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Efficacy and safety of Vicia faba L. extract compared with levodopa in management of Parkinson’s disease and an in‐silico phytomedicine analysis 蚕豆提取物与左旋多巴治疗帕金森病的疗效和安全性比较及硅植物医学分析
Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-10-03 DOI: 10.47552/ijam.v14i3.3481
Karim Nikkhah, Ali Shoeibi, Fariborz Rezaeitalab, Samira Aminzadeh, Hussein Sharara, Mahdi Abbas-Mohammadi, Mohammad Al-attar, Mohammadeza Akbari, Fereydun Moradi, Hasan Rakhshandeh, Morteza Saeidi
Background: Parkinson’s disease is a chronic degenerative disease of the central nervous system, presently lacks an effective therapy for its complex pathogenesis. Agents containing Levodopa can alleviate its symptoms. Hypothesis Vicia faba L. (Fava bean) extract may prove a useful antiparkinsonian agent similar to Levodopa. Methods: Thirty patients with Parkinson’s disease, entered into this cross over clinical study. In the first step, each participant received V. faba L. extract containing 106.5 mg of Levodopa. After a wash out period of 7 days, the patients entered the second step during which they received conventional treatment with Levodopa-C tablets. Blood Levodopa were measured 4 hours and 8 hours after each administration. The Movement Disorder Society-Unified Parkinson’s Disease Rating Scale was employed to measure the therapeutic effects in each step. Additionally, a docking analysis was performed to distinguish the chemical constituents of the plant and six key mediators actively involved in Parkinson disease. Results: The fava bean extract significantly alleviate all studied end points except for tremor at rest and freezing. Wilcoxon Signed Ranks Test showed that there was not a significant difference between rigidity, rising chair, gait and bradykinesia. Docking results of the herb components and standard ligands, indicating that the antiparkinsonian activity of V. faba could presumably be related to many phytochemicals. Conclusion: This study showed a beneficial effect of V. faba L. similar to Levodopa-C. and better compliance due to lower adverse events.
背景:帕金森病是一种慢性中枢神经系统退行性疾病,由于其复杂的发病机制,目前缺乏有效的治疗方法。含有左旋多巴的药剂可以缓解其症状。假设蚕豆提取物可能被证明是一种有用的抗帕金森药物,类似于左旋多巴。方法:对30例帕金森病患者进行交叉临床研究。在第一步中,每个参与者接受含有106.5 mg左旋多巴的蚕豆提取物。在7天的洗脱期后,患者进入第二步,在此期间他们接受左旋多巴- c片的常规治疗。分别于给药后4小时和8小时测定左旋多巴血药浓度。采用运动障碍学会-统一帕金森病评定量表衡量各步骤的治疗效果。此外,还进行了对接分析,以区分该植物的化学成分和六种积极参与帕金森病的关键介质。结果:蚕豆提取物能显著缓解除静止和冻结时震颤外的所有终点。Wilcoxon sign rank检验结果显示,刚性、立椅、步态和运动迟缓之间无显著差异。草本成分与标准配体的对接结果表明,蚕豆豆的抗帕金森病活性可能与多种植物化学物质有关。结论:本研究显示蚕豆菌具有类似左旋多巴c的有益作用。由于不良事件减少,依从性更好。
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引用次数: 0
Screening of Phytoresources from the Romanian Flora with medical applications against Covid - Review 罗马尼亚植物区系中抗新冠肺炎医学应用植物资源筛选综述
Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-10-03 DOI: 10.47552/ijam.v14i3.3629
Rodica Catana, Mirela M. Moldoveanu, Raluca A. Mihai, Anca Botezatu, Adrian Albulescu, Anush Kosakyan, Larisa Florescu
Plants are an important means of combating numerous harmful influences on humans (microorganisms, viruses, fungi, etc.) and have always been used to treat various diseases. In the context of the Covid pandemic, interest in the use of plants has increased. Great importance has been given to screening plants' potential against Covid (antiviral, anti-inflammatory, immunostimulatory, and antioxidant). According to recent research, many of the plant species used against Covid are of Asian origin. In this review, we aim to discuss the plant species with these medicinal potentials with a focus on Romanian flora. We have listed a total of 50 Phyto-resources from Romanian flora with different potentials: 26 containing the confirmed anti-covid compounds, and 9 species having antiviral, anti-inflammatory, immunostimulant, and antioxidant potentials.
