Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3481
Karim Nikkhah, Ali Shoeibi, Fariborz Rezaeitalab, Samira Aminzadeh, Hussein Sharara, Mahdi Abbas-Mohammadi, Mohammad Al-attar, Mohammadeza Akbari, Fereydun Moradi, Hasan Rakhshandeh, Morteza Saeidi
Background: Parkinson’s disease is a chronic degenerative disease of the central nervous system, presently lacks an effective therapy for its complex pathogenesis. Agents containing Levodopa can alleviate its symptoms. Hypothesis Vicia faba L. (Fava bean) extract may prove a useful antiparkinsonian agent similar to Levodopa. Methods: Thirty patients with Parkinson’s disease, entered into this cross over clinical study. In the first step, each participant received V. faba L. extract containing 106.5 mg of Levodopa. After a wash out period of 7 days, the patients entered the second step during which they received conventional treatment with Levodopa-C tablets. Blood Levodopa were measured 4 hours and 8 hours after each administration. The Movement Disorder Society-Unified Parkinson’s Disease Rating Scale was employed to measure the therapeutic effects in each step. Additionally, a docking analysis was performed to distinguish the chemical constituents of the plant and six key mediators actively involved in Parkinson disease. Results: The fava bean extract significantly alleviate all studied end points except for tremor at rest and freezing. Wilcoxon Signed Ranks Test showed that there was not a significant difference between rigidity, rising chair, gait and bradykinesia. Docking results of the herb components and standard ligands, indicating that the antiparkinsonian activity of V. faba could presumably be related to many phytochemicals. Conclusion: This study showed a beneficial effect of V. faba L. similar to Levodopa-C. and better compliance due to lower adverse events.
{"title":"Efficacy and safety of Vicia faba L. extract compared with levodopa in management of Parkinson’s disease and an in‐silico phytomedicine analysis","authors":"Karim Nikkhah, Ali Shoeibi, Fariborz Rezaeitalab, Samira Aminzadeh, Hussein Sharara, Mahdi Abbas-Mohammadi, Mohammad Al-attar, Mohammadeza Akbari, Fereydun Moradi, Hasan Rakhshandeh, Morteza Saeidi","doi":"10.47552/ijam.v14i3.3481","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3481","url":null,"abstract":"Background: Parkinson’s disease is a chronic degenerative disease of the central nervous system, presently lacks an effective therapy for its complex pathogenesis. Agents containing Levodopa can alleviate its symptoms. Hypothesis Vicia faba L. (Fava bean) extract may prove a useful antiparkinsonian agent similar to Levodopa. Methods: Thirty patients with Parkinson’s disease, entered into this cross over clinical study. In the first step, each participant received V. faba L. extract containing 106.5 mg of Levodopa. After a wash out period of 7 days, the patients entered the second step during which they received conventional treatment with Levodopa-C tablets. Blood Levodopa were measured 4 hours and 8 hours after each administration. The Movement Disorder Society-Unified Parkinson’s Disease Rating Scale was employed to measure the therapeutic effects in each step. Additionally, a docking analysis was performed to distinguish the chemical constituents of the plant and six key mediators actively involved in Parkinson disease. Results: The fava bean extract significantly alleviate all studied end points except for tremor at rest and freezing. Wilcoxon Signed Ranks Test showed that there was not a significant difference between rigidity, rising chair, gait and bradykinesia. Docking results of the herb components and standard ligands, indicating that the antiparkinsonian activity of V. faba could presumably be related to many phytochemicals. Conclusion: This study showed a beneficial effect of V. faba L. similar to Levodopa-C. and better compliance due to lower adverse events.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3629
Rodica Catana, Mirela M. Moldoveanu, Raluca A. Mihai, Anca Botezatu, Adrian Albulescu, Anush Kosakyan, Larisa Florescu
Plants are an important means of combating numerous harmful influences on humans (microorganisms, viruses, fungi, etc.) and have always been used to treat various diseases. In the context of the Covid pandemic, interest in the use of plants has increased. Great importance has been given to screening plants' potential against Covid (antiviral, anti-inflammatory, immunostimulatory, and antioxidant). According to recent research, many of the plant species used against Covid are of Asian origin. In this review, we aim to discuss the plant species with these medicinal potentials with a focus on Romanian flora. We have listed a total of 50 Phyto-resources from Romanian flora with different potentials: 26 containing the confirmed anti-covid compounds, and 9 species having antiviral, anti-inflammatory, immunostimulant, and antioxidant potentials.
