{"title":"Real-World Treatment Patterns in AERD: An Analysis of ATAD, Biologics, and Combination Therapy","authors":"Nitish Kumar, Tyson Pace, Pedro Lança Gomes, Michael J. Marino, Amar Miglani, Devyani Lal","doi":"10.1002/alr.70072","DOIUrl":"10.1002/alr.70072","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>Contemporary aspirin exacerbated respiratory disorder (AERD) therapy commonly includes aspirin desensitization (55%) and biologics (48%).</li>\u0000 \u0000 <li>Aspirin desensitization therapy has higher discontinuation rates than biologics.</li>\u0000 \u0000 <li>Patients receiving biologics are younger, and ∼25% of the patients switch to other agents.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 1","pages":"99-101"},"PeriodicalIF":6.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David K. Lerner, Iulia Tapescu, Isha Thapar, Alan D. Workman, Yasser Almansour, Derek H. Liu, Margaret B. Mitchell, Saawan Patel, John R. Craig, Jennifer E. Douglas, Jacob Eide, Edward C. Kuan, James N. Palmer, Nithin D. Adappa, Michael A. Kohanski
<p>Beyond the most common types of benign sinonasal tumors, such as osteoma or papilloma, there is a range of rarer benign neoplasms that are less well-understood in terms of behavior and optimal management [<span>1</span>]. These tumors may arise from mesenchymal, vascular, or neural, among other tissues, and are heterogeneous in pathology within categories [<span>2</span>]. The literature currently lacks comprehensive guidance on management and post-operative surveillance for these rare tumors. In this multi-institutional study, we report our outcomes following endoscopic gross total resection (GTR) of rare benign sinonasal tumors and offer guidance on optimal surveillance strategies.</p><p>A retrospective chart review was conducted of patients with benign sinonasal tumors undergoing GTR at the University of Pennsylvania, Massachusetts Eye and Ear, University of California-Irvine, and Henry Ford Health System from January 2010 to January 2025. Patients with malignancy, inverted papilloma, osteoma, or juvenile angiofibroma were excluded. Only patients undergoing GTR via the endoscopic approach with at least 6 months of postoperative follow-up were included.</p><p>Basic demographic information and relevant clinical features were collected, including pathology, recurrence rate, frequency of surveillance visits, and modality of post-operative surveillance—endoscopy, magnetic resonance imaging (MRI), or computed tomography (CT). Surveillance visits were defined as post-operative visits, excluding debridements or “sick visits.” Tumors were categorized according to the 2024 International Consensus Statement on Sinonasal Tumors [<span>1</span>] recommendations and WHO classification [<span>2</span>].</p><p>A total of 47 patients were included in the analysis, with tumors categorized as mesenchymal (<i>n</i> = 20, 42.5%), vascular (<i>n</i> = 17, 36.2%), or neural (<i>n</i> = 10, 21.3%). Mesenchymal tumors included solitary fibrous tumor (SFT; <i>n</i> = 8), angioleiomyoma (<i>n</i> = 3), pleomorphic adenoma (<i>n</i> = 3), fibrous dysplasia (<i>n</i> = 2), inflammatory myofibroblastic tumor (<i>n</i> = 1), ossifying fibroma (<i>n</i> = 1), chondroma (<i>n</i> = 1), and lipoma (<i>n</i> = 1). Vascular tumors comprised lobular capillary hemangioma (LCH; <i>n</i> = 8), hemangioma unspecified (<i>n</i> = 3), cavernous hemangioma (<i>n</i> = 3), intraosseous hemangioma (<i>n</i> = 2), and arteriovenous malformation (AVM; <i>n</i> = 1). Neural tumors consisted exclusively of schwannomas.</p><p>Mean follow-up duration was 24.1 months with a median of 17.8 months (Table 1). By category, the mean follow-up was 26.3 months for mesenchymal, 18.0 months for vascular, and 30.2 months for neural tumors. The average number of postoperative visits in the first year was 2.7, with similar means across categories: mesenchymal (2.6), vascular (2.9), and neural (2.6). In the second year, the average number of visits was 1.1 overall, with little variation across tumor types
