Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3327
Iliyasu Zanna, Y. Ibrahim, I. Nasir, M. Attah
Objective: The use of ethnobiology in treatment of many diseases especially in rural residents with limited access to medical technology, treatment and equipment is beneficial and necessary. Daucus carota (DC) root extract was used as pre-treatment in adult Wistar rats exposed to diclofenac sodium (DF) to investigate a protective effect on the histology of liver, kidney and duodenum. Materials and Method: Twenty-five adult Wistar rats were used for this study and were randomly divided into 5 groups of 5 rats each, which included: Group A - Normal control; Group B – 50mg/kg DF control; Group C – 50mg/kg DC + 50mg/kg DF, Group D – 100mg/kg DC + 50mg/kg DF; and, Group E – 140mg/kg DC + 50mg/kg DC. Results and Discussion: The results showed a reduction in damage to the hepatocytes, maintenance of sinusoidal integrity and reduction in the number of inflammatory cells in the hepatic parenchyma, In the kidney tissue, the extract preserved the glomerular capillary tuft, renal tubular epithelial cells, conserved Bowman’s space and lining epithelium of the capsule in a dose dependent manner. The intestinal mucosa in groups treated with higher doses of the extract were completely preserved and intact with minimal erosion of epithelial lining along with preservation of lamina propria and intestinal glands. Conclusion: Pre-administration of DC, preferably at concentrations of 100mg/kg and 140mg/kg reduced hepatotoxicity, renal tissue and mucosal layer damage in the duodenum following administration of DF. This preservation of tissues improved as concentration of the extract increased verifying that its efficiency was dose dependent.
目的：利用民族生物学治疗许多疾病，特别是在获得医疗技术、治疗和设备有限的农村居民中，是有益和必要的。采用颈豆根提取物对暴露于双氯芬酸钠（DF）的成年Wistar大鼠进行预处理，研究其对肝、肾和十二指肠组织学的保护作用。材料与方法：本研究选用成年Wistar大鼠25只，随机分为5组，每组5只，包括：A组-正常对照组；B组50mg/kg DF对照组；C组–50mg/kg DC + 50mg/kg DF，D组–100mg/kg DC + 50mg/kg DF；E组为140mg/kg DC+50mg/kg DC。结果与讨论：结果显示，肝细胞损伤减少，肝实质中正弦完整性得到维持，炎症细胞数量减少。在肾组织中，提取物以剂量依赖的方式保留了肾小球毛细血管簇、肾小管上皮细胞、鲍曼间隙和包膜衬里上皮。用高剂量提取物处理的组的肠粘膜得到了完全保存和完整，上皮衬里的侵蚀最小，固有层和肠腺也得到了保存。结论：DC预给药，最好是100mg/kg和140mg/kg的浓度，可以降低DF给药后的肝毒性、肾组织和十二指肠粘膜层损伤。这种组织保存随着提取物浓度的增加而改善，验证了其效率是剂量依赖性的。
{"title":"Aqueous extract of Daucus carota exerts a protective effect on the Renal, Hepatic and Duodenal mucosal histology in Diclofenac Induced Tissue Injury","authors":"Iliyasu Zanna, Y. Ibrahim, I. Nasir, M. Attah","doi":"10.47552/ijam.v14i1.3327","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3327","url":null,"abstract":"Objective: The use of ethnobiology in treatment of many diseases especially in rural residents with limited access to medical technology, treatment and equipment is beneficial and necessary. Daucus carota (DC) root extract was used as pre-treatment in adult Wistar rats exposed to diclofenac sodium (DF) to investigate a protective effect on the histology of liver, kidney and duodenum. Materials and Method: Twenty-five adult Wistar rats were used for this study and were randomly divided into 5 groups of 5 rats each, which included: Group A - Normal control; Group B – 50mg/kg DF control; Group C – 50mg/kg DC + 50mg/kg DF, Group D – 100mg/kg DC + 50mg/kg DF; and, Group E – 140mg/kg DC + 50mg/kg DC. Results and Discussion: The results showed a reduction in damage to the hepatocytes, maintenance of sinusoidal integrity and reduction in the number of inflammatory cells in the hepatic parenchyma, In the kidney tissue, the extract preserved the glomerular capillary tuft, renal tubular epithelial cells, conserved Bowman’s space and lining epithelium of the capsule in a dose dependent manner. The intestinal mucosa in groups treated with higher doses of the extract were completely preserved and intact with minimal erosion of epithelial lining along with preservation of lamina propria and intestinal glands. Conclusion: Pre-administration of DC, preferably at concentrations of 100mg/kg and 140mg/kg reduced hepatotoxicity, renal tissue and mucosal layer damage in the duodenum following administration of DF. This preservation of tissues improved as concentration of the extract increased verifying that its efficiency was dose dependent. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44916539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.2289
G. Prasad, P. Goli, Mohd. Kashif Husain, S. Prasad, A. Gurav, Srikanth Narayanam
Aim and Objective: To unveil and document the folklore claims and dietary recipes of Bambusa bambos and Dendrocalamus strictus. Materials and methods: The study was intended to examine the 101 tribal individuals like traditional healers, tribal doctors and elder people in the field trips on their regular utilization of different species of Bamboo. Results: The study explored 13 contemporary folklore claims on B. bambos and D. strictus species solicited from various tribal pockets of Chittoor District, Andhra Pradesh and dietary recipes from the tribes of West Godavari and East Godavari districts, Andhra Pradesh. Conclusion: With this study, it can be concluded that various parts of Bambusa bambos and Dendrocalamus strictus are practiced as conventional drugs to treat different ailments by local tribes and conventional healers from Chittoor district, Andhra Pradesh. Besides this, the young shoots of Bambusa bambos are a fabulous dietary hotspot for several minerals. This recipe of Bamboo shoots has been in permanence among the tribes of West Godavari and East Godavari districts for the past several generations. Ayurveda has also validated this fact owing to its therapeutic properties. By all its nutritive potential, it can be determined that it is not only good to the taste receptors but also healthy.
