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Ultrasensitive Detection of Creatinine Using Deep Learning-Integrated Graphene Oxide Gold Nanocomposites SERS Sensor 基于深度学习集成氧化石墨烯金纳米复合材料SERS传感器的超灵敏肌酐检测
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-09 DOI: 10.1109/LSENS.2025.3642276
Vennila Preethi Samuel;Gowri Annasamy
Creatinine, a waste product derived from protein and muscle metabolism, is a significant biomarker of kidney related diseases, with normal clinical values ranging in micromolar concentrations. The limitations of traditional kidney diagnostic modalities include the usage of more reagents, larger interference, and the requirement of expertise for diagnosis and interpretation. Recently, surface-enhanced Raman spectroscopy (SERS) has been explored for onsite detection of biomolecules with minimal sample preparation, achieving single molecule sensitivity. However, defining distinct Raman characteristic peaks from the complex structure of individual biomolecules and enhancing the weak Raman signal for single molecule detection are challenging. Therefore, this study focuses on the automated detection of creatinine using Raman spectral peaks obtained from a graphene oxide gold nanocomposite (GOAu)-coated SERS substrate. The GOAu substrate enhances the weak Raman signal, allowing for the identification of inherent peaks of creatinine at 604, 678, 836, and 904 cm−1. In addition, a deep learning feedforward neural network, utilizing rectified linear unit (ReLU) activation, was additionally employed to enable the classification and detection of ultra-low creatinine concentrations with a limit of detection (LoD) of 1 pM, where characteristic Raman peaks are not clearly distinct due to low signal-to-noise, and achieved an accuracy of 98%. This promotes the proposed sensor ultra-sensitive detection of creatinine, offering early diagnosis of kidney-related diseases.
肌酐是蛋白质和肌肉代谢产生的废物,是肾脏相关疾病的重要生物标志物,其正常临床值在微摩尔浓度范围内。传统肾脏诊断方法的局限性包括使用更多的试剂,更大的干扰,以及对诊断和解释的专业知识的要求。最近,表面增强拉曼光谱(SERS)已经被探索用于现场检测生物分子,只需最少的样品制备,实现单分子灵敏度。然而,从单个生物分子的复杂结构中定义不同的拉曼特征峰并增强单分子检测的弱拉曼信号是具有挑战性的。因此,本研究的重点是利用从氧化石墨烯金纳米复合材料(GOAu)涂层的SERS衬底中获得的拉曼光谱峰来自动检测肌酐。GOAu衬底增强了弱拉曼信号,允许在604、678、836和904 cm−1处识别肌酐的固有峰。此外,利用整流线性单元(ReLU)激活的深度学习前馈神经网络还被用于超低肌酐浓度的分类和检测,检测限(LoD)为1 pM,其中特征拉曼峰由于低信噪比而不明显,准确率达到98%。这促进了所提出的传感器超灵敏检测肌酐,提供肾脏相关疾病的早期诊断。
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引用次数: 0
Empirical Long-Term Stability of Industrial-Grade STM ISM330DHCX MEMS Inertial Sensor Calibration Parameters 工业级STM ISM330DHCX MEMS惯性传感器校准参数的经验长期稳定性
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-08 DOI: 10.1109/LSENS.2025.3641436
Alexander Kozlov;Sergey Fedorov;Fedor Kapralov
We share experimental results and statistical analysis for 36 stock ST Microelectronics ISM330DHCX industrial-grade 6-axis MEMS inertial measurement units calibration over a time span of two years. We analyze long-term variation of accelerometer and gyroscope biases, scaling and axial misalignment. Our data confirm that all error parameters remain well below specifications, and whithin them, there exist rare statistically significant long-term deviations.
