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Ethnobotanical and dietary uses of Bamboo unveiled by the tribes and local inhabitants of Chittoor district, West Godavari and East Godavari districts of Andhra Pradesh 安得拉邦Chittoor区、West Godavari和East Godavari区的部落和当地居民公布的竹子的民族植物学和饮食用途
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.2289
G. Prasad, P. Goli, Mohd. Kashif Husain, S. Prasad, A. Gurav, Srikanth Narayanam
Aim and Objective: To unveil and document the folklore claims and dietary recipes of Bambusa bambos and Dendrocalamus strictus. Materials and methods: The study was intended to examine the 101 tribal individuals like traditional healers, tribal doctors and elder people in the field trips on their regular utilization of different species of Bamboo. Results: The study explored 13 contemporary folklore claims on B. bambos and D. strictus species solicited from various tribal pockets of Chittoor District, Andhra Pradesh and dietary recipes from the tribes of West Godavari  and East Godavari  districts, Andhra Pradesh. Conclusion: With this study, it can be concluded that various parts of Bambusa bambos and Dendrocalamus strictus are practiced as conventional drugs to treat different ailments by local tribes and conventional healers from Chittoor district, Andhra Pradesh. Besides this, the young shoots of Bambusa bambos are a fabulous dietary hotspot for several minerals. This recipe of Bamboo shoots has been in permanence among the tribes of West Godavari and East Godavari  districts for the past several generations. Ayurveda has also validated this fact owing to its therapeutic properties. By all its nutritive potential, it can be determined that it is not only good to the taste receptors but also healthy.
目的:揭示和记载竹和细竹的民间传说和食谱。材料和方法:本研究旨在调查101名在实地考察中的部落个体,如传统治疗师、部落医生和老年人,对不同种类竹子的常规利用情况。结果:该研究探讨了从安得拉邦奇托尔区的各个部落地区征集的13种关于B.bambos和D.strictus物种的当代民间传说,以及从安得拉邦西戈达瓦里和东戈达瓦里地区的部落获得的饮食食谱。结论:通过这项研究,可以得出结论,当地部落和来自安得拉邦奇托尔区的传统治疗师将竹和细竹的不同部位作为治疗不同疾病的传统药物。除此之外,竹的嫩芽也是多种矿物质的绝佳饮食热点。在过去的几代人中,这种竹笋配方在西戈达瓦里和东戈达瓦里区的部落中一直存在。阿育吠陀也因其治疗特性而证实了这一事实。根据其所有的营养潜力,可以确定它不仅对味觉受体有益,而且是健康的。
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引用次数: 0
A narrative review on concept of Bala and immunity in Ayurveda physiology 阿育吠陀生理学中巴拉和免疫概念的叙述性评述
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3223
Sonam Agrawal, Aparna Singh, S. Gehlot
Bala in Ayurveda physiology is a multidimensional factor that refers to physical and psychological strength and the ability produced in response to antigen exposure and resistance against the manifestation of disease. It has also been synonymously used for components providing strength, nourishment, and stability to the body such as Oja, Vyadhikshamatva, Balya, Sara, Balavriddhikara Bhava, Prakrita Sleshma. The Bala of a person is determined by a complex interaction of multifactor such as Balavriddhikara Bhava, Dhatu Sarata, Prakriti, indulgence in dietary and behavioural activities, inherent qualities, etc. Further, it has also been opined that the Bala of a person cannot be assessed by just observing his body physique, as it has been seen that a person having a well-formed body does not always have good strength. In contrast, a person with a lean body may have excellent stability. As the Bala of a person serves as an important criterion for assessment of the severity as well as prognosis of disease, there is a need for the development of objective parameters for its assessment and implication in clinical practices. 