植物是对抗许多对人类有害影响(微生物、病毒、真菌等)的重要手段,一直被用于治疗各种疾病。在2019冠状病毒病大流行的背景下,人们对利用植物的兴趣有所增加。筛选植物抗新冠病毒的潜力(抗病毒、抗炎、免疫刺激和抗氧化)受到高度重视。根据最近的研究,许多用于抗新冠病毒的植物物种都来自亚洲。在这篇综述中,我们的目的是讨论具有这些药用潜力的植物物种,重点是罗马尼亚植物区系。我们列出了来自罗马尼亚植物群的50种具有不同潜力的植物资源:26种含有已证实的抗covid - 19化合物,9种具有抗病毒、抗炎、免疫刺激和抗氧化潜力。
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引用次数: 0
In vitro antioxidant and nephroprotective properties of Polyalthia longifolia: A traditional medicinal plant 传统药用植物长叶多糖的体外抗氧化和肾脏保护作用
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.3529
D. Bisht, Deena Prakash, D. Yadav, A. Shakya, Ramesh Kumar, S. Shrivastava, S. Shukla
Polyalthia longifolia (Sonn.) Thwaites is a traditional medicinal plant with diverse medicinal properties including kidney protection. The present investigation was aimed to assess the phytochemical content, antioxidant activity and evaluate nephroprotective activity of Polyalthia longifolia (PL) 70% ethanolic leaf extract against cisplatin and gentamicin-induced toxicity on HEK293 cell line. Phytochemical analysis confirmed the presence of flavonoids, reducing sugars, tannins, coumarin, saponins, alkaloids, and glycosides, as well as the abundant total phenolic and total flavonoid content in the PL leaf extract. The extract exhibited significant free radical scavenging activity (p<0.001) in ABTS (IC50 224 μg/mL), DPPH (IC50 150.1 μg/mL) and H2O2 (IC50 271.1 μg/mL) assays. In vitro MTT assay validated remarkable cytoprotective activity (p<0.001) of PL leaf extract at three concentrations (125 μg/mL, 250 μg/mL, 500 μg/mL) against cisplatin and gentamicin treated HEK293 cell line in dose dependent manner with 70% cell viability (IC50 312.6 µg/mL) and 72% cell viability (IC50 307.3 µg/mL), respectively, at PL dose 500 μg/mL. The cytotoxicity assay also confirmed no adverse effect of PL leaf extract on cell viability in the HEK293 and considered as nontoxic when compared with normal control group. The present study revealed that Polyalthia longifolia leaf extract has remarkable antioxidant activity and nephroprotective properties against cisplatin and gentamicin induced nephrotoxicity in in vitro model which might be due the presence of free radical scavenging phytochemicals. 