我们分享了36个ST微电子ISM330DHCX工业级6轴MEMS惯性测量单元校准的实验结果和统计分析,时间跨度为两年。我们分析了加速度计和陀螺仪偏差、标度和轴向错位的长期变化。我们的数据证实,所有的误差参数仍然远远低于规范,其中,存在罕见的统计显著的长期偏差。
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引用次数: 0
Green Synthesis of CuO Porous Microflowers on PCB-Based Interdigitated Electrodes for Noninvasive Glucose Sensing 基于pcb的交叉指状电极绿色合成CuO多孔微花用于无创葡萄糖传感
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-08 DOI: 10.1109/LSENS.2025.3641837
Jitendra B. Zalke;Dinesh R. Rotake;Khushi N. Mahule;Madhura A. Ambadkar;Aditi P. Wanjari;Manashwi A. Patle;Mangesh B. Thakre
This study presents a facile green synthesis approach for developing a copper oxide (CuO) porous microflowers (PMFs) based enzymatic glucose biosensor, functionalized with ZnO nanofibers. The CuO-PMFs were synthesized using an ecofriendly method, utilizing plant extracts as reducing agents, ensuring biocompatibility and minimizing environmental impact. These CuO PMFs were then integrated with ZnO nanofibers, known for their excellent electron mobility and high surface area, to enhance the biosensor's performance. The hybrid nanomaterials were employed to immobilize glucose oxidase (GOx) enzymes, facilitating the efficient electrochemical detection of glucose on printed circuit board (PCB) based interdigitated electrodes (IDEs). The resulting biosensor was tested for its impedance change, which showed the linear range of 10–250 µM, demonstrated sensitivity of 58.131 KΩ µM−1 cm−2, a low detection limit of 117 nM, and percentage relative standard deviation of 1.56% showing good stability, making it suitable for monitoring glucose levels in biomedical applications. The green synthesis route not only contributes to sustainability but also provides a cost-effective and scalable method for fabricating high-performance biosensors, offering significant potential for noninvasive glucose monitoring in diabetic care.
本研究提出了一种简单的绿色合成方法,用于开发氧化铜(CuO)多孔微花(PMFs)为基础的酶促葡萄糖生物传感器,该传感器由ZnO纳米纤维功能化。利用植物提取物作为还原剂,采用生态友好的方法合成了CuO-PMFs,确保了生物相容性,并将对环境的影响降到最低。然后将这些CuO PMFs与ZnO纳米纤维集成,以其优异的电子迁移率和高表面积而闻名,以提高生物传感器的性能。利用该杂化纳米材料固定化葡萄糖氧化酶(GOx),实现了基于印制电路板(PCB)的交叉指状电极(IDEs)对葡萄糖的高效电化学检测。实验结果表明,该传感器的阻抗变化线性范围为10-250µM,灵敏度为58.131 KΩµM−1 cm−2,检测限为117 nM,相对标准偏差为1.56%,具有良好的稳定性,适用于生物医学领域的血糖监测。绿色合成路线不仅有助于可持续发展,而且为制造高性能生物传感器提供了一种具有成本效益和可扩展的方法,为糖尿病护理中的无创血糖监测提供了巨大的潜力。
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引用次数: 0
Failure Prediction in Manufacturing Processes Via Kullback–Leibler Divergence 基于Kullback-Leibler散度的制造过程失效预测
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-05 DOI: 10.1109/LSENS.2025.3641051
Gianluca Tabella;Mohammed Ayalew Belay;Ismael Viejo;María Herrando;Pierluigi Salvo Rossi
This work presents a novel algorithm for failure prediction in manufacturing processes using online unsupervised learning based on Kullback–Leibler divergence (KLD). The proposed method continuously monitors sensor data by comparing the probability distributions of a test window against those of a reference window to detect deviations that signal potential system degradation. These distributions are modeled as multivariate Gaussians to capture interdependencies between sensor signals. The algorithm is applied to real-world data from an electric arc furnace in the steel industry, demonstrating its ability to predict failures without prior offline training. Experimental results reveal that multivariate KLD analysis offers a more favorable balance between early fault detection and false alarm rates than univariate approaches. The method provides a lightweight, data-efficient, and practical solution for predictive maintenance in industrial settings where labeled failure data is limited or unavailable.
