Indo Global Journal of Pharmaceutical Sciences最新文献

英文中文

Phytochemical Screening for Secondary Metabolites and Nutraceutical Value of Sesbania grandiflora (L) Pers leaf extract 大田菁叶提取物次生代谢产物的植物化学筛选及营养价值研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111004

M. Apoorva, S. Pooja, G. Vidyasagar

: Sesbania grandiflora (L) Pers, commonly known as Agasthya is an Indian medicinal plant which belongs to family Fabaceae. The present study intended with various phytochemical screening, estimation of secondary metabolites and Nutraceutical value of leaf extract. The phytochemical test undertaken revealed the presence of Phenols, Flavonoids, Alkaloids, Steroids, Saponins, Glycosides and Terpenoids. Sterols content (37%) was found maximum followed by Flavonoids(18%), Cardiac Glycosides(16%), Phenols(13%), Terpenoids(11%), Tannins(4%) and Alkaloids(1%). The Nutraceutical value with respect to estimation of Primary metabolites (Carbohydrates and Proteins) and Elemental analysis was done. The total carbohydrate content was found to be maximum (162mg/100g), proteins (144mg/100g), Fructose(1.4mg/100g), and the Starch (1.08mg/100g). The Elemental analysis was carried out by AAS method, calcium found highest (12.4497ppm) and least (0.0073ppm).

大田葵(Sesbania grandflora, L)是一种印度药用植物，属于豆科。本研究旨在进行各种植物化学筛选，评估叶提取物的次生代谢产物和营养价值。植物化学试验显示，其中含有酚类、类黄酮、生物碱、类固醇、皂苷、糖苷和萜类。其中甾醇含量最高(37%)，其次为黄酮类(18%)、心苷类(16%)、酚类(13%)、萜类(11%)、单宁(4%)和生物碱(1%)。对主要代谢物(碳水化合物和蛋白质)的估算和元素分析进行了营养价值分析。其中碳水化合物(162mg/100g)、蛋白质(144mg/100g)、果糖(1.4mg/100g)和淀粉(1.08mg/100g)的总含量最高。元素分析采用原子吸收光谱法，钙含量最高(12.4497ppm)，最低(0.0073ppm)。

引用次数: 3

Biosynthesis, Characterization and Biological Studies of Copper Nanoparticles from Methanolic Extract of Bulb of Zephyranthes citrina 西风球茎甲醇提取物纳米铜的合成、表征及生物学研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112012

Prakash Jayavel, V. Subramaniam

This work reports the biosynthesis, characterization and biological studies of copper oxide nanoparticles using a methanolic extract of bulb of Zephyranthes citrina. The synthesised copper oxide nanoparticles were characterized by using various spectral techniques. The functional, structural and morphological studies were confirmed by FT-IR, XRD and SEM respectively. The elemental composition was determined by EDAX analysis. The various spectral data confirms the formation of copper oxide nanoparticles and is found to be orthorhombic, 18-50 nm of size and spherical in shape. The synthesised copper oxide nanoparticles were investigated for antibacterial activity against gram positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis), gram negative (Salmonella typhi, Escherichia coli and Klebseilla pneumoniae) and antifungal (Aspergillus niger, Candida albicans and Fusarium oxysporum) activities with different pathogens. The results revealed that copper oxide nanoparticles exhibit excellent inhibition efficiency against representative microorganisms. The outcome of the study could be useful for the development of value added products from indigenous medicinal plants. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

本文报道了利用西风球茎甲醇提取物制备氧化铜纳米颗粒的生物合成、表征和生物学研究。利用各种光谱技术对合成的氧化铜纳米粒子进行了表征。通过FT-IR、XRD和SEM对其进行了功能、结构和形态研究。元素组成用EDAX分析测定。各种光谱数据证实了氧化铜纳米颗粒的形成，并且发现它们是正交的，尺寸为18- 50nm，形状为球形。研究了合成的氧化铜纳米颗粒对革兰氏阳性(金黄色葡萄球菌、枯草芽孢杆菌和表皮葡萄球菌)、革兰氏阴性(伤寒沙门氏菌、大肠杆菌和肺炎克雷伯菌)和抗真菌(黑曲霉、白色念珠菌和尖孢镰刀菌)不同病原菌的抑菌活性。结果表明，氧化铜纳米颗粒对代表性微生物具有良好的抑制效果。研究结果可为本地药用植物的增值产品开发提供参考。©2020全球研究与出版基金会。版权所有。

