Pub Date : 2019-09-30DOI: 10.30516/bilgesci.582054
H. Canbay, M. Polat, Mahmut Doğantürk
Abstract: Estriol , is a major urinary estrogen hormone . Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy ( FTIR ) were used to assess the compatibility between estriol and drug excipients (1:1; w/w). In this study, thermodynamic and spectroscopic data obtained from pure estriol and mixtures of pure estriol with pharmaceutical excipients were compared. Preliminary studies using thermal and spectroscopic technique implied the compatibility of mannitol, calcium phosphate dibasic, sucrose, butylated hydroxyanisole, cellulose, lactose, magnesium stearate, talc and sodium carboxymethyl cellulose with the drug estriol. As a result of the experimental study, there is incompatibility of estriol-mannitol, estriol-sucrose, estriol-lactose and estriol-magnesium stearate . Keywords Estriol, Stability Compatibility, DSC, FTIR
{"title":"Study of Stability and Drug-Excipient Compatibility of Estriol","authors":"H. Canbay, M. Polat, Mahmut Doğantürk","doi":"10.30516/bilgesci.582054","DOIUrl":"https://doi.org/10.30516/bilgesci.582054","url":null,"abstract":"Abstract: Estriol , is a major urinary estrogen hormone . Differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy ( FTIR ) were used to assess the compatibility between estriol and drug excipients (1:1; w/w). In this study, thermodynamic and spectroscopic data obtained from pure estriol and mixtures of pure estriol with pharmaceutical excipients were compared. Preliminary studies using thermal and spectroscopic technique implied the compatibility of mannitol, calcium phosphate dibasic, sucrose, butylated hydroxyanisole, cellulose, lactose, magnesium stearate, talc and sodium carboxymethyl cellulose with the drug estriol. As a result of the experimental study, there is incompatibility of estriol-mannitol, estriol-sucrose, estriol-lactose and estriol-magnesium stearate . Keywords Estriol, Stability Compatibility, DSC, FTIR","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126307644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.30516/bilgesci.591236
Mehmet Güvenç Negiz, Kadir Çınar, Esra Özge Aygül
In this study was carried out in Yenisarbademli region in order to determine the relationship between Black Pine productivity and distribution and the environmental factors. The data of the study were obtained from 70 sample areas selected from the areas where Black Pine species is naturally found in the region. The relationships between the productivity of Black Pine and environmental factors were investigated by Pearson and Spearman Correlation analysis. Multiple regression analysis was used in the modeling of the efficiency of Black Pine species. Correlation analysis showed a positive correlation between elevation, lower slope, and flat ground. A negative correlation was found with slope and ruggedness variables. Similarly, the productivity model of the species, elevation, lower slope, and flat terrain were formed. The results obtained from the study will contribute to the ecological studies to be carried out in the whole country and in the world-wide Black Pine species, especially in the forest areas of Yenisarbademli, and to implement the future plantation and conservation plans.
{"title":"KARAÇAM (Pinus nigra) TÜRÜNÜN VERİMLİLİK VE DAĞILIM ÖZELLİKLERİ ÜZERİNE EKOLOJİK DEĞERLENDİRMELER: ISPARTA-YENİŞARBADEMLİ ÖRNEĞİ","authors":"Mehmet Güvenç Negiz, Kadir Çınar, Esra Özge Aygül","doi":"10.30516/bilgesci.591236","DOIUrl":"https://doi.org/10.30516/bilgesci.591236","url":null,"abstract":"In this study was carried out in Yenisarbademli region in order to determine the relationship between Black Pine productivity and distribution and the environmental factors. The data of the study were obtained from 70 sample areas selected from the areas where Black Pine species is naturally found in the region. The relationships between the productivity of Black Pine and environmental factors were investigated by Pearson and Spearman Correlation analysis. Multiple regression analysis was used in the modeling of the efficiency of Black Pine species. Correlation analysis showed a positive correlation between elevation, lower slope, and flat ground. A negative correlation was found with slope and ruggedness variables. Similarly, the productivity model of the species, elevation, lower slope, and flat terrain were formed. The results obtained from the study will contribute to the ecological studies to be carried out in the whole country and in the world-wide Black Pine species, especially in the forest areas of Yenisarbademli, and to implement the future plantation and conservation plans.","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126707045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.30516/bilgesci.405074
Ahmet Efe, Büşra Tuzlupınar, Ahmet Can Cavlan
Air Traffic Management (ATM) security is amongst major topics of safety critical systems and issues of both civil aviation and military defense units. The dramatic increase in the number of the aircrafts and the innovative technology that provides smaller and sustainable air vehicles make the air communication protocols and methods as a high profile potential target for black hat hackers. There are lots of communication protocols and different systems between air to ground (A2G) station and air to air (A2A). These include set of information such as aircraft communication data, voice information and flight planning which works on some protocols. All of radar detection and chasing systems are also using similar techniques. The Data Distribution Service (DDS) is a protocol for data transfer to each node. The communication systems can be protected from third party system or hackers to some extent. The security is coming from that point. Each components have own security using valid and standard methods. Our approach in this study, enforces reasonable and applicable security concepts and techniques for a robust and resillient air traffic.
