Obesity contributes to the development of severe concomitant diseases and substantially degrades the quality of life. This pathological condition is caused by multiple risk factors including hazardous workplace exposures and genetic predisposition. The ApoE gene participates in regulation of lipid metabolism. Its most significant polymorphisms are rs429358 and rs7412 with the resulting е2, е3 and е4 alleles. This study did not consider effects of electromagnetic fields generated by office electrical equipment or the lifestyle of the subjects. The sample included people with a large age difference due to the rarity of the apolipoprotein е2 and е4 alleles. The sample was not standardized by age and years of work experience. The aim of this study was to investigate associations between the ApoE gene polymorphisms and body mass index in workers employed at a metallurgic plant. We examined 328 male office workers and workers of a converter workshop. The body mass index (BMI) was calculated based on the results of instrumental measurements of weight and height using the conventional formula. DNA was isolated from peripheral blood using the LumiPure DNA gel extraction kit, and polymorphisms were determined using amplification by Calero et al with modifications and horizontal agarose gel electrophoresis. The data were analyzed using the Kruskal – Wallis test. Statistically significant differences were established in the blue-collar workers. The highest mean BMI value was established in the e2 allele carriers. We found that people with the e2 allele in their genotype were more prone to obesity. We also assume a potential association between the unsafe work environment and a more pronounced manifestation of the phenotype. These findings can be used for identifying individuals at risk and taking timely preventive measures.
{"title":"Polymorphism of the ApoE gene as a risk factor of obesity in workers exposed to occupational hazards at ferrous metallurgy enterprises","authors":"D.D. Polyanina, I.А. Bereza, А.М. Amromina, D.R. Shaikhova, S.G. Astakhova, М.P. Sutunkova, V.B. Gurvich","doi":"10.21668/health.risk/2023.2.15.eng","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.15.eng","url":null,"abstract":"Obesity contributes to the development of severe concomitant diseases and substantially degrades the quality of life. This pathological condition is caused by multiple risk factors including hazardous workplace exposures and genetic predisposition. The ApoE gene participates in regulation of lipid metabolism. Its most significant polymorphisms are rs429358 and rs7412 with the resulting е2, е3 and е4 alleles. This study did not consider effects of electromagnetic fields generated by office electrical equipment or the lifestyle of the subjects. The sample included people with a large age difference due to the rarity of the apolipoprotein е2 and е4 alleles. The sample was not standardized by age and years of work experience. The aim of this study was to investigate associations between the ApoE gene polymorphisms and body mass index in workers employed at a metallurgic plant. We examined 328 male office workers and workers of a converter workshop. The body mass index (BMI) was calculated based on the results of instrumental measurements of weight and height using the conventional formula. DNA was isolated from peripheral blood using the LumiPure DNA gel extraction kit, and polymorphisms were determined using amplification by Calero et al with modifications and horizontal agarose gel electrophoresis. The data were analyzed using the Kruskal – Wallis test. Statistically significant differences were established in the blue-collar workers. The highest mean BMI value was established in the e2 allele carriers. We found that people with the e2 allele in their genotype were more prone to obesity. We also assume a potential association between the unsafe work environment and a more pronounced manifestation of the phenotype. These findings can be used for identifying individuals at risk and taking timely preventive measures.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.03
I. Bogdan, M.D. Gornostalev, V. Kuzmenkov, T. A. Potyaeva, D. Chistyakova
In recent years, Russia has seen a considerable decrease in the number of consumers of alcoholic beverages. However, mortality from alcohol-related causes is still quite high. In the context of the Concept for lowering alcohol use in the Russian Federation up to 2030, it is promising to assess the risks of alcohol involvement of Muscovites as residents of a certain metropolitan region. The purpose of the study is to identify the characteristics of alcohol intake by Moscow residents, including factors and risk groups. An empirical sociological survey (CATI, randomized sample, N = 1002) was conducted in October 2022 among adult residents of Moscow. The study has showed that 78 % of Muscovites have consumed alcohol over the past year; the rate of heavy drinking is 14 % among male drinkers and 7 % among female drinkers, which is consistent with data from previous studies conducted on a nationwide sample. Also, 16 % of Muscovites note that they have consumed homemade alcohol over the past month, which means that they represent a potential risk group for poisoning. The study identified the structure of alcohol consumption, which served as the foundation for consumer classification: “bar type” (24 %), “homemade alcohol of various strengths” (21 %), “strong alcohol and homemade wine” (20 %), “wine” (18 %), "only vodka" (17 %). Alcohol abuse is uncommon among young individuals. Involvement in drinking alcohol is frequently influenced by relatives (including parents), colleagues and friends, highlighting the need to address alcoholism's social components. Respondents evaluate the current anti-alcohol measures in Moscow rather positively.