本文提出了一种基于Kullback-Leibler散度(KLD)的在线无监督学习的制造过程故障预测新算法。该方法通过比较测试窗口与参考窗口的概率分布来连续监测传感器数据,以检测信号潜在系统退化的偏差。这些分布被建模为多变量高斯分布,以捕获传感器信号之间的相互依赖性。该算法应用于钢铁行业电弧炉的实际数据,证明了它在没有事先离线培训的情况下预测故障的能力。实验结果表明,与单变量方法相比,多元KLD分析在早期故障检测和虚警率之间提供了更好的平衡。该方法为工业环境中标记故障数据有限或不可用的预测性维护提供了轻量级、数据高效和实用的解决方案。
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引用次数: 0
Interface-Engineered Hybrid Networks to Resolve the Trade-Off Between Sensitivity and Detection Range in Flexible Strain Sensors 基于接口工程的混合网络解决柔性应变传感器灵敏度和检测范围之间的权衡
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-03 DOI: 10.1109/LSENS.2025.3639618
Animesh Maji;Chinmoy Kuila;Naresh Chandra Murmu;Tapas Kuila
Flexible strain sensors with high sensitivity and a wide detection range are essential for next-generation healthcare and soft robotics. However, achieving a tradeoff between sensitivity and detection range is challenging in a strain sensor. This letter reports an interface engineering approach that leverages a dual conductive network to develop high-fidelity strain sensors. 3-Aminopropyltriethoxysilane, which features amine and siloxane functional groups, simultaneously binds to hybrid filler and Ecoflex. Therefore, the composite shows enhanced filler dispersion, stress transfer, and electrical signal stability under strain. This interfacial interaction enables the achievement of a sensitivity of ∼188.7 with three-zone linearity. The synergy of a dual-network conductive pathway and interfacial adhesion facilitates more repetitive cycles, resulting in a ∼75% reduction of hysteresis and a response time of approximately 450 ms. Furthermore, the high stability of >1000 cycles is attributed to the prevention of filler pullout and the maintenance of a conductive network during continuous testing. This strategy provides a scalable approach for designing next-generation flexible sensors with molecular-level interface engineering, enabling superior sensitivity, mechanical reliability, and real-time health monitoring.
具有高灵敏度和宽检测范围的柔性应变传感器对于下一代医疗保健和软机器人至关重要。然而,在应变传感器中实现灵敏度和检测范围之间的权衡是具有挑战性的。这封信报告了一种利用双导电网络开发高保真应变传感器的界面工程方法。3-氨基丙基三乙氧基硅烷,具有胺和硅氧烷官能团,同时与杂化填料和Ecoflex结合。因此,复合材料表现出增强的填料分散、应力传递和应变下的电信号稳定性。这种界面相互作用可以实现具有三区线性的~ 188.7的灵敏度。双网络导电途径和界面粘附的协同作用促进了更多的重复循环,导致滞后减少约75%,响应时间约为450 ms。此外,bbb1000循环的高稳定性归功于在连续测试期间防止填料拔出和维护导电网络。该策略为设计具有分子级界面工程的下一代柔性传感器提供了一种可扩展的方法,实现了卓越的灵敏度、机械可靠性和实时健康监测。
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引用次数: 0
Incoherent Convolutional Dictionary Learning-Based 3-D Current Reconstruction From Magnetic Field Imaging 基于非相干卷积字典学习的磁场成像三维电流重建
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-02 DOI: 10.1109/LSENS.2025.3639475
Saurabh Sahu;Prabhat Anand;Anuj Bathla;Kasturi Saha;M Girish Chandra
Accelerating the design and adoption of compact devices involving 3-D current-carrying architectures requires new and enhanced inspection methodologies to support critical device development and failure analysis. Vector magnetic field imaging with high spatio-temporal resolution is a promising approach for probing these architectures by revealing 3-D current paths. These 3-D current density maps can be obtained from magnetic field maps by solving the difficult 3-D current reconstruction problem. We present a novel incoherent convolutional dictionary learning (ICDL)-based method to process magnetic field maps acquired via nitrogen-vacancy center–based wide-field magnetic microscopy. The ICDL-based approach separates the composite magnetic field into layer-specific components within the 3-D stacked structure. Subsequently, a plug-and-play-based iterative approach jointly deconvolves each layer's magnetic field to estimate the underlying current sources. The results demonstrate an average improvement of $approx$ 2.7 dB in peak signal-to-noise ratio and $approx$ 3.7% in structural similarity index over conventional convolutional dictionary learning-based methods.