阿育吠陀生理学中的巴拉是一个多维因素,指的是身体和心理力量以及对抗原暴露和抵抗疾病表现所产生的能力。它也被同义地用于为身体提供力量、营养和稳定性的成分,如Oja、Vyadhikshamatva、Balya、Sara、Balavriddhikara Bhava、Prakrita Sleshma。一个人的Bala是由多因素的复杂相互作用决定的,如Balavriddhikara Bhava、Dhatu Sarata、Prakriti、对饮食和行为活动的放纵、内在品质等,正如已经看到的那样,具有良好成形的身体的人并不总是具有良好的力量。相比之下,一个身体瘦削的人可能具有极好的稳定性。由于一个人的Bala是评估疾病严重程度和预后的重要标准,因此需要制定客观参数来评估其在临床实践中的作用。
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引用次数: 0
Efficacy of Sarjadi Lepa Gutika and Terbinafine Ointment in Dadru (Tinea Corporis) Sarjadi Lepa Gutika 和特比萘芬软膏对 Dadru(体癣)的疗效
Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3213
Shreyas S Kulkarni, Sadhana Misar Wajpeyi
The term 'Kushtha' can be referred to various skin disorders. 'Dadru' is a type of Kushtha. In Dadru there is pradhanata of Kaphaa nd Pitta Dosha. It exhibits clinical features of Kandu, Raga, Pidika ,Utsanna Mandala. On basis of clinical features Dadru is compared with Tinea by many scholars. Tinea is superficial fungal infection in which the fungi colonises dead keratinized epidermal tissues of skin, hair and nails and produces annular lesions over skin surface. Aim- Efficacy of Sarjadi Lepa Gutika and Terbinafine Ointment along with Tiladi Churna internally in Dadru (Tinea Corporis). Material and Methods – Study contains 60 patients of Dadru which were divided into two groups (3o in each group). In Group A (Intervention) Sarjadi Lepa Gutika for local application twice daily and Tiladi Churna 6gm at morning after meal for 30 days was given. In Group B (Experimental group) Terbinafine Ointment for local application twice daily and Tiladi Churna 6gm at morning after meal 30 days was given. Assessment was recorded on every 15th day (15th day, 30th day and 45th day). Result – Both the groups were equally effective in reducing Kandu, Raaga and Manadala utpatti. Conclusion – : Sarjadi Lepa Gutika is as effective as Terbinafine ointment in the management of Dadru (Tinea corporis) and it may prevent recurrence if combined with Tiladi Churna as Abhyantar Chikitsa.
“库什塔”一词可以指各种皮肤疾病。“达德鲁”是库什塔的一种。在达德鲁有Kaphaa和Pitta Dosha的pradhanata。它具有Kandu, Raga, Pidika,Utsanna Mandala的临床特征。根据大如的临床特点,许多学者将其与足癣进行了比较。癣是一种浅表真菌感染,真菌寄生于皮肤、头发和指甲角质化的表皮组织,并在皮肤表面产生环状病变。目的:观察沙加地、特比萘芬软膏联合屈拉地内服治疗大癣的疗效。材料与方法:研究对象为60例大儒患者,分为两组(每组30例)。A组(干预组)给予Sarjadi Lepa Gutika局部用药2次/ d, Tiladi Churna 6gm /早餐后,连续30 d。B组(试验组)给予特比萘芬软膏局部应用2次,每日2次,早晨餐后服用地拉第6gm。每隔15天(第15天、第30天、第45天)记录一次评估。结果-两组在减少Kandu, Raaga和Manadala utpatti方面同样有效。结论:Sarjadi Lepa Gutika治疗体癣的疗效与特比萘芬药膏相当,与Tiladi Churna合用可预防体癣复发。
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引用次数: 0
Phytochemical and Physicochemical analysis of Siddha polyherbal formulation KaranthaiChooranam 悉达复方KaranthaiChooranam的植物化学和理化分析
