Ife Journal of Science最新文献

{"title":"Evaluation of geothermal energy resources in parts of southeastern sedimentary basin, Nigeria","authors":"I. Okiyi, S. Ibeneme, E. Obiora, S. Onyekuru, A. I. Selemo, M. Olorunfemi","doi":"10.4314/IJS.V23I1.17","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.17","url":null,"abstract":"Depth (CPD)), and estimate geothermal gradient and heat flow required for the evaluation of the geothermal resources of the study area. Results from spectral analysis showed depths to the top of the magnetic source ranging between 0.45 km and 1.90 km; centroid depths of 4 km 7.87 km and CPD of between 6.15 km and 14.19 km. The CPD were used to estimate geothermal gradients which ranged from 20.3°C/km to 50.0°C/km","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"262 3","pages":"195-211"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91470580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological synthesis of copper nanoparticles and its antimicrobial potential on selected bacteria food-borne pathogens","authors":"H. A. Aderolu, O. Aboaba, A. Aderolu, K. Abdulwahab, A. Suliman, U. Emmanuel","doi":"10.4314/IJS.V23I1.2","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.2","url":null,"abstract":"In this study, copper nanoparticle (CuNPs) was synthesized using green technology and the CuNPs was characterized with Energy Dispersive X-ray (EDX) which confirmed the presence of copper. Scanning Electron Microscopy (SEM) showed the morphology and the average size was calculated to be 2.47 ± 1 nm. The functional groups were identified by Fourier transform infrared spectroscopy (FTIR) and this revealed that OH functional group was anchored on the surface of the nanoparticles. Antimicrobial activity of the synthesizedCuNPs was investigated at varying concentrations (0.25, 0.5, 1, 2, 3, 4, 5, 6 and 7 mg/ml) dissolved in 100% dimethyl sulfoxide (DMSO). It was tested against five food borne pathogenic organisms: Salmonella typhimurium, Methicillin resistant Staphylococcus aureus  (MRSA), Enterococcus faecalis, Shigella flexneri, and Acinetobacter baumannii using the Kirby Bauer disc diffusion and agar well   method. The results showed that the antimicrobial zone of inhibition increased with an increase in concentration of the CuNPs, an  average diameter of 25 mm at 7 mg/ml, 22 mm at 5 mg/ml and an average diameter of 13 mm at 2 mg/ml of 100% DMSO.  Nanoparticles at 0.25 mg/ml and 0.5 mg/ml concentration failed to produce any clear zone across all the test organisms while only Enterococcus faecalis was sensitive with a clear zone diameter of 10 mm at 1 mg/ml CuNPs. MRSA has the least susceptibility: 9 mm clear zone diameter at 2 mg/ml and at 7 mg/ml clear zone diameter of 20 mm, relative to other tested organisms. The test organisms were not sensitive to the following conventional antibiotics: Cefuroxime, Ceftazidime, Erythromycin, Amoxicillin/Clavulanic acid and Cloxacillin, but only sensitive to Gentamicin, Ceftriaxone and Ofloxacin. MRSA on the other hand was not sensitive to all the eight antibiotics tested but susceptible to the CuNPs. The results obtained from this study indicated that copper nanoparticles can be used in the food industry to control both Gram positive and negative bacteria tested. \u0000Keywords: Synthesis, Copper nanoparticles, Antimicrobial activities, Bacteria.","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82717684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of smoking and natural preservatives on shelf – life and microbial quality of Clarias gariepinus during storage","authors":"S. Olusola","doi":"10.4314/IJS.V23I1.14","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.14","url":null,"abstract":"This study investigated the shelf – life and microbial quality of smoked Clarias gariepinus using Onion Bulb (OB), Holy Basil (HB) and Turmeric Rhizome (TR) as preservatives during 56 days storage. Sixteen C. gariepinus (1- 1.5kg) were distributed to four experimental containers: Control, TR2, OB3, and HB4 and the experiment were carried out in triplicates. Clarias gariepinus were smoked in a smoking kiln at 40o C- 60o C and 120-150 C for 6 and 18 hours respectively. Biochemical parameters, organoleptic assessment, and microbial analysis were carried out. Data were analyzed using ANOVA at P= 0.05. The result showed that the crude protein of C. gariepinus washigher in the treated groups compared