加速紧凑器件的设计和采用,包括3d载流架构,需要新的和增强的检查方法,以支持关键器件的开发和故障分析。具有高时空分辨率的矢量磁场成像通过揭示三维电流路径来探测这些结构是一种很有前途的方法。通过解决三维电流重建难题,可以从磁场图中获得三维电流密度图。我们提出了一种新的基于非相干卷积字典学习(ICDL)的方法来处理通过基于氮空位中心的宽场磁显微镜获得的磁场图。基于icdl的方法将复合磁场分离为三维堆叠结构中特定层的组件。随后,基于即插即用的迭代方法联合反卷积每层磁场,以估计底层电流源。结果表明,与传统的基于卷积字典学习的方法相比,峰值信噪比平均提高了约2.7 dB,结构相似性指数平均提高了约3.7%。
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引用次数: 0
Understanding the Nonlinear Behavior of a New z-Axis MEMS Accelerometer With In-Plane Readout 一种新型面内读出z轴MEMS加速度计的非线性特性研究
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-01 DOI: 10.1109/LSENS.2025.3638964
Yassine Banani;Christian Padovani;Giacomo Langfelder;Gabriele Gattere;Valentina Zega
This letter presents a comprehensive study of the source of nonlinearities in a novel z-axis microelectromechanical systems (MEMS) accelerometer fabricated using a two-silicon-layer fabrication process. The device features a unique mechanical architecture that converts the out-of-plane motion of the proof mass into linear in-plane displacement of the sensing frames, enabling efficient capacitive readout. Initial experimental characterization revealed an unexpected nonlinearity, exceeding predictions of the ideal mechanical model. To investigate the origin of this behavior, a detailed 3-D finite element method (FEM) analysis was performed, incorporating fabrication-induced effects such as substrate deformation and residual stresses. Simulations demonstrated that substrate deformation has negligible impact within the operational range, while residual prestresses on the structural silicon layer strongly influence the device response, producing nonlinearity levels consistent with experimental measurements. The close agreement between FEM predictions and experimental data validates the model and identifies residual prestresses on the structural silicon layer as the dominant factor affecting the device linearity. These insights provide a clear pathway for future design optimization, suggesting that careful control of residual stress and potential structural modifications can significantly improve the performance, linearity, and reliability of subsequent generations of z-axis MEMS accelerometers.
本文介绍了一种新型z轴微机电系统(MEMS)加速度计非线性源的综合研究,该加速度计采用两硅层制造工艺制造。该设备具有独特的机械结构,可将检测质量的平面外运动转换为传感框架的平面内线性位移,从而实现高效的电容读出。最初的实验表征揭示了意想不到的非线性,超出了理想力学模型的预测。为了研究这种行为的根源,进行了详细的三维有限元方法(FEM)分析,包括制造引起的影响,如基材变形和残余应力。模拟表明,衬底变形在工作范围内的影响可以忽略不计,而结构硅层上的残余预应力强烈影响器件响应,产生与实验测量一致的非线性水平。有限元预测结果与实验数据吻合较好,验证了模型的正确性,并确定了结构硅层上的残余预应力是影响器件线性度的主要因素。这些见解为未来的设计优化提供了明确的途径,表明仔细控制残余应力和潜在的结构修改可以显着提高后续几代z轴MEMS加速度计的性能,线性度和可靠性。
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引用次数: 0
Accurate Radar-Based Detection of Sleep Apnea Using Overlapping Time-Interval Averaging 基于雷达的睡眠呼吸暂停的重叠时间间隔平均精确检测
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-12-01 DOI: 10.1109/LSENS.2025.3639141
Kodai Hasegawa;Shigeaki Okumura;Hirofumi Taki;Hironobu Sunadome;Satoshi Hamada;Susumu Sato;Kazuo Chin;Takuya Sakamoto
Radar-based respiratory measurement is a promising tool for the noncontact detection of sleep apnea. Our team has reported that apnea events can be accurately detected using the statistical characteristics of the amplitude of respiratory displacement. However, apnea and hypopnea events are often followed by irregular breathing, reducing the detection accuracy. This study proposes a new method to overcome this performance degradation by repeatedly applying the detection method to radar data sets corresponding to multiple overlapping time intervals. Averaging the detected classes over multiple time intervals gives an analog value between 0 and 1, which can be interpreted as the probability of apnea and hypopnea events occurring. We show that the proposed method can mitigate the effect of irregular breathing that occurs after apnea and hypopnea events. The performance was validated using overnight recordings from seven patients, showing a 1.4-fold improvement in apnea and hypopnea event detection compared with the nonoverlapping method.