{"title":"Alcohol consumption in a Russian metropolis: factors and risk groups","authors":"I. Bogdan, M.D. Gornostalev, V. Kuzmenkov, T. A. Potyaeva, D. Chistyakova","doi":"10.21668/health.risk/2023.2.03","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.03","url":null,"abstract":"In recent years, Russia has seen a considerable decrease in the number of consumers of alcoholic beverages. However, mortality from alcohol-related causes is still quite high. In the context of the Concept for lowering alcohol use in the Russian Federation up to 2030, it is promising to assess the risks of alcohol involvement of Muscovites as residents of a certain metropolitan region. The purpose of the study is to identify the characteristics of alcohol intake by Moscow residents, including factors and risk groups. An empirical sociological survey (CATI, randomized sample, N = 1002) was conducted in October 2022 among adult residents of Moscow. The study has showed that 78 % of Muscovites have consumed alcohol over the past year; the rate of heavy drinking is 14 % among male drinkers and 7 % among female drinkers, which is consistent with data from previous studies conducted on a nationwide sample. Also, 16 % of Muscovites note that they have consumed homemade alcohol over the past month, which means that they represent a potential risk group for poisoning. The study identified the structure of alcohol consumption, which served as the foundation for consumer classification: “bar type” (24 %), “homemade alcohol of various strengths” (21 %), “strong alcohol and homemade wine” (20 %), “wine” (18 %), \"only vodka\" (17 %). Alcohol abuse is uncommon among young individuals. Involvement in drinking alcohol is frequently influenced by relatives (including parents), colleagues and friends, highlighting the need to address alcoholism's social components. Respondents evaluate the current anti-alcohol measures in Moscow rather positively.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41445829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.17
B. Revich
Green spaces (green infrastructure, green areas) are important components of urban environment. They are able to mitigate health outcomes of climatic risks, exposure to urbanization and adverse environmental factors. Bigger areas covered with plants should increase their accessibility for people living in cities. Analysis of the results reported in foreign studies that addressed influence of green spaces on public health proves that they promote physical activity by urban citizens, sports included, development of interpersonal communication and social interactions, improve mental health, and reduce prevalence of diabetes mellitus and other diseases. In some cases massive construction of residential housing and public buildings in Russian megacities and large cities led to reduction in green areas. The existing construction standards in Russia do not consider the recommendation of the WHO/Europe that requires accessibility of green spaces within a 15–20 minute walking distance and provision of 9 m2 of green spaces per person. Utility of green spaces for public health depends on evenness of their distribution. In case their distribution is mosaic, their benefits for public health and protection capacities are reduced. The present review shows the importance, needs and advantages of developing green infrastructure with continuous canopy that create potent green shading.
{"title":"The significance of green spaces for protecting health of urban population","authors":"B. Revich","doi":"10.21668/health.risk/2023.2.17","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.17","url":null,"abstract":"Green spaces (green infrastructure, green areas) are important components of urban environment. They are able to mitigate health outcomes of climatic risks, exposure to urbanization and adverse environmental factors. Bigger areas covered with plants should increase their accessibility for people living in cities. Analysis of the results reported in foreign studies that addressed influence of green spaces on public health proves that they promote physical activity by urban citizens, sports included, development of interpersonal communication and social interactions, improve mental health, and reduce prevalence of diabetes mellitus and other diseases. In some cases massive construction of residential housing and public buildings in Russian megacities and large cities led to reduction in green areas. The existing construction standards in Russia do not consider the recommendation of the WHO/Europe that requires accessibility of green spaces within a 15–20 minute walking distance and provision of 9 m2 of green spaces per person. Utility of green spaces for public health depends on evenness of their distribution. In case their distribution is mosaic, their benefits for public health and protection capacities are reduced. The present review shows the importance, needs and advantages of developing green infrastructure with continuous canopy that create potent green shading.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42198487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.17.eng
B.A. Revich
Green spaces (green infrastructure, green areas) are important components of urban environment. They are able to mitigate health outcomes of climatic risks, exposure to urbanization and adverse environmental factors. Bigger areas covered with plants should increase their accessibility for people living in cities. Analysis of the results reported in foreign studies that addressed influence of green spaces on public health proves that they promote physical activity by urban citizens, sports included, development of interpersonal communication and social interactions, improve mental health, and reduce prevalence of diabetes mellitus and other diseases. In some cases massive construction of residential housing and public buildings in Russian megacities and large cities led to reduction in green areas. The existing construction standards in Russia do not consider the recommendation of the WHO/Europe that requires accessibility of green spaces within a 15–20 minute walking distance and provision of 9 m2 of green spaces per person. Utility of green spaces for public health depends on evenness of their distribution. In case their distribution is mosaic, their benefits for public health and protection capacities are reduced. The present review shows the importance, needs and advantages of developing green infrastructure with continuous canopy that create potent green shading.