to the control. Also, the result shows that the biochemical parameters, organoleptic assessment and the microbial loads in smoked C. gariepinus were reduced in the OB, HB, and TR than the control at 1 day, 28 days and 56 days storage respectively. It can be concluded that the natural plants may enhance the shelf life, consumer acceptability, and inhibit the growth of the microbial pathogen in smoked fish. \u0000Keywords: Catfish, Onion bulb, Holy basil, Microbial loads, Turmeric, Preservatives","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"1 1","pages":"145-151"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88330750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential medicinal plant remedies and their possible mechanisms against COVID-19: A review","authors":"C. Ugwah-Oguejiofor, I. Adebisi","doi":"10.4314/IJS.V23I1.16","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.16","url":null,"abstract":"Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak was first reported in Wuhan, a city in Hubei Province of China in December, 2019 and is known to be responsible for the novel coronavirus disease (COVID-19). COVID-19 was declared a pandemic in March, 2020 and since then, it has caused a number of deaths in over 200 countries around the world. Extensive researches have continued in the search of effective vaccines or drug compounds against SARS-CoV-2 and a total of 64 vaccines are currently in clinical trials with 12 currently approved for use by different regulatory bodies, depending on the country. Since the outbreak of SARS-CoV-2, many countries have utilised traditional herbal medicines alongside conventional drugs for the treatment of infected patients. In this review, traditional medicines used to prevent or treat SARS-CoV-2 infection are listed along with the plant parts as used by the traditional healers. Additionally, the possible mechanisms responsible for this preventive or therapeutic outcome are also identified and listed. Our literature search was conducted using Google Scholar, PubMed, Scopus and WHO website. Unpublished reports such asdissertations and theses are not included. Plant parts including roots, leaves, flowers, seeds and so on have been used in the treatment of COVID-19. These traditional medicinal herbs may exert their anti-COVID-19 activity by direct inhibition of the virus replication or entry. Some may act by blocking the ACE-2 receptor, SARS-CoV helicase, Type II Transmembrane Serine Protease (TMPRSS2) and which are required by SARS-CoV-2 in order to infect human cells. Others act by inhibiting the SARSCoV-2 life-cycle related proteins, namely chymotrypsin-like cysteine protease (3CL-pro) and Papain-like protease (PL-pro). Medicinal plants are promising alternative medicines for the treatment or prevention of SARS-CoV-2 infection. Further researches, are needed to decipher their active components and structures which may suggest clues for the development of drugs against this novel coronavirus. \u0000Keywords: Severe Acute Respiratory Syndrome (SARS-CoV-2), COVID-19, medicinal plants, plant parts, mechanism of action, pandemic,","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81215175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization and antibacterial activity of mixed ligand complexes of Nicotinamide and 2,2′-Bipyridine","authors":"O. Akinyele, E. Fakola, R. George, L. M. Durosinmi","doi":"10.4314/IJS.V23I1.18","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.18","url":null,"abstract":"solubility studies, magnetic susceptibility, percentage metal analysis, UV-Vis spectroscopy, IR spectroscopy and conductivity measurements. The observed metal analysis were in agreement with the theoretical values. The magnetic susceptibility data showed that all the complexes were paramagnetic with values ranging from 1.50 to 4.92 B.M, except [Zn(NA)(Bipy)Cl H O] which is diamagnetic. The conductivity values of 96.20, 123.20 and 2 2 -1 2 -1 130.80 Ω cm mol Cu(II), Co(II) and Mn(II) complexes respectively reveal their 1:1 electrolytic nature, while","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"61 1","pages":"213-222"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73246496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoavailablility and fractionation of cadmium and lead in vegetable farm soils in Ilorin, north-central, Nigeria","authors":"P. O. Ben-Uwabor, G. Olawepo, Clement