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3312
S. M., N. G, Mohamed Mustafa M, S. Tr, Muthukumar Nj, M. V.
Aim: Standardization of a Siddha Poly herbal compound formulation is essential for establishing its authentication quantity and efficacy. In this present study, an attempt has been made to standardize the KaranthaiChooranam (a polyherbal formulation that contains 14 plant materials). Hence standardization of traditional drugs becomes highly essential to explore their potency and efficacy in the global market. It has been increasing public interest and acceptance of traditional medicine. Methods: Physico-Chemical analysis, Phyto-Chemical Screening, Particle Size, Pesticide Residue, and Sterility test were performed as per PLIM (Pharmacopeia Laboratory of Indian Medicine) guidelines. Results: The loss of drying of the tested drug was 105°c .KC contains 0.59% acid-insoluble ash and solubility in the water was 9.63 %. Phytochemical screening KC has shown the presence of Alkaloids, Glycosides, Saponins, Phytosterols, Fixed Oil, Resins, Phenols, Flavonoids and Tannins. Microscopic observation of the particle size analysis reveals that the average particle size of the sample was found to be 115.5 ± 42.83 μm. Conculsion: From this set of parameters, it can be concluded that it is sufficient to evaluate the authenticity of KaranthaiChooranam can be used as a reference standard for the preparation of the standardized pharmaceutical product and further quality content research. This study suggests that quality specifications of KC can be developed using parameters described in Siddha along with analytical tools available today.
目的:对悉达多复方制剂进行标准化,为确定其质量和疗效提供依据。在本研究中,我们尝试对KaranthaiChooranam(一种包含14种植物材料的多草药配方)进行标准化。因此,传统药物的标准化对于探索其在全球市场上的效力和功效至关重要。它提高了公众对传统医学的兴趣和接受程度。方法:理化分析、植物化学筛选、粒径、农药残留、无菌检验按印度药典实验室(PLIM)标准进行。结果:本品干燥损失为105℃,含酸不溶性灰分0.59%,水溶性9.63%。植物化学筛选KC显示存在生物碱、糖苷、皂苷、植物甾醇、固定油、树脂、酚类、黄酮类和单宁。显微观察粒度分析表明,样品的平均粒径为115.5±42.83 μm。结论:从这组参数可以得出,该参数足以对卡兰塔依胡拉南的真伪进行评价,可作为标准化药品制备及进一步质量含量研究的参考标准。这项研究表明,KC的质量规格可以使用Siddha中描述的参数以及今天可用的分析工具来开发。
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引用次数: 0
Bone healing efficacy of Lakshagrishtiksheeradi churna over Calcium +Vit D3 in Avrana Kanda Bhagna (Closed fractures of long bones) - A Randomized controlled clinical trial Lakshagrishtiksheeradi churna对Avrana Kanda Bhagna(长骨闭合性骨折)钙+维生素D3的骨愈合效果——一项随机对照临床试验
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3265
Shivay Gupta, Pradeep S. Shindhe, Amit Pingat, Ramesh S. Killedar
Background: Delayed bone healing or non-union of fractures owns high rate of complications, morbidity and mortality. It possesses enormous burden to both patients and healthcare system. Till now there is no proven molecule which could enhance the process of bone healing. Hence, time tested Lakshagrishtiksheeradi churna, an Ayurvedic formulation is explored for its efficacy in the management of Avrana Kanda Bhagna. Objective: To Evaluate Bone healing efficacy of Lakshagrishtiksheeradi churna in Avrana Kanda Bhagna. Methods: Total 30 patients meeting the inclusion criteria of Avrana Kanda Bhagna, with age group 14-50 years participated in the study. They were randomly divided into two groups. Group A received Lakshagrishtiksheeradi churna 6 grams and group B Tab Calcium 500 mg +VitD3 respectively twice a day for 30days. Assessments were done through various variables like Pain, Tenderness, Swelling and Bone callus index. Follow up visit was on 30th day and 45th day. Results: Study showed that both Lakshagrishtiksheeradi churna and Calcium + Vit D3 produced improvement in most of the variables and were comparable. However, marked improvements were seen in various variables like Pain, Tenderness, Swelling and Bone callus Index. Conclusion: Clinical efficacy showed that Lakshagrishtiksheeradi churna is safe, effective oral medication in the management of Avrana Kanda Bhagna (Closed Fractures of long bones).
