Indo Global Journal of Pharmaceutical Sciences最新文献_第4页

Natural Gums and Carbohydrate-Based Polymers: Potential Encapsulants 天然树胶和碳水化合物基聚合物:潜在的包封剂

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12001

Z. Ansari, S. Goomer

Plants possess a wide range of bioactive compounds with established health benefits which are highly susceptible to degradation. The environmental dynamics such as high temperature, light, oxygen limits the shelf life and bioavailability of these compounds in food and drug formulations. Encapsulation serves as an effective way of preserving these sensitive compounds by enclosing them within a coating/wall material and hence improves their bioavailability and functional properties.Scope and Approach: The wall materials used for encapsulation also known as encapsulants act as physical barriers between core compound and external stimuli. There are different edible protein, lipid and carbohydrate based encapsulants used for coating of bioactive compounds. However, this review gives a detailed insight on composition, functional properties, and applications of carbohydrate based polymers in food, and pharmaceutical industries while emphasizing on the advantages and limitations of these polymers in encapsulation process. So, we explored recent expansion in the area of natural polysaccharides and their derivatives as carriers for the targeted and sustained delivery of active compounds. Key Findings and Conclusions:Polysaccharides, natural gums (Carrageenan, Alginate, Gum arabic, Guar gum, Gellan gum, Xanthan gum) and their derivatives are biodegradable polymers being used as sustained release carriers. They are more advantageous over lipid based and protein based carriers by virtue of their unique features such as thermo stability and versatility of interacting with a range of hydrophilic and hydrophobic compounds. Tailor-made carriers made by structural modifications of the polysaccharides using physical, chemical and enzymatic reactions result in improved functional properties and hence widen their area of applications.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Ansari, Z.; Goomer, S.Natural gums and carbohydrate-based polymers: Potential encapsulants. Indo Global J. Pharm. Sci., 2022; 12:1-20. DOI:http://doi.org/10.35652/IGJPS.2022.12001.

植物具有广泛的生物活性化合物，具有公认的健康益处，但极易降解。环境动力学如高温、光、氧限制了这些化合物在食品和药物制剂中的保质期和生物利用度。包封是一种有效的保存这些敏感化合物的方法，通过将它们包裹在涂层/壁材中，从而提高它们的生物利用度和功能特性。范围和方法:用于封装的壁材也称为封装剂，作为核心化合物和外部刺激之间的物理屏障。有不同的可食用的蛋白质、脂质和碳水化合物包被剂用于生物活性化合物的包被。然而，本文综述了碳水化合物基聚合物的组成、功能特性及其在食品和制药工业中的应用，并强调了这些聚合物在封装过程中的优点和局限性。因此，我们探索了天然多糖及其衍生物作为靶向和持续递送活性化合物载体的最新扩展领域。主要发现与结论:多糖、天然胶(卡拉胶、海藻酸胶、阿拉伯胶、瓜尔胶、结冷胶、黄原胶)及其衍生物是可生物降解的聚合物，可作为缓释载体。由于其独特的特性，如热稳定性和与一系列亲水和疏水化合物相互作用的通用性，它们比基于脂质和基于蛋白质的载体更有优势。利用物理、化学和酶促反应对多糖进行结构修饰而制成的特制载体，改善了多糖的功能特性，从而拓宽了其应用领域。©2022全球研究与出版基金会。版权所有。引用本文如下:Ansari, Z.;天然树胶和碳水化合物基聚合物:潜在的包封剂。印度国际制药公司。科学。, 2022;12:1-20。DOI: http://doi.org/10.35652/IGJPS.2022.12001。

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引用次数: 4

FTIR and GCMS analysis of Euphorbia hirtaL. and its In-vitroAntibacterial and Antioxidant Activities 大戟的FTIR和GCMS分析。及其体外抗菌和抗氧化活性