{"title":"Screening of Phytoresources from the Romanian Flora with medical applications against Covid - Review","authors":"Rodica Catana, Mirela M. Moldoveanu, Raluca A. Mihai, Anca Botezatu, Adrian Albulescu, Anush Kosakyan, Larisa Florescu","doi":"10.47552/ijam.v14i3.3629","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3629","url":null,"abstract":"Plants are an important means of combating numerous harmful influences on humans (microorganisms, viruses, fungi, etc.) and have always been used to treat various diseases. In the context of the Covid pandemic, interest in the use of plants has increased. Great importance has been given to screening plants' potential against Covid (antiviral, anti-inflammatory, immunostimulatory, and antioxidant). According to recent research, many of the plant species used against Covid are of Asian origin. In this review, we aim to discuss the plant species with these medicinal potentials with a focus on Romanian flora. We have listed a total of 50 Phyto-resources from Romanian flora with different potentials: 26 containing the confirmed anti-covid compounds, and 9 species having antiviral, anti-inflammatory, immunostimulant, and antioxidant potentials.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3529
D. Bisht, Deena Prakash, D. Yadav, A. Shakya, Ramesh Kumar, S. Shrivastava, S. Shukla
Polyalthia longifolia (Sonn.) Thwaites is a traditional medicinal plant with diverse medicinal properties including kidney protection. The present investigation was aimed to assess the phytochemical content, antioxidant activity and evaluate nephroprotective activity of Polyalthia longifolia (PL) 70% ethanolic leaf extract against cisplatin and gentamicin-induced toxicity on HEK293 cell line. Phytochemical analysis confirmed the presence of flavonoids, reducing sugars, tannins, coumarin, saponins, alkaloids, and glycosides, as well as the abundant total phenolic and total flavonoid content in the PL leaf extract. The extract exhibited significant free radical scavenging activity (p<0.001) in ABTS (IC50 224 μg/mL), DPPH (IC50 150.1 μg/mL) and H2O2 (IC50 271.1 μg/mL) assays. In vitro MTT assay validated remarkable cytoprotective activity (p<0.001) of PL leaf extract at three concentrations (125 μg/mL, 250 μg/mL, 500 μg/mL) against cisplatin and gentamicin treated HEK293 cell line in dose dependent manner with 70% cell viability (IC50 312.6 µg/mL) and 72% cell viability (IC50 307.3 µg/mL), respectively, at PL dose 500 μg/mL. The cytotoxicity assay also confirmed no adverse effect of PL leaf extract on cell viability in the HEK293 and considered as nontoxic when compared with normal control group. The present study revealed that Polyalthia longifolia leaf extract has remarkable antioxidant activity and nephroprotective properties against cisplatin and gentamicin induced nephrotoxicity in in vitro model which might be due the presence of free radical scavenging phytochemicals.