背景:骨折延迟愈合或不愈合具有较高的并发症、发病率和死亡率。它给患者和医疗系统带来了巨大的负担。到目前为止,还没有证实的分子可以促进骨愈合的过程。因此,经过时间考验的lakshagrishtiksheradi churna,探索了阿育吠陀配方在管理阿芙拉纳Kanda Bhagna方面的功效。目的:评价阿夫拉纳·坎达巴纳拉克沙格里什克sheradi churna骨愈合的疗效。方法:30例符合Avrana Kanda Bhagna纳入标准的患者,年龄14 ~ 50岁。他们被随机分成两组。A组患者分别服用lakshagrishtiksheradi churna 6 g, B组患者分别服用钙片500 mg +维生素d3,每天2次,连用30天。通过疼痛、压痛、肿胀和骨痂指数等各种变量进行评估。随访时间分别为第30天和第45天。结果:研究表明,lakshagrishtiksheradi churna和钙+维生素D3在大多数变量上都有改善,并且具有可比性。然而,在疼痛、压痛、肿胀和骨痂指数等各种变量上都有明显的改善。结论:临床疗效表明,拉克沙格里提沙克是治疗闭合性长骨骨折安全、有效的口服药物。
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引用次数: 0
Determination of the association between excessive intake of Rasa and Retinal vascular changes in Pregnancy-Induced Hypertension- A Pilot Study 妊娠高血压患者Rasa过量摄入与视网膜血管变化相关性的初步研究
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3215
N. Pradhan, Pravin M. Bhat
Background: Pregnancy-induced hypertension (PIH) is a hypertensive disorder in pregnancy that occurs in the absence of other causes of elevated blood pressure. There are many complications documented for PIH and associated retinal vascular changes in one of them. During pregnancy if proper antenatal care along with diet is not followed, patient may land into complications like PIH related retinopathy. Aim: To determine the retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and excess intake of specific Rasa. Methods: All the patients admitted in ward with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria along with dietary habit were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed. Results: A total of 24 patients of PIH were examined. Majority were urban (75%) and remaining are from rural area (25%). The majority of patients are from 24-28 years age group followed by below 20 years age group. The gestation period ranged from 20 weeks to 38 weeks; 16 (66.6%) were primi gravida. Nineteen (79.1%) patients had mild preeclampsia, 03 (12.5%) had severe preeclampsia and 2 (8.33%) had eclampsia. Retinal changes (hypertensive retinopathy) were not seen in any of these patients Haemorrhages or exudates or retinal detachment were not seen in any patient. There was no association of retinal changes and Rasa Sevan a found in present pilot study. Conclusion: Retinal changes were not seen in any of the patients with PIH in present study sample and there was not found to be associated with excess intake of specific Rasa and severity of the disease. Fundus examination is necessary in assessment of the PIH patient.
背景:妊娠期高血压(PIH)是一种在没有其他原因导致血压升高的情况下发生的妊娠期高血压疾病。PIH有许多并发症,其中一例有相关的视网膜血管变化。在怀孕期间,如果不遵循适当的产前护理和饮食,患者可能会出现PIH相关视网膜病变等并发症。目的:确定妊娠高血压(PIH)患者的视网膜变化,以及视网膜变化与过量摄入特定Rasa之间的关系。方法:将所有确诊为妊高征的患者纳入本研究。病例记录中记录了年龄、种族、妊娠期、血压、蛋白尿以及饮食习惯。在记录任何眼部症状的病史后,在病房内用直接检眼镜扩瞳后进行眼底检查。所有的发现都记录在数据表上,并进行了分析。结果:共检查了24例妊高征患者。大多数是城市(75%),其余来自农村(25%)。大多数患者来自24-28岁年龄组,其次是20岁以下年龄组。妊娠期为20周到38周;初产妇16例(66.6%)。19名(79.1%)患者患有轻度先兆子痫,03名(12.5%)患者患有重度先兆子痫,2名(8.33%)患者患有子痫。这些患者中没有任何一例出现视网膜病变(高血压视网膜病变)。任何患者都没有出现出血或渗出物或视网膜脱离。在目前的初步研究中,视网膜变化和Rasa-Sevan a之间没有关联。结论:在本研究样本中,没有任何PIH患者出现视网膜变化,也没有发现与过量摄入特定Rasa和疾病严重程度有关。眼底检查是评估PIH患者的必要条件。
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引用次数: 0
A Critical Review on the Scope of Management of Academic Stress in Adolescents with Sattvavajaya Chikitsa (Ayurved Psychotherapy) 传统心理疗法治疗青少年学业压力的范围综述
