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Investigating Slit-Collimator-Produced Carbon Ion Minibeams with High-Resolution CMOS Sensors 用高分辨率CMOS传感器研究狭缝准直器产生的碳离子微束
Q3 Physics and Astronomy Pub Date : 2023-06-06 DOI: 10.3390/instruments7020018
L. Volz, C. Reidel, M. Durante, Y. Prezado, C. Schuy, U. Weber, C. Graeff
Particle minibeam therapy has demonstrated the potential for better healthy tissue sparing due to spatial fractionation of the delivered dose. Especially for heavy ions, the spatial fractionation could enhance the already favorable differential biological effectiveness at the target and the entrance region. Moreover, spatial fractionation could even be a viable option for bringing ions heavier than carbon back into patient application. To understand the effect of minibeam therapy, however, requires careful conduction of pre-clinical experiments, for which precise knowledge of the minibeam characteristics is crucial. This work introduces the use of high-spatial-resolution CMOS sensors to characterize collimator-produced carbon ion minibeams in terms of lateral fluence distribution, secondary fragments, track-averaged linear energy transfer distribution, and collimator alignment. Additional simulations were performed to further analyze the parameter space of the carbon ion minibeams in terms of beam characteristics, collimator positioning, and collimator manufacturing accuracy. Finally, a new concept for reducing the neutron dose to the patient by means of an additional neutron shield added to the collimator setup is proposed and validated in simulation. The carbon ion minibeam collimator characterized in this work is used in ongoing pre-clinical experiments on heavy ion minibeam therapy at the GSI.
粒子微束治疗已经证明,由于所给剂量的空间分割,有可能更好地保留健康组织。特别是对于重离子,空间分选可以增强靶区和入口区本已良好的差异生物效应。此外,空间分馏甚至可能是将比碳重的离子带回患者应用的可行选择。然而,要了解微束治疗的效果,需要仔细进行临床前实验,因此精确了解微束特性至关重要。这项工作介绍了使用高空间分辨率CMOS传感器来表征准直器产生的碳离子微束的横向通量分布、二次碎片、轨迹平均线性能量传递分布和准直器对准。通过仿真进一步分析了碳离子微光束在光束特性、准直器定位和准直器制造精度等方面的参数空间。最后,提出了一种通过在准直器装置中增加一个额外的中子屏蔽来减少病人中子剂量的新概念,并在仿真中进行了验证。在这项工作中表征的碳离子微束准直器用于GSI正在进行的重离子微束治疗的临床前实验。
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引用次数: 1
Geant4 Simulation of Muon Absorption in Concrete Layers Geant4模拟Muon在混凝土层中的吸收
Q3 Physics and Astronomy Pub Date : 2023-05-31 DOI: 10.3390/instruments7020017
D. Joffe, Christian Pérez
Muography requires a detailed understanding of the absorption of muons in the material situated between the muon source and the detector. A large-statistics (>3 billion event) Geant4 simulation was run to simulate the absorption of muons in different thicknesses of concrete layers and to determine the effect of the material on the energies of muons that were not absorbed. The Geant4 simulation included a simple detector placed directly behind the absorbing material. A Geant4 simulation was also run for the same detector for alpha sources with no absorbing material and the results of this simulation were compared to the signals from the physical detector built in the laboratory and measured using standard alpha sources. The large-statistics simulations using muons of different energies were compared to the predictions of muon absorption from existing literature. The results of the simulations were in good agreement with both the measured signals from the laboratory as well as the predictions from the literature and the general method is found to be well-suited for studies used for muography involving material layers of uniform thickness.
