Indo Global Journal of Pharmaceutical Sciences最新文献

英文中文

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12032

Johra Khan

Human monkeypox disease, a rare zoonosis endemic in Western and central Africa emerged in 56 different countries around the world with an increase of 77% in cases is a global concern. Natural animal reservoir of monkeypox virus is still unknown; rodents and primates except human are the probable source of virus introduction to human. A clear and sufficient data about the virulence and transmissibility of human monkeypox disease is limited due to inconsistence in the epidemiological studies. As per World Health Organisation and Centre for Disease Control status report smallpox vaccine is found to provide 85% immunity against human monkeypox disease. There is currently no specific treatment available and two antibiotic drugs tecovirimat and brincidofovir can be used as supportive treatment for time being. ©2022iGlobal Research and PublishingFoundation. All rights reserved.

人类猴痘病是西非和中非流行的一种罕见人畜共患病，在全世界56个不同国家出现，病例增加了77%，引起全球关注。猴痘病毒的自然动物宿主尚不清楚;除人类外，啮齿动物和灵长类动物可能是人类感染病毒的来源。由于流行病学研究的不一致性，关于人类猴痘病的毒力和传播性的明确和充分的数据有限。根据世界卫生组织和疾病控制中心的状态报告，天花疫苗被发现对人类猴痘疾病提供85%的免疫力。目前尚无特异性治疗方法，可暂时使用两种抗生素药物tecovirimat和brincidofovir作为支持治疗。©2022全球研究与出版基金会。版权所有。

引用次数: 1

Preparation and Evaluation of Directly Compressible Tablets of Ibuprofen Crystals 布洛芬晶体直接可压片的制备及评价

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12019

Pooja D. Vaghela, N. Patel, H. M. Tank

The goalof present studywas to prepare the directly compressible tablets of Ibuprofen crystals prepared by crystallization technique using saccharin sodium as an excipient. The prepared tabletswere evaluatedfor the improvement in drug release of Ibuprofenas compared to the pure drug. The crystal formation of Ibuprofen lead to improve the compressibility and mechanical strength of thedrug which can be easily converted to directlycompressible tablets. The In-vitro dissolution profiledemonstrates 3.96fold incrementin the drug release rate from tablets of Ibuprofen crystals compared to the pure drug after one hour. The characterization was done byPowder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) Study of Ibuprofen treated crystals illustrates the improvement in manufacturabilityand pharmacotechnical parameters of the drug.©2022iGlobal Research and PublishingFoundation. All rights reserved.

本研究以糖精钠为辅料，采用结晶法制备布洛芬晶体直接可压缩片剂。对所制备的布洛芬片与纯药相比，在药物释放方面的改善进行了评价。布洛芬晶体的形成提高了药物的可压缩性和机械强度，易于转化为可直接压缩片剂。体外溶出谱显示，1小时后，布洛芬晶体片剂的药物释放率比纯药物增加3.96倍。通过粉末x射线衍射(pXRD)和顶空气相色谱(HSGC)对布洛芬处理后的晶体进行了表征，表明该药物的可制造性和药物技术参数得到了改善。©2022全球研究与出版基金会。版权所有。

引用次数: 0

Vaccination Strategies for Monkey Pox: An Update 猴痘疫苗接种策略:最新进展

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12031

Hitesh Chopra, Amanpreet Kaur

引用次数: 1

Formulation of Silver Nanoparticle of Cassia angustifoliaby Using Green Synthesis Method and Screening for In-Vitro Anti-Inflammatory Activity 绿色合成法制备消炎决明子纳米银颗粒及体外抗炎活性筛选

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12022

Priyanka Annaso. Patil, Shubdha Dalvi, Vishwajit D. Dhaygude, Sanmati D. Shete

The main objectives in developing nanoparticles as a delivery system are to manage particle size, surface characteristics, and the release of pharmacologically active substancesto achieve the drug's site-specific action at the appropriate rate and dose. They can help boost medication stability and have helpful controlled release features, for example.Nowadays researchers are movingtowards the green chemistry approach which is an alternative routethat is eco-friendly, cheap and fast; in that plant extracts and microorganisms are used in the reduction of the metal salt which is fast gaining demand in the field of nanobiotechnology. In this study, silver nitrate was reduced to its “nanosilver form”through a one-step synthesis protocol using an extract of Cassia Angustifolia.Three different batches namely batch A, B, C of varying temperature and another three batches namely D,E,F of varying pH were synthesized. The prepared nanoparticles were optimized and characterized by practical yield determination, drug entrapment efficiency, particle size determination and measurement of zeta potential. The synthesized nanoparticles were screened for in vitro anti-inflammatory activity.Result found that the percentage practical yield of synthesized nanoparticles waswithin the range of 6.41-52.61%. The drug entrapment efficiency was found to be 99.875%. AgNPs inhibited protein denaturation and showed 75.52% inhibition at 500μg ml-1 whereas standard drug Aspirin exhibited 65.03% protein denaturation.©2022iGlobal Research and PublishingFoundation. All rights reserved.