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3258
V. Pandey, Renu Rathi, Shweta Pandey, Jitesh Verma
The adolescent stage of life is unique having various physical and psychological changes occurring in the body and in the brain. Academic stress (AS) is largely responsible for adolescents developing mental illnesses. A competitive environment, the pursuit of high scores in marks, peer comparisons, and parental expectations are the most common stressors for an adolescent to develop AS. Early identification of the stressed person, his sensitivity toward stress, and appropriate stress coping can help a person to develop the strength for coping with various stressful situations. Reports and articles published online from the year 1995 to 2022 were taken into account among them 95 articles were identified of which 25 articles had abstracts only were excluded and 70 articles including textbook references were reviewed and discussed. Ayurveda has the unique concept of Prakriti (~somatic constitution) helps a person to recognize himself and to realize his strengths and weaknesses, through which one can ignore or manage stressful situations. This stress coping can be more emphasized with the practice of Sattvavajaya Chikitsa(~Ayurvedic psychotherapy). Sattvavajaya Chikitsa works based on Manonigraha (control of the mind). Sadvrittta (~code of conduct for mental health), Swasthavritta (~measure to uplift general health), Achar Rasayana (~Ayurved code of conduct), Yoga, Surya Namaskar (~sun salutation), and meditation are different ways to practice mindfulness. Proper practice of Manonigraha (~control of mind) creates a connection between the mind, psyche, and body. The long-term practice of Manonighraha helps an academically stressed individual to better cope with stress and has finer mental and physical health. 
青少年的生命阶段是独特的,身体和大脑都会发生各种生理和心理变化。学业压力(AS)是青少年患精神疾病的主要原因。竞争环境、对高分的追求、同伴比较和父母的期望是青少年患AS最常见的压力源。早期识别压力大的人、他对压力的敏感性以及适当的压力应对可以帮助一个人培养应对各种压力情况的力量。考虑了1995年至2022年在线发表的报告和文章,其中确定了95篇文章,其中25篇只有摘要的文章被排除在外,70篇包括教科书参考文献的文章被审查和讨论。阿育吠陀有一个独特的概念,即Prakriti(身体体质)帮助一个人认识自己,并认识到自己的长处和短处,从而可以忽视或管理压力。这种压力应对可以通过Sattvavajaya Chikitsa(阿育吠陀心理治疗)的实践来更加强调。Sattvavajaya Chikitsa的作品基于Manonigraha(精神控制)。Sadvrittta(心理健康行为准则)、Swasthavritta(提升整体健康的措施)、Achar Rasayana(阿育吠陀行为准则),瑜伽、Surya Namaskar(向阳)和冥想是练习正念的不同方式。正确练习Manonigraha(控制心智)可以在心智、心理和身体之间建立联系。Manonighraha的长期实践有助于学业紧张的个人更好地应对压力,并拥有更好的身心健康。
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引用次数: 0
Evaluation of combined efficacy of Lodhradi lep with Khadirashtak kwath in Mukhdushika. 洛地乐普与卡地乐克联合治疗Mukhdushika的疗效评价。
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3307
M. Deshpande, Sadhana A. Kulkarni, A. Deshpande
