Integrative Medicine Research最新文献_第8页

Corrigendum to: “Efficacy and safety of herbal medicine Gongjin-Dan and Ssanghwa-Tang in patients with chronic fatigue: A randomized, double-blind, placebo-controlled, clinical trial” Integr Med Res 2024;13:101025 《中药宫金丹和双花汤对慢性疲劳患者的疗效和安全性：一项随机、双盲、安慰剂对照的临床试验》的勘误表《综合医学杂志》2024；13:101025

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-16 DOI: 10.1016/j.imr.2025.101175

Jun-Yong Choi , Bom Choi , Ojin Kwon , Chang-Seob Seo , Ae-Ran Kim , Hyeun-kyoo Shin , Kibong Kim

引用次数: 0

Acupuncture treatment preserves soleus muscle mass and improves mitochondrial function in a rat model of disuse atrophy 针刺治疗保留比目鱼肌质量，改善废用性萎缩大鼠线粒体功能

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-16 DOI: 10.1016/j.imr.2025.101178

Sarah Mockler , Yun-Ju Fang , U-Ter Aondo Jia , Jinho Park , Joo Hyun Kim , Yoonjung Park , Adam J. Chicco , Masataka Umeda , Sukho Lee , Eunhee Chung

Background

Muscle atrophy leads to debilitating loss of physical capacity, particularly when alternative treatments are needed. Acupuncture is proposed as a potential therapy for disuse atrophy, but its effects on muscle biology remain unclear. This study evaluated the effects of acupuncture on soleus muscle mass and mitochondrial function in a rat model of immobilization-induced atrophy.

Methods

Female Sprague Dawley rats were assigned to three groups: Control (CON), casting-induced immobilization (CT), and CT with acupuncture (CT-A) (n = 8). Immobilization of the left hindlimb lasted for 14 days, and acupuncture was performed at specific acupoints (stomach-36, gallbladder-34) three times per week for 15 min. Mitochondrial function was assessed in saponin-permeabilized fibers, and signaling molecules regulating muscle mass were analyzed by Western blot.

Results

CT-A attenuated soleus muscle atrophy compared to CT. Under fatty acid substrate conditions, CT reduced complex I and II-supported oxidative phosphorylation (OXPHOS) compared to CON, while CT-A decreased respiratory leak and enhanced OXPHOS coupling relative to CT. Without fatty acids, CT-A decreased both respiratory leak and complex I and II-supported OXPHOS compared to CON, but differences between CT and CT-A were not significant. AMPKα activity (p-AMPKα/AMPKα) was significantly elevated in the CT group compared to the CON group, but returned to CON levels in the CT-A group. However, there were no changes in proteins associated with muscle atrophy or autophagy markers among the groups.

Conclusion

Acupuncture mitigates immobilization-induced muscle atrophy and preserves mitochondrial function, suggesting its potential as a therapeutic approach for muscle disuse conditions.

背景：肌肉萎缩导致身体机能的衰弱性丧失，特别是当需要替代治疗时。针刺被认为是废用性萎缩的潜在治疗方法，但其对肌肉生物学的影响尚不清楚。本研究评估了针刺对大鼠固定运动萎缩模型比目鱼肌质量和线粒体功能的影响。方法将雌性Sprague Dawley大鼠随机分为3组：对照组（CON）、穿刺固定组（CT）和针刺固定组（CT- a）。左后肢固定14天，针刺特定穴位（胃-36、胆囊-34），每周3次，每次15分钟。观察皂素渗透纤维的线粒体功能，并通过Western blot分析调节肌肉质量的信号分子。结果与CT相比，sct - a能减轻比目鱼肌萎缩。在脂肪酸底物条件下，与CON相比，CT减少了复合物I和ii支持的氧化磷酸化（OXPHOS），而CT- a相对于CT减少了呼吸泄漏并增强了OXPHOS偶联。在不含脂肪酸的情况下，与CON相比，CT- a减少了呼吸泄漏和复合物I和ii支持的OXPHOS，但CT和CT- a之间的差异不显著。与CON组相比，CT组AMPKα活性（p-AMPKα/AMPKα）显著升高，但在CT- a组恢复到CON水平。然而，与肌肉萎缩或自噬标志物相关的蛋白质在各组之间没有变化。结论针刺可减轻固定运动引起的肌肉萎缩，并保留线粒体功能，提示针刺可作为肌肉废用症的治疗方法。

