Sujitra Raj Genga Raj, Chean Hui Ng, S. Mohd-Said, Kent Yu
{"title":"Antibacterial Potential of Aqueous Extracts and Compounds from Selected Brown Seaweeds","authors":"Sujitra Raj Genga Raj, Chean Hui Ng, S. Mohd-Said, Kent Yu","doi":"10.26689/itps.v2i1.804","DOIUrl":"https://doi.org/10.26689/itps.v2i1.804","url":null,"abstract":"<jats:p />","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80460900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
It is our pleasure to release the second issue (Volume 2, Issue 1) of INNOSC Theranostics and Pharmacological Sciences. In line with the journal’s primary scope – “therapeutic and diagnosis,” this issue published articles pertaining to the major aspects such as therapeutics, medical diagnosis, medicinal chemistry, drug metabolism and transport, nanomedicine, translational medicine, and molecular and cellular pharmacology. This issue has five original articles and one review article that was submitted by authors from different countries of origin. One of the research articles entitled “Formulation Development and in vitro Characterization of Zolmitriptan Controlled Release Drug Delivery Systems” by Pandala et al., made an effort in developing the extended-release of zolmitriptan matrix to treat migraine [1]. Authors used the formulations from natural polymers/gums and have shown a promising delivery system which can enhance the bioavailability and has potential for greater therapeutic efficacy. The second article by Katagi et al. worked on “Schiff Base Oxime Derivatives Reactivate Chlorpyrifos-induced Acetylcholinesterase Inhibition” [2]. This study is primarily aimed at synthesizing a series of Schiff base oximes and assessing the in vitro reactivating potency against chlorpyrifosinhibited acetylcholinesterase. Based on the study, authors concluded that compounds with chloroand nitro-substitution on the 4th position yielded a better activity against chlorpyrifosinhibited acetylcholinesterase. In addition, the above Schiff base oximes are claimed to be promising, because of their sufficient reactivation strength at lower concentration. The third article was authored by Razalli et al. on “Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle” which delineates the carrier potential of gold nanoparticle [3]. To demonstrate their notion, the herbal extracts were capped on the gold nanoparticle and tested against the bacterial strains. The nanoparticle used in this study was characterized morphologically, chemically, and biologically. Authors demonstrated the inhibition potential of desired plant extracts and their higher antimicrobial activity mediated by the gold nanoparticle conjugation. Regarding the fourth article, Teh et al. have studied on “Toxicity Effect of Bougainvillea glabra (Paper Flower) Water Extracts on Zebrafish Embryo” [4]. This article assessed the acute toxicity and the potential teratogenic activity of water extracts of B. glabra bracts on zebrafish embryos. The researchers participated in this work concluded that the water extracts derived from the pink, purple, and dark pink bracts of B. glabra have mild toxicity toward embryo, a model for studies in pharmacology in the future. The next article under the technical aspect is on “Antibacterial Potential of Aqueous Extracts and Compounds from Selected Brown Seaweeds” by Genga Raj et al., in which authors took a great effort to demonstrate the antimicrobial
{"title":"Approaches in Theranostics and Pharmacological Sciences","authors":"S. Gopinath","doi":"10.26689/itps.v2i1.883","DOIUrl":"https://doi.org/10.26689/itps.v2i1.883","url":null,"abstract":"It is our pleasure to release the second issue (Volume 2, Issue 1) of INNOSC Theranostics and Pharmacological Sciences. In line with the journal’s primary scope – “therapeutic and diagnosis,” this issue published articles pertaining to the major aspects such as therapeutics, medical diagnosis, medicinal chemistry, drug metabolism and transport, nanomedicine, translational medicine, and molecular and cellular pharmacology. This issue has five original articles and one review article that was submitted by authors from different countries of origin. One of the research