Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4207
M. Alipour, Sedighe Yosefi, A. Pakdel, H. Sameni, V. Semnani, A. Bandegi
Chrysin is a naturally occurring bioflavonoid found in honey and propolis, with anti-cancer and anti-inflammatory properties. This study aimed to investigate the therapeutic effect of chrysin combined with 5-fluorouracil (5-FU) in the treatment of mice with colorectal cancer (CRC). Moreover, the effects of these two compounds on the expression of β -catenin and inducible nitric oxide synthase (iNOS) were investigated. The CRC was induced in the mice by azoxymethane (AOM). The co-administration of 5-FU and chrysin in the treatment of mice reduced the number of aberrant crypt foci (ACF) and the pathologic lesion percentage compared to other treatment groups ( P <0.05). The co-administration of 5-FU and chrysin resulted in a reduction in β -catenin and iNOS ( P <0.05). We showed that a combination of 5-FU and chrysin is superior to 5-FU or chrysin alone in the treatment of mice with CRC. Our approach opens an avenue to introduce a useful therapeutic option for colorectal cancer in humans.
{"title":"Enhanced efficacy of 5-fluorouracil combined with chrysin in treating colorectal cancer in BALB/c mice: Impact on β-catenin and inducible nitric oxide synthase expression","authors":"M. Alipour, Sedighe Yosefi, A. Pakdel, H. Sameni, V. Semnani, A. Bandegi","doi":"10.56042/ijnpr.v14i2.4207","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4207","url":null,"abstract":"Chrysin is a naturally occurring bioflavonoid found in honey and propolis, with anti-cancer and anti-inflammatory properties. This study aimed to investigate the therapeutic effect of chrysin combined with 5-fluorouracil (5-FU) in the treatment of mice with colorectal cancer (CRC). Moreover, the effects of these two compounds on the expression of β -catenin and inducible nitric oxide synthase (iNOS) were investigated. The CRC was induced in the mice by azoxymethane (AOM). The co-administration of 5-FU and chrysin in the treatment of mice reduced the number of aberrant crypt foci (ACF) and the pathologic lesion percentage compared to other treatment groups ( P <0.05). The co-administration of 5-FU and chrysin resulted in a reduction in β -catenin and iNOS ( P <0.05). We showed that a combination of 5-FU and chrysin is superior to 5-FU or chrysin alone in the treatment of mice with CRC. Our approach opens an avenue to introduce a useful therapeutic option for colorectal cancer in humans.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i3.5397
{"title":"Green tea as SIRT1 and SIRT3 activator in COVID-19: A molecular docking approach","authors":"","doi":"10.56042/ijnpr.v14i3.5397","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i3.5397","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134883447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i3.5520
{"title":"Antimicrobial activity of Mystroxylon aethiopicum leave extracts and isolated 3-O-acetyloleanolic acid","authors":"","doi":"10.56042/ijnpr.v14i3.5520","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i3.5520","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134884514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i1.1129
P. Maurya
In the present study, the potential role of ellagic acid on various biomarkers of oxidative stress during human ageing has been studied. The study was carried out on 75 healthy individuals of both sexes. They were divided into three age groups viz., young (<36 years; n=23; male=13, female=10), middle (36-60 years; n=38; male=25, female=13), and old (>60 years; n=14; male=8, female=6). The oxidative stress was induced by using tert -butyl hydroperoxide ( t -BHP). In each age group, erythrocytes were incubated with ellagic acid (final concentration 10 -5 M). The result demonstrated a significant ( P <0.01) decrease in total antioxidant potential in terms of FRAP value during ageing. A significant ( P <0.05) in vitro protective effect of ellagic acid on malondialdehyde and reduced glutathione levels on erythrocytes against oxidative stress induced by tert -butyl hydroperoxide has been reported. The study was performed on erythrocytes of different age groups. The findings suggest a possible role of ellagic acid as an anti-ageing compound.