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引用次数: 0

Predictors of the intention to use integrative medicine in psychiatric hospitals 精神病院使用中西医结合治疗意向的预测因素

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-14 DOI: 10.1016/j.imr.2025.101179

Corinne Schaub , Mohamed Faouzi , Julien Vonlanthen , Michaël Cordey , Pauline Marchand , Alexia Stantzos , Chantal BERNA , Kétia Alexandre

Background

The present study aimed to examine the influence of psychosocial and demographic factors on health professionals’ intention to integrate complementary and integrative medicine (CIM) into hospital-based psychiatric clinical practice. It also sought to validate the theoretical model derived from our previous exploratory study.

Method

A cross-sectional survey study using an online questionnaire sent to 4111 potential participants based on an adapted version of Triandis’ Theory of Interpersonal Behaviour (TIB).

Results

Participants reported high levels of positive attitudes towards CIM, with 61.6 % of the 1561 respondents reporting previous use in clinical practice and 37.8 % having received formal CIM training. Analysis of professionals’ intention to use CIM revealed four influential psychosocial factors - affect, perceived social norms, descriptive norms and past behaviour (p < 0.0001) - and three significant demographic factors - older age, a managerial position and fewer years of clinical practice (p < 0.05). With an area under the ROC curve of 95.53 %, the resulting model showed high discriminatory power and excellent fit.

Conclusions

These findings highlight the need for a supportive institutional environment to promote CIM. This requires the support of a wide range of professional leaders and the promotion of a shared CIM culture among healthcare professionals and interdisciplinary discussions.

本研究旨在探讨社会心理和人口因素对卫生专业人员将补充和结合医学（CIM）纳入医院精神病学临床实践的意向的影响。它还试图验证从我们之前的探索性研究中得出的理论模型。方法基于Triandis人际行为理论（TIB）的一个改编版本，采用一份在线调查问卷对4111名潜在参与者进行横断面调查研究。结果1561名受访者中有61.6%的人在临床实践中使用过CIM， 37.8%的人接受过正式的CIM培训。对专业人员使用CIM意向的分析揭示了四个影响心理社会因素——情感、感知社会规范、描述性规范和过去行为(p <；0.0001)，以及三个重要的人口统计学因素——年龄较大、管理职位和临床实践年数较少(p <；0.05)。该模型的ROC曲线下面积为95.53%，具有较高的判别能力和良好的拟合效果。结论：这些发现强调了促进CIM的支持性制度环境的必要性。这需要广泛的专业领导的支持，并在医疗保健专业人员和跨学科讨论中促进共享CIM文化。

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引用次数: 0

Should thread-embedding and auricular acupuncture be combined rather than used individually for non-specific chronic low back pain?: A double-blinded, randomized, sham-controlled trial 对于非特异性慢性腰痛，埋线和耳针是否应该联合使用，而不是单独使用？一项双盲、随机、假对照试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-13 DOI: 10.1016/j.imr.2025.101180

Thuy-Tu Long Pham , Nam Trung Le , Tin Trong Nguyen , Haoran Chu

Background

Non-specific chronic low back pain (NCLBP), the most common type, is a leading cause of global disability. The combined effect of thread-embedding acupuncture (TEA) and auricular acupuncture (AA) remains unclear. This study evaluates whether combining TEA and AA improves NCLBP management compared to either alone.

Methods

In this double-blind randomized controlled trial, 168 NCLBP patients were randomized into four groups (n = 42): TEA+AA, TEA+sham AA, AA+sham TEA, or sham both, alongside conventional treatment. The intervention lasted 4 weeks with a 4-week follow-up. The primary outcome was the Oswestry Disability Index (ODI); secondary outcomes included pain score, paracetamol use, quality of life, global improvement, and adverse events (AEs).

Results

In the intention-to-treat analysis, the acupuncture groups showed significantly lower ODI percentage scores compared to the sham group (p < 0.0001). Both the TEA+AA and TEA+sham AA groups outperformed the AA+sham TEA group (mean differences [MD]:9.1 and -7.5, respectively; p < 0.0001) at week 4 and achieved the minimal clinically important difference (MCID) during follow-up. The TEA+AA group showed greater improvement than the TEA+sham AA group at weeks 2 and 6; however, these differences did not reach the MCID. Secondary effectiveness outcomes followed a similar trend. The results were consistent with the per-protocol analysis. AEs were mild and self-limiting.