Muography需要详细了解介子在介子源和探测器之间的物质中的吸收。采用大统计量(bbb30亿事件)的Geant4模拟,模拟了不同厚度混凝土层对μ子的吸收,并确定了材料对未被吸收μ子能量的影响。Geant4模拟包括一个简单的探测器,直接放置在吸收材料的后面。在没有吸收材料的情况下,对相同的α源探测器进行了Geant4模拟,并将模拟结果与实验室中构建的物理探测器和使用标准α源测量的信号进行了比较。利用不同能量的μ子进行的大统计模拟与现有文献中对μ子吸收的预测进行了比较。模拟的结果与实验室的测量信号以及文献的预测都很好地一致,并且发现一般方法非常适合用于涉及均匀厚度的材料层的记录研究。
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引用次数: 0
Two-Dimensional Thomson Scattering in Laser-Produced Plasmas 激光等离子体中的二维汤姆逊散射
Q3 Physics and Astronomy Pub Date : 2023-05-13 DOI: 10.3390/instruments7030025
Haiping Zhang, J. Pilgram, Carmen G. Constantin, L. Rovige, P. Heuer, S. Ghazaryan, M. Kaloyan, R. Dorst, Derek Schaeffer, Christoph Niemann
We present two-dimensional (2D) optical Thomson scattering measurements of electron density and temperature in laser-produced plasmas. The novel instrument directly measures ne(x,y) and Te(x,y) in two dimensions over large spatial regions (cm2) with sub-mm spatial resolution, by automatically translating the scattering volume while the plasma is produced repeatedly by irradiating a solid target with a high-repetition-rate laser beam (10 J, ∼1012 W/cm2, 1 Hz). In this paper, we describe the design and motorized auto-alignment of the instrument and the computerized algorithm that autonomously fits the spectral distribution function to the tens-of-thousands of measured scattering spectra, and captures the transition from the collective to the non-collective regime with distance from the target. As an example, we present the first 2D scattering measurements in laser-driven shock waves in ambient nitrogen gas at a pressure of 0.13 mbar.
我们提出二维(2D)光学汤姆逊散射测量电子密度和温度在激光产生的等离子体。该新型仪器在大空间区域(cm2)上以亚毫米的空间分辨率直接测量二维ne(x,y)和Te(x,y),通过自动转换散射体积,同时用高重复率激光束(10 J, ~ 1012 W/cm2, 1 Hz)照射固体目标反复产生等离子体。在本文中,我们描述了仪器的设计和机动自动对准,以及计算机算法,该算法自动拟合光谱分布函数到数万个测量的散射光谱,并捕获从集体到非集体状态随距离目标的转变。作为一个例子,我们提出了在0.13毫巴压力的环境氮气中激光驱动激波的第一个二维散射测量。
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引用次数: 0
Quenching Circuit Discriminator Architecture Impact on a Sub-10 ps FWHM Single-Photon Timing Resolution SPAD 猝灭电路鉴别器结构对低于10ps FWHM单光子时序分辨率SPAD的影响
Q3 Physics and Astronomy Pub Date : 2023-04-09 DOI: 10.3390/instruments7020016
F. Nolet, V. Gauthier, S. Parent, F. Vachon, N. Roy, Nicolas St-Jean, S. Charlebois, J. Pratte
In the field of radiation instrumentation, there is a desire to reach a sub-10 ps FWHM timing resolution for applications such as time-of-flight positron emission tomography, time-of-flight positron computed tomography and time-resolved calorimetry. One of the key parts of the detection chain for these applications is a single-photon detector and, in recent years, the first single-photon avalanche diode (SPAD) with a sub-10 ps timing resolution was presented. To reach such a timing resolution, the SPAD was read out by an operational amplifier operated in open-loop as a comparator. This paper presents a comparison between comparators and inverters to determine which type of leading-edge discriminator can obtain the best single-photon timing resolution. Six different quenching circuits (QCs) implemented in TSMC 65 nm are tested with SPADs of the same architecture and in the same operation conditions. This allows us to compare experimental results between the different QCs. This paper also presents a method to measure the SPAD signal slope, the SPAD excess voltage variation and simulations to determine the added jitter of different leading-edge discriminators. For some discriminator architectures, a cascode transistor was required to increase the maximum excess voltage of the QC. This paper also presents the impact on the single-photon timing resolution of adding a cascode transistor for a comparator or an inverter-based discriminator. This paper reports a 6.3 ps FWHM SPTR for a SPAD read out by a low-threshold comparator and a 6.8 ps FWHM SPTR for an optimized 1 V inverter using a cascode transistor for a higher excess voltage.