O Ogunkunle, O. Fatoba","doi":"10.4314/IJS.V23I1.4","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.4","url":null,"abstract":"Heavy metal dynamics, bioavailability and fractionation are of great importance to measure soil toxicity, in soil. However, reports showed that not much has been done to evaluate these parameters in vegetable farm soils in Ilorin metropolis. These parameters aid in assessing and extent of heavy metal viability in soil. Therefore, soils were collected from major vegetable farms in Ilorin metropolis, sorted, Thus, this study investigated the bioavailable Cd and Pb and their fractionation in vegetable farm soils in Ilorin metropolis. These experiments were conducted by , sequential extraction and Atomic Absorption Spectrophotometry, alongside analysis of some key soil properties. The results showed that the soil pH ranged from 6.62±0.04 to 7.18±0.03, organic matter 2.05 target heavy metals in the sampling areas were potentially bioavailable with phytoavailable concentration ranges of . The target heavy metals showed a high viability of the soluble and exchangeable form in most soils and in both seasons which would greatly contribute to their availability to plant uptake and soil toxicity. There is also a threat of oxidization of the potentially available Cd and Pb in other forms due to pH ranges of most of the studied soils. Therefore, vegetable farm soils in Ilorin metropolis are polluted with Cd and Pb and may have high risk of causing human health problems when vegetables grown on the soils are consumed; which calls for remediation of most of the soils. , 031 Ife Journal of Science vol. 23, no. 1 (2021) INTRODUCTION Heavy metals abound naturally in soil environment, as a result of processes of weathering of parent materials at levels that are regarded as trace and rarely toxic substance, and also from human anthropogenic activities (Herawati et al, 2010). Of the heavy metals that abound, cadmium (Cd) and lead (Pb) are common and widely studied contaminants because of their spectrum of use in production of lead-acid batteries, lead-based paints, automobiles, oil refineries, and antiknock in petrol (Ying et al., 2013). In terms of environmental concentration, Pb is the heavy metal closest to the level in which toxic signs manifest than any other substance (Iwegbue et al., 2013). Heavy metal distribution, dynamics and transport in soil depend significantly on their chemical forms (Debnárová and Doleţa, 2010). Once in the soil, heavy metals are adsorbed by initial fast reactions (minutes, hours), followed by slow adsorption reactions (days, years) and are, therefore, redistributed into different chemical forms with varying bioavailability, mobility and toxicity (Deng et al., 2012). Reports had shown that not all the heavy metals in the soil are readily available to plant but may become available under some environmental influences or changes such as pH, redox potential, cation exchange capacity, organic matter content and moisture content of the soil (Yadawe, 2011). The fraction of a total heavy metal content that is available for plant uptake in the","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"12 1","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80897733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption of methylene blue on corncob charcoal: Thermodynamic studies","authors":"A. A. Fodeke, O. J. Ayejuyone","doi":"10.4314/IJS.V23I1.13","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.13","url":null,"abstract":"131 Ife Journal of Science vol. 23, no. 1 (2021) INTRODUCTION Dyes have found great use in several human activities such as textile, paper, paint, cosmetics, additives in food and many other uses. A large amount of these dyes find their way into water bodies where they cause harm for aquatic life and make the water unfit for human consumption. In the search of a cheap and sustainable means of removing dye pollutants, several researchers have embarked on experiments aimed at finding methods, optimum conditions and materials that can be used for efficient dye removal (Malik et al., 2007; Suteu et al., 2011; Garg et al., 2004; Adegoke et al., 2015; Amodu et al., 2015). Removal of dyes and metallic ions from wastewater has stimulated significant interest in the use of synthetic polymers. Materials such as polyphynylamine (Amodu et al . , 2015), p o l y ( c y c l o t r i p h o s p h a z e n e c o 4 , 4 sulfonyldiphenol) nano tubes (Ayad et al., 2012; Chen et al., 2014) and carbon based materials from agricultural wastes (banana peel, cassava peel, rice bran, periwinkle shell, corncob and palm kernel husk) have been employed in water purification (Kumur et al., 2008; Bello et al., 2008; Rajeshwarisivaraj et al., 2001). While much of the work in the past had been dedicated to finding the most suitable kinetic and adsorption model for fitting data from adsorption experiments (with the hope of ascertaining the mechanism of adsorption), the suitability of the equilibrium adsorption model had often been predicated on the goodness of the fit of a given adsorption isotherm model used in fitting the experimental data. Little data is available on the systematic studies of the relationship between fitting model and the thermodynamics of adsorption of adsorbates on adsorbents. Where such studies were carried out, adsorption properties of the adsorbates and adsorbents are often not related quantitatively or semi-quantitatively to the thermodynamic quantities obtained. To remove ambiguity that may arise from the shortcomings described above, we undertake to: (i) determine how adsorption of MB on corncob charcoal are affected by pH at the point of zero charge of the adsorbent and also above and below it; (ii) estimate the effect which acid treatment of corncob charcoal had on its adsorption properties compared to the untreated corncob; (iii) https://dx.doi.org/10.4314/ijs.v23i1.13","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"20 1","pages":"131-144"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87042631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of otitis media in children attending a Primary Health Care Center in Samaru, Zaria, Nigeria","authors":"H. Atta, F. Umar","doi":"10.4314/IJS.V23I1.12","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.12","url":null,"abstract":"Otitis media is an inflammatory disease of the mucosal lining of the middle ear. It occurs more frequently in children due to the shorter and more horizontal eustachian tube in their ears. The focus of this study is determining the prevalence of otitis media in children aged 6 months – 10 years attending a primary health care facility in Samaru, Zaria, Nigeria. Fifty swabs from ear discharge and imparted wax were obtained from the study subjects regardless of whether they were presenting with symptoms of otitis media or not. Information on certain symptoms, as well as demographic and risk factors was obtained through the use of questionnaires. A prevalence of 54% of otitis media was obtained in this study. The following bacterial species were isolated: Pseudomonas aeruginosa (25.7%), Escherichia coli (25.7%), Klebsiella pneumoniae (14.3%), Staphylococcus aureus (14.3%), Proteus mirabilis (8.6%), Coagulase negative Staphylococci (8.6%) and Proteus vulgaris (3.7%). The infection was observed to be higher in children in the age range, six months to two years. Risk factors such as the use of cotton buds in cleaning the ear, posture of the child during breast-feeding and not being exclusively breast-fed were shown to be very prominent among the children studied. Antibiotic susceptibility tests revealed that among the Gram negative bacteria isolated, Pseudomonas aeruginosa and Klebsiella pneumoniae were resistant to more than two antibiotics. Coagulase negative Staphylococcus was resistant to all the antibiotics except Ceftriaxone, Streptomycin and Cefuroxime. On the other hand, Staphylococcus aureus was susceptible to all the antibiotics tested with the exception of Cefuroxime, Ceftriaxone and Ampiclox. Therefore, it is recommended that antibiotic susceptibility testing be conducted before treatment of otitis media in children. The importance of exclusive breast-feeding and good personal hygiene should be emphasized to nursing mothers. \u0000Key words: Otitis media, Children, Bacteria, Antibiotics, Zaria","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74231441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of morpho-variability between bruchid tolerant AND SUSCEPTIBLE cowpea (Vigna unguiculata L. Walp.) accessions","authors":"O. Amusa, L. Ogunkanmi","doi":"10.4314/IJS.V23I1.10","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.10","url":null,"abstract":"Cowpea bruchid is a major constraint to cowpea production. Easy identification of resistant/tolerant accessions