{"title":"Post-Operative Surveillance After Resection of Uncommon Benign Sinonasal Tumors: A Multi-Institutional Review","authors":"David K. Lerner, Iulia Tapescu, Isha Thapar, Alan D. Workman, Yasser Almansour, Derek H. Liu, Margaret B. Mitchell, Saawan Patel, John R. Craig, Jennifer E. Douglas, Jacob Eide, Edward C. Kuan, James N. Palmer, Nithin D. Adappa, Michael A. Kohanski","doi":"10.1002/alr.70046","DOIUrl":"10.1002/alr.70046","url":null,"abstract":"<p>Beyond the most common types of benign sinonasal tumors, such as osteoma or papilloma, there is a range of rarer benign neoplasms that are less well-understood in terms of behavior and optimal management [<span>1</span>]. These tumors may arise from mesenchymal, vascular, or neural, among other tissues, and are heterogeneous in pathology within categories [<span>2</span>]. The literature currently lacks comprehensive guidance on management and post-operative surveillance for these rare tumors. In this multi-institutional study, we report our outcomes following endoscopic gross total resection (GTR) of rare benign sinonasal tumors and offer guidance on optimal surveillance strategies.</p><p>A retrospective chart review was conducted of patients with benign sinonasal tumors undergoing GTR at the University of Pennsylvania, Massachusetts Eye and Ear, University of California-Irvine, and Henry Ford Health System from January 2010 to January 2025. Patients with malignancy, inverted papilloma, osteoma, or juvenile angiofibroma were excluded. Only patients undergoing GTR via the endoscopic approach with at least 6 months of postoperative follow-up were included.</p><p>Basic demographic information and relevant clinical features were collected, including pathology, recurrence rate, frequency of surveillance visits, and modality of post-operative surveillance—endoscopy, magnetic resonance imaging (MRI), or computed tomography (CT). Surveillance visits were defined as post-operative visits, excluding debridements or “sick visits.” Tumors were categorized according to the 2024 International Consensus Statement on Sinonasal Tumors [<span>1</span>] recommendations and WHO classification [<span>2</span>].</p><p>A total of 47 patients were included in the analysis, with tumors categorized as mesenchymal (<i>n</i> = 20, 42.5%), vascular (<i>n</i> = 17, 36.2%), or neural (<i>n</i> = 10, 21.3%). Mesenchymal tumors included solitary fibrous tumor (SFT; <i>n</i> = 8), angioleiomyoma (<i>n</i> = 3), pleomorphic adenoma (<i>n</i> = 3), fibrous dysplasia (<i>n</i> = 2), inflammatory myofibroblastic tumor (<i>n</i> = 1), ossifying fibroma (<i>n</i> = 1), chondroma (<i>n</i> = 1), and lipoma (<i>n</i> = 1). Vascular tumors comprised lobular capillary hemangioma (LCH; <i>n</i> = 8), hemangioma unspecified (<i>n</i> = 3), cavernous hemangioma (<i>n</i> = 3), intraosseous hemangioma (<i>n</i> = 2), and arteriovenous malformation (AVM; <i>n</i> = 1). Neural tumors consisted exclusively of schwannomas.</p><p>Mean follow-up duration was 24.1 months with a median of 17.8 months (Table 1). By category, the mean follow-up was 26.3 months for mesenchymal, 18.0 months for vascular, and 30.2 months for neural tumors. The average number of postoperative visits in the first year was 2.7, with similar means across categories: mesenchymal (2.6), vascular (2.9), and neural (2.6). In the second year, the average number of visits was 1.1 overall, with little variation across tumor types","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 12","pages":"1433-1435"},"PeriodicalIF":6.8,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alr.70046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nitish Kumar, Gaurav Jategaonkar, Stephen F. Bansberg, Michael J. Marino, Devyani Lal, Amar Miglani
{"title":"Saddle Nose Deformity in Granulomatosis With Polyangiitis: Clinical and Radiologic Predictors From a Multicenter Cohort","authors":"Nitish Kumar, Gaurav Jategaonkar, Stephen F. Bansberg, Michael J. Marino, Devyani Lal, Amar Miglani","doi":"10.1002/alr.70065","DOIUrl":"10.1002/alr.70065","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 1","pages":"96-98"},"PeriodicalIF":6.8,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Re: Letter to the Editor Regarding “Uncovering Key Features for Predicting Comorbid Chronic Eosinophilic Pneumonia in Chronic Rhinosinusitis Via Machine Learning”","authors":"Masaaki Ishikawa, Zhiqian Jiang, Canh Hao Nguyen, Hiroatsu Hatsukawa, Tomoyuki Hirai, Hirotaka Matsumoto, Emiko Saito, Kouya Okazaki, Kazuo Endo, Satoru Terada, Hiroshi Mamitsuka","doi":"10.1002/alr.70062","DOIUrl":"10.1002/alr.70062","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 12","pages":"1453-1454"},"PeriodicalIF":6.8,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145477040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John Dewey, Ryan S. Ziltzer, Hassan Ramadan, Chadi A. Makary
Key Points
Patients with olfactory dysfunction are at an increased risk of trigeminal nerve dysfunction.
