{"title":"Academic Medical Career versus Private Medical Practice: A Guide to the Right Decision!","authors":"Samir Kahwash","doi":"10.1055/s-0043-1778046","DOIUrl":"https://doi.org/10.1055/s-0043-1778046","url":null,"abstract":"","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"59 27","pages":""},"PeriodicalIF":0.2,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul Rasak Aravessery, Maroof Raza, Mohammad Azfar
Abstract Background Schistosomiasis is a granulomatous disease prevalent in tropical and subtropical areas. Appendicitis secondary to schistosomiasis is a rarely encountered presentation, even in endemic areas. Most acute intestinal schistosomiasis presents with abdominal pain and bloody diarrhea. Other atypical clinical presentations include intestinal obstruction, peritonitis, and acute appendicitis. Case Description We report a case of a 37-year-old male from the Philippines who presented with the clinical picture of acute appendicitis and was treated with laparoscopic appendectomy. Pathological study revealed calcified Schistosomia japonicum's egg in a background of acute inflammation. Conclusion Worldwide increase in immigration and tourism resulted in an increased number of schistosomiasis in nonendemic areas. Considering this, we are faced with the uncommon etiology of acute appendicitis.
{"title":"Expecting the Unexpected: Schistosomial Appendicitis in Nonendemic Area","authors":"Abdul Rasak Aravessery, Maroof Raza, Mohammad Azfar","doi":"10.1055/s-0043-1777860","DOIUrl":"https://doi.org/10.1055/s-0043-1777860","url":null,"abstract":"Abstract Background Schistosomiasis is a granulomatous disease prevalent in tropical and subtropical areas. Appendicitis secondary to schistosomiasis is a rarely encountered presentation, even in endemic areas. Most acute intestinal schistosomiasis presents with abdominal pain and bloody diarrhea. Other atypical clinical presentations include intestinal obstruction, peritonitis, and acute appendicitis. Case Description We report a case of a 37-year-old male from the Philippines who presented with the clinical picture of acute appendicitis and was treated with laparoscopic appendectomy. Pathological study revealed calcified Schistosomia japonicum's egg in a background of acute inflammation. Conclusion Worldwide increase in immigration and tourism resulted in an increased number of schistosomiasis in nonendemic areas. Considering this, we are faced with the uncommon etiology of acute appendicitis.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"31 50","pages":""},"PeriodicalIF":0.2,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Introduction End-stage renal disease (ESRD) has become a significant problem in the North African region. There are few references about the primary causes of ESRD in kidney transplant (KT) recipients. The aim of this study was to determine the causes of the original kidney disease in KT recipients in Tripoli Central Hospital, Tripoli, Libya. Methods This is a hospital-based, retrospective descriptive study. It includes all KT recipients who were followed up in the outpatient clinic, at the Libyan National General Authority for Organ, Tissue, and Cell Transplantation and nephrology clinic in Tripoli Central Hospital during 2021, Tripoli, Libya. Results Data on 360 KT recipients were retrieved. Sixty-eight percent of the of the patients were males: 31.1% of all enrolled individuals were between 31 and 40 years. Patient mean age was 36.66 ± 11.86 years. The most common validated cause for ESRD was unknown (55.3%), followed by chronic glomerulonephritis (CGN; 15%), diabetes mellitus and systemic hypertension each equally (10.3%), congenital abnormalities (3.6%), polycystic kidney disease (3.3%), and nephrolithiasis (1.9%). Conclusion Original cause of kidney disease in most recipients was undetermined, possibly due to limited diagnostic tools or delayed presentation. However, CGN is a main known cause.