{"title":"Biosynthesis, Characterization and Biological Studies of Copper Nanoparticles from Methanolic Extract of Bulb of Zephyranthes citrina","authors":"Prakash Jayavel, V. Subramaniam","doi":"10.35652/igjps.2021.112012","DOIUrl":"https://doi.org/10.35652/igjps.2021.112012","url":null,"abstract":"This work reports the biosynthesis, characterization and biological studies of copper oxide nanoparticles using a methanolic extract of bulb of Zephyranthes citrina. The synthesised copper oxide nanoparticles were characterized by using various spectral techniques. The functional, structural and morphological studies were confirmed by FT-IR, XRD and SEM respectively. The elemental composition was determined by EDAX analysis. The various spectral data confirms the formation of copper oxide nanoparticles and is found to be orthorhombic, 18-50 nm of size and spherical in shape. The synthesised copper oxide nanoparticles were investigated for antibacterial activity against gram positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis), gram negative (Salmonella typhi, Escherichia coli and Klebseilla pneumoniae) and antifungal (Aspergillus niger, Candida albicans and Fusarium oxysporum) activities with different pathogens. The results revealed that copper oxide nanoparticles exhibit excellent inhibition efficiency against representative microorganisms. The outcome of the study could be useful for the development of value added products from indigenous medicinal plants. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79139126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect of Solanum melongena Linn. Leaves Extracts on Clonidine Induced Catalepsy and Milk Induced Leukocytosis and Eosinophilia in Mice 龙葵的药效。叶提取物对可乐定致小鼠猝睡和乳致小鼠白细胞增多和嗜酸性粒细胞增多的影响

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112005

Ramdas N. Kale, Ravindra Y. Patil

Objective: To study the Effect of Solanum melongena Linn. leaves extracts on Clonidine induced catalepsy and milk induced Leukocytosis and Eosinophilia in mice. Methods: Methanolic and chloroform extracts of Solanum melongena Linn. leaves were prepared. Preliminary phytochemical screening of the prepared extracts was carried out. Effects of prepared extracts were studied on Clonidine induced catalepsy and milk induced leukocytosis and eosinophila in mice. Results: Maximum duration of catalepsy was observed at 90 min after the clonidine administration. There was significant inhibition (p˂0.05) of clonidine induced catalepsy in the animals pretreated with chlorpheniramine maleate, methanol and chloroform extract of S. melongena. Administration of milk (4mg/kg) subcutaneous route exhibited significant increase in leucocyte and eosinophil count after 24 hrs of administration. Chloroform extract at the dose of 500mg/kg body weight showed significant inhibition (p˂0.05) of milk induced leukocytosis and eosinophilia. Conclusions: These results suggest that Solanum melongena leaves extract may have the potential therapeutic value in the treatment of allergic diseases. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

目的:研究龙葵提取物的药理作用。叶提取物对可乐定致小鼠猝睡和牛奶致小鼠白细胞增多和嗜酸性粒细胞增多的影响。方法:采用龙葵的甲醇提取液和氯仿提取液。叶子准备好了。对制备的提取物进行了初步的植物化学筛选。研究了所制提取物对可乐定致小鼠猝睡和乳致小鼠白细胞和嗜酸性粒细胞的影响。结果:在给药后90min，观察到最大的麻痹持续时间。用马来酸氯苯那敏、甲醇和龙葵氯仿提取物预处理后，可显著抑制可乐定诱导的动物猝睡(p小于0.05)。皮下给药牛奶(4mg/kg) 24小时后，白细胞和嗜酸性粒细胞计数显著增加。500mg/kg体重剂量的氯仿提取物对牛奶诱导的白细胞增多和嗜酸性粒细胞增多有显著抑制作用(p小于0.05)。结论:龙葵叶提取物在过敏性疾病的治疗中具有潜在的治疗价值。©2020全球研究与出版基金会。版权所有。

