Inorganic Chemistry Communications最新文献_第6页

A new metallocomplex with antitumor activity fabricated from ditopic bis(1-(pyridin-2-yl)-methylidene)carbazide and Cd(NO3)2

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-23 DOI: 10.1016/j.inoche.2025.114180

Ghodrat Mahmoudi , Burcu Saygıdeğer , Aycan Sezan , Yasemin Saygideger , Antonio Frontera , Damir A. Safin

This study reports the structural analysis and antitumor properties of a new dinuclear heteroleptic discrete Cd(II) complex, [Cd₂(H₂L)(NO₃)₃(H₂O)₃]NO₃ (1), synthesized through the reaction of Cd(NO₃)₂·4H₂O with bis(1-(pyridin-2-yl)-methylidene)carbazide (H₂L). The asymmetric unit of 1 comprises two dinuclear heteroleptic [Cd₂(H₂L)(NO₃)₃(H₂O)₃]⁺ cations and two NO₃⁻ anions. Each [Cd₂(H₂L)(NO₃)₃(H₂O)₃]⁺ cation features two distinct coordination polyhedra: [Cd(N^N′^O)(NO₃)₂(H₂O)] and [Cd(N^N′^O)(NO₃)(H₂O)₂]⁺ (N^N′^O = one chelating pendant arm of H₂L). Notably, the coordinated NO₃⁻ anions exhibit either bidentate or anisobidentate coordination modes. The crystal structure of 1 is stabilized by a range of intermolecular interactions, including O–H⋯O, N–H⋯O, and π⋯π interactions. Additionally, antiparallel NO⋯NO interactions involving the coordinated nitrato ligands were identified and confirmed using NCIplot and QTAIM computational tools.

The cytotoxic and antiproliferative effects of 1, as well as its inhibition of colonization and metastasis in the MCF-7, Huh7, HCT-116, and A549 cell lines, were investigated. While H₂L exhibited no cytotoxicity, complex 1 demonstrated cell-killing activity, with IC₅₀ values of 17.05 µM for MCF-7, 14.02 µM for Huh7, and 27.27 µM for HCT-116 cells. In addition, 1 increased the expression of the DNA damage response protein p21 in HCT-116 cells. A549 cells showed lower sensitivity to 1 compared to the other cell lines examined in this study.

{"title":"A new metallocomplex with antitumor activity fabricated from ditopic bis(1-(pyridin-2-yl)-methylidene)carbazide and Cd(NO3)2","authors":"Ghodrat Mahmoudi , Burcu Saygıdeğer , Aycan Sezan , Yasemin Saygideger , Antonio Frontera , Damir A. Safin","doi":"10.1016/j.inoche.2025.114180","DOIUrl":"10.1016/j.inoche.2025.114180","url":null,"abstract":"<div><div>This study reports the structural analysis and antitumor properties of a new dinuclear heteroleptic discrete Cd(II) complex, [Cd<sub>2</sub>(H<sub>2</sub>L)(NO<sub>3</sub>)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>]NO<sub>3</sub> (<strong>1</strong>), synthesized through the reaction of Cd(NO<sub>3</sub>)<sub>2</sub>·4H<sub>2</sub>O with bis(1-(pyridin-2-yl)-methylidene)carbazide (<strong>H</strong><sub><strong>2</strong></sub><strong>L</strong>). The asymmetric unit of <strong>1</strong> comprises two dinuclear heteroleptic [Cd<sub>2</sub>(H<sub>2</sub>L)(NO<sub>3</sub>)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>]<sup>+</sup> cations and two NO<sub>3</sub><sup>−</sup> anions. Each [Cd<sub>2</sub>(H<sub>2</sub>L)(NO<sub>3</sub>)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>]<sup>+</sup> cation features two distinct coordination polyhedra: [Cd(N^N′^O)(NO<sub>3</sub>)<sub>2</sub>(H<sub>2</sub>O)] and [Cd(N^N′^O)(NO<sub>3</sub>)(H<sub>2</sub>O)<sub>2</sub>]<sup>+</sup> (N^N′^O = one chelating pendant arm of <strong>H</strong><sub><strong>2</strong></sub><strong>L</strong>). Notably, the coordinated NO<sub>3</sub><sup>−</sup> anions exhibit either bidentate or anisobidentate coordination modes. The crystal structure of <strong>1</strong> is stabilized by a range of intermolecular interactions, including O–H⋯O, N–H⋯O, and π⋯π interactions. Additionally, antiparallel NO⋯NO interactions involving the coordinated nitrato ligands were identified and confirmed using NCIplot and QTAIM computational tools.</div><div>The cytotoxic and antiproliferative effects of <strong>1</strong>, as well as its inhibition of colonization and metastasis in the MCF-7, Huh7, HCT-116, and A549 cell lines, were investigated. While <strong>H</strong><sub><strong>2</strong></sub><strong>L</strong> exhibited no cytotoxicity, complex <strong>1</strong> demonstrated cell-killing activity, with IC<sub>50</sub> values of 17.05 µM for MCF-7, 14.02 µM for Huh7, and 27.27 µM for HCT-116 cells. In addition, <strong>1</strong> increased the expression of the DNA damage response protein p21 in HCT-116 cells. A549 cells showed lower sensitivity to <strong>1</strong> compared to the other cell lines examined in this study.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"176 ","pages":"Article 114180"},"PeriodicalIF":4.4,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143549284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zirconia on acid-treated halloysite as an efficient catalyst for conversion of mono-saccharides to 5-hydroxymethylfurfural