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12009

D. Kain, Suresh Kumar, Vandana, Amrita Suryavanshi, Atul Arya

Introduction: Euphorbia hirtaL. is a common weed plant belongs to family Euphorbiaceae. Thepresent study brings out the importance of weed plants like E. hirtain medicine and health thecare system. Material and Methods:Plant E. hirtahas been collected from thegarden of Department of Botany, University of Delhi and plant leaves were extractedin ethanol by thesoxhlet method. Antibacterial screening has been done by disc-diffusion method. Theantioxidant potential has been determined by TPC, TFC, FRAP, Total antioxidants through phosphomolybdate assay and by DPPH radical scavenging activity. FTIR and GCMS analysis havebeen done for characterization.Result and Discussions:Plant E. hirtashowed significant antibacterial activity against Escherichia coli,Staphylococcus aureus, Bacilus subtilisand Pseudomonas aeruginosawith maximum ZOI diameter 19±0.5mmagainst S.aureusandP.aeruginosaboth. Plant E. hirtaL. showedsignificant antioxidant potential with 196.32 mg/g, 39.7133 mg/g, 595.99 mg/g, 525.84 mg/g values for TPC, TFC, FRAP activity and total antioxidants through phosphomolybdate assay respectively. Plant E. hirtaalso showedsignificant radical scavenging activity against DPPH free radical with amaximum % inhibition 68.505% at 1000μg/ml concentration. FTIR and GCMS of plant E. hirtahave confirmed the presence of various active functional groups and compounds.Conclusion:The current study justifies the importance of E. hirta L. a common weed asasource of natural antioxidants having antibacterial potential and its role in herbal medicines.©2022iGlobal Research and PublishingFoundation. All rights reserved.

简介:大戟属植物。是一种常见的杂草植物，属于大戟科。本文的研究结果揭示了黄芪等杂草植物在医药和保健系统中的重要作用。材料与方法:采自印度德里大学植物学系植物园内，采用乙醇提取法提取植物叶片。采用圆盘扩散法进行抗菌筛选。通过磷酸钼酸盐测定TPC、TFC、FRAP、总抗氧化剂和DPPH自由基清除活性测定其抗氧化能力。FTIR和GCMS分析已完成表征。结果与讨论:对大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌和铜绿假单胞菌均有显著的抑菌活性，对金黄色葡萄球菌和铜绿假单胞菌的ZOI最大直径为19±0.5mm。植物E. hirtaL。经磷钼酸盐测定，其TPC、TFC、FRAP活性和总抗氧化剂分别为196.32 mg/g、39.7133 mg/g、595.99 mg/g、525.84 mg/g，具有显著的抗氧化潜力。在浓度为1000μg/ml时，对DPPH自由基的抑制率最高达68.505%。经红外光谱和气相色谱分析，证实其含有多种活性官能团和化合物。结论:本研究证实了一种常见的杂草——赤藓属植物作为一种具有抗菌潜力的天然抗氧化剂的重要性及其在中草药中的作用。©2022全球研究与出版基金会。版权所有。

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引用次数: 1

Disporum Cantoniense(Lour.) Merr.: An Overview and Study of Traditional Use Disporum Cantoniense不悦之色。稳定。:传统用法综述与研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12034

S. Regmi, Kmensiful Binan, Himal Barakoti, Rajeev K. Singla

Over the past two decades, there has been a tremendous increase in the use of indigenous herbal medicinal plants in modern medicine; however, there is still a significant lack of research data in this field. This incomprehensive information base shades thedevelopment of a comprehensive research agenda especially in the context of developing Asian countries like Nepal. This chapter gives an overview of traditional medicinal plant Disporum Cantoniense,which is called hadjora (bone-joining) in Nepaliandhasbeen used since time unmemorable in case of bone fracture. Apart from this, D. cantoniense has various other medicinal uses in other regions around the globe. This chapter deals with overall aspects of D. cantoniense with sequential demystification thus enabling a greater understanding of its use and possibility to be used as alternative medicine in the future.©2022Caproslaxy Media. All rights reserved.

在过去的二十年里，在现代医学中使用本土草药植物有了巨大的增长;然而，这一领域的研究数据仍然严重缺乏。这种不全面的信息库影响了全面研究议程的发展，特别是在尼泊尔等亚洲发展中国家的背景下。本章概述了传统药用植物广东菊，它在尼泊尔被称为hajora(骨连接)，自骨折以来一直被使用。除此之外，广东菌在全球其他地区也有多种其他药用用途。本章以循序渐进的方式全面介绍广东菜，从而更好地了解它的用途和将来作为替代药物使用的可能性。©2022 caproslaxy媒体。版权所有。

引用次数: 1

Lung Cancer: How Well We Have Fared? 肺癌:我们的进展如何?