{"title":"Causes of Original Kidney Disease among Libyan Kidney Transplant Recipients","authors":"Jamila S. Elamouri, Ahmed A. Algeblawi","doi":"10.1055/s-0043-1777427","DOIUrl":"https://doi.org/10.1055/s-0043-1777427","url":null,"abstract":"Abstract Introduction End-stage renal disease (ESRD) has become a significant problem in the North African region. There are few references about the primary causes of ESRD in kidney transplant (KT) recipients. The aim of this study was to determine the causes of the original kidney disease in KT recipients in Tripoli Central Hospital, Tripoli, Libya. Methods This is a hospital-based, retrospective descriptive study. It includes all KT recipients who were followed up in the outpatient clinic, at the Libyan National General Authority for Organ, Tissue, and Cell Transplantation and nephrology clinic in Tripoli Central Hospital during 2021, Tripoli, Libya. Results Data on 360 KT recipients were retrieved. Sixty-eight percent of the of the patients were males: 31.1% of all enrolled individuals were between 31 and 40 years. Patient mean age was 36.66 ± 11.86 years. The most common validated cause for ESRD was unknown (55.3%), followed by chronic glomerulonephritis (CGN; 15%), diabetes mellitus and systemic hypertension each equally (10.3%), congenital abnormalities (3.6%), polycystic kidney disease (3.3%), and nephrolithiasis (1.9%). Conclusion Original cause of kidney disease in most recipients was undetermined, possibly due to limited diagnostic tools or delayed presentation. However, CGN is a main known cause.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"53 12","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139005994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Welcome to the fourth issue of volume 15 of the Ibnosina Journal of Medicine and Biomedical Sciences. The issue has a variety of articles, including five original articles, a case report, a personal paper, and a correspondence. In a systematic review of experimental models, Nur Nadhirah Suhaimi and colleagues examine the association between phytoestrogen consumption and female reproductive health. Hussain Alsaffar et al evaluate the medical students' attitudes toward and awareness of teaching and participation in formal clinical teaching in Iraq, while Seham Eshrif et al portray the profile of neuromuscular disorders in the neurology clinic of Tripoli Children Hospital, Tripoli, Libya. Also, Tanzeel Ur Rehman considers the immune system's responsiveness to nanomedicine during coronavirus infections through a literature review and bibliometric analysis. Finally, Maria E.M. Mariano et al assess the nursing students' learning style preferences.
欢迎阅读《伊布诺西纳医学和生物医学科学杂志》第15卷第4期。本期文章种类繁多，包括5篇原创文章、1篇个案报告、1篇个人论文和1篇书信。Nur Nadhirah Suhaimi及其同事对实验模型进行了系统回顾，研究了植物雌激素摄入与女性生殖健康之间的关系。Hussain Alsaffar等人评估了伊拉克医学生对教学的态度和意识以及对正式临床教学的参与，而Seham Eshrif等人则描述了利比亚的黎波里的黎波里儿童医院神经内科神经肌肉疾病的概况。此外，Tanzeel Ur Rehman通过文献综述和文献计量学分析，考虑了冠状病毒感染期间免疫系统对纳米药物的反应。最后，Maria E.M. Mariano等人评估了护生的学习风格偏好。
{"title":"IJMBS at the End of 2023: An Impact Factor and a New Platform","authors":"Salem A. Beshyah, Elmahdi A. Elkhammas","doi":"10.1055/s-0043-1776129","DOIUrl":"https://doi.org/10.1055/s-0043-1776129","url":null,"abstract":"Welcome to the fourth issue of volume 15 of the Ibnosina Journal of Medicine and Biomedical Sciences. The issue has a variety of articles, including five original articles, a case report, a personal paper, and a correspondence. In a systematic review of experimental models, Nur Nadhirah Suhaimi and colleagues examine the association between phytoestrogen consumption and female reproductive health. Hussain Alsaffar et al evaluate the medical students' attitudes toward and awareness of teaching and participation in formal clinical teaching in Iraq, while Seham Eshrif et al portray the profile of neuromuscular disorders in the neurology clinic of Tripoli Children Hospital, Tripoli, Libya. Also, Tanzeel Ur Rehman considers the immune system's responsiveness to nanomedicine during coronavirus infections through a literature review and bibliometric analysis. Finally, Maria E.M. Mariano et al assess the nursing students' learning style preferences.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"3 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135220902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Sigmoid volvulus (SV) is a rare form of intestinal obstruction in which the sigmoid colon twists around its own base. Endoscopic detorsion is the primary treatment in uncomplicated patients, while urgent surgery is required in the cases with bowel perforation, peritonitis, and unsuccessful endoscopic detorsion. In surgery, the gangrenous sigmoid colon is managed by resection, whereas sigmoid detorsion alone or with an additional recurrence-reducing procedure is applied in patients with viable bowel. However, the risk of recurrence following endoscopic or operative detorsion alone is as high as 90% with a risk of mortality up to 35%. To prevent or reduce SV recurrence, some selected cases require emergent or elective recurrence-preventive management including sigmoidopexy, mesopexy, mesoplasty, extraperitonealization, sigmoidectomy, and endoscopic percutaneous sigmoidopexy. However, the indications, techniques, and results of the above-mentioned procedures are controversial. In this review, the treatment options of SV and patient selection criteria for recurrence-preventive treatments are discussed.