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-22 DOI: 10.1016/j.inoche.2025.114182

Samahe Sadjadi , Soheila Yaghoubi , Xuemin Zhong , Peng Yuan

An acidic catalyst was designed for catalyzing conversion of fructose into 5-hydroxymethylfurfural through a two-step approach. First, the textural features and acidity of halloysite nano clay were improved via acid-treatment. Secondly, zirconia, an acidic catalytic species, was synthesized through a simple procedure and immobilized on the acid-treated halloysite, resulting in an effective catalyst with increased acidity. Analysis of the catalyst confirmed that both acid-treatment and the incorporation of zirconia enhanced the acidity of the catalyst and improved its activity. To optimize the yield of the product, Response Surface Method was used and the effects of various reaction variables were studied. According to the results, yield of 93 % of the product was achieved within 60 min at 80 °C by using 25 wt% of the catalyst. The kinetic study showed that the activation energy was 61.6 kJ/mol. Thermodynamic parameters were determined to be 70 kJ/mol for enthalpy, −60 J/mol for entropy, and 91.5 kJ/mol for Gibbs free energy, respectively. Notably, the catalyst demonstrated high recyclability with minimal leaching of zirconia. In addition to its effectiveness in catalyzing the conversion of fructose, the catalyst exhibited efficient performance in the conversion of other monosaccharides.

{"title":"Zirconia on acid-treated halloysite as an efficient catalyst for conversion of mono-saccharides to 5-hydroxymethylfurfural","authors":"Samahe Sadjadi , Soheila Yaghoubi , Xuemin Zhong , Peng Yuan","doi":"10.1016/j.inoche.2025.114182","DOIUrl":"10.1016/j.inoche.2025.114182","url":null,"abstract":"<div><div>An acidic catalyst was designed for catalyzing conversion of fructose into 5-hydroxymethylfurfural through a two-step approach. First, the textural features and acidity of halloysite nano clay were improved via acid-treatment. Secondly, zirconia, an acidic catalytic species, was synthesized through a simple procedure and immobilized on the acid-treated halloysite, resulting in an effective catalyst with increased acidity. Analysis of the catalyst confirmed that both acid-treatment and the incorporation of zirconia enhanced the acidity of the catalyst and improved its activity. To optimize the yield of the product, Response Surface Method was used and the effects of various reaction variables were studied. According to the results, yield of 93 % of the product was achieved within 60 min at 80 °C by using 25 wt% of the catalyst. The kinetic study showed that the activation energy was 61.6 kJ/mol. Thermodynamic parameters were determined to be 70 kJ/mol for enthalpy, −60 J/mol for entropy, and 91.5 kJ/mol for Gibbs free energy, respectively. Notably, the catalyst demonstrated high recyclability with minimal leaching of zirconia. In addition to its effectiveness in catalyzing the conversion of fructose, the catalyst exhibited efficient performance in the conversion of other monosaccharides.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"175 ","pages":"Article 114182"},"PeriodicalIF":4.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Ni-doped ZnO thin films via spray pyrolysis method towards highly selective and sensitive acetone gas sensing

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114152

L.H. Kathwate , A.D. Kanwate , Y.P. Sarnikar , H.M. Rakhade , A. Kore , N.S. Barse , A.C. Mendhe