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12007

Pradeep S. Patil, Hitendra S. Mahajan

Lung Cancer has been one of the most common causes of death worldwide. With the death toll increasing in millions every year globally it has become a global scourge. With poor prognosis and disappointing 5 years survival rate post diagnosis, treatment for this disease has been ambiguous. Various advances in treatment are being made but till date the 5 years survival for major patients remains a dream. This review encompasses different treatment options that are available, problems associated with treatment and future perspective for the treatment of lung cancer. ©2022iGlobal Research and PublishingFoundation. All rights reserved.

引用次数: 1

In vitroCytotoxic Activity of a Sulphated Polysaccharide Ulvan against Human Breast and Glioblastoma Cell line 硫酸多糖Ulvan对人乳腺和胶质母细胞瘤细胞系的毒性研究

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2022-01-01 DOI: 10.35652/igjps.2022.12012

K. Sonia, K. Meena, S. Bai

This study was designed to evaluate the hemolysis, anti-inflammatoryand cytotoxicityactivity of sulphated polysaccharideulvan extracted from greenseaweed Ulvalactuca(UL).Ulvan was extracted and characterized with UV-Visible Spectroscopy, Fourier transform infraredspectroscopy (FTIR) and Scanning electron microscopy(SEM).Total uronic acid and sulphate content were found to be 19.38% w/w and 22.53% w/w.The biocompatibilityof the sulphated polysaccharide ulvan wasevaluatedviahemolysis, its interaction with erythrocyte structure and anti-inflammatory studies.Further,thepolysaccharide was treated for cellular toxicityagainsthuman breast cancer(MCF-7)and human glioblastoma cancer (U87) cell linesusing the 3-(4, 5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assaymethod.This study indicates that the sulphated polysaccharide ulvanwas more suitable for biomedical applications with promising chemo preventive and chemotherapeutic activity.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Sonia, K.; Meena, K.S.; Alamelu Bai, S.In vitro Cytotoxic Activity of a Sulphated Polysaccharide Ulvan against Human Breast and Glioblastoma Cell line.Indo Global J. Pharm. Sci., 2022; 12:122-127. DOI:http://doi.org/10.35652/IGJPS.2022.12012.

本研究旨在评价从绿海藻Ulvalactuca(UL)中提取的硫酸盐多糖的溶血、抗炎和细胞毒活性。利用紫外可见光谱、傅里叶变换红外光谱和扫描电镜对其进行了提取和表征。总糖醛酸和硫酸盐含量分别为19.38%和22.53%。通过溶血作用、与红细胞结构的相互作用和抗炎研究来评价硫酸盐多糖的生物相容性。此外，采用3-(4,5 -二甲基噻唑-2-基)-2,5-二苯基溴化四唑(MTT)检测方法对该多糖对人乳腺癌(MCF-7)和人胶质母细胞瘤(U87)细胞系的细胞毒性进行了研究。该研究表明，磺化乌尔万多糖具有良好的化学预防和化疗活性，更适合生物医学应用。©2022全球研究与出版基金会。版权所有。引用本文如下:Sonia, K.;之一Meena K.S.;硫酸多糖Ulvan对人乳腺和胶质母细胞瘤细胞的体外细胞毒活性。印度国际制药公司。科学。, 2022;12:122 - 127。DOI: http://doi.org/10.35652/IGJPS.2022.12012。

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引用次数: 1

Role of Diet and Salvia miltiorrhiza to Manage Osteoporosis 饮食和丹参对骨质疏松症的治疗作用

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111006

Shelly Garg, L. Sharma, Hardik Dalal

: The main aim of this study is to get information about the effect of Salvia miltiorrhiza on the bone health of individuals affected from osteoporosis, and also the prevalence of osteoporosis in the different parts of the globe and also to find out its effects and the group of people affected. Different studies are being carried out to find the method of reduction of stiffness and pain in the joints. Osteoporosis is a silent disease and symptoms are not easily visible until complete development, but the major symptom is bone fracture even when a little force is exerted on the bone. It affects a total combined population of about 75 millions in Japan, Europe and USA. The combined highest prevalence of osteoporosis is of America and Europe, which is of around 51 percent of the total global population. This rapid increase in the number of cases every year makes it important for us to gain information