{"title":"Management of Sigmoid Volvulus: A Literature Review","authors":"Sabri Selcuk Atamanalp, Esra Disci, Rifat Peksoz, Refik Selim Atamanalp, Cansu Tatar Atamanalp","doi":"10.1055/s-0043-1776142","DOIUrl":"https://doi.org/10.1055/s-0043-1776142","url":null,"abstract":"Abstract Sigmoid volvulus (SV) is a rare form of intestinal obstruction in which the sigmoid colon twists around its own base. Endoscopic detorsion is the primary treatment in uncomplicated patients, while urgent surgery is required in the cases with bowel perforation, peritonitis, and unsuccessful endoscopic detorsion. In surgery, the gangrenous sigmoid colon is managed by resection, whereas sigmoid detorsion alone or with an additional recurrence-reducing procedure is applied in patients with viable bowel. However, the risk of recurrence following endoscopic or operative detorsion alone is as high as 90% with a risk of mortality up to 35%. To prevent or reduce SV recurrence, some selected cases require emergent or elective recurrence-preventive management including sigmoidopexy, mesopexy, mesoplasty, extraperitonealization, sigmoidectomy, and endoscopic percutaneous sigmoidopexy. However, the indications, techniques, and results of the above-mentioned procedures are controversial. In this review, the treatment options of SV and patient selection criteria for recurrence-preventive treatments are discussed.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"397 1-3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135327421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria E.M. Mariano, Alexander Woodman, Yaser AlNaam, Lamiaa H. Al-Jamea, Rehab Y. Al-Ansari, Jenifer V. Quiambao
Abstract Objective In line with global trends, growing number of educational institutions in Saudi Arabia are developing their curricula based on the feedback and suggestions from their students to help improve the quality of teaching. This study aims to assess the differences in learning style preferences among female nursing students of Saudi Arabia. Methods This cross-sectional study included 124 female nursing students who were asked to answer the culturally adapted Arabic version of visual, aural/auditory, read/write, and kinesthetic (VARK) survey. Data were analyzed with SPSS, version 23. The Wilks' lambda or multivariate analysis (MANOVA) was used to determine the relationship between the participants' learning preferences, sociodemographic characteristics, and year of study. Results Nursing students who had visual learning preferences had a significantly different learning style as compared to those who preferred aural and kinesthetic learning (p < 0.001). On the contrary, there was not enough evidence to conclude that the same was true for students who preferred to read/write. Conclusions Further research is required to explore the relationship between learning style preferences and learning outcomes with the inclusion of a larger sample size and representatives of two genders, males and females. The findings of the current research provide the foundation for adaptive learning by identifying the individual preferences in learning among the nursing students.
