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Assessment of the content of heavy metals in the snow cover and hair in children 评估儿童雪被和头发中的重金属含量
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1266-1271
S. Shayakhmetov, A. Merinov, O. Zhurba, A. Alekseenko
Introduction. Environmental pollution leads to the need for regular monitoring and analysis of the content of toxic elements in the components of the environment and biosubstrates of the population to determine the degree of contamination of the territory, their accumulation in the body and assess the risk of health disorders. Materials and methods. Samples of snow cover were taken from eleven different sections of functional zones, and 52 hair samples were examined in two groups of children in different schools of the city. Determination of the content of water–soluble heavy metals and arsenic (HMAr) was carried out by atomic absorption method on the AAC-240 DUO “Agilent Technolgies” device. Results. In the snow cover of individual functional zones of Svirsk, a significant excess of Cu, Zn, Mn, Cd, Pb, and As content was found in comparison with background values in the range of 2–11 times. Indicator elements (Mn, Cr, Zn, Cd, As) reflecting the specifics of increased accumulation of HMAr in the hair of children in different areas of the city were identified. Strong correlations (r = 0.78–0.83) were established between the content of HMAr in the snow cover near schools and in the hair in the examined groups of children. Limitations. The assessment of content of HMs in the snow cover and in the hair in children population was evaluated without determining the accumulation of elements in the soil and migration to plant cultures. Conclusion. The revealed high levels of accumulation of HMAr in the snow cover and hair in children in Svirsk, due to the significant anthropogenic impact of emissions from industrial enterprises, motor vehicles, and residential households, indicate the tension of the environmental situation in the city and the need to implement a set of measures to improve it.
导言。环境污染导致需要定期监测和分析环境成分和人口生物基质中有毒元素的含量,以确定领土的污染程度、其在体内的积累情况以及评估健康疾病的风险。 材料和方法从功能区的 11 个不同地段采集了积雪样本,并对该市不同学校两组儿童的 52 份头发样本进行了检测。水溶性重金属和砷(HMAr)含量的测定是在 AAC-240 DUO "Agilent Technolgies "设备上通过原子吸收法进行的。 研究结果在斯维尔斯克个别功能区的积雪覆盖层中,发现铜、锌、锰、镉、铅和砷的含量与背景值相比明显超标,范围在 2-11 倍之间。确定了反映该市不同地区儿童头发中 HMAr 积累增加具体情况的指标元素(锰、铬、锌、镉、砷)。学校附近积雪中的 HMAr 含量与受检儿童群体头发中的 HMAr 含量之间存在很强的相关性(r = 0.78-0.83)。 局限性。在评估雪层和儿童毛发中的 HMs 含量时,没有确定元素在土壤中的积累和向植物培养物中的迁移。 结论由于工业企业、机动车辆和居民家庭排放的废气对人类产生了重大影响,斯维尔斯克市雪层和儿童头发中的 HMAr 积累水平较高,这表明该市的环境状况十分紧张,需要采取一系列措施加以改善。
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引用次数: 0
Influence of ergonomic parameters of schoolchildren’s workplaces on the functional state of the nervous system in adolescents 学生工作场所的人体工程学参数对青少年神经系统功能状态的影响
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1327-1333
A. V. Ablyaeva, Lilia M. Fatkhutdinova
Introduction. Modern learning environment is a source of potential risk for the development of neurological problems among schoolchildren. The aim of this study is to analyze the influence of ergonomic factors of workplaces on the functional state of the nervous system in older adolescents in the modern educational environment. Materials and methods. The ergonomic assessment of workplaces in the school at the individual workplace was given; the study of subjective complaints from the nervous system in adolescents and related factors during the questionnaire survey of schoolchildren and parents. Indicators of the functional state of the nervous system in adolescents were evaluated using the method of M.P. Moroz. Results. Headache complaints are highly prevalent among adolescents. In the course of the study, we found that staying in an irrational working posture increases the likelihood of headaches among adolescents. In addition, the irrationality of the working posture and the mismatch of the size of educational furniture with the anthropometric data of adolescents, statistically significantly affect the on the change in the indicators of the functional state of the nervous system in adolescents. Limitations. Limitations of the study include the fact that the study included groups of 15–16-year adolescents. The study is also limited by the fact that it was cross-sectional in nature. Studies investigating the influence of school ergonomic factors on the state of the nervous system of schoolchildren in dynamics may be promising. Conclusion. To prevent damage to the nervous system, it is important to observe ergonomic principles, teach adolescents to maintain a rational working posture in school.
