid- to long-term outcomes, including stability and bone preservation. The stem is an effective treatment strategy for these patients.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"377-383"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-05-15DOI: 10.1177/11207000251337403
Seth Spicer, Hanna Brancaccio, Ashley Sundin, Jamie Bono, John DesRochers, Brandon Goodwin, Nicholas Averell, Seungkyu Park, Alexandra Goodwin, William DiCiurcio, Richard Jermyn
Background: The objective of this study was to determine the effect of bone marrow aspirate concentrate (BMAC) on long-term patient outcomes when used as an adjuvant to acetabular repair of the labrum.
Methods: A systematic review and meta-analysis were completed following PRISMA 2020 guidelines. Included in the analysis were controlled studies which assessed functional outcomes via the International Hip Outcome Tool-33 (iHOT-33) 12 or 24 months after acetabular repair with BMAC adjunct. 4 studies totaling 315 participants were analysed.
Results: Pooled effect sizes for iHOT-33 scores were not significantly different between control and treatment groups at 12 (p= 0.14, Cohen's D ≏ 0.79) or 24 months (p= 0.30, Cohen's D ≏ 0.56).
Conclusions: Non-significant trends in favour of BMAC augmentation were found in this study. However, the trends reported are promising and warrant further investigation with further randomised controlled trials.
{"title":"Bone marrow aspirate concentrate adjunct for acetabular labral tear repair: a systematic review and meta-analysis.","authors":"Seth Spicer, Hanna Brancaccio, Ashley Sundin, Jamie Bono, John DesRochers, Brandon Goodwin, Nicholas Averell, Seungkyu Park, Alexandra Goodwin, William DiCiurcio, Richard Jermyn","doi":"10.1177/11207000251337403","DOIUrl":"10.1177/11207000251337403","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to determine the effect of bone marrow aspirate concentrate (BMAC) on long-term patient outcomes when used as an adjuvant to acetabular repair of the labrum.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were completed following PRISMA 2020 guidelines. Included in the analysis were controlled studies which assessed functional outcomes via the International Hip Outcome Tool-33 (iHOT-33) 12 or 24 months after acetabular repair with BMAC adjunct. 4 studies totaling 315 participants were analysed.</p><p><strong>Results: </strong>Pooled effect sizes for iHOT-33 scores were not significantly different between control and treatment groups at 12 (<i>p</i> <i>=</i> 0.14, Cohen's D ≏ 0.79) or 24 months (<i>p</i> <i>=</i> 0.30, Cohen's D ≏ 0.56).</p><p><strong>Conclusions: </strong>Non-significant trends in favour of BMAC augmentation were found in this study. However, the trends reported are promising and warrant further investigation with further randomised controlled trials.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"392-401"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-05-04DOI: 10.1177/11207000251335223
Pablo A Slullitel, Marcos Latorre, Francisco Principe, Felipe Patterson, Gerardo Zanotti, Fernando Comba, Martin A Buttaro
Background: To report the association between os acetabuli and relevant radiologic measurements in a series of surgically treated hip preservation patients.
Methods: We retrospectively reviewed 654 hips who underwent preservation surgery between 2012 and 2019, identifying 50 cases with os acetabuli (7.64%). We included 300 hips (277 patients) with radiographs and CT-scans obtained during preoperative assessment, after which the cohort was divided into two groups (with and without os acetabuli). Mean age of the study population was 35 (interquartile range [IQR] 28-42) years old, with 192 (62%) being males. 2 observers measured demographic and radiologic variables. A mixed-effects logistic regression tested the ability of radiologic measurements to predict the presence of os acetabuli.
Results: No between-group differences were found in terms of sex (156/250 vs. 36/50 males, p = 0.197), alpha angle (64 ± 13° vs. 65 ± 14°, p = 0.372), Tönnis angle (8 ± 7° vs. 7 ± 7°, p = 0.152), neck-shaft angle (132 ± 6° vs. 131 ± 5°, p = 0.199) and CT-acetabular version (16 ± 7° vs. 15 ± 6°, p = 0.221). Significant differences were found in terms of age (34 ± 9 vs. 39 ± 7 years, p = 0.002), lateral centre-edge angle (LCEA) (31 ± 9° vs. 34 ± 7°, p = 0.045), anterior wall index (AWI) (0.45 [IQR 0.37-0.54] vs 0.5 [IQR 0.39-0.6], p = 0.046), CT-femoral version (17 ± 5° vs. 8 ± 4°, p < 0.001), cross-over sign (96/250 vs. 28/50, p = 0.032) and baseline diagnosis (184/250 vs. 44/50 FAIs, p = 0.043), with the os acetabuli-group being older, with more FAI diagnosis/cross-over sign, and with higher LCEA, higher AWI, and a lower femoral version. After adjusting for confounders, only CT-femoral version (odds ratio 0.32; 95% CI. 0.14-0.73, p < 0.007) was associated with presence of os acetabuli.