Background - Mukhdushika (Acne vulgaris) is burning issue among young generation. It gives inferiority complex in social life. There are lots of medicines for acne vulgaris but the results are not upto the mark. Our aim is to combat with Mukhdushika with simple herbal formulation. Randomised controlled trial is preferred for the study. Methods – Aim:  To evaluate efficacy of combination of Lodhradilep and Khadirashtak kwath in management of Mukhdushika. Objectives: To study the Nidanpanchak of Mukhdushika as described in Ayurveda samhita To study the effect of combination of Lodhradi lep and Khadirashtak kwath.  Randomized control trial was conducted in two arms, Group A (Lodhradi lep) and Group B (Lodhradi lep with Khadirashtak kwath). 30 patients were selected randomly and Lodhradi lep was given for group A. 30 patients were selected randomly and Lodhradi lep with Khadirashtak kwath was given for group B. Result – The group B shown significant result in all the signs and symptoms. Discussion – The Z value was significant in all the objective criteria which shows Group B was more effective than group A in treating Mukhdushika. Keywords – Acne vulgaris, Kshudrarog, Khadirashtak kwath, Lep, Lodhradi lep, Mukhdushika
背景-寻常痤疮是年轻一代亟待解决的问题。它使人在社会生活中产生自卑情结。治疗寻常痤疮的药物很多,但效果都不理想。我们的目标是用简单的草药配方来对抗Mukhdushika。本研究首选随机对照试验。方法:目的:评价洛地拉西普与卡地拉西塔克合用治疗Mukhdushika的疗效。目的:研究《阿育吠陀典籍》中所描述的麝香草的内参,研究麝香草与麝香草合用的效果。随机对照试验分为两组,A组(Lodhradi lep)和B组(Lodhradi lep + Khadirashtak kwath)。随机选取30例患者给予Lodhradi lep作为a组,随机选取30例患者给予Lodhradi lep和Khadirashtak kwath作为B组。结果- B组所有体征和症状均有显著效果。讨论- Z值在所有客观标准中都很显著,这表明B组在治疗Mukhdushika方面比A组更有效。关键词:寻常痤疮,kshudarog, Khadirashtak kwath, Lep, Lodhradi Lep, Mukhdushika
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引用次数: 0
Comparative evaluation of Cranberry extract mouth rinse, Ozonized water and 0.2% Chlorhexidine on salivary Streptococcus mutans and Lactobacilli count: An in-vivo study 蔓越莓提取物漱口水、臭氧水和0.2%洗必定对唾液变形链球菌和乳酸杆菌计数的比较研究
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3366
P. Madhu, P. Gm, N. Pg, Sushanth Vh, Mohammed Imranulla, Vivek H
Background: Cariogenic bacteria has always been considered as the highest risk factor for dental caries. The eradication of microorganisms from the oral health environment is important and hence may remedies have been suggested for its removal for a better oral health. Objectives:  To assess the minimal inhibitory concentration (MIC) of  Cranberry extract and to determine the efficacy and compare the effect of the three products on salivary Streptococcus Mutans count and lactobacilli count.Materials and Methodology: A randomized control, double blind, parallel-group clinical trial was conducted on 75 subjects of age group of 15 years who were divided into three study groups ,Cranberry , Ozonized water and Chlorhexidine mouthwash. Microbial analysis was done by colony counter unit at baseline, 8thday and 15th day of using the mouthwashes. The inter-group variations was analyzed by using One way ANOVA followed by Tukey’s post hoc and Repeated measures for intra-group variations at different time intervals. Results: Streptococcus mutans and Lactobacilli colony count showed a statistically highly significant difference in reduction of colony count between the three groups (p=0.001) at 8th and 15th day of using the mouthwashes. Ozonized water showed better reduction when compared with Cranberry mouth wash in reduction of Streptococcus mutans count. Cranberry mouth wash had shown a better reduction when compared with Ozonized water in reduction of Lactobacilli colony count.Conclusion: The test mouthwash was effective in reducing the microbial count, similar to Chlorhexidine mouth wash. Recent advances may allow the dental community to be exposed to much better oral health care. key words : cranberry, ozone water, streptococcus mutans, lacto bacilli, oral hygiene
