Indo Global Journal of Pharmaceutical Sciences最新文献

英文中文

Booster Dose for Tackling Emerging Variant of SARS-CoV-2 应对新出现的SARS-CoV-2变体的加强剂

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12028

Ajay Kumar, Anupam Kumar, R. Banerjee, Nayan Das

A novel species of coronavirus has engulfed the entire world. Its severity and rate at which it transmits have left no country untouched. Massive replication has brought mutation in the genomic sequence of the virus. Due to this, many newer variants of SARS-COV-2 have come into play. Many therapies are available for covid 19, such as Remdesivir, Baricitinib, Molnupiravir, etc., but none are effective at preventing SARS-CoV-2 infection. Even most of the efficacious vaccines against the earlier variants are now inefficacious against, the newer variants. So, the people already vaccinated with the primary course of vaccination are at risk of reinfection and symptomatic COVID 19 illness.Furthermore, the initial immune response produced by these vaccines may have diminished with time, paving the pathway for discussion on the absolute need for time off and booster doses for vaccinated people. Some developed countries like the U.K and Israel favor the booster dose strategy, while some defy it, claiming it is necessary to vaccinate unvaccinated people first rather than giving vaccines multiple times. In this article, we have explained the necessity of booster doses in tackling newer variants. However, for the time being, devising a variant-specific vaccine seems promising to hiatus this transmission.©2022iGlobal Research and PublishingFoundation. All rights reserved.

一种新型冠状病毒席卷了整个世界。它的严重程度和传播速度使任何国家都无法幸免。大规模复制导致病毒基因组序列发生突变。正因为如此，许多新的SARS-COV-2变种开始发挥作用。针对covid - 19的治疗方法有很多，如Remdesivir、Baricitinib、Molnupiravir等，但没有一种能有效预防SARS-CoV-2感染。即使大多数对早期变种有效的疫苗现在对较新的变种无效。因此，已经接种过初级疫苗的人有再次感染和出现症状的COVID - 19疾病的风险。此外，这些疫苗产生的最初免疫反应可能会随着时间的推移而减弱，从而为讨论是否绝对需要休息和为接种疫苗的人增加剂量铺平了道路。英国、以色列等发达国家赞成加强接种，但也有人反对，认为有必要先给未接种疫苗的人接种疫苗，而不是多次接种疫苗。在这篇文章中，我们解释了加强剂量在处理新变种的必要性。然而，就目前而言，设计一种变异特异性疫苗似乎有望阻断这种传播。©2022全球研究与出版基金会。版权所有。

{"title":"Booster Dose for Tackling Emerging Variant of SARS-CoV-2","authors":"Ajay Kumar, Anupam Kumar, R. Banerjee, Nayan Das","doi":"10.35652/igjps.2022.12028","DOIUrl":"https://doi.org/10.35652/igjps.2022.12028","url":null,"abstract":"A novel species of coronavirus has engulfed the entire world. Its severity and rate at which it transmits have left no country untouched. Massive replication has brought mutation in the genomic sequence of the virus. Due to this, many newer variants of SARS-COV-2 have come into play. Many therapies are available for covid 19, such as Remdesivir, Baricitinib, Molnupiravir, etc., but none are effective at preventing SARS-CoV-2 infection. Even most of the efficacious vaccines against the earlier variants are now inefficacious against, the newer variants. So, the people already vaccinated with the primary course of vaccination are at risk of reinfection and symptomatic COVID 19 illness.Furthermore, the initial immune response produced by these vaccines may have diminished with time, paving the pathway for discussion on the absolute need for time off and booster doses for vaccinated people. Some developed countries like the U.K and Israel favor the booster dose strategy, while some defy it, claiming it is necessary to vaccinate unvaccinated people first rather than giving vaccines multiple times. In this article, we have explained the necessity of booster doses in tackling newer variants. However, for the time being, devising a variant-specific vaccine seems promising to hiatus this transmission.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91230790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Translation of Gold Nanoparticles into Effective Neuromedicines: Bottlenecks & Future Prospects 金纳米颗粒转化为有效神经药物的临床研究:瓶颈与未来展望