引言现代学习环境是学龄儿童出现神经系统问题的潜在风险来源。 本研究旨在分析工作场所的人体工程学因素对现代教育环境中高年级青少年神经系统功能状态的影响。 材料和方法对学校各工作场所的人体工程学进行评估;在对学生和家长进行问卷调查时,研究青少年神经系统的主观不适及相关因素。采用 M.P. Moroz 的方法对青少年神经系统功能状态的指标进行了评估。 结果显示头痛主诉在青少年中非常普遍。在研究过程中,我们发现保持不合理的工作姿势会增加青少年头痛的可能性。此外,工作姿势的不合理和教育家具尺寸与青少年人体测量数据的不匹配,在统计学上对青少年神经系统功能状态指标的变化有显著影响。 局限性。该研究的局限性包括研究对象为 15-16 岁的青少年群体。研究还受到横断面性质的限制。对学校人体工程学因素对学龄儿童神经系统状态的动态影响进行调查研究可能会大有希望。 结论为防止神经系统受损,必须遵守人体工程学原则,教导青少年在学校保持合理的工作姿势。
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引用次数: 0
Methodology for assessing the probability of hearing loss caused by noise 评估噪音导致听力损失概率的方法
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1286-1291
E. A. Preobrazhenskaya, A. Sukhova, I. Yatsyna
Introduction. Predicting occupational hearing loss is a promising direction in the health protection of industrial workers. The purpose of the study is to develop and test a methodology for assessing the probability of hearing loss caused by noise, taking into account quantitative criteria for assessing the degree of hearing loss adopted in the Russian Federation. Materials and methods. The assessment of the probability of hearing loss caused by noise is carried out in accordance with GOST R ISO 1999–2017 and includes the determination of age, noise, and general hearing loss. To quantify the degree of hearing loss, a combination of audiometric frequencies of 500, 1000, 2000, 4000 Hz is used in accordance with the classification of the degree of hearing loss caused by noise. The probability of occupational hearing loss caused by noise (%) is determined by plotting the distribution of probabilistic hearing thresholds due to age and noise for the corresponding percentiles (10, 50, 90%). Results. The developed methodology complements and specifies the requirements of GOST R ISO 1999-2017 with respect to the combination of audiometric frequencies, according to which the probability of hearing loss caused by noise is assessed. The boundary thresholds of audibility, the excess of which indicates the presence of a certain degree of hearing loss. Based on the developed methodology, the probabilistic thresholds of audibility at noise exposure of 85, 90, 95, 100 dBA are calculated. The probability of occuptional hearing loss is determined depending on age, work experience, and noise exposure. Limitations. The limitations of the study are determined by the features of the model for assessing hearing loss due to noise exposure according to GOST ISO 1999–2017 and the criteria for assessing the degree of hearing loss in noise workers at audiometric frequencies of 500, 1000, 2000, 4000 Hz. Conclusion. The developed algorithm will make it possible to determine the probability of hearing loss caused by noise, predict the timing of the development of occupational hearing loss depending on the intensity and duration of noise exposure, the age of the employee, and develop risk-oriented preventive programs.
导言。预测职业性听力损失是保护产业工人健康的一个有前途的方向。 本研究的目的是根据俄罗斯联邦采用的听力损失程度量化评估标准,制定并测试评估噪声导致听力损失概率的方法。 材料和方法。噪声导致听力损失概率的评估按照 GOST R ISO 1999-2017 标准进行,包括年龄、噪声和一般听力损失的测定。为了量化听力损失程度,根据噪声导致听力损失程度的分类,使用了 500、1000、2000 和 4000 Hz 的测听频率组合。通过绘制相应百分位数(10%、50%、90%)的年龄和噪声导致的听阈概率分布图,确定噪声导致职业性听力损失的概率(%)。 结果。所开发的方法补充并明确了 GOST R ISO 1999-2017 中有关测听频率组合的要求,根据这些频率组合来评估噪声导致听力损失的概率。可听度的边界阈值,超过该阈值表明存在一定程度的听力损失。根据开发的方法,计算出噪音暴露在 85、90、95 和 100 dBA 时的可听度概率阈值。职业性听力损失的概率取决于年龄、工作经验和噪声暴露。 局限性。该研究的局限性取决于根据 GOST ISO 1999-2017 评估噪声暴露所致听力损失模型的特点,以及在听力测定频率为 500、1000、2000 和 4000 Hz 时评估噪声工人听力损失程度的标准。 结论通过所开发的算法,可以确定噪声导致听力损失的概率,根据噪声暴露的强度和持续时间、员工年龄预测职业性听力损失的发展时间,并制定以风险为导向的预防计划。
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引用次数: 0
Assessment of the annual trend of chemical aerogenic risk to health and mortality of the population at an industrial center 评估化学气体对工业中心居民健康和死亡率的年度影响趋势
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1375-1380
N. V. Efimova, Marina V. Kuzmina, Elena V. Bobkova
Introduction. Ambient air pollution determines high levels of risk to public health, causing excess mortality. The purpose of the study is to analyze the dependence of the seasonal dynamics of pollutants and mortality from major non-infectious diseases in the population of the industrial center of Eastern Siberia. Materials and methods. Air pollution in Bratsk was assessed based on data from monitoring systems for 2017–2022, taking into account one-time, average monthly and annual concentrations. Hazard indices and mortality rates (MR) from major causes were calculated. The annual trend in indicators are assessed using seasonality indices (SI). Results. Features of the seasonal dynamics of pollutants were revealed: maximum fluctuations in SI are characteristic of benzo(a)pyrene (22% in the warm season, 214% in the cold season), formaldehyde (219 and 65%, respectively). The SI for mortality had significant fluctuations throughout the year and varied across age groups and disease classes. Changes in seasonality have been noted during the COVID-19 pandemic. Average monthly MR in the older group is associated with concentrations of PM2.5, formaldehyde, NO2. Limitations of the study are related to the limited data on monitoring pollutants, inevitable errors in conditional division into seasons, and the impossibility of accurately determining the cause of death during a pandemic. Conclusion. The use of average monthly data on MR values and pollutant concentrations confirms the dependence of population mortality on air pollution when studying this phenomenon in medium-sized cities with high levels of hazard indices.