Conclusion

TEA and AA are safe and effective adjuncts for managing NCLBP, with TEA showing more sustained benefits. Adding AA into TEA may accelerate response, though clinical relevance remains uncertain. Further multicenter studies with longer follow-up and syndrome-based approaches are warranted.

Trial registration

ClinicalTrials.gov (NCT06682273).

非特异性慢性腰痛（NCLBP）是最常见的类型，是全球致残的主要原因。埋线针与耳针的联合作用尚不清楚。本研究评估与单独使用相比，TEA和AA联合使用是否能改善NCLBP的管理。方法在常规治疗的基础上，将168例NCLBP患者随机分为4组（n = 42）： TEA+AA组、TEA+假性AA组、AA+假性TEA组或两者均为假性TEA组。干预持续4周，随访4周。主要观察指标为Oswestry残疾指数（ODI）；次要结局包括疼痛评分、扑热息痛使用、生活质量、总体改善和不良事件（ae）。结果在意向治疗分析中，针刺组ODI百分比得分明显低于假手术组(p <；0.0001)。TEA+AA组和TEA+假性AA组均优于AA+假性TEA组(平均差异[MD]分别为9.1和-7.5；p & lt;0.0001)，并在随访期间达到最小临床重要差异（MCID）。在第2周和第6周，TEA+AA组比TEA+sham AA组有更大的改善；然而，这些差异没有达到MCID。次要有效性结果也遵循类似的趋势。结果与协议分析一致。ae是温和的和自我限制的。结论TEA和AA是治疗NCLBP安全有效的辅助手段，TEA疗效更持久。在TEA中加入AA可能会加速反应，但临床相关性仍不确定。进一步的多中心研究需要更长时间的随访和基于综合征的方法。试验注册：clinicaltrials .gov （NCT06682273）。

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引用次数: 0

Evaluating efficacy and safety of auricular acupressure in treating allergic rhinitis: A randomized controlled trial 评价耳穴按压治疗变应性鼻炎的疗效和安全性：一项随机对照试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-09 DOI: 10.1016/j.imr.2025.101177

Ngoc-Chau Le , Minh-Man Pham Bui , Dieu-Thuong Thi Trinh

Background

Allergic rhinitis significantly impacts health and quality of life, and symptom management remains a considerable challenge. This study aims to compare the treatment efficacy of auricular acupressure combined with fluticasone propionate versus fluticasone propionate alone for allergic rhinitis.

Methods

A randomized, double-blind, controlled clinical trial study was conducted with 90 patients diagnosed with allergic rhinitis according to ARIA 2008 guidelines. The control group (n = 45) received standard treatment, including fluticasone propionate, and sham auricular acupressure (SA), performed four times over four weeks. The intervention group (n = 45) received standard treatment with actual auricular acupressure (AA), performed four times over four weeks. Treatment efficacy was evaluated using a 100-mm visual analog scale (VAS) weekly and after four weeks of treatment, along with monitoring for adverse effects of auricular acupressure.

Results

After four weeks, the reduction in VAS scores for individual symptoms, including sneezing, runny nose, blocked nose, and itchy nose, showed mean differences between the control and intervention groups of 17.71 (95 % CI, 10.60–24.82); 22.73 (95 % CI, 15.71–29.76); 22.33 (95 % CI, 15.30–29.37); and 21.29 (95 % CI, 14.27–28.31) points, respectively (p < 0.0001). The RQLQ score, medication usage decreased significantly more in the intervention group than in the control group. Adverse effects were reported in 11.11 % of cases, mostly mild, transient, and not requiring additional treatment.

Conclusions

Auricular acupressure combined with fluticasone propionate provides effective and safe treatment for allergic rhinitis patients. Further interventional studies based on the classification of clinical syndromes in traditional medicine are warranted.

Trial registration: ClinicalTrials.gov, NCT06323304.