基于雷达的呼吸测量是一种很有前途的非接触检测睡眠呼吸暂停的工具。我们的团队已经报道,呼吸暂停事件可以使用呼吸位移幅度的统计特征准确地检测到。然而,呼吸暂停和低通气事件往往伴随着不规则的呼吸,降低了检测的准确性。本研究提出了一种克服这种性能下降的新方法,即对多个重叠时间间隔对应的雷达数据集重复应用该检测方法。在多个时间间隔内对检测到的类别进行平均,得到0到1之间的模拟值,这可以解释为发生呼吸暂停和呼吸不足事件的概率。我们表明,所提出的方法可以减轻呼吸暂停和低通气事件后发生的不规则呼吸的影响。使用来自7名患者的夜间记录验证了该性能,显示与非重叠方法相比,呼吸暂停和低通气事件检测改善了1.4倍。
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引用次数: 0
A Data-Driven Approach to Leak Identification and Severity Analysis in Pipelines Using Acoustic Sensing and Deep Learning 基于声学传感和深度学习的管道泄漏识别和严重程度分析数据驱动方法
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-11-28 DOI: 10.1109/LSENS.2025.3638602
Mayukh Biswas;Aditya Narayan;Debaudh Ghosh;Samriddha Ganguly;Raj Rakshit;Chirabrata Bhaumik
Gas pipeline leaks in industrial environment can be hazardous, necessitating timely remediation. Owing to the shortcomings of contact-based sensing methods, noncontact localization and diagnostics is necessary. Leak severity, alongside leak localization, is a critical parameter requiring long-term monitoring due to its nonstationary nature. Existing algorithms become computationally expensive in such conditions. Thus, a lightweight data-driven approach is necessary. It has been experimentally found that during training phase, the leak severity gets coupled with leak position due to the directional nature of a leak with respect to the sensor. This work proposes a leak-position-informed neural network training method for leak severity classification. The proposed approach has been compared with various training and testing methods to evaluate their ability to predict leak severity. The proposed method yields accuracy of 93% and 83% in clean and noisy environment over a range of experimental conditions.
工业环境下的燃气管道泄漏具有危险性,需要及时修复。由于接触式传感方法的不足,非接触式定位和诊断是必要的。泄漏严重程度和泄漏定位是一个关键参数,由于其非平稳性,需要长期监测。在这种情况下,现有的算法在计算上变得非常昂贵。因此,需要一种轻量级的数据驱动方法。实验发现,在训练阶段,由于泄漏相对于传感器的方向性,泄漏严重程度与泄漏位置耦合。本文提出了一种基于泄漏位置的泄漏严重程度分类神经网络训练方法。该方法已与各种训练和测试方法进行了比较,以评估其预测泄漏严重程度的能力。在一系列实验条件下,该方法在清洁和噪声环境下的精度分别为93%和83%。
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引用次数: 0
GYTRIX Quartz MEMS Gyro: From Concept to Northfinding Measurements GYTRIX石英MEMS陀螺:从概念到寻北测量
IF 2.2 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2025-11-28 DOI: 10.1109/LSENS.2025.3638591
O. Le Traon;J. Bonhomme;L. Hudeley;M. Duquesnoy;C. Duclos;A. Andrieux-Ledier;P. Lavenus;J. Guerard;R. Levy
This letter presents the concept of a quartz crystal Coriolis vibrating gyroscope named GYTRIX (GYro for TRIgonal piezoelectric Xtal) able to operate in matched modes using force to rebalance or in the whole angle mode. The symmetry of the design that respects quartz crystal trigonal symmetry enables two degenerated modes with nominally identical thermomechanical behavior. This new gyro concept is presented, along with the first step in its development roadmap: the design of a separated-mode open-loop gyro transducer, in order to validate the concept with existing open-loop electronics. Prototype realization and experimental measurements made it possible to validate theoretical angular random walk of 0.017°/√h and to demonstrate gyrocompass operation.
这封信介绍了一个名为GYTRIX (GYro for TRIgonal压电Xtal)的石英晶体科里奥利振动陀螺仪的概念,该陀螺仪能够在匹配模式下使用力来重新平衡或在整个角度模式下运行。设计的对称性尊重石英晶体的三角对称,使两种简并模式具有名义上相同的热力学行为。提出了这种新的陀螺仪概念,以及其发展路线图的第一步:设计一种分离模式开环陀螺仪换能器,以便与现有的开环电子设备验证该概念。样机的实现和实验测量使得理论角度随机游走0.017°/√h和陀螺罗经操作的验证成为可能。
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引用次数: 0
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IEEE Sensors Letters
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