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12005

N T Pramathesh Mishra, Shalini Yadav, Mayank Khantwal, Wasim Khan, Salman Khan

Nanotechnology is the most interesting and advance area of research field in the current date. Nanoparticles are defined as a substance whose particle size varies between 1-100nm.This review focus on the potential of gold nanoparticlesto be used as an alternative to available neuromedicines due to their various unique properties. This paper also deals with advantages of gold nanoparticlesover available neuromedicines along with various bottlenecks in the translation of gold nanoparticles into effective neuromedicinesand the future perspective or scope of gold nanoparticles to be used as neuromedicines.©2022iGlobal Research and PublishingFoundation. All rights reserved.

引用次数: 2

Emulgel –Emerging as a Smarter Value-Added Product Line Extension for Topical Preparation 乳液-作为外用制剂的智能增值产品线的延伸

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12008

Neelam Patel, S. Chaudhary, Ankit Chaudhary

Topical products applied to skin in consistency from liquids to powder in formulation but the most popular product issemisolid preparation. In semisolid preparation comparison with others, the use of gels has been emerged for both in dermatologyand cosmetology. Despite of many advantages of gels one limitation for in delivery of hydrophobic drug moiety.Emulgel technique contains both oil and aqueous gel base so it can be used for hydrophobic drugs.Emulgel technique also useful for product line extension for drug available in ointment and cream formulation. Emulgel can also provide local concentration of drug in affected area so it is more effective than regular gel in curative aspects and more depth permeation of drug.Emulgelare thermodynamically stable systems having severalfeatures like enhanced permeability;prolong drug release,stability of emulsion and good thermodynamic stability. Fromthis review,we get the knowledge about emulgel formulation, advantages, characterizationand recent advances in the research field.©2022iGlobal Research and PublishingFoundation. All rights reserved.

局部产品应用于皮肤的稠度从液体到粉末的配方，但最受欢迎的产品是半固体制剂。与其他半固体制剂相比，凝胶的使用已经出现在皮肤病学和美容学中。尽管凝胶有许多优点，但在递送疏水药物部分方面有一个限制。乳凝胶技术含有油和水凝胶基，因此可用于疏水药物。乳凝胶技术也有助于产品线的延伸，药物可在软膏和乳膏配方。乳凝胶还能在患处提供局部药物浓度，因此在治疗方面比普通凝胶更有效，药物渗透更深入。乳剂是一种热力学稳定的体系，具有增强渗透性、延长药物释放时间、乳剂稳定性和良好的热力学稳定性等特点。本文综述了乳凝胶的配方、优点、表征及研究进展。©2022全球研究与出版基金会。版权所有。

引用次数: 2

Biased Studies and Sampling from LGBTQ Communities Created a Next-Level Social Stigma in Monkeypox: A Public Health Emergency of International Concern (PHEIC) 来自LGBTQ社区的有偏见的研究和抽样造成了猴痘的下一级社会耻辱:国际关注的突发公共卫生事件(PHEIC)

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12025

Rajeev K. Singla, Shailja Singla, Bairong Shen

Since 2020, we are witnessing a COVID-19 pandemic that has ruled out all other pandemics ever happened in our history. Countries are still not be able to manage the COVID-19 threat properly, and while we are still dealing with it, here comes another deadlyinfectious disease, monkeypox. Rapid circulation of monkeypox infections worldwide has forced the WHO to declared it as PHEIC. As per the current reports available on WHO, though the monkeypox is alarmingly spreading, but this threat seems to be quite manageable if dealt properly with smallpox vaccine and other antibiotic regimens in proper place. Key challenge now is actually how to control misinformation and misleading news that flooded the social media and news outlets. We have gathered studies available on the PubMed search engine since the starting of 2022, and also collected relevant information from WHO and other reliable news sources. As on 27.07.2022, WHO reported 19,178 laboratory confirmed cases, and out of these, on the white paper, only for 31.8% cases, there was recorded information about the sexual orientation. But if we look at the scientific publications and social media, it is only men having sex with men (MSM) who are the main victims and having monkeypox infections. Same message is being circulated to the common public through such channels. It is thus becoming responsibility of WHO, government and public health agencies to properly guide the public and aware them about the misleading information. Further, the presence of monkeypox DNA in the urine and feces have again showcased the role of wastewater management and proper surveillance.©2022iGlobal Research and PublishingFoundation. All rights reserved.