{"title":"Effect of Solanum melongena Linn. Leaves Extracts on Clonidine Induced Catalepsy and Milk Induced Leukocytosis and Eosinophilia in Mice","authors":"Ramdas N. Kale, Ravindra Y. Patil","doi":"10.35652/igjps.2021.112005","DOIUrl":"https://doi.org/10.35652/igjps.2021.112005","url":null,"abstract":"Objective: To study the Effect of Solanum melongena Linn. leaves extracts on Clonidine induced catalepsy and milk induced Leukocytosis and Eosinophilia in mice. Methods: Methanolic and chloroform extracts of Solanum melongena Linn. leaves were prepared. Preliminary phytochemical screening of the prepared extracts was carried out. Effects of prepared extracts were studied on Clonidine induced catalepsy and milk induced leukocytosis and eosinophila in mice. Results: Maximum duration of catalepsy was observed at 90 min after the clonidine administration. There was significant inhibition (p˂0.05) of clonidine induced catalepsy in the animals pretreated with chlorpheniramine maleate, methanol and chloroform extract of S. melongena. Administration of milk (4mg/kg) subcutaneous route exhibited significant increase in leucocyte and eosinophil count after 24 hrs of administration. Chloroform extract at the dose of 500mg/kg body weight showed significant inhibition (p˂0.05) of milk induced leukocytosis and eosinophilia. Conclusions: These results suggest that Solanum melongena leaves extract may have the potential therapeutic value in the treatment of allergic diseases. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87443393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Treatment of AIDS: Development of Medicine by Innovation with Special Emphasis on Protease Inhibitors 艾滋病的治疗:以蛋白酶抑制剂为重点的创新医学发展

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.113004

Agnita Kundu

:In the light of the recent events in the world concerning COVID-19 virus, it is important to review the challenges faced by the world by another pandemic, AIDS. The painstaking research by the scientists, the pharmaceutical companies, the medical professionals have led to this day when AIDS patients are living their whole life span. Though we do not have any vaccine for AIDS but by intelligent use of medication, we have been able to combat the disease to a large extent. HIV is a RNA virus, whose treatment is mainly done by finding the structure and function of the proteins that are vital to its life cycle. Designing a drug/inhibitor to make those proteins ineffective constitutes the next step. WHO has recognized AIDS as a pandemic almost 40 years back but the world is yet to find a cure or a vaccine. The current treatment method is called HAART, Highly Active Anti Retroviral Therapy, where different types of inhibitors,eg. Reverse Transcriptase inhibitors, Protease inhibitors; each arresting a different important protein are given in combination. The virus replicates very fast and forms mutations which render it ineffective to the inhibitors thus resistance to the inhibitors develop. Hence development of new types of inhibitors is crucial to the problem. There are certain similarities between AIDS and COVID-19, both in terms of the attacking virus and effective medication, which make it more important than ever that the research on HIV is revisited and knowledge we gain from it is used to battle the new pandemic. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

:鉴于最近世界上发生的与COVID-19病毒有关的事件，有必要审查另一种大流行病艾滋病给世界带来的挑战。科学家，制药公司，医疗专业人员的艰苦研究，导致了今天，艾滋病患者的整个生命周期。虽然我们没有任何艾滋病疫苗，但通过明智地使用药物，我们已经能够在很大程度上与这种疾病作斗争。HIV是一种RNA病毒，其治疗主要是通过找到对其生命周期至关重要的蛋白质的结构和功能来完成的。下一步是设计一种药物/抑制剂，使这些蛋白质失效。世界卫生组织早在40年前就承认艾滋病是一种流行病，但世界尚未找到治疗方法或疫苗。目前的治疗方法被称为HAART，即高活性抗逆转录病毒疗法。逆转录酶抑制剂，蛋白酶抑制剂;每一种都捕获一种不同的重要蛋白质。病毒复制非常快，并形成突变，使其对抑制剂无效，从而对抑制剂产生耐药性。因此，开发新型抑制剂是解决这一问题的关键。在攻击病毒和有效药物方面，艾滋病和COVID-19之间存在某些相似之处，这使得重新审视艾滋病毒研究并利用我们从中获得的知识来对抗新的流行病比以往任何时候都更加重要。©2020全球研究与出版基金会。版权所有。