{"title":"Air Traffic Security","authors":"Ahmet Efe, Büşra Tuzlupınar, Ahmet Can Cavlan","doi":"10.30516/bilgesci.405074","DOIUrl":"https://doi.org/10.30516/bilgesci.405074","url":null,"abstract":"Air Traffic Management (ATM) security is amongst major topics of safety critical systems and issues of both civil aviation and military defense units. The dramatic increase in the number of the aircrafts and the innovative technology that provides smaller and sustainable air vehicles make the air communication protocols and methods as a high profile potential target for black hat hackers. There are lots of communication protocols and different systems between air to ground (A2G) station and air to air (A2A). These include set of information such as aircraft communication data, voice information and flight planning which works on some protocols. All of radar detection and chasing systems are also using similar techniques. The Data Distribution Service (DDS) is a protocol for data transfer to each node. The communication systems can be protected from third party system or hackers to some extent. The security is coming from that point. Each components have own security using valid and standard methods. Our approach in this study, enforces reasonable and applicable security concepts and techniques for a robust and resillient air traffic.","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131011153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.30516/bilgesci.616084
Halil Suel
{"title":"Interaction of Wildboar (Sus scrofa) with Some Mammal Species in Sütçüler Distirct","authors":"Halil Suel","doi":"10.30516/bilgesci.616084","DOIUrl":"https://doi.org/10.30516/bilgesci.616084","url":null,"abstract":"","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125076508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-30DOI: 10.30516/bilgesci.596084
A. Küçükosmanoğlu, Çağdan Uyar, Gülberk Gizem Küçükosmanoğlu
Considering our world as a whole, prevention of potential hazards and problems is possible by protecting natural resources in harmony with each other and ensuring natural balance. Therefore, conservation of biodiversity and natural resources is primarily a guarantee of the continuity of life on earth and a prerequisite of meeting the sustainable development needs of societies. Illegal hunting practices that have been performed in Turkey for many years have led to a decrease in the number of wild animals or complete extinction of them. The Land Hunting Law No. 4915, which entered into force in 2003 in accordance with its counterparts in the world, contains provisions on the conservation of wild animals and their habitats against a variety of factors (legal basis). There are international biodiversity conventions to which Turkey is also a party. These conventions are critical in terms of conservation and sustainability of biological diversity. The ‘Noah’s Ark National Biodiversity Database’ implemented in Turkey in accordance with these conventions is one of the critical projects in this field. This project has gained importance for the conservation and sustainability of biodiversity both in the world and Turkey. The study includes the main headings of Introduction, Materials and Methods, Findings, and Conclusions and Recommendations, and the sub-headings of Protected Areas, Protected Areas in Turkey, and Studies on Biodiversity. The Conclusion and Recommendations section contains recommendations to preserve habitat and species diversity for biodiversity conservation and emphasizes the importance and framework of national and global conventions to date. Solutions were produced through a holistic assessment.