自2020年以来，我们正在目睹COVID-19大流行，这已经排除了我们历史上发生过的所有其他大流行。各国仍然无法妥善应对COVID-19的威胁，而在我们仍在应对这一威胁的同时，又出现了另一种致命的传染病——猴痘。猴痘感染在世界范围内的快速传播迫使世卫组织宣布其为国际关注的突发公共卫生事件。根据世卫组织目前可获得的报告，虽然猴痘正在惊人地蔓延，但如果妥善处理天花疫苗和其他抗生素方案，这一威胁似乎是相当可控的。现在的关键挑战实际上是如何控制充斥社交媒体和新闻机构的错误信息和误导性新闻。我们收集了自2022年初以来PubMed搜索引擎上的研究结果，并从世界卫生组织和其他可靠的新闻来源收集了相关信息。截至2022年7月27日，世卫组织报告了19178例实验室确诊病例，其中，在白皮书中，只有31.8%的病例记录了性取向信息。但如果我们看一下科学出版物和社交媒体，只有男男性行为者(MSM)才是猴痘感染的主要受害者。同样的信息也正在通过这些渠道向公众散发。因此，世卫组织、各国政府和公共卫生机构有责任适当地指导公众并使他们了解误导性信息。此外，尿液和粪便中存在猴痘DNA再次显示了废水管理和适当监测的作用。©2022全球研究与出版基金会。版权所有。

{"title":"Biased Studies and Sampling from LGBTQ Communities Created a Next-Level Social Stigma in Monkeypox: A Public Health Emergency of International Concern (PHEIC)","authors":"Rajeev K. Singla, Shailja Singla, Bairong Shen","doi":"10.35652/igjps.2022.12025","DOIUrl":"https://doi.org/10.35652/igjps.2022.12025","url":null,"abstract":"Since 2020, we are witnessing a COVID-19 pandemic that has ruled out all other pandemics ever happened in our history. Countries are still not be able to manage the COVID-19 threat properly, and while we are still dealing with it, here comes another deadlyinfectious disease, monkeypox. Rapid circulation of monkeypox infections worldwide has forced the WHO to declared it as PHEIC. As per the current reports available on WHO, though the monkeypox is alarmingly spreading, but this threat seems to be quite manageable if dealt properly with smallpox vaccine and other antibiotic regimens in proper place. Key challenge now is actually how to control misinformation and misleading news that flooded the social media and news outlets. We have gathered studies available on the PubMed search engine since the starting of 2022, and also collected relevant information from WHO and other reliable news sources. As on 27.07.2022, WHO reported 19,178 laboratory confirmed cases, and out of these, on the white paper, only for 31.8% cases, there was recorded information about the sexual orientation. But if we look at the scientific publications and social media, it is only men having sex with men (MSM) who are the main victims and having monkeypox infections. Same message is being circulated to the common public through such channels. It is thus becoming responsibility of WHO, government and public health agencies to properly guide the public and aware them about the misleading information. Further, the presence of monkeypox DNA in the urine and feces have again showcased the role of wastewater management and proper surveillance.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82932366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In vitroAxillary Mass Multiplication of Trichodesma indicum 籼稻赤霉病的体外腋窝大量增殖