{"title":"Protective effect of ellagic acid on erythrocytes subjected to oxidative stress during human ageing","authors":"P. Maurya","doi":"10.56042/ijnpr.v14i1.1129","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i1.1129","url":null,"abstract":"In the present study, the potential role of ellagic acid on various biomarkers of oxidative stress during human ageing has been studied. The study was carried out on 75 healthy individuals of both sexes. They were divided into three age groups viz., young (<36 years; n=23; male=13, female=10), middle (36-60 years; n=38; male=25, female=13), and old (>60 years; n=14; male=8, female=6). The oxidative stress was induced by using tert -butyl hydroperoxide ( t -BHP). In each age group, erythrocytes were incubated with ellagic acid (final concentration 10 -5 M). The result demonstrated a significant ( P <0.01) decrease in total antioxidant potential in terms of FRAP value during ageing. A significant ( P <0.05) in vitro protective effect of ellagic acid on malondialdehyde and reduced glutathione levels on erythrocytes against oxidative stress induced by tert -butyl hydroperoxide has been reported. The study was performed on erythrocytes of different age groups. The findings suggest a possible role of ellagic acid as an anti-ageing compound.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70704899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the current work was to synthesize, describe, and assess the antimicrobial properties of microspheres against diverse microorganisms such as Bacillus subtilis , Pseudomonas aeruginosa , and Aspergillus niger . The production of polymeric microspheres using essential oils, as well as testing the impact of such microspheres on several biological properties was carried out. The ionic gelation approach was used in the laboratory to create CEO-loaded polymeric microspheres, which were then improved for use in subsequent experiments and characterized by Particle Size Analyzer, Scanning Electron Microscopy, and Transmission Electron Microscopy. The DPPH Assay and antibacterial activities were used to enhance the study of polymeric microspheres loaded with essential oils. Additionally, to observe the per cent encapsulation efficacy, synthetic microspheres have been used. Microspheres obtained during the experimental process were in size ranging from 80 to 290 nm, depending on the amount of drugs and polymers contained. Microspheres could be spherical in shape and aggregations at specific sites, according to SEM and transmission electron microscopy. The range of encapsulation efficiency for various concentrations was 6 to 25%. By using the DPPH assay, it was observed that the antioxidant activity lies between 28 to 64%. When anti-microbial activities were performed it was observed that the incorporation of essential oils into polymers showed tremendous potential against microbes. In the current research, the essential oils-loaded polymeric microspheres showed a significant impact on a variety of microorganisms. Additionally, these microspheres exhibited noticeable radical scavenging activities. In summary, it may be claimed that certain physiochemical alterations can be used to leverage the diverse activities of these microspheres for experimental uses in the future.
{"title":"Synthesis, characterization and antibiotic capabilities of microspheres loaded with essential oils","authors":"Choudhary Asha, Salar Rani Usha, Raj Kumar, Thakur Rajesh","doi":"10.56042/ijnpr.v14i1.1130","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i1.1130","url":null,"abstract":"The purpose of the current work was to synthesize, describe, and assess the antimicrobial properties of microspheres against diverse microorganisms such as Bacillus subtilis , Pseudomonas aeruginosa , and Aspergillus niger . The production of polymeric microspheres using essential oils, as well as testing the impact of such microspheres on several biological properties was carried out. The ionic gelation approach was used in the laboratory to create CEO-loaded polymeric microspheres, which were then improved for use in subsequent experiments and characterized by Particle Size Analyzer, Scanning Electron Microscopy, and Transmission Electron Microscopy. The DPPH Assay and antibacterial activities were used to enhance the study of polymeric microspheres loaded with essential oils. Additionally, to observe the per cent encapsulation efficacy, synthetic microspheres have been used. Microspheres obtained during the experimental process were in size ranging from 80 to 290 nm, depending on the amount of drugs and polymers contained. Microspheres could be spherical in shape and aggregations at specific sites, according to SEM and transmission electron microscopy. The range of encapsulation efficiency for various concentrations was 6 to 25%. By using the DPPH assay, it was observed that the antioxidant activity lies between 28 to 64%. When anti-microbial activities were performed it was observed that the incorporation of essential oils into polymers showed tremendous potential against microbes. In the current research, the essential oils-loaded polymeric microspheres showed a significant impact on a variety of microorganisms. Additionally, these microspheres exhibited noticeable radical scavenging activities. In summary, it may be claimed that certain physiochemical alterations can be used to leverage the diverse activities of these microspheres for experimental uses in the future.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4212
{"title":"Bioactive constituents, sorption behaviour, antioxidant and antimicrobial activity of solar dried ajwain (Trachyspermum copticum L.) leaves","authors":"","doi":"10.56042/ijnpr.v14i2.4212","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4212","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4217
K. C. Garg, R. Singh
. This study makes a bibliometric assessment of the papers published in the journal from 2010 to 2020. The data was collected from the website of the journal and was analysed using MS Excel. The bibliometric assessment examines the nature and distribution of documents by their types, the geographical distribution of the papers by countries, Indian states, institutions, and authors and the impact of their productivity as reflected by the citation indicators. In addition, the trend in authorship, citations and national and international collaboration was also examined. A total of 587 documents were published during the study period, of which the majority were original research articles. Analysis revealed that during the study period, contributions from 35 countries including India were published in the journal. Maximum contributions from India were from the state of Maharashtra and Tamil Nadu. The study also found that only a small number of papers didn’t receive any citations but a substantial number of papers (17.7%) received 6-10 citations and about 1.7% of papers received 100 or more citations. Most of the highly cited papers were reviews. The multi-authored articles were predominant, whereas the least contribution was by single authors.