在辐射仪器领域,人们希望达到低于10ps的FWHM定时分辨率,用于诸如飞行时间正电子发射断层扫描、飞行时间正电子计算机断层扫描和时间分辨量热法的应用。这些应用的检测链的关键部分之一是单光子探测器,近年来,提出了第一个具有低于10ps时序分辨率的单光子雪崩二极管(SPAD)。为了达到这样的定时分辨率,SPAD由作为比较器的开环运算放大器读出。本文对比较器和反相器进行了比较,以确定哪种类型的前沿鉴别器可以获得最佳的单光子定时分辨率。用相同结构和相同操作条件的SPAD测试了在台积电65nm中实现的六种不同的猝灭电路(QC)。这使我们能够比较不同QC之间的实验结果。本文还提出了一种测量SPAD信号斜率的方法、SPAD过电压变化以及确定不同前沿鉴别器的附加抖动的模拟。对于一些鉴别器架构,需要级联晶体管来增加QC的最大过电压。本文还介绍了为比较器或基于反相器的鉴别器添加级联晶体管对单光子定时分辨率的影响。本文报道了由低阈值比较器读出的SPAD的6.3ps FWHM SPTR和使用级联晶体管的优化1V逆变器的6.8ps FWHM SPTR,以获得更高的过电压。
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引用次数: 0
Design and Manufacture of a Test Device for Radiosynthesizer Vacuum Pumps 放射性合成器真空泵试验装置的设计与制造
Q3 Physics and Astronomy Pub Date : 2023-04-06 DOI: 10.3390/instruments7020015
Victor Amador Diaz, Scott Snyder, A. Vāvere
Vacuum pump wear is the most prevalent failure mode of the IBA Synthera® automated radiochemistry system. Rebuilding or replacing the pump causes equipment downtime and increases the radiation exposure of the service personnel. We built a dedicated test device to assess new or rebuilt pumps prior to installation, thus reducing downtime and radiation exposure during repairs. The Testbed incorporates a microprocessor that actuates the pump, valves, and pressure sensor; communicates with the user through lights, buttons, and an alphanumeric screen; and outputs test results to a laptop. The Testbed increases productivity and safety in the radiochemistry laboratory.
真空泵磨损是IBA Synthera®自动化放射化学系统最常见的故障模式。重建或更换泵会导致设备停机,并增加服务人员的辐射暴露。我们建造了一个专用的测试设备,用于在安装前评估新的或重建的泵,从而减少维修期间的停机时间和辐射暴露。试验台包含一个微处理器,用于启动泵、阀门和压力传感器;通过灯、按钮和字母数字屏幕与用户进行通信;并将测试结果输出到笔记本电脑。试验台提高了放射化学实验室的生产力和安全性。
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引用次数: 0
Fast Timing Detectors and Applications in Cosmic Ray Physics and Medical Science 快速定时探测器及其在宇宙射线物理和医学中的应用
Q3 Physics and Astronomy Pub Date : 2023-03-23 DOI: 10.3390/instruments7020014
Christophe Royon, William d’Assignies D., Florian Gautier, Tommaso Isidori, Nicola Minafra, Alexander Novikov
We use fast silicon detectors and the fast sampling method originally developed for high energy physics for two applications: cosmic ray measurements in collaboration with NASA and dose measurements during flash beam cancer treatment. The cosmic ray measurement will benefit from the fast sampling method to measure the Bragg peak where the particle stops in the silicon detector and the dose measurement is performed by counting the number of particles that enter the detector.