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12015

Shameema Yousuf, Santosh Kumar Singh

In vitro mass propagation has been regarded as a significant technique formass propagation of plantlets in a short period and utilization of cell suspension cultures for metabolite generation. It has helped in biodiversity conservation of many endemic plants since it provides a way for the utilization of plant germplasm withoutdestroying natural habitats. Trichodesma indicumis one of the most significant medicinal herbs and desired for many formulations in the medical sector. Its overexploitation from natural habitats may be a threat to its diversity. The authors have proposedan optimized protocol for plantlet generation with greater viability potential and could be used to mass propagate plants in a short period. It was evident from the study that variable combinations of plant growth regulators and sucrose were able to alterthe multiplication potential of axillary buds and it could be enhanced with the proper combination.©2022iGlobal Research and PublishingFoundation. All rights reserved.

试管苗短时间内大量繁殖和利用细胞悬浮培养产生代谢物是试管苗快速繁殖的重要技术之一。它为在不破坏自然生境的情况下利用植物种质资源提供了一条途径，有助于保护许多特有植物的生物多样性。indicumtrichodesma是最重要的草药之一，在医疗部门的许多配方中都需要它。对其自然栖息地的过度开发可能对其多样性构成威胁。作者提出了一种具有较大生存潜力的优化植株生成方案，可在短时间内实现植株的大批量繁殖。研究结果表明，植物生长调节剂与蔗糖的可变组合能够改变腋芽的增殖势，并且通过适当的组合可以增强腋芽的增殖势。©2022全球研究与出版基金会。版权所有。

引用次数: 0

Nutraceuticals in the Work of Scribonius Largus, a Pioneer of Clinical Pharmacy in Ancient Rome 古罗马临床药学先驱斯克里博尼乌斯·拉格斯著作中的营养药品

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12021

C. Tsagkaris, L. Matiashova, Andreas S. Papazoglou, Dimitrios V. Moysidis, A. Loudovikou, A. Alexiou, S. Papadakos

The therapeutic potential of nutraceuticals has been recognized by severalancient civilizations. The majority of physicians would use them in their practice and transmit their experience to their disciples. Nonetheless, few physicians have contributed to the dissemination of this knowledge further and its integration intothe standard of care of their era. Scribonius Largus, a renowned physician and pharmacist in ancient Rome has summarized the existing knowledge on nutraceuticals in his pharmacognosy and therapeutics textbook “Compositiones”. As a physician to the imperial court, he used his position and resources to advance the relevant knowledge, educate erudite and lay physicians across the Roman Empire,and establish ethical practices in the field. Revisiting his contributions provides valuable lessons for contemporary researchers and practitioners.©2022iGlobal Research and PublishingFoundation. All rights reserved.

营养保健品的治疗潜力已被几个古代文明所认识。大多数医生会在他们的实践中使用它们，并将他们的经验传授给他们的弟子。尽管如此，很少有医生为进一步传播这一知识并将其融入他们那个时代的护理标准做出了贡献。古罗马著名的医生和药剂师斯克里博尼乌斯·拉格斯在他的生药学和治疗学教科书《复方》中总结了现有的营养保健品知识。作为一名宫廷医生，他利用自己的地位和资源推动相关知识的发展，在整个罗马帝国培养博学和非专业的医生，并在该领域建立道德规范。回顾他的贡献为当代研究者和实践者提供了宝贵的经验。©2022全球研究与出版基金会。版权所有。

引用次数: 0

A Brief Overview on the Health Benefits of Nyctanthes arbor-tristisLinn.-A Wonder of Mother Nature 菊科植物三叶草的保健作用综述。-大自然的奇迹

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12024

Ria Chakraborty, Santa Datta(De)