Nickel-doped zinc oxide (NiZ) thin films were synthesized on glass substrates using the spray pyrolysis deposition technique, with nickel concentration varying from 0 to 3 %. The structural, morphological, elemental analysis, optical, photoluminescent and acetone gas sensing characteristics at elevated temperatures were analyzed about Ni-doping concentrations. The XRD analysis supports the wurtzite hexagonal crystal structure and the average crystallite size reduced from 37 nm to 26 nm with the increasing Ni doping in ZnO. The progression from undoped ZnO (NiZ-0) to 3 % Ni-doped ZnO (NiZ-3) demonstrates a clear trend of morphological transition from elongated rods to granular particles. The EDS analysis was used to study the elemental analysis of Ni-doped ZnO. The values of energy bandgap were determined to be 3.30 eV, 3.29 eV, 3.26 eV and 3.24 eV for the Ni-doped ZnO films, with doping concentrations of 0, 1, 2, and 3 %, respectively. Photoluminescence analysis confirmed the formation of defects. The gas sensing investigation of acetone vapours indicates that the Ni-doped ZnO sample exhibited superior gas sensing response at 150 °C temperature compared to the other samples. The maximum response of the 3 % Ni-doped ZnO sensor is 83.11 %, with rapid response and recovery times at 25 ppm of acetone vapours.

{"title":"Fabrication of Ni-doped ZnO thin films via spray pyrolysis method towards highly selective and sensitive acetone gas sensing","authors":"L.H. Kathwate , A.D. Kanwate , Y.P. Sarnikar , H.M. Rakhade , A. Kore , N.S. Barse , A.C. Mendhe","doi":"10.1016/j.inoche.2025.114152","DOIUrl":"10.1016/j.inoche.2025.114152","url":null,"abstract":"<div><div>Nickel-doped zinc oxide (NiZ) thin films were synthesized on glass substrates using the spray pyrolysis deposition technique, with nickel concentration varying from 0 to 3 %. The structural, morphological, elemental analysis, optical, photoluminescent and acetone gas sensing characteristics at elevated temperatures were analyzed about Ni-doping concentrations. The XRD analysis supports the wurtzite hexagonal crystal structure and the average crystallite size reduced from 37 nm to 26 nm with the increasing Ni doping in ZnO. The progression from undoped ZnO (NiZ-0) to 3 % Ni-doped ZnO (NiZ-3) demonstrates a clear trend of morphological transition from elongated rods to granular particles. The EDS analysis was used to study the elemental analysis of Ni-doped ZnO. The values of energy bandgap were determined to be 3.30 eV, 3.29 eV, 3.26 eV and 3.24 eV for the Ni-doped ZnO films, with doping concentrations of 0, 1, 2, and 3 %, respectively. Photoluminescence analysis confirmed the formation of defects. The gas sensing investigation of acetone vapours indicates that the Ni-doped ZnO sample exhibited superior gas sensing response at 150 °C temperature compared to the other samples. The maximum response of the 3 % Ni-doped ZnO sensor is 83.11 %, with rapid response and recovery times at 25 ppm of acetone vapours.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"175 ","pages":"Article 114152"},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium borohydride-modified graphitic carbon nitride for enhanced tetracycline removal from aqueous solution

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114164

Jun Chen , Yuting Huang , Chengzi Zuo , Ying Wang , Zhongyu Cheng , Yifu Tan , Yunqi Man , Yanfei Liu , Zhenbao Liu

Graphite carbon nitride (g-C₃N₄) is a promising inorganic nonmetallic material. However, due to its small specific surface area and insufficient active centers, the adsorption capacity is very low. In order to improve the adsorption performance of g-C₃N₄, we employed a soft-template method to modify g-C₃N₄ with NaBH₄, resulting in the synthesis of the RCN-1-550 adsorbent, which exhibited a larger specific surface area and enhanced active sites. Compared to unmodified g-C₃N₄, RCN-1-550 exhibited a significantly increased specific surface area and introduced nitrogen vacancies and electron-deficient −C≡N groups, which greatly enhanced its adsorption capacity. RCN-1-550 had enhanced adsorption capacity for tetracycline (TC), which was 4.96 times that of the original g-C₃N₄, and the removal rate could reach 98.56 %. Additionally, RCN-1-550 achieved adsorption equilibrium within 10 min and could be reused at least five times. These results highlight the potential of RCN-1-550 as an effective and sustainable adsorbent for the removal of antibiotics from wastewater, offering a promising solution for environmental pollution control and water purification applications.