{"title":"The significance of green spaces for protecting health of urban population","authors":"B.A. Revich","doi":"10.21668/health.risk/2023.2.17.eng","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.17.eng","url":null,"abstract":"Green spaces (green infrastructure, green areas) are important components of urban environment. They are able to mitigate health outcomes of climatic risks, exposure to urbanization and adverse environmental factors. Bigger areas covered with plants should increase their accessibility for people living in cities. Analysis of the results reported in foreign studies that addressed influence of green spaces on public health proves that they promote physical activity by urban citizens, sports included, development of interpersonal communication and social interactions, improve mental health, and reduce prevalence of diabetes mellitus and other diseases. In some cases massive construction of residential housing and public buildings in Russian megacities and large cities led to reduction in green areas. The existing construction standards in Russia do not consider the recommendation of the WHO/Europe that requires accessibility of green spaces within a 15–20 minute walking distance and provision of 9 m2 of green spaces per person. Utility of green spaces for public health depends on evenness of their distribution. In case their distribution is mosaic, their benefits for public health and protection capacities are reduced. The present review shows the importance, needs and advantages of developing green infrastructure with continuous canopy that create potent green shading.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.16.eng
N. Zaitseva, О. Dolgikh, D. Dianova
Ambient air pollution with potentially allergenic technogenic haptens facilitates occurrence of atopic reactions and creates favorable conditions for future development of allergic pathologies in exposed population. The aim of this study was to estimate formation of an IgE-mediated and IgG-mediated specific immune response to low-molecular chemical compounds introduced into the body by inhalation (nickel and phenol used as examples). The test groups were made of children (n = 99) and adults (n = 57) who lived under exposure to airborne nickel and phenol in levels not exceeding maximum permissible ones (up to 0.7 MPL). The reference groups included children (n = 95) and adults (n = 53) who lived on a conventionally clean territory. In the test groups, average daily exposure doses of airborne nickel and phenol varied between 0.7•10-6 and 9.3•10-6 mg/(kg•day) for children and between 3.5•10-6 and 5.0•10-5 mg/(kg•day) for adults (the doses were created by emissions from a non-ferrous metallurgy plant); this was 1.5–3.0 times higher than the same indicators in the reference groups. Levels of IgG specific to nickel were more than two times higher in the exposed groups; the exposed children had elevated levels of IgG specific to phenol in their blood, practically three times higher than in the reference group (р < 0.05). By using logistic regression models, we established a significant probabilistic cause-effect relation between elevated nickel levels in children’s blood and elevated levels of IgE-specific to nickel (R2 = 0.87; F = 468.58; р < 0.05). The assessment of the odds ratio made it possible to verify the relationship between nickel levels in blood and the increase in the level of IgE specific to nickel in children (OR = 8.96; 95% CI = 2.00–40.15) and in adults from the test group (OR = 3.12; 95 % CI = 1.10–9.40). The study results indicate that exposure to low levels of airborne nickel and phenol induces hypersensitivity to technogenic haptens in the exposed children and adults. Its distinctive features are an IgE-mediated reaction to nickel and IgG-mediated reaction to phenol. Hyperproduction of immunoglobulin E specific to nickel as well as IgG-antibodies specific to phenol in the exposed children and adults reflects levels of exposure to airborne nickel and phenol and is a peculiarity of a hyperactive immune response developing in the analyzed children on the test territory.