Ayurveda is one of the oldest systems of drugs. It principally uses plants and their extracts for treatment and management of assorted diseases. Nyctanthes arbor-tristisLinn.(NAT) is documented Indian ancient plant that has high medicative worth in Ayurveda. It’s popularly called Parijat or Harsingar principally found in southern elements of Asian nation & Nepal etc. Phytochemicals like flavanol organic compound, oleanic acid, essential oils, phenol, carotene, friedeline, lupeol, glucose, benzoic acid have been reported for vital hepatoprotective, anti-allergy, antianxiety, anti-filarial, antianemia, antidiabetic, antimalarial, antibacterial, anti-inflammatory, anticancer activities. Each a district of the plant has some specifichealthful price and is so commercially exploitable. Thus,it’s thought of as a valuable supply of some distinctive medicative, merchandise formation against numerous diseases. The descriptions of scientific classification, family and genus characters, vernacular names, habitat, morphology, ancient medicine, therapeutic use etc. are richly mentioned throughout this criticism. ©2022iGlobal Research and PublishingFoundation. All rights reserved.

阿育吠陀是最古老的药物体系之一。它主要利用植物及其提取物来治疗和管理各种疾病。夜来香是一种有文献记载的印度古代植物，在阿育吠陀医学中具有很高的药用价值。它通常被称为Parijat或Harsingar，主要分布在亚洲国家和尼泊尔等的南部地区。植物化学物质如黄烷醇有机化合物、齐ole果酸、精油、苯酚、胡萝卜素、弗里德林、luppeol、葡萄糖、苯甲酸等已被报道具有重要的保肝、抗过敏、抗焦虑、抗丝虫病、抗贫血、抗糖尿病、抗疟疾、抗菌、抗炎、抗癌活性。植物的每个区域都有特定的健康价格，因此具有商业开发价值。因此，它被认为是一种有价值的供应，一些独特的药物，商品形成对抗许多疾病。对科学分类、科属特征、白话名称、生境、形态、古代医学、治疗用途等方面的描述在整篇批评文章中都有大量提及。©2022全球研究与出版基金会。版权所有。

{"title":"A Brief Overview on the Health Benefits of Nyctanthes arbor-tristisLinn.-A Wonder of Mother Nature","authors":"Ria Chakraborty, Santa Datta(De)","doi":"10.35652/igjps.2022.12024","DOIUrl":"https://doi.org/10.35652/igjps.2022.12024","url":null,"abstract":"Ayurveda is one of the oldest systems of drugs. It principally uses plants and their extracts for treatment and management of assorted diseases. Nyctanthes arbor-tristisLinn.(NAT) is documented Indian ancient plant that has high medicative worth in Ayurveda. It’s popularly called Parijat or Harsingar principally found in southern elements of Asian nation & Nepal etc. Phytochemicals like flavanol organic compound, oleanic acid, essential oils, phenol, carotene, friedeline, lupeol, glucose, benzoic acid have been reported for vital hepatoprotective, anti-allergy, antianxiety, anti-filarial, antianemia, antidiabetic, antimalarial, antibacterial, anti-inflammatory, anticancer activities. Each a district of the plant has some specifichealthful price and is so commercially exploitable. Thus,it’s thought of as a valuable supply of some distinctive medicative, merchandise formation against numerous diseases. The descriptions of scientific classification, family and genus characters, vernacular names, habitat, morphology, ancient medicine, therapeutic use etc. are richly mentioned throughout this criticism. ©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78838192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Microsponge as Novel Drug Delivery System: A Review 微海绵作为新型给药系统的研究进展