{"title":"Sodium borohydride-modified graphitic carbon nitride for enhanced tetracycline removal from aqueous solution","authors":"Jun Chen , Yuting Huang , Chengzi Zuo , Ying Wang , Zhongyu Cheng , Yifu Tan , Yunqi Man , Yanfei Liu , Zhenbao Liu","doi":"10.1016/j.inoche.2025.114164","DOIUrl":"10.1016/j.inoche.2025.114164","url":null,"abstract":"<div><div>Graphite carbon nitride (g-C<sub>3</sub>N<sub>4</sub>) is a promising inorganic nonmetallic material. However, due to its small specific surface area and insufficient active centers, the adsorption capacity is very low. In order to improve the adsorption performance of g-C<sub>3</sub>N<sub>4</sub>, we employed a soft-template method to modify g-C<sub>3</sub>N<sub>4</sub> with NaBH<sub>4</sub>, resulting in the synthesis of the RCN-1-550 adsorbent, which exhibited a larger specific surface area and enhanced active sites. Compared to unmodified g-C<sub>3</sub>N<sub>4</sub>, RCN-1-550 exhibited a significantly increased specific surface area and introduced nitrogen vacancies and electron-deficient −C≡N groups, which greatly enhanced its adsorption capacity. RCN-1-550 had enhanced adsorption capacity for tetracycline (TC), which was 4.96 times that of the original g-C<sub>3</sub>N<sub>4</sub>, and the removal rate could reach 98.56 %. Additionally, RCN-1-550 achieved adsorption equilibrium within 10 min and could be reused at least five times. These results highlight the potential of RCN-1-550 as an effective and sustainable adsorbent for the removal of antibiotics from wastewater, offering a promising solution for environmental pollution control and water purification applications.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"175 ","pages":"Article 114164"},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lignin derived carbon capped CuO assisted one pot synthesis of quinazolines and its antibacterial activity

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114166

Kathar Aazath , Kumar Aravindraj , Sagayaraj Jane Anto Simplica , Selvaraj Mohana Roopan , Murugan Arunachalapandi , Ashokan Anju Kanjirakkandy , Mohanasrinivasan Vaithilingam

A new nanocomposite system based on carbon supported CuO material was designed and confirmed by various techniques, such as XRD, FTIR, UV–Vis, PL and FE-SEM. A straightforward and scalable procedure that involves carbonizing lignin deposited on the surface of copper oxide nanoparticles produces CuO/C nanocomposites. In this study, CuO/C nanocomposites were used as photocatalysts for a one-pot synthesis of quinazolines under blue light irradiation. The catalyst showed excellent activity for synthesizing quinazolines (8 examples) with higher yield (84–94%) and easy recovery from the reaction mixture. The recovered CuO/C nanocomposites were used for 5 consecutive cycles, without significant loss of its catalytic activity. The synthesized compounds were also tested for antibacterial activity, and they exhibited considerable activity. This research will pave the way for the investigation of the use of lignin-derived carbon as a substrate for other types of nanoparticles, resulting in the creation of novel, eco-friendly catalysts for a variety of organic reactions.

{"title":"Lignin derived carbon capped CuO assisted one pot synthesis of quinazolines and its antibacterial activity","authors":"Kathar Aazath , Kumar Aravindraj , Sagayaraj Jane Anto Simplica , Selvaraj Mohana Roopan , Murugan Arunachalapandi , Ashokan Anju Kanjirakkandy , Mohanasrinivasan Vaithilingam","doi":"10.1016/j.inoche.2025.114166","DOIUrl":"10.1016/j.inoche.2025.114166","url":null,"abstract":"<div><div>A new nanocomposite system based on carbon supported CuO material was designed and confirmed by various techniques, such as XRD, FTIR, UV–Vis, PL and FE-SEM. A straightforward and scalable procedure that involves carbonizing lignin deposited on the surface of copper oxide nanoparticles produces CuO/C nanocomposites. In this study, CuO/C nanocomposites were used as photocatalysts for a one-pot synthesis of quinazolines under blue light irradiation. The catalyst showed excellent activity for synthesizing quinazolines (8 examples) with higher yield (84–94%) and easy recovery from the reaction mixture. The recovered CuO/C nanocomposites were used for 5 consecutive cycles, without significant loss of its catalytic activity. The synthesized compounds were also tested for antibacterial activity, and they exhibited considerable activity. This research will pave the way for the investigation of the use of lignin-derived carbon as a substrate for other types of nanoparticles, resulting in the creation of novel, eco-friendly catalysts for a variety of organic reactions.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"175 ","pages":"Article 114166"},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First-principles exploration of redox, electronic, thermoelectric, and thermodynamic properties of binary transition metal NaX1/3Mn2/3O2 (X = Ag, W, Zr) for enhanced performance of Na-ion batteries