开发纳米颗粒作为递送系统的主要目标是管理颗粒大小，表面特性和药理活性物质的释放，以适当的速率和剂量实现药物的位点特异性作用。例如，它们可以帮助提高药物稳定性，并具有有益的控制释放功能。如今，研究人员正朝着绿色化学的方向发展，这是一种环保、廉价和快速的替代途径;其中，植物提取物和微生物被用于金属盐的还原，金属盐在纳米生物技术领域的需求迅速增加。本研究以决明子提取物为原料，通过一步合成工艺将硝酸银还原为“纳米银形态”。合成了A、B、C三个不同温度的批次和D、E、F三个不同pH的批次。对制备的纳米颗粒进行了优化，并通过实际产率测定、药物包封效率测定、粒径测定和zeta电位测定对其进行了表征。对合成的纳米颗粒进行体外抗炎活性筛选。结果表明，合成的纳米颗粒的实际产率在6.41 ~ 52.61%之间。药物包封效率为99.875%。AgNPs抑制蛋白质变性，500μg ml-1时的抑制率为75.52%，而标准药物阿司匹林的蛋白质变性率为65.03%。©2022全球研究与出版基金会。版权所有。

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引用次数: 2

Effect of Temperature and Preservation Period on the Viability of Lyophilized Bacillus subtilis 温度和保存期对枯草芽孢杆菌冻干菌活力的影响

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12017

Kim Vanessa Phoane, E. Tjoa, Shikha Joon, Listya Utami Karmawan, L. Moehario

Objective: We sought to study the effect of temperature and preservation period on the viability of lyophilized Bacillus subtilis. Methods: Forty-five test tubes that contained suspension of B. subtilisATCC 6633 were incubated for 4 hours at37°Candwashedtwicebeforefreeze-drying.Next, thelyophilizedbacteriawereexposed to different temperatures (-20°C, 2-8°C, and 25°C) and storage periods (30 days, 120 days, and 240 days). Further, the lyophilizedbacteriawere evaluated for their viability using the Milesand Misramethod.Finally, the colony count of B.subtilisineach group was compared andanalyzed using the two-way ANOVA and the Tukey-test (post-hoc test).Results: The lyophilized B. subtilisshowed the viability of 93.3% (42/45) of test tubes. All of the lyophilized B.subtilisstored at -20°C for 30, 120, and 240 days remained viable while the bacteria stored at 2-8°C and 25°Cshowed the viability of 93.3% (14/15) and 86.6%, respectively. The lyophilized B. subtilisstored at three grouptemperatures and kept for 120 and 240 days showed a significant decline in their number over thecontrolgroup(p <0.05). Conclusion: In conclusion, the temperature and preservation period significantly affect the viability of the lyophilized B. subtilis.©2022iGlobal Research and PublishingFoundation. All rights reserved.

目的:研究温度和保存时间对枯草芽孢杆菌冻干菌活力的影响。方法:45支含有枯草芽孢杆菌atcc 6633悬浮液的试管在37°条件下孵育4小时，水洗2次后冷冻干燥。接下来，将冻干的细菌暴露在不同的温度(-20°C, 2-8°C和25°C)和储存期限(30天，120天和240天)下。此外，使用Milesand misram法评估冻干细菌的生存能力。最后，采用双因素方差分析(two-way ANOVA)和事后检验(post-hoc test)对各组枯草芽孢杆菌菌落计数进行比较和分析。结果:冻干枯草芽孢杆菌的试管存活率为93.3%(42/45)。冻干枯草芽孢杆菌在-20℃条件下保存30、120和240 d，其存活率均为93.3%(14/15)，在2-8℃和25℃条件下保存的存活率为86.6%。冻干枯草芽孢杆菌在3组温度下保存120和240 d，其数量均较对照组显著减少(p <0.05)。结论:温度和保存期对枯草芽孢杆菌冻干后的活力有显著影响。©2022全球研究与出版基金会。版权所有。

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引用次数: 1

In vitro Evaluation of Physicochemical Properties of Polyherbal Anti-Wrinkle Cream 复方抗皱霜的体外理化性能评价