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12002

Pratima Jayasawal, N. G. R. Rao, V. Jakhmola

During the last few decades, pharmaceutical industry gave more importance to the controlled release of dosage forms like solid formulation, semi solid formulation, and topicalpreparation dueto efficacy and patient compliance. Normal topical preparations have some disadvantages like unpleasant odour, greasiness, and skin irritation reported in study cases. Also many topicalpreparations fail to reach the systemic circulation in sufficient amounts in few cases. This problem is achieved by the present formulation as microsponge in the areas of research. MDS is amicroscopic sphere capable of absorbing skin secretions, therefore reducing the oiliness of the skin. Microspongehaving particle size of 10-25 microns in diameter, have wide range of entrapmentof various ingredients in a single microsponges system and release them at desired rates.Microsponge is recent novel technique for control release and targetspecific drug delivery system. Microsponges are polymeric delivery system composed of porous microspheres. They are tiny sponge-like sphericalparticle with a large porous surface.Drug release in microsponge is done by the external stimuli like (pH, temperature, rubbing). It hasseveral advantageous over the other topical preparations are non allergenic, non toxic, non irritant, non mutagenic. Microsponges are designed to deliver apharmaceutical active ingredient efficiently at the minimum dose and alsoto enhance stability, reduce side effects and modify drug release.©2022iGlobal Research and PublishingFoundation. All rights reserved.

在过去的几十年里，由于疗效和患者依从性，制药工业更加重视固体制剂、半固体制剂和局部制剂等剂型的控释。正常的局部制剂有一些缺点，如难闻的气味，油腻，和皮肤刺激报道的研究案例。此外，在少数情况下，许多局部制剂不能以足够的量到达体循环。这一问题目前是通过微海绵的配方来实现的。MDS是一种能够吸收皮肤分泌物的微观球体，因此可以减少皮肤的油性。微海绵的粒径为10-25微米，在单个微海绵系统中可以广泛地捕获各种成分，并以所需的速率释放它们。微海绵是近年来发展起来的一种新型药物控释和靶向给药系统。微海绵是由多孔微球组成的高分子输送系统。它们是微小的海绵状球形颗粒，表面有很大的多孔性。微海绵中的药物释放是通过外部刺激(pH值、温度、摩擦)来完成的。与其他外用制剂相比，它具有非过敏性、无毒、无刺激性、非致突变性等优点。微海绵旨在以最小剂量有效地递送药物活性成分，并提高稳定性，减少副作用和改变药物释放。©2022全球研究与出版基金会。版权所有。

{"title":"Microsponge as Novel Drug Delivery System: A Review","authors":"Pratima Jayasawal, N. G. R. Rao, V. Jakhmola","doi":"10.35652/igjps.2022.12002","DOIUrl":"https://doi.org/10.35652/igjps.2022.12002","url":null,"abstract":"During the last few decades, pharmaceutical industry gave more importance to the controlled release of dosage forms like solid formulation, semi solid formulation, and topicalpreparation dueto efficacy and patient compliance. Normal topical preparations have some disadvantages like unpleasant odour, greasiness, and skin irritation reported in study cases. Also many topicalpreparations fail to reach the systemic circulation in sufficient amounts in few cases. This problem is achieved by the present formulation as microsponge in the areas of research. MDS is amicroscopic sphere capable of absorbing skin secretions, therefore reducing the oiliness of the skin. Microspongehaving particle size of 10-25 microns in diameter, have wide range of entrapmentof various ingredients in a single microsponges system and release them at desired rates.Microsponge is recent novel technique for control release and targetspecific drug delivery system. Microsponges are polymeric delivery system composed of porous microspheres. They are tiny sponge-like sphericalparticle with a large porous surface.Drug release in microsponge is done by the external stimuli like (pH, temperature, rubbing). It hasseveral advantageous over the other topical preparations are non allergenic, non toxic, non irritant, non mutagenic. Microsponges are designed to deliver apharmaceutical active ingredient efficiently at the minimum dose and alsoto enhance stability, reduce side effects and modify drug release.©2022iGlobal Research and PublishingFoundation. All rights reserved.","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73361205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Stability Study of Vata(Ficus bengalensisLinn.)Jata(Aerial Roots) Kwatha(Decoction) with Respect to Baseline Microbial Diagnostic Modalities 榕树(Ficus bengalensisLinn.)的稳定性研究芥(气根)瓜他(汤)与基线微生物诊断方式