背景变应性鼻炎显著影响健康和生活质量，症状管理仍然是一个相当大的挑战。本研究旨在比较耳穴压联合丙酸氟替卡松与单用丙酸氟替卡松治疗变应性鼻炎的疗效。方法采用随机、双盲、对照临床试验方法，对90例根据ARIA 2008指南诊断为变应性鼻炎的患者进行研究。对照组（n = 45）给予标准治疗，包括丙酸氟替卡松和假耳穴按压（SA）， 4周内进行4次。干预组（n = 45）给予标准的实际耳穴按压（AA）治疗，4周内进行4次。采用100毫米视觉模拟量表（VAS）每周和治疗4周后评估治疗效果，同时监测耳穴按压的不良反应。结果4周后，对照组和干预组在打喷嚏、流鼻涕、鼻塞和鼻痒等症状的VAS评分下降，平均差异为17.71 (95% CI, 10.60-24.82)；22.73 (95% ci, 15.71 ~ 29.76)；22.33 (95% ci, 15.30-29.37)；和21.29 （95% CI, 14.27-28.31）点(p <；0.0001)。干预组RQLQ评分、用药情况下降明显高于对照组。11.11%的病例报告了不良反应，大多是轻微的，短暂的，不需要额外的治疗。结论穴位按压联合丙酸氟替卡松治疗变应性鼻炎安全有效。基于中医临床证候分类的进一步介入研究是有必要的。试验注册：ClinicalTrials.gov, NCT06323304。

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引用次数: 0

Traditional Chinese medicine therapies for insomnia: An umbrella review and evidence map 中医治疗失眠：概括性回顾和证据图谱

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-06-01 DOI: 10.1016/j.imr.2025.101176

Jinxiang Wang , Bing Bai , Ranran Zhu , Xintong Yu , Xiaoting Xu , Xiaomin Tu , Lei Fang

Background

An increasing number of systematic reviews and meta-analyses (SR/MAs) suggests traditional Chinese medicine therapies are effective for insomnia. We aimed to synthesize and evaluate the methodological quality of these studies through an umbrella review with an evidence map for improving evidence quality.

Methods

We searched 10 databases from inception to March 20, 2025, that investigated the effects of TCM therapies on sleep-related subjective or objective outcomes for insomnia. We assessed the methodological quality of included SR/MAs using A Measurement Tool to Assess systematic Reviews (AMSTAR 2) tool, evaluated the certainty of evidence with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool, and visually presented the results as an evidence map.

Results

Thirty-six SR/MAs included in this umbrella review described 3 TCM non-pharmacotherapies (i.e., acupuncture, Tuina massage, and Chinese exercises), and Chinese herbal medicine (CHM). The AMSTAR 2 results showed that 20 SR/MAs had high or moderate methodological quality, while the remaining studies were of low or critically low methodological quality. The evidence map showed high-quality SR/MAs supported the effect of acupuncture, Tuina massage, Chinese exercises, and CHM on overall sleep quality, while acupuncture, Tuina massage, and Chinese exercises could also improve anxiety and depression. Moreover, acupuncture and Tuina massage might improve objective outcomes such as polysomnography parameters and 5-hydroxytryptamine level.

Conclusions

Acupuncture, Tuina massage, and Chinese exercises are effective in improving overall sleep quality and emotional outcomes and have potential effects on objective sleep parameters. There is sufficient evidence that several CHM formulas could improve sleep quality. However, the methodological quality of SR/MAs needs further improvement.

Protocol registration

PROSPERO, CRD42022347769.

越来越多的系统综述和荟萃分析（SR/MAs）表明，中药治疗失眠是有效的。我们的目的是综合和评价这些研究的方法学质量，通过一个综合评价和证据图来提高证据质量。方法我们检索了从成立到2025年3月20日的10个数据库，这些数据库调查了中医疗法对失眠患者睡眠相关的主观或客观结局的影响。我们使用评估系统评价的测量工具（AMSTAR 2）工具评估纳入的SR/ ma的方法学质量，使用建议评估、发展和评价分级（GRADE）工具评估证据的确定性，并以证据图的形式可视化地呈现结果。结果纳入的36个SR/ ma共涉及3种中医非药物疗法（即针灸、推拿和中医运动）和中草药（CHM）。AMSTAR 2结果显示，20个SR/ ma具有高或中等的方法学质量，而其余研究的方法学质量较低或极低。证据图显示，高质量的SR/MAs支持针灸、推拿按摩、中医锻炼对整体睡眠质量的影响，同时针灸、推拿按摩和中医锻炼也能改善焦虑和抑郁。此外，针灸和推拿按摩可能改善客观结果，如多导睡眠图参数和5-羟色胺水平。结论针刺、推拿按摩和中医操能有效改善整体睡眠质量和情绪结局，并对客观睡眠参数有潜在影响。有足够的证据表明，几种中药配方可以改善睡眠质量。然而，SR/MAs的方法学质量需要进一步提高。协议注册普洛斯普洛斯，CRD42022347769。