{"title":"Assessment of Learning Style Preferences of Saudi Nursing Students","authors":"Maria E.M. Mariano, Alexander Woodman, Yaser AlNaam, Lamiaa H. Al-Jamea, Rehab Y. Al-Ansari, Jenifer V. Quiambao","doi":"10.1055/s-0043-1776016","DOIUrl":"https://doi.org/10.1055/s-0043-1776016","url":null,"abstract":"Abstract Objective In line with global trends, growing number of educational institutions in Saudi Arabia are developing their curricula based on the feedback and suggestions from their students to help improve the quality of teaching. This study aims to assess the differences in learning style preferences among female nursing students of Saudi Arabia. Methods This cross-sectional study included 124 female nursing students who were asked to answer the culturally adapted Arabic version of visual, aural/auditory, read/write, and kinesthetic (VARK) survey. Data were analyzed with SPSS, version 23. The Wilks' lambda or multivariate analysis (MANOVA) was used to determine the relationship between the participants' learning preferences, sociodemographic characteristics, and year of study. Results Nursing students who had visual learning preferences had a significantly different learning style as compared to those who preferred aural and kinesthetic learning (p < 0.001). On the contrary, there was not enough evidence to conclude that the same was true for students who preferred to read/write. Conclusions Further research is required to explore the relationship between learning style preferences and learning outcomes with the inclusion of a larger sample size and representatives of two genders, males and females. The findings of the current research provide the foundation for adaptive learning by identifying the individual preferences in learning among the nursing students.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136071055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The chairman finally arrived and sat down after flashing smiles at members of the medical staff in attendance. It was obvious he subscribed to the notion that leaders should never apologize for being late to a meeting with subordinates. My first meeting as an attending physician at an academic medical department was about to start. Agenda items had been distributed in a one-page written memo the day before (email was not widely available yet). The list was long, but I remember being impressed by how fast we sailed through it. Only later did I discover the secret of efficient meetings, that is, the 90/10 rule, which states that 90% of agenda items—especially thorny issues—are already discussed and decided prior to the meeting, and the remaining 10% revolves around polishing these decisions and getting a seal of approval.
{"title":"The Third Drawer","authors":"Samir Kahwash","doi":"10.1055/s-0043-1775842","DOIUrl":"https://doi.org/10.1055/s-0043-1775842","url":null,"abstract":"The chairman finally arrived and sat down after flashing smiles at members of the medical staff in attendance. It was obvious he subscribed to the notion that leaders should never apologize for being late to a meeting with subordinates. My first meeting as an attending physician at an academic medical department was about to start. Agenda items had been distributed in a one-page written memo the day before (email was not widely available yet). The list was long, but I remember being impressed by how fast we sailed through it. Only later did I discover the secret of efficient meetings, that is, the 90/10 rule, which states that 90% of agenda items—especially thorny issues—are already discussed and decided prior to the meeting, and the remaining 10% revolves around polishing these decisions and getting a seal of approval.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136293770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background Neuromuscular disorders (NMDs) are any diseases affecting the lower motor neuron (anterior horn cell, peripheral nerve, and neuromuscular junction) or muscle, all of which are components of motor unit. The aim of this study was to describe the clinical, demographic, and genetic profile of children diagnosed with different NMDs. Materials and Methods Descriptive case series study where clinical records for children with neuromuscular disorders (NMDs) how presented to the outpatient Neurology Clinic at Tripoli Children Hospital in the period from January 2015 to the date of data collection May 2023 have been reviewed to obtain the relevant information which include demographic data, parental consanguinity, family history of affected other members, diagnostic groups within NMDs used were spinal muscular atrophy (SMA) and its subtypes, Duchenne muscular dystrophy (DMD), limb girdle muscular dystrophy (LGMD) and any other NMDs, genetic testing results, ambulatory state at the time of data collection, age at death if occurred, mode of treatment (steroid for patients with diagnosis of DMD, oral Risdiplam/IV Zolgensma/intrathecal Spinraza for patients with SMA) and Genetic testing results and the eligibility to spesfic exon skipping therapy for DMD patients. Results The study revealed 53 patients with NMDs, which represent 3.8% of all neurological disorders. Of these, 32 (60.4%) were males and 21 (39.6%) were females. Patient ages ranged between 2 months and 20 years (mean = 10 years). SMA and DMD are more common than the other disorders. 77.4% of patients were have positive consanguinity and 66% are have family history. 54.7% of patients still have ability to walk independently. Four (7.5%) patients were died three of them were have diagnosis of SMA type 1 and they died before age of 18 months and the fourth who has diagnosis of SMA type 3 was die at age of 12 years. Conclusion Although neuromuscular disorders are rare as individual disease entities, as a group they are not. The retrospective study presented here could form the backbone of a future Libyan neuromuscular registry, which is necessary with many novel NMD therapies in pipeline.
