Indo Global Journal of Pharmaceutical Sciences最新文献

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A Review on Updates to Increase the Residence Time of Drug in the Stomach for Gastro Retentive Drug Delivery System 胃保留给药系统中增加药物在胃中停留时间的最新进展综述

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112008

Abhishek Kumar, M. Bharkatiya

Orally-administered controlled-release drug delivery systems are associated with the shortcomings of relatively short residence times in the human stomach as well as highly variable gastrointestinal (GI) transit times. Thus, considerable intra-individual and inter-individual differences in the bioavailability of drugs are observable. There are numerous drug substances which may benefit from prolonged and controlled GI passage times. As a solution to the problem, gastroretentive drug delivery systems (GRDDS), which feature an enhanced gastric residence time (GRT), were developed. Several approaches are currently used including Floating Drug Delivery System (FDDS), swelling and expanding system, polymeric bioadhesive systems, modified-shape systems, high density system and other delayed gastric emptying devices. The drugs having absorption window in the upper part of Gastro Intestinal Tract (GIT) have enhanced bioavailability when formulated through these techniques. The recent technological development for enhancing GRT including the physiological and formulation variables affecting gastric retention, patented delivery systems, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Despite the extensive research performed in the field of GRDDS, the development, the production, and the evaluation of floating devices are still challenging. The purpose of writing this review was to compile recent literature on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Enhancing the GRT may explore new potentials of stomach as drug-absorbing organ. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

口服给药的控释药物递送系统具有在人体胃中相对较短的停留时间以及高度可变的胃肠道(GI)转运时间的缺点。因此，可以观察到药物的生物利用度在个体内和个体间存在相当大的差异。有许多药物可能受益于延长和控制胃肠道通过时间。为了解决这一问题，研究人员开发了胃保留性给药系统(GRDDS)，该系统具有延长胃停留时间(GRT)的特点。目前使用的几种方法包括浮式给药系统(FDDS)、肿胀和膨胀系统、聚合物生物粘合剂系统、修饰形状系统、高密度系统和其他延迟胃排空装置。在胃肠道上半部分具有吸收窗口的药物经这些技术配制后，生物利用度得到了提高。本文详细介绍了提高胃潴留的最新技术发展，包括影响胃潴留的生理和配方变量，专利给药系统，单单元和多单元漂浮系统的设计方法，以及它们的分类和配方方面。尽管在GRDDS领域进行了广泛的研究，但浮动装置的开发、生产和评估仍然具有挑战性。撰写这篇综述的目的是汇编最近关于提高胃停留时间(GRT)的药物方法的文献。增强胃的GRT，可以发掘胃作为药物吸收器官的新潜力。©2020全球研究与出版基金会。版权所有。

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引用次数: 0

Comparative Study of Conventional and Fatty Acid Vesicular Systems – An Overview 传统和脂肪酸囊泡系统的比较研究综述

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112011

Gayathri Devi K, Lakshmi Pk

: Fatty acid vesicles are suspensions of closed lipid bilayers that are composed of fatty acids and their ionized species which are restricted to a narrow pH range. The fatty acid molecules are oriented in such a way that their hydrocarbon tails are directed toward the membrane interior and the carboxyl groups are in contact with water. Recent innovations provide an opportunity to formulate fatty acid vesicles with distinguishing features such as extension of pH range, insensitivity toward divalent cations, easy alteration in membrane composition, very simple systems in terms of chemical nature and enhanced stability properties. This review contains detail about the present stature of fatty acid vesicles, comparative study of fatty acid vesicles with conventional liposomes, unique features of fatty acid vesicles (dynamicity, stability, matrix effect etc.,) and key evaluation parameters of fatty acid vesicles. Fatty acid vesicles were found to have high penetration capacity, good bio-distribution properties, increased diffusion rate and optimum drug deposition nature than other vesicular forms. They have various applications in transdermal delivery, follicular delivery and in brain targeting drug delivery systems (drugs that are unable to cross blood brain barrier due to high solubility). This review focuses on various researches conducted on fatty acid vesicles with reference to its formulation and evaluation parameters. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