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引用次数: 0

Efficacy of herbal medicine (Thatbunjob) in the treatment of foodborne illness: A placebo-controlled, randomized trial 草药（Thatbunjob）治疗食源性疾病的疗效：一项安慰剂对照的随机试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-05-25 DOI: 10.1016/j.imr.2025.101153

Jaiboonya Jaicharoensub , Sumalee Panthong , Intouch Sakpakdeejaroen , Thanee Eiamsitrakoon , Patommatat Bhanthumkomol

Background

Foodborne illness (FI) causes 600 million cases and 420,000 deaths annually. Current treatments focus on rehydration and antispasmodic medications for managing dehydration and abdominal pain (AP). However, alternative therapies, especially those derived from natural ingredients, are needed. This study investigates the potential efficacy of herbal medicine,Thatbunjob as a complementary therapy for FI-related AP.

Methods

A double-blind, randomized, placebo-controlled clinical trial assessed the efficacy of Thatbunjob in relieving AP in FI patients. A total of 114 patients, aged 18–60, with AP and diarrhea (≥3 episodes in 24 h), received either two 500 mg capsules of Thatbunjob or a placebo three times daily for three days. Both groups also received standard oral rehydration therapy. Primary outcomes included AP intensity using a visual analog scale (VAS) at 24 h, while secondary outcomes included pain at 48 and 72 h, responder rates, hyoscine butyl bromide usage, stool frequency, and adverse events.

Results

The Thatbunjob group showed significantly greater reduction in AP compared to the placebo. VAS scores decreased from 5.69 to 2.95 at 24 h (P < 0.001), and pain relief persisted at 48 (1.43 vs. 3.05, P < 0.001) and 72 h (0.32 vs. 1.86, P < 0.001). Thatbunjob also reduced the need for hyoscine tablets and decreased stool frequency compared to placebo.

Conclusion

This study demonstrates that Thatbunjob, when combined with standard rehydration therapy, effectively alleviates AP and reduces stool frequency in FI patients.

Trial registration

Thai Clinical Trials Registry, TCTR20220823001.

食源性疾病（FI）每年造成6亿例病例和42万人死亡。目前的治疗重点是补液和抗痉挛药物治疗脱水和腹痛（AP）。然而，需要替代疗法，特别是那些从天然成分中提取的疗法。本研究探讨了草药Thatbunjob作为FI相关AP的补充疗法的潜在疗效。方法采用双盲、随机、安慰剂对照临床试验评估Thatbunjob缓解FI患者AP的疗效。114例患者，年龄18-60岁，伴有AP和腹泻（24小时内≥3次发作），每日3次，服用两次500 mg Thatbunjob胶囊或安慰剂，连续3天。两组患者均接受标准的口服补液治疗。主要结果包括24 h时视觉模拟量表（VAS）的AP强度，次要结果包括48和72 h时的疼痛、反应率、丁基溴的使用、大便频率和不良事件。结果与安慰剂组相比，Thatbunjob组的AP明显减少。24 h时VAS评分由5.69降至2.95 (P <；0.001)，疼痛缓解持续为48 (1.43 vs. 3.05, P <；0.001)和72 h (0.32 vs. 1.86, P <；0.001)。与安慰剂相比，这项研究还减少了对海莨菪碱片的需求，并减少了大便频率。结论本研究表明，bunjob联合标准补液治疗可有效缓解FI患者的AP并减少大便频率。试验注册泰国临床试验注册中心，TCTR20220823001。

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引用次数: 0

Herbal decoctions for dysmenorrhea under universal health coverage pilot project: Evidence from a nationwide claims database in the Republic of Korea 全民健康覆盖试点项目下治疗痛经的草药煎剂：来自大韩民国全国索赔数据库的证据

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-05-21 DOI: 10.1016/j.imr.2025.101152

Kyeore Bae , Minjung Park , Junhyeok Yi

Background

Despite its high prevalence, dysmenorrhea is an underestimated gynecological disorder. To enhance the service coverage, the Pilot Project for Expanding National Health Insurance (NHI) Coverage to Herbal Decoctions (HDs) was implemented in the Republic of Korea from November 2020. This study aimed to assess the effectiveness and safety of HDs for dysmenorrhea at a nationwide level. Additionally, its impact on accessibility was explored.