背景:致龋细菌一直被认为是龋齿的最高危险因素。从口腔健康环境中根除微生物是重要的,因此可能已经提出了去除微生物以改善口腔健康的补救措施。目的:评价蔓越莓提取物的最低抑菌浓度(MIC),测定三种产品对唾液变形链球菌计数和乳酸杆菌计数的疗效并比较其效果。材料和方法:对75名15岁年龄组的受试者进行随机对照、双盲、平行组临床试验,他们被分为三个研究组,即蔓越莓、臭氧水和氯己定漱口水。在基线、使用漱口水的第8天和第15天使用菌落计数器进行微生物分析。通过使用单向ANOVA分析组间变异,然后对不同时间间隔的组内变异进行Tukey的事后和重复测量。结果:在使用漱口水的第8天和第15天,变形链球菌和乳酸杆菌菌落计数在三组之间的菌落计数减少方面显示出统计学上的高度显著差异(p=0.001)。与蔓越莓漱口液相比,臭氧水在减少变形链球菌计数方面表现出更好的减少效果。与臭氧水相比,蔓越莓漱口液在减少乳酸杆菌菌落计数方面表现出更好的减少效果。结论:与氯己定漱口液类似,该测试漱口水在降低微生物计数方面是有效的。最近的进展可能使牙科社区能够获得更好的口腔保健。关键词:蔓越莓、臭氧水、变形链球菌、乳酸杆菌、口腔卫生
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引用次数: 0
Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation Vitex Negundo抗炎中药凝胶增强渗透性的优化与评价
IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-04-04 DOI: 10.47552/ijam.v14i1.3263
K. M., A. Dubey, Manohar Mahadev, A. Shetty
The use of conventional drugs for the treatment of pain and inflammation has largely resulted in various side effects. These challenges have triggered the search for alternative therapy such as herbal medication that may serve as a safe, effective, and alternate treatment approach to managing pain and inflammation. Vitex negundo, a potential lipophilic molecule, possesses limited solubility and permeability. Emulgels are either water-in-oil or oil-in-water type emulsions, mixed with a gelling agent to form a gel for the delivery of lipophilic active ingredients. Therefore the current study is undertaken for the effective delivery of vitex negundo locally in the form of oil-in-water emulgel for improving solubility and permeability. The emulgel was formulated from carbopol 934 with vitex negundo in mineral oil emulsion using tween 80 (surfactant), and triethanolamine (co-surfactant). The formulations were optimized using the design of experiment software. The optimized emulgel formulation containing Smix (tween 80 and triethanolamine) ratio of 61.90, mineral oil 50.58%, and carbopol 934 3% showed a pH of 6.5±0.3, a viscosity of 17793 – 939 cps, and spreadability of 7.07 g.cm/s. Data from in-vitro and ex-vivo diffusion studies demonstrated improved permeability properties. The stability of the optimized emulgel formulation was additionally examined at ambient temperature for 28 days. The emulgel remained stable for 28 days. Based on the overall results we can conclude that emulgel can be a promising and suitable formulation for the application of vitex negundo.
使用传统药物治疗疼痛和炎症在很大程度上导致了各种副作用。这些挑战促使人们寻找替代疗法,如草药,以作为一种安全、有效和替代的治疗方法来控制疼痛和炎症。黄荆是一种潜在的亲脂分子,具有有限的溶解度和渗透性。乳液是油包水或油包水型乳液,与胶凝剂混合形成用于输送亲脂活性成分的凝胶。因此,为了提高溶解度和渗透率,本研究以水包油凝胶的形式有效地局部输送荆荆。以卡波醇934和牡荆果为原料,在矿物油乳液中,用吐温80(表面活性剂)和三乙醇胺(助表面活性剂)配制乳液。利用实验软件设计对配方进行优化。以Smix(80 /三乙醇胺)比为61.90,矿物油为50.58%,卡泊酚为934 3%为优化配方,其pH为6.5±0.3,粘度为17793 ~ 939 cps,涂胶性能为7.07 g.cm/s。体外和离体扩散研究的数据表明,其渗透性得到了改善。并在室温下对优化后的乳状液配方进行了28天的稳定性考察。凝胶在28天内保持稳定。综上所述,乳凝胶是一种很有前途的、适合于黄荆应用的制剂。
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International Journal of Ayurvedic Medicine
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