{"title":"In vitro antioxidant and nephroprotective properties of Polyalthia longifolia: A traditional medicinal plant","authors":"D. Bisht, Deena Prakash, D. Yadav, A. Shakya, Ramesh Kumar, S. Shrivastava, S. Shukla","doi":"10.47552/ijam.v14i2.3529","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3529","url":null,"abstract":"Polyalthia longifolia (Sonn.) Thwaites is a traditional medicinal plant with diverse medicinal properties including kidney protection. The present investigation was aimed to assess the phytochemical content, antioxidant activity and evaluate nephroprotective activity of Polyalthia longifolia (PL) 70% ethanolic leaf extract against cisplatin and gentamicin-induced toxicity on HEK293 cell line. Phytochemical analysis confirmed the presence of flavonoids, reducing sugars, tannins, coumarin, saponins, alkaloids, and glycosides, as well as the abundant total phenolic and total flavonoid content in the PL leaf extract. The extract exhibited significant free radical scavenging activity (p<0.001) in ABTS (IC50 224 μg/mL), DPPH (IC50 150.1 μg/mL) and H2O2 (IC50 271.1 μg/mL) assays. In vitro MTT assay validated remarkable cytoprotective activity (p<0.001) of PL leaf extract at three concentrations (125 μg/mL, 250 μg/mL, 500 μg/mL) against cisplatin and gentamicin treated HEK293 cell line in dose dependent manner with 70% cell viability (IC50 312.6 µg/mL) and 72% cell viability (IC50 307.3 µg/mL), respectively, at PL dose 500 μg/mL. The cytotoxicity assay also confirmed no adverse effect of PL leaf extract on cell viability in the HEK293 and considered as nontoxic when compared with normal control group. The present study revealed that Polyalthia longifolia leaf extract has remarkable antioxidant activity and nephroprotective properties against cisplatin and gentamicin induced nephrotoxicity in in vitro model which might be due the presence of free radical scavenging phytochemicals. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44077452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3547
S. Tavhare, Karan Lakhani
Background: Healthcare associated infections includes infestation by bacteria, viruses and fungi. As per WHO estimates, approximately 15% of all hospitalized patients suffer from these nosocomial infections caused by these micro-organisms. Outbreaks of such infections increases the use of antibiotics, vitamins and immonomodulator medicines. During ancient times, to prevent spread of infections; fumigation with herbs was a practice and it is still seen continued. Material & methods: Good quality herbal fumigants like Guggulu gum-resin, turmeric powder, spikenard rhizome, white mustard fruits, caraway fruits, camphor resins and cow’s ghee were used for fumigation of various hospital rooms like out-patient department room, dental clinic, gynecological procedure room, physiotherapy and operation theatre of Community Healthcare Center, Sarsa. Swabs from these units were tested for bacterial and fungal load before and after experiment by using culture media’s like nutrient broth and potato dextrose agar respectively. Results: The bacteria culture reported organisms namely Bacilus subtilis, Bacilus megaterium, Staphylococcus aureus, Micrococcus luteus and fungi like Aspergillus niger, mucor and rhizophus. After 30 minutes of fumigation procedure, significant reduction in bacterial colonies was found in gynecological procedure room, dental clinic, OPD and physiotherapy room while statistically non-significant results were observed in operation theatre. Two hours after fumigation, statistically significant result was observed in bacterial count in all studied units except operation theatre while fungal colonies reduction was achieved in all studied units. Conclusion: Fumigation shall be encouraged in hospital units like out patients department, wards and minor procedure rooms but may not be perfectly suitable for operative theatres always. The study encourages daily herbal fumigation of home and surroundings for hygienic and pleasant environment.
{"title":"Validation of hospital environmental disinfection efficiency of herbal fumigants","authors":"S. Tavhare, Karan Lakhani","doi":"10.47552/ijam.v14i2.3547","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3547","url":null,"abstract":"Background: Healthcare associated infections includes infestation by bacteria, viruses and fungi. As per WHO estimates, approximately 15% of all hospitalized patients suffer from these nosocomial infections caused by these micro-organisms. Outbreaks of such infections increases the use of antibiotics, vitamins and immonomodulator medicines. During ancient times, to prevent spread of infections; fumigation with herbs was a practice and it is still seen continued. Material & methods: Good quality herbal fumigants like Guggulu gum-resin, turmeric powder, spikenard rhizome, white mustard fruits, caraway fruits, camphor resins and cow’s ghee were used for fumigation of various hospital rooms like out-patient department room, dental clinic, gynecological procedure room, physiotherapy and operation theatre of Community Healthcare Center, Sarsa. Swabs from these units were tested for bacterial and fungal load before and after experiment by using culture media’s like nutrient broth and potato dextrose agar respectively. Results: The bacteria culture reported organisms namely Bacilus subtilis, Bacilus megaterium, Staphylococcus aureus, Micrococcus