Methods

This retrospective observational study used claims data from the pilot project (November 1, 2020, to April 28, 2024). A linear mixed-effects model was used to estimate symptom improvement during the HD exposure period. Time series data decomposition and structural change points detection were performed using NHI statistics on dysmenorrhea patient counts for those who received medical services between 2014 and 2023.

Results

Among 39,574 participants, a descriptive analysis of 7016 suggested a tendency to receive HD treatment for moderate-to-severe symptoms. Effectiveness analysis demonstrated that HD significantly reduced symptom severity over time (β = –0.072, p < 0.001). Adverse events were reported by 0.58 % of the patients, mostly involving gastrointestinal symptoms. Following the initiation of the pilot project, a significant increase in the number of patients with dysmenorrhea receiving traditional Korean medicine (TKM) services was observed.

Conclusion

The nationwide pilot project showed clinical effectiveness and a manageable safety profile of HDs for dysmenorrhea. The universal health coverage initiative appeared to have improved the accessibility of TKM services for managing dysmenorrhea. Further robust research utilizing nationwide real-world data is required to validate these findings.

背景：尽管痛经的发病率很高，但它是一种被低估的妇科疾病。为扩大服务覆盖面，自2020年11月起，韩国实施了将国民健康保险（NHI）覆盖面扩大到草药煎剂（HDs）的试点项目。本研究的目的是在全国范围内评估HDs治疗痛经的有效性和安全性。此外，还探讨了其对可达性的影响。方法回顾性观察研究使用试点项目（2020年11月1日至2024年4月28日）的索赔数据。使用线性混合效应模型来估计HD暴露期间症状的改善情况。对2014 - 2023年接受医疗服务的痛经患者数量进行NHI统计，进行时间序列数据分解和结构变化点检测。结果在39,574名参与者中，对7016名参与者的描述性分析表明，他们倾向于在中度至重度症状时接受HD治疗。有效性分析显示，随着时间的推移，HD显著降低了症状严重程度(β = -0.072, p <；0.001)。有0.58%的患者报告了不良事件，主要涉及胃肠道症状。试点项目启动后，观察到接受韩国传统医学服务的痛经患者人数显著增加。结论hdd治疗痛经的临床效果良好，安全性可控。全民健康覆盖倡议似乎改善了治疗痛经的TKM服务的可及性。需要进一步利用全国实际数据进行强有力的研究来验证这些发现。

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引用次数: 0

Effect of acupoint catgut embedding for simple obesity in adults: A randomized controlled double-blind trial 穴位埋线治疗成人单纯性肥胖：一项随机对照双盲试验

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-05-14 DOI: 10.1016/j.imr.2025.101151

Qiwang Yang , Nenggui Xu , Lidong Guo , Hui Li , Xiaoyan Li , Qingmei Zeng , Wenyue Zhang , Shiping Li , Wei Yi

Background

Acupoint catgut embedding (ACE) is considered an effective treatment for simple obesity, though high-quality clinical evidence remains lacking. To establish a solid evidence base in obesity management, well-designed studies are needed to verify both the short- and long-term efficacy and safety of ACE.

Methods

In this randomized controlled, double-blind trial, 120 patients with simple obesity were initially allocated to verum ACE (n = 60) or sham ACE group (n = 60) .One participant allocated to the verum group was excluded during screening for failing to meet BMI criteria (<24 kg/m²), resulting in a final cohort of 59 verum and 60 sham cases completing the 12-week intervention and 12-week follow-up. The primary outcome was the change in body weight from baseline to week 12. Secondary outcomes included body weight change at 12-week follow-up, cumulative weight change by week 24, changes in body mass index (BMI), body fat status, body circumference, and appetite indicators.

Results

After the 12-week treatment, both groups showed varying degrees of weight loss, with the verum ACE group experiencing a significantly greater reduction compared to the sham group. At the 12-week follow-up, the visceral fat grade of the verum group was significantly greater than that of sham group. The waist, upper arm, and thigh girths in the verum group decreased significantly more than that in sham group; the reduction degree of waist-hip ratio was significantly better than that in the sham group at all time points. Additionally, the cumulative reduction in appetite factors was significantly higher in the verum group compared to the sham group.