articles entitled “Formulation Development and in vitro Characterization of Zolmitriptan Controlled Release Drug Delivery Systems” by Pandala et al., made an effort in developing the extended-release of zolmitriptan matrix to treat migraine [1]. Authors used the formulations from natural polymers/gums and have shown a promising delivery system which can enhance the bioavailability and has potential for greater therapeutic efficacy. The second article by Katagi et al. worked on “Schiff Base Oxime Derivatives Reactivate Chlorpyrifos-induced Acetylcholinesterase Inhibition” [2]. This study is primarily aimed at synthesizing a series of Schiff base oximes and assessing the in vitro reactivating potency against chlorpyrifosinhibited acetylcholinesterase. Based on the study, authors concluded that compounds with chloroand nitro-substitution on the 4th position yielded a better activity against chlorpyrifosinhibited acetylcholinesterase. In addition, the above Schiff base oximes are claimed to be promising, because of their sufficient reactivation strength at lower concentration. The third article was authored by Razalli et al. on “Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle” which delineates the carrier potential of gold nanoparticle [3]. To demonstrate their notion, the herbal extracts were capped on the gold nanoparticle and tested against the bacterial strains. The nanoparticle used in this study was characterized morphologically, chemically, and biologically. Authors demonstrated the inhibition potential of desired plant extracts and their higher antimicrobial activity mediated by the gold nanoparticle conjugation. Regarding the fourth article, Teh et al. have studied on “Toxicity Effect of Bougainvillea glabra (Paper Flower) Water Extracts on Zebrafish Embryo” [4]. This article assessed the acute toxicity and the potential teratogenic activity of water extracts of B. glabra bracts on zebrafish embryos. The researchers participated in this work concluded that the water extracts derived from the pink, purple, and dark pink bracts of B. glabra have mild toxicity toward embryo, a model for studies in pharmacology in the future. The next article under the technical aspect is on “Antibacterial Potential of Aqueous Extracts and Compounds from Selected Brown Seaweeds” by Genga Raj et al., in which authors took a great effort to demonstrate the antimicrobial ","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83017013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Toxicity Effect of Bougainvillea glabra (Paper Flower) Water Extracts on Zebrafish Embryo","authors":"Lu E Teh, C. S. Kue, Chean Hui Ng, B. F. Lau","doi":"10.26689/itps.v2i1.780","DOIUrl":"https://doi.org/10.26689/itps.v2i1.780","url":null,"abstract":"<jats:p />","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78585969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Razalli, S. Gopinath, F. Kasim, Ahmad Radi Wan Yaakub, P. Anbu
Background: Herbal extracts have been traditionally used as antibacterial agents, and different strategies have been proposed to enhance their antimicrobial activities. This research aimed to assess the antimicrobial potential of Andrographis paniculata conjugated gold nanoparticle (GNP) compounds against Escherichia coli and Bacillus subtilis.Methods: Herbal extract was conjugated with GNP through electrostatic interaction, and characterization was carried out by Fourier-transmission infrared spectroscopy, screening electron microscopy, and transmission electron microscopy and supported by energy-dispersive X-ray spectroscopy. Antibacterial activity of the herbal extract and GNP conjugation was evaluated by disc diffusion assay.Results: Chemical and morphological characterizations of the GNP and herbal extract conjugate revealed intactness of the GNP. In disc diffusion assay, the inhibition zone formed by these compounds was measured for both microorganisms, and they were in the range of 0.6-0.9 cm for the herbal extract. When the herbal extract conjugated with GNP, the zone was between 0.8 and 1.1 cm.Conclusion: This study demonstrated the potentiality of GNP to carry the antibacterial compounds from the herbal extract.