长叶多糖(Polyathia longifolia,Sonn.)Thwaites是一种传统药用植物,具有多种药用特性,包括肾脏保护。本研究旨在评估长叶多糖(PL)70%乙醇叶提取物对顺铂和庆大霉素诱导的HEK293细胞毒性的植物化学成分、抗氧化活性和肾保护活性。植物化学分析证实了PL叶提取物中存在黄酮、还原糖、单宁、香豆素、皂苷、生物碱和糖苷,以及丰富的总酚和总黄酮含量。提取物在ABTS(IC50 224μg/mL)、DPPH(IC50 150.1μg/mL)和H2O2(IC50 271.1μg/mL)测定中表现出显著的自由基清除活性(p<0.001)。体外MTT法验证了三种浓度(125μg/mL、250μg/mL和500μg/mL)的PL叶提取物对顺铂和庆大霉素处理的HEK293细胞系具有显著的细胞保护活性(p<0.001),在PL剂量为500μg/mL。细胞毒性测定也证实PL叶提取物对HEK293中的细胞活力没有不良影响,并且与正常对照组相比被认为是无毒的。本研究表明,在体外模型中,长叶多糖叶提取物对顺铂和庆大霉素诱导的肾毒性具有显著的抗氧化活性和肾保护作用,这可能是由于存在清除自由基的植物化学物质。
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引用次数: 0
Validation of hospital environmental disinfection efficiency of herbal fumigants 中药熏蒸剂对医院环境消毒效果的验证
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.3547
S. Tavhare, Karan Lakhani
Background: Healthcare associated infections includes infestation by bacteria, viruses and fungi. As per WHO estimates, approximately 15% of all hospitalized patients suffer from these nosocomial infections caused by these micro-organisms. Outbreaks of such infections increases the use of antibiotics, vitamins and immonomodulator medicines. During ancient times, to prevent spread of infections; fumigation with herbs was a practice and it is still seen continued. Material & methods: Good quality herbal fumigants like Guggulu gum-resin, turmeric powder, spikenard rhizome, white mustard fruits, caraway fruits, camphor resins and cow’s ghee were used for fumigation of various hospital rooms like out-patient department room, dental clinic, gynecological procedure room, physiotherapy and operation theatre of Community Healthcare Center, Sarsa. Swabs from these units were tested for bacterial and fungal load before and after experiment by using culture media’s like nutrient broth and potato dextrose agar respectively. Results: The bacteria culture reported organisms namely Bacilus subtilis, Bacilus megaterium, Staphylococcus aureus, Micrococcus luteus and fungi like Aspergillus niger, mucor and rhizophus. After 30 minutes of fumigation procedure, significant reduction in bacterial colonies was found in gynecological procedure room, dental clinic, OPD and physiotherapy room while statistically non-significant results were observed in operation theatre. Two hours after fumigation, statistically significant result was observed in bacterial count in all studied units except operation theatre while fungal colonies reduction was achieved in all studied units. Conclusion: Fumigation shall be encouraged in hospital units like out patients department, wards and minor procedure rooms but may not be perfectly suitable for operative theatres always. The study encourages daily herbal fumigation of home and surroundings for hygienic and pleasant environment.
背景:医疗保健相关感染包括细菌、病毒和真菌的感染。据世卫组织估计,所有住院患者中约有15%患有由这些微生物引起的院内感染。这类感染的爆发增加了抗生素、维生素和免疫调节剂药物的使用。在古代,防止传染病的传播;用草药熏蒸是一种做法,现在仍在继续。材料与方法:采用谷谷胶树脂、姜黄粉、香根、白芥子、葛缕子、樟脑树脂、牛油等优质草本熏蒸剂,对Sarsa社区卫生中心门诊部、牙科诊所、妇科手术室、理疗、手术室等各病房进行熏蒸。实验前后分别用营养肉汤和马铃薯葡萄糖琼脂等培养基对各单位拭子进行细菌和真菌负荷检测。结果:细菌培养有枯草芽孢杆菌、巨型芽孢杆菌、金黄色葡萄球菌、黄体微球菌和黑曲霉、毛霉、根霉等真菌。熏蒸30分钟后,妇科手术室、牙科诊所、门诊和理疗室细菌菌落数量明显减少,而手术室细菌菌落数量无统计学意义。熏蒸2 h后,除手术室外,所有研究单位细菌计数均有统计学意义,真菌菌落均有所减少。结论:在医院门诊部、病房、小手术室等单位应提倡熏蒸,但不一定完全适用于手术室。该研究鼓励每天对家庭和周围环境进行草药熏蒸,以营造卫生和宜人的环境。
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引用次数: 0
Evaluation & Comparison of Nicotine quantification in smokeless tobacco products 无烟烟草制品中尼古丁定量的评价与比较
