Integrative Medicine Research最新文献

英文中文

Anatomical features of the GV20 acupoint GV20穴的解剖特征

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-03-01 DOI: 10.1016/j.imr.2022.100919

Sang Hyun Kim , Ji-Yeun Park , Young Ho Lee

引用次数: 0

Development of clinical practice guidelines for Korean medicine: Towards evidence-based complementary and alternative medicine 韩国医学临床实践指南的发展:以证据为基础的补充和替代医学

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-03-01 DOI: 10.1016/j.imr.2023.100924

Seungwon Shin , Wonkyung Moon , Suran Kim , Seok Hee Chung , Jongwoo Kim , Namkwen Kim , Yoon Jae Lee , Minjung Park

Background

Since evidence-based medicine has been pursued in complementary and alternative medicine, the clinical practice guideline (CPG) has become a key factor in providing standardized and validated practices in Korean Medicine (KM). We aimed to review the current status and characteristics of the development, dissemination, and implementation of KM-CPGs.

Methods

We searched KM-CPGs and relevant publication via web-based databases. We organized the searching results focused on the year of publications and the development programs to show which and how KM-CPGs have been development. We also reviewed the manuals for KM-CPG development to introduce concise characteristics of the KM-CPGs published in Korea.

Results

The KM-CPGs have been developed according to manuals and standard templates for developing evidence-based KM-CPGs. First, CPG developers reviews the previously published CPGs for a clinical condition of interest and plans the CPG development. After finalizing the key clinical questions, the evidence is searched, selected, appraised, and analyzed following the internationally standardized methods. The quality of the KM-CPGs is controlled by a tri-step appraisal process. Second, the CPGs were submitted for the appraisal of the KM-CPG Review and Evaluation Committee. The committee evaluates the CPGs according to the AGREE II tool. Finally, the Steering Committee of the KoMIT project reviews the entire process of developing the CPGs and confirms it for public disclosure and dissemination.

Conclusion

Evidence-based KM from research to practice can be achieved with the attention and effort of multidisciplinary entities such as clinicians, practitioners, researchers, and policymakers for the CPGs.

背景随着循证医学在补充医学和替代医学中的应用，临床实践指南（CPG）已成为韩国医学提供标准化和有效实践的关键因素。我们旨在回顾KM-CPG的发展、传播和实施的现状和特点。方法通过网络数据库搜索KM CPG和相关出版物。我们组织了以出版年份和发展计划为重点的搜索结果，以显示KM CPG是如何发展的。我们还审查了KM-CPG开发手册，以介绍韩国出版的KM CPG的简明特征。结果KM CPG是根据基于证据的KM CPGs开发手册和标准模板开发的。首先，CPG开发人员针对感兴趣的临床状况审查先前发表的CPG，并计划CPG的开发。在确定了关键的临床问题后，按照国际标准化的方法对证据进行搜索、选择、评估和分析。KM CPG的质量由三步评估过程控制。其次，CPG已提交给KM-CPG审查和评估委员会进行评估。委员会根据AGREE II工具对CPG进行评估。最后，KoMIT项目指导委员会审查了制定CPG的整个过程，并确认其公开披露和传播。结论在临床医生、从业者、研究人员和CPG决策者等多学科实体的关注和努力下，可以实现从研究到实践的循证知识管理。

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引用次数: 1

The digital metaverse: Applications in artificial intelligence, medical education, and integrative health 数字元宇宙:在人工智能、医学教育和综合健康方面的应用

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-03-01 DOI: 10.1016/j.imr.2022.100917

Abhimanyu S. Ahuja , Bryce W. Polascik , Divyesh Doddapaneni , Eamonn S. Byrnes , Jayanth Sridhar

引用次数: 27

Rg3-enriched Korean red ginseng alleviates chloroquine-induced itch and dry skin pruritus in an MrgprA3-dependent manner in mice 富含rg3的高丽红参以mrgpra3依赖的方式减轻小鼠氯喹引起的瘙痒和干性皮肤瘙痒

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-03-01 DOI: 10.1016/j.imr.2022.100916

Wook-Joo Lee , Won-Sik Shim

Background

Previous studies have found that Korean red ginseng extract (KRG) has antipruritic effects, which can be attributed to the presence of Rg3, one of the most potent ginsenosides. Therefore, Rg3-enriched KRG extract (Rg3EKRG) is anticipated to have enhanced antipruritic effects. The present study was conducted to examine the effects of Rg3EKRG in acute chloroquine (CQ)-induced and chronic dry skin pruritus.