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12026

Usha Kiranmai G, Shayeda

Purpose: Skin ageing can be described as irregular pigmentation, increased wrinkling, loss of elasticity, dryness and roughness. Wrinkling of the skin is the most obvious sign of deterioration of the human body with age. Herbal cosmetics enhance the human appearance by playing a major role in impeding and reversing the ageing of the skin. Method: In this study, anti wrinkle creams were formulated with herbal oils of different concentrations namely AW1, AW2, AW3 and AW4. All cream formulations were evaluated for different parameters like pH, viscosity, spreadability, stability studies etc. The creams were found to be stable during stability studies done according to ICH guidelines. All in vitro tests results were analyzed statistically using SPSS software 17.0 version and compared with standard marketed formulations. Results: The formulated creams were consistent in quality and safe to be used on the skin. The Anti Wrinkle creams showed no evidence of phase separation and ease of removal. The creams were not shownany redness, edema, inflammation and irritation to the skin during skin irritation studies. The formulated creams were found statistical significant difference with that of standard at p<0.05. Conclusion: Formulations AW2 and AW4 showed good pH, viscosity, homogeneity, good spreadability, good extrudability with good appearance during the three months of stability studies. ©2022iGlobal Research and PublishingFoundation. All rights reserved.

用途:皮肤老化可以描述为不规则的色素沉着，增加皱纹，失去弹性，干燥和粗糙。皮肤起皱是人体衰老最明显的标志。草药化妆品在延缓和逆转皮肤老化方面发挥了重要作用，从而改善了人类的外表。方法:采用AW1、AW2、AW3、AW4不同浓度的草药油配制抗皱面霜。对所有乳膏配方进行了不同参数的评估，如pH值、粘度、涂抹性、稳定性研究等。在根据ICH指南进行的稳定性研究中，发现乳霜是稳定的。所有体外试验结果采用SPSS 17.0版软件进行统计分析，并与市售标准配方进行比较。结果:配制的乳膏质量一致，可安全用于皮肤。抗皱面霜没有表现出相分离和易于去除的迹象。在皮肤刺激研究中，这些面霜没有出现任何红肿、炎症和皮肤刺激。该制剂与标准制剂的差异有统计学意义(p<0.05)。结论:经过3个月的稳定性研究，AW2和AW4具有良好的pH值、粘度、均匀性、涂抹性、挤压性和美观性。©2022全球研究与出版基金会。版权所有。

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引用次数: 0

An Indigenous Study on Malassezial Susceptibility Testing by Selected Plant Extracts 植物提取物对马拉塞菌药敏试验的研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12033

he present study was carried out to evaluate the antifungal activity of tenselected plant extracts of Nelumbo nucifera,Senna auriculata, Salvia officinalis, Tagetes erecta,Psidium guajava,Argemone mexicana,Hibiscussabdariffa, Hemidesmus indicus, Moringa oleifera,andGlycyrrhizaglabrawith ketoconazole as the positive reference standard. Their antimalassezial efficacy was tested using different concentrations of extracts in various solvents. The preliminary screening of plant extracts was determined by Kirby Bauer disc diffusion method and among the tenplantextracts, aqueous extract of S.officinalisand ethanol extract of H.sabdariffaextract exhibited potent antifungal activity against Malasseziafurfur. The purification and partial characterization of H. sabdariffa and S.officinalis were carriedout by Thin layer chromatography (TLC) technique.The Minimum Inhibitory Concentration (MIC) of H.sabdariffa andS.officinalisagainst M. furfur by Kirby Bauer method was0.312mg/mLand 0.625mg/mLrespectively against 50 μg/mLof Ketoconazole which was used as the standard. The phytochemical analysis of S.officinalis and H.sabdariffa revealed the presence of terpenoids, steroids, tannins, and polyphenols of which the concentration of polyphenols and flavonoids were significantly higher in S.officinalisand H.sabdariffa respectively. Thus, the present study concludes that S.officinalisand H.sabdariffa havea potent activity against M. furfur, thereby reducing the prevalence of dandruff, provided the future perspectives of the study that includecharacterization and cytotoxicity of the compound.©2022Caproslaxy Media. All rights reserved.