{"title":"A Bibliometric study of Papers Published in the Indian Journal of Natural Products and Resources during 2010-2020","authors":"K. C. Garg, R. Singh","doi":"10.56042/ijnpr.v14i2.4217","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4217","url":null,"abstract":". This study makes a bibliometric assessment of the papers published in the journal from 2010 to 2020. The data was collected from the website of the journal and was analysed using MS Excel. The bibliometric assessment examines the nature and distribution of documents by their types, the geographical distribution of the papers by countries, Indian states, institutions, and authors and the impact of their productivity as reflected by the citation indicators. In addition, the trend in authorship, citations and national and international collaboration was also examined. A total of 587 documents were published during the study period, of which the majority were original research articles. Analysis revealed that during the study period, contributions from 35 countries including India were published in the journal. Maximum contributions from India were from the state of Maharashtra and Tamil Nadu. The study also found that only a small number of papers didn’t receive any citations but a substantial number of papers (17.7%) received 6-10 citations and about 1.7% of papers received 100 or more citations. Most of the highly cited papers were reviews. The multi-authored articles were predominant, whereas the least contribution was by single authors.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4181
A. K. Dutta, P. Dutta, Bandita Pathak, Dipumoni Barman, Plabita Baruah, Deepmala Devi, J. Borah, N. Talukdar
North East (NE) India is one of the ‘biodiversity hotspots’ of the world supporting about 50% of India’s biodiversity. In the sparse to dense forests across alpine to tropical climatic conditions, the NE region has a vast distribution of medicinal plants. The present study has compiled and enlisted the wide range of medicinal plants used by different ethnic communities along with the highly traded medicinal and endemic plant species of superior quality attributes in the region. The results are derived from an extensive review of information published in different research papers including those in books, journals, public domain documents of government agencies, NGOs and business and trade databases. The number of important species used in traditional healthcare systems of the different sister states of NE India ranges from 400 to 952 and out of these, the number of different commercially promising species ranges from 7 to 14 species. Thirty-seven species of medicinal plants in NE India are identified to have importance in the national and international trade of medicinal plants and products and most of these are harvested from the wild. Despite of rich heritage and large plant diversity, the herbal drugs market of NE India has not grown at the pace observed the mainland India’s herbal drug trade. Poor infrastructure in terms of quality control and quality assurance, GLP-compliant laboratories for herbal drugs, constraints of accessibility to the region, widespread collection of the medicinal herbs from the wild coupled with lack of sustainable harvesting and package of practices for domestic cultivation of medicinal herbs are issues need to be addressed in future for exploring maximum benefit to the economy of the region from medicinal plant resources.