Conclusions: Presence of acetabular rim fragments was significantly associated with a lower femoral version. Above 20° of femoral version, the likelihood of os acetabuli was almost zero. Treatment of os acetabuli (i.e., fixation vs. removal) should be adjusted for the underlying diagnosis.
{"title":"Os acetabuli is an indirect radiographic sign of femoral retroversion.","authors":"Pablo A Slullitel, Marcos Latorre, Francisco Principe, Felipe Patterson, Gerardo Zanotti, Fernando Comba, Martin A Buttaro","doi":"10.1177/11207000251335223","DOIUrl":"10.1177/11207000251335223","url":null,"abstract":"<p><strong>Background: </strong>To report the association between os acetabuli and relevant radiologic measurements in a series of surgically treated hip preservation patients.</p><p><strong>Methods: </strong>We retrospectively reviewed 654 hips who underwent preservation surgery between 2012 and 2019, identifying 50 cases with os acetabuli (7.64%). We included 300 hips (277 patients) with radiographs and CT-scans obtained during preoperative assessment, after which the cohort was divided into two groups (with and without os acetabuli). Mean age of the study population was 35 (interquartile range [IQR] 28-42) years old, with 192 (62%) being males. 2 observers measured demographic and radiologic variables. A mixed-effects logistic regression tested the ability of radiologic measurements to predict the presence of os acetabuli.</p><p><strong>Results: </strong>No between-group differences were found in terms of sex (156/250 vs. 36/50 males, <i>p =</i> 0.197), alpha angle (64 ± 13° vs. 65 ± 14°, <i>p =</i> 0.372), Tönnis angle (8 ± 7° vs. 7 ± 7°, <i>p =</i> 0.152), neck-shaft angle (132 ± 6° vs. 131 ± 5°, <i>p =</i> 0.199) and CT-acetabular version (16 ± 7° vs. 15 ± 6°, <i>p =</i> 0.221). Significant differences were found in terms of age (34 ± 9 vs. 39 ± 7 years, <i>p =</i> 0.002), lateral centre-edge angle (LCEA) (31 ± 9° vs. 34 ± 7°, <i>p =</i> 0.045), anterior wall index (AWI) (0.45 [IQR 0.37-0.54] vs 0.5 [IQR 0.39-0.6], <i>p =</i> 0.046), CT-femoral version (17 ± 5° vs. 8 ± 4°, <i>p <</i> 0.001), cross-over sign (96/250 vs. 28/50, <i>p =</i> 0.032) and baseline diagnosis (184/250 vs. 44/50 FAIs, <i>p =</i> 0.043), with the os acetabuli-group being older, with more FAI diagnosis/cross-over sign, and with higher LCEA, higher AWI, and a lower femoral version. After adjusting for confounders, only CT-femoral version (odds ratio 0.32; 95% CI. 0.14-0.73, <i>p <</i> 0.007) was associated with presence of os acetabuli.</p><p><strong>Conclusions: </strong>Presence of acetabular rim fragments was significantly associated with a lower femoral version. Above 20° of femoral version, the likelihood of os acetabuli was almost zero. Treatment of os acetabuli (i.e., fixation vs. removal) should be adjusted for the underlying diagnosis.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"384-391"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-01-20DOI: 10.1177/11207000241312385
Jeffrey A O'Donnell, Daniel B Buchalter, Tracy M Borsinger, Sonia K Chandi, Colin C Neitzke, Geoffrey H Westrich, Elizabeth B Gausden
Introduction: Total hip arthroplasty (THA) is widely used for active, elderly patients with femoral neck fractures (FNF). Compared to THA for osteoarthritis, THA for FNF is associated with a higher incidence of dislocation and reoperation. Robotic assistance may improve component positioning and leg-length restoration in THA, but its use in FNF has not been described. The objective of this study was to assess the feasibility and perioperative outcomes of robotic-assisted THA (rTHA) for FNF.
Methods: A retrospective review identified 93 patients undergoing 94 THAs for FNF from 2016 to 2023. 18 patients treated with MAKOplasty rTHA were compared to 76 non-rTHA. There were 69 (73%) women, the mean age was 71 years, and the mean follow-up was 3 years.
