Indo Global Journal of Pharmaceutical Sciences最新文献

{"title":"Cardio-Protective Effect of Allicin in the Treatment of Hypertension: Home to Medicine","authors":"B. K. Yadav, Gopal L. Khatik","doi":"10.35652/igjps.2019.92s13","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s13","url":null,"abstract":": Allicin (Allium sativum) the most commonly used food constituents is when chopped or crushed release allin in the presence of enzymes Allinase, by losing one molecule of water and forms an active chemical constituent, Allicin. It acts as ACE inhibitor by relaxing the endothelial cells of the heart through release of nitrous oxide formation and finally decreases the peripheral resistance of heart result anti-hypertensive effect. It also reduces the oxidative stress level in hypertensive rats which also proves that it has as anti-hypertensive activity. It has various other mechanisms that reduces hypertension in humans. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite Khatik, Cardio-protective effect of allicin in the treatment of hypertension: home to medicine. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 115.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77439460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Herbal Formulations in the Treatment of Helmintheasis","authors":"Amit Sharma, S. Singh, M. Golati","doi":"10.35652/igjps.2019.92s22","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s22","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85748829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Neuropathic Pain: A Synergy of NSAIDs & Antidepressant","authors":"Shubham Kumar, Bhuban Subedi, S. Choudhury, Shubham Sharma, Indu Melkani, B. Kumar","doi":"10.35652/igjps.2019.92s01","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s01","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81076220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of Medicinally Important Weeds of Daund Tahsil from Pune District (M.S.), India","authors":"B. J.G.","doi":"10.35652/igjps.2019.9203","DOIUrl":"https://doi.org/10.35652/igjps.2019.9203","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85275068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advancements in the Treatment of Rheumatoid Arthritis- A Review","authors":"Lovepreet Kaur, Pooja Sharma, Dinesh Kumar","doi":"10.35652/igjps.2019.92s26","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s26","url":null,"abstract":"Rheumatoid arthritis (RA) is an autoimmune disorder affects the joint inflammation due to synovial proliferation and damage of the articular cartilage in the joints. According to the WHO report (2017), 1.3 million people suffer with RA worldwide. Immunosuppressants, 5-amino salicylic acids, TNF – alpha inhibitors, Interleukin -1 antagonists, and corticosteroids are treatment approaches to decrease the severity of the disease. Therapies for rheumatoid arthritis (RA) continue to increases promptly. These traditional treatment methodologies only produce symptomatic relief and are not capable to cure the disease. The purpose of this article is to discuss new treatment options, containing biosimilars, as well as novel agents inhibiting IL-6 and Janus kinase. Sarilumab is the latest biologic for the treatment of RA, approved by the U.S. Food and Drug Administration (FDA) in 2017. It is a human monoclonal antibody consuming higher affinity for the alpha subunit of the interleukin6 (IL-6) receptor. Other drugs that are presently being studied include the IL-6 cytokine blocker sarikumab, the small targeted molecule filgotinib, and many new biosimilars. New non-biologic DMARDs such as PI3Ks inhibitors Phosphoinositide 3-kinases, MMPs inhibitors, matrix metalloproteinases, Glycosidase inhibitors and cathepsin inhibitors are the other novel treatment methods used in the RA. With the discovery of new pathways and therapeutic targets, prospective novel and targeted therapeutic agents are developed that demonstrates their better efficacy in the treatment of RA. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Kaur, L.; Sharma, P.; Kumar, D. Recent Advancements in the Treatment of Rheumatoid ArthritisA Review. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 128. DOI: http://doi.org/10.35652/IGJPS.2019.92S26 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75388743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Synbiotics in Management of Lifestyle Disorders","authors":"R. Khursheed, A. Awasthi, Sheetu Wadhwa, M. Gulati, S. Singh","doi":"10.35652/igjps.2019.92s10","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s10","url":null,"abstract":"Gut microflora plays a crucial role in the metabolism of various nutritional substrates for the maintenance of human health. Numerous studies on synbiotics in both non-clinical as well as clinical cases have shown promising results in maintaining the balance of gastrointestinal (GIT) microbiota to improve health conditions. Due to certain conditions such as high fat diet, stress and sedentary lifestyle, bacterial balance may be changed leading to gut dysbiosis and thus manifests in lifestyle disorders such as diabetes, obesity and atherosclerosis. These lifestyle disorders are associated with gut dysbiosis wherein there is increase in gram negative bacteria and decrease in beneficial gram-positive bacteria. The increased level of gram negative bacteria causes increase in lipopolysacharrides (LPS), endotoxemia, diabetes, dyslipidaemia and obesity. It is seen that individuals with increased adiposity and dyslipidaemia are characterized by increased levels of LPS. Synbiotics’ administration decreases these LPS and thus decreases inflammation, insulin resistance, diabetes, adiposity and obesity. Synbiotics are also known to influence apetite as well as food intake thereby, treat obesity. Synbiotics manage dyslipidaemia by decreasing cholesterol through inhibiting its intestinal absorption, increasing its excretion and supressing the bile acid reabsorption. The current presentation highlights the role of synbiotics in management of lifestyle disorders and various marketed products containing them. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Khursheed, R.; Awasthi, A.; Wadhwa, S.; Gulati, M.; Singh, S.K. Role of synbiotics in Management of Lifestyle Disorders. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 112. DOI: http://doi.org/10.35652/IGJPS.2019.92S10 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73799106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advancements in the Treatment of Anxiety by Natural Drugs","authors":"Nikhi Sharma, Pooja Sharma, Dinesh Kumar","doi":"10.35652/igjps.2019.92s29","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s29","url":null,"abstract":": Anxiety affects about total of one-eighth individuals worldwide and has become an essential field of research in psychopharmacology. It is estimated that more than 10 million populations are suffering from anxiety every year in India. Anxiety, which is a state of extreme fear and is characterized by the sympathetic hyperactivity, vigilance syndromes, motor tension and apprehension. Several anti-anxiety drugs have been used for the treatment of anxiety. Benzodiazepens are the most important category of compounds that have been used for treating anxiety, but the long term utilization of these drugs may produce physiological and psychological dependence. Furthermore, the drugs used for anxiety can cause serious adverse effects such as sleep disturbances, cholinergic symptoms, blurred vision, weight gain, gastrointestinal problems, sexual dysfunction and medication dependence. Hence, herbal medicinal plants are used for the treatment of anxiety because of their potent therapeutic activities and lesser side effects as compare to the usual anti-anxiety drugs. Some traditional plants that are used as anxiolytics are Valeriana officinalis, Tilia europeae, Chenopodium ambrosioides and Passiflora coerulea . Valerenic acid that is obtained from Valeriana officinalis , acts with the GABA-nergic system to treat anxiety. Further, more natural drugs should be invented and researched for obtaining wide range of applications. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Sharma, N.; Sharma, P.; Kumar, D. Recent Advancements","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73337651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Capsiate in Management of Hypothermia and Life Style Diseases","authors":"A. Awasthi, R. Khursheed, M. Gulati, S. Singh","doi":"10.35652/igjps.2019.92s09","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s09","url":null,"abstract":"Capsiate is an important non-pungent phytoconstituent which is obtained from the fruits of plant Capsicum annuum. Due to non-pungency, capsiate is used in food items instead of capsaicin. The reason of capsiate non-pungency is due to its expeditious hydrolysation in the presence of aqueous conditions, which leads to decrease in its approachability towards nociceptors e.g., in the oral cavity. Capsiate consists of ester linkage between fatty acid chain and the vanillyl group while capsaicin consists of amide linkage between the vanillyl group and the fatty acid chain. On metabolism capsiate gets biotransformed and decomposed into vanillyl alchol, vanillic acid and glucuronide conjugates. Capsiate is a novel pharmacotherapeutic which helps in the management of various diseases like hypothermia, diabetes and obesity. Capsiate shows different mechanism of action in different diseases. In hypothermia capsiate act on vanilloid receptor subtype transient receptor potential cation channel subfamily V member 1 (TRPV1) and shows thermogenic effect. While in diabetes, capsiate increases the mass of beta cells which leads to increase in proliferation or decrease apoptosis of β cells and further potentiates insulin/insulin like growth factor (IGF-1) signaling. In obesity, capsiate downregulates uncoupling protein 3 (UCP-3) and enhance muscle oxidative capacity and results in decrease of abdominal fat. Through the current presentation an attempt has been made to highlight various pharmacological actions of capsiate. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Awasthi, A.; Khursheed, R.; Gulati, M.; Singh, S.K. An overview of capsiate in management of hypothermia and life style diseases. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 111. DOI: http://doi.org/10.35652/IGJPS.2019.92S09 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89550828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer’s Management","authors":"Guramritpal Singh, D. Kumar","doi":"10.35652/igjps.2019.92s55","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s55","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79011234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Software Used for New Drug Discovery and Development","authors":"G. Bawa, N. Khurana","doi":"10.35652/igjps.2019.92s03","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s03","url":null,"abstract":"Exploration of model based tools and software used for the development and discovery of new drugs in pharmaceuticals industry, playing a vital role to expand the bioactive drugs. The proper use of software and modern based computers has reduced various hindrances in the drug discovery process. The software used in pharmaceutical industry are categorized as Pharmacokinetic Parameters which include DDDPlus (Dose Dissolution and Disintegration software) to study the dissolution and disintegration of drugs, GastroPlus for the study of In vitro and in vivo correlation for various formulations; Ligand interactions and molecular dynamic such as Schodinger for the study of ligand receptor docking, GOLD (Genetic Optimization for Ligand Docking) to study the protein –ligand docking; Molecular modeling and structural activity relationship, for the study of molecular modeling analysis, prediction of protein-ligand binding affinity, create and analysis of SAR models and molecular docking and calculations and molecular modeling package Maestro, Sanjeevini, PASS() and ArgusLab are used respectively; For the study of Behavioral parameters Ethowatcher for behavioral analysis and MARS (Multimodal Animal Rotation System) to check the enzyme activity, nanoparticle tracking and delivery study followed by Data Analysis QSARPro and REST 2009 Software are used to obtain the data of protein-protein interaction and In vivo imaging display and analysis. The above mentioned softwares provide valuable insights of experimental findings and mechanisms of action. These techniques help in reduction of cost of drug designing and development. In Pharmaceutical industry softwares areexhibiting imperative role in the different phases of drug discovery. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Bawa; G.; Khurana, N. Software used for new drug discovery and development. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 105. DOI: http://doi.org/10.35652/IGJPS.2019.92S03 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72707983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}