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12004

Pravin Jawanjal, Cholera M.S., P. Bedarkar, B. Patagiri

Background:Kwatha,one of the most popular Kalpanaamongst five basic Kalpana, is widely used therapeutically as well as pharmaceutically. Although a clear description is not available in Vedicliteraturewhereasa detailed description is available in all Samhitasregarding its preparation, the proportion of water to be added, reduction in the volume of liquid,etc.Aims:To check the stability of classical liquid dosage form, Vata(Ficus Bengalensis Linn.)Jata(aerial roots)Kwatha (decoction) with respect to its microbial profile. Materials and Methods:Sample of Vata Jata Kwatha wasprepared and studied to check microbial contamination at regular intervals. Results:Sixbatchesweresubjected to the microbiological study from the date of the preparation to the date of the last microbiological study. No,any contaminations were found in the microbiological study in a minimum of one day and a maximum of 7 days after the preparation of the sample. Discussion: Hence the present study was carried out to observe the stability study of Vata Jata Kwathawith respect to Microbial Contamination of the sample prepared and preserved in different climatic and temperature conditions. Thus, a baseline Microbial profile was studied at a regular interval.At the end of the study, it was found that the shelf life of Vata Jata Kwatha was varied as per humidity and temperature.Conclusion: In the microbiological study of Vata Jata Kwatha shows its stability in a minimum of one day and a maximumofseven days after the preparation of the sample.©2022iGlobal Research and PublishingFoundation. All rights reserved

背景:Kwatha是五种基本Kalpana中最受欢迎的Kalpana之一，广泛用于治疗和制药。虽然在佛经文献中没有明确的描述，但在所有的三经中都有详细的描述，关于它的制备，要加入的水的比例，液体体积的减少等。目的:考察经典液体剂型Vata(Ficus Bengalensis Linn.)的稳定性。Jata(气根)kwata(煎剂)的微生物谱。材料与方法:制备Vata Jata Kwatha样品，定期检查微生物污染情况。结果:从制备之日起至最后一次微生物学研究之日，六批受试者接受了微生物学研究。没有。在制备样本后最少一天至最多7天内，微生物学研究中发现任何污染。讨论:因此，本研究对不同气候和温度条件下制备和保存的Vata Jata kwatha样品的微生物污染进行了稳定性研究。因此，每隔一段时间研究基线微生物谱。在研究结束时，发现Vata Jata Kwatha的保质期随着湿度和温度的变化而变化。结论:在Vata Jata Kwatha的微生物学研究中，其稳定性在样品制备后最少1天，最多7天。©2022全球研究与出版基金会。版权所有

{"title":"Stability Study of Vata(Ficus bengalensisLinn.)Jata(Aerial Roots) Kwatha(Decoction) with Respect to Baseline Microbial Diagnostic Modalities","authors":"Pravin Jawanjal, Cholera M.S., P. Bedarkar, B. Patagiri","doi":"10.35652/igjps.2022.12004","DOIUrl":"https://doi.org/10.35652/igjps.2022.12004","url":null,"abstract":"Background:Kwatha,one of the most popular Kalpanaamongst five basic Kalpana, is widely used therapeutically as well as pharmaceutically. Although a clear description is not available in Vedicliteraturewhereasa detailed description is available in all Samhitasregarding its preparation, the proportion of water to be added, reduction in the volume of liquid,etc.Aims:To check the stability of classical liquid dosage form, Vata(Ficus Bengalensis Linn.)Jata(aerial roots)Kwatha (decoction) with respect to its microbial profile. Materials and Methods:Sample of Vata Jata Kwatha wasprepared and studied to check microbial contamination at regular intervals. Results:Sixbatchesweresubjected to the microbiological study from the date of the preparation to the date of the last microbiological study. No,any contaminations were found in the microbiological study in a minimum of one day and a maximum of 7 days after the preparation of the sample. Discussion: Hence the present study was carried out to observe the stability study of Vata Jata Kwathawith respect to Microbial Contamination of the sample prepared and preserved in different climatic and temperature conditions. Thus, a baseline Microbial profile was studied at a regular interval.At the end of the study, it was found that the shelf life of Vata Jata Kwatha was varied as per humidity and temperature.Conclusion: In the microbiological study of Vata Jata Kwatha shows its stability in a minimum of one day and a maximumofseven days after the preparation of the sample.©2022iGlobal Research and PublishingFoundation. All rights reserved","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81692019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Polymers in the Design and Characterization of Sustained Release Aceclofenac Microspheres 高分子材料对乙酰氯芬酸缓释微球设计与表征的影响