脂肪酸囊泡是封闭脂质双分子层的悬浮液，由脂肪酸及其电离物质组成，这些物质被限制在一个狭窄的pH范围内。脂肪酸分子以这样一种方式定向，即它们的碳氢化合物尾部指向膜内部，羧基与水接触。最近的创新为脂肪酸囊泡的制备提供了机会，这些囊泡具有独特的特征，如pH范围的扩展、对二价阳离子的不敏感、膜组成的容易改变、化学性质非常简单的系统和增强的稳定性。本文综述了脂肪酸囊泡的现状、脂肪酸囊泡与常规脂质体的比较研究、脂肪酸囊泡的独特性(动态性、稳定性、基质效应等)以及脂肪酸囊泡的关键评价参数。脂肪酸囊泡比其他囊泡具有高渗透能力、良好的生物分布特性、更快的扩散速率和最佳的药物沉积性质。它们在透皮递送、滤泡递送和脑靶向药物递送系统(由于高溶解度而无法穿过血脑屏障的药物)中有各种应用。本文综述了脂肪酸囊泡的各种研究进展，并对其配方和评价参数进行了综述。©2020全球研究与出版基金会。版权所有。

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引用次数: 0

Anti-Inflammatory Effect of Neuracanthus Sphaerostachyus Dalz. Leaves on Experimental Colitis in Rats 球棘神经棘的抗炎作用。实验性结肠炎大鼠的叶片

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111002

Dang Dk, Patel Nj

essential ABSTRACT: Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder with unknown etiology affecting the GI tract. Neuracanthus sphaerostachyus has been traditionally used for the treatment of skin diseases, cough, and asthma in various forms orally. Lack of sufficient scientific evidence indicating the utility of this plant in the treatment of ulcerative colitis prompted us to investigate the anti-inflammatory activity of the plant on experimental colitis in rats. In-vivo pharmacological screening method for evaluation of anti-inflammatory activity of the methanolic and aqueous extract of Neuracanthus sphaerostachyus leaves at doses of 125, 250, and 500 mg/kg was assessed by TNBS-induced ulcerative colitis in Wistar rats. Colitis was induced by intra-rectal instillation of 10 mg of tri-nitro benzene sulphonic acid (TNBS) in 0.25 ml of 50% ethanol (v/v) followed by treatments with 7 d for various extracts and then animals were sacrificed to remove colon for histopathology, macroscopic scoring, and biochemical assays. The 7 d treatment with a methanolic and aqueous extract of Neuracanthus sphaerostachyus significantly improved feed intake and body weight with a decrease in macroscopical score, colonic MPO, LPO and, TNF-α. The findings from the histopathological study support the above results by its potential to protect the colonic mucosal damage. The present study exhibits anti-inflammatory potential of methanolic and aqueous extracts of Neuracanthus sphaerostachyus leaves in TNBS induced experimental colitis and it can be beneficial for patients suffering from ulcerative colitis. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

摘要:炎症性肠病(IBD)是一种影响胃肠道的慢性特发性炎症性疾病，病因不明。球囊神经棘传统上被用于治疗各种形式的皮肤病、咳嗽和哮喘。由于缺乏足够的科学证据表明该植物在治疗溃疡性结肠炎方面的效用，因此我们研究了该植物对实验性结肠炎大鼠的抗炎活性。采用体内药理学筛选法评价125、250、500 mg/kg剂量下球囊叶甲醇和水提物的抗炎活性，采用tnbs诱导Wistar大鼠溃疡性结肠炎。以0.25 ml 50%乙醇(v/v)配制三硝基苯磺酸(TNBS)，经直肠内滴注10 mg致结肠炎后，用各种提取物处理7 d，处死动物切除结肠，进行组织病理学、宏观评分和生化检测。经甲醇和水提物处理第7 d，可显著提高采食量和体重，降低宏观评分、结肠MPO、LPO和TNF-α。组织病理学研究结果支持了上述结果，证明其具有保护结肠粘膜损伤的潜力。本研究表明，球囊神经棘叶甲醇和水提物对TNBS诱导的实验性结肠炎具有抗炎作用，对溃疡性结肠炎患者有益。©2020全球研究与出版基金会。版权所有。

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引用次数: 6

A Comparative Study between Aqueous and Ethanolic Extracts of Allium Odorum Linn with Reference to its Antioxidant and AlphaAmylase Inhibition Activities 香蒜水提液与醇提液抗氧化及α淀粉酶抑制活性的比较研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111008

N. Talukdar, R. Devi, Indrani Barman

引用次数: 1

Solid Lipid Nanoparticles: A Review 固体脂质纳米颗粒:综述

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112004

M. Begum, N. B. Shaik

引用次数: 1

From Conventional Treatment to Targeted Antimalarial Therapy: Building Up on Innovations 从常规治疗到靶向抗疟治疗:在创新的基础上建立