{"title":"Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle","authors":"N. Razalli, S. Gopinath, F. Kasim, Ahmad Radi Wan Yaakub, P. Anbu","doi":"10.26689/itps.v2i1.744","DOIUrl":"https://doi.org/10.26689/itps.v2i1.744","url":null,"abstract":"Background: Herbal extracts have been traditionally used as antibacterial agents, and different strategies have been proposed to enhance their antimicrobial activities. This research aimed to assess the antimicrobial potential of Andrographis paniculata conjugated gold nanoparticle (GNP) compounds against Escherichia coli and Bacillus subtilis.Methods: Herbal extract was conjugated with GNP through electrostatic interaction, and characterization was carried out by Fourier-transmission infrared spectroscopy, screening electron microscopy, and transmission electron microscopy and supported by energy-dispersive X-ray spectroscopy. Antibacterial activity of the herbal extract and GNP conjugation was evaluated by disc diffusion assay.Results: Chemical and morphological characterizations of the GNP and herbal extract conjugate revealed intactness of the GNP. In disc diffusion assay, the inhibition zone formed by these compounds was measured for both microorganisms, and they were in the range of 0.6-0.9 cm for the herbal extract. When the herbal extract conjugated with GNP, the zone was between 0.8 and 1.1 cm.Conclusion: This study demonstrated the potentiality of GNP to carry the antibacterial compounds from the herbal extract.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80254350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Katagi, Jennifer Fernandes, Shivalingrao MamleDesai, M. Sujatha, A. Rekha, Girish Bolakatti
Background: The biological effects of organophosphorus (OP) compounds are connected with the irreversible inhibition of acetylcholinesterase (AChE), an important neuromediator acetylcholine (ACh) splitting enzyme in the human body at the synaptic clefts. Due to this inhibition, AChE is unable to fulfil its physiological function resulting in the accumulation of ACh, which, in turn over stimulates the parasympathetic nerve receptors, and causes fatal cholinergic crisis. Objective: The objective of the study was to synthesize a series of Schiff base oximes and to assess their evaluating for their in vitro reactivating potency against chlorpyrifos inhibited AChE. Methods: The amino group of 4-amino acetophenone exploited by treating with substituted benzaldehyde in the presence of glacial acetic acid to form Schiff base (1a-1f). The titled compounds (2a-2f) were prepared by treating Schiff base with hydroxylamine hydrochloride in the presence of alcohol. Through structural and spectral analysis, the structure of compounds was confirmed. The synthesized compounds were evaluated for their reactivation efficacy against chlorpyrifos-inhibited rat brain AChE by Ellman's method. Results: The pralidoxime (2-PAM) was potent reactivation against chlorpyrifos-inhibited AChE at the concentration tested (0.001 M). In this case, the compounds 2a (40.4%, 60 min) and 2d (37.9%, 60 min) showed promising reactivation as compared to 2-PAM (40.6%, 60min) against chlorpyrifos-inhibited AChE. Conclusion: Compounds having chloro (2a) and nitro (2d) substitution on 4th position gave good activity against chlorpyrifos-inhibited AChE. Moreover, these Schiff base oximes seem to be very promising because of their sufficient reactivation strength at lower concentration (10-3 M).
{"title":"Schiff Base Oxime Derivatives Reactivate Chlorpyrifos-induced Acetylcholinesterase Inhibition","authors":"M. Katagi, Jennifer Fernandes, Shivalingrao MamleDesai, M. Sujatha, A. Rekha, Girish Bolakatti","doi":"10.26689/itps.v2i1.499","DOIUrl":"https://doi.org/10.26689/itps.v2i1.499","url":null,"abstract":"Background: The biological effects of organophosphorus (OP) compounds are connected with the irreversible inhibition of acetylcholinesterase (AChE), an important neuromediator acetylcholine (ACh) splitting enzyme in the human body at the synaptic clefts. Due to this inhibition, AChE is unable to fulfil its physiological function resulting in the accumulation of ACh, which, in turn over stimulates the parasympathetic nerve receptors, and causes fatal cholinergic crisis. \u0000Objective: The objective of the study was to synthesize a series of Schiff base oximes and to assess their evaluating for their in vitro reactivating potency against chlorpyrifos inhibited AChE. \u0000Methods: The amino group of 4-amino acetophenone exploited by treating with substituted benzaldehyde in the presence of glacial acetic acid to form Schiff base (1a-1f). The titled compounds (2a-2f) were prepared by treating Schiff base with hydroxylamine hydrochloride in the presence of alcohol. Through structural and spectral analysis, the structure of compounds was confirmed. The synthesized compounds were evaluated for their reactivation efficacy against chlorpyrifos-inhibited rat brain AChE by Ellman's method. \u0000Results: The pralidoxime (2-PAM) was potent reactivation against chlorpyrifos-inhibited AChE at the concentration tested (0.001 M). In this case, the compounds 2a (40.4%, 60 min) and 2d (37.9%, 60 min) showed