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114157

Ahmad Usman , G. Murtaza , Ahmad Ayyaz , Imed Boukhris , Hafiz Irfan Ali , M. Basit Shakir , Hanof Dawas Alkhaldi , Maryam Touqir , Thamraa Alshahrani , Muhammad Umair Ashraf

Sodium-ion batteries have garnered significant interest as a cost-effective substitute for lithium-ion batteries. The density functional theory (DFT) analysis has been conducted to determine the various properties of NaX_1/3Mn_2/3O₂ (X = Ag, W, and Zr) compounds, an electrode material in a sodium-ion battery. The hexagonal structure of NaX_1/3Mn_2/3O₂ cathodes is predicted by the spin-polarized calculations of the Tb-mBJ approximation using the WIEN2k code. The unit cell volume of the studied compounds increased by substituting transition metals. However, the electronic properties reveal a decrease in the band gap in the spin-down calculation. The half-metallic nature of the compounds, exhibited by the reduction of their magnetic moments, suggested that these compounds are thermodynamically stable. The BoltzTraP code is employed to estimate the thermoelectric parameters, and the most significant value of the figure of merit was observed to be 0.92 for NaX_1/3Mn_2/3O₂. Electrochemical properties depict that these cathodes significantly improve the redox properties. The results provide novel properties by the substitutions of (X = Zr, Ag, and W) transition metals in the NaX_1/3Mn_2/3O₂ is 308 mAh/g capacity for NaMnO₂ with 3.23 V for NaX_1/3Mn_2/3O₂, can be used for the impressive performance of the Na-ion batteries.

钠离子电池作为一种具有成本效益的锂离子电池替代品，已经引起了人们的极大兴趣。为了确定钠离子电池电极材料 NaX1/3Mn2/3O2（X = Ag、W 和 Zr）化合物的各种特性，我们进行了密度泛函理论（DFT）分析。通过使用 WIEN2k 代码进行 Tb-mBJ 近似的自旋极化计算，预测了 NaX1/3Mn2/3O2 阴极的六方结构。所研究化合物的单胞体积随着过渡金属的替代而增大。然而，在自旋向下计算中，电子特性显示带隙有所减小。这些化合物的半金属性质表现为磁矩减小，这表明这些化合物在热力学上是稳定的。利用 BoltzTraP 代码估算了热电参数，观察到 NaX1/3Mn2/3O2 的最显著优点值为 0.92。电化学特性表明，这些阴极显著改善了氧化还原特性。通过在 NaX1/3Mn2/3O2 中取代（X = Zr、Ag 和 W）过渡金属，结果提供了新的特性，NaMnO2 的容量为 308 mAh/g，NaX1/3Mn2/3O2 的电压为 3.23 V，可用于镎离子电池，性能令人印象深刻。

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引用次数: 0

Enhanced chemo-photothermal therapy using cisplatin-loaded MXene nanosheets conjugated with Z(BTC) for effective HepG2 cancer treatment

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114128

Arwa Sultan Alqahtani , Amirah S. Alahmari , Zienab E. Eldin , Shehab Elbeltagi

Photothermal therapy (PTT) uses intense near-infrared (NIR) light to induce hyperthermia (HT), which leads to tumor cell destruction. This study introduces an innovative strategy using 2D MXene nanosheets conjugated with a zinc-benzenetricarboxylic acid (Zn-BTC) metal–organic framework (MOF) to form MX-Z(BTC), designed to enhance PTT efficacy. Cisplatin (CP) was loaded into MX-Z(BTC) and encapsulated within chitosan (CS), creating CP-MX-Z(BTC)@CS nanocomposites for anticancer applications. These nanocomposites were utilized for combined chemotherapy and PTT (chemo-PTT) under NIR irradiation, also functioning as drug delivery system (DDS). TEM analysis revealed the lamellar structure and spherical morphology of CP-MX-Z(BTC)@CS, with an average size of 38 nm. XPS analysis confirms strong interactions, enhancing stability and functionality and MXene/Z(BTC) composite integrates MXene’s conductive properties for stimuli-responsive drug release with Z(BTC)’s high drug-loading capacity and biocompatibility. The CP-MX-Z(BTC)@CS nanocomposites demonstrated high PT conversion efficiency, reaching 38.1 % at a concentration 30 µg/mL. The cumulative release of CP from CP-MX-Z(BTC)@CS at pH 7.4 was 59.5 %, with encapsulation efficiency up to 87.3 %. The main objective of this study was to enhance the therapeutic efficacy of CP-MX-Z(BTC)@CS nanocomposites for chemo-PTT against HepG2 liver cancer cells. MTT assay showed significant cytotoxicity, with CP-MX-Z(BTC)@CS displaying an IC₅₀ value of 17.22 µg/mL. Flow cytometry further confirmed that CP-MX-Z(BTC)@CS (chemo-PTT) induced 95.5 % total apoptosis. In an in vivo PTT study was conducted using a xenograft model in healthy BALB/c mice under NIR irradiation. The combination of CP-MX-Z(BTC)@CS and NIR irradiation (chemo-PTT) resulted in the smallest tumor weight (0.21 g) and the lowest relative tumor volume (0.85 mm³) compared to other treatment groups. CP-MX-Z(BTC)@CS indicated favorable biodistribution, effectively suppressed the growth of HepG2 cells, induced apoptosis, inhibited cancer proliferation, and prevented tumor recurrence. This multimodal chemo-PTT strategy significantly enhances anti-tumor efficacy, particularly when used in targeted DDS, indicating the potential for further optimization in cancer therapy.