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.3632
G. Parmar, Ashish P. Shah, C. Aundhia, J. Chudasama
Introduction: Smokeless tobacco products (STPS) represent a significant health risk and have been associated with oral and pancreatic cancers, oral lesions, coronary artery and peripheral vascular disease and adverse pregnancy outcomes. So, the aim of the present study is to perform quantitative determination of nicotine, the main alkaloid of smokeless product (Gutkha) available in Vadodara, Gujarat. Method: Collection of sample was done from local tobacco selling shopkeeper from Vadodara i.e. vimal, RMD, pan vilas, rajnigandha and raag. All the samples included in the study the same products available everywhere in Gujarat. The quantification of nicotine was done by High Performance Thin Layer Chromatography (HPTLC) using the mobile phase toluene: ethyl acetate: Diethylamine (6:4:0.5). Spectrodensitometric measurement was carried out at absorption maximum 254 nm. Results:  Five different smokeless tobacco samples were estimated using HPTLC method. Nicotine content was found to be 2.45% in Vimal, 3.11% in RMD, 2.60%- Pan Vilas, 3.06%- Rajigandha,3.32%- Raag. Conclusion: A considerable variation of nicotine content was found among the five investigated smokeless tobacco product where sample raag revealed the highest amount of nicotine than the other samples. The nicotine concentration of commercially available chewing tobacco products was found to be much lower than that of the smoking form of tobacco, but the higher average daily consumption made it comparable to the smoking form.
引言:无烟烟草制品(STPS)是一种重大的健康风险,与口腔癌和胰腺癌、口腔病变、冠状动脉和外周血管疾病以及不良妊娠结局有关。因此,本研究的目的是对古吉拉特邦瓦都达拉市无烟产品(Gutkha)的主要生物碱尼古丁进行定量测定。方法:从Vadodara的当地烟草销售店主那里采集样本,即vimal、RMD、pan vilas、rajnigandha和raag。研究中包括的所有样本都是古吉拉特邦随处可见的相同产品。用高效薄层色谱法(HPTLC)对尼古丁进行定量,流动相为甲苯:乙酸乙酯:二乙胺(6:4:0.5),最大吸收波长为254nm。结果:采用高效薄层色谱法对5种不同类型的无烟烟草样品进行了定量分析。Vimal的尼古丁含量为2.45%,RMD为3.11%,Pan-Vilas为2.60%,Rajigandha为3.06%,Raag为3.32%。结论:在所调查的五种无烟烟草产品中,尼古丁含量存在显著差异,其中样品raag的尼古丁含量最高。商业上可买到的咀嚼烟草产品的尼古丁浓度被发现远低于吸烟形式的烟草,但较高的日均消费量使其与吸烟形式相当。
{"title":"Evaluation & Comparison of Nicotine quantification in smokeless tobacco products","authors":"G. Parmar, Ashish P. Shah, C. Aundhia, J. Chudasama","doi":"10.47552/ijam.v14i2.3632","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3632","url":null,"abstract":"Introduction: Smokeless tobacco products (STPS) represent a significant health risk and have been associated with oral and pancreatic cancers, oral lesions, coronary artery and peripheral vascular disease and adverse pregnancy outcomes. So, the aim of the present study is to perform quantitative determination of nicotine, the main alkaloid of smokeless product (Gutkha) available in Vadodara, Gujarat. Method: Collection of sample was done from local tobacco selling shopkeeper from Vadodara i.e. vimal, RMD, pan vilas, rajnigandha and raag. All the samples included in the study the same products available everywhere in Gujarat. The quantification of nicotine was done by High Performance Thin Layer Chromatography (HPTLC) using the mobile phase toluene: ethyl acetate: Diethylamine (6:4:0.5). Spectrodensitometric measurement was carried out at absorption maximum 254 nm. Results:  Five different smokeless tobacco samples were estimated using HPTLC method. Nicotine content was found to be 2.45% in Vimal, 3.11% in RMD, 2.60%- Pan Vilas, 3.06%- Rajigandha,3.32%- Raag. Conclusion: A considerable variation of nicotine content was found among the five investigated smokeless tobacco product where sample raag revealed the highest amount of nicotine than the other samples. The nicotine concentration of commercially available chewing tobacco products was found to be much lower than that of the smoking form of tobacco, but the higher average daily consumption made it comparable to the smoking form.