导言。环境空气污染会对公众健康造成严重危害,导致超额死亡率。 本研究旨在分析污染物的季节动态与东西伯利亚工业中心人口主要非传染性疾病死亡率的关系。 材料和方法根据监测系统提供的 2017-2022 年数据,对布拉茨克的空气污染情况进行了评估,考虑到了一次性、月均浓度和年均浓度。计算了主要原因造成的危害指数和死亡率(MR)。使用季节性指数 (SI) 评估指标的年度趋势。 结果。揭示了污染物的季节性动态特征:苯并(a)芘(暖季 22%,冷季 214%)和甲醛(分别为 219%和 65%)的季节性指数波动最大。死亡率的 SI 在全年都有显著波动,不同年龄组和不同疾病类别的 SI 也各不相同。在 COVID-19 大流行期间,已注意到季节性的变化。老年组的月平均 MR 与 PM2.5、甲醛、二氧化氮的浓度有关。 这项研究的局限性在于监测污染物的数据有限、按季节划分条件不可避免地存在误差以及无法准确确定大流行期间的死亡原因。 结论在研究危险指数较高的中等城市的空气污染现象时,使用 MR 值和污染物浓度的月平均数据证实了人口死亡率与空气污染的关系。
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引用次数: 0
The role of physical overstrain and hypodynamia in the development of the low back pain 过度劳累和低动力症在腰背痛发病中的作用
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1309-1314
V. A. Shirokov, N. Terekhov, A. V. Potaturko
Introduction. The pain in the lower back (BCC) has a wide distribution among the working people’s age and is a frequent cause of temporary disability. The identification of risk factors for the back pain is necessary to address expert issues and developing measures for prevention of incidence. Materials and methods. There were studied prevalence odds ratio (OR) for the development of the low back pain (LBP) in two thousand nine hundred fifteen working patients with different indicators of hardness of the labour process and levels of physical activity (PA). Results. According to the special assessment of the working conditions, the harmful (3rd) class of hardness of the labour process in comparison with the 1st and 2nd classes (optimal and permissible) increased the LBP prevalence from 31.6 to 37.1% with OR = 1.27 at 95% Ci (1.03–1.43), p <0.05. No reliable differences were obtained under comparing classes separately with the 1st class. According to the International questionnaire of physical activity, the LBP prevalence under an intensive PA is 29.3% with OR = 1.5 at 95% CI (1.6–2.11), at a low PA – 37.2% with OR = 2.15 at 95% Ci (1.07–4.3). The smallest LBP prevalence was revealed in a moderate PA mode throughout the day (21.6%). Limitations. The present study has a limitation associated with the inconsistency of cards for special assessment of working conditions and the International questionnaire cards. Conclusion. Data were obtained about the absence of reliable differences in the distribution and odds ratio for the development of LBP between workers by classes of hardness of the labour process. Workers with moderate and low PA have reliably low LBP prevalence.