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12020

Pooja D. Vaghela

Purpose:Theaim of present work was to design and characterize sustained release Aceclofenac, model drug, microspheres by emulsion solvent evaporation technique.Methods:Aceclofenac microspheres were prepared by emulsion solvent evaporation process by using Ethyl cellulose and Hydroxy propyl methyl cellulose as polymers. The microspheres were evaluated by drug release study, drug content, drug loading and encapsulation efficiency, and determination of percentage yield.Results:The present study shows that as the polymer concentration increases the percentage encapsulation efficiency, and drug content in the microsphere formulation also increases. The microspheres of all the formulated batches were spherical, discrete and free flowing. Increasing the polymer concentration in microsphere formulation decreases the rate of drug release dramatically.Conclusions:It might be concluded that drug loaded microspheres appear to be a suitable delivery system for a model drug, Aceclofenac, and may help to reduce dose of drug andfrequency of administration. Sustained release of Aceclofenac microspheres could be formulated by using ethyl cellulose and HPMC as a release retardant by emulsion solvent evaporation technique.©2022iGlobal Research and PublishingFoundation. All rights reserved

目的:采用乳化液溶剂蒸发法设计并表征模型药乙酰氯芬酸缓释微球。方法:以乙基纤维素和羟丙基甲基纤维素为聚合物，采用乳液溶剂蒸发法制备乙酰氯芬酸微球。通过药物释放、药物含量、载药量、包封率、收率等指标对微球进行评价。结果:本研究表明，随着聚合物浓度的增加，微球制剂的包封率和药物含量也随之增加。各配方批次的微球均为球形、离散、自由流动。增加微球制剂中聚合物的浓度可显著降低药物的释放速度。结论:载药微球可能是模型药物乙酰氯芬酸的一种合适的给药系统，并可能有助于减少给药剂量和给药频率。以乙基纤维素和HPMC为缓释剂，采用乳液溶剂蒸发法制备醋酸氯芬酸缓释微球。©2022全球研究与出版基金会。版权所有

{"title":"Effect of Polymers in the Design and Characterization of Sustained Release Aceclofenac Microspheres","authors":"Pooja D. Vaghela","doi":"10.35652/igjps.2022.12020","DOIUrl":"https://doi.org/10.35652/igjps.2022.12020","url":null,"abstract":"Purpose:Theaim of present work was to design and characterize sustained release Aceclofenac, model drug, microspheres by emulsion solvent evaporation technique.Methods:Aceclofenac microspheres were prepared by emulsion solvent evaporation process by using Ethyl cellulose and Hydroxy propyl methyl cellulose as polymers. The microspheres were evaluated by drug release study, drug content, drug loading and encapsulation efficiency, and determination of percentage yield.Results:The present study shows that as the polymer concentration increases the percentage encapsulation efficiency, and drug content in the microsphere formulation also increases. The microspheres of all the formulated batches were spherical, discrete and free flowing. Increasing the polymer concentration in microsphere formulation decreases the rate of drug release dramatically.Conclusions:It might be concluded that drug loaded microspheres appear to be a suitable delivery system for a model drug, Aceclofenac, and may help to reduce dose of drug andfrequency of administration. Sustained release of Aceclofenac microspheres could be formulated by using ethyl cellulose and HPMC as a release retardant by emulsion solvent evaporation technique.©2022iGlobal Research and PublishingFoundation. All rights reserved","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"217 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76720737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Indo Global Journal of Pharmaceutical Sciences

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