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44722548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized single blind controlled clinical study of Tilashelukarvi Kwath in the management of Lohitkshaya Yonivyapad w.s.r. Hypomenorrhoea Tilashelukarvi Kwath治疗Lohitkshaya Yonivyapad月经过少的随机单盲对照临床研究
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.3509
Pooja D Bomshete, S. Wagh, AMit D Shinde, G. Naikwadi
Yonivyapad is a collection of diverse genital tract illnesses, from the vulva through the uterus. Lohitkshaya yonivyapad corelated with hypomenorrhoea. Hypomenorrhoea is a condition in which uterine bleeding may be slight in volume, short in duration (<2days) or both. The primary symptom of lohitkshaya is artavkshaya. Aim: To study the efficacy of Tilashelukarvi Kwath in the management of Lohitkshaya Yonivyapad w.s.r. to Hypomenorrhoea. Materials and Method: A total 80 patients of the age group 18-40 years presenting with signs and symptoms of Lohitkshaya Yonivyapad w.s.r to hypomenorrhoea were selected randomly from OPD of the department of streerog Prasutitantra. The 40 patients of trial group were treated with Tilashelukarvi kwath and 40 patients of control group were subjected to Shatapushpa churna. Results: Both treatments were equally successful in boosting blood flow during menstruation. Therefore, we draw the conclusion that the effects seen in both groups are noteworthy. 
Yonivyapad是一种从外阴到子宫的各种生殖道疾病的集合。Lohitkshaya yonivyapad与低月经相关。月经减少是指子宫出血量少、持续时间短(<2天)或两者兼而有之。lohitkshaya的主要症状是aravkshaya。目的:探讨替拉舒卡维治疗经期月经过少的疗效。材料与方法:随机选取18 ~ 40岁,在普苏泰特拉内科门诊就诊,表现为低月经症体征和症状的患者80例。试验组40例患者给予Tilashelukarvi kwath治疗,对照组40例患者给予Shatapushpa churna治疗。结果:两种治疗方法在促进月经期间的血流量方面同样成功。因此,我们得出结论,两组的效果都是值得注意的。
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引用次数: 0
Role of Ayurveda in the management of Post-traumatic chronic inflammatory synovitis of knee joint- A Case Report 阿育吠陀在创伤后慢性炎症性膝关节滑膜炎治疗中的作用- 1例报告
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.2959
Priyanka D Patil, Archana B Kukade, Dushyant D Patil, C. Bhuyan
Knee is a complex joint. It is the most commonly injured joint in the body. Trauma may injure soft tissues such as ligaments or bones of the joint. Inflammatory synovitis is one of the conditions developed after trauma. This article encompasses a diagnosed case of Post traumatic chronic inflammatory synovitis. Treatment protocol was opted considering its samprapti (Pathophysiology) as janu sandhi marmaghata. Treatment was planned considering Sandhi marmaghata. Symptomatic treatment was also considered. Significant improvement was observed in parameters like range of motion, knee joint circumference, walking distance and VAS scale within a week. No recurrence observed even after 1 year of suspended treatment. This multimodular Ayurveda treatment appears to be safe and efficient for early recovery and better outcomes. 