简介下背部疼痛(BCC)在工作年龄段的人群中分布广泛,是导致暂时性残疾的常见原因。 要解决专家提出的问题并制定预防发病的措施,就必须确定腰痛的危险因素。 材料和方法。研究了 2 915 名劳动患者腰背痛(LBP)发病率的几率比(OR),这些患者的劳动强度和体力活动(PA)水平有不同的指标。 结果。根据对工作条件的特殊评估,与第一级和第二级(最佳和允许)相比,有害(第三级)的劳动过程硬度使腰背痛的发病率从 31.6% 上升到 37.1%,OR = 1.27,95% Ci (1.03-1.43),P <0.05。将各班级与第一班级分别进行比较,未发现可靠的差异。根据国际体力活动调查问卷,高强度体力活动的枸杞痛患病率为 29.3%,OR = 1.5,95% Ci (1.6-2.11);低强度体力活动的患病率为 37.2%,OR = 2.15,95% Ci (1.07-4.3)。全天中度活动量模式的枸杞痛发生率最小(21.6%)。 局限性。本研究的局限性在于工作条件特别评估卡与国际问卷卡不一致。 结论。本研究获得的数据表明,不同劳动强度的工人患腰椎间盘突出症的分布和几率没有可靠的差异。中度和低度劳动强度工人的枸杞多糖症发病率较低。
{"title":"The role of physical overstrain and hypodynamia in the development of the low back pain","authors":"V. A. Shirokov, N. Terekhov, A. V. Potaturko","doi":"10.47470/0016-9900-2023-102-12-1309-1314","DOIUrl":"https://doi.org/10.47470/0016-9900-2023-102-12-1309-1314","url":null,"abstract":"Introduction. The pain in the lower back (BCC) has a wide distribution among the working people’s age and is a frequent cause of temporary disability. The identification of risk factors for the back pain is necessary to address expert issues and developing measures for prevention of incidence. Materials and methods. There were studied prevalence odds ratio (OR) for the development of the low back pain (LBP) in two thousand nine hundred fifteen working patients with different indicators of hardness of the labour process and levels of physical activity (PA). Results. According to the special assessment of the working conditions, the harmful (3rd) class of hardness of the labour process in comparison with the 1st and 2nd classes (optimal and permissible) increased the LBP prevalence from 31.6 to 37.1% with OR = 1.27 at 95% Ci (1.03–1.43), p <0.05. No reliable differences were obtained under comparing classes separately with the 1st class. According to the International questionnaire of physical activity, the LBP prevalence under an intensive PA is 29.3% with OR = 1.5 at 95% CI (1.6–2.11), at a low PA – 37.2% with OR = 2.15 at 95% Ci (1.07–4.3). The smallest LBP prevalence was revealed in a moderate PA mode throughout the day (21.6%). Limitations. The present study has a limitation associated with the inconsistency of cards for special assessment of working conditions and the International questionnaire cards. Conclusion. Data were obtained about the absence of reliable differences in the distribution and odds ratio for the development of LBP between workers by classes of hardness of the labour process. Workers with moderate and low PA have reliably low LBP prevalence.","PeriodicalId":13009,"journal":{"name":"Hygiene and sanitation","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative determination of polycyclic aromatic hydrocarbons in the blood by high-performance liquid chromatography with fluorimetric detection for the tasks of socio-hygienic monitoring 利用高效液相色谱法和荧光检测法定量测定血液中的多环芳烃,以完成社会卫生监测任务
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1381-1388
Nina V. Zaytseva, T. Nurislamova, T. D. Karnazhitskaya, Mariya O. Starchikova
Introduction. The polycyclic aromatic hydrocarbons (PAH) refer to the group of priority environmental pollutants that enter the human body by inhalation, orally, through the skin, causing a long-term impact on metabolic processes, chronic and oncological diseases. To assess the impact of polycyclic aromatic hydrocarbons on the health of the population, it is actual to evaluate their content in human biological media. The purpose of the study is to develop and apply a methodology for determining the polycyclic aromatic hydrocarbons (naphthalene, 2-methylnaphthalene, anthracene, the 9-methylanthracene, pyrene and benz (a) pyrene) in the blood by a method of highly efficient liquid chromatography with fluoremetric detection (HPLC-FDD) for social and hygienic monitoring problems. Materials and methods. The object of research was biological media (blood samples). Studies on the development of the technique were carried out on the Shimadzu liquid chromatograph with a fluoremetric detector RF-20A. The approximation of the technique was carried out within the framework of deeper studies of children health in residents in territories with various exposure levels. Results. The conditions for sample production and parameters of the chromatographic analysis of blood PAH by the HPLC / FDD method were established. The degree of extraction of PAH from the blood by the method of liquid extraction was 77-100%. The analysis of blood PAH showed average group concentrations to be reliably higher (p <0.05) in the biological media in children living in the zone of influence of emissions of industrial enterprises. Priority compounds detected in the blood of the students are pyrene, naphthalene, 2-methylnaphthalene, Limitations are due to the period of selection of biological media of the different age groups in the territories of the Russian Federation with various levels of exposure. The expansion of the list of the populations can become a direction of further research on assessing the impact of polycyclic aromatic hydrocarbons on human health. Conclusion. The developed methodology can be used in hygienic studies for assessing the risk of conditions of exposure to polycyclic aromatic hydrocarbons for health of residents in the territories with different anthropogenic loads.