{"title":"Treatment of AIDS: Development of Medicine by Innovation with Special Emphasis on Protease Inhibitors","authors":"Agnita Kundu","doi":"10.35652/igjps.2021.113004","DOIUrl":"https://doi.org/10.35652/igjps.2021.113004","url":null,"abstract":":In the light of the recent events in the world concerning COVID-19 virus, it is important to review the challenges faced by the world by another pandemic, AIDS. The painstaking research by the scientists, the pharmaceutical companies, the medical professionals have led to this day when AIDS patients are living their whole life span. Though we do not have any vaccine for AIDS but by intelligent use of medication, we have been able to combat the disease to a large extent. HIV is a RNA virus, whose treatment is mainly done by finding the structure and function of the proteins that are vital to its life cycle. Designing a drug/inhibitor to make those proteins ineffective constitutes the next step. WHO has recognized AIDS as a pandemic almost 40 years back but the world is yet to find a cure or a vaccine. The current treatment method is called HAART, Highly Active Anti Retroviral Therapy, where different types of inhibitors,eg. Reverse Transcriptase inhibitors, Protease inhibitors; each arresting a different important protein are given in combination. The virus replicates very fast and forms mutations which render it ineffective to the inhibitors thus resistance to the inhibitors develop. Hence development of new types of inhibitors is crucial to the problem. There are certain similarities between AIDS and COVID-19, both in terms of the attacking virus and effective medication, which make it more important than ever that the research on HIV is revisited and knowledge we gain from it is used to battle the new pandemic. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75993162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Estimation and Comparative Analysis of Mineral Content of Syzygium jambos Fruit and Its Seed 杨梅果实及其种子矿物质含量的定量估算与比较分析

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112010

S. Dutta, K. Khaled

In recent times, medicinal plants are gaining popularity in human life as an alternative to drugs. The use of genus Syzygium, as a traditional medicine are practiced since ancient times. Syzygium jambos is one of them. It is generally found in South-East Asian countries. The fruit of this plant is commonly known as ‘Malabar plum’ / ‘Rose apple’ / ‘Plum rose’. In West Bengal (India) it is familiar as ‘Golapjam’. Purpose: The main objective of this study to the estimate mineral content like, Calcium, Phosphorus, Iron, Sodium, Potassium, Zinc, Selenium, Iodine, Copper, Manganese, Lead and Sulphur of Syzygium jambos fruit and its seed that has not been revealed yet. Method: Standard methods of AOAC have been used to quantify different mineral contents of samples. Result: The finding shows that Syzygium jambos fruit and its seed contain an adequate amount of essential macro and micro minerals. These are mostly abundant in Calcium, Phosphorus, Potassium and Copper content. Conclusion: So, it may be concluded that Syzygium jambos fruit and seed could be one of the good sources to meet the daily dietary requirements for an adult as well as it could keep diseases away. Finally, a comparative study has been done among the mineral content of Syzygium jambos fruit, seed with Jackfruit, Black plum, Watermelon and their respective edible seeds. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

近年来，药用植物作为药物的替代品在人类生活中越来越受欢迎。作为一种传统药物，紫檀属植物的使用自古以来就有实践。Syzygium jambos就是其中之一。它通常在东南亚国家发现。这种植物的果实通常被称为“马拉巴尔梅”/“玫瑰苹果”/“梅玫瑰”。在西孟加拉邦(印度)，它被称为“Golapjam”。目的:本研究的主要目的是对尚未发现的枸杞果实及其种子中钙、磷、铁、钠、钾、锌、硒、碘、铜、锰、铅、硫等矿物质的含量进行估算。方法:采用AOAC标准方法定量测定样品中不同矿物的含量。结果:枸杞果实及其种子含有适量的人体必需宏、微量矿物质。它们大多含有丰富的钙、磷、钾和铜。结论:枸杞果实和种子可作为满足成人日常饮食需求的良好来源之一，具有预防疾病的作用。最后，以菠萝蜜、黑梅、西瓜为原料，对其果实、种子及其可食种子的矿物质含量进行了比较研究。©2020全球研究与出版基金会。版权所有。

