Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4210
L. Hai, Trieu, Dao Dang Nhu Quynh, Nguyen Thi Kim, Oanh, Lam Bich Thao, N. Minh, Khoi, Tran Ba Hieu, L. Minh
Developing products derived from medicinal herbs with wound-healing effects has been a current trend. This study was set up to observe the wound healing efficiency of herbal preparations formulated from M. citrifolia leaf extract on mice. The wound healing activity of cream, ointment, and powder preparations containing Noni leaf extract of 1% and 5% ( w/w ) was investigated on the excision wound model. The potential preparation was continuously evaluated for rabbit skin irritation, antioxidant activity, total flavonoid, and rutin contents. Results revealed that the topical application of Noni leaf extract preparations treated groups increased remarkably wound contraction during 11 days of treatment. A cream containing 1% extract not only had the ability to significantly reduce the size of the wound but also regenerated the structure of the skin histology at the wound area. Moreover, the cream showed safety following an acute dermal irritation study on rabbits as well as an antioxidant effect via inhibition of DPPH and ABTS free radicals. The present study also identified the content of total flavonoids and rutin markers in the cream. This research affirms the topical application of the cream containing M. citrifolia leaf extract as a known wound healing factor from traditional medicine.
{"title":"Wound-healing potential of topical application of preparations from Noni (Morinda citrifolia L.) leaf extract","authors":"L. Hai, Trieu, Dao Dang Nhu Quynh, Nguyen Thi Kim, Oanh, Lam Bich Thao, N. Minh, Khoi, Tran Ba Hieu, L. Minh","doi":"10.56042/ijnpr.v14i2.4210","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4210","url":null,"abstract":"Developing products derived from medicinal herbs with wound-healing effects has been a current trend. This study was set up to observe the wound healing efficiency of herbal preparations formulated from M. citrifolia leaf extract on mice. The wound healing activity of cream, ointment, and powder preparations containing Noni leaf extract of 1% and 5% ( w/w ) was investigated on the excision wound model. The potential preparation was continuously evaluated for rabbit skin irritation, antioxidant activity, total flavonoid, and rutin contents. Results revealed that the topical application of Noni leaf extract preparations treated groups increased remarkably wound contraction during 11 days of treatment. A cream containing 1% extract not only had the ability to significantly reduce the size of the wound but also regenerated the structure of the skin histology at the wound area. Moreover, the cream showed safety following an acute dermal irritation study on rabbits as well as an antioxidant effect via inhibition of DPPH and ABTS free radicals. The present study also identified the content of total flavonoids and rutin markers in the cream. This research affirms the topical application of the cream containing M. citrifolia leaf extract as a known wound healing factor from traditional medicine.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4216
S. Selvi, Funda Akçay, Koç, Fatih Sat ı l
In this study, the medicinal plants used in the treatment of livestock diseases by the rural people living in Ayval ı k district (Bal ı kesir) were determined. In addition, how and for what purposes these plants are used was investigated. A total of 50 informants such as breeders, shepherds and farmers were selected randomly for the study. Data were collected through semi-structured interview, focus group discussions, observation and guided field walk with informants. The collected data were analyzed through RFC, ICF, UV, FL, PPV and FUV. A total of 46 taxa of plants distributed in 44 genera belonging to 25 families were identified as commonly used ethnomedicinal for livestock diseases. The most cited families were Hypericaceae (FUV = 0.7), Oleaceae (FUV = 0.6), Pinaceae (FUV = 0.4) and Amaryllidaceae (FUV = 0.35). The majority of the remedies were prepared from infusion (53.9%). Leaves were the most frequently used plant part (PPV 0.31) and Hypericum perforatum subsp. veronense (UV) was the species most commonly prescribed by local people. The reported ailments were classified into 11 disease categories based on ICF values and the highest number of plant taxa was reported to treat gastrointestinal, lactation, dermatological and parasitic disorders. The results of this study showed that people living in the Ayval ı k district are still dependent on medicinal and aromatic plants for animal diseases. The documented plants can serve as a basis for further studies on the region’s medicinal plants knowledge and for future phytochemical and pharmacological studies.