膝关节是一个复杂的关节。它是人体最常受伤的关节。创伤可能会损伤软组织,如韧带或关节的骨头。炎症性滑膜炎是创伤后发展的疾病之一。本文报道一例创伤后慢性炎症性滑膜炎。治疗方案选择考虑其samprapti(病理生理)为janu sandhi marmaghata。治疗计划考虑到Sandhi marmaghata。也考虑对症治疗。活动度、膝关节周长、步行距离、VAS评分等指标在一周内均有明显改善。暂停治疗1年后未见复发。这种多模块阿育吠陀治疗似乎是安全有效的早期恢复和更好的结果。
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引用次数: 0
Ayurvedic management of Asthimajja gata vatarakta (Avascular necrosis of head of the femur) – A case report 阿育吠陀治疗Asthimajja gata vatarakta(股骨头缺血性坏死)——一例报告
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.3451
Nycy B S, Rajkumar Gupta, Priyal Bansal, Utkarsha Khaire
Avascular necrosis is a condition where the bone tissue starts degenerating due to interrupted blood supply to the bone tissue. It is also known as ischemic bone necrosis, aseptic necrosis or osteonecrosis. From the contemporary medicine the management of AVN goes by pain management and joint replacement surgery. There is no direct correlation for AVN in Ayurveda. But concepts like Asthi kshaya, Asthi majja gata vata, Asthi majja gata Vatarakta symptoms stands very close to this disease condition. A female patient of age 42 came to the OPD complaining of pain in the bilateral hip joints with difficulty in walking since 6 months. MRI of the hip reveled grade 2 AVN of bilateral femur head. Patient was diagnosed as a case of Asthi majja gata Vatarakta with physical examinations. Pancha tikta ksheera kashaya, Lakshaguggulu, was given. Sandhaneeya mahakashaya gana Ksheera basti (enema with medicines processed in milk) was given to the patient for 14 days after sthanika snehana ans swedan . Pancha tikta ksheera kashaya has tikta and kashaya rasa. Tikta rasa has ashraya asharee bhava with asthi dhatu. Hence it improves the quality of asthi dhatu. Laksha guggulu helps in reducing the pain and improving the quality of rakta (rakta). Medicines included in Sandhaneeya mahakashaya gana are either Tikta, Kashya , Madhura. These rasa helps in reducing the rakta dushti (impaired circulation) and improves microcirculation. Ksheera basti helps in improving the quality of Asthi and majja dhatu. It also helps in reducing the pain in the affected region. 
无血管性坏死是由于骨组织的血液供应中断而导致骨组织开始退化的一种情况。它也被称为缺血性骨坏死、无菌性骨坏死或骨坏死。从当代医学来看,AVN的治疗主要是疼痛治疗和关节置换手术。在阿育吠陀中,AVN没有直接的联系。但是像哮喘病,哮喘病,哮喘病,哮喘病症状和这种疾病非常接近。女患者,42岁,主诉双侧髋关节疼痛,行走困难6个月。髋关节MRI示双侧股骨头2级AVN。经体格检查,患者被诊断为哮喘。Pancha tikta ksheera kashaya, Lakshaguggulu。在瑞典的sthanika snehana后,患者被给予Sandhaneeya mahakashaya gana Ksheera basti(用牛奶加工的药物灌肠)14天。Pancha tikta ksheera kashaya有tikta和kashaya rasa。Tikta rasa有ashraya asharee bhava与asthi dhatu。因此,它提高了哮喘病的质量。Laksha guggulu有助于减少疼痛和提高rakta (rakta)的质量。Sandhaneeya mahakashaya gana中包含的药物是Tikta, Kashya, Madhura。这些rasa有助于减少rakta dushti(循环受损)和改善微循环。Ksheera basti有助于提高阿斯蒂和majja dhatu的质量。它还有助于减轻患处的疼痛。
{"title":"Ayurvedic management of Asthimajja gata vatarakta (Avascular necrosis of head of the femur) – A case report","authors":"Nycy B S, Rajkumar Gupta, Priyal Bansal, Utkarsha Khaire","doi":"10.47552/ijam.v14i2.3451","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3451","url":null,"abstract":"Avascular necrosis is a condition where the bone tissue starts degenerating due to interrupted blood supply to the bone tissue. It is also known as ischemic bone necrosis, aseptic necrosis or osteonecrosis. From the contemporary medicine the management of AVN goes by pain management and joint replacement surgery. There is no direct correlation for AVN in Ayurveda. But concepts like Asthi kshaya, Asthi majja gata vata, Asthi majja gata Vatarakta symptoms stands very close to this disease