This association is stronger in patients with parosmia.
嗅觉功能障碍患者发生三叉神经功能障碍的风险增加。这种关联在失语症患者中更为明显。
{"title":"Olfactory Dysfunction Is Associated With Increased Risk of Trigeminal Dysfunction and Migraine: A Population-Based Study","authors":"John Dewey, Ryan S. Ziltzer, Hassan Ramadan, Chadi A. Makary","doi":"10.1002/alr.70064","DOIUrl":"10.1002/alr.70064","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>Patients with olfactory dysfunction are at an increased risk of trigeminal nerve dysfunction.</li>\u0000 \u0000 <li>This association is stronger in patients with parosmia.</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 12","pages":"1439-1441"},"PeriodicalIF":6.8,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elke Vandewalle, Els De Schryver, Lien Calus, Manon Blauwblomme, Pauline Janssen, Ellen Ketelaere, Sharon Van Nevel, Anne-Sophie Eeckels, Natalie De Ruyck, Gabriele Holtappels, Lara Derycke, Claus Bachert, Stijn Vanhee, Philippe Gevaert, Thibaut Van Zele
Background
Chronic rhinosinusitis (CRS) may require endoscopic sinus surgery (ESS) as a complement to medical therapies. Type 2 dominant inflammation underlies nasal polyposis (CRSwNP), and is characterized by eosinophilic inflammation, poor therapeutic response, and high recurrence risk. Type 2 inflammation was defined as eosinophilic CRS (ECRS) based on clinical presentation and laboratory findings. Unfavorable wound healing, associated with elevated levels of matrix metalloproteinase 9 (MMP-9), can lead to failure of ESS. Doxycycline with its antibiotic, anti-inflammatory, and anti-protease (including MMP-9) properties may improve postoperative healing.
Materials and Methods
Thirty-three adult CRS patients scheduled for ESS were randomly assigned to receive either doxycycline or placebo for 56 days postoperative and were followed up until 48 weeks post-ESS. Postoperative wound healing was assessed endoscopically. Nasal secretions, serum, and patient-reported outcome measures were collected throughout the study. Nasal secretions were analyzed to monitor local myeloperoxidase (MPO), MMP-9, eosinophilic cationic protein (ECP), and IgE levels from baseline until 48 weeks post-ESS. Proteomics analysis, using LC-MS/MS, of nasal secretions was performed at baseline, 2- and 8-weeks post-ESS to investigate wound healing mechanisms.
Results
Postoperative doxycycline significantly improved wound healing quality in patients with CRSwNP or ECRS. Increased local MMP-9, neutrophilic (MPO), and eosinophilic (ECP) inflammation post-ESS was dampened by doxycycline. Wound healing and extracellular matrix remodeling processes were upregulated by doxycycline treatment. In contrast, the placebo group showed increased neutrophilic inflammation and delayed healing.
Conclusions
Postoperative doxycycline therapy facilitated wound healing in CRSwNP and ECRS patients and suppressed local mucosal inflammation.