luteus and fungi like Aspergillus niger, mucor and rhizophus. After 30 minutes of fumigation procedure, significant reduction in bacterial colonies was found in gynecological procedure room, dental clinic, OPD and physiotherapy room while statistically non-significant results were observed in operation theatre. Two hours after fumigation, statistically significant result was observed in bacterial count in all studied units except operation theatre while fungal colonies reduction was achieved in all studied units. Conclusion: Fumigation shall be encouraged in hospital units like out patients department, wards and minor procedure rooms but may not be perfectly suitable for operative theatres always. The study encourages daily herbal fumigation of home and surroundings for hygienic and pleasant environment.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48885452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3632
G. Parmar, Ashish P. Shah, C. Aundhia, J. Chudasama
Introduction: Smokeless tobacco products (STPS) represent a significant health risk and have been associated with oral and pancreatic cancers, oral lesions, coronary artery and peripheral vascular disease and adverse pregnancy outcomes. So, the aim of the present study is to perform quantitative determination of nicotine, the main alkaloid of smokeless product (Gutkha) available in Vadodara, Gujarat. Method: Collection of sample was done from local tobacco selling shopkeeper from Vadodara i.e. vimal, RMD, pan vilas, rajnigandha and raag. All the samples included in the study the same products available everywhere in Gujarat. The quantification of nicotine was done by High Performance Thin Layer Chromatography (HPTLC) using the mobile phase toluene: ethyl acetate: Diethylamine (6:4:0.5). Spectrodensitometric measurement was carried out at absorption maximum 254 nm. Results: Five different smokeless tobacco samples were estimated using HPTLC method. Nicotine content was found to be 2.45% in Vimal, 3.11% in RMD, 2.60%- Pan Vilas, 3.06%- Rajigandha,3.32%- Raag. Conclusion: A considerable variation of nicotine content was found among the five investigated smokeless tobacco product where sample raag revealed the highest amount of nicotine than the other samples. The nicotine concentration of commercially available chewing tobacco products was found to be much lower than that of the smoking form of tobacco, but the higher average daily consumption made it comparable to the smoking form.
{"title":"Evaluation & Comparison of Nicotine quantification in smokeless tobacco products","authors":"G. Parmar, Ashish P. Shah, C. Aundhia, J. Chudasama","doi":"10.47552/ijam.v14i2.3632","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3632","url":null,"abstract":"Introduction: Smokeless tobacco products (STPS) represent a significant health risk and have been associated with oral and pancreatic cancers, oral lesions, coronary artery and peripheral vascular disease and adverse pregnancy outcomes. So, the aim of the present study is to perform quantitative determination of nicotine, the main alkaloid of smokeless product (Gutkha) available in Vadodara, Gujarat. Method: Collection of sample was done from local tobacco selling shopkeeper from Vadodara i.e. vimal, RMD, pan vilas, rajnigandha and raag. All the samples included in the study the same products available everywhere in Gujarat. The quantification of nicotine was done by High Performance Thin Layer Chromatography (HPTLC) using the mobile phase toluene: ethyl acetate: Diethylamine (6:4:0.5). Spectrodensitometric measurement was carried out at absorption maximum 254 nm. Results: Five different smokeless tobacco samples were estimated using HPTLC method. Nicotine content was found to be 2.45% in Vimal, 3.11% in RMD, 2.60%- Pan Vilas, 3.06%- Rajigandha,3.32%- Raag. Conclusion: A considerable variation of nicotine content was found among the five investigated smokeless tobacco product where sample raag revealed the highest amount of nicotine than the other samples. The nicotine concentration of commercially available chewing tobacco products was found to be much lower than that of the smoking form of tobacco, but the higher average daily consumption made it comparable to the smoking form.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44722548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3509
Pooja D Bomshete, S. Wagh, AMit D Shinde, G. Naikwadi
Yonivyapad is a collection of diverse genital tract illnesses, from the vulva through the uterus. Lohitkshaya yonivyapad corelated with hypomenorrhoea. Hypomenorrhoea is a condition in which uterine bleeding may be slight in volume, short in duration (<2days) or both. The primary symptom of lohitkshaya is artavkshaya. Aim: To study the efficacy of Tilashelukarvi Kwath in the management of Lohitkshaya Yonivyapad w.s.r. to Hypomenorrhoea. Materials and Method: A total 80 patients of the age group 18-40 years presenting with signs and symptoms of Lohitkshaya Yonivyapad w.s.r to hypomenorrhoea were selected randomly from OPD of the department of streerog Prasutitantra. The 40 patients of trial group were treated with Tilashelukarvi kwath and 40 patients of control group were subjected to Shatapushpa churna. Results: Both treatments were equally successful in boosting blood flow during menstruation. Therefore, we draw the conclusion that the effects seen in both groups are noteworthy.