to bruchid infestation has been a major challenge in bruchid resistant breeding programmes. Hence, the study was aimed to evaluate variations in some morphological characters between some bruchid resistant/tolerant and susceptible cowpea accessions, correlating them with their bruchid tolerance status in the hope of identifying a pointer character(s) that can facilitate easy identification of bruchid tolerant among cowpea germplasm. Sixty accessions were collected and evaluated for bruchid tolerance. Accessions were then grouped into bruchid susceptible and bruchid tolerant. These accessions were planted in Randomized Complete Block Design with ten replicates. Morphological differences between groups were evaluated accordingly. Of the sixty accessions evaluated, fifty-two were susceptible while eight were bruchid tolerant. No qualitative differences were observed between bruchid susceptible and tolerant groups, however significant differences were observed in quantitative characters which include terminal leaflet length, terminal leaflet/width ratio, leaf petiole length, terminal leaflet petiole length (TLPL), leaf petiole length, pod length (PDL), pod width, total number of pods per plant, seed length (SDL), seed width (SDW), seed thickness (SDTK) and 100 seed weight (100SDW). Bruchid tolerance was significantly positively correlated with seed characters which include, SDL (r = 0.798, p < 0.01); SDW (r = 0.798, p < 0.01); SDTK (r = 0.758, p < 0.01); 100SDW (0.830, p < 0.01) and significantly negatively correlated with TLPL and PDL (p < 0.05). These characters can provide easy identification of bruchid tolerant among cowpea germplasm, hence requires further investigations.","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"17 1","pages":"105-114"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91216821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preservation of antioxidant defense system by Morin in bicalutamide-induced rat testicular toxicity","authors":"E. Olayinka, A. Ore, O. Olotu, V. U. Ogbuji, O. A. Adeyemo, Olaniyi Solomon Ola","doi":"10.4314/IJS.V23I1.11","DOIUrl":"https://doi.org/10.4314/IJS.V23I1.11","url":null,"abstract":"Bicalutamide (BCT) is a potent anti-androgen chemotherapeutic drug indicated for prostate cancer. However, BCT is known to cause oxidative stress and impairment of male reproductive function. Whereas Morin (MOR), a flavonoid has been found to be a potent antioxidant, with free radical scavenging capacity. This study investigated the protective effect of MOR on BCT-induced testicular toxicity in Wistar rats. Twenty-four male albino rats were randomized into four groups (n=6/group). Group I which served as control received distilled water. Group II, received 3 mg/kg body weight (bwt) BCT orally (per os); group III received 3 mg/kg/day BCT p.o. plus 100 mg/kg/d MOR p.o. and group IV received 100 mg/kg/d MOR p.o. All treatments lasted for 14 days, thereafter, animals were sacrificed and epididymis and testis were collected for sperm and biochemical analyses. The result revealed that BCT treatment caused a significant increase in abnormal sperm morphology. Sperm production, sperm count, motility and viability were significantly reduced when compared with control (p<0.05). Similarly, testicular superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx),glutathione S-transferase (GST) and acid phosphatase (ACP) activities, as well as ascorbic acid and GSH levels were significantly reduced in the BCT- treated animals when compared to control (p<0.05). Conversely, testicular alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) and lactate dehydrogenese (LDH) activities as well as malondialdehyde (MDA) levels of BCT-treated animals  increased significantly relative to control (p<0.05). However, co-treatment with Morin ameliorated BCT-induced alterations in sperm parameters, ascorbic acid, GSH and MDA levels, as well as LDH, SOD, CAT, GST, GPX, ACP, ALP and GGT activities. Data obtained from this study suggest that Morin protected against altered sperm parameters and testicular oxidative stress caused by BCT. \u0000Keywords: Bicalutamide, Anti-androgen, Testis, Oxidative stress, Morin, Antioxidant, Rat","PeriodicalId":13487,"journal":{"name":"Ife Journal of Science","volume":"55 1","pages":"115-122"},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76853933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}