Methods

Calcium imaging technique was used in HE293T cells expressing MrgprA3 and TRPA1 (“MrgprA3/TRPA1”) and in primary cultures of mouse dorsal root ganglia (DRG) neurons. Mouse scratching behavior tests were performed on dry skin models. To verify the altered expression of itch-related genes, real-time RNA sequencing analysis and PCR were performed on DRG sections obtained from dry skin models.

Results

Rg3EKRG suppressed CQ-induced intracellular calcium changes to a greater degree than KRG. Rg3EKRG dose-dependently inhibited CQ-induced responses in MrgprA3/TRPA1 cells. Rg3EKRG likely targeted MrgprA3 rather than TRPA1 to exert its inhibitory effect. Further, Rg3EKRG strongly inhibited the scratching behavior in mice induced by acute CQ injection. Importantly, DRG neurons obtained from dry skin mice models showed increased mRNA levels of MrgprA3, and treatment with Rg3EKRG alleviated chronic dry skin conditions and suppressed spontaneous scratching behaviors.

Conclusion

The results of the present study imply that Rg3EKRG has a stronger antipruritic effect than KRG, inhibiting both acute CQ-induced and chronic dry skin pruritus in an MrgprA3-dependent manner. Therefore, Rg3EKRG is a potential antipruritic agent that can suppress acute and chronic itching at the peripheral sensory neuronal level.

背景先前的研究发现，韩国红参提取物具有止痒作用，这可归因于最有效的人参皂苷之一Rg3的存在。因此，预计富含Rg3的KRG提取物（Rg3EKRG）具有增强的止痒作用。本研究旨在检测Rg3EKRG对氯喹（CQ）诱导的急性和慢性干性皮肤瘙痒症的影响。方法应用钙成像技术对表达MrgprA3和TRPA1的HE293T细胞（“MrgprA3/TRPA1”）和小鼠背根神经节（DRG）神经元的原代培养进行检测。在干燥皮肤模型上进行小鼠抓挠行为测试。为了验证瘙痒相关基因表达的改变，对从干燥皮肤模型获得的DRG切片进行了实时RNA测序分析和PCR。结果Rg3EKRG对CQ诱导的细胞内钙离子变化的抑制作用大于KRG。Rg3EKRG剂量依赖性地抑制MrgprA3/TRPA1细胞中CQ诱导的应答。Rg3EKRG可能靶向MrgprA3而不是TRPA1以发挥其抑制作用。此外，Rg3EKRG强烈抑制急性CQ注射诱导的小鼠抓挠行为。重要的是，从干性皮肤小鼠模型中获得的DRG神经元显示出MrgprA3的mRNA水平增加，用Rg3EKRG治疗缓解了慢性干性皮肤状况并抑制了自发抓挠行为。结论Rg3EKRG具有比KRG更强的止痒作用，以MrgprA3依赖的方式抑制急性CQ诱导的和慢性干燥性皮肤瘙痒症。因此，Rg3EKRG是一种潜在的止痒剂，可以在外周感觉神经元水平上抑制急性和慢性瘙痒。

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引用次数: 0

Addressing cancer-related fatigue through sleep: A secondary analysis of a randomized trial comparing acupuncture and cognitive behavioral therapy for insomnia 通过睡眠解决癌症相关的疲劳:一项比较针灸和认知行为疗法治疗失眠的随机试验的二次分析

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-03-01 DOI: 10.1016/j.imr.2023.100922

Xiaotong Li , Kevin T. Liou , Susan Chimonas , Karolina Bryl , Greta Wong , Eugenie Spiguel , Susan Q. Li , Sheila N. Garland , Ting Bao , Jun J. Mao

Background

Fatigue is a troublesome symptom in cancer survivors that often results from disrupted sleep. We sought to assess whether two insomnia-focused non-pharmacological interventions are also effective for improving fatigue.