{"title":"A randomized single blind controlled clinical study of Tilashelukarvi Kwath in the management of Lohitkshaya Yonivyapad w.s.r. Hypomenorrhoea","authors":"Pooja D Bomshete, S. Wagh, AMit D Shinde, G. Naikwadi","doi":"10.47552/ijam.v14i2.3509","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3509","url":null,"abstract":"Yonivyapad is a collection of diverse genital tract illnesses, from the vulva through the uterus. Lohitkshaya yonivyapad corelated with hypomenorrhoea. Hypomenorrhoea is a condition in which uterine bleeding may be slight in volume, short in duration (<2days) or both. The primary symptom of lohitkshaya is artavkshaya. Aim: To study the efficacy of Tilashelukarvi Kwath in the management of Lohitkshaya Yonivyapad w.s.r. to Hypomenorrhoea. Materials and Method: A total 80 patients of the age group 18-40 years presenting with signs and symptoms of Lohitkshaya Yonivyapad w.s.r to hypomenorrhoea were selected randomly from OPD of the department of streerog Prasutitantra. The 40 patients of trial group were treated with Tilashelukarvi kwath and 40 patients of control group were subjected to Shatapushpa churna. Results: Both treatments were equally successful in boosting blood flow during menstruation. Therefore, we draw the conclusion that the effects seen in both groups are noteworthy. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44797997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.2959
Priyanka D Patil, Archana B Kukade, Dushyant D Patil, C. Bhuyan
Knee is a complex joint. It is the most commonly injured joint in the body. Trauma may injure soft tissues such as ligaments or bones of the joint. Inflammatory synovitis is one of the conditions developed after trauma. This article encompasses a diagnosed case of Post traumatic chronic inflammatory synovitis. Treatment protocol was opted considering its samprapti (Pathophysiology) as janu sandhi marmaghata. Treatment was planned considering Sandhi marmaghata. Symptomatic treatment was also considered. Significant improvement was observed in parameters like range of motion, knee joint circumference, walking distance and VAS scale within a week. No recurrence observed even after 1 year of suspended treatment. This multimodular Ayurveda treatment appears to be safe and efficient for early recovery and better outcomes.
{"title":"Role of Ayurveda in the management of Post-traumatic chronic inflammatory synovitis of knee joint- A Case Report","authors":"Priyanka D Patil, Archana B Kukade, Dushyant D Patil, C. Bhuyan","doi":"10.47552/ijam.v14i2.2959","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.2959","url":null,"abstract":"Knee is a complex joint. It is the most commonly injured joint in the body. Trauma may injure soft tissues such as ligaments or bones of the joint. Inflammatory synovitis is one of the conditions developed after trauma. This article encompasses a diagnosed case of Post traumatic chronic inflammatory synovitis. Treatment protocol was opted considering its samprapti (Pathophysiology) as janu sandhi marmaghata. Treatment was planned considering Sandhi marmaghata. Symptomatic treatment was also considered. Significant improvement was observed in parameters like range of motion, knee joint circumference, walking distance and VAS scale within a week. No recurrence observed even after 1 year of suspended treatment. This multimodular Ayurveda treatment appears to be safe and efficient for early recovery and better outcomes. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43451086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3451
Nycy B S, Rajkumar Gupta, Priyal Bansal, Utkarsha Khaire
Avascular necrosis is a condition where the bone tissue starts degenerating due to interrupted blood supply to the bone tissue. It is also known as ischemic bone necrosis, aseptic necrosis or osteonecrosis. From the contemporary medicine the management of AVN goes by pain management and joint replacement surgery. There is no direct correlation for AVN in Ayurveda. But concepts like Asthi kshaya, Asthi majja gata vata, Asthi majja gata Vatarakta symptoms stands very close to this disease condition. A female patient of age 42 came to the OPD complaining of pain in the bilateral hip joints with difficulty in walking since 6 months. MRI of the hip reveled grade 2 AVN of bilateral femur head. Patient was diagnosed as a case of Asthi majja gata Vatarakta with physical examinations. Pancha tikta ksheera kashaya, Lakshaguggulu, was given. Sandhaneeya mahakashaya gana Ksheera basti (enema with medicines processed in milk) was given to the patient for 14 days after sthanika snehana ans swedan . Pancha tikta ksheera kashaya has tikta and kashaya rasa. Tikta rasa has ashraya asharee bhava with asthi dhatu. Hence it improves the quality of asthi dhatu. Laksha guggulu helps in reducing the pain and improving the quality of rakta (rakta). Medicines included in Sandhaneeya mahakashaya gana are either Tikta, Kashya , Madhura. These rasa helps in reducing the rakta dushti (impaired circulation) and improves microcirculation. Ksheera basti helps in improving the quality of Asthi and majja dhatu. It also helps in reducing the pain in the affected region.