我们使用快速硅探测器和最初为高能物理开发的快速采样方法,用于两个应用:与美国宇航局合作的宇宙射线测量和闪光束癌症治疗期间的剂量测量。宇宙射线测量将受益于快速采样方法来测量粒子在硅探测器中停止的布拉格峰,并通过计数进入探测器的粒子数量来进行剂量测量。
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引用次数: 0
Cosmic-Ray Tomography for Border Security 用于边境安全的宇宙射线层析成像
Q3 Physics and Astronomy Pub Date : 2023-03-20 DOI: 10.3390/instruments7010013
Sarah Barnes, A. Georgadze, A. Giammanco, M. Kiisk, V. Kudryavtsev, Maxime Lagrange, Olin Lyod Pinto
A key task for customs workers is the interception of hazardous, illegal and counterfeit items in order to protect the health and safety of citizens. However, it is estimated that only a small fraction of cargo is inspected and an even smaller fraction of trafficked goods are detected. Today, the most widely used technology for scanning vehicles, ranging from vans and trucks to railcars, is γ ray and X-ray radiography. New technologies are required to overcome current technological shortcomings, such as the inability to detect the target material composition, the usage of harmful ionising radiation sources and the resultant low throughput. Cosmic ray tomography (CRT) is a promising technology for cargo screening. Cosmic ray muons have average energies of around 10,000 times larger than a typical X-ray and therefore can penetrate relatively large and dense materials. By analysing muon scattering, it is possible to identify materials hidden inside shielding that is too thick or deep for other imaging methods. CRT is also completely passive, exploiting naturally occurring secondary cosmic radiation, and is therefore safe for humans and animals. Contrary to conventional X-ray- or γ-ray-based imaging techniques, CRT also allows material differentiation and anomaly localisation within the cargo or vehicle through the provision of 3D images. This article reviews the current state-of-the-art technology in CRT, critically assessing the strengths and weaknesses of the method, and suggesting further directions for development.
海关工作人员的一项关键任务是截获危险、非法和假冒物品,以保护公民的健康和安全。然而,据估计,只有一小部分货物被检查,而被发现的走私货物则更少。今天,从货车、卡车到有轨电车,最广泛使用的扫描车辆技术是γ射线和x射线照相技术。需要新技术来克服目前的技术缺点,例如无法检测目标材料成分,使用有害的电离辐射源以及由此产生的低吞吐量。宇宙射线断层扫描(CRT)是一种很有前途的货物扫描技术。宇宙射线μ介子的平均能量大约是典型x射线的1万倍,因此可以穿透相对较大和致密的物质。通过分析μ子散射,有可能识别隐藏在屏蔽内的物质,这些物质对于其他成像方法来说太厚或太深。CRT也是完全被动的,利用自然发生的二次宇宙辐射,因此对人类和动物是安全的。与传统的基于x射线或γ射线的成像技术相反,CRT还可以通过提供3D图像来区分货物或车辆内的物质和异常定位。本文回顾了当前CRT的最新技术,批判性地评估了该方法的优缺点,并提出了进一步的发展方向。
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引用次数: 7
Upgrade of Thomson Scattering Diagnostic on HL-2A HL-2A的汤姆森散射诊断升级
Q3 Physics and Astronomy Pub Date : 2023-03-06 DOI: 10.3390/instruments7010012
Wenping Guo, Yuan Huang, Chunhua Liu, Zhen Feng, Zhipei Hou, Wenyan Zhai, H. Funaba, I. Yamada, Yonggao Li, Zhongbing Shi
The Thomson scattering diagnostic of the HL-2A tokamak device was upgraded to improve its multi-point diagnostic capability, including new collection optics, fibers bundles, and data analysis code. The small old collection lens was replaced by a six-piece lens with a Cooke optical design. The aperture of its first standard sphere face is 310.125 mm, which successfully increases the amount of collected scattering light by about three times. The new collection optic module allows for up to twenty-six spatial points. A kind of Y-type fiber bundle has also been used to ensure that the fiber end-face matches the image of the laser beam exactly. Additionally, the new data analysis code can provide preview results in seconds. Finally, the multi-point Te diagnostic ability has been significantly improved.