{"title":"An ethnoveterinary study on plants used for in the treatment of livestock diseases in Ayvalık (Balıkesir, Turkey)","authors":"S. Selvi, Funda Akçay, Koç, Fatih Sat ı l","doi":"10.56042/ijnpr.v14i2.4216","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4216","url":null,"abstract":"In this study, the medicinal plants used in the treatment of livestock diseases by the rural people living in Ayval ı k district (Bal ı kesir) were determined. In addition, how and for what purposes these plants are used was investigated. A total of 50 informants such as breeders, shepherds and farmers were selected randomly for the study. Data were collected through semi-structured interview, focus group discussions, observation and guided field walk with informants. The collected data were analyzed through RFC, ICF, UV, FL, PPV and FUV. A total of 46 taxa of plants distributed in 44 genera belonging to 25 families were identified as commonly used ethnomedicinal for livestock diseases. The most cited families were Hypericaceae (FUV = 0.7), Oleaceae (FUV = 0.6), Pinaceae (FUV = 0.4) and Amaryllidaceae (FUV = 0.35). The majority of the remedies were prepared from infusion (53.9%). Leaves were the most frequently used plant part (PPV 0.31) and Hypericum perforatum subsp. veronense (UV) was the species most commonly prescribed by local people. The reported ailments were classified into 11 disease categories based on ICF values and the highest number of plant taxa was reported to treat gastrointestinal, lactation, dermatological and parasitic disorders. The results of this study showed that people living in the Ayval ı k district are still dependent on medicinal and aromatic plants for animal diseases. The documented plants can serve as a basis for further studies on the region’s medicinal plants knowledge and for future phytochemical and pharmacological studies.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4202
{"title":"Ethnomedicinal, phytochemical and pharmacological properties of Pogostemon heyneanus Benth: A review","authors":"","doi":"10.56042/ijnpr.v14i2.4202","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4202","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i3.4612
The efficient cutaneous wound healing process constitutes a critical challenge for clinical and fundamental research. Indeed, agents that prevent bacterial infections, the excessive production of free radicals, and inflammation may enhance wound healing. In this context, the biological activities of the methanolic extract prepared from the species Suaeda monodiana Maire were assessed. The antioxidant activity was tested by five different methods, and the sun protection factor was measured. The hemostatic activity was evaluated by determining plasma re-calcification time, and the anti-inflammatory effect was carried out by heat-inducing hemolysis and albumin denaturation tests. The antimicrobial activity was evaluated by the agar disk diffusion assay against seven strains. As a result, the tested extract has a rich chemical composition and possesses interesting photoprotective (SPF at 46.49±0.05) and antioxidant activities. This extract showed the ability to inhibit protein denaturation (IC50 at 1.22±0.8 mg/mL) and to protect the erythrocytes membrane (IC50 at 2.39±0.3 mg/mL). Moreover, the Methanol extract significantly shortens the clotting time and inhibits the growth of all the tested strains with minimum inhibitory concentrations ranging between 31.25 to 250 µg/mL. Furthermore, due to its pharmacological properties, S. monodiana species could be used in pharmaceutical formulations for the treatment of skin diseases.
{"title":"Assessment of in vitro anti-inflammatory, hemostatic, antimicrobial, photoprotective and antioxidant activities of the Algerian species Suaeda monodiana","authors":"","doi":"10.56042/ijnpr.v14i3.4612","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i3.4612","url":null,"abstract":"The efficient cutaneous wound healing process constitutes a critical challenge for clinical and fundamental research. Indeed, agents that prevent bacterial infections, the excessive production of free radicals, and inflammation may enhance wound healing. In this context, the biological activities of the methanolic extract prepared from the species Suaeda monodiana Maire were assessed. The antioxidant activity was tested by five different methods, and the sun protection factor was measured. The hemostatic activity was evaluated by determining plasma re-calcification time, and the anti-inflammatory effect was carried out by heat-inducing hemolysis and albumin denaturation tests. The antimicrobial activity was evaluated by the agar disk diffusion assay against seven strains. As a result, the tested extract has a rich chemical composition and possesses interesting photoprotective (SPF at 46.49±0.05) and antioxidant activities. This extract showed the ability to inhibit protein denaturation (IC50 at 1.22±0.8 mg/mL) and to protect the erythrocytes membrane (IC50 at 2.39±0.3 mg/mL). Moreover, the Methanol extract significantly shortens the clotting time and inhibits the growth of all the tested strains with minimum inhibitory concentrations ranging between 31.25 to 250 µg/mL. Furthermore, due to its pharmacological properties, S. monodiana species could be used in pharmaceutical formulations for the treatment of skin diseases.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i3.4588
Ghee, a clarified butter commonly used in Indian cuisine for centuries. Both beneficial and harmful effects of ghee on health are found in many research works, and it creates more confusion about the intake of ghee and its effect on health. To overcome this confusion, it was decided to conduct a systematic review of experimental studies (In vivo) to synthesize available information on the oral intake of Ghee and its effect on lipid profile and other parameters. Twenty in vivo studies were identified, conducted in animals, and published between 1960 and 2020. The published research quality was assessed using ARRIVE guidelines and SYRCLE’s risk of Bias tool. Three of the 20 experiments were not included in the present study as they don't have abstracts, full papers, or free access to full papers. Source of milk fat (cow/ buffalo), method of preparation (cream/curd starter or traditional/modern) and form of usage (plain/fried - oxidized) alters the composition of ghee, which affects its effect on Lipid profile (TC, TG, HDL, LDL) and other parameters. The use of ghee, along with other fatty substances, may reduce the unhealthy effects of other plain or fried oils. Quantity (5, 10, and 20% of total calories) and duration (28, 60, 90, 120, and 270 days) of ghee affect lipid profile and other parameters differently.