本研究的主要目的是了解丹参对骨质疏松症患者骨骼健康的影响，以及全球不同地区骨质疏松症的患病率，并找出其效果和受影响的人群。人们正在进行不同的研究，以找到减轻关节僵硬和疼痛的方法。骨质疏松症是一种无声的疾病，直到完全发育时才容易出现症状，但即使对骨骼施加一点力，其主要症状也是骨折。它影响了日本、欧洲和美国总计约7500万人口。骨质疏松症发病率最高的地区是美国和欧洲，约占全球总人口的51%。每年病例数量的快速增长使得我们获得信息变得非常重要

引用次数: 0

Evaluation of Acute Dermal Irritation, Sensitization and Acute Dermal Toxicity of Leather Cream in Laboratory Animals 皮膏对实验动物的急性皮肤刺激、致敏和急性皮肤毒性评价

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.113001

Atul Adhikari, Himal Barakoti, Biplab Kumar Dey

Unused leather products attract fungal invasion and deteriorate the product lifespan. The development of antifungal leather cream/polish can solve this array considered that the prepared formulation is skin friendly. Possible adhesion of leather cream to the skin may provide a route for entry of hazardous and harmful ingredients. In this study, leather cream prepared in the laboratory and a marketed product of leather cream were tested for acute dermal irritation in rabbits, skin sensitization in guinea pigs, and acute dermal toxicity in rats. Draize dermal irritation scoring system was used to examine the condition of erythema and edema in rabbits at intervals of 24, 48 and 72 hours. Percentage sensitization rate, sensitization grade, sensitization classifications were accessed in guinea pigs after 24 hours of dermal exposure. Rats were observed daily for 14 days to detect any signs of irritation, change in general behavior, toxicity, morbidity and mortality. Histological examination of rat’s skin was performed at the end of the study. No any kind of dermal responses or any observable signs of systemic toxicity were detected in rabbits treated with either of the leather cream samples. No sensitization, erythema or edema was observed in guinea pigs. In the case of rats, the skin was normal with negative signs of toxicity, erythema or edema. Histological study also failed to show any damage in skin tissue layers of rats applied with test materials. The result provides a base for development of anti-fungal leather cream/polish which can enhance the life of leather and avoid the fungal invasion upon storing for a period of time. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

未使用的皮革制品会吸引真菌入侵，降低产品寿命。考虑到所制备的配方对皮肤友好，抗菌皮革面霜/抛光剂的开发可以解决这一问题。皮革面霜可能与皮肤粘连，可能为有害成分的进入提供途径。在本研究中，对实验室制备的皮革霜和市场上销售的皮革霜产品进行了兔急性皮肤刺激、豚鼠皮肤致敏和大鼠急性皮肤毒性的测试。采用Draize皮肤刺激评分系统，每隔24、48、72小时观察兔的红斑、水肿情况。在豚鼠皮肤暴露24小时后获取致敏率百分比、致敏等级、致敏分类。每天观察大鼠14天，以检测任何刺激迹象、一般行为变化、毒性、发病率和死亡率。研究结束时对大鼠皮肤进行组织学检查。没有任何种类的皮肤反应或任何可观察到的全身毒性的迹象，在兔子处理的皮革霜样品。豚鼠未见致敏、红斑或水肿。在大鼠的情况下，皮肤正常，有毒性，红斑或水肿的阴性迹象。组织学研究也未发现大鼠皮肤组织层有任何损伤。研究结果为开发抗真菌皮革膏/上光剂提供了基础，可以提高皮革的使用寿命，避免真菌在皮革存放一段时间后的入侵。©2020全球研究与出版基金会。版权所有。

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引用次数: 0

A Review on Updates to Increase the Residence Time of Drug in the Stomach for Gastro Retentive Drug Delivery System 胃保留给药系统中增加药物在胃中停留时间的最新进展综述