condition. A female patient of age 42 came to the OPD complaining of pain in the bilateral hip joints with difficulty in walking since 6 months. MRI of the hip reveled grade 2 AVN of bilateral femur head. Patient was diagnosed as a case of Asthi majja gata Vatarakta with physical examinations. Pancha tikta ksheera kashaya, Lakshaguggulu, was given. Sandhaneeya mahakashaya gana Ksheera basti (enema with medicines processed in milk) was given to the patient for 14 days after sthanika snehana ans swedan . Pancha tikta ksheera kashaya has tikta and kashaya rasa. Tikta rasa has ashraya asharee bhava with asthi dhatu. Hence it improves the quality of asthi dhatu. Laksha guggulu helps in reducing the pain and improving the quality of rakta (rakta). Medicines included in Sandhaneeya mahakashaya gana are either Tikta, Kashya , Madhura. These rasa helps in reducing the rakta dushti (impaired circulation) and improves microcirculation. Ksheera basti helps in improving the quality of Asthi and majja dhatu. It also helps in reducing the pain in the affected region. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43070744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microplate Alamar Blue assay for detecting anti-tubercular action of Albizia amara leaves 微孔板阿拉玛蓝法检测合欢叶的抗结核作用
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.3473
R. T, S. N.
Albizia amara (Roxb.) B. Boivin has been used historically for the treatment of septicaemia, malignancy, delirium, and convulsions. A decoction made from the bark is used to treat rheumatism, hemorrhage, and some bleeding disorders during pregnancy, as well as stomach pain and nasal issues. Albizia has active ingredients like flavonoids, alkaloids, steroids, phenolic compounds, and tannins, according to early phytochemical screening. Flavonoids and phenolic compounds have been shown to play an important role in anti-tubercular activity in previous research. This led us to investigate whether or not this herb possessed anti-tubercular properties. Mycobacterium tuberculosis was found to be sensitive to concentrations of Alamar Blue dye as low as 25 μg/ml when the anti-tubercular activities of petroleum ether, methanol, and an ethanolic extract were tested. The anti-tubercular activity of the extract and fractions is comparable to that of streptomycin, pyrazinamide, and ciprofloxacin. HPTLC has shown that flavonoids and phenolic substances are present, which may explain the activity that can be seen. Taking this research on Albizia amara leaves one step further could lead to the development of a natural medicine that fights TB that is safe and works well. 
紫合欢(Roxb.)B.Boivin历来用于治疗败血症、恶性肿瘤、谵妄和抽搐。树皮制成的汤剂用于治疗风湿病、出血和妊娠期的一些出血性疾病,以及胃痛和鼻腔问题。根据早期的植物化学筛选,合欢含有黄酮类、生物碱、类固醇、酚类化合物和单宁等活性成分。黄酮类化合物和酚类化合物在抗结核活性方面具有重要作用。这使我们得以研究这种草药是否具有抗结核特性。当测试石油醚、甲醇和乙醇提取物的抗结核活性时,发现结核分枝杆菌对低至25μg/ml的Alamar Blue染料敏感。提取物和级分的抗结核活性与链霉素、吡嗪酰胺和环丙沙星相当。HPTLC显示存在类黄酮和酚类物质,这可能解释了可以看到的活性。将这项对阿尔比齐亚苋的研究向前推进一步,可能会开发出一种安全有效的对抗结核病的天然药物。
{"title":"Microplate Alamar Blue assay for detecting anti-tubercular action of Albizia amara leaves","authors":"R. T, S. N.","doi":"10.47552/ijam.v14i2.3473","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3473","url":null,"abstract":"Albizia amara (Roxb.) B. Boivin has been used historically for the treatment of septicaemia, malignancy, delirium, and convulsions. A decoction made from the bark is used to treat rheumatism, hemorrhage, and some bleeding disorders during pregnancy, as well as stomach pain and nasal issues. Albizia has active ingredients like