Indo Global Journal of Pharmaceutical Sciences最新文献

{"title":"From Conventional Treatment to Targeted Antimalarial Therapy: Building Up on Innovations","authors":"S. Akash, Gupta Pritee","doi":"10.35652/igjps.2021.111003","DOIUrl":"https://doi.org/10.35652/igjps.2021.111003","url":null,"abstract":": Despite many technological advancements and innovations, infectious disease like malaria continues to be one of the greatest health challenges worldwide. The conventional drug therapy has various limitations. There are various challenges faced by drug therapy and the eradication agenda. However, various new strategies are being investigated not only to treat the parasitic disease but to prevent its spread and relapse. Nanotechnology-based approaches (diagnosis treatment and prevention), reconsidering drugs with limitations, repurposing of drugs, and development of new drugs by modifying existing compounds, re-optimizing available antimalarial, creating new combinations, etc. are some of them. The use of herbal drugs for antimalarial therapy has provided a novel approach having lesser side effects, safety, and more efficacies. Recent developments like investigating new targets for antimalarial drugs, newer and more effective mechanisms for attacking the parasite, targeting organ system and multiple stages of the parasitic life cycle and many other newer approaches may revolutionize the way we are fighting the malaria parasite soon. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82414072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study between Aqueous and Ethanolic Extracts of Allium Odorum Linn with Reference to its Antioxidant and AlphaAmylase Inhibition Activities","authors":"N. Talukdar, R. Devi, Indrani Barman","doi":"10.35652/igjps.2021.111008","DOIUrl":"https://doi.org/10.35652/igjps.2021.111008","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82480541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid Lipid Nanoparticles: A Review","authors":"M. Begum, N. B. Shaik","doi":"10.35652/igjps.2021.112004","DOIUrl":"https://doi.org/10.35652/igjps.2021.112004","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90970350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Eugenol in Clove Extract and Nanoparticle Formulation by a Validated High-Performance Thin-layer Chromatographic Method","authors":"Deepika Yadav, Shivansh Yadav, G. Jain, A. Mazumder, Roop k Khar","doi":"10.35652/igjps.2021.112006","DOIUrl":"https://doi.org/10.35652/igjps.2021.112006","url":null,"abstract":"Eugenol (4-allyl-2-methoxyphenol) is the aromatic compound of the essential oil with the potential to modulate neuronal excitability. Nose to brain route of drug delivery via nanoparticle formulation has emerged as an alternative route drug delivery system for treatment of epilepsy. A selective and sensitive analytical method is required for evaluation of eugenol-based novel drug delivery systems. The objective of present study is to develop and validate a high-performance thin-layer chromatographic (HPTLC) method for the quantitative analysis of eugenol as bulk, in clove extract and in developed eugenol-loaded nanoparticle formulation. Chromatographic separation was achieved on silica gel pre-coated TLC aluminium plates 60F254, using methanol:distilled water (6:4, v/v) as the mobile phase. Quantitative analysis was carried out by densitometry at a wavelength of 280 nm. The method was validated as per ICH guidelines, to analyse eugenol in clove extract and to evaluate eugenol-loaded nanoparticles. Eugenol spots were observed at Rf value 0.58 ± 0.02. The detector response was linear (r = 0.9991) between 0.5 and 5.0 ng/spot. The intra- and inter-day precisions were 1.08–2.17 and 1.95-3.86 %, respectively. The limit of detection was 50 ng/spot and the limit of quantification was 150 ng/spot. The method proved to be simple, accurate, reproducible and rugged for eugenol. Evaluation of eugenol-loaded nanoparticle formulation demonstrated drug loading of 35.0%, encapsulation efficiency of 47.0% and sustained drug release following biphasic pattern. The present method is useful for the quantitative and qualitative analysis of eugenol and eugenol-loaded nanoparticle formulation. It provides significant advantages in terms of greater specificity and rapid analysis. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"532 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80181769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on Nanosponges- A Versatile Drug Delivery System","authors":"G. Harsha, N. B. Shaik","doi":"10.35652/igjps.2021.111007","DOIUrl":"https://doi.org/10.35652/igjps.2021.111007","url":null,"abstract":"Target effective drug delivery systems are the novel approach for delivering various active moieties to targeted site. Targeting active moieties to a specific site is achieved by appropriate nanotechnology as targeted drug delivery system has various drawbacks. In order to combat this problem various dosage forms have been developed with nanotechnology among those the one with discrete functionalized particles are called as Nanosponges. Nanosponges are porous polymeric nanoparticles which are spherical in shape about a size of virus and can load wide variety of drugs. These nanoparticles with nanosize circulate rapidly in the body till they achieve specific target site and release drug in predictable and sustained manner. A detailed introduction about nanosponges and its various advantages when compared with vesicular systems, its mechanism of drug release, various drugs formulated as nanosponges, preparation and evaluations of nanosponges with applications in pharmacy are provided. This article provides a clear cut view of nanosponges and its targeted delivery, by which drugs with low solubility, bioavailability and adverse effects can easily formulated by overcoming all these problems. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Harsha, G.; Shaik, N.B. Review on NanospongesA Versatile Drug Delivery System. Indo Global J. Pharm. Sci., 2021; 11(1): 47-55. DOI: http://doi.org/10.35652/IGJPS.2021.111007 . Indo Global Journal of Pharmaceutical Sciences, 2021; 11(1): 47-55 48 colloidal nature and reported to have high solubilization capacity of poorly water soluble drug which provide sustained release as well as improving drug bioavailability. Because of their inner hydrophobic and outer hydrophilic branching, they are able to load both hydrophilic and hydrophobic drug molecules offering unparalleled flexibility[4]. COMPOSITION AND STRUCTURE OF","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84278532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review: p-Coumaric Acid, A Medicinally Important Phenolic Acid Moiety","authors":"S. Sharma, A. Khatkar, S. Kakkar","doi":"10.35652/igjps.2021.112007","DOIUrl":"https://doi.org/10.35652/igjps.2021.112007","url":null,"abstract":"p-Coumaric acid is an ubiquitous natural phenolic phytochemical mainly exist in two forms trans- and cis-p-coumaric acid. It occurs in free as well as in bound forms, is a common dietary polyphenol distributed in fruits, vegetables and cereals. It was considered as a powerful antioxidant and widely reported to demonstrate antimicrobial, antifungal, anticancer, antidiabetic, anti-inflammatory, antiviral, antihypertensive, antiulcer, antiprotozoal and antimelanogenic. This review contains the fundamental information about biological potential, common pathway utilized, SAR, wide source of p-coumaric acid and evidence of their role in disease prevention. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78298578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of New Analytical RP-HPLC Method for the Estimation of Antidiabetic Drugs Metformin Hydrochloride and Ertugliflozin in Combined Pharmaceutical Dosage Form","authors":"Suleman S. Khoja, Laxmanbhai J. Patel","doi":"10.35652/igjps.2021.111009","DOIUrl":"https://doi.org/10.35652/igjps.2021.111009","url":null,"abstract":"Metformin Hydrochloride and Ertugliflozin is combination of Antidiabetic drug in tablet Segluromet ® Tablet (500/7.5 mg), a member Antidiabetic drug, is a recent drug developed by Merck Sharp & Dohme Company for the treatment of Type 2 diabetes. A new sensitive and rapid HPLC method was developed for the determination of Metformin Hydrochloride and Ertugliflozin in pharmaceutical dosage forms; it was validated according to International Conference on Harmonization and Food and Drug Administration guidelines. The analysis was performed on the HPLC system equipped with a using Kromasil C18 (5 μm ), (250 mm x 4.6 mm column, with of Buffer (0.1 % v/v Phosphoric acid in water ) and Acetonitrile(ACN) in the ratio 60 : 40 v/v with at a flow rate of 1 mL/min , column temperature 25°C , total run time was 20 min, injection volume 20 μl, and detection was performed at the a wavelength (λ) of 235 nm. the calibration plot gave linear relationship over the concentration range of Metformin Hydrochloride 350, 450, 500, 550 and 600 μg/ml, and Ertugliflozin 6.80, 8.74, 9.72, 10.69 and 11.66 μg/ml, respectively. The accuracy of the proposed method was determined by recovery studies and was found to be Metformin Hydrochloride 98.5 % to 101.3 % and Ertugliflozin 98.2 % to 100.3%. The Limit of Detection were 0.0003 and 0.0009 μg/ml for Metformin Hydrochloride and Ertugliflozin, respectively and the Limit of Quantitation were 0.0037 and 0.0112 μg/ml for Metformin Hydrochloride and Ertugliflozin, respectively. % Relative Standard Deviation of the determination of precision was <2%. The results of robustness and solutions stability studies were within the acceptable limits as well the main features of the developed method are low run time and retention time of around 1.8 min for Metformin Hydrochloride (Met) and 3.8 min for Ertugliflozin (Ertu). © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Khoja, S.S.; Patel, L.J. Development and Validation of new analytical RP-HPLC method for the estimation of Antidiabetic Drugs Metformin hydrochloride and Ertugliflozin in combined pharmaceutical dosage form. Indo Global J. Pharm. Sci., 2021; 11(1): 62-69. DOI: http://doi.org/10.35652/IGJPS.2021.111009 . Indo Global Journal of Pharmaceutical Sciences, 2021; 11(1): 62-69 63 Figure. 