Results: There was no significant difference in operative time between rTHA and non-rTHA cohorts (100 vs. 108 minutes, p = 0.19), and sub-analysis of acute FNFs (< 6 weeks), showed no difference in the meantime from presentation to surgery (18 vs. 25 hours, p = 0.24). There was no significant difference in mean leg-length discrepancy (LLD) (p = 0.19), number of outliers for acetabular anteversion (p = 0.80), or inclination (p = 0.55). There were no postoperative dislocations or reoperations in the rTHA cohort, compared to 4 dislocations (5%) and 6 reoperations (8%) in the non-rTHA cohort (p = 1.00 and 0.59, respectively).
Conclusions: In this series of THA for FNF, robotic assistance did not significantly delay the time to surgery or increase the operative time compared to non-rTHA. At a mean follow-up of 3 years, there were no postoperative dislocations or reoperations in the rTHA cohort.
导语:全髋关节置换术(THA)被广泛应用于活跃的老年股骨颈骨折(FNF)患者。与骨关节炎的全髋关节置换术相比,FNF的全髋关节置换术与更高的脱位和再手术发生率相关。机器人辅助可以改善THA中的部件定位和腿长恢复,但其在FNF中的应用尚未描述。本研究的目的是评估机器人辅助THA (rTHA)治疗FNF的可行性和围手术期结果。方法:回顾性分析2016年至2023年93例FNF患者接受94次tha手术。18例接受MAKOplasty rTHA治疗的患者与76例非rTHA治疗的患者进行了比较。69例(73%)女性,平均年龄71岁,平均随访3年。结果:rTHA组和非rTHA组的手术时间无显著差异(100 vs 108分钟,p = 0.19),急性fnf(< 6周)的亚分析显示,从出现到手术的时间无显著差异(18 vs 25小时,p = 0.24)。平均腿长差异(LLD) (p = 0.19)、髋臼前倾异常数(p = 0.80)和倾斜异常数(p = 0.55)无显著差异。rTHA组无术后脱位或再手术,而非rTHA组有4例脱位(5%)和6例再手术(8%)(p分别为1.00和0.59)。结论:在本系列FNF全髋关节置换术中,与非全髋关节置换术相比,机器人辅助并没有明显延迟手术时间或增加手术时间。在平均3年的随访中,rTHA队列中无术后脱位或再手术。
{"title":"Low rates of dislocation and reoperation following robotic-assisted total hip arthroplasty for femoral neck fracture.","authors":"Jeffrey A O'Donnell, Daniel B Buchalter, Tracy M Borsinger, Sonia K Chandi, Colin C Neitzke, Geoffrey H Westrich, Elizabeth B Gausden","doi":"10.1177/11207000241312385","DOIUrl":"10.1177/11207000241312385","url":null,"abstract":"<p><strong>Introduction: </strong>Total hip arthroplasty (THA) is widely used for active, elderly patients with femoral neck fractures (FNF). Compared to THA for osteoarthritis, THA for FNF is associated with a higher incidence of dislocation and reoperation. Robotic assistance may improve component positioning and leg-length restoration in THA, but its use in FNF has not been described. The objective of this study was to assess the feasibility and perioperative outcomes of robotic-assisted THA (rTHA) for FNF.</p><p><strong>Methods: </strong>A retrospective review identified 93 patients undergoing 94 THAs for FNF from 2016 to 2023. 18 patients treated with MAKOplasty rTHA were compared to 76 non-rTHA. There were 69 (73%) women, the mean age was 71 years, and the mean follow-up was 3 years.</p><p><strong>Results: </strong>There was no significant difference in operative time between rTHA and non-rTHA cohorts (100 vs. 108 minutes, <i>p</i> = 0.19), and sub-analysis of acute FNFs (< 6 weeks), showed no difference in the meantime from presentation to surgery (18 vs. 25 hours, <i>p</i> = 0.24). There was no significant difference in mean leg-length discrepancy (LLD) (<i>p</i> = 0.19), number of outliers for acetabular anteversion (<i>p</i> = 0.80), or inclination (<i>p</i> = 0.55). There were no postoperative dislocations or reoperations in the rTHA cohort, compared to 4 dislocations (5%) and 6 reoperations (8%) in the non-rTHA cohort (<i>p</i> = 1.00 and 0.59, respectively).</p><p><strong>Conclusions: </strong>In this series of THA for FNF, robotic assistance did not significantly delay the time to surgery or increase the operative time compared to non-rTHA. At a mean follow-up of 3 years, there were no postoperative dislocations or reoperations in the rTHA cohort.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"402-409"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-05-19DOI: 10.1177/11207000251339063
Alistair I W Mayne, Awf Al-Shahwani, Lucie Gosling, Peter Wall, Angelos Politis, Callum McBryde
Background: Iliopsoas impingement after total hip replacement is an uncommon, but well recognised cause of residual groin pain. The primary aim of this study was to review patient outcomes following arthroscopic iliopsoas release. Secondary outcome was to determine the incidence of postoperative instability and review the literature on this complication.