以酮康唑为阳性参比标准物，对荷叶莲、木耳、鼠尾草、万寿菊、番石榴、银荷、木犀草、辣木、甘草等10种植物提取物的抑菌活性进行了研究。用不同浓度的提取物在不同溶剂中测定其抗疟菌效果。采用Kirby Bauer圆盘扩散法对10种植物提取物进行初步筛选，结果表明，金针叶水提物和金针叶乙醇提物对马拉色霉具有较强的抗真菌活性。采用薄层色谱(TLC)技术对菝葜和菝葜进行了分离纯化和部分鉴定。最小抑菌浓度(MIC)测定。以50 μg/ ml的酮康唑为对照品，Kirby - Bauer法对毛螨的药效分别为0.312mg/ ml和0.625mg/ ml。经植物化学分析，山茱萸和山茱萸均含有萜类、甾体、单宁和多酚类物质，其中多酚类物质和黄酮类物质含量显著高于山茱萸和山茱萸。因此，本研究得出结论，officinalis和H.sabdariffa对M. furfur具有有效的活性，从而减少头皮屑的流行，为未来的研究提供了前景，包括化合物的表征和细胞毒性。©2022 caproslaxy媒体。版权所有。

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引用次数: 0

Study to Assess the Efficacy of Wheatgrass Juice Therapy Intervention on Haemoglobin Level in Adolescent Anaemic Females 麦草汁治疗干预青少年贫血女性血红蛋白水平的研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12003

Deepak, Lakshmeesha D R

Background and Objectives:Wheatgrass juice is rich in various minerals like iron, magnesium, calcium, phosphorus, antioxidants like beta carotene,and insoluble dietary fibers. It has a significant amount of medicinal value with a rich source of Chlorophyll. The chemical structure of Chlorophyll is almost identical to Haemoglobin. The only difference is that magnesium is a central element in chlorophyll and iron in Haemoglobin.The vital component of wheatgrasshelps in building Haemoglobin in our body. Thus,it is used therapeutically forvarious clinical conditions involving Haemoglobin deficiency and other chronic disorders ultimately it is considered as green blood.Adolescents are susceptible to both macro and micronutrient deficiencies. Adolescent girls are mainly vulnerable groupsdue to blood loss during menstruation and poor dietary habits.The present study aims to evaluate the effect of wheatgrass fresh juice on the Haemoglobin level of adolescent anemic females. Materials and Methodology:60 subjects were selected with Haemoglobinless than 10mg/dl anddivided into two groups. Group 1-Study group wasgiven 30ml of freshly prepared wheatgrass juice on empty stomach daily for 60 days. Where Group 2-Control groupwere observed with regular activities.Results: After 60 days the symptomatic improvement and increase in Haemoglobin level in the study group was noticed as compared to the control group. Conclusion:Wheatgrass juice consumption will improve the Haemoglobin levels among anemic adolescent femalesIndex.©2022iGlobal Research and PublishingFoundation. All rights reserved.

背景和目的:小麦草汁富含各种矿物质，如铁、镁、钙、磷、抗氧化剂，如-胡萝卜素和不溶性膳食纤维。它具有丰富的叶绿素来源，具有显著的药用价值。叶绿素的化学结构与血红蛋白几乎相同。唯一的区别是，镁是叶绿素的核心元素，而铁是血红蛋白的核心元素。麦草的重要成分有助于在我们体内形成血红蛋白。因此，它被用于治疗各种临床病症，包括血红蛋白缺乏和其他慢性疾病，最终被认为是绿血。青少年易患宏量和微量营养素缺乏症。由于经期失血和不良的饮食习惯，青春期女孩是主要的弱势群体。本研究旨在评价小麦草鲜榨果汁对青少年贫血女性血红蛋白水平的影响。材料与方法:选择血红蛋白小于10mg/dl的受试者60例，分为两组。实验组1:每天空腹给予新鲜制备的小麦草汁30ml，连续60天。2组:对照组:定期活动。结果:60天后，与对照组相比，研究组症状改善，血红蛋白水平升高。结论:食用麦草汁可提高青少年贫血女性血红蛋白水平。©2022全球研究与出版基金会。版权所有。

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引用次数: 1

Design and Characterization of Sustained Release Tablet Formulation Containing Metformin Hydrochloride and Simvastatin 盐酸二甲双胍与辛伐他汀缓释片配方设计与表征

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12013

S. Dhobale, Sayali Nilakh, S. Jadhav

The aim of the present work was to develop pharmaceutical combinational dosage form for simultaneous treatment of patients with type 2 diabetes with at high-risk of coronary disease associated co-morbidities. Metformin, an antidiabetic drug is used to treat the diabetic patient and combined with Simvastatin which is HMG-CoA reductase inihibitor drug to treat the high-risk coronary disease simultaneously. In this formulation, three batches were prepared by the direct compression method. Preformulation parameters such as identification, solubility, melting point, compatibility studies, Pre-compression parameters such as bulk density, tapped density, angle of repose, Hausner ratio, compressibility index, and Post-compression parameters like weight uniformity, hardness, drug content, thickness, in-vitrodrug release. In-vitrodrug release of all formulations, B1, B2, and B3 was carried out in 0.1N HCl for 2hrs and 10 hrs in phosphate buffer (pH 6.8) dissolution media. Among all the formulations, B3 was an optimized batch. B3 formulations showed drug release of 85% for Metformin Hydrochloride and 93% for Simvastatin over a period of 12hrs.©2022iGlobal Research and PublishingFoundation. All rights reserved.