promising reactivation as compared to 2-PAM (40.6%, 60min) against chlorpyrifos-inhibited AChE. \u0000Conclusion: Compounds having chloro (2a) and nitro (2d) substitution on 4th position gave good activity against chlorpyrifos-inhibited AChE. Moreover, these Schiff base oximes seem to be very promising because of their sufficient reactivation strength at lower concentration (10-3 M).","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82422375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Zolmitriptan is an artificial tryptamine, employed for the acute cure of migraine attack with or exclusive of aura and cluster headaches. Objective: It is an attempt to develop the extended release (ER) of Zolmitriptan matrix (ZMT) tablets to treat migraine safely and effectively. Methods: All formulations were prepared with natural polymers or gums like guar gum, xanthan gum, karaya gum through direct compression method using 6mm punch. Results: Powder blend of all formulations (F1 - F12) using different ratios of the above mentioned gums (5%, 10%, 15% and 20%) were characterized with pre-compression parameters (angle of repose, bulk density, tapped density, compressibility index, hausner ratio, compatibility studies) and post-compression parameters (weight variation, thickness, friability, hardness, assay, in vitro dissolution studies). F1 - F4 formulations were prepared with gum karaya and compared with remaining gums; gum karaya shows more retardance capacity. F9 - F12 (with guar gum) formulations were unable to produce the desired release, whereas F5 - F8 formulations containing with xanthan gum exhibited more retarding effect with increasing concentration of polymer. Conclusion: All prepared formulations (F1 - F12) were characterized and F3 formulation was optimized (97.3% drug released in 8 hours). All prepared formulations (F1 - F12) showed good flow properties and release patterns. Hence, formulations of ZMT matrix tablets have a promising delivery system which will enhance bio-availability and achieve greater therapeutic efficacy.
{"title":"Formulation Development and In Vitro Characterization of Zolmitriptan Controlled Release Drug Delivery Systems","authors":"Shambhavi Pandala, V. Bakshi, R. Jadi","doi":"10.26689/ITPS.V2I1.550","DOIUrl":"https://doi.org/10.26689/ITPS.V2I1.550","url":null,"abstract":"Background: Zolmitriptan is an artificial tryptamine, employed for the acute cure of migraine attack with or exclusive of aura and cluster headaches. \u0000Objective: It is an attempt to develop the extended release (ER) of Zolmitriptan matrix (ZMT) tablets to treat migraine safely and effectively. \u0000Methods: All formulations were prepared with natural polymers or gums like guar gum, xanthan gum, karaya gum through direct compression method using 6mm punch. \u0000Results: Powder blend of all formulations (F1 - F12) using different ratios of the above mentioned gums (5%, 10%, 15% and 20%) were characterized with pre-compression parameters (angle of repose, bulk density, tapped density, compressibility index, hausner ratio, compatibility studies) and post-compression parameters (weight variation, thickness, friability, hardness, assay, in vitro dissolution studies). F1 - F4 formulations were prepared with gum karaya and compared with remaining gums; gum karaya shows more retardance capacity. F9 - F12 (with guar gum) formulations were unable to produce the desired release, whereas F5 - F8 formulations containing with xanthan gum exhibited more retarding effect with increasing concentration of polymer. \u0000Conclusion: All prepared formulations (F1 - F12) were characterized and F3 formulation was optimized (97.3% drug released in 8 hours). All prepared formulations (F1 - F12) showed good flow properties and release patterns. Hence, formulations of ZMT matrix tablets have a promising delivery system which will enhance bio-availability and achieve greater therapeutic efficacy.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86170394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Human health poses severe problems caused by various factors; which includes disease-causing agents that have been raised due to the emergence and re-emergence of diseases. In the past, different classes of diseases were reported and they are infectious, non-infectious and contagious created a threat to the public health and economy. To overcome these hurdles, theranostics, a fast-growing discipline has become a tool with the advancements of therapeutics and medical diagnosis. Achievement with theranostics was driven by different input from various angles of medical researches. These approaches were attested with the novel creations of a complete platform for the clinic analysis and therapy. Eventually, the involvement of all levels of stakeholders and their acquired knowledge sharing were expanded to the theranostics approaches. On the other hand, Pharmacological sciences generate the remedies to a wide range of diseases with the demonstration of different pharmacological products. This discipline delineates the mode of drug action, including natural and man-made compounds that show the influence on the human tissues and organs.