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112008

Abhishek Kumar, M. Bharkatiya

Orally-administered controlled-release drug delivery systems are associated with the shortcomings of relatively short residence times in the human stomach as well as highly variable gastrointestinal (GI) transit times. Thus, considerable intra-individual and inter-individual differences in the bioavailability of drugs are observable. There are numerous drug substances which may benefit from prolonged and controlled GI passage times. As a solution to the problem, gastroretentive drug delivery systems (GRDDS), which feature an enhanced gastric residence time (GRT), were developed. Several approaches are currently used including Floating Drug Delivery System (FDDS), swelling and expanding system, polymeric bioadhesive systems, modified-shape systems, high density system and other delayed gastric emptying devices. The drugs having absorption window in the upper part of Gastro Intestinal Tract (GIT) have enhanced bioavailability when formulated through these techniques. The recent technological development for enhancing GRT including the physiological and formulation variables affecting gastric retention, patented delivery systems, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Despite the extensive research performed in the field of GRDDS, the development, the production, and the evaluation of floating devices are still challenging. The purpose of writing this review was to compile recent literature on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Enhancing the GRT may explore new potentials of stomach as drug-absorbing organ. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

口服给药的控释药物递送系统具有在人体胃中相对较短的停留时间以及高度可变的胃肠道(GI)转运时间的缺点。因此，可以观察到药物的生物利用度在个体内和个体间存在相当大的差异。有许多药物可能受益于延长和控制胃肠道通过时间。为了解决这一问题，研究人员开发了胃保留性给药系统(GRDDS)，该系统具有延长胃停留时间(GRT)的特点。目前使用的几种方法包括浮式给药系统(FDDS)、肿胀和膨胀系统、聚合物生物粘合剂系统、修饰形状系统、高密度系统和其他延迟胃排空装置。在胃肠道上半部分具有吸收窗口的药物经这些技术配制后，生物利用度得到了提高。本文详细介绍了提高胃潴留的最新技术发展，包括影响胃潴留的生理和配方变量，专利给药系统，单单元和多单元漂浮系统的设计方法，以及它们的分类和配方方面。尽管在GRDDS领域进行了广泛的研究，但浮动装置的开发、生产和评估仍然具有挑战性。撰写这篇综述的目的是汇编最近关于提高胃停留时间(GRT)的药物方法的文献。增强胃的GRT，可以发掘胃作为药物吸收器官的新潜力。©2020全球研究与出版基金会。版权所有。

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引用次数: 0

Comparative Study of Conventional and Fatty Acid Vesicular Systems – An Overview 传统和脂肪酸囊泡系统的比较研究综述

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.112011

Gayathri Devi K, Lakshmi Pk

: Fatty acid vesicles are suspensions of closed lipid bilayers that are composed of fatty acids and their ionized species which are restricted to a narrow pH range. The fatty acid molecules are oriented in such a way that their hydrocarbon tails are directed toward the membrane interior and the carboxyl groups are in contact with water. Recent innovations provide an opportunity to formulate fatty acid vesicles with distinguishing features such as extension of pH range, insensitivity toward divalent cations, easy alteration in membrane composition, very simple systems in terms of chemical nature and enhanced stability properties. This review contains detail about the present stature of fatty acid vesicles, comparative study of fatty acid vesicles with conventional liposomes, unique features of fatty acid vesicles (dynamicity, stability, matrix effect etc.,) and key evaluation parameters of fatty acid vesicles. Fatty acid vesicles were found to have high penetration capacity, good bio-distribution properties, increased diffusion rate and optimum drug deposition nature than other vesicular forms. They have various applications in transdermal delivery, follicular delivery and in brain targeting drug delivery systems (drugs that are unable to cross blood brain barrier due to high solubility). This review focuses on various researches conducted on fatty acid vesicles with reference to its formulation and evaluation parameters. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