{"title":"Mechanisms and Kinetics of Wound Healing in Chronic Rhinosinusitis Patients After Complete Sinus Surgery and Its Improvement by Doxycycline Therapy","authors":"Elke Vandewalle, Els De Schryver, Lien Calus, Manon Blauwblomme, Pauline Janssen, Ellen Ketelaere, Sharon Van Nevel, Anne-Sophie Eeckels, Natalie De Ruyck, Gabriele Holtappels, Lara Derycke, Claus Bachert, Stijn Vanhee, Philippe Gevaert, Thibaut Van Zele","doi":"10.1002/alr.70061","DOIUrl":"10.1002/alr.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic rhinosinusitis (CRS) may require endoscopic sinus surgery (ESS) as a complement to medical therapies. Type 2 dominant inflammation underlies nasal polyposis (CRSwNP), and is characterized by eosinophilic inflammation, poor therapeutic response, and high recurrence risk. Type 2 inflammation was defined as eosinophilic CRS (ECRS) based on clinical presentation and laboratory findings. Unfavorable wound healing, associated with elevated levels of matrix metalloproteinase 9 (MMP-9), can lead to failure of ESS. Doxycycline with its antibiotic, anti-inflammatory, and anti-protease (including MMP-9) properties may improve postoperative healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty-three adult CRS patients scheduled for ESS were randomly assigned to receive either doxycycline or placebo for 56 days postoperative and were followed up until 48 weeks post-ESS. Postoperative wound healing was assessed endoscopically. Nasal secretions, serum, and patient-reported outcome measures were collected throughout the study. Nasal secretions were analyzed to monitor local myeloperoxidase (MPO), MMP-9, eosinophilic cationic protein (ECP), and IgE levels from baseline until 48 weeks post-ESS. Proteomics analysis, using LC-MS/MS, of nasal secretions was performed at baseline, 2- and 8-weeks post-ESS to investigate wound healing mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Postoperative doxycycline significantly improved wound healing quality in patients with CRSwNP or ECRS. Increased local MMP-9, neutrophilic (MPO), and eosinophilic (ECP) inflammation post-ESS was dampened by doxycycline. Wound healing and extracellular matrix remodeling processes were upregulated by doxycycline treatment. In contrast, the placebo group showed increased neutrophilic inflammation and delayed healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Postoperative doxycycline therapy facilitated wound healing in CRSwNP and ECRS patients and suppressed local mucosal inflammation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 2","pages":"183-195"},"PeriodicalIF":6.8,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elevated immunoglobulin (Ig) E has been frequently observed in eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). However, the relationship between IgE levels and immune microenvironment remains poorly understood. This study aimed to characterize the transcriptomic and immunologic profiles associated with different IgE levels in eCRSwNP, and to explore their potential clinical and biological significance.
Methods
We enrolled 30 patients with eCRSwNP and stratified them into IgE-high (tissue total IgE ≥ 34.55 kU/L and serum total IgE ≥ 100 kU/L, n = 18) and IgE-low (below both thresholds, n = 12) groups. Healthy nasal mucosa from 10 control subjects was included. Bulk RNA sequencing, gene ontology (GO), KEGG pathway analysis, and immunohistochemistry were performed to characterize IgE-associated transcriptional and protein expression profiles in nasal polyp tissues.
Results
Compared with controls, IgE-high patients exhibited higher tissue-specific IgE levels against aeroallergens, more severe clinical manifestations, and greater asthma comorbidity. Transcriptomic profiling revealed distinct gene expression patterns between eCRSwNP and healthy mucosa, with enrichment of T2 inflammation markers (CCL13, POSTN, IL5, IGHG4, and IGHE). IgE-high polyps demonstrated mucus hypersecretion and increased antimicrobial peptide expression (ITLN1, LTF, LYZ), alongside downregulated ciliary function–related genes. Immunohistochemistry validated increased IgE, IgG4, CD79a⁺ B cells and reduced FOXJ1⁺ ciliated cells in IgE-high tissues, consistent with the transcriptomic findings.
Conclusions
Tissue IgE levels delineate clinically and transcriptionally distinct eCRSwNP endotypes. IgE-high nasal polyps demonstrated epithelial barrier dysfunction, mucus overproduction, and antimicrobial peptide activation, highlighting the potential of IgE-based stratification to guide personalized treatment strategies in eCRSwNP.