{"title":"Quantitative Estimation and Comparative Analysis of Mineral Content of Syzygium jambos Fruit and Its Seed","authors":"S. Dutta, K. Khaled","doi":"10.35652/igjps.2021.112010","DOIUrl":"https://doi.org/10.35652/igjps.2021.112010","url":null,"abstract":"In recent times, medicinal plants are gaining popularity in human life as an alternative to drugs. The use of genus Syzygium, as a traditional medicine are practiced since ancient times. Syzygium jambos is one of them. It is generally found in South-East Asian countries. The fruit of this plant is commonly known as ‘Malabar plum’ / ‘Rose apple’ / ‘Plum rose’. In West Bengal (India) it is familiar as ‘Golapjam’. Purpose: The main objective of this study to the estimate mineral content like, Calcium, Phosphorus, Iron, Sodium, Potassium, Zinc, Selenium, Iodine, Copper, Manganese, Lead and Sulphur of Syzygium jambos fruit and its seed that has not been revealed yet. Method: Standard methods of AOAC have been used to quantify different mineral contents of samples. Result: The finding shows that Syzygium jambos fruit and its seed contain an adequate amount of essential macro and micro minerals. These are mostly abundant in Calcium, Phosphorus, Potassium and Copper content. Conclusion: So, it may be concluded that Syzygium jambos fruit and seed could be one of the good sources to meet the daily dietary requirements for an adult as well as it could keep diseases away. Finally, a comparative study has been done among the mineral content of Syzygium jambos fruit, seed with Jackfruit, Black plum, Watermelon and their respective edible seeds. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79505808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

FTIR Analysis and Phytoconstituents Screening of Aegle Marmelos L. Leaves in Various Extracts 蜜瓜叶不同提取物的FTIR分析及成分筛选

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112001

T. Deokar, Sushama M. Pawar

Medicinal plants are used in traditional medicine to cure various ailments. They consist of a number of bioactive components like alkaloids, flavonoids, glycosides, steroids, tannins, phenolic compounds, etc. are used for the treatment of several diseases. Aegle marmelos L. is a spiritual, religious and important medicinal plant commonly called bael. Different parts of bael used in ethnomedicine are known to possess antioxidant, antidiarrheal, antibacterial, antidysenteric, anti-inflammatory, antipyretic, analgesic activities. The aim of the present investigation is to carry screening of phytochemical constituents and Fourier Transform Infrared spectroscopic analysis of various extracts of Aegle marmelos L. leaves. The preliminary screening of phytoconstituents was carried out by standard methods. In the Aegle marmelos L. leaves the presence of phytochemicals such as carbohydrates, proteins, amino acids, steroids, alkaloids, flavonoids, glycosides, saponins, tannins were present in aqueous, acetone, ethyl acetate, dichloromethane, ethanol, methanol and petroleum ether extract. Results of the FTIR spectra of leaves extracts revealed the presence of various functional groups like alkanes, aldehydes, amides, alcohols, esters, ethers, carboxylic acids, carbonyl group, aromatic compounds, etc. All these compounds pertain to the bioactive components and could be responsible for the medicinal properties of Aegle mermelos L. © 2020 iGlobal Research and Publishing Foundation. All

药用植物在传统医学中被用来治疗各种疾病。它们由许多生物活性成分组成，如生物碱、类黄酮、糖苷、类固醇、单宁、酚类化合物等，用于治疗几种疾病。柑橘是一种精神、宗教和重要的药用植物，通常被称为bael。在民族医学中使用的牛耳的不同部分已知具有抗氧化、止泻、抗菌、抗痢疾、抗炎、解热、镇痛的活性。本研究的目的是对蜜瓜叶的各种提取物进行植物化学成分的筛选和傅里叶变换红外光谱分析。采用标准方法对植物成分进行初步筛选。在甜瓜叶片中，水、丙酮、乙酸乙酯、二氯甲烷、乙醇、甲醇和石油醚提取物中存在碳水化合物、蛋白质、氨基酸、类固醇、生物碱、类黄酮、糖苷、皂苷、单宁等植物化学物质。叶提取物的FTIR光谱结果显示，叶提取物中含有烷烃、醛类、酰胺类、醇类、酯类、醚类、羧酸、羰基、芳香族化合物等多种官能团。所有这些化合物都属于生物活性成分，可能是鹿茸的药用特性的原因©2020 igglobal研究与出版基金会。所有