{"title":"Profile of Neuromuscular Disorders: Neurology Clinic, Tripoli Children Hospital","authors":"Seham Eshrif, Suhaylah Alghareeri, Fatma BenAmer, Sondos Elsheikh","doi":"10.1055/s-0043-1772820","DOIUrl":"https://doi.org/10.1055/s-0043-1772820","url":null,"abstract":"Abstract Background Neuromuscular disorders (NMDs) are any diseases affecting the lower motor neuron (anterior horn cell, peripheral nerve, and neuromuscular junction) or muscle, all of which are components of motor unit. The aim of this study was to describe the clinical, demographic, and genetic profile of children diagnosed with different NMDs. Materials and Methods Descriptive case series study where clinical records for children with neuromuscular disorders (NMDs) how presented to the outpatient Neurology Clinic at Tripoli Children Hospital in the period from January 2015 to the date of data collection May 2023 have been reviewed to obtain the relevant information which include demographic data, parental consanguinity, family history of affected other members, diagnostic groups within NMDs used were spinal muscular atrophy (SMA) and its subtypes, Duchenne muscular dystrophy (DMD), limb girdle muscular dystrophy (LGMD) and any other NMDs, genetic testing results, ambulatory state at the time of data collection, age at death if occurred, mode of treatment (steroid for patients with diagnosis of DMD, oral Risdiplam/IV Zolgensma/intrathecal Spinraza for patients with SMA) and Genetic testing results and the eligibility to spesfic exon skipping therapy for DMD patients. Results The study revealed 53 patients with NMDs, which represent 3.8% of all neurological disorders. Of these, 32 (60.4%) were males and 21 (39.6%) were females. Patient ages ranged between 2 months and 20 years (mean = 10 years). SMA and DMD are more common than the other disorders. 77.4% of patients were have positive consanguinity and 66% are have family history. 54.7% of patients still have ability to walk independently. Four (7.5%) patients were died three of them were have diagnosis of SMA type 1 and they died before age of 18 months and the fourth who has diagnosis of SMA type 3 was die at age of 12 years. Conclusion Although neuromuscular disorders are rare as individual disease entities, as a group they are not. The retrospective study presented here could form the backbone of a future Libyan neuromuscular registry, which is necessary with many novel NMD therapies in pipeline.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136293621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanzeel Ur Rehman, Alexander Woodman, Mohammad Rasheed, Misbah Zahid
Abstract Aim Nanomedicine can play an important role in the various stages of prevention, diagnosis, treatment, vaccination, and research related to coronavirus disease 2019 (COVID-19). While nanomedicine is a powerful interdisciplinary means that offers various approaches in patient treatment, a number of factors should be critically studied to find approaches and mechanisms in the prevention, diagnosis, and treatment of this disease. This bibliometric analysis was designed to explore studies on the current knowledge of the structure, its mechanism of cell binding, and the therapeutic effect of nanomedicine on COVID-19. Methods The study data was searched from Web of Science Core Collection(WoSCC) between 2017 and 2021. Biblioshiny and VOSviewer were used to analyze and visualize patterns in scientific literature derived from WoS. Results The three clusters of keywords resulted relating to aim. Cluster 1 looking into epidemiological and public health studies on COVID-19. Cluster 2 included terms associated with virus transition, such as receptor binding, membrane glycoprotein, membrane fusion, and viral envelope proteins. Cluster 3 involved high-frequency keywords associated with nanomedicine, such as metal nanoparticles, drug delivery system doxorubicin, immunology, immune response, inflammation, and unclassified drug. Keywords such as “nanotechnology” and “gold nanoparticles” were at the center of COVID-19 related clusters, indicating the importance of these areas during the outbreak. Conclusions Understanding the advanced virology of coronaviruses and interfering with their spread through nanomedicine could significantly impact global health and economic stability. Continuous research is needed to accelerate the transfer of nanomedicine results into practice of treatment without risk of side effects.