本研究的目的是开发药物组合剂型，用于同时治疗伴有冠心病相关合并症高风险的2型糖尿病患者。降糖药物二甲双胍用于治疗糖尿病患者，与HMG-CoA还原酶抑制剂辛伐他汀联合治疗高危冠心病。在该配方中，采用直接压缩法制备了三批。预处方参数，如鉴定、溶解度、熔点、相容性研究;预压缩参数，如堆积密度、抽头密度、休止角、豪斯纳比、可压缩性指数;后压缩参数，如重量均匀性、硬度、药物含量、厚度、体外药物释放。所有制剂B1、B2和B3在0.1N HCl中体外释放2h，在磷酸盐缓冲液(pH 6.8)溶出介质中体外释放10h。其中，B3为最佳配方。B3制剂在12小时内，盐酸二甲双胍的药物释放率为85%，辛伐他汀的药物释放率为93%。©2022全球研究与出版基金会。版权所有。

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引用次数: 0

A Comprehensive Review on Rising Concern of Transmission Potential of Monkeypox Virus on Healthcare System 猴痘病毒在卫生保健系统传播潜力日益受到关注的综述

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12035

R. Goyal, Mohini Devi, Rupesh K. Gautam, Sumeet Gupta

Over the past few years, thecountriesof the worldhave been afflictedwith numerousinfectious ailments. As the terrorof the COVID-19diseasewidespread decreases, nations throughoutthe worldare facing the terrorof the epidemic surrounding the pervasivenessof the geographical spread of human monkeypox cases worldwide. Thus,several approachesto decimate therisingspread of the monkeypox virus (MPXV) are warranted.MPXVcases received global attention during the 1970s, emanatingfromAfrica has fully-fledgedto be a universalconcern with MPXV cases reportedin Israel, Singapore,the United Kingdom,and the United States.Monkeypoxappears asa zoonotic viral diseasethat isinstigatedviathe monkeypox virus recognizedas the most criticalorthopoxviralinfection in humans. Transmissionof the monkeypoxvirusto human beingsis allegedto occur viadirect exposure toinfected animals or it can probablybe transmittedviaconsuminginfected meat,orblood. The transmission from humanto human takesplacethroughthe respiratory route(droplets),virus-contaminated material,and directcontact(skin-to-skin or sexual). This diseasemay be caused several difficultiesincluding,headache,fever, malaise, back pain, rash, and lymphadenopathies. Presently,there is no proven therapyfor its treatment,thusmonkeypox virus is considered a major threat to global health security. In this review, we discussed thetransmission potential of the monkeypox virus on the healthcare system, itsepidemiology, mode of transmission,and different diagnostic, preventive,and treatment approaches.©2022Caproslaxy Media. All rights reserved.

在过去的几年里，世界各国遭受了许多传染性疾病的折磨。随着对covid -19疾病广泛传播的恐惧减弱，世界各国正面临着围绕人类猴痘病例在全球范围内的地理传播的流行病的恐惧。因此，有几种方法可以抑制猴痘病毒(MPXV)的传播。MPXV病例在20世纪70年代受到全球关注，起源于非洲的MPXV病例在以色列、新加坡、英国和美国均有报道，现已成为一个普遍关注的问题。猴痘是一种由猴痘病毒引起的人畜共患病毒性疾病，被认为是人类最严重的正痘病毒感染。猴痘病毒传染给人类的途径据称是直接接触受感染的动物，也可能是通过食用受感染的肉或血液。人与人之间的传播通过呼吸道途径(飞沫)、受病毒污染的物质和直接接触(皮肤对皮肤或性接触)发生。此病可引起头痛、发热、不适、背痛、皮疹和淋巴结病等症状。目前，尚无经证实的治疗方法，因此猴痘病毒被认为是对全球卫生安全的重大威胁。在这篇综述中，我们讨论了猴痘病毒在卫生保健系统中的传播潜力、其流行病学、传播方式以及不同的诊断、预防和治疗方法。©2022 caproslaxy媒体。版权所有。

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引用次数: 1

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