{"title":"FTIR Analysis and Phytoconstituents Screening of Aegle Marmelos L. Leaves in Various Extracts","authors":"T. Deokar, Sushama M. Pawar","doi":"10.35652/igjps.2021.112001","DOIUrl":"https://doi.org/10.35652/igjps.2021.112001","url":null,"abstract":"Medicinal plants are used in traditional medicine to cure various ailments. They consist of a number of bioactive components like alkaloids, flavonoids, glycosides, steroids, tannins, phenolic compounds, etc. are used for the treatment of several diseases. Aegle marmelos L. is a spiritual, religious and important medicinal plant commonly called bael. Different parts of bael used in ethnomedicine are known to possess antioxidant, antidiarrheal, antibacterial, antidysenteric, anti-inflammatory, antipyretic, analgesic activities. The aim of the present investigation is to carry screening of phytochemical constituents and Fourier Transform Infrared spectroscopic analysis of various extracts of Aegle marmelos L. leaves. The preliminary screening of phytoconstituents was carried out by standard methods. In the Aegle marmelos L. leaves the presence of phytochemicals such as carbohydrates, proteins, amino acids, steroids, alkaloids, flavonoids, glycosides, saponins, tannins were present in aqueous, acetone, ethyl acetate, dichloromethane, ethanol, methanol and petroleum ether extract. Results of the FTIR spectra of leaves extracts revealed the presence of various functional groups like alkanes, aldehydes, amides, alcohols, esters, ethers, carboxylic acids, carbonyl group, aromatic compounds, etc. All these compounds pertain to the bioactive components and could be responsible for the medicinal properties of Aegle mermelos L. © 2020 iGlobal Research and Publishing Foundation. All","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"85 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91522678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development and Validation of Double Divisor Ratio Spectra Derivative Method for Simultaneous Estimation of Telmisartan, Chlorthalidone and Cilnidipine in Tablet Dosage Form 双除数比光谱导数法同时测定片剂中替米沙坦、氯噻酮和西尼地平含量的建立与验证

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111001

D. Patel, Pinkal Patel, Janki Patel

: Aim: Development and Validation of Double Divisor Ratio Spectra Derivative Method for Simultaneous Estimation of Telmisartan, Chlorthalidone and Cilnidipine in Tablet Dosage Form. Method: A new method was developed for the simultaneous quantification of ternary mixtures by double divisor spectra method and validated as per International Conference on Harmonization [(ICH) Q2 (R1)] guideline. In double divisor spectra method absorption spectrum of ternary mixture divided by two of the three compounds in the mixture. Methanol used as solvent for this method. Calibration graphs were established in the range 10-50 μg/mL for Telmisartan, 7.5-17.5 μg/mL for Chlorthalidone and 5-25 μg/mL for Cilnidipine. Results: all the drugs exhibited good linearity over the reported concentration range with acceptable correlation coefficient. The method was validated according to ICH guideline parameters such as accuracy, repeatability, reproducibility showing acceptable percent relative standard deviation of less than 2. Conclusion: The proposed method demonstrated that the method is accurate, simple, precise, compounds not interference with each other and no any prior separation of compounds. © 2020 iGlobal Research and Publishing Foundation.