Methods

We analyzed data from a randomized clinical trial comparing cognitive behavioral therapy for insomnia (CBT-I) versus acupuncture for insomnia among cancer survivors. Participants were 109 patients who reported insomnia and moderate or worse fatigue. Interventions were delivered over eight weeks. Fatigue was evaluated at baseline, week 8, and week 20 using the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF). We used both mediation analysis and t-tests to explore the extent to which fatigue reduction was attributable to insomnia response.

Results

Compared to baseline, both CBT-I and acupuncture produced significant reductions in total MFSI-SF scores at week 8 (−17.1 points; 95% confidence interval [CI]: −21.1 to −13.1, and −13.2 points; 95% CI: -17.2 to -9.2, respectively, all p<0.001) and week 20 (-14.6 points; 95% CI: -18.6 to -10.6, and −14.2 points; 95% CI: -18.1 to -10.3. respectively, all p<0.001), with no significant between-group differences. MFSI-SF total scores at week 8 were significantly associated with sleep improvements in both CBT-I and acupuncture groups (p<0.001 and p=0.011, respectively). Insomnia responders demonstrated significantly greater improvements in mean MFSI-SF total scores compared with non-responders in the CBT-I group (p=0.016) but not in the acupuncture group.

Conclusion

CBT-I and acupuncture produced similar, clinically meaningful, and durable fatigue reductions in cancer survivors with insomnia, primarily through improvements in sleep. Acupuncture may also reduce fatigue through additional pathways.

Trial registration

ClinicalTrials.gov, identifier: NCT02356575

背景疲劳是癌症幸存者的一个麻烦症状，通常是由睡眠中断引起的。我们试图评估两种以失眠为重点的非药物干预措施是否也能有效改善疲劳。方法我们分析了癌症幸存者失眠认知行为疗法（CBT-I）与针灸治疗失眠的随机临床试验数据。参与者是109名报告失眠和中度或更严重疲劳的患者。干预措施在八周内实施。在基线、第8周和第20周使用多维疲劳症状清单简表（MFSI-SF）评估疲劳。我们使用中介分析和t检验来探讨失眠反应导致疲劳减轻的程度。结果与基线相比，CBT-I和针灸在第8周（−17.1分；95%置信区间[CI]:−21.1至−13.1和−13.2分；95%CI:-17.2至-9.2，分别为p＜0.001）和第20周（-14.6分；95%CI:-18.6至-10.6和−14.2分；95%CI:18.1至-10.3）的MFSI-SF总分均显著降低。所有p<；0.001），组间无显著差异。CBT-I组和针灸组在第8周的MFSI-SF总分均与睡眠改善显著相关（分别为p＜0.001和p＝0.011）。与CBT-I组的无应答者相比，失眠应答者的平均MFSI-SF总分有更大的改善（p=0.016），但针灸组没有。结论CBT-I和针灸在癌症失眠幸存者中产生了类似的、有临床意义的、持久的疲劳减轻，主要是通过改善睡眠。针灸还可以通过其他途径减轻疲劳。试验注册ClinicalTrials.gov，标识符：NCT02356575

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引用次数: 0

Efficacy of acupuncture for cardiopulmonary cerebral resuscitation: A systematic review and meta-analysis 针刺对心肺脑复苏的疗效:系统回顾和荟萃分析

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2023-03-01 DOI: 10.1016/j.imr.2023.100925

Yunlan Liu , Mengjuan Ren , Zhuoran Kuang , Xufei Luo , Huishan Li , Yikai Zhang , Wanxin Wen , Yefeng Cai , Xiaojia Ni , Yaolong Chen

Background

Cerebral resuscitation is one of the main therapeutic aims in the treatment of cardiac arrest (CA) patients who experience a return of spontaneous circulation (ROSC). However, the therapeutic effects of current treatments are not ideal. The purpose of this study was to evaluate the efficacy of neurological function of acupuncture combined with conventional cardiopulmonary cerebral resuscitationthe (CPCR) for patients after ROSC.

