Indo Global Journal of Pharmaceutical Sciences最新文献

{"title":"In Sighting Role of Ashwagandha: Pharmacological Review","authors":"Hardeep Singh, Pooja Sharma, Dinesh Kumar","doi":"10.35652/igjps.2019.92s43","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s43","url":null,"abstract":"Withania somnifera (Solanaceae), commonly known as Ashwagandha is an important medicinal plant that has been used in Ayurvedic medicines for more than 3,000 years. It is specially used for the treatment of nervous and sexual disorders. The chief active chemical constituents are withanolides, withaferin A, withaniferin B, withanine, somniferine, somnine, sitoindoside. Withanolides are used in the treatment of arthritis and are shown to be potent inhibition of the activation of NF-kB. Withanone protects against the cerebral damage. It also exhibits antioxidant effects by increasing the antioxidant enzymes. Sitoindosides enhance the M1 and M2 muscarinic receptor binding to alter the AChE activity. Withania somnifera also showed significance protection against stress induced gastric ulcers. Withania somnifera showed a wide range of therapeutic activities and maintaining general health such as Immunomodulation, anti-cancer and anti-epileptic, memory enhancer, to promote good physical and mental health, mood elevator, diuretic, general tonic and rejuvenator, stress reliever, anti-ageing, anti-oxidant, hypoglycemic, hypocholesterolemic. Withanolides have got analgesic and anti-inflammatory activity due to cyclooxygenase-2 inhibition property. Ashwagandha enhances nitric oxide synthase activity of the macrophages, which in turn increases the microbial killing power of these immune cells thereby enhancing the Cell Mediated Immune (CMI) response. This plant is used due to its wide range of therapeutic activities and lesser side effects as compare to synthetic drugs. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Singh, H.; Sharma, P.; Kumar, D. In Sighting Role of Ashwagandha: Pharmacological Review. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 145. DOI: http://doi.org/10.35652/IGJPS.2019.92S43 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86881132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Therapy for the Treatment of Depression","authors":"Jyoti, Pooja Sharma, Dinesh Kumar","doi":"10.35652/igjps.2019.92s36","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s36","url":null,"abstract":"Depression is a mood disorder characterized by persistently low mood and a feeling of sadness and loss of interest. In all over the world 300 million peoples are suffered with depression to the world health organization. 16.2 million adults in the united states. Although conventional antidepressant therapy can help relieve symptoms of depression and prevent relapse of the illness, complementary therapies are required due to disadvantage of the current therapy such as adverse effects. Thus, it is worthwhile to look for antidepressant from plants with proven advantage and favorable benefit to risk ratio. A number of medicinal plants and medicine derived from these plants have shown antidepressant properties by virtue of combined effect of their medicinal constituents. Most of the medicinal plants exerted antidepressant effects through synaptic regulation of serotonin, noradrenaline, dopamine and by decreasing inflammatory mediators. The medicinal plants that are used for the treatment of depression are Crocus sativus, Ginko biloba, Melissa officinalis and Valeriana officinalis. The herbal drugs should be invented further for their numerable applications and benefits. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Jyoti; Sharma, P.; Kumar, D. A Novel Therapy for the Treatment of Depression. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 138. DOI: http://doi.org/10.35652/IGJPS.2019.92S36 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76658964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Anti-Inflammatory and Analgesic Activity of Synthesized Substituted Isoxazole Derivatives","authors":"G. Kaur, Bhavneet Singh, A. Chopra, Navpreet Kaur, Divneet Kaur","doi":"10.35652/igjps.2019.92s16","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s16","url":null,"abstract":"Inflammation is the body’s response to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and initiate the healing process. Inflammations are of two types: acute and chronic. The signs of acute inflammation are warmth, redness, pain, swelling and loss of function. Chronic inflammation is characterized by long lasting pain, redness and swelling. Non steroidal anti-inflammatory drugs (NSAIDS) are used to treat pain and inflammation but is often accomplished by side effects such as gastric ulceration, bleeding, and renal function suppression. The aim of this research was to synthesize substituted isoxazole derivatives and to evaluate anti-inflammatory and analgesic activity of synthesized derivatives. In the present study, the chemicals o-hydroxyacetophenone and 1H-indole-3-carbaldehyde were reacted to synthesize 2’’-[5’-(1Hindol-3-yl)isoxazole-3’-yl]phenol. For pharmacological activity, rats were randomly divided into five groups. Group I animals served as control and received vehicle (CMC 0.5% solution) intraperitoneally. Group II (Diseased controlled vehicle group) animals were injected with 0.1ml of 1% carrageenan in planter of left hind limb. Group III (Standard control group) animals were treated with standard drug Diclofenac sodium (20mg/kg) intraperitoneally. Group IV animals were treated with test drug at a dose of 100mg/kg body weight, intraperiotneally as a suspension in CMC (0.5% solution). This study suggests that the isoxazole derivatives have significant anti-inflammatory and analgesic effect compared to standard (diclofenac). © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Kaur, G.; Singh, B.; Chopra, A.; Kaur, N.; Kaur, D. Evaluation of Anti-Inflammatory and Analgesic Activity of Synthesized Substituted Isoxazole Derivatives. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 118. DOI: http://doi.org/10.35652/IGJPS.2019.92S16 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79726399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Recent Trends in the Development of Gastro Retentive Floating Drug Delivery System","authors":"Seema Mahor, N. Prasad, P. Chandra","doi":"10.35652/igjps.2019.9103","DOIUrl":"https://doi.org/10.35652/igjps.2019.9103","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82805388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer’s Disease: Neurotransmitters Involved and the Possible New Strategies","authors":"S. Maratha, N. Falls, N. Vashist","doi":"10.35652/igjps.2019.9102","DOIUrl":"https://doi.org/10.35652/igjps.2019.9102","url":null,"abstract":"Alzheimer’s Disease (AD) is the progressive neurodegenerative disorder associated with many pathophysiological conditions. The aim of present review is to understand the learning and cognitive processes and study the various parameters related to Alzheimer’s Disease. The pathophysiological mechanism of the AD has been studied and neurotransmitters used in learning process and cognitive function have been described. The main pathophysiological symptom behind AD is β-Amyloid plaque and neurofibrillary entangles. The other reasons of AD include synaptic failure, decrease in calcium regulation, inflammatory mediators, problem in insulin signaling, depletion of neurotransmitters, oxidative stress and mitochondrial dysfunction. Cholinergic system is the major system involved in the learning and cognitive behaviour. The roles of various other neurotransmitters like angiotensin, GABA, dopamine, adrenaline, serotonin, histamine, nitric oxide and nerve growth factors have also been described. The neurotransmitters like acetylcholine, adrenaline and dopamine have been found to improve cognitive behaviour while NMDA, GABA, serotonin, histamine and angiotensin have diminishing effect on memory. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Maratha, S.K.; Falls, N.; Vashist, N.; Yadav, S.; Gahlot, V. Alzheimer’s disease: neurotransmitters involved and the possible new strategies. Indo Global J. Pharm. Sci., 2019; 9(1): 512. DOI: http://doi.org/10.35652/IGJPS.2019.9102 . Indo Global Journal of Pharmaceutical Sciences, 2019; 9(1): 5-12 6 resulting in increased brain β-amyloid [3]. The discrimination of vascular dementia from AD is dependent on evidence of a cerebrovascular disorder. There are unusual less cases of pure vascular dementia without neurodegenerative changes. The autopsy of clinically diagnosed vascular dementia emphasized on the presence of pathological signs of AD. Mild cognitive impairment has been defined as the earliest forms of dementia that may partly convert into AD [4]. NEUROMODULATORS USED IN LEARNING PROCESS AND MEMORY Various Neurotransmitters, Neuromodulators and their associated receptor systems used in learning and memory processes are given below: 1. Role of Cholinergic System The decrease in cognitive ability is mostly related to a suppression of cholinergic neurotransmission. Nicotine and nicotinic agonists have been found to upgrade cognition in animals [5]. Increased contact with nicotine results in positive changes on central cholinergic neurotransmitters and memory function [6]. Acetylcholinesterase (AChE) is an enzyme that blocks the effects of acetylcholine at the neurohumoral junctions of cholinergic nerve endings [2]. Anticholinesterase agents that are capable of crossing the blood-brain barrier have shown efficacy in the treatment of AD. Biochemical investigation of the samples obtatined from the brains of AD suffering patients shows reduction in nicotinic acetylcholine recept","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84527484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal Medicines - An Emerging Trend in the treatment of Migraine","authors":"S. Kaur, Pooja Sharma, Dinesh Kumar","doi":"10.35652/igjps.2019.92s45","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s45","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"47 24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78844777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Buccal Drug Delivery System: Novel Therapy for Diabetic Patients with Hypertension","authors":"P. Chaudhary, V. Pandit","doi":"10.35652/igjps.2019.92s27","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s27","url":null,"abstract":"The present studies aim that development of buccal drug delivery system novel therapy for diabetic patient with hypertension. Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in patients with diabetes. Lowering blood pressure is the main goal of treatment. A nonpharmacologic approach is recommended in all patients. If BP levels remains above the target despite nonpharmacologic treatment drug therapy should be initiated. Blockers of the rennin-angiotensin-aldosterone system (RAAS) represent the cornerstone of the antihypertensive drug arsenal; however, in most patients combination therapy is required. For many patients a combination of RAAS blocker and calcium antagonist is the combination preferred by treating physician. The buccal tablet was prepared by using Pioglitazone and Cilnidipine as a combined dosage form with other excipients such as cabopol 971 or 974, HPMC K4M, HPMC K15CPS, Sodium CMC, Glucodeoxycholate, β cyclodextrin, lactose, magnesium stearate, ethyl cellulose, ethanol, methanol and required amount of distilled water. The prepared buccal tablet was evaluated for physical appearance, hardness, friability, disintegration, bioadhesion strength, ex vivo residence time, swelling index and in vitro dissolution studies were performed. Stability study in natural saliva indicated that optimized formulation has good stability in human saliva. It was inferred that the prepared buccal tablet combined dosage form is very useful for the treatment of diabetic patient with hypertension. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Chaudhary, P.; Pandit, V. Development of Buccal Drug Delivery System: Novel Therapy for Diabetic Patients with Hypertension. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 129. DOI: http://doi.org/10.35652/IGJPS.2019.92S27 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"121 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84935997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aristolochia indica: A Review","authors":"M. Marwaha, Dinesh Kumar, Pooja Sharma","doi":"10.35652/igjps.2019.92s56","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s56","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72663601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Terminalia arjuna Effective in Treatment of Cardiovascular Disorder","authors":"A. Sharma, Dinesh Kumar, Pooja Sharma","doi":"10.35652/igjps.2019.92s34","DOIUrl":"https://doi.org/10.35652/igjps.2019.92s34","url":null,"abstract":"Cardiovascular diseases have become the leading cause of mortality in India. The epidemiological studies suggest that the ischaemia in cardiac muscle, stroke are the major causes and responsible for >80% of cardiovascular deaths. The Global Burden of disease study estimates of age standardized cardiovascular disease death rate of 272 per 10000 population in India is higher than its global average of 235 per 100000 population. Herbal medicine are also potent medicinal agents like synthetic drugs and are considered to be less toxic and having less side effect in contrast to synthetic drugs. The ultimate norm for any medicine is their specificity, stability, potency, non-toxicity, and efficacy. Terminalia arjuna is one of the most accepted and beneficial plant in indigenous system of medicine. Bark decoction of Terminalia Arjuna is used as a cardioprotective and cardiotonic in angina pectoris, poor blood circulation and for symptomatic relief in high blood pressure.The bark extract contains acids (arjunolic acid, terminic acid), glycosides (arjunetin, arjunosides 1,4) and strong antioxidants flavones, tannins, oligomeric proanthocyanodins. Both of the studies, experimental and clinical, have suggested that the crude drug possesses hypolipidemic, anti-atherogenic activities, anti-ischemic and antioxidant activity. © 2019 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Sharma; A.; Kumar, D.; Sharma, P. A Review of Terminalia arjuna Effective in Treatment of Cardiovascular Disorders. Indo Global J. Pharm. Sci., 2019; 9(2Suppl.): 136. DOI: http://doi.org/10.35652/IGJPS.2019.92S34 . Indo Global Journal of Pharmaceutical Sciences( ISSN 2249 1023; CODENIGJPAI; NLM ID: 101610675) indexed and abstracted in CrossRef (DOI Enabling), UGC CARE Journal List, EMBASE(Elsevier), National Library of Medicine (NLM) Catalog, ResearchGate, Publons, CAS (ACS), Index Copernicus, Google Scholar and many more. For further details, visit http://iglobaljournal.com This is a special issue as an outcome of ‘RAPSCON-2019’ sponsored by APTI and organized by Sri Sai College of Pharmacy, Manawala, Amritsar, Punjab, India. Relaxation offered in journal format.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"321 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76104633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Food Supplements Combat Cancer: An Insight","authors":"Gupta A, Vashist N, Bajaj S, Gahlot V, Y. S, Maratha S, Rajput A","doi":"10.35652/igjps.2019.9105","DOIUrl":"https://doi.org/10.35652/igjps.2019.9105","url":null,"abstract":"","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"193 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74196714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}