摘要目的纳米医学可以在2019冠状病毒病(COVID-19)的预防、诊断、治疗、疫苗接种和研究的各个阶段发挥重要作用。虽然纳米医学是一种强大的跨学科手段，为患者治疗提供了各种方法，但应该对许多因素进行批判性研究，以找到预防、诊断和治疗这种疾病的方法和机制。本文献计量学分析旨在探讨纳米药物对COVID-19的结构、细胞结合机制和治疗效果的现有知识。方法检索Web of Science Core Collection(WoSCC) 2017 - 2021年的研究数据。使用Biblioshiny和VOSviewer对WoS衍生的科学文献中的模式进行分析和可视化。结果得到与目标相关的三组关键词。第1组研究COVID-19的流行病学和公共卫生研究。聚类2包括与病毒转移相关的术语，如受体结合、膜糖蛋白、膜融合和病毒包膜蛋白。聚类3涉及与纳米医学相关的高频关键词，如金属纳米颗粒、给药系统阿霉素、免疫学、免疫反应、炎症和未分类药物。“纳米技术”和“金纳米颗粒”等关键词处于新冠肺炎相关聚集性的中心，表明这些领域在疫情期间的重要性。结论了解冠状病毒的高级病毒学并通过纳米医学干预其传播将对全球健康和经济稳定产生重大影响。需要持续的研究来加速将纳米医学成果转化为无副作用风险的治疗实践。
{"title":"Responsiveness of the Immune System to Nanomedicine during Coronavirus Infections Literature Review and Bibliometric Analysis","authors":"Tanzeel Ur Rehman, Alexander Woodman, Mohammad Rasheed, Misbah Zahid","doi":"10.1055/s-0043-1775843","DOIUrl":"https://doi.org/10.1055/s-0043-1775843","url":null,"abstract":"Abstract Aim Nanomedicine can play an important role in the various stages of prevention, diagnosis, treatment, vaccination, and research related to coronavirus disease 2019 (COVID-19). While nanomedicine is a powerful interdisciplinary means that offers various approaches in patient treatment, a number of factors should be critically studied to find approaches and mechanisms in the prevention, diagnosis, and treatment of this disease. This bibliometric analysis was designed to explore studies on the current knowledge of the structure, its mechanism of cell binding, and the therapeutic effect of nanomedicine on COVID-19. Methods The study data was searched from Web of Science Core Collection(WoSCC) between 2017 and 2021. Biblioshiny and VOSviewer were used to analyze and visualize patterns in scientific literature derived from WoS. Results The three clusters of keywords resulted relating to aim. Cluster 1 looking into epidemiological and public health studies on COVID-19. Cluster 2 included terms associated with virus transition, such as receptor binding, membrane glycoprotein, membrane fusion, and viral envelope proteins. Cluster 3 involved high-frequency keywords associated with nanomedicine, such as metal nanoparticles, drug delivery system doxorubicin, immunology, immune response, inflammation, and unclassified drug. Keywords such as “nanotechnology” and “gold nanoparticles” were at the center of COVID-19 related clusters, indicating the importance of these areas during the outbreak. Conclusions Understanding the advanced virology of coronaviruses and interfering with their spread through nanomedicine could significantly impact global health and economic stability. Continuous research is needed to accelerate the transfer of nanomedicine results into practice of treatment without risk of side effects.","PeriodicalId":13067,"journal":{"name":"Ibnosina Journal of Medicine and Biomedical Sciences","volume":"208 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135648079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nur Nadhirah Suhaimi, Maisarah Nasution Waras, Nurhuda Mohamad Ansor
Abstract Phytoestrogens have been shown as promising therapeutic agents for the treatment of menopausal symptoms, osteoporosis, breast cancer, and cardiovascular diseases. However, due to its unique chemical structure, phytoestrogen may cause unintended estrogenic and/or antiestrogenic effects on the human body, especially with regard to female reproductive health and performance. Hence, this systematic review aims to provide a critical evaluation of in vitro and in vivo evidence from the literature regarding the adverse effects of phytoestrogens on female reproductive health. The literature search was performed on four electronic databases including Scopus, Science Direct, PubMed, and Google Scholar following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A total of 965 studies were screened but only 58 of them were found to be relevant and assessed for eligibility. Of these, 23 studies met the eligibility criteria while the remaining studies were excluded due to insufficiently described methods and lack of clear findings being reported. From the review, phytoestrogens may alter the development of reproductive organs, prolong the estrus cycle, induce the accumulation of fluid in the uterus, and inhibit ovulation. The concentration and exposure duration of phytoestrogens may have different effects on the reproductive organs. Thus, further studies are warranted on the toxicodynamic, toxicokinetic, mode of action, and mechanism of actions of phytoestrogens on the female reproductive system to establish recommendations regarding phytoestrogen supplement consumption for women.
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