{"title":"Transcriptomic Profiling Reveals Differences in Mucosal Defense and Ciliary Gene Expression in Eosinophilic Nasal Polyps Stratified by IgE Levels","authors":"Jinbo Han, Yuzhuo Liu, Weiqing Wang, Lei Wang, Yujie Chen, Zhenzhen Zhu, Wei Lv","doi":"10.1002/alr.70048","DOIUrl":"10.1002/alr.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Elevated immunoglobulin (Ig) E has been frequently observed in eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). However, the relationship between IgE levels and immune microenvironment remains poorly understood. This study aimed to characterize the transcriptomic and immunologic profiles associated with different IgE levels in eCRSwNP, and to explore their potential clinical and biological significance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We enrolled 30 patients with eCRSwNP and stratified them into IgE-high (tissue total IgE ≥ 34.55 kU/L and serum total IgE ≥ 100 kU/L, <i>n</i> = 18) and IgE-low (below both thresholds, <i>n</i> = 12) groups. Healthy nasal mucosa from 10 control subjects was included. Bulk RNA sequencing, gene ontology (GO), KEGG pathway analysis, and immunohistochemistry were performed to characterize IgE-associated transcriptional and protein expression profiles in nasal polyp tissues.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with controls, IgE-high patients exhibited higher tissue-specific IgE levels against aeroallergens, more severe clinical manifestations, and greater asthma comorbidity. Transcriptomic profiling revealed distinct gene expression patterns between eCRSwNP and healthy mucosa, with enrichment of T2 inflammation markers (CCL13, POSTN, IL5, IGHG4, and IGHE). IgE-high polyps demonstrated mucus hypersecretion and increased antimicrobial peptide expression (ITLN1, LTF, LYZ), alongside downregulated ciliary function–related genes. Immunohistochemistry validated increased IgE, IgG4, CD79a⁺ B cells and reduced FOXJ1⁺ ciliated cells in IgE-high tissues, consistent with the transcriptomic findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Tissue IgE levels delineate clinically and transcriptionally distinct eCRSwNP endotypes. IgE-high nasal polyps demonstrated epithelial barrier dysfunction, mucus overproduction, and antimicrobial peptide activation, highlighting the potential of IgE-based stratification to guide personalized treatment strategies in eCRSwNP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"16 2","pages":"170-182"},"PeriodicalIF":6.8,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correspondence Regarding “Electrical Stimulation of Trigeminal Nerve at the Anterior Nasal Septum in Healthy Individuals and Patients With Olfactory Dysfunction”","authors":"Hyun Jin Min","doi":"10.1002/alr.70052","DOIUrl":"10.1002/alr.70052","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 12","pages":"1444-1445"},"PeriodicalIF":6.8,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lirit Levi, Vivek Mohan, Yifei Ma, Christoforos Meliadis, Paramesh Gopi, Jayakar V. Nayak, Bryant Lin, Peter H. Hwang, Jacob Johnson, Kari Nadeau, Michael Blaiss, Trisha Saha Ray
Key Points
A wearable headband treats nasal congestion using acoustic resonance and AI-estimated anatomy.
Individuals with higher nasal depth-to-height ratio used acoustic therapy more often.
Depth-to-height ratio may be an anatomical marker for increased nasal congestion risk
{"title":"The Influence of Nasal Cavity Dimensions on Frequency of Treatment for Rhinitis Symptoms","authors":"Lirit Levi, Vivek Mohan, Yifei Ma, Christoforos Meliadis, Paramesh Gopi, Jayakar V. Nayak, Bryant Lin, Peter H. Hwang, Jacob Johnson, Kari Nadeau, Michael Blaiss, Trisha Saha Ray","doi":"10.1002/alr.70060","DOIUrl":"10.1002/alr.70060","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Points</h3>\u0000 \u0000 <div>\u0000 <ul>\u0000 \u0000 <li>A wearable headband treats nasal congestion using acoustic resonance and AI-estimated anatomy.</li>\u0000 \u0000 <li>Individuals with higher nasal depth-to-height ratio used acoustic therapy more often.</li>\u0000 \u0000 <li>Depth-to-height ratio may be an anatomical marker for increased nasal congestion risk</li>\u0000 </ul>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 12","pages":"1436-1438"},"PeriodicalIF":6.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145389158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor Regarding “Uncovering Key Features for Predicting Comorbid Chronic Eosinophilic Pneumonia in Chronic Rhinosinusitis via Machine Learning”","authors":"Wenjun Li, Fanghong Hong","doi":"10.1002/alr.70063","DOIUrl":"10.1002/alr.70063","url":null,"abstract":"","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":"15 12","pages":"1442-1443"},"PeriodicalIF":6.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145389163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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