导言。多环芳烃(PAH)是指通过吸入、口服或皮肤进入人体,对新陈代谢过程、慢性疾病和肿瘤疾病造成长期影响的一类重点环境污染物。为了评估多环芳烃对人体健康的影响,必须对其在人体生物介质中的含量进行评估。 本研究的目的是开发和应用一种方法,通过高效液相色谱-荧光检测法(HPLC-FDD)测定血液中的多环芳烃(萘、2-甲基萘、蒽、9-甲基蒽、芘和苯(a)芘),以解决社会和卫生监测问题。 材料和方法。研究对象是生物介质(血液样本)。在配有荧光检测器 RF-20A 的岛津液相色谱仪上对该技术的开发进行了研究。在对不同暴露水平地区居民的儿童健康状况进行深入研究的框架内,对该技术进行了近似分析。 研究结果通过 HPLC / FDD 方法确定了血液多环芳烃的样品生产条件和色谱分析参数。采用液体萃取法对血液中多环芳烃的提取率为 77%-100%。对血液中多环芳烃的分析表明,生活在工业企业排放物影响区内的儿童,其生物介质中多环芳烃的平均组浓度明显较高(p <0.05)。在学生血液中检测到的主要化合物是芘、萘、2-甲基萘。扩大人群清单可以成为评估多环芳烃对人体健康影响的进一步研究方向。 结论所开发的方法可用于卫生学研究,以评估接触多环芳烃的条件对不同人为负荷地区居民健康的风险。
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引用次数: 0
Socio-economic damage caused by nutritionally-dependent diseases of the population 营养依赖性疾病对人口造成的社会经济损害
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1354-1360
O.G. Bogdanova
Introduction. In recent decades, the prevalence of nutritionally-dependent diseases has acquired the effect of globalization, which in general causes an increase in deaths from chronic non-communicable diseases and the emergence of socio-economic damage. The aim of the study is to assess the socio-economic damage caused by non-communicable nutritionally-dependent diseases among the population of the Republic of Buryatia. Materials and methods. The mortality rates of the population of the Republic of Buryatia due to non-communicable nutritionally-dependent diseases over 2011–2020 have been studied. Based on the principle of potential demography, social and economic damage due to premature mortality from these causes is calculated. Results. It was shown that share of the mortality from alimentary-dependent pathology in the Republic of Buryatia accounted for20.80% (20.54; 21.05) of all the mortality of the able-bodied population. Social losses annually averaged 52586.80 (50314.48; 54859.12) of non-lived person-years to the end of working age. Associated probable economic losses in the aggregate for the specified period from 33779.65 to 56299.42 million rubles. Conclusion. The analysis carried out in this work showed not only the significance of demographic losses from non-communicable nutritionally-dependent diseases, but also the significance of socio-economic damage. Together, this serves as objective evidence of the justified need for financial obligations to protect and promote the health of the population of the Republic of Buryatia to reduce the prevalence of risk factors through the prism of increasing awareness of a healthy lifestyle, including the principles of optimal nutrition. Limitations. The results of this study are due only to direct socio-economic losses, excluding indirect losses, which requires further research.
导言。近几十年来,营养依赖性疾病的流行受到了全球化的影响,总体而言,全球化导致慢性非传染性疾病死亡人数增加,社会经济损失也随之出现。 本研究旨在评估非传染性营养依赖性疾病在布里亚特共和国人口中造成的社会经济损失。 材料和方法研究了 2011-2020 年布里亚特共和国居民因非传染性营养依赖性疾病导致的死亡率。根据潜在人口学原理,计算了因这些原因导致的过早死亡造成的社会和经济损失。 结果显示结果表明,布里亚特共和国因膳食依赖性疾病导致的死亡率占所有健全人口死亡率的 20.80%(20.54; 21.05)。每年的社会损失平均为 52586.80 (50314.48; 54859.12)个工作年龄末期的无寿命人年。在规定期限内,相关的可能经济损失总额为 3.377965 亿卢布至 5.629942 亿卢布。 结论这项工作所做的分析不仅显示了非传染性营养依赖性疾病造成的人口损失的重要性,还显示了社会经济损失的重要性。这些都客观地证明,有必要通过提高对健康生活方式(包括最佳营养原则)的认识,承担起保护和促进布里亚特共和国居民健康的财政义务,以减少危险因素的流行。 局限性。本研究的结果只涉及直接的社会经济损失,不包括间接损失,这需要进一步研究。
{"title":"Socio-economic damage caused by nutritionally-dependent diseases of the population","authors":"O.G. Bogdanova","doi":"10.47470/0016-9900-2023-102-12-1354-1360","DOIUrl":"https://doi.org/10.47470/0016-9900-2023-102-12-1354-1360","url":null,"abstract":"Introduction. In recent decades, the prevalence of nutritionally-dependent diseases has acquired the effect of globalization, which in general causes an increase in deaths from chronic non-communicable diseases and the emergence of socio-economic damage. The aim of the study is to assess the socio-economic damage caused by non-communicable nutritionally-dependent diseases among the population of the Republic of Buryatia. Materials and methods. The mortality rates of the population of the Republic of Buryatia due to non-communicable nutritionally-dependent diseases over 2011–2020 have been studied. Based on the principle of potential demography, social and economic damage due to premature mortality from these causes is calculated. Results. It was shown that share of the mortality from alimentary-dependent pathology in the Republic of Buryatia accounted