flavonoids, alkaloids, steroids, phenolic compounds, and tannins, according to early phytochemical screening. Flavonoids and phenolic compounds have been shown to play an important role in anti-tubercular activity in previous research. This led us to investigate whether or not this herb possessed anti-tubercular properties. Mycobacterium tuberculosis was found to be sensitive to concentrations of Alamar Blue dye as low as 25 μg/ml when the anti-tubercular activities of petroleum ether, methanol, and an ethanolic extract were tested. The anti-tubercular activity of the extract and fractions is comparable to that of streptomycin, pyrazinamide, and ciprofloxacin. HPTLC has shown that flavonoids and phenolic substances are present, which may explain the activity that can be seen. Taking this research on Albizia amara leaves one step further could lead to the development of a natural medicine that fights TB that is safe and works well. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43239069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on examination of breast milk in Ayurveda and its physicochemical properties with its component 阿育吠陀母乳及其成分的理化性质研究进展
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-07-03 DOI: 10.47552/ijam.v14i2.3571
Nishahun Wahlang, Renu Rathi
Background: Breast milk is the only and complete nutrition supply for infants breastfeeding contains all the necessary elements for healthy baby growth and development. Breast milk contains bioactive agents that help in the proper functioning of the gastrointestinal system which affects the circulatory system. Objectives: The objective is to review recent findings on the different content and components of breast milk from premature and term infants, examination protocol of breast milk, the physicochemical properties of mature breast milk, recent knowledge of the prebiotic and probiotic effect of breast milk through different articles, classical books of Ayurveda then summarized the evidence available. Materials and methods: The information is collected from articles which are from PUBMED, SCOPUS, GOOGLE SCHOLAR, and only classical books of Ayurveda. Observation: The composition of breast milk including protein, carbohydrate, fat, minerals, vitamin, and immunoglobulin contribute to the nutrition and immunity action of breast milk. The composition of breast milk i.e. macronutrients and micronutrients differ at different stages of breast milk including colostrums, transitional and mature milk. The result of physicochemical properties differs according to the methods used for the evaluation of the different physicochemical properties of breast milk but the mean value is taken into consideration. Results: The different parameters in the examination of breast milk as per Ayurveda. The physicochemical properties of breast milk include pH, specific gravity, electrical conductivity, viscosity, water activity, osmolarity, refractive index, freezing point, and surface tension.
背景:母乳是婴儿唯一和完整的营养供应,母乳喂养包含婴儿健康生长和发育的所有必要元素。母乳中含有生物活性物质,有助于胃肠系统的正常运作,从而影响循环系统。目的:目的是通过不同的文章和阿育吠陀经典书籍,回顾最近关于早产儿和足月婴儿母乳的不同含量和成分,母乳的检查方案,成熟母乳的理化性质,母乳的益生元和益生菌作用的最新知识,然后总结现有的证据。材料和方法:资料来源于PUBMED, SCOPUS,谷歌SCHOLAR等文献,仅收录阿育吠陀经典书籍。观察:母乳中的蛋白质、碳水化合物、脂肪、矿物质、维生素、免疫球蛋白等组成有助于母乳的营养和免疫作用。母乳的成分,即常量营养素和微量营养素在母乳的不同阶段有所不同,包括初乳、过渡乳和成熟乳。根据不同的母乳理化性质的评价方法,理化性质的结果会有所不同,但要考虑其平均值。结果:根据阿育吠陀的说法,母乳检查中的不同参数。母乳的理化性质包括pH值、比重、电导率、粘度、水活度、渗透压、折射率、冰点和表面张力。
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International Journal of Ayurvedic Medicine
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