1 Metformin Hydrochloride Ertugliflozin: Ertugliflozin is an oral, selective inhibitor of sodium glucose co-transporter-2 (SGLT2) which inhibits renal glucose reabsorption and results in urinary glucose excretion (UGE) and reductions in plasma glucose and haemoglobin A1c (Estimated Blood Sugar) in patients with type 2 diabetes mellitus (T2DM). It possesses a high selectivity for SGLT2 versus SGLT1 and other glucose transporters (GLUT1-4). Ertugliflozin is a new chemical entity with a chemical name of (1S,2S,3S,4R,5S)-5-[4-Chloro-3(4-ethoxybenzyl)phenyl]-1hydroxymethyl-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol (Figure 2). Ertugliflozin is included in the drug pr","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73897607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Approach for Producing Pharmaceuticals in Layer by Layer Fashion: Additive Manufacturing","authors":"Lakshmi Usha Ayalasomayajula, Kishore Pathivada, Radha Rani Earle, A. Bhavani","doi":"10.35652/igjps.2021.111010","DOIUrl":"https://doi.org/10.35652/igjps.2021.111010","url":null,"abstract":"drug three ABSTRACT: A novel approach for producing pharmaceuticals from digital designs, in a layer-by-layer fashion is 3D printing. It has been acclaimed as a disruptive technology having the potential to make a paradigm shift in the conventional manufacturing of pharmaceuticals products which involves various unit operations like milling, mixing, granulation, drying and compression. It results in final products of different qualities. The quality of the product is influenced by loading of the drug, release of the drug, stability of the drug and stability of pharmaceutical dosage form. FDA approved 3D printed drug is creating a novel era in pharmaceutical manufacturing. To overcome some of the challenges associated with conventional pharmaceutical unit operations, 3D printing is gaining more attention in the manufacture of pharmaceuticals in the future. 3D printing is capable of overcoming the difficulties relating to the drug delivery of peptides, potent drugs, water-soluble drugs, and the release of multi-drugs. On the other hand we can prepare patient specific or patient tailored medications on patient demand thus making safe administration of drug without any side effects or adverse drug effects. Nevertheless,certain limitations are there in terms of regulatory aspects hindering the launch of 3DP products into the market. © 2020 iGlobal Research and Publishing Foundation.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77392725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Screening for Secondary Metabolites and Nutraceutical Value of Sesbania grandiflora (L) Pers leaf extract","authors":"M. Apoorva, S. Pooja, G. Vidyasagar","doi":"10.35652/igjps.2021.111004","DOIUrl":"https://doi.org/10.35652/igjps.2021.111004","url":null,"abstract":": Sesbania grandiflora (L) Pers, commonly known as Agasthya is an Indian medicinal plant which belongs to family Fabaceae. The present study intended with various phytochemical screening, estimation of secondary metabolites and Nutraceutical value of leaf extract. The phytochemical test undertaken revealed the presence of Phenols, Flavonoids, Alkaloids, Steroids, Saponins, Glycosides and Terpenoids. Sterols content (37%) was found maximum followed by Flavonoids(18%), Cardiac Glycosides(16%), Phenols(13%), Terpenoids(11%), Tannins(4%) and Alkaloids(1%). The Nutraceutical value with respect to estimation of Primary metabolites (Carbohydrates and Proteins) and Elemental analysis was done. The total carbohydrate content was found to be maximum (162mg/100g), proteins (144mg/100g), Fructose(1.4mg/100g), and the Starch (1.08mg/100g). The Elemental analysis was carried out by AAS method, calcium found highest (12.4497ppm) and least (0.0073ppm).","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82900848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study on Media Optimization, Characterization and Purification of L-Asparaginase Producing Streptomyces sp. FSOF Strain Isolated from the Bay of Bengal Coastal Line","authors":"Tejaswini Avn, Ramesh Malothu","doi":"10.35652/igjps.2021.113005","DOIUrl":"https://doi.org/10.35652/igjps.2021.113005","url":null,"abstract":"The vast marine biodiversity provides abundant opportunities for the isolation and characterization of Streptomyces species with therapeutic applications. The present study is focused on isolation, characterization, media optimization of Streptomyces sp. FSOF strain for production and purification of L-Asparaginase at an economic level. Methods: The isolated strain from the intertidal region of Bay of Bengal coastal region is characterized by physicochemical, genotypic and by phylogenetic methods. The growth medium of Streptomyces FSOF strain is optimized for high enzyme activity and further purified by Ion exchange chromatography. Results and Conclusion: The FSOF isolate exhibited 4.3 IU/ml enzyme activity in m9 broth. The enzyme activity of the FSOF strain is further analyzed in various growth mediums where 5.9 IU/ml activity is observed in tryptic soy broth. The purified L-asparaginase from FSOF isolate exhibited 23.33 IU/mg specific activity with 3.12 fold purification. The 16s rRNA sequence of FSOF isolate is found to have 99.88% similarity with Streptomyces albidoflavius and Streptomyces odorifer strains. The sequence is further deposited in GenBank (accession number MN562193.1) for future analysis. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82536351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}