{"title":"Effect of Ghee (Clarified Butter) intake on Lipid profile: A systematic review on animal experiments","authors":"","doi":"10.56042/ijnpr.v14i3.4588","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i3.4588","url":null,"abstract":"Ghee, a clarified butter commonly used in Indian cuisine for centuries. Both beneficial and harmful effects of ghee on health are found in many research works, and it creates more confusion about the intake of ghee and its effect on health. To overcome this confusion, it was decided to conduct a systematic review of experimental studies (In vivo) to synthesize available information on the oral intake of Ghee and its effect on lipid profile and other parameters. Twenty in vivo studies were identified, conducted in animals, and published between 1960 and 2020. The published research quality was assessed using ARRIVE guidelines and SYRCLE’s risk of Bias tool. Three of the 20 experiments were not included in the present study as they don't have abstracts, full papers, or free access to full papers. Source of milk fat (cow/ buffalo), method of preparation (cream/curd starter or traditional/modern) and form of usage (plain/fried - oxidized) alters the composition of ghee, which affects its effect on Lipid profile (TC, TG, HDL, LDL) and other parameters. The use of ghee, along with other fatty substances, may reduce the unhealthy effects of other plain or fried oils. Quantity (5, 10, and 20% of total calories) and duration (28, 60, 90, 120, and 270 days) of ghee affect lipid profile and other parameters differently.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i3.4696
In the present study, the antifungal activity of a West Himalayan bryophyte Atrichum undulatum in different solvents (butanol, ethanol, methanol and aqueous) has been evaluated by agar well diffusion assay against six fungal strains (Candida albicans, C. glabrata, C. tropicalis, C. parapsilosis, Issatchenkia orientalis and Kluyveromyces marxianus). Among all the extracts, butanol extract showed potent antifungal activity against I. orientalis, K. marxianus, C. parapsilosis and C. tropicalis followed by ethanol and methanol extract. Fungal cells treated with butanol extract showed cell wall damage under scanning electron microscopy and confocal microscopy. GC-MS and FTIR analysis showed the presence of bioactive compounds which act as antimicrobial agents. The results support the traditional use of A. undulatum as an antimicrobial agent. The present research records for the first time the morphological alterations of fungal cells by the butanol extract of A. undulatum alone and synergistically with the antibiotic Amphotericin B (Amp B).
{"title":"Antifungal activity, phytochemical analysis and mode of action of Atrichum undulatum (Hedw.) P. Beauv.","authors":"","doi":"10.56042/ijnpr.v14i3.4696","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i3.4696","url":null,"abstract":"In the present study, the antifungal activity of a West Himalayan bryophyte Atrichum undulatum in different solvents (butanol, ethanol, methanol and aqueous) has been evaluated by agar well diffusion assay against six fungal strains (Candida albicans, C. glabrata, C. tropicalis, C. parapsilosis, Issatchenkia orientalis and Kluyveromyces marxianus). Among all the extracts, butanol extract showed potent antifungal activity against I. orientalis, K. marxianus, C. parapsilosis and C. tropicalis followed by ethanol and methanol extract. Fungal cells treated with butanol extract showed cell wall damage under scanning electron microscopy and confocal microscopy. GC-MS and FTIR analysis showed the presence of bioactive compounds which act as antimicrobial agents. The results support the traditional use of A. undulatum as an antimicrobial agent. The present research records for the first time the morphological alterations of fungal cells by the butanol extract of A. undulatum alone and synergistically with the antibiotic Amphotericin B (Amp B).","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135212789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i1.1137
Prabha Arya, Kamana Singh, Divya Sharma, M. Dhobi, Kamal Kumar Gupta, Indrakant K Singh, V. Nissapatorn, Ram Sunil Kumar, Jyoti Kayesth, Sunil Kayesth
Compared to allopathic medicines or chemically synthesized drugs, there is a growing use of natural compounds and supplements in herbal medicine to treat various diseases as they are safe and devoid of side effects. Though, this is not completely true as many cases of the detrimental impact of herbal or traditional medicine have been reported. Herbal medicines contain unpurified plant portions or extracts which may have these side effects. How effective are the drug molecules derived from natural products, or how destructive are the undesirable compounds that must be investigated? Natural extracts are mixtures of various components, and there is uncertainty about the mechanism of action of certain herbal medicines. There may be a lot of factors involved like placebo effects, and other molecules without which medicine may not work in isolation. In this study, we have reviewed the effects of herbal medicines, possible causes for their benefits like epigenetic changes, adverse drug reactions, and the provision to control these issues. We have also explored the measures being taken at the national and international levels. There have been efforts to minimize the issues related to side effects based on reporting from the population using remedies monitored by pharmacovigilance.