{"title":"Ayurvedic management of Asthimajja gata vatarakta (Avascular necrosis of head of the femur) – A case report","authors":"Nycy B S, Rajkumar Gupta, Priyal Bansal, Utkarsha Khaire","doi":"10.47552/ijam.v14i2.3451","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3451","url":null,"abstract":"Avascular necrosis is a condition where the bone tissue starts degenerating due to interrupted blood supply to the bone tissue. It is also known as ischemic bone necrosis, aseptic necrosis or osteonecrosis. From the contemporary medicine the management of AVN goes by pain management and joint replacement surgery. There is no direct correlation for AVN in Ayurveda. But concepts like Asthi kshaya, Asthi majja gata vata, Asthi majja gata Vatarakta symptoms stands very close to this disease condition. A female patient of age 42 came to the OPD complaining of pain in the bilateral hip joints with difficulty in walking since 6 months. MRI of the hip reveled grade 2 AVN of bilateral femur head. Patient was diagnosed as a case of Asthi majja gata Vatarakta with physical examinations. Pancha tikta ksheera kashaya, Lakshaguggulu, was given. Sandhaneeya mahakashaya gana Ksheera basti (enema with medicines processed in milk) was given to the patient for 14 days after sthanika snehana ans swedan . Pancha tikta ksheera kashaya has tikta and kashaya rasa. Tikta rasa has ashraya asharee bhava with asthi dhatu. Hence it improves the quality of asthi dhatu. Laksha guggulu helps in reducing the pain and improving the quality of rakta (rakta). Medicines included in Sandhaneeya mahakashaya gana are either Tikta, Kashya , Madhura. These rasa helps in reducing the rakta dushti (impaired circulation) and improves microcirculation. Ksheera basti helps in improving the quality of Asthi and majja dhatu. It also helps in reducing the pain in the affected region. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43070744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3473
R. T, S. N.
Albizia amara (Roxb.) B. Boivin has been used historically for the treatment of septicaemia, malignancy, delirium, and convulsions. A decoction made from the bark is used to treat rheumatism, hemorrhage, and some bleeding disorders during pregnancy, as well as stomach pain and nasal issues. Albizia has active ingredients like flavonoids, alkaloids, steroids, phenolic compounds, and tannins, according to early phytochemical screening. Flavonoids and phenolic compounds have been shown to play an important role in anti-tubercular activity in previous research. This led us to investigate whether or not this herb possessed anti-tubercular properties. Mycobacterium tuberculosis was found to be sensitive to concentrations of Alamar Blue dye as low as 25 μg/ml when the anti-tubercular activities of petroleum ether, methanol, and an ethanolic extract were tested. The anti-tubercular activity of the extract and fractions is comparable to that of streptomycin, pyrazinamide, and ciprofloxacin. HPTLC has shown that flavonoids and phenolic substances are present, which may explain the activity that can be seen. Taking this research on Albizia amara leaves one step further could lead to the development of a natural medicine that fights TB that is safe and works well.