Methods

Seven electronic databases and other related websites were searched to identify studies on acupuncture combined with conventional CPCR for patients after ROSC. R software was used to conduct a meta-analysis, and the outcomes that could not be pooled were analyzed using a descriptive analysis.

Results

Seven RCTs involving 411 participants who had experienced ROSC were eligible for inclusion. The main acupoints were Neiguan (PC6), Shuigou (DU26), Baihui (DU20), Yongquan (KI1), and Sanyinjiao (SP6). Compared to conventional CPCR, acupuncture combined with conventional CPCR led to significantly higher Glasgow Coma Scale (GCS) scores on day 3 (mean difference (MD)=0.89, 95% CI: 0.43, 1.35, I² = 0%), day 5 (MD = 1.21, 95% CI: 0.27, 2.15; I² = 0%), and day 7 (MD = 1.92, 95% CI: 1.35, 2.50; I² = 0%).

Conclusion

Acupuncture-assisted conventional CPCR may have a potential role in improving neurological function in CA patients after ROSC, but the certainty of evidence is very low and more high-quality studies are required.

Protocol registration

This review was registered at the International Prospective Registry of Systematic Reviews (PROSPERO): CRD42021262262.

背景脑复苏是治疗经历自主循环恢复（ROSC）的心脏骤停（CA）患者的主要治疗目的之一。然而，目前的治疗效果并不理想。本研究旨在评价针刺联合常规心肺脑复苏（CPCR）对ROSC后患者神经功能的影响。方法检索7个电子数据库和其他相关网站，以确定针灸联合常规CPCR治疗ROSC后患者的研究。使用R软件进行荟萃分析，并使用描述性分析对无法合并的结果进行分析。结果7项随机对照试验，涉及411名经历过ROSC的参与者，符合入选条件。主要穴位为内关、水沟、百会、涌泉、三阴交。与常规CPCR相比，针灸联合常规CPCR在第3天（平均差异（MD）=0.89，95%CI:0.43，1.35，I2=0%）、第5天（MD=1.21，95%CI:0.27，2.15；I2=0%，和第7天（MD=1.92，95%CI:1.35，2.50；I2=0%）的格拉斯哥昏迷量表（GCS）得分显著更高。结论针刺辅助常规CPCR可能对改善ROSC后CA患者的神经功能有潜在作用，但证据的确定性很低，需要更多高质量的研究。方案注册本综述在国际前瞻性系统综述注册中心（PROSPERO）注册：CRD42021262262。

{"title":"Efficacy of acupuncture for cardiopulmonary cerebral resuscitation: A systematic review and meta-analysis","authors":"Yunlan Liu , Mengjuan Ren , Zhuoran Kuang , Xufei Luo , Huishan Li , Yikai Zhang , Wanxin Wen , Yefeng Cai , Xiaojia Ni , Yaolong Chen","doi":"10.1016/j.imr.2023.100925","DOIUrl":"10.1016/j.imr.2023.100925","url":null,"abstract":"<div><h3>Background</h3><p>Cerebral resuscitation is one of the main therapeutic aims in the treatment of cardiac arrest (CA) patients who experience a return of spontaneous circulation (ROSC). However, the therapeutic effects of current treatments are not ideal. The purpose of this study was to evaluate the efficacy of neurological function of acupuncture combined with conventional cardiopulmonary cerebral resuscitationthe (CPCR) for patients after ROSC.</p></div><div><h3>Methods</h3><p>Seven electronic databases and other related websites were searched to identify studies on acupuncture combined with conventional CPCR for patients after ROSC. R software was used to conduct a meta-analysis, and the outcomes that could not be pooled were analyzed using a descriptive analysis.</p></div><div><h3>Results</h3><p>Seven RCTs involving 411 participants who had experienced ROSC were eligible for inclusion. The main acupoints were <em>Neiguan</em> (PC6), <em>Shuigou</em> (DU26), <em>Baihui</em> (DU20), <em>Yongquan</em> (KI1), and <em>Sanyinjiao</em> (SP6). Compared to conventional CPCR, acupuncture combined with conventional CPCR led to significantly higher Glasgow Coma Scale (GCS) scores on day 3 (mean difference (MD)=0.89, 95% CI: 0.43, 1.35, I<sup>2</sup> = 0%), day 5 (MD = 1.21, 95% CI: 0.27, 2.15; I<sup>2</sup> = 0%), and day 7 (MD = 1.92, 95% CI: 1.35, 2.50; I<sup>2</sup> = 0%).</p></div><div><h3>Conclusion</h3><p>Acupuncture-assisted conventional CPCR may have a potential role in improving neurological function in CA patients after ROSC, but the certainty of evidence is very low and more high-quality studies are required.</p></div><div><h3>Protocol registration</h3><p>This review was registered at the International Prospective Registry of Systematic Reviews (PROSPERO): CRD42021262262.</p></div>","PeriodicalId":13644,"journal":{"name":"Integrative Medicine Research","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/56/main.PMC9971281.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9372150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture or cupping plus standard care versus standard care in moderate to severe COVID-19 patients: An assessor-blinded, randomized, controlled trial 中重度COVID-19患者针灸或拔罐加标准治疗与标准治疗:一项评估盲、随机对照试验

