IEEE transactions on ultrasonics, ferroelectrics, and frequency control最新文献

Intravascular ultrasound (IVUS) is the gold standard modality for in vivo visualization of coronary arteries and atherosclerotic plaques. Classification of coronary plaques helps to characterize heterogeneous components and evaluate the risk of plaque rupture. Manual classification is time-consuming and labor-intensive. Several machine learning-based classification approaches have been proposed and evaluated in recent years. In the current study, we develop a novel pipeline composed of serial classifiers for distinguishing IVUS images into five categories: normal, calcified plaque, attenuated plaque, fibrous plaque, and echolucent plaque. The cascades comprise densely connected classification models and machine learning classifiers at different stages. Over 100,000 IVUS frames of five different lesion types were collected and labeled from 471 patients for model training and evaluation. The overall accuracy of the proposed classifier is 0.877, indicating that the proposed framework has the capacity to identify the nature and category of coronary plaques in IVUS images. Further, it may provide real-time assistance on plaque identification and facilitate clinical decision-making in routine practice.

Large abscesses are walled-off collections of pus and bacteria that often do not respond to antibiotic therapy. Standard of care involves percutaneous placement of indwelling catheter(s) for drainage, a long and uncomfortable process with high rehospitalization rates. The long-term goal of this work is to develop therapeutic ultrasound approaches to eradicate bacteria within abscesses as a noninvasive therapeutic alternative. Inertial cavitation induced by short pulses of focused ultrasound (histotripsy) is known to generate lethal mechanical damage in bacteria. Prior studies with Escherichia coli (E. coli) in suspension demonstrated that bactericidal effects increase with increasing peak negative amplitude, treatment time and duty cycle. The current study investigated correlates of bactericidal activity with histotripsy cavitation cloud size. Histotripsy was applied to E. coli suspensions in 10-mL sample vials at 810 kHz, 1.2 MHz, or 3.25 MHz for 40 minutes. The cavitation activity in the sample vials was separately observed with high-speed photography. The cavitation cloud area was quantified from those images. A linear relationship was observed between bacterial inactivation and cavitation cloud size (R² = 0.96), regardless of the acoustic parameters (specifically frequency, pulse duration and power) used to produce the cloud.

Ultrasound open scanners have recently boosted the development and validation of novel imaging techniques. They are usually split into hardware- or software-oriented systems, depending on whether they process the echo data using embedded FPGAs/DSPs or a GPU on a host PC. The goal of this work was to realize a high-performance heterogeneous open scanner capable of leveraging the strengths of both hardware and software-oriented systems. The elaboration power of the 256-channel ultrasound advanced open platform (ULA-OP 256) was further enhanced by embedding a compact co-processing GPU system-on-module (SoM). By carefully avoiding latencies and overheads through low-level optimization work, an efficient PCIe communication interface was established between the GPU and the processing devices onboard the ULA-OP 256. As a proof of concept of the enhanced system, the high frame rate color flow mapping technique was implemented on the GPU SoM and tested. Compared to a previous DSP-based implementation, higher real-time frame rates were achieved together with unprecedented flexibility in setting crucial parameters such as the ensemble length (EL). For example, by setting EL=64 and a continuous-time high-pass filter, the flow was investigated with high temporal and spatial resolution in the femoral vein bifurcation (frame rate = 1.1 kHz) and carotid artery bulb (4.3 kHz), highlighting the flow disturbances due to valve aperture and secondary velocity components, respectively. The results of this work promote the development of other computational-expensive processing algorithms in real-time and may inspire the next generation of ultrasound high-performance heterogeneous scanners.

This paper describes prototype temperature compensated piezoelectric MEMS oscillators operating in the wide temperature range of -40 °C to 85 °C for RTC applications. The AlN-on-Si resonator is centrally anchored at one point and designed for low power operation with a wide frequency tuning range of 5000 ppm. The oscillators exhibit a stable sinusoidal output at about 497 kHz frequency for time keeping applications with an integrated phase jitter being 10× better than the best commercially available MEMS RTC oscillators for supplementary use in portable devices for clocking audio circuits. The measured oscillator performance remains relatively unchanged when comparing the wafer level packaged capped MEMS resonator with the uncapped one, showing great potential for a high performance low-power RTC oscillator.

Nanodroplets are phase-changing agents that have shown great potential for ultrasound applications. When ultrasound is applied, nanodroplets can undergo a phase transition into gas bubbles, enabling cavitation that can be used to reduce the pressure threshold required for mechanical ablation of tissues. Effective tissue fractionation depends on precise vaporization to achieve uniform and predictable bubble formation. This study aimed to optimize nanodroplet vaporization using acoustic holograms for improved nanodroplet-mediated histotripsy. Tissue ablation was conducted using a two-step approach, where a rotating imaging probe was used for nanodroplet vaporization followed by low-frequency ultrasound for detonation. We developed and validated three distinct acoustic hologram patterns targeting different regions within a circular area through simulations and experiments. Using custom-made gelatin phantoms designed for optimal nanodroplet vaporization imaging, the superpositioned patterns demonstrated significantly more uniform nanodroplet vaporization compared to standard single focus steering, with nanodroplet coverage reaching 70.42 ± 6.86% for the optimized vaporization approach versus 39.32 ± 6.77% for the single focus steering. Ex vivo chicken liver experiments confirmed the enhanced efficiency of the optimized approach, resulting in significantly larger and more uniform lesion areas. Lesion areas generated by 120 seconds of treatment reached 2.19 ± 0.21 mm2 compared to 0.43 ± 0.03 mm2 for the standard approach, a 5.1-fold increase. These findings suggest that using acoustic holograms can improve nanodroplet vaporization uniformity and enhance the homogeneity of tissue fractionation, thereby potentially enhancing therapeutic outcomes.