{"title":"Exposure to airborne nickel and phenol and features of the immune response mediated by E and G immunoglobulins","authors":"N. Zaitseva, О. Dolgikh, D. Dianova","doi":"10.21668/health.risk/2023.2.16.eng","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.16.eng","url":null,"abstract":"Ambient air pollution with potentially allergenic technogenic haptens facilitates occurrence of atopic reactions and creates favorable conditions for future development of allergic pathologies in exposed population. The aim of this study was to estimate formation of an IgE-mediated and IgG-mediated specific immune response to low-molecular chemical compounds introduced into the body by inhalation (nickel and phenol used as examples). The test groups were made of children (n = 99) and adults (n = 57) who lived under exposure to airborne nickel and phenol in levels not exceeding maximum permissible ones (up to 0.7 MPL). The reference groups included children (n = 95) and adults (n = 53) who lived on a conventionally clean territory. In the test groups, average daily exposure doses of airborne nickel and phenol varied between 0.7•10-6 and 9.3•10-6 mg/(kg•day) for children and between 3.5•10-6 and 5.0•10-5 mg/(kg•day) for adults (the doses were created by emissions from a non-ferrous metallurgy plant); this was 1.5–3.0 times higher than the same indicators in the reference groups. Levels of IgG specific to nickel were more than two times higher in the exposed groups; the exposed children had elevated levels of IgG specific to phenol in their blood, practically three times higher than in the reference group (р < 0.05). By using logistic regression models, we established a significant probabilistic cause-effect relation between elevated nickel levels in children’s blood and elevated levels of IgE-specific to nickel (R2 = 0.87; F = 468.58; р < 0.05). The assessment of the odds ratio made it possible to verify the relationship between nickel levels in blood and the increase in the level of IgE specific to nickel in children (OR = 8.96; 95% CI = 2.00–40.15) and in adults from the test group (OR = 3.12; 95 % CI = 1.10–9.40). The study results indicate that exposure to low levels of airborne nickel and phenol induces hypersensitivity to technogenic haptens in the exposed children and adults. Its distinctive features are an IgE-mediated reaction to nickel and IgG-mediated reaction to phenol. Hyperproduction of immunoglobulin E specific to nickel as well as IgG-antibodies specific to phenol in the exposed children and adults reflects levels of exposure to airborne nickel and phenol and is a peculiarity of a hyperactive immune response developing in the analyzed children on the test territory.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42385089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.15
D.D. Polyanina, I.A. Bereza, А.М. Amromina, D. Shaikhova, S. G. Astakhova, М.P. Sutunkova, V. Gurvich
Obesity contributes to the development of severe concomitant diseases and substantially degrades the quality of life. This pathological condition is caused by multiple risk factors including hazardous workplace exposures and genetic predisposition. The ApoE gene participates in regulation of lipid metabolism. Its most significant polymorphisms are rs429358 and rs7412 with the resulting е2, е3 and е4 alleles. This study did not consider effects of electromagnetic fields generated by office electrical equipment or the lifestyle of the subjects. The sample included people with a large age difference due to the rarity of the apolipoprotein е2 and е4 alleles. The sample was not standardized by age and years of work experience. The aim of this study was to investigate associations between the ApoE gene polymorphisms and body mass index in workers employed at a metallurgic plant. We examined 328 male office workers and workers of a converter workshop. The body mass index (BMI) was calculated based on the results of instrumental measurements of weight and height using the conventional formula. DNA was isolated from peripheral blood using the LumiPure DNA gel extraction kit, and polymorphisms were determined using amplification by Calero et al with modifications and horizontal agarose gel electrophoresis. The data were analyzed using the Kruskal – Wallis test. Statistically significant differences were established in the blue-collar workers. The highest mean BMI value was established in the e2 allele carriers. We found that people with the e2 allele in their genotype were more prone to obesity. We also assume a potential association between the unsafe work environment and a more pronounced manifestation of the phenotype. These findings can be used for identifying individuals at risk and taking timely preventive measures.