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2022-12-01 DOI: 10.1016/j.imr.2022.100898

Reihane Alipour , Saeidreza Jamalimoghadamsiahkali , Mehrdad Karimi , Asma Asadi , Haleh Ghaem , Mohammad Sadegh Adel-Mehraban , Amir Hooman Kazemi

Background

Non-pharmacological strategies that have been proposed by complementary medical systems, can be effective in management of COVID-19.

Methods

This study was designed as a three-arm, assessor-blinded, randomized controlled trial. A total of 139 hospitalized COVID-19 patients were randomly assigned into three groups: (1) acupuncture (ACUG), (2) cupping (CUPG), and (3) control (CTRG). All participants received conventional treatment. The primary study endpoint included changes in respiratory signs including oxygen saturation (SpO₂) and respiratory rate (RR). The secondary endpoints were COVID-19-related hospitalization duration and serious adverse events such as intensive care unit (ICU) admission, intubation or death, all up to day 30. Also, improvements in cough, dyspnea, chest tightness, oxygen demand, anorexia, headache, weakness, sore throat, and myalgia were evaluated.

Results

Forty-two patients in ACUG, 44 patients in CUPG, and 42 patients in CTRG completed the trial. After 3 days, SpO₂ and RR improved significantly in CUPG and ACUG compared with CTRG (effect size: 8.49 (6.4 to 10.57) and 8.51 (6.67 to 10.34), respectively: p<0.001). Compared with CTRG, patients in CUPG and ACUG recovered faster (mean difference: 6.58 (4.8 to 8.35) and 9.16 (7.16 to 11.15), respectively) and except for two patients in ACUG who were admitted to ICU, none of patients in ACUG or CUPG needed ICU or intubation (p<0.001 in comparison to CTRG). Amelioration of clinical COVID-19 related symptoms reached a high level of statistical significance in CUPG and ACUG in comparison with CTRG (p<0.01).

Conclusion

Cupping and acupuncture are promising safe and effective therapies in management of COVID-19. Trial registration: This study was registered at Iranian Registry of Clinical Trials: IRCT20201127049504N1 (https://en.irct.ir/trial/52621).

补充医疗系统提出的非药物策略可有效管理COVID-19。方法本研究设计为三组、评估盲、随机对照试验。139例新冠肺炎住院患者随机分为针刺组(ACUG)、拔火罐组(CUPG)和对照组(CTRG)。所有参与者均接受常规治疗。主要研究终点包括呼吸体征的变化，包括血氧饱和度(SpO2)和呼吸速率(RR)。次要终点是与covid -19相关的住院时间和严重不良事件，如重症监护病房(ICU)入院、插管或死亡，全部持续到第30天。此外，咳嗽、呼吸困难、胸闷、耗氧量、厌食症、头痛、虚弱、喉咙痛和肌痛的改善情况也进行了评估。结果ACUG组42例，CUPG组44例，CTRG组42例完成试验。3 d后，与CTRG相比，CUPG和ACUG的SpO2和RR显著改善(效应值分别为8.49(6.4 ~ 10.57)和8.51 (6.67 ~ 10.34):p<0.001)。与CTRG组相比，cuug组和ACUG组患者恢复更快(平均差值分别为6.58(4.8 ~ 8.35)和9.16(7.16 ~ 11.15))，除2例ACUG组患者入住ICU外，ACUG组和cuug组患者均无需ICU或插管(与CTRG组相比差值为0.001)。与CTRG组相比，CUPG组和ACUG组临床COVID-19相关症状的改善具有高度统计学意义(p<0.01)。结论拔火罐和针刺治疗新冠肺炎是一种安全有效的治疗方法。试验注册:本研究在伊朗临床试验注册中心注册:IRCT20201127049504N1 (https://en.irct.ir/trial/52621)。