{"title":"A Foreword from the Editor","authors":"S. Gopinath","doi":"10.26689/ITPS.V1I1.512","DOIUrl":"https://doi.org/10.26689/ITPS.V1I1.512","url":null,"abstract":"Human health poses severe problems caused by various factors; which includes disease-causing agents that have been raised due to the emergence and re-emergence of diseases. In the past, different classes of diseases were reported and they are infectious, non-infectious and contagious created a threat to the public health and economy. To overcome these hurdles, theranostics, a fast-growing discipline has become a tool with the advancements of therapeutics and medical diagnosis. Achievement with theranostics was driven by different input from various angles of medical researches. These approaches were attested with the novel creations of a complete platform for the clinic analysis and therapy. Eventually, the involvement of all levels of stakeholders and their acquired knowledge sharing were expanded to the theranostics approaches. On the other hand, Pharmacological sciences generate the remedies to a wide range of diseases with the demonstration of different pharmacological products. This discipline delineates the mode of drug action, including natural and man-made compounds that show the influence on the human tissues and organs.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80546473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The exposure and inhalation of acrylamide (ACR) are not safe to the human health leading to the potential neurotoxicity. ACR is widely used in biochemical techniques and highly occurs in processing foods such as potato chips prepared at high temperatures. ACR is formed from reducing sugars and asparagine through the Maillard reaction. It exerts various harmful and toxic effects such as neurotoxicity both in humans and animal studies. The extensive damage of synaptic proteins, the formation of ACR-DNA adducts, degeneration of motor neurons, neurofilament reduction, are the most common neurological symptoms. The main metabolite of ACR metabolism is glycidamide, and it causes harmful effects as same as ACR. The main purpose of this study is to analyze the neurotoxic effects of ACR on various regions of the brain and its different mechanistic pathways that are involved in ACR neurotoxicity. The consumption of ACR-containing foods and its exposure are reduced by the human, leading to the reduction of toxic effects associated with ACR.
{"title":"Review on Chronic Exposure of Acrylamide Causes a Neurotoxicity Risk","authors":"N. Maddu, S. F. Begum","doi":"10.26689/ITPS.V1I1.416","DOIUrl":"https://doi.org/10.26689/ITPS.V1I1.416","url":null,"abstract":"The exposure and inhalation of acrylamide (ACR) are not safe to the human health leading to the potential neurotoxicity. ACR is widely used in biochemical techniques and highly occurs in processing foods such as potato chips prepared at high temperatures. ACR is formed from reducing sugars and asparagine through the Maillard reaction. It exerts various harmful and toxic effects such as neurotoxicity both in humans and animal studies. The extensive damage of synaptic proteins, the formation of ACR-DNA adducts, degeneration of motor neurons, neurofilament reduction, are the most common neurological symptoms. The main metabolite of ACR metabolism is glycidamide, and it causes harmful effects as same as ACR. The main purpose of this study is to analyze the neurotoxic effects of ACR on various regions of the brain and its different mechanistic pathways that are involved in ACR neurotoxicity. The consumption of ACR-containing foods and its exposure are reduced by the human, leading to the reduction of toxic effects associated with ACR.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90536570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aptamer: A Versatile Probe in Medical Diagnosis","authors":"T. LakshmiPriya, S. Gopinath","doi":"10.26689/ITPS.V1I1.511","DOIUrl":"https://doi.org/10.26689/ITPS.V1I1.511","url":null,"abstract":"<jats:p />","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73162316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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