{"title":"Herbal and traditional medicines pharmacovigilance for holistic treatment","authors":"Prabha Arya, Kamana Singh, Divya Sharma, M. Dhobi, Kamal Kumar Gupta, Indrakant K Singh, V. Nissapatorn, Ram Sunil Kumar, Jyoti Kayesth, Sunil Kayesth","doi":"10.56042/ijnpr.v14i1.1137","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i1.1137","url":null,"abstract":"Compared to allopathic medicines or chemically synthesized drugs, there is a growing use of natural compounds and supplements in herbal medicine to treat various diseases as they are safe and devoid of side effects. Though, this is not completely true as many cases of the detrimental impact of herbal or traditional medicine have been reported. Herbal medicines contain unpurified plant portions or extracts which may have these side effects. How effective are the drug molecules derived from natural products, or how destructive are the undesirable compounds that must be investigated? Natural extracts are mixtures of various components, and there is uncertainty about the mechanism of action of certain herbal medicines. There may be a lot of factors involved like placebo effects, and other molecules without which medicine may not work in isolation. In this study, we have reviewed the effects of herbal medicines, possible causes for their benefits like epigenetic changes, adverse drug reactions, and the provision to control these issues. We have also explored the measures being taken at the national and international levels. There have been efforts to minimize the issues related to side effects based on reporting from the population using remedies monitored by pharmacovigilance.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i1.1140
{"title":"GCMS analysis and mosquitocidal effects of petroleum ether extract of Datura stramonium and Morus alba against Aedes aegypti","authors":"","doi":"10.56042/ijnpr.v14i1.1140","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i1.1140","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.4213
{"title":"Pharmacognostical, physicochemical, and phytochemical investigation of Allium wallichii Kunth (An unexplored and underutilised traditional aromatic plant from Himalayan regions)","authors":"","doi":"10.56042/ijnpr.v14i2.4213","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.4213","url":null,"abstract":"","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.56042/ijnpr.v14i2.1161
S. Bhattacharya
Medicinal plants have duly been implicated in the development of typical antineoplastic agents. Here, the medicinal plant under discourse, Trichosanthes dioica Roxb., commonly known as Pointed gourd in English, Potol in Bengali, is a climber vine found wild and cultivated all over the plains of India and its neighbouring countries for its fruits, consumed as a favoured vegetable. The present work attempts to assemble and critically assess the literature outcome of the antineoplastic potential of T. dioica root. The antineoplastic effects involved cytotoxic, antimitotic, antitumor and cancer chemopreventive potential of its root - mediated through multifaceted mechanisms. The cytotoxic, antimitoitic and antioxidant effects together may furnish the mechanistic grounds for its reported antitumor and cancer chemopreventive activities. Further studies on T. dioica root in this direction, may afford newer effective antitumor leads/drugs from this plant part.
{"title":"Antineoplastic potential of Trichosanthes dioica Root: A treatise","authors":"S. Bhattacharya","doi":"10.56042/ijnpr.v14i2.1161","DOIUrl":"https://doi.org/10.56042/ijnpr.v14i2.1161","url":null,"abstract":"Medicinal plants have duly been implicated in the development of typical antineoplastic agents. Here, the medicinal plant under discourse, Trichosanthes dioica Roxb., commonly known as Pointed gourd in English, Potol in Bengali, is a climber vine found wild and cultivated all over the plains of India and its neighbouring countries for its fruits, consumed as a favoured vegetable. The present work attempts to assemble and critically assess the literature outcome of the antineoplastic potential of T. dioica root. The antineoplastic effects involved cytotoxic, antimitotic, antitumor and cancer chemopreventive potential of its root - mediated through multifaceted mechanisms. The cytotoxic, antimitoitic and antioxidant effects together may furnish the mechanistic grounds for its reported antitumor and cancer chemopreventive activities. Further studies on T. dioica root in this direction, may afford newer effective antitumor leads/drugs from this plant part.","PeriodicalId":13297,"journal":{"name":"Indian Journal of Natural Products and Resources","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70705206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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