{"title":"Polymorphism of the ApoE gene as a risk factor of obesity in workers exposed to occupational hazards at ferrous metallurgy enterprises","authors":"D.D. Polyanina, I.A. Bereza, А.М. Amromina, D. Shaikhova, S. G. Astakhova, М.P. Sutunkova, V. Gurvich","doi":"10.21668/health.risk/2023.2.15","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.15","url":null,"abstract":"Obesity contributes to the development of severe concomitant diseases and substantially degrades the quality of life. This pathological condition is caused by multiple risk factors including hazardous workplace exposures and genetic predisposition. The ApoE gene participates in regulation of lipid metabolism. Its most significant polymorphisms are rs429358 and rs7412 with the resulting е2, е3 and е4 alleles. This study did not consider effects of electromagnetic fields generated by office electrical equipment or the lifestyle of the subjects. The sample included people with a large age difference due to the rarity of the apolipoprotein е2 and е4 alleles. The sample was not standardized by age and years of work experience. The aim of this study was to investigate associations between the ApoE gene polymorphisms and body mass index in workers employed at a metallurgic plant. We examined 328 male office workers and workers of a converter workshop. The body mass index (BMI) was calculated based on the results of instrumental measurements of weight and height using the conventional formula. DNA was isolated from peripheral blood using the LumiPure DNA gel extraction kit, and polymorphisms were determined using amplification by Calero et al with modifications and horizontal agarose gel electrophoresis. The data were analyzed using the Kruskal – Wallis test. Statistically significant differences were established in the blue-collar workers. The highest mean BMI value was established in the e2 allele carriers. We found that people with the e2 allele in their genotype were more prone to obesity. We also assume a potential association between the unsafe work environment and a more pronounced manifestation of the phenotype. These findings can be used for identifying individuals at risk and taking timely preventive measures.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44121274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.04
N. Zaitseva, S. Kleyn, D. V. Goryaev, А.М. Andrishunas, S. Balashov, S. Zagorodnov
The whole complex of air protection activities has been planned in the RF with its aim to reduce levels of ambient air pollution. It is being implemented actively now and as a result the quality of the environment should improve for more than 7 million people. In this study, an algorithm has been suggested for assessing effectiveness of air protection activities. It includes six subsequent stages. The algorithm was tested at heat and power enterprises located in a region participating in the Clean Air Federal project. As a result, it was established that these enterprises were sources of potential public health risks; 70 % of them belonged to high risk categories. Until air protection activities are implemented, heat and power enterprises pollute ambient air in some areas in the city (up to 29.9 single maximum MPC; up to 6.9 average daily MPC; up to 19.0 average annual MPC), create unacceptable health risks (up to 25.8 HI for acute exposure, 22.7 HI for chronic exposure, CRT is up to 3.28∙10-4), and cause more than 87 thousand additional disease cases. Implementation of air protection activities at heat and power enterprises will reduce local levels of ambient air pollution but we still expect hygienic standards to be violated for 10 chemicals up to 3–22 MPC and high health risks are likely to persist (up to 6.5–25.5 HI for acute exposure, 11.9–22.4 HI for chronic exposure, CRT will be up to 3.28∙10-4). Effectiveness of the air protection activities planned at heat and power enterprises corresponds to the target levels of the gross pollutant emissions (reduction by 20.56 % by 2024) set within the Clean Air Federal project but it is estimated as ‘unacceptable’ as per the health harm indicator, which is additional disease cases associated with activities of these enterprises (< 20 %). It is necessary to implement additional air protection activities with respect to 12 pollutants (nitrogen dioxide, particulate matter, carbon (soot), carbon oxide, sulfur dioxide, dihydrosulfide, inorganic dust containing silicon dioxide in %: 70–20, dimethyl benzene, ethyl benzene, benzene, formaldehyde, and kerosene); to use the best available technologies with respect to the most hazardous chemicals; to monitor public health in areas with elevated health risks; to implement complex medical and preventive activities.