目的:建立双除数比光谱导数法同时测定片剂剂型中替米沙坦、氯噻酮和西尼地平的含量并进行验证。方法:根据国际协调会议[(ICH) Q2 (R1)]指南，建立了双因子谱法同时定量三元混合物的新方法。在双因子光谱法中，三元混合物的吸收光谱除以混合物中三种化合物中的两种。该方法采用甲醇作为溶剂。替米沙坦10 ~ 50 μg/mL、氯噻酮7.5 ~ 17.5 μg/mL、西尼地平5 ~ 25 μg/mL范围内建立校准图。结果:所有药物在报告的浓度范围内线性良好，相关系数可接受。根据ICH指南的准确度、重复性、再现性等参数对方法进行验证，结果显示可接受的相对标准偏差小于2。结论:该方法准确、简便、精密度高，化合物间互不干扰，不存在预先分离现象。©2020全球研究与出版基金会。

{"title":"Development and Validation of Double Divisor Ratio Spectra Derivative Method for Simultaneous Estimation of Telmisartan, Chlorthalidone and Cilnidipine in Tablet Dosage Form","authors":"D. Patel, Pinkal Patel, Janki Patel","doi":"10.35652/igjps.2021.111001","DOIUrl":"https://doi.org/10.35652/igjps.2021.111001","url":null,"abstract":": Aim: Development and Validation of Double Divisor Ratio Spectra Derivative Method for Simultaneous Estimation of Telmisartan, Chlorthalidone and Cilnidipine in Tablet Dosage Form. Method: A new method was developed for the simultaneous quantification of ternary mixtures by double divisor spectra method and validated as per International Conference on Harmonization [(ICH) Q2 (R1)] guideline. In double divisor spectra method absorption spectrum of ternary mixture divided by two of the three compounds in the mixture. Methanol used as solvent for this method. Calibration graphs were established in the range 10-50 μg/mL for Telmisartan, 7.5-17.5 μg/mL for Chlorthalidone and 5-25 μg/mL for Cilnidipine. Results: all the drugs exhibited good linearity over the reported concentration range with acceptable correlation coefficient. The method was validated according to ICH guideline parameters such as accuracy, repeatability, reproducibility showing acceptable percent relative standard deviation of less than 2. Conclusion: The proposed method demonstrated that the method is accurate, simple, precise, compounds not interference with each other and no any prior separation of compounds. © 2020 iGlobal Research and Publishing Foundation.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80365848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Antinociceptive activity shown by Aerva javanica flowering top extract and its mechanistic evaluation 土芹花顶提取物的抗伤活性及其机理评价

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111005

S. K. Swarnkar, A. Khunteta, M. Gupta, P. Jain, S. Sharma, S. Paliwal

: A grey perennial woolly tomentose shrub of Aerva javanica Burm. f. Juss. ex Schult. (Amaranthaceae), based on its folklore and traditionally usage, is needed to investigate for pharmacological potential. Therefore, as investigation of anti-nociceptive potential of the same was carried out and possible mechanism responsible for suppression of nociception was explored. Extract with hydro-alcoholic solvent (AJCE) and its ethyl acetate fraction (AJEAF) were prepared from flowering tops of A. javanica . Formalin

一种灰的多年生有毛的土芹属灌木。f。汁液。Schult交货。根据其民间传说和传统用法，需要对其药理潜力进行研究。因此，通过对其抗伤害性潜能的研究，探讨了其抑制伤害性的可能机制。以爪哇花顶为原料，采用水醇溶剂(AJCE)及其乙酸乙酯组分(AJEAF)制备了提取物。福尔马林

引用次数: 3

Development and Validation of Stability Indicating RP-HPLC Method For the Simultaneous Estimation of Glucosamine Sulphate, Methyl Sulfonyl Methane and Diacerein in Tablet Dosage Form 稳定性指示反相高效液相色谱法测定片剂剂型中硫酸氨基葡萄糖、甲磺酰基甲烷和二乙胺含量的建立与验证

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112002

G. Rajitha, A. G. Susmita, K. Kranthi

: Purpose: The objective of the proposed method is to develop an economical, accurate, precise, sensitive, reproducible, selective and validated RP-HPLC for simultaneous estimation of Glucosamine sulphate (Glu), Methyl Sulfonyl Methane (MSM) and Diacerein (Dia) in combined dosage form. Method: Mobile phase containing water and acetonitrile in the ratio of 50:50v/v was pumped through the Zodiasil C 18 150×4.6mm,3.5µ column. The flow rate was 0.8ml/min and temperature was maintained at 30°C. The eluents were observed at a wavelength of 210nm using PDA detector. Results: The retention time of Glu, MSM, and Dia were found to be 2.323, 2.842 and 3.453 respectively. The percentage RSD of intraday precision were found to be 0.5 for Glu, 0.2 for MSM and 0.7 for Dia. The percentage RSD of interday precision was found to be 0.7 for Glu, 0.8 for MSM, and 0.9 for Dia. Percentage recovery was found to be 100.30% for Glu, 99.65% for MSM and 100.13% for and Dia. Conclusion: The developed method was simple, precise, accurate, linear, rapid, economical and degradation studies revealed that the method has the ability to separate degradation products in pharmaceutical dosage forms so it can be adopted in regular quality control test for the simultaneous estimation of Glu, MSM, and Dia in tablet dosage form. © 2020 Research and Publishing Foundation. All rights