{"title":"Microplate Alamar Blue assay for detecting anti-tubercular action of Albizia amara leaves","authors":"R. T, S. N.","doi":"10.47552/ijam.v14i2.3473","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3473","url":null,"abstract":"Albizia amara (Roxb.) B. Boivin has been used historically for the treatment of septicaemia, malignancy, delirium, and convulsions. A decoction made from the bark is used to treat rheumatism, hemorrhage, and some bleeding disorders during pregnancy, as well as stomach pain and nasal issues. Albizia has active ingredients like flavonoids, alkaloids, steroids, phenolic compounds, and tannins, according to early phytochemical screening. Flavonoids and phenolic compounds have been shown to play an important role in anti-tubercular activity in previous research. This led us to investigate whether or not this herb possessed anti-tubercular properties. Mycobacterium tuberculosis was found to be sensitive to concentrations of Alamar Blue dye as low as 25 μg/ml when the anti-tubercular activities of petroleum ether, methanol, and an ethanolic extract were tested. The anti-tubercular activity of the extract and fractions is comparable to that of streptomycin, pyrazinamide, and ciprofloxacin. HPTLC has shown that flavonoids and phenolic substances are present, which may explain the activity that can be seen. Taking this research on Albizia amara leaves one step further could lead to the development of a natural medicine that fights TB that is safe and works well. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43239069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3571
Nishahun Wahlang, Renu Rathi
Background: Breast milk is the only and complete nutrition supply for infants breastfeeding contains all the necessary elements for healthy baby growth and development. Breast milk contains bioactive agents that help in the proper functioning of the gastrointestinal system which affects the circulatory system. Objectives: The objective is to review recent findings on the different content and components of breast milk from premature and term infants, examination protocol of breast milk, the physicochemical properties of mature breast milk, recent knowledge of the prebiotic and probiotic effect of breast milk through different articles, classical books of Ayurveda then summarized the evidence available. Materials and methods: The information is collected from articles which are from PUBMED, SCOPUS, GOOGLE SCHOLAR, and only classical books of Ayurveda. Observation: The composition of breast milk including protein, carbohydrate, fat, minerals, vitamin, and immunoglobulin contribute to the nutrition and immunity action of breast milk. The composition of breast milk i.e. macronutrients and micronutrients differ at different stages of breast milk including colostrums, transitional and mature milk. The result of physicochemical properties differs according to the methods used for the evaluation of the different physicochemical properties of breast milk but the mean value is taken into consideration. Results: The different parameters in the examination of breast milk as per Ayurveda. The physicochemical properties of breast milk include pH, specific gravity, electrical conductivity, viscosity, water activity, osmolarity, refractive index, freezing point, and surface tension.
{"title":"A review on examination of breast milk in Ayurveda and its physicochemical properties with its component","authors":"Nishahun Wahlang, Renu Rathi","doi":"10.47552/ijam.v14i2.3571","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3571","url":null,"abstract":"Background: Breast milk is the only and complete nutrition supply for infants breastfeeding contains all the necessary elements for healthy baby growth and development. Breast milk contains bioactive agents that help in the proper functioning of the gastrointestinal system which affects the circulatory system. Objectives: The objective is to review recent findings on the different content and components of breast milk from premature and term infants, examination protocol of breast milk, the physicochemical properties of mature breast milk, recent knowledge of the prebiotic and probiotic effect of breast milk through different articles, classical books of Ayurveda then summarized the evidence available. Materials and methods: The information is collected from articles which are from PUBMED, SCOPUS, GOOGLE SCHOLAR, and only classical books of Ayurveda. Observation: The composition of breast milk including protein, carbohydrate, fat, minerals, vitamin, and immunoglobulin contribute to the nutrition and immunity action of breast milk. The composition of breast milk i.e. macronutrients and micronutrients differ at different stages of breast milk including colostrums, transitional and mature milk. The result of physicochemical properties differs according to the methods used for the evaluation of the different physicochemical properties of breast milk but the mean value is taken into consideration. Results: The different parameters in the examination of breast milk as per Ayurveda. The physicochemical properties of breast milk include pH, specific gravity, electrical conductivity, viscosity, water activity, osmolarity, refractive index, freezing point, and surface tension.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42245953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}