{"title":"An Investigation of the Studies on the Conservation of Biodiversity in Turkey","authors":"A. Küçükosmanoğlu, Çağdan Uyar, Gülberk Gizem Küçükosmanoğlu","doi":"10.30516/bilgesci.596084","DOIUrl":"https://doi.org/10.30516/bilgesci.596084","url":null,"abstract":"Considering our world as a whole, prevention of potential hazards and problems is possible by protecting natural resources in harmony with each other and ensuring natural balance. Therefore, conservation of biodiversity and natural resources is primarily a guarantee of the continuity of life on earth and a prerequisite of meeting the sustainable development needs of societies. Illegal hunting practices that have been performed in Turkey for many years have led to a decrease in the number of wild animals or complete extinction of them. The Land Hunting Law No. 4915, which entered into force in 2003 in accordance with its counterparts in the world, contains provisions on the conservation of wild animals and their habitats against a variety of factors (legal basis). There are international biodiversity conventions to which Turkey is also a party. These conventions are critical in terms of conservation and sustainability of biological diversity. The ‘Noah’s Ark National Biodiversity Database’ implemented in Turkey in accordance with these conventions is one of the critical projects in this field. This project has gained importance for the conservation and sustainability of biodiversity both in the world and Turkey. The study includes the main headings of Introduction, Materials and Methods, Findings, and Conclusions and Recommendations, and the sub-headings of Protected Areas, Protected Areas in Turkey, and Studies on Biodiversity. The Conclusion and Recommendations section contains recommendations to preserve habitat and species diversity for biodiversity conservation and emphasizes the importance and framework of national and global conventions to date. Solutions were produced through a holistic assessment.","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128016916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.30516/BILGESCI.536101
H. Süel, Y. Ünal, Serkan Özdemir, A. Koca
The wild goat ( Capra aegagrus ) has a very widespread area in our Turkey and is an important species in terms of hunting tourism. Every year, inventory studies are regularly carried out in all areas where these species have distributed in Turkey. Native and foreign hunters are allowed to hunting these species by giving certain quota determined for each year and thus economic income is provided to the country. Generally, in hunting tourism, male individuals older than the age of 8 years are important. In this study, presence data matrix was prepared by determining the areas where the individuals aged 8 years and above have been located according to the counts made after hunting in Antalya region in 2016. Slope, elevation, aspect, topographic position index and ruggedness variables that are selected considering of the biology of wild goat were use for modelling. These variables were cut in local scale by using ArcGIS 10.2 software and each was prepared as a layer in ascii format. The modelling process was carried out using MaxEnt method that run via maximum entropy approach and use only presence data, and Random Forest method that run via both presence and absence data. The Roc value for MaxEnt was 0.852 and the Roc value for Random Forest method was 0.927. These results show that the models obtained by both methods are valid. The maps obtained by both models were intersected to determine the most suitable areas for wild goats. The hunting tourism map of the wild goat was obtained by using 0.6 reference value for suitable areas on the map that was acquired using intersect. And the map show that current and potential hunting areas were determined. As a result, this map is very important in terms of being a guide for hunting tourism in study area and being the first hunting tourism map of wild goats.