脂肪酸囊泡是封闭脂质双分子层的悬浮液，由脂肪酸及其电离物质组成，这些物质被限制在一个狭窄的pH范围内。脂肪酸分子以这样一种方式定向，即它们的碳氢化合物尾部指向膜内部，羧基与水接触。最近的创新为脂肪酸囊泡的制备提供了机会，这些囊泡具有独特的特征，如pH范围的扩展、对二价阳离子的不敏感、膜组成的容易改变、化学性质非常简单的系统和增强的稳定性。本文综述了脂肪酸囊泡的现状、脂肪酸囊泡与常规脂质体的比较研究、脂肪酸囊泡的独特性(动态性、稳定性、基质效应等)以及脂肪酸囊泡的关键评价参数。脂肪酸囊泡比其他囊泡具有高渗透能力、良好的生物分布特性、更快的扩散速率和最佳的药物沉积性质。它们在透皮递送、滤泡递送和脑靶向药物递送系统(由于高溶解度而无法穿过血脑屏障的药物)中有各种应用。本文综述了脂肪酸囊泡的各种研究进展，并对其配方和评价参数进行了综述。©2020全球研究与出版基金会。版权所有。

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引用次数: 0

Anti-Inflammatory Effect of Neuracanthus Sphaerostachyus Dalz. Leaves on Experimental Colitis in Rats 球棘神经棘的抗炎作用。实验性结肠炎大鼠的叶片

Indo Global Journal of Pharmaceutical Sciences

Pub Date : 2021-01-01 DOI: 10.35652/igjps.2021.111002

Dang Dk, Patel Nj

essential ABSTRACT: Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder with unknown etiology affecting the GI tract. Neuracanthus sphaerostachyus has been traditionally used for the treatment of skin diseases, cough, and asthma in various forms orally. Lack of sufficient scientific evidence indicating the utility of this plant in the treatment of ulcerative colitis prompted us to investigate the anti-inflammatory activity of the plant on experimental colitis in rats. In-vivo pharmacological screening method for evaluation of anti-inflammatory activity of the methanolic and aqueous extract of Neuracanthus sphaerostachyus leaves at doses of 125, 250, and 500 mg/kg was assessed by TNBS-induced ulcerative colitis in Wistar rats. Colitis was induced by intra-rectal instillation of 10 mg of tri-nitro benzene sulphonic acid (TNBS) in 0.25 ml of 50% ethanol (v/v) followed by treatments with 7 d for various extracts and then animals were sacrificed to remove colon for histopathology, macroscopic scoring, and biochemical assays. The 7 d treatment with a methanolic and aqueous extract of Neuracanthus sphaerostachyus significantly improved feed intake and body weight with a decrease in macroscopical score, colonic MPO, LPO and, TNF-α. The findings from the histopathological study support the above results by its potential to protect the colonic mucosal damage. The present study exhibits anti-inflammatory potential of methanolic and aqueous extracts of Neuracanthus sphaerostachyus leaves in TNBS induced experimental colitis and it can be beneficial for patients suffering from ulcerative colitis. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.

摘要:炎症性肠病(IBD)是一种影响胃肠道的慢性特发性炎症性疾病，病因不明。球囊神经棘传统上被用于治疗各种形式的皮肤病、咳嗽和哮喘。由于缺乏足够的科学证据表明该植物在治疗溃疡性结肠炎方面的效用，因此我们研究了该植物对实验性结肠炎大鼠的抗炎活性。采用体内药理学筛选法评价125、250、500 mg/kg剂量下球囊叶甲醇和水提物的抗炎活性，采用tnbs诱导Wistar大鼠溃疡性结肠炎。以0.25 ml 50%乙醇(v/v)配制三硝基苯磺酸(TNBS)，经直肠内滴注10 mg致结肠炎后，用各种提取物处理7 d，处死动物切除结肠，进行组织病理学、宏观评分和生化检测。经甲醇和水提物处理第7 d，可显著提高采食量和体重，降低宏观评分、结肠MPO、LPO和TNF-α。组织病理学研究结果支持了上述结果，证明其具有保护结肠粘膜损伤的潜力。本研究表明，球囊神经棘叶甲醇和水提物对TNBS诱导的实验性结肠炎具有抗炎作用，对溃疡性结肠炎患者有益。©2020全球研究与出版基金会。版权所有。

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引用次数: 6