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111003

S. Akash, Gupta Pritee

: Despite many technological advancements and innovations, infectious disease like malaria continues to be one of the greatest health challenges worldwide. The conventional drug therapy has various limitations. There are various challenges faced by drug therapy and the eradication agenda. However, various new strategies are being investigated not only to treat the parasitic disease but to prevent its spread and relapse. Nanotechnology-based approaches (diagnosis treatment and prevention), reconsidering drugs with limitations, repurposing of drugs, and development of new drugs by modifying existing compounds, re-optimizing available antimalarial, creating new combinations, etc. are some of them. The use of herbal drugs for antimalarial therapy has provided a novel approach having lesser side effects, safety, and more efficacies. Recent developments like investigating new targets for antimalarial drugs, newer and more effective mechanisms for attacking the parasite, targeting organ system and multiple stages of the parasitic life cycle and many other newer approaches may revolutionize the way we are fighting the malaria parasite soon. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

*尽管有许多技术进步和创新，但疟疾等传染病仍然是全世界最大的健康挑战之一。传统的药物治疗有很多局限性。药物治疗和根除议程面临各种挑战。然而，人们正在研究各种新的策略，不仅是为了治疗这种寄生虫病，而且是为了防止它的传播和复发。其中一些是基于纳米技术的方法(诊断、治疗和预防)、重新考虑有局限性的药物、重新利用药物、通过修改现有化合物开发新药、重新优化现有抗疟药、创造新的组合等。使用草药进行抗疟治疗提供了一种副作用更小、更安全、更有效的新方法。最近的进展，如研究抗疟药物的新靶点，攻击寄生虫的更新和更有效的机制，针对器官系统和寄生虫生命周期的多个阶段，以及许多其他更新的方法，可能很快就会彻底改变我们对抗疟疾寄生虫的方式。©2020全球研究与出版基金会。版权所有。

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引用次数: 1

Review on Nanosponges- A Versatile Drug Delivery System 纳米海绵——一种多功能给药系统的研究进展

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111007

G. Harsha, N. B. Shaik

Target effective drug delivery systems are the novel approach for delivering various active moieties to targeted site. Targeting active moieties to a specific site is achieved by appropriate nanotechnology as targeted drug delivery system has various drawbacks. In order to combat this problem various dosage forms have been developed with nanotechnology among those the one with discrete functionalized particles are called as Nanosponges. Nanosponges are porous polymeric nanoparticles which are spherical in shape about a size of virus and can load wide variety of drugs. These nanoparticles with nanosize circulate rapidly in the body till they achieve specific target site and release drug in predictable and sustained manner. A detailed introduction about nanosponges and its various advantages when compared with vesicular systems, its mechanism of drug release, various drugs formulated as nanosponges, preparation and evaluations of nanosponges with applications in pharmacy are provided. This article provides a clear cut view of nanosponges and its targeted delivery, by which drugs with low solubility, bioavailability and adverse effects can easily formulated by overcoming all these problems. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Harsha, G.; Shaik, N.B. Review on NanospongesA Versatile Drug Delivery System. Indo Global J. Pharm. Sci., 2021; 11(1): 47-55. DOI: http://doi.org/10.35652/IGJPS.2021.111007 . Indo Global Journal of Pharmaceutical Sciences, 2021; 11(1): 47-55 48 colloidal nature and reported to have high solubilization capacity of poorly water soluble drug which provide sustained release as well as improving drug bioavailability. Because of their inner hydrophobic and outer hydrophilic branching, they are able to load both hydrophilic and hydrophobic drug molecules offering unparalleled flexibility[4]. COMPOSITION AND STRUCTURE OF

靶向有效药物递送系统是一种将各种活性成分递送到目标部位的新方法。靶向药物递送系统存在各种缺陷，因此通过适当的纳米技术可以将活性部分靶向到特定位点。为了解决这一问题，人们利用纳米技术开发了各种剂型，其中具有离散功能化颗粒的剂型被称为纳米海绵。纳米海绵是多孔的聚合纳米颗粒，其形状与病毒大小相当，可以装载多种药物。这些纳米颗粒在体内快速循环，直到到达特定的靶点，并以可预测和持续的方式释放药物。本文详细介绍了纳米海绵及其与囊泡系统相比的各种优势、纳米海绵的药物释放机制、各种纳米海绵制剂、纳米海绵的制备和评价及其在药学上的应用。本文提供了纳米海绵及其靶向递送的清晰视角，通过克服这些问题，可以很容易地配制出低溶解性、低生物利用度和不良反应的药物。©2020全球研究与出版基金会。版权所有。引用本文如下:Harsha, G.;纳米海绵——一种多功能给药系统的研究进展。印度国际制药公司。科学。, 2021;11(1): 47-55。DOI: http://doi.org/10.35652/IGJPS.2021.111007。印度全球药物科学杂志，2021;11(1): 47-55 48胶体性质，据报道对水溶性差的药物具有高的增溶能力，提供缓释并提高药物的生物利用度。由于其内部疏水和外部亲水分支，它们能够装载亲水性和疏水性药物分子，具有无与伦比的灵活性[4]。的组成和结构