{"title":"Hunting Tourism Map of Wild Goat: Antalya District","authors":"H. Süel, Y. Ünal, Serkan Özdemir, A. Koca","doi":"10.30516/BILGESCI.536101","DOIUrl":"https://doi.org/10.30516/BILGESCI.536101","url":null,"abstract":"The wild goat ( Capra aegagrus ) has a very widespread area in our Turkey and is an important species in terms of hunting tourism. Every year, inventory studies are regularly carried out in all areas where these species have distributed in Turkey. Native and foreign hunters are allowed to hunting these species by giving certain quota determined for each year and thus economic income is provided to the country. Generally, in hunting tourism, male individuals older than the age of 8 years are important. In this study, presence data matrix was prepared by determining the areas where the individuals aged 8 years and above have been located according to the counts made after hunting in Antalya region in 2016. Slope, elevation, aspect, topographic position index and ruggedness variables that are selected considering of the biology of wild goat were use for modelling. These variables were cut in local scale by using ArcGIS 10.2 software and each was prepared as a layer in ascii format. The modelling process was carried out using MaxEnt method that run via maximum entropy approach and use only presence data, and Random Forest method that run via both presence and absence data. The Roc value for MaxEnt was 0.852 and the Roc value for Random Forest method was 0.927. These results show that the models obtained by both methods are valid. The maps obtained by both models were intersected to determine the most suitable areas for wild goats. The hunting tourism map of the wild goat was obtained by using 0.6 reference value for suitable areas on the map that was acquired using intersect. And the map show that current and potential hunting areas were determined. As a result, this map is very important in terms of being a guide for hunting tourism in study area and being the first hunting tourism map of wild goats.","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"397 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114376740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.30516/BILGESCI.449984
Kadir Oruçoğlu, M. Beyhan
Bu calismada Turkiye’nin Goller Bolgesi olarak adlandirilan ve DSI 18. Bolge Mudurlugu sinirlari icerisinde bulunan gollerde 2016 yili icerisinde aylik olarak alinan su orneklerinde Zn, Cr, Mn, Fe, Cu, Co, Ni, Al, As, Mo, B, Ti, V ve Ba agir metallerinin mevcudiyeti arastirilmistir. Bu agir metallerin yillik ortalama konsantrasyonlari ulkemizde yururlukte olan Su Kirliligi Kontrolu Yonetmeliginin, Kita Ici Su Kaynaklarinin Siniflarina Gore Kalite Kriterlerine ve Yerustu Su Kalitesi Yonetmeliginin, Yerustu Su Kaynaklari icin Belirli Kirleticiler ve Cevresel Kalite Standartlari’na gore degerlendirilmistir. Bu degerlendirme neticesinde arastirmanin yapildigi 15 golun agir metaller bakimindan kirlilik durumu ortaya konulmustur. Bunun yaninda kirlenme soz konusu olan gollerle ilgili cesitli oneriler sunulmustur. Calisma kapsaminda Egirdir, Kovada, Golcuk, Aksehir, Eber, Karamik, Burdur, Acigol, Salda, Yarisli, Karatas, Golhisar, Yazir, Gokgol ve Karakuyu gollerinde numune alma islemleri ve agir metal analizleri DSI 18. Bolge Mudurlugu tarafindan koordine edilmistir. Calisma sonucu yapilan degerlendirmelere gore calisma alaninda tespit edilen en yuksek agir metal birikiminin Burdur havzasi gollerinde, en dusuk birikimin de Antalya havzasi gollerinde oldugu tespit edilmistir. 15 golde yapilan 14 farkli agir metal turunun degerlendirmesinde insan kaynakli nedenlerden dolayi en fazla birikim yapan metallerin Akarcay Havzasinda yer alan Eber golunde, Cr ve As oldugu tespit edilmistir. Dogal nedenlerden dolayi gollerde en cok rastlanan metaller ise Burdur Havzasinda yer alan gollerde tespit edilen Zn, Cr, Cu, Co, Ni ve As’dir.
{"title":"Assessment of Heavy Metal Pollution in The Lakes of Lakes District - Turkey","authors":"Kadir Oruçoğlu, M. Beyhan","doi":"10.30516/BILGESCI.449984","DOIUrl":"https://doi.org/10.30516/BILGESCI.449984","url":null,"abstract":"Bu calismada Turkiye’nin Goller Bolgesi olarak adlandirilan ve DSI 18. Bolge Mudurlugu sinirlari icerisinde bulunan gollerde 2016 yili icerisinde aylik olarak alinan su orneklerinde Zn, Cr, Mn, Fe, Cu, Co, Ni, Al, As, Mo, B, Ti, V ve Ba agir metallerinin mevcudiyeti arastirilmistir. Bu agir metallerin yillik ortalama konsantrasyonlari ulkemizde yururlukte olan Su Kirliligi Kontrolu Yonetmeliginin, Kita Ici Su Kaynaklarinin Siniflarina Gore Kalite Kriterlerine ve Yerustu Su Kalitesi Yonetmeliginin, Yerustu Su Kaynaklari icin Belirli Kirleticiler ve Cevresel Kalite Standartlari’na gore degerlendirilmistir. Bu degerlendirme neticesinde arastirmanin yapildigi 15 golun agir metaller bakimindan kirlilik durumu ortaya konulmustur. Bunun yaninda kirlenme soz konusu olan gollerle ilgili cesitli oneriler sunulmustur. Calisma kapsaminda Egirdir, Kovada, Golcuk, Aksehir, Eber, Karamik, Burdur, Acigol, Salda, Yarisli, Karatas, Golhisar, Yazir, Gokgol ve Karakuyu gollerinde numune alma islemleri ve agir metal analizleri DSI 18. Bolge Mudurlugu tarafindan koordine edilmistir. Calisma sonucu yapilan degerlendirmelere gore calisma alaninda tespit edilen en yuksek agir metal birikiminin Burdur havzasi gollerinde, en dusuk birikimin de Antalya havzasi gollerinde oldugu tespit edilmistir. 15 golde yapilan 14 farkli agir metal turunun degerlendirmesinde insan kaynakli nedenlerden dolayi en fazla birikim yapan metallerin Akarcay Havzasinda yer alan Eber golunde, Cr ve As oldugu tespit edilmistir. Dogal nedenlerden dolayi gollerde en cok rastlanan metaller ise Burdur Havzasinda yer alan gollerde tespit edilen Zn, Cr, Cu, Co, Ni ve As’dir.","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114841166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.30516/BILGESCI.489785