对HL-2A托卡马克装置的汤姆森散射诊断进行了升级,以提高其多点诊断能力,包括新的收集光学器件、光纤束和数据分析代码。小旧的集合镜头被库克光学设计的六片镜头所取代。它的第一个标准球面孔径为310.125 mm,成功地将散射光的收集量增加了约3倍。新的收集光学模块允许多达26个空间点。为了保证光纤端面与激光束图像的精确匹配,还采用了一种y型光纤束。此外,新的数据分析代码可以在几秒钟内提供预览结果。最后,多点诊断能力明显提高。
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引用次数: 0
Commissioning Results of the New Compact ECR Ion Source for Electrostatic Storage Ring at KACST KACST新型紧凑型ECR静电存储环离子源调试结果
Q3 Physics and Astronomy Pub Date : 2023-02-23 DOI: 10.3390/instruments7010011
S. Alshammari, A. Jabr, Saad Jaddua, Abdulhakim Alabadusalam
A compact microwave ECR ion source with low operating power was tested and commissioned for the ion injector line in the multipurpose low-energy ELASR storage ring facility at King Abdulaziz City for Science and Technology (KACST) in Riyadh. The compact ECR ion source can deliver singly charged ions with an energy of up to 50 keV and a beam current of up to 50 μA or up to 500 µA with a larger extraction aperture. The plasma in the ECR chamber is driven by a simple transmitter antenna, making the overall size of the ion source only 6 cm in diameter, which is relatively small when compared with other ECR systems. Additionally, the source operates without a high-voltage platform, which significantly reduces the overall footprint and simplifies the system operation. In this paper, the mechanical design and modeling of the ECR ion source are introduced, and the layout of the first part of the beam line is presented along with the numerical simulation results. In addition, the experimental results obtained for the first generated ion beam and commissioning of the ECR ion source are introduced and discussed.
在利雅得阿卜杜勒阿齐兹国王科技城(KACST)的多用途低能ELASR存储环设施中,对一种低工作功率的紧凑型微波ECR离子源进行了测试,并在离子注入线上进行了调试。紧凑的ECR离子源可以输送能量高达50 keV的单电荷离子,光束电流高达50 μA或500 μA,提取孔径更大。ECR腔室中的等离子体由一个简单的发射天线驱动,使得离子源的总直径只有6厘米,与其他ECR系统相比,这是相对较小的。此外,该电源无需高压平台即可运行,这大大减少了总体占地面积,简化了系统操作。本文介绍了ECR离子源的力学设计和建模,并结合数值模拟结果给出了第一部分束流线的布置。此外,还介绍和讨论了ECR离子源首次产生离子束的实验结果和调试情况。
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引用次数: 0
RF Design and Measurements of a C-Band Prototype Structure for an Ultra-High Dose-Rate Medical Linac 超高剂量率医用直线加速器C波段原型结构的射频设计与测量
Q3 Physics and Astronomy Pub Date : 2023-02-22 DOI: 10.3390/instruments7010010
L. Giuliano, F. Bosco, M. Carillo, G. Felici, L. Ficcadenti, A. Mostacci, M. Migliorati, L. Palumbo, B. Spataro, L. Faillace
In this paper, we illustrate the RF design and measurements of a C-band prototype structure for an Ultra High Dose Rate medical linac. (1) Background: FLASH Radiotherapy (RT) is a revolutionary new technique for cancer cure. It releases ultra-high radiation dose rates (above 100 Gy/s) in microsecond short pulses. In order to obtain a high dose in a very short time, accelerators with high-intensity currents (the order of 100 mA peak currents) have to be developed. In this contest, Sapienza University, in collaboration with SIT-Sordina IORT Technology spa, is developing a new C-band linac to achieve the FLASH regime. (2) Methods: We performed the RF electromagnetic design of the prototype of the C band linac using CST STUDIO Suite Code and the RF low power RF test at Sapienza University of Rome. The measurements of the field in the cavity have been done with the bead-pull technique. (3) Results: This device is a nine-cell structure operating on the π/2 mode at 5.712 GHz (C-band). We report and discuss the test measurement results on a full-scale copper prototype, showing good agreement with CST RF simulations. A tuning procedure has been implemented in order to ensure proper operating frequency and to reach a field profile flatness of the order of a few percent. (4) Conclusions: The prototype of a C-band linac for FLASH applications was successfully tested with low RF power at Sapienza University. The fabrication and ad hoc tuning procedures have been optimized and discussed in the paper.