A two port surface acoustic wave (SAW) device was developed to be used for the control and excitation via spin waves (SW). The structure was manufactured using advanced nanolithography techniques, on GaN/Si, enabling fundamental Rayleigh interdigitated transducer (IDT) resonances in GHz frequency range. The ferromagnetic resonance of the magnetostrictive Ni/NiFeSi layer placed between the IDTs of the SAW device can be tuned to the SAW resonance frequency by magnetic fields. Using structures with finger and interdigit spacing of 170 nm and 100 nm, fundamental Rayleigh IDT resonance frequencies of 6.4 and 10.4 GHz have been obtained. Coupling of SAW to SW was demonstrated through transmission measurements at the fundamental Rayleigh frequencies in a magnetic field, μ0H from -280 to +280 mT, at different angles (θ) between the SAW propagation direction and the magnetic field direction. For the 6.4 GHz resonator a maximum decrease of about 1.2 dB occurred in |S21|, at μ0H = 30 mT and at θ = 45. Time-gated processing of the frequency domain raw data was used to remove the direct electromagnetic cross talk and triple transit effects. Nonreciprocity associated to the coupling was analyzed for the two SAW structures. The quantitative influence of the magnetic field strength on the phase of the transmission parameters is also presented.

Ultrasound localization microscopy is becoming well established in preclinical applications. For its translation into clinical practice, the localization precision achievable with commercial ultrasound scanners is crucial - especially with volume imaging, which is essential for dealing with out-of-plane motion. Here, we propose an easy-to-perform method to estimate the localization precision of 3D ultrasound scanners. With this method, we evaluated imaging sequences of the Philips Epiq 7 ultrasound device using the X5-1 and the XL14-3 matrix transducers, and also tested different localization methods. For the X5-1 transducer, the best lateral, elevational, and axial precision was 109 μm, 95 μm, and 55 μm for one contrast mode, and 29 μm, 22 μm, and 19 μm for the other. The higher frequency XL14-3 transducer yielded precisions of 17 μm, 38 μm, and 6 μm using the harmonic imaging mode. Although the center of mass was the most robust localization method also often providing the best precision, the localization method has only minor influence on the localization precision compared to the impact by the imaging sequence and transducer. The results show that with one of the imaging modes of the X5-1 transducer, precisions comparable to the XL14-3 transducer can be achieved. However, due to localization precisions worse than 10 μm, reconstruction of the microvasculature at the capillary level will not be possible. These results show the importance to evaluate the localization precision of imaging sequences from different ultrasound transducers or scanners in all directions before using them for in vivo measurements.

Multimodal intravascular ultrasound and photoacoustic (IVUS/PA) imaging is a promising diagnostic tool for cardiovascular diseases like atherosclerosis. IVUS/PA catheters typically require two independent transducers due to different frequency requirements, potentially increasing the catheter size. To facilitate multimodal imaging within conventional catheter dimensions, we designed, fabricated, and characterized a dual-transducer acoustic stack where a low-frequency (LF) PA receiver sits as a matching layer for the high-frequency (HF) US transducer. While the HF transducer operates around 50 MHz, the LF receiver targets frequencies below 15 MHz to capture most of the PA energy from atherosclerotic plaque lipids. Simulation results reveal that this configuration could increase the sensitivity of the HF transducer by 3.54 dB while maintaining bandwidth. Phantom experiments with fabricated stacks showed improved performance for the US transducer, validating the enhanced sensitivity and bandwidth. Following improvements in stack fabrication, the proposed acoustic stack is a viable design that can significantly enhance diagnostic accuracy for atherosclerosis, providing high-resolution, multifrequency imaging within a compact catheter form factor.

Using acoustic vortex tweezers (AVT) to spatially accumulate microbubbles (MBs) shows promise for enhancing drug delivery efficiency and reducing off-target effects. The strong echogenicity of accumulated MBs also improves diagnostics via conventional ultrasound (US) B-mode imaging. However, the annular high-pressure distribution of AVT inhibits MBs inflow at the inlet, reducing MBs collection. The spatial resolution of US B-mode imaging further limits theranostic applications of AVT-mediated MBs accumulation. To address these challenges, we integrated an AVT waveform with volumetric super-resolution imaging (VSRI) to monitor the dynamic growth of MBs cluster during accumulation. We used a 5-MHz 2D array transducer for VSRI, employing plane wave pulses interleaved with accumulating pulses to retain MBs at a flow rate of 0.023-0.047 mL/s in a 3-mm vessel phantom. An asymmetrical AVT waveform (AVT*) was produced by modulating the pressure at the MBs inlet compared to the outlet. The effectiveness was validated in rat cerebral vessels for real-time volumetric tracking of MBs clusters. Microscopy observations showed that AVT* could quickly gather flowing MBs into cluster without repelling them at a flow rate of 0.023 mL/s. Statistical results indicated that microscopic data correlated better with VSRI than with B-mode images, suggesting VSRI suffices to detect the dynamics of AVT*-actuated MBs accumulation in real-time. Additionally, VSRI detected a significant increase in MBs cluster size over time during AVT* in the superior sagittal sinus of the rat brain. These findings demonstrate that the proposed strategy can accumulate the flowing MBs at a desired location and simultaneously observe this phenomenon.