for20.80% (20.54; 21.05) of all the mortality of the able-bodied population. Social losses annually averaged 52586.80 (50314.48; 54859.12) of non-lived person-years to the end of working age. Associated probable economic losses in the aggregate for the specified period from 33779.65 to 56299.42 million rubles. Conclusion. The analysis carried out in this work showed not only the significance of demographic losses from non-communicable nutritionally-dependent diseases, but also the significance of socio-economic damage. Together, this serves as objective evidence of the justified need for financial obligations to protect and promote the health of the population of the Republic of Buryatia to reduce the prevalence of risk factors through the prism of increasing awareness of a healthy lifestyle, including the principles of optimal nutrition. Limitations. The results of this study are due only to direct socio-economic losses, excluding indirect losses, which requires further research.","PeriodicalId":13009,"journal":{"name":"Hygiene and sanitation","volume":"42 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional disorders of the peripheral nervous system in metallurgical workers 冶金工人周围神经系统的功能紊乱
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1292-1296
E. Bakhtereva, E.L. Leiderman, T.A. Riabkova
Introduction. Early detection of functional changes in the nervous system makes it possible to clarify the etiopathogenetic effect of a whole set of adverse industrial factors, form a group at risk of occupational diseases, and develop preventive programs for given the main structural targets. The purpose of the study was to identify characteristics of functional disorders of the peripheral nervous systems in metallurgists exposed to occupational hazards. Materials and methods. We examined two cohorts of workers: a control cohort of forty men unexposed to occupational risk factors and a case cohort of 60 male employees of a metallurgical plant situated in the Sverdlovsk Region. The cohorts were matched by age (mean: 38.8±7.6 years) and work experience (5.1±4.7 years). The mean duration of exposure to occupational hazards was 7.1±6.0 years. We included 38 cases in the program of in-depth neurophysiological examination that consisted of assessment of neurological status, electroneuromyography (ENMG). Results. 73.9 % of the cases had no complaints. Functional disorders of peripheral nerves were diagnosed as distal polyneuropathy of the upper and lower extremities (47.4 %), median neuropathy (42.1 %), ulnar neuropathy (23.7 %), and radiculopathies (9.6 %). Noteworthy is the presence of additional damages of the median nerve at the carpal tunnel in 55.6 % of the cases having signs of distal polyneuropathy. Conclusions. A comprehensive neurophysiological examination, not required by the current order for periodic medical examinations, helps to identify dysfunctions of the nervous system at their early stages. It is necessary to form high-risk groups of patients to monitor the development of work-related nervous diseases.
导言。及早发现神经系统的功能性变化,可以明确一整套不利工业因素的致病影响,形成职业病高危人群,并针对主要结构目标制定预防方案。 本研究的目的是确定暴露于职业危害的冶金工人周围神经系统功能紊乱的特征。 材料和方法。我们对两组工人进行了研究:一组是由 40 名未接触职业风险因素的男性组成的对照组,另一组是由斯维尔德洛夫斯克地区一家冶金厂的 60 名男性员工组成的病例组。两个队列的年龄(平均:38.8±7.6 岁)和工作年限(5.1±4.7 年)相匹配。接触职业危害的平均时间为 7.1±6.0 年。我们将 38 例病例纳入了深入神经电生理检查项目,其中包括神经状态评估和电神经肌电图(ENMG)。 检查结果73.9%的病例无任何不适。外周神经功能紊乱被诊断为上下肢远端多发性神经病(47.4%)、正中神经病(42.1%)、尺神经病(23.7%)和根神经病(9.6%)。值得注意的是,在有远端多发性神经病症状的病例中,有 55.6% 的病例的正中神经在腕管处受到了额外的损伤。 结论全面的神经电生理检查有助于在早期发现神经系统的功能障碍。有必要将患者组成高危群体,以监测与工作有关的神经疾病的发展。
{"title":"Functional disorders of the peripheral nervous system in metallurgical workers","authors":"E. Bakhtereva, E.L. Leiderman, T.A. Riabkova","doi":"10.47470/0016-9900-2023-102-12-1292-1296","DOIUrl":"https://doi.org/10.47470/0016-9900-2023-102-12-1292-1296","url":null,"abstract":"Introduction. Early detection of functional changes in the nervous system makes it possible to clarify the etiopathogenetic effect of a whole set of adverse industrial factors, form a group at risk of occupational diseases, and develop preventive programs for given the main structural targets. The purpose of the study was to identify characteristics of functional disorders of the peripheral nervous systems in metallurgists exposed to occupational hazards. Materials and methods. We examined two cohorts of workers: a control cohort of forty men unexposed to occupational risk factors and a case cohort of 60 male employees of a metallurgical plant situated in the Sverdlovsk Region. The cohorts were matched by age (mean: 38.8±7.6 years) and work experience (5.1±4.7 years). The mean duration of exposure to occupational hazards was 7.1±6.0 years. We included 38 cases in the program of in-depth neurophysiological examination that consisted of assessment of neurological status, electroneuromyography (ENMG). Results. 