{"title":"Enhanced chemo-photothermal therapy using cisplatin-loaded MXene nanosheets conjugated with Z(BTC) for effective HepG2 cancer treatment","authors":"Arwa Sultan Alqahtani , Amirah S. Alahmari , Zienab E. Eldin , Shehab Elbeltagi","doi":"10.1016/j.inoche.2025.114128","DOIUrl":"10.1016/j.inoche.2025.114128","url":null,"abstract":"<div><div>Photothermal therapy (PTT) uses intense near-infrared (NIR) light to induce hyperthermia (HT), which leads to tumor cell destruction. This study introduces an innovative strategy using 2D MXene nanosheets conjugated with a zinc-benzenetricarboxylic acid (Zn-BTC) metal–organic framework (MOF) to form MX-Z(BTC), designed to enhance PTT efficacy. Cisplatin (CP) was loaded into MX-Z(BTC) and encapsulated within chitosan (CS), creating CP-MX-Z(BTC)@CS nanocomposites for anticancer applications. These nanocomposites were utilized for combined chemotherapy and PTT (chemo-PTT) under NIR irradiation, also functioning as drug delivery system (DDS). TEM analysis revealed the lamellar structure and spherical morphology of CP-MX-Z(BTC)@CS, with an average size of 38 nm. XPS analysis confirms strong interactions, enhancing stability and functionality and MXene/Z(BTC) composite integrates MXene’s conductive properties for stimuli-responsive drug release with Z(BTC)’s high drug-loading capacity and biocompatibility. The CP-MX-Z(BTC)@CS nanocomposites demonstrated high PT conversion efficiency, reaching 38.1 % at a concentration 30 µg/mL. The cumulative release of CP from CP-MX-Z(BTC)@CS at pH 7.4 was 59.5 %, with encapsulation efficiency up to 87.3 %. The main objective of this study was to enhance the therapeutic efficacy of CP-MX-Z(BTC)@CS nanocomposites for chemo-PTT against HepG2 liver cancer cells. MTT assay showed significant cytotoxicity, with CP-MX-Z(BTC)@CS displaying an IC<sub>50</sub> value of 17.22 µg/mL. Flow cytometry further confirmed that CP-MX-Z(BTC)@CS (chemo-PTT) induced 95.5 % total apoptosis. In an in vivo PTT study was conducted using a xenograft model in healthy BALB/c mice under NIR irradiation. The combination of CP-MX-Z(BTC)@CS and NIR irradiation (chemo-PTT) resulted in the smallest tumor weight (0.21 g) and the lowest relative tumor volume (0.85 mm<sup>3</sup>) compared to other treatment groups. CP-MX-Z(BTC)@CS indicated favorable biodistribution, effectively suppressed the growth of HepG2 cells, induced apoptosis, inhibited cancer proliferation, and prevented tumor recurrence. This multimodal chemo-PTT strategy significantly enhances anti-tumor efficacy, particularly when used in targeted DDS, indicating the potential for further optimization in cancer therapy.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"176 ","pages":"Article 114128"},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cationic dye adsorption on the bioadsorbents based on chitosan and sodium alginate-iron oxide nanoparticles: Kinetic, isotherm and thermodynamic studies