Conclusion

ACE can significantly reduce body weight, and is both long-lasting and safe. It also has beneficial effects on fat distribution, body circumference, and appetite, making it a promising complementary therapy for simple obesity.

Trial registration

Chinese Clinical Trial Registry, ChiCTR2100046693.

穴位埋线（ACE）被认为是治疗单纯性肥胖的有效方法，但仍缺乏高质量的临床证据。为了在肥胖管理中建立坚实的证据基础，需要精心设计的研究来验证ACE的短期和长期疗效和安全性。方法在本随机对照双盲试验中，120例单纯性肥胖患者最初被分配到verum ACE组（n = 60）和sham ACE组（n = 60），其中verum组1例因BMI不符合标准（24 kg/m²）而被排除，最终有59例verum和60例sham患者完成了12周的干预和12周的随访。主要结局是体重从基线到第12周的变化。次要结局包括随访12周时的体重变化、第24周时的累计体重变化、体重指数（BMI）、体脂状况、体围和食欲指标的变化。结果治疗12周后，两组患者均出现不同程度的体重减轻，其中verum ACE组的体重减轻幅度明显大于sham组。随访12周，肺脏脂肪分级明显高于假手术组。髋部组大鼠腰部、上臂、大腿围围较假手术组明显减小；各时间点腰臀比减小程度均明显优于假手术组。此外，与假药组相比，verum组的食欲因素累积减少量明显更高。结论ace能显著降低体重，且长效、安全。它还对脂肪分布、体围和食欲有有益的影响，使其成为单纯性肥胖的一种有希望的补充疗法。中国临床试验注册中心，ChiCTR2100046693。

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引用次数: 0

Evaluating and ranking guidelines on traditional and integrative medicine globally: Establishment of the International STAR-TIM Committee 全球传统医学和中西医结合指南的评估和排名：国际STAR-TIM委员会的建立

IF 2.8 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research

Pub Date : 2025-05-04 DOI: 10.1016/j.imr.2025.101150

Xuan Yu , Yishan Qin , Janne Estill , Hui Liu , Xu Wang , Zhaoxiang Bian , Yaolong Chen , on behalf of STAR Secretariat

To further enhance the quality and transparency of practice guidelines and consensus statements, the Scientific, Transparent, and Applicable Rankings (STAR) working group was officially established and commenced its work in 2021. The STAR tool contains 39 items grouped into 11 domains, with each domain and item assigned to a weight that reflects its importance. In 2021–2022, a total of 266 Chinese Traditional and Integrative Medicine (TIM) guidelines and consensus statements met the inclusion criteria for STAR evaluation. After evaluating these TIM guidelines and consensus statements, the highest STAR score achieved was 96.5 (out of 100), with a median score 23.3 and a mean score of 32.0. As the number of TIM guidelines and consensus statements published globally continues to increase, the STAR Secretariat aims to establish an International STAR Specialty Committee for TIM. Utilizing the integrated STAR evaluation system and large language models, the committee seeks to enhance the efficiency of evaluations without compromising accuracy. This initiative aims to conduct evaluations of international TIM guidelines and consensus statements, thereby improving their quality and transparency. Additionally, it will assess the importance and necessity of developing the International STAR-TIM Extension.

为进一步提高实践指南和共识声明的质量和透明度，科学、透明和适用排名（STAR）工作组于2021年正式成立并开始工作。STAR工具包含分为11个领域的39个项目，每个领域和项目分配一个反映其重要性的权重。在2021-2022年，共有266份中医与中西医结合（TIM）指南和共识声明符合STAR评估的纳入标准。在评估这些TIM指南和共识声明后，STAR得分最高达到96.5（满分100分），中位数得分为23.3，平均得分为32.0。随着全球出版的TIM指南和协商一致声明的数量不断增加，STAR秘书处的目标是为TIM建立一个国际STAR专业委员会。委员会利用综合STAR评价系统和大型语言模型，力求在不损害准确性的情况下提高评价的效率。这项倡议旨在对国际TIM准则和协商一致声明进行评价，从而提高其质量和透明度。此外，它将评估发展国际STAR-TIM扩展的重要性和必要性。

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