{"title":"Commercially important medicinal plants of North East India and their current applications – A review","authors":"A. K. Dutta, P. Dutta, Bandita Pathak, Dipumoni Barman, Plabita Baruah, Deepmala Devi, J. Borah, N. Talukdar","doi":"10.56042/ijnpr.v14i2.4181","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4181","url":null,"abstract":"North East (NE) India is one of the ‘biodiversity hotspots’ of the world supporting about 50% of India’s biodiversity. In the sparse to dense forests across alpine to tropical climatic conditions, the NE region has a vast distribution of medicinal plants. The present study has compiled and enlisted the wide range of medicinal plants used by different ethnic communities along with the highly traded medicinal and endemic plant species of superior quality attributes in the region. The results are derived from an extensive review of information published in different research papers including those in books, journals, public domain documents of government agencies, NGOs and business and trade databases. The number of important species used in traditional healthcare systems of the different sister states of NE India ranges from 400 to 952 and out of these, the number of different commercially promising species ranges from 7 to 14 species. Thirty-seven species of medicinal plants in NE India are identified to have importance in the national and international trade of medicinal plants and products and most of these are harvested from the wild. Despite of rich heritage and large plant diversity, the herbal drugs market of NE India has not grown at the pace observed the mainland India’s herbal drug trade. Poor infrastructure in terms of quality control and quality assurance, GLP-compliant laboratories for herbal drugs, constraints of accessibility to the region, widespread collection of the medicinal herbs from the wild coupled with lack of sustainable harvesting and package of practices for domestic cultivation of medicinal herbs are issues need to be addressed in future for exploring maximum benefit to the economy of the region from medicinal plant resources.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4219
{"title":"Saponin, total tannin, and anthraquinone contents in Alhagi maurorum from the Rajasthan desert","authors":"","doi":"10.56042/ijnpr.v14i2.4219","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4219","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i3.4626
This study attempts to determine the effect of drying and extraction methods on the antioxidant capacity, phenolic compounds, and betalain pigment of Alternanthera sessilis red. Evaluation of extraction yield showed that superheated steam drying exhibited a higher yield than freeze drying. A combination of superheated steam drying and ultrasonic-assisted extraction resulted in the highest 2,2-Diphenyl-1-picrylhydrazyl radical scavenging activity (39.48%). Ferric reducing antioxidant power analysis revealed that ultrasonic-assisted extraction enhanced the antioxidant capacity (878.86 mg Trolox equivalents/100g dried sample) of freeze-dried Alternanthera sessilis red on par with superheated steam dried sample. The increase in the concentration of major phenolic compounds was also reported in all superheated steam drying samples (gallic acid: 1556.98 -1715.75 mg/100 g dried sample; vanillic acid: 217.21 - 230.41 mg/100 g dried sample; p-coumaric acid: 1422.10 – 1559.96 mg/100 g dried sample). As for betalain pigment, superheated steam drying caused its degradation but the impact was reduced after combination with ultrasonic-assisted extraction (betanin : 9.77 mg/100 g dried sample; betaxanthin: 9.07 mg/100 g dried sample). The present result showed that superheated steam drying enhanced the extraction yield, antioxidant capacity and concentration of phenolic compounds of Alternanthera sessilis red, regardless of the extraction method.
{"title":"Impact of drying and extraction method on antioxidant capacity, phenolic compounds and betalain pigment of Alternanthera sessilis red","authors":"","doi":"10.56042/ijnpr.v14i3.4626","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i3.4626","url":null,"abstract":"This study attempts to determine the effect of drying and extraction methods on the antioxidant capacity, phenolic compounds, and betalain pigment of Alternanthera sessilis red. Evaluation of extraction yield showed that superheated steam drying exhibited a higher yield than freeze drying. A combination of superheated steam drying and ultrasonic-assisted extraction resulted in the highest 2,2-Diphenyl-1-picrylhydrazyl radical scavenging activity (39.48%). Ferric reducing antioxidant power analysis revealed that ultrasonic-assisted extraction enhanced the antioxidant capacity (878.86 mg Trolox equivalents/100g dried sample) of freeze-dried Alternanthera sessilis red on par with superheated steam dried sample. The increase in the concentration of major phenolic compounds was also reported in all superheated steam drying samples (gallic acid: 1556.98 -1715.75 mg/100 g dried sample; vanillic acid: 217.21 - 230.41 mg/100 g dried sample; p-coumaric acid: 1422.10 – 1559.96 mg/100 g dried sample). As for betalain pigment, superheated steam drying caused its degradation but the impact was reduced after combination with ultrasonic-assisted extraction (betanin : 9.77 mg/100 g dried sample; betaxanthin: 9.07 mg/100 g dried sample). The present result showed that superheated steam drying enhanced the extraction yield, antioxidant capacity and concentration of phenolic compounds of Alternanthera sessilis red, regardless of the extraction method.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135212544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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