{"title":"Review on Nanosponges- A Versatile Drug Delivery System","authors":"G. Harsha, N. B. Shaik","doi":"10.35652/igjps.2021.111007","DOIUrl":"https://doi.org/10.35652/igjps.2021.111007","url":null,"abstract":"Target effective drug delivery systems are the novel approach for delivering various active moieties to targeted site. Targeting active moieties to a specific site is achieved by appropriate nanotechnology as targeted drug delivery system has various drawbacks. In order to combat this problem various dosage forms have been developed with nanotechnology among those the one with discrete functionalized particles are called as Nanosponges. Nanosponges are porous polymeric nanoparticles which are spherical in shape about a size of virus and can load wide variety of drugs. These nanoparticles with nanosize circulate rapidly in the body till they achieve specific target site and release drug in predictable and sustained manner. A detailed introduction about nanosponges and its various advantages when compared with vesicular systems, its mechanism of drug release, various drugs formulated as nanosponges, preparation and evaluations of nanosponges with applications in pharmacy are provided. This article provides a clear cut view of nanosponges and its targeted delivery, by which drugs with low solubility, bioavailability and adverse effects can easily formulated by overcoming all these problems. © 2020 iGlobal Research and Publishing Foundation. All rights reserved. Cite this article as: Harsha, G.; Shaik, N.B. Review on NanospongesA Versatile Drug Delivery System. Indo Global J. Pharm. Sci., 2021; 11(1): 47-55. DOI: http://doi.org/10.35652/IGJPS.2021.111007 . Indo Global Journal of Pharmaceutical Sciences, 2021; 11(1): 47-55 48 colloidal nature and reported to have high solubilization capacity of poorly water soluble drug which provide sustained release as well as improving drug bioavailability. Because of their inner hydrophobic and outer hydrophilic branching, they are able to load both hydrophilic and hydrophobic drug molecules offering unparalleled flexibility[4]. COMPOSITION AND STRUCTURE OF","PeriodicalId":13366,"journal":{"name":"Indo Global Journal of Pharmaceutical Sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84278532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review: p-Coumaric Acid, A Medicinally Important Phenolic Acid Moiety 对香豆酸是一种重要的药用酚酸片段

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112007

S. Sharma, A. Khatkar, S. Kakkar

p-Coumaric acid is an ubiquitous natural phenolic phytochemical mainly exist in two forms trans- and cis-p-coumaric acid. It occurs in free as well as in bound forms, is a common dietary polyphenol distributed in fruits, vegetables and cereals. It was considered as a powerful antioxidant and widely reported to demonstrate antimicrobial, antifungal, anticancer, antidiabetic, anti-inflammatory, antiviral, antihypertensive, antiulcer, antiprotozoal and antimelanogenic. This review contains the fundamental information about biological potential, common pathway utilized, SAR, wide source of p-coumaric acid and evidence of their role in disease prevention. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

对香豆酸是一种普遍存在的天然酚类植物化学物质，主要以反式和顺式对香豆酸两种形式存在。它以游离和结合的形式存在，是一种常见的膳食多酚，分布在水果、蔬菜和谷物中。它被认为是一种强大的抗氧化剂，并被广泛报道具有抗菌、抗真菌、抗癌、抗糖尿病、抗炎、抗病毒、抗高血压、抗溃疡、抗原虫和抗黑色素瘤的作用。本文综述了对香豆酸的生物学潜力、常用途径、SAR、广泛来源及其在疾病预防中的作用。©2020全球研究与出版基金会。版权所有。

引用次数: 0

Biosynthesis, Characterization and Biological Studies of Copper Nanoparticles from Methanolic Extract of Bulb of Zephyranthes citrina 西风球茎甲醇提取物纳米铜的合成、表征及生物学研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112012