目的:建立一种经济、准确、精密度、灵敏度、重现性、选择性和可验证的反相高效液相色谱法，用于同时测定硫酸氨基葡萄糖(Glu)、甲基磺酰甲烷(MSM)和双乙酰氨基乙酯(Dia)的联合制剂。方法:将含有水和乙腈的流动相以50:50v/v的比例泵入Zodiasil C 18 150×4.6mm,3.5µ柱。流速0.8ml/min，温度维持在30℃。用PDA检测器在210nm波长下对洗脱液进行观察。结果:Glu、MSM、Dia的滞留时间分别为2.323、2.842、3.453。Glu的日内精密度RSD百分比为0.5,MSM为0.2,Dia为0.7。Glu日间精密度的RSD百分比为0.7,MSM为0.8,Dia为0.9。Glu、MSM和Dia的回收率分别为100.30%、99.65%和100.13%。结论:所建立的方法简便、精密度高、准确度高、线性、快速、经济，具有良好的降解能力，可用于片剂中Glu、MSM、Dia的同时测定。©2020研究与出版基金会。所有权利

{"title":"Development and Validation of Stability Indicating RP-HPLC Method For the Simultaneous Estimation of Glucosamine Sulphate, Methyl Sulfonyl Methane and Diacerein in Tablet Dosage Form","authors":"G. Rajitha, A. G. Susmita, K. Kranthi","doi":"10.35652/igjps.2021.112002","DOIUrl":"https://doi.org/10.35652/igjps.2021.112002","url":null,"abstract":": Purpose: The objective of the proposed method is to develop an economical, accurate, precise, sensitive, reproducible, selective and validated RP-HPLC for simultaneous estimation of Glucosamine sulphate (Glu), Methyl Sulfonyl Methane (MSM) and Diacerein (Dia) in combined dosage form. Method: Mobile phase containing water and acetonitrile in the ratio of 50:50v/v was pumped through the Zodiasil C 18 150×4.6mm,3.5µ column. The flow rate was 0.8ml/min and temperature was maintained at 30°C. The eluents were observed at a wavelength of 210nm using PDA detector. Results: The retention time of Glu, MSM, and Dia were found to be 2.323, 2.842 and 3.453 respectively. The percentage RSD of intraday precision were found to be 0.5 for Glu, 0.2 for MSM and 0.7 for Dia. The percentage RSD of interday precision was found to be 0.7 for Glu, 0.8 for MSM, and 0.9 for Dia. Percentage recovery was found to be 100.30% for Glu, 99.65% for MSM and 100.13% for and Dia. Conclusion: The developed method was simple, precise, accurate, linear, rapid, economical and degradation studies revealed that the method has the ability to separate degradation products in pharmaceutical dosage forms so it can be adopted in regular quality control test for the simultaneous estimation of Glu, MSM, and Dia in tablet dosage form. © 2020 Research and Publishing Foundation. All rights","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83417053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syntheses, Characterization and Biochemical Behaviour of Tungsten Complex 钨配合物的合成、表征及生化行为

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112009

V. K. Srivastava

The synthesis of new tungsten(V) dimeric thio complex with disulphido µ-sulphido bridge is reported Moreover, dithiocarbamate ligand is known to form stable Complex with many transition metals. The complex is of interest arises because of its versatile structure and biological activity. The tungsten complex was optimized and a description of the structural parameters is given. Finally the complex was examined as potential antimicrobial agents. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Indo Global Journal of Pharmaceutical Sciences

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