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114160

Umran Duru Kamaci , Musa Kamaci

Herein, we fabricated a series of bioadsorbents based on chitosan and sodium alginate-iron oxide nanoparticles for the adsorption of methylene blue. As known, iron nanoparticle-based bioadsorbents have exhibited outstanding adsorption behavior while chitosan has been shown low adsorption due to its low surface area. For this reason, we aimed to increase the chitosan s surface area and dye adsorption behavior by mixing it with sodium alginate and iron nanoparticles. Some characterization techniques such as Fourier Transform-Infrared Spectroscopy (FT-IR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Brunauer-Emmett-Teller (BET), and thermogravimetric (TG) analysis were used to confirm the structure of bioadsorbents and to investigate crystalline, surface, and thermal properties. The adsorption of methylene blue onto the bioadsorbents was fitted to pseudo-second order kinetic and Langmuir isotherm models. The maximum methylene blue adsorption capacity was found between 162.77 and 212.77 mg/g. Moreover, thermodynamic parameters such as change in free energy (ΔG^o, in the range from −4. 524 to −0.748 kJ/mol), change in enthalpy (ΔH^o, in the range from −31.100 to −28.894 kJ/mol), and change in entropy (ΔS^o, in the range from −90.963 to −84.454 kJ mol⁻¹ K⁻¹) were calculated with negative values. The findings from the thermodynamic studies indicated that the adsorption process was spontaneous and exothermic.

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引用次数: 0

Atrazine removal and in-situ regeneration of molecularly imprinted metal-organic frameworks combined with persulfate

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114169

Feng Xu , Yanwei Shi , Jinjie You , Zeming Zhang , Aili Sun , Jiong Chen , Yin Lu , Shan Chen , Xizhi Shi

Removal of triazine herbicides in water combined with persulfate-based advanced oxidation processes has attracted significant interest. However, catalysts often have low activation efficiency. In this study, we hypothesized that the addition of molecular imprinting technology led to the improvement of the selective adsorption and catalytic degradation capabilities of metal–organic frameworks (MOFs) in atrazine solutions containing persulfates. A new molecularly imprinted metal–organic frameworks (MMOFs) was successfully fabricated, and characterized through Brunauer–Emmett–Teller surface area, scanning electron microscope, energy-dispersive spectroscopy, and Fourier transform infrared spectrometer. The absorption properties of the MMOFs were evaluated by considering various environmental factors, as well as adsorption isotherms, kinetics, and selective specificity experiments. Moreover, the degradation performance of the MMOFs was accessed by adsorption–degradation experiments, and the reusability of the MMOFs was estimated. Results showed that compared with MIL100(Fe), the total removal capacity of atrazine by the MMOFs increased about 2.72-fold. This enhancement was attributed to the higher selective recognition capability of the imprinted layers to adsorb atrazine, which was a chemisorption process and the higher catalytic degradation capability of the MMOFs to activate persulfate. Furthermore, the removal mechanisms indicated that MMOFs could simultaneously remove atrazine and in-situ regenerate. This study provides a novel strategy for the application of MMOFs in the rapid and highly efficient removal of atrazine in the water environment.

{"title":"Atrazine removal and in-situ regeneration of molecularly imprinted metal-organic frameworks combined with persulfate","authors":"Feng Xu , Yanwei Shi , Jinjie You , Zeming Zhang , Aili Sun , Jiong Chen , Yin Lu , Shan Chen , Xizhi Shi","doi":"10.1016/j.inoche.2025.114169","DOIUrl":"10.1016/j.inoche.2025.114169","url":null,"abstract":"<div><div>Removal of triazine herbicides in water combined with persulfate-based advanced oxidation processes has attracted significant interest. However, catalysts often have low activation efficiency. In this study, we hypothesized that the addition of molecular imprinting technology led to the improvement of the selective adsorption and catalytic degradation capabilities of metal–organic frameworks (MOFs) in atrazine solutions containing persulfates. A new molecularly imprinted metal–organic frameworks (MMOFs) was successfully fabricated, and characterized through Brunauer–Emmett–Teller surface area, scanning electron microscope, energy-dispersive spectroscopy, and Fourier transform infrared spectrometer. The absorption properties of the MMOFs were evaluated by considering various environmental factors, as well as adsorption isotherms, kinetics, and selective specificity experiments. Moreover, the degradation performance of the MMOFs was accessed by adsorption–degradation experiments, and the reusability of the MMOFs was estimated. Results showed that compared with MIL100(Fe), the total removal capacity of atrazine by the MMOFs increased about 2.72-fold. This enhancement was attributed to the higher selective recognition capability of the imprinted layers to adsorb atrazine, which was a chemisorption process and the higher catalytic degradation capability of the MMOFs to activate persulfate. Furthermore, the removal mechanisms indicated that MMOFs could simultaneously remove atrazine and in-situ regenerate. This study provides a novel strategy for the application of MMOFs in the rapid and highly efficient removal of atrazine in the water environment.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"175 ","pages":"Article 114169"},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Ni-Fe PBA derived NiO/Fe3O4 nanocomposites for chemocatalytic water oxidation and photocatalytic degradation of organic dyes