Aydın Güllü, M. Caglar
The number of smart devices that are developed to facilitate people's everyday tasks is increasing day by day. The devices presented to the end user can communicate with each other through the concept of Industry 4.0. This process, known as the internet of things (IoT), allows devices to be controlled over the Internet. A vacuum cleaner designed in the scope of this study can connect to the internete and fulfill the assigned tasks. Autonomous home sweeping can be performed in accordance with given tasks. The autonomous electric vacuum cleaner developed in this study; body, vacuum part, sensors, battery, motors that provide movement consists of battery and electronic circuit. It can sweep itself autonomously without touching the surrounding objects by means of the absorbers on the broom which is a small design. In addition, the Bluetooth wireless communication technology that you use can be commanded via smart phone / tablet. A home plan can be defined by means of developed software. At this point, the robot can be instructed which parts to clean. In this respect, self-autonomously assigned tasks can be successfully replaced. The system also allows remote control over the internet with the help of wi-fi. Routine home sweeping is performed autonomously with the developed smart vacuum cleaner. With the developed mobile software, it is possible to choose which environment and how much the robot can work. In addition, the robot measures its own charge and can go to the charging station and the need. It has been seen that the robot fulfills the assigned tasks in a three-room home plan. With the developed Android application, the robot can be controlled automatically and manually. With the concept of internet of objects, the developing trend made it possible to produce many smart devices. When combined with economical electronics, mechanical hardware and software, a lot of innovations come into play that will make human life easier. In this developed work, it was ensured that the routine work of the people was done by means of an intelligent broom (autonomous robot). With improved hardware and software, people will save time and work power. As a result, human life will greatly facilitate.
{"title":"Bluetooth Based Smart Vacuum Design and Implementation","authors":"Aydın Güllü, M. Caglar","doi":"10.30516/BILGESCI.489785","DOIUrl":"https://doi.org/10.30516/BILGESCI.489785","url":null,"abstract":"The number of smart devices that are developed to facilitate people's everyday tasks is increasing day by day. The devices presented to the end user can communicate with each other through the concept of Industry 4.0. This process, known as the internet of things (IoT), allows devices to be controlled over the Internet. A vacuum cleaner designed in the scope of this study can connect to the internete and fulfill the assigned tasks. Autonomous home sweeping can be performed in accordance with given tasks. The autonomous electric vacuum cleaner developed in this study; body, vacuum part, sensors, battery, motors that provide movement consists of battery and electronic circuit. It can sweep itself autonomously without touching the surrounding objects by means of the absorbers on the broom which is a small design. In addition, the Bluetooth wireless communication technology that you use can be commanded via smart phone / tablet. A home plan can be defined by means of developed software. At this point, the robot can be instructed which parts to clean. In this respect, self-autonomously assigned tasks can be successfully replaced. The system also allows remote control over the internet with the help of wi-fi. Routine home sweeping is performed autonomously with the developed smart vacuum cleaner. With the developed mobile software, it is possible to choose which environment and how much the robot can work. In addition, the robot measures its own charge and can go to the charging station and the need. It has been seen that the robot fulfills the assigned tasks in a three-room home plan. With the developed Android application, the robot can be controlled