{"title":"Effectiveness of complex plans for air protection activities at heat and power enterprises as per risk mitigation and health harm indicators","authors":"N. Zaitseva, S. Kleyn, D. V. Goryaev, А.М. Andrishunas, S. Balashov, S. Zagorodnov","doi":"10.21668/health.risk/2023.2.04","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.04","url":null,"abstract":"The whole complex of air protection activities has been planned in the RF with its aim to reduce levels of ambient air pollution. It is being implemented actively now and as a result the quality of the environment should improve for more than 7 million people. In this study, an algorithm has been suggested for assessing effectiveness of air protection activities. It includes six subsequent stages. The algorithm was tested at heat and power enterprises located in a region participating in the Clean Air Federal project. As a result, it was established that these enterprises were sources of potential public health risks; 70 % of them belonged to high risk categories. Until air protection activities are implemented, heat and power enterprises pollute ambient air in some areas in the city (up to 29.9 single maximum MPC; up to 6.9 average daily MPC; up to 19.0 average annual MPC), create unacceptable health risks (up to 25.8 HI for acute exposure, 22.7 HI for chronic exposure, CRT is up to 3.28∙10-4), and cause more than 87 thousand additional disease cases. Implementation of air protection activities at heat and power enterprises will reduce local levels of ambient air pollution but we still expect hygienic standards to be violated for 10 chemicals up to 3–22 MPC and high health risks are likely to persist (up to 6.5–25.5 HI for acute exposure, 11.9–22.4 HI for chronic exposure, CRT will be up to 3.28∙10-4). Effectiveness of the air protection activities planned at heat and power enterprises corresponds to the target levels of the gross pollutant emissions (reduction by 20.56 % by 2024) set within the Clean Air Federal project but it is estimated as ‘unacceptable’ as per the health harm indicator, which is additional disease cases associated with activities of these enterprises (< 20 %). It is necessary to implement additional air protection activities with respect to 12 pollutants (nitrogen dioxide, particulate matter, carbon (soot), carbon oxide, sulfur dioxide, dihydrosulfide, inorganic dust containing silicon dioxide in %: 70–20, dimethyl benzene, ethyl benzene, benzene, formaldehyde, and kerosene); to use the best available technologies with respect to the most hazardous chemicals; to monitor public health in areas with elevated health risks; to implement complex medical and preventive activities.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42001353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.09.eng
E. Valeeva, R. Galimova, A. Distanova, I.F. Suleymanova, D. M. Galiullina, N. Boyarinova, L. Salavatova, S.M. Isaeva
This study has shown that working conditions of basic occupational groups in the automotive industry involve combined exposure to several harmful occupational factors. Major harmful occupational factors include intense noise, vibration, work hardness and chemical levels; their intensity varies between permissible levels (the hazard category is 2.0) and harmful ones (the hazard category 3.1–3.2, harmful working conditions with hazard levels 1 or 2). This may induce occurrence or exacerbation of basic non-communicable diseases such as diseases of the circulatory system (CSDs), occupational and work-related diseases. CSDs were diagnosed in 37.7 % of workers employed at automotive productions. The most frequent diseases include hypertension (EH) that accounted for 28.2 %; cerebrovascular diseases (CVDs), 6.5 %; ischemic heart disease (IHD), 3.6 %. CSDs developed at an early age in workers exposed to harmful occupational factors belonging to the hazard category 3.1–3.2; these diseases became more frequent as work records got longer, and were more frequently exacerbated with acute cardiovascular conditions. We assessed the total cardiovascular risk using the SCORE scale and established that shares of people with high and very high cardiovascular risks were higher among painters, laboratory assistants responsible for chemical analysis, and repairmen. The attributive risk of new cardiovascular diseases ranged between 9.6 (turners) and 42.6 (repairmen) cases. The highest occupational CSDs causation was identified for repairmen and mechanics at mechanical assembly production; average causation was established for stampers, painters, laboratory assistants dealing with chemical analysis, crane operators, and turners.