Methods: A retrospective cohort study of all arthroscopic THR iliopsoas release procedures performed from 2012 until 2022 was undertaken. All patients had completed a minimum of 12 months of conservative treatment and had undergone a preoperative ultrasound-guided diagnostic steroid injection.Postoperatively, patients were classified into 3 categories at their 12-month clinical review: complete relief of symptoms; incomplete relief of symptoms but significant improvement; and no/minimal benefit. Any complications were documented and reviewed.
Results: 30 patients were included (31 hips); there were 14 males and 16 females. Mean age was 53.4 (range 34-77) years. 21 patients had a THR, 7 patients had a hip resurfacing, 1 patient had bilateral hip resurfacings and underwent bilateral release, and 1 patient had a revision THR. 2 patients were lost to follow-up, leaving 29 hips for inclusion in the study. Patients underwent arthroscopic release a median of 48 months following primary THR (range 12-180 months). At 12-month follow-up, 13 patients (44.8%) had complete relief of symptoms, 9 patients (31.0%) had incomplete relief of symptoms but significant improvement, and 7 patients (24.1) had no improvement.3 patients (10.3%) had frank anterior dislocation of their THR in the early postoperative period.
Conclusions: The majority of patients with persistent iliopsoas tendinitis following hip arthroplasty had significant improvement in symptoms with arthroscopic iliopsoas release. However, the series highlights the potential for postoperative instability and we would advise caution with regards to excessive capsular resection, as well as caution with postoperative physiotherapy in the immediate postoperative period.
{"title":"Arthroscopic iliopsoas release following hip arthroplasty surgery: a successful procedure but beware of instability!","authors":"Alistair I W Mayne, Awf Al-Shahwani, Lucie Gosling, Peter Wall, Angelos Politis, Callum McBryde","doi":"10.1177/11207000251339063","DOIUrl":"10.1177/11207000251339063","url":null,"abstract":"<p><strong>Background: </strong>Iliopsoas impingement after total hip replacement is an uncommon, but well recognised cause of residual groin pain. The primary aim of this study was to review patient outcomes following arthroscopic iliopsoas release. Secondary outcome was to determine the incidence of postoperative instability and review the literature on this complication.</p><p><strong>Methods: </strong>A retrospective cohort study of all arthroscopic THR iliopsoas release procedures performed from 2012 until 2022 was undertaken. All patients had completed a minimum of 12 months of conservative treatment and had undergone a preoperative ultrasound-guided diagnostic steroid injection.Postoperatively, patients were classified into 3 categories at their 12-month clinical review: complete relief of symptoms; incomplete relief of symptoms but significant improvement; and no/minimal benefit. Any complications were documented and reviewed.</p><p><strong>Results: </strong>30 patients were included (31 hips); there were 14 males and 16 females. Mean age was 53.4 (range 34-77) years. 21 patients had a THR, 7 patients had a hip resurfacing, 1 patient had bilateral hip resurfacings and underwent bilateral release, and 1 patient had a revision THR. 2 patients were lost to follow-up, leaving 29 hips for inclusion in the study. Patients underwent arthroscopic release a median of 48 months following primary THR (range 12-180 months). At 12-month follow-up, 13 patients (44.8%) had complete relief of symptoms, 9 patients (31.0%) had incomplete relief of symptoms but significant improvement, and 7 patients (24.1) had no improvement.3 patients (10.3%) had frank anterior dislocation of their THR in the early postoperative period.</p><p><strong>Conclusions: </strong>The majority of patients with persistent iliopsoas tendinitis following hip arthroplasty had significant improvement in symptoms with arthroscopic iliopsoas release. However, the series highlights the potential for postoperative instability and we would advise caution with regards to excessive capsular resection, as well as caution with postoperative physiotherapy in the immediate postoperative period.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"370-376"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}