automatically and manually. With the concept of internet of objects, the developing trend made it possible to produce many smart devices. When combined with economical electronics, mechanical hardware and software, a lot of innovations come into play that will make human life easier. In this developed work, it was ensured that the routine work of the people was done by means of an intelligent broom (autonomous robot). With improved hardware and software, people will save time and work power. As a result, human life will greatly facilitate.","PeriodicalId":133012,"journal":{"name":"Bilge International Journal of Science and Technology Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130138168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-30DOI: 10.30516/BILGESCI.525438
S. Tekin, Tolga Çan
Ermenek Nehri havzasi 4020 km2 ile Goksu nehrinin ana alt havzalarindan birini olusturmaktadir. Havzada heyelanlar yaygin olarak yanal ve dusey gecisli Miyosen kirintili ve karbonatli birimlerin icerisinde gozlenmektedir. 1000 m’nin uzerinde derinlige sahip vadi yamaclarinda derin kayma turu heyelanlar, resifal kirectaslarinin olusturdugu platform kenarlarindaki dik yamaclarda ise kaya dusmeleri yaygindir. Bu calismada Ermenek nehri havzasinda kayma turu heyelanlarin duyarlilik degerlendirmesi yapay sinir aglari yontemi kullanilarak gerceklestirilmistir. Calisma alaninda toplam alani 161 km2 olan 302 adet heyelan bulunmaktadir. Duyarlilik degerlendirmelerinde heyelanlari hazirlayici faktorler olarak jeoloji, sayisal yukseklik modeli, yamac egimi, puruzluluk indeksi, teget, duzlemsel, kesit yamac egrisellikleri, topografik nemlilik indeksi, ortalama egim, yuzey-roliyef orani degiskenleri kullanilmistir. Heyelan duyarlilik modellemesi icin elde edilen veri seti, rastgele secim yontemiyle %15 test, %15 dogrulama ve %70 analiz olarak uc bolume ayrilmistir. Elde edilen duyarlilik haritasi cok dusuk – cok yuksek arasinda 5 sinifta degerlendirilmistir. Duyarlilik haritasinin dogrulugu, basari tahmin ve alici isletim karakteristigi egrileriyle elde edilmistir. Duyarlilik haritasinda mevcut heyelanlarin %77’sinin, calisma alaninin %29’una karsilik gelen yuksek ve cok yuksek duyarli siniflar icerisinde yer aldigi, alici isletim egrisi altinda kalan alan ise 0.893 olarak bulunmustur. Sonuc olarak elde edilen duyarlilik haritasinin yuksek kestirim kapasitesine sahip oldugu gorulmustur.
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Pub Date : 2019-03-30DOI: 10.30516/BILGESCI.476841
Bilge Bicak, Serda Kecel Gunduz, Yagmur Kokcu, A. Ozel, S. Akyüz
The Gly-Glu (GE) dipeptide, which acts as a neurotransmitter, is made of glycine and glutamic amino acids that are used in the treatment of neurological diseases such as Schizophrenia, Parkinson and Alzheimer. Gly-Glu dipeptide is an important peptide structure that helps prevent neuronal degeneration, especially in Alzeimer's disease. Caspases which are cysteine proteases play a crucial role for apoptotic death of neurons in Alzheimer’s disease. In patients with Alzheimer's disease, there was an increase in caspase-3 immunoreactivity in the death of pyramidal neurons, where the initial sites of neuronal loss were proven (Gervais et al. 1999). The molecular structure of the GE dipeptide having anti-apoptotic properties is very important for clarifying the activation mechanism with caspase-3 protein. Molecular dynamics and molecular docking calculations were applied to elucidate the most stable molecular conformation and to grasp the mechanism of activity of GE with caspase-3. Firstly, GROMACS program was used to reveal the conformation variations of the GE within the body. The stability of the peptide is ensured by confinement in 704 water molecules. Secondly, Glide SP (standard precision) module of the Maestro 11.4 version in the Schrodinger Software program was used to determine the linkages and activity of the peptide with the caspase-3 protein. In this study, the structure of this dipeptide, pharmacological properties and its mechanism of action with caspase-3 protein were investigated for the first time by molecular dynamics and docking calculations.
Gly-Glu (GE)二肽作为一种神经递质，由甘氨酸和谷氨酸氨基酸组成，用于治疗精神分裂症、帕金森和阿尔茨海默病等神经系统疾病。Gly-Glu二肽是一种重要的肽结构，有助于防止神经元变性，特别是在阿尔茨海默病中。半胱氨酸蛋白酶Caspases在阿尔茨海默病神经元凋亡中起重要作用。在阿尔茨海默病患者中，锥体神经元死亡时caspase-3免疫反应性增加，其中神经元丢失的初始位置已被证实(Gervais et al. 1999)。具有抗凋亡特性的GE二肽的分子结构对阐明caspase-3蛋白的激活机制具有重要意义。应用分子动力学和分子对接计算，阐明最稳定的分子构象，掌握GE与caspase-3的活性机制。首先，使用GROMACS程序揭示GE在体内的构象变化。在704个水分子中保证了肽的稳定性。其次，使用Schrodinger软件中Maestro 11.4版本的Glide SP(标准精度)模块测定肽与caspase-3蛋白的连接和活性。本研究首次通过分子动力学和对接计算研究了该二肽的结构、药理性质及其与caspase-3蛋白的作用机制。
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