{"title":"Work environment of the automotive industry as a risk factor of diseases of the circulatory system among workers","authors":"E. Valeeva, R. Galimova, A. Distanova, I.F. Suleymanova, D. M. Galiullina, N. Boyarinova, L. Salavatova, S.M. Isaeva","doi":"10.21668/health.risk/2023.2.09.eng","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.09.eng","url":null,"abstract":"This study has shown that working conditions of basic occupational groups in the automotive industry involve combined exposure to several harmful occupational factors. Major harmful occupational factors include intense noise, vibration, work hardness and chemical levels; their intensity varies between permissible levels (the hazard category is 2.0) and harmful ones (the hazard category 3.1–3.2, harmful working conditions with hazard levels 1 or 2). This may induce occurrence or exacerbation of basic non-communicable diseases such as diseases of the circulatory system (CSDs), occupational and work-related diseases. CSDs were diagnosed in 37.7 % of workers employed at automotive productions. The most frequent diseases include hypertension (EH) that accounted for 28.2 %; cerebrovascular diseases (CVDs), 6.5 %; ischemic heart disease (IHD), 3.6 %. CSDs developed at an early age in workers exposed to harmful occupational factors belonging to the hazard category 3.1–3.2; these diseases became more frequent as work records got longer, and were more frequently exacerbated with acute cardiovascular conditions. We assessed the total cardiovascular risk using the SCORE scale and established that shares of people with high and very high cardiovascular risks were higher among painters, laboratory assistants responsible for chemical analysis, and repairmen. The attributive risk of new cardiovascular diseases ranged between 9.6 (turners) and 42.6 (repairmen) cases. The highest occupational CSDs causation was identified for repairmen and mechanics at mechanical assembly production; average causation was established for stampers, painters, laboratory assistants dealing with chemical analysis, crane operators, and turners.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46267619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.02.eng
N.A. Lebedeva-Nesevria, S.S. Gordeeva
In this study, we have estimated alcohol consumption and alcohol-associated incidence in the RF regions in the ‘before crisis’ (2017–2019) and ‘crisis’ (2020–2022) periods. We identified types of the RF regions using hierarchical cluster analysis (Ward’s method) and relying on indirect indicators of alcohol consumption. As a result, we established considerable differences between the macro-regions (the Federal Districts) and RF regions as per alcohol consumption and severity of its outcomes. Poles in this differentiation are represented by ‘favorable’ regions in the Southern Russia where alcohol sales, alcohol-associated crime and incidence are low and ‘unfavorable’ regions located in the Far East and southern Siberia where alcohol-associated crime and incidence are high. We have shown in this study that retail alcohol sales cannot be considered a sufficient indicator to describe alcohol use in a given region. Thus, considerable volumes of alcohol sales involve severe socially significant outcomes in some regions (for example, the Khabarovsk region and Primorye) whereas such outcomes do not occur in other regions with similarly high alcohol sales (Moscow, Saint Petersburg, the Moscow region and the Leningrad region). The level of socioeconomic welfare on a given territory is confirmed as a significant determinant of alcohol consumption. We have also analyzed a correlation between economic vulnerability of RF regions during the ‘pandemic’ and ‘sanction’ crises and levels of alcohol consumption. The analysis revealed that large industrial regions, though expected to be vulnerable, turned out to be quite stable (it is probable due to delayed macroeconomic effects). We have not been able to identify any resources of improving a tense situation with alcohol consumption in economically unfavorable but less vulnerable subsidized agricultural regions. In general, the crisis period of 2020–2022 can be considered a source of additional health risks for the population in the RF regions where the situation with alcohol consumption was rather unfavorable in the ‘before crisis’ period.
{"title":"Alcohol consumption as health risk factor for the population in the RF regions in the ‘before crisis’ and ‘after crisis’ periods (2017–2022)","authors":"N.A. Lebedeva-Nesevria, S.S. Gordeeva","doi":"10.21668/health.risk/2023.2.02.eng","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.02.eng","url":null,"abstract":"In this study, we have estimated alcohol consumption and alcohol-associated incidence in the RF regions in the ‘before crisis’ (2017–2019) and ‘crisis’ (2020–2022) periods. We identified types of the RF regions using hierarchical cluster analysis (Ward’s method) and relying on indirect indicators of alcohol consumption. As a result, we established considerable differences between the macro-regions (the Federal Districts) and RF regions as per alcohol consumption and severity of its outcomes. Poles in this differentiation are represented by ‘favorable’ regions in the Southern Russia where alcohol sales, alcohol-associated crime and incidence are low and ‘unfavorable’ regions located in the Far East and southern Siberia where alcohol-associated crime and incidence are high. We have shown in this study that retail alcohol sales cannot be considered a sufficient indicator to describe alcohol use in a