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引用次数: 3

Increasing trends and impact of integrative medicine research: From 2012 to 2021 中西医结合研究的增长趋势和影响:从2012年到2021年

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2022-12-01 DOI: 10.1016/j.imr.2022.100884

Eunhye Song , Lin Ang , Myeong Soo Lee

引用次数: 3

Regulatory status of complementary medicine in Qatar: An update 卡塔尔补充医学的监管状况:最新情况

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2022-12-01 DOI: 10.1016/j.imr.2022.100896

Zainab AlMusleh , Tamer Aboushanab

引用次数: 0

Observational studies of traditional Chinese medicine may provide evidence nearly consistent with the randomized controlled trials: A meta-epidemiological study 中医观察性研究可能提供与随机对照试验几乎一致的证据:一项荟萃流行病学研究

IF 3.4 4区医学 Q1 Medicine

Integrative Medicine Research

Pub Date : 2022-12-01 DOI: 10.1016/j.imr.2022.100889

Haiqi Song , Nian Li , Wenjie Yang , Miaomiao Wu , Xiaoyang Liao , Yonggang Zhang

Background

In traditional Chinese medicine (TCM) field, the benefits of observational studies was more significant. Whether the evidence from observational studies agreed with RCTs in the field of TCM was still unclear.

Methods

A meta-epidemiological study was conducted. Meta-analyses and systematic reviews including cohort studies and case-control studies of TCM were included. Ratio of odds ratio (ROR) of randomized controlled trials and observational studies were calculated individually and intercomparisons were conducted by pool analysis.

Results

A total of 11 studies and 30 outcome pairs were included in the pool analysis. Using results from the observational studies as the reference group, the polled ROR comparing randomized controlled trials with observational studies was 1.23 (95% confidence interval 1.05 to 1.44, and 95% prediction interval 0.90 to 1.68). The ROR by subgroup analysis were 1.15 (95% confidence interval 0.96 to 1.38; 95% prediction interval 0.95 to 1.39) and 1.12 (95% confidence interval 0.86 to 1.46; 95% prediction interval 0.51 to 2.47) for cohort studies and case-control studies, respectively.

Conclusions

There is difference in pooled results between randomized controlled studies and observational studies on TCM. However, the prediction interval shows the difference is small, which suggests observational studies of TCM can be included in data analysis to provide evidence for TCM. Future studies are needed to verify the above conclusion.

在中医领域，观察性研究的益处更为显著。观察性研究的证据是否与中医领域的随机对照试验相一致尚不清楚。方法进行meta流行病学研究。meta分析和系统评价包括队列研究和病例对照研究。随机对照试验和观察性研究的优势比(ROR)分别计算，采用池分析进行相互比较。结果共纳入11项研究和30对结局对。以观察性研究结果为参照组，随机对照试验与观察性研究比较的投票ROR为1.23(95%可信区间1.05 ~ 1.44,95%预测区间0.90 ~ 1.68)。亚组分析的ROR为1.15(95%可信区间0.96 ~ 1.38;95%预测区间0.95 ~ 1.39)和1.12(95%置信区间0.86 ~ 1.46;队列研究和病例对照研究的95%预测区间分别为0.51 ~ 2.47)。结论随机对照研究与观察性研究的合并结果存在差异。然而，预测区间显示差异很小，这表明可以将中医的观察性研究纳入数据分析，为中医提供证据。以上结论需要进一步的研究来验证。

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引用次数: 0

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