73.9 % of the cases had no complaints. Functional disorders of peripheral nerves were diagnosed as distal polyneuropathy of the upper and lower extremities (47.4 %), median neuropathy (42.1 %), ulnar neuropathy (23.7 %), and radiculopathies (9.6 %). Noteworthy is the presence of additional damages of the median nerve at the carpal tunnel in 55.6 % of the cases having signs of distal polyneuropathy. Conclusions. A comprehensive neurophysiological examination, not required by the current order for periodic medical examinations, helps to identify dysfunctions of the nervous system at their early stages. It is necessary to form high-risk groups of patients to monitor the development of work-related nervous diseases.","PeriodicalId":13009,"journal":{"name":"Hygiene and sanitation","volume":"59 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studying the ability of the food additive E171 (titanium dioxide) to induce gene mutations in bacteria 研究食品添加剂 E171(二氧化钛)诱导细菌基因突变的能力
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1361-1366
Anastasiya A. Tsareva, Olga V. Egorova, Yuliya V. Demidova, N. A. Ilyushina
Introduction. Titanium dioxide in the Russian Federation is approved for use in the food industry, in the production of medicines and hygiene products. The food additive E171 is a mixture of micro- and nanoparticles of TiO2. In 2010, IARC classified TiO2 in nanoform as a probably carcinogenic to humans (Group 2B). In vitro and in vivo studies of the genotoxicity of titanium dioxide revealed contradictory results, indicating both the presence and absence of TiO2 mutagenicity. The aim of the work is to evaluate the mutagenicity of the food additive E171 in the Ames test using standard and modified protocols. Materials and methods. The ability of food additive E171 (China) to induce reverse gene mutations in 5 strains of Salmonella typhimurium was studied under standard and modified conditions (cultivation of bacteria in the presence of methylated b-cyclodextrin (MCD) and/or pre-incubation for 1 hour in potassium phosphate buffer, pH 5.5 containing 10 mM NaCl and/or 3M MCD). Results. A sample of food additive E171 based on rutile titanium dioxide does not induce gene mutations in S. typhimurium in standard experiments. Modification of the Ames test protocol (decrease of the incubation mixture pH, addition of 10 mM NaCl) revealed statistically significant dose-dependent effects in TA100, TA98, and TA97 strains under metabolic incubation conditions. However, the fold increase of the number of revertants in the experimental plates compared to the negative control was < 2. Limitations. The research is limited to the mutagenicity assessment of food additive E171 (titanium dioxide) in the Ames test. Conclusion. The evaluation of the mutagenicity of titanium dioxide in other in vitro and in vivo tests taking into account the size and shape of the particles, is necessary to resolve the issue of its genetic safety as a food dye. A full range of studies will be performed on other samples of titanium dioxide presented in the market of the Russian Federation.
简介。俄罗斯联邦批准将二氧化钛用于食品工业、药品和卫生产品的生产。食品添加剂 E171 是二氧化钛微粒和纳米粒子的混合物。2010 年,国际癌症研究机构(IARC)将纳米形态的二氧化钛列为可能对人类致癌的物质(2B 组)。对二氧化钛的遗传毒性进行的体外和体内研究显示了相互矛盾的结果,既表明二氧化钛存在致突变性,也表明二氧化钛不存在致突变性。 这项工作的目的是采用标准和修改后的方案,在艾姆斯试验中评估食品添加剂 E171 的致突变性。 材料和方法。在标准和改进条件下(在甲基化 b-环糊精(MCD)存在下培养细菌和/或在含有 10 mM NaCl 和/或 3M MCD 的 pH 值为 5.5 的磷酸二氢钾缓冲液中预培养 1 小时),研究了食品添加剂 E171(中国)诱导 5 株鼠伤寒沙门氏菌反向基因突变的能力。 结果在标准实验中,基于金红石二氧化钛的食品添加剂 E171 样品不会诱发鼠伤寒杆菌的基因突变。在新陈代谢培养条件下,修改艾姆斯试验方案(降低培养混合液的 pH 值,添加 10 mM NaCl)对 TA100、TA98 和 TA97 菌株的影响具有统计学意义的剂量依赖性。然而,与阴性对照组相比,实验平板中逆转录酶数量的增加倍数小于 2。 局限性。研究仅限于在艾姆斯试验中对食品添加剂 E171(二氧化钛)进行诱变性评估。 结论。为了解决二氧化钛作为食品染料的基因安全性问题,有必要在其他体外和体内试验中对二氧化钛的致突变性进行评估,同时考虑到颗粒的大小和形状。将对俄罗斯联邦市场上的其他二氧化钛样品进行全面研究。