given region. Thus, considerable volumes of alcohol sales involve severe socially significant outcomes in some regions (for example, the Khabarovsk region and Primorye) whereas such outcomes do not occur in other regions with similarly high alcohol sales (Moscow, Saint Petersburg, the Moscow region and the Leningrad region). The level of socioeconomic welfare on a given territory is confirmed as a significant determinant of alcohol consumption. We have also analyzed a correlation between economic vulnerability of RF regions during the ‘pandemic’ and ‘sanction’ crises and levels of alcohol consumption. The analysis revealed that large industrial regions, though expected to be vulnerable, turned out to be quite stable (it is probable due to delayed macroeconomic effects). We have not been able to identify any resources of improving a tense situation with alcohol consumption in economically unfavorable but less vulnerable subsidized agricultural regions. In general, the crisis period of 2020–2022 can be considered a source of additional health risks for the population in the RF regions where the situation with alcohol consumption was rather unfavorable in the ‘before crisis’ period.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136281006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-01DOI: 10.21668/health.risk/2023.2.12
N. Vorobyeva, A. Vorobyeva, A. S. Vorontsova
COVID-19 poses a significant hazard as regards decompensation of underlying chronic diseases, specific damage to the cardiovascular system, and a high risk of negative health outcomes such as thrombotic events. The coronavirus infection pathogenesis is rather complicated and has not been studied yet; this is largely due to peculiar features of the virus and the initial state of homeostasis in a patient. In this study, our aim was to analyze molecular-genetic markers of homeostasis in patients with the new coronavirus infection COVID-19 as a prognostic trigger of developing pro-thrombotic readiness. Hospitalized patients with COVID-19 were chosen as study objects. We performed molecular-genetic analysis of basic genes significant for homeostasis including several factors such as V (rs6025), II (rs1799963), I (rs1800790), VII (rs6046), XIII A1 (rs5985)), IGN A2 (rs1126643), IGN B3 (rs5918), and PAI-1 (rs1799889). The thrombinemia severity was identified by thrombin generation tests using the Ceveron®alpha automated coagulation analyzer with TGA-module. Allelic variants of PAI-1, prothrombin (FII), and fibrinogen (FI) determined high thrombinemia as per the thrombin kinetics test (endogenous thrombin potential (AUC), peak thrombin concentration (peak-thrombin), time necessary to reach thrombin peak (tPeak), levels of fibrinogen and D-dimer) in COVID-19 patients during the entire hospitalization. We established that elevated thrombin generation becoming apparent through elevated levels of endogenous thrombin potential (AUC) might be a prognostic indicator of the pro-thrombotic state in patients with genetic polymorphisms of PAI-I and fibrinogen. The study results indicate that pro-thrombotic readiness is determined genetically in case COVID-19 patients have allelic variants in PAI-I, prothrombin (factor II) and fibrinogen (factor I) genes.
{"title":"Predicting risks of prothrombotic readiness under COVID-19 using genetic testing","authors":"N. Vorobyeva, A. Vorobyeva, A. S. Vorontsova","doi":"10.21668/health.risk/2023.2.12","DOIUrl":"https://doi.org/10.21668/health.risk/2023.2.12","url":null,"abstract":"COVID-19 poses a significant hazard as regards decompensation of underlying chronic diseases, specific damage to the cardiovascular system, and a high risk of negative health outcomes such as thrombotic events. The coronavirus infection pathogenesis is rather complicated and has not been studied yet; this is largely due to peculiar features of the virus and the initial state of homeostasis in a patient. In this study, our aim was to analyze molecular-genetic markers of homeostasis in patients with the new coronavirus infection COVID-19 as a prognostic trigger of developing pro-thrombotic readiness. Hospitalized patients with COVID-19 were chosen as study objects. We performed molecular-genetic analysis of basic genes significant for homeostasis including several factors such as V (rs6025), II (rs1799963), I (rs1800790), VII (rs6046), XIII A1 (rs5985)), IGN A2 (rs1126643), IGN B3 (rs5918), and PAI-1 (rs1799889). The thrombinemia severity was identified by thrombin generation tests using the Ceveron®alpha automated coagulation analyzer with TGA-module. Allelic variants of PAI-1, prothrombin (FII), and fibrinogen (FI) determined high thrombinemia as per the thrombin kinetics test (endogenous thrombin potential (AUC), peak thrombin concentration (peak-thrombin), time necessary to reach thrombin peak (tPeak), levels of fibrinogen and D-dimer) in COVID-19 patients during the entire hospitalization. We established that elevated thrombin generation becoming apparent through elevated levels of endogenous thrombin potential (AUC) might be a prognostic indicator of the pro-thrombotic state in patients with genetic polymorphisms of PAI-I and fibrinogen. The study results indicate that pro-thrombotic readiness is determined genetically in case COVID-19 patients have allelic variants in PAI-I, prothrombin (factor II) and fibrinogen (factor I) genes.","PeriodicalId":12945,"journal":{"name":"Health Risk Analysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45758689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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