Prakash Jayavel, V. Subramaniam

This work reports the biosynthesis, characterization and biological studies of copper oxide nanoparticles using a methanolic extract of bulb of Zephyranthes citrina. The synthesised copper oxide nanoparticles were characterized by using various spectral techniques. The functional, structural and morphological studies were confirmed by FT-IR, XRD and SEM respectively. The elemental composition was determined by EDAX analysis. The various spectral data confirms the formation of copper oxide nanoparticles and is found to be orthorhombic, 18-50 nm of size and spherical in shape. The synthesised copper oxide nanoparticles were investigated for antibacterial activity against gram positive (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermidis), gram negative (Salmonella typhi, Escherichia coli and Klebseilla pneumoniae) and antifungal (Aspergillus niger, Candida albicans and Fusarium oxysporum) activities with different pathogens. The results revealed that copper oxide nanoparticles exhibit excellent inhibition efficiency against representative microorganisms. The outcome of the study could be useful for the development of value added products from indigenous medicinal plants. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

本文报道了利用西风球茎甲醇提取物制备氧化铜纳米颗粒的生物合成、表征和生物学研究。利用各种光谱技术对合成的氧化铜纳米粒子进行了表征。通过FT-IR、XRD和SEM对其进行了功能、结构和形态研究。元素组成用EDAX分析测定。各种光谱数据证实了氧化铜纳米颗粒的形成，并且发现它们是正交的，尺寸为18- 50nm，形状为球形。研究了合成的氧化铜纳米颗粒对革兰氏阳性(金黄色葡萄球菌、枯草芽孢杆菌和表皮葡萄球菌)、革兰氏阴性(伤寒沙门氏菌、大肠杆菌和肺炎克雷伯菌)和抗真菌(黑曲霉、白色念珠菌和尖孢镰刀菌)不同病原菌的抑菌活性。结果表明，氧化铜纳米颗粒对代表性微生物具有良好的抑制效果。研究结果可为本地药用植物的增值产品开发提供参考。©2020全球研究与出版基金会。版权所有。

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引用次数: 1

Effect of Solanum melongena Linn. Leaves Extracts on Clonidine Induced Catalepsy and Milk Induced Leukocytosis and Eosinophilia in Mice 龙葵的药效。叶提取物对可乐定致小鼠猝睡和乳致小鼠白细胞增多和嗜酸性粒细胞增多的影响

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112005

Ramdas N. Kale, Ravindra Y. Patil

Objective: To study the Effect of Solanum melongena Linn. leaves extracts on Clonidine induced catalepsy and milk induced Leukocytosis and Eosinophilia in mice. Methods: Methanolic and chloroform extracts of Solanum melongena Linn. leaves were prepared. Preliminary phytochemical screening of the prepared extracts was carried out. Effects of prepared extracts were studied on Clonidine induced catalepsy and milk induced leukocytosis and eosinophila in mice. Results: Maximum duration of catalepsy was observed at 90 min after the clonidine administration. There was significant inhibition (p˂0.05) of clonidine induced catalepsy in the animals pretreated with chlorpheniramine maleate, methanol and chloroform extract of S. melongena. Administration of milk (4mg/kg) subcutaneous route exhibited significant increase in leucocyte and eosinophil count after 24 hrs of administration. Chloroform extract at the dose of 500mg/kg body weight showed significant inhibition (p˂0.05) of milk induced leukocytosis and eosinophilia. Conclusions: These results suggest that Solanum melongena leaves extract may have the potential therapeutic value in the treatment of allergic diseases. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

目的:研究龙葵提取物的药理作用。叶提取物对可乐定致小鼠猝睡和牛奶致小鼠白细胞增多和嗜酸性粒细胞增多的影响。方法:采用龙葵的甲醇提取液和氯仿提取液。叶子准备好了。对制备的提取物进行了初步的植物化学筛选。研究了所制提取物对可乐定致小鼠猝睡和乳致小鼠白细胞和嗜酸性粒细胞的影响。结果:在给药后90min，观察到最大的麻痹持续时间。用马来酸氯苯那敏、甲醇和龙葵氯仿提取物预处理后，可显著抑制可乐定诱导的动物猝睡(p小于0.05)。皮下给药牛奶(4mg/kg) 24小时后，白细胞和嗜酸性粒细胞计数显著增加。500mg/kg体重剂量的氯仿提取物对牛奶诱导的白细胞增多和嗜酸性粒细胞增多有显著抑制作用(p小于0.05)。结论:龙葵叶提取物在过敏性疾病的治疗中具有潜在的治疗价值。©2020全球研究与出版基金会。版权所有。

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引用次数: 1

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