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications

Pub Date : 2025-02-21 DOI: 10.1016/j.inoche.2025.114170

Naeem Akram , Wenlan Ma , Shehla Riaz , Jia Guo , Ali Ahmad , Jide Wang

In this study, Ni-Fe-based Prussian Blue Analogues (Ni-Fe PBA) served as precursors, giving rise to a NiO/Fe₃O₄-based bimetallic catalyst that underwent comprehensive examination for both chemocatalytic water oxidation and photocatalytic degradation of organic dyes. The morphologies and chemical compositions of the precursor and resultant bimetallic catalysts were thoroughly characterized using XRD, SEM, XPS, mapping, and FTIR techniques. The results indicated that the catalytically active center is the NiO/Fe₃O₄-based bimetallic nanocomposite. The in-situ-synthesized bimetallic catalyst demonstrated remarkable catalytic oxidation activity when evaluated with Sodium Persulfate (PS) as an oxidant. Oxygen evolution results revealed an impressive catalytic water oxidation activity, with an O₂ production rate of approximately 1594.3 µmol·g⁻¹·h⁻¹.

Moreover, the NiO/Fe₃O₄ catalyst was utilized as a heterogeneous photocatalyst to activate photosensitizer (PS) for the two azo dye’s deterioration caused by the exposure to visible light. Both organic dyes were photocatalytically degraded with great efficiency when Fe₃O₄ and NiO were combined because they increased the catalyst’s capacity to absorb light. Electron Spin Resonance (ESR) and radical trapping studies revealed that sulfate (SO₄·^-) and hydroxyl (OH·) radicals played pivotal roles. The degradation mechanism and pathway for Rhodamine B (RhB) were also elucidated. The exceptional recyclability and stability of the NiO/Fe₃O₄ catalyst make it particularly promising for potential applications in water treatment, addressing challenges related to energy sustainability and environmental toxicity.

{"title":"Synthesis of Ni-Fe PBA derived NiO/Fe3O4 nanocomposites for chemocatalytic water oxidation and photocatalytic degradation of organic dyes","authors":"Naeem Akram , Wenlan Ma , Shehla Riaz , Jia Guo , Ali Ahmad , Jide Wang","doi":"10.1016/j.inoche.2025.114170","DOIUrl":"10.1016/j.inoche.2025.114170","url":null,"abstract":"<div><div>In this study, Ni-Fe-based Prussian Blue Analogues (Ni-Fe PBA) served as precursors, giving rise to a NiO/Fe<sub>3</sub>O<sub>4</sub>-based bimetallic catalyst that underwent comprehensive examination for both chemocatalytic water oxidation and photocatalytic degradation of organic dyes. The morphologies and chemical compositions of the precursor and resultant bimetallic catalysts were thoroughly characterized using XRD, SEM, XPS, mapping, and FTIR techniques. The results indicated that the catalytically active center is the NiO/Fe<sub>3</sub>O<sub>4</sub>-based bimetallic nanocomposite. The in-situ-synthesized bimetallic catalyst demonstrated remarkable catalytic oxidation activity when evaluated with Sodium Persulfate (PS) as an oxidant. Oxygen evolution results revealed an impressive catalytic water oxidation activity, with an O<sub>2</sub> production rate of approximately 1594.3 µmol·g<sup>−1</sup>·h<sup>−1</sup>.</div><div>Moreover, the NiO/Fe<sub>3</sub>O<sub>4</sub> catalyst was utilized as a heterogeneous photocatalyst to activate photosensitizer (PS) for the two azo dye’s deterioration caused by the exposure to visible light. Both organic dyes were photocatalytically degraded with great efficiency when Fe<sub>3</sub>O<sub>4</sub> and NiO were combined because they increased the catalyst’s capacity to absorb light. Electron Spin Resonance (ESR) and radical trapping studies revealed that sulfate (SO<sub>4</sub>·<sup>-</sup>) and hydroxyl (OH·) radicals played pivotal roles. The degradation mechanism and pathway for Rhodamine B (RhB) were also elucidated. The exceptional recyclability and stability of the NiO/Fe<sub>3</sub>O<sub>4</sub> catalyst make it particularly promising for potential applications in water treatment, addressing challenges related to energy sustainability and environmental toxicity.</div></div>","PeriodicalId":13609,"journal":{"name":"Inorganic Chemistry Communications","volume":"175 ","pages":"Article 114170"},"PeriodicalIF":4.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0