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引用次数: 0
Neurophysiological and psychological indicators of liquidators of chemical pollution of the environment 环境化学污染清理者的神经生理和心理指标
Pub Date : 2023-12-28 DOI: 10.47470/0016-9900-2023-102-12-1303-1308
E. Katamanova, D. V. Rusanova, Polina V. Kazakova
Introduction. Elimination of the consequences of emergency situations (ES) involves increased physical and psychological stress, as well as the direct aggressive impact of chemical and physical factors. Currently, the problem of environmental hazard is environmental pollution from the activities of «Usolyekhimprom», where on an area of 610 hectares there are tens of thousands of tons of harmful substances, including metallic mercury. On the territory of this enterprise, employees of the Federal Environmental Operator and the Ministry of Emergency Situations are currently engaged in eliminating environmental pollution. Over the past two years, a number of measures have been taken at the industrial site of «Usoliekhimprom» to dismantle buildings and demercurize. For 2023–2024 reconstruction, dismantling and disposal of the destroyed buildings of the enterprise are planned, in this regard, the liquidators may be affected by an even wider range of adverse factors. Employees of the East-Siberian Institute of Medical and Ecological Research conduct dynamic monitoring of the liquidators. The purpose of the study was to evaluate the neurophysiological and psychological indicators in liquidators in eliminating environmental pollution associated with the production of chemical products to prevent the occurrence of occupational pathology. Materials and methods. Forty males were examined. Electroneuromyographic examination (ENMG) was performed with testing of the sensory and motor components of the nerves of the upper extremities, electroencephalography (EEG), and psychological testing. Results. According to data of obtained ENMG parameters in the group of liquidators, a subthreshold decrease in the speed of impulse conduction in the area of the elbow joint was established during stimulation of the motor and sensory components of the ulnar nerve (up to 50 m/s). Analysis of interhemispheric coherence in the α-range in the group of liquidators revealed an increase in coherence in the right temporal leads (0.6 (0.4–0.7) G) compared with the standard values (0.35 (0.3–0.4) D) and weakening of coherent connections in the left frontal leads (0.35 (0.17–0.4) D). Changes in the mnestic sphere and the quality of life of the subjects were not revealed. Limitations. The limitation of the study was the lack of data on testing the motor and sensory components of the lower extremities during an electroneuromyographic examination and the lack of registration of evoked potentials during electroencephalography. Conclusion. The changes detected by ENMG indicate the manifestations of polyneuropathy at the preclinical stage. The analysis of interhemispheric coherence in the α-band revealed an increase in coherence in the right temporal leads and a weakening of coherent connections in the left frontal leads. The results of the medical and psychological study did not reveal any changes on the part of the mnestic sphere and the quality of life in the group of liquidators.
导言。消除紧急情况(ES)的后果包括增加身体和心理压力,以及化学和物理因素的直接侵袭。目前,环境危害问题是 "Usolyekhimprom "公司活动造成的环境污染,该公司在 610 公顷的土地上存 在着数万吨有害物质,其中包括金属汞。目前,联邦环境运营商和紧急情况部的工作人员正在该企业的领土上消除环境污染。在过去的两年中,"Usoliekhimprom "工业园区采取了一系列措施拆除建筑物和进行除险加固。计划在 2023-2024 年重建、拆除和处理企业被毁坏的建筑物,在这方面,清算人可能会受到更多不利因素的影响。东西伯利亚医学和生态研究所的员工对清算人进行了动态监测。 研究的目的是评估清算人员在消除与化工产品生产相关的环境污染时的神经生理和心理指标,以防止发生职业病。 材料和方法40 名男性接受了检查。对上肢神经的感觉和运动部分、脑电图(EEG)和心理测试进行了电神经解剖检查(ENMG)。 检查结果根据清算人组获得的 ENMG 参数数据,在刺激尺神经的运动和感觉部分时,肘关节区域的脉冲传导速度出现了阈值以下的下降(最多 50 米/秒)。对清算人组α-范围内大脑半球间连贯性的分析表明,与标准值(0.35(0.3-0.4)D)相比,右颞导联的连贯性增加了(0.6(0.4-0.7)G),而左额导联的连贯性减弱了(0.35(0.17-0.4)D)。受试者的记忆力和生活质量没有发生变化。 局限性。该研究的局限性在于缺乏在电图检查中测试下肢运动和感觉部分的数据,以及缺乏在脑电图检查中登记诱发电位的数据。 结论ENMG 检测到的变化表明多发性神经病在临床前阶段的表现。对大脑半球间α波段相干性的分析表明,右侧颞导联的相干性增强,而左侧额导联的相干性减弱。医疗和心理研究结果显示,清算人群体的心理领域和生活质量没有发生任何变化。
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引用次数: 0
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Hygiene and sanitation
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