在本文中,我们介绍了超高剂量率医用直线加速器C波段原型结构的射频设计和测量。(1) 背景:FLASH放射治疗(RT)是治疗癌症的革命性新技术。它在微秒短脉冲中释放超高辐射剂量率(超过100 Gy/s)。为了在很短的时间内获得高剂量,必须开发具有高强度电流(峰值电流为100mA的量级)的加速器。在这场比赛中,萨皮恩扎大学与SIT Sordina IORT Technology spa合作,正在开发一种新的C波段直线加速器,以实现FLASH方案。(2) 方法:我们使用CST STUDIO Suite Code对C波段直线加速器原型进行了射频电磁设计,并在罗马萨皮恩扎大学进行了射频低功率射频测试。已经用拉珠技术对空腔中的场进行了测量。(3) 结果:该器件是一个在5.712GHz(C波段)π/2模式下工作的九单元结构。我们报告并讨论了全尺寸铜原型的测试测量结果,显示出与CST RF模拟的良好一致性。为了确保适当的工作频率并达到百分之几量级的场轮廓平坦度,已经实施了调谐程序。(4) 结论:用于FLASH应用的C波段直线加速器原型在萨皮恩扎大学以低RF功率成功测试。本文对制造和特殊调谐程序进行了优化和讨论。
{"title":"RF Design and Measurements of a C-Band Prototype Structure for an Ultra-High Dose-Rate Medical Linac","authors":"L. Giuliano, F. Bosco, M. Carillo, G. Felici, L. Ficcadenti, A. Mostacci, M. Migliorati, L. Palumbo, B. Spataro, L. Faillace","doi":"10.3390/instruments7010010","DOIUrl":"https://doi.org/10.3390/instruments7010010","url":null,"abstract":"In this paper, we illustrate the RF design and measurements of a C-band prototype structure for an Ultra High Dose Rate medical linac. (1) Background: FLASH Radiotherapy (RT) is a revolutionary new technique for cancer cure. It releases ultra-high radiation dose rates (above 100 Gy/s) in microsecond short pulses. In order to obtain a high dose in a very short time, accelerators with high-intensity currents (the order of 100 mA peak currents) have to be developed. In this contest, Sapienza University, in collaboration with SIT-Sordina IORT Technology spa, is developing a new C-band linac to achieve the FLASH regime. (2) Methods: We performed the RF electromagnetic design of the prototype of the C band linac using CST STUDIO Suite Code and the RF low power RF test at Sapienza University of Rome. The measurements of the field in the cavity have been done with the bead-pull technique. (3) Results: This device is a nine-cell structure operating on the π/2 mode at 5.712 GHz (C-band). We report and discuss the test measurement results on a full-scale copper prototype, showing good agreement with CST RF simulations. A tuning procedure has been implemented in order to ensure proper operating frequency and to reach a field profile flatness of the order of a few percent. (4) Conclusions: The prototype of a C-band linac for FLASH applications was successfully tested with low RF power at Sapienza University. The fabrication and ad hoc tuning procedures have been optimized and discussed in the paper.","PeriodicalId":13582,"journal":{"name":"Instruments","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42268629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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