{"title":"Ethnobotanical and dietary uses of Bamboo unveiled by the tribes and local inhabitants of Chittoor district, West Godavari and East Godavari districts of Andhra Pradesh","authors":"G. Prasad, P. Goli, Mohd. Kashif Husain, S. Prasad, A. Gurav, Srikanth Narayanam","doi":"10.47552/ijam.v14i1.2289","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.2289","url":null,"abstract":"Aim and Objective: To unveil and document the folklore claims and dietary recipes of Bambusa bambos and Dendrocalamus strictus. \u0000Materials and methods: The study was intended to examine the 101 tribal individuals like traditional healers, tribal doctors and elder people in the field trips on their regular utilization of different species of Bamboo. \u0000Results: The study explored 13 contemporary folklore claims on B. bambos and D. strictus species solicited from various tribal pockets of Chittoor District, Andhra Pradesh and dietary recipes from the tribes of West Godavari and East Godavari districts, Andhra Pradesh. \u0000Conclusion: With this study, it can be concluded that various parts of Bambusa bambos and Dendrocalamus strictus are practiced as conventional drugs to treat different ailments by local tribes and conventional healers from Chittoor district, Andhra Pradesh. Besides this, the young shoots of Bambusa bambos are a fabulous dietary hotspot for several minerals. This recipe of Bamboo shoots has been in permanence among the tribes of West Godavari and East Godavari districts for the past several generations. Ayurveda has also validated this fact owing to its therapeutic properties. By all its nutritive potential, it can be determined that it is not only good to the taste receptors but also healthy.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42582717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3223
Sonam Agrawal, Aparna Singh, S. Gehlot
Bala in Ayurveda physiology is a multidimensional factor that refers to physical and psychological strength and the ability produced in response to antigen exposure and resistance against the manifestation of disease. It has also been synonymously used for components providing strength, nourishment, and stability to the body such as Oja, Vyadhikshamatva, Balya, Sara, Balavriddhikara Bhava, Prakrita Sleshma. The Bala of a person is determined by a complex interaction of multifactor such as Balavriddhikara Bhava, Dhatu Sarata, Prakriti, indulgence in dietary and behavioural activities, inherent qualities, etc. Further, it has also been opined that the Bala of a person cannot be assessed by just observing his body physique, as it has been seen that a person having a well-formed body does not always have good strength. In contrast, a person with a lean body may have excellent stability. As the Bala of a person serves as an important criterion for assessment of the severity as well as prognosis of disease, there is a need for the development of objective parameters for its assessment and implication in clinical practices.
{"title":"A narrative review on concept of Bala and immunity in Ayurveda physiology","authors":"Sonam Agrawal, Aparna Singh, S. Gehlot","doi":"10.47552/ijam.v14i1.3223","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3223","url":null,"abstract":"Bala in Ayurveda physiology is a multidimensional factor that refers to physical and psychological strength and the ability produced in response to antigen exposure and resistance against the manifestation of disease. It has also been synonymously used for components providing strength, nourishment, and stability to the body such as Oja, Vyadhikshamatva, Balya, Sara, Balavriddhikara Bhava, Prakrita Sleshma. The Bala of a person is determined by a complex interaction of multifactor such as Balavriddhikara Bhava, Dhatu Sarata, Prakriti, indulgence in dietary and behavioural activities, inherent qualities, etc. Further, it has also been opined that the Bala of a person cannot be assessed by just observing his body physique, as it has been seen that a person having a well-formed body does not always have good strength. In contrast, a person with a lean body may have excellent stability. As the Bala of a person serves as an important criterion for assessment of the severity as well as prognosis of disease, there is a need for the development of objective parameters for its assessment and implication in clinical practices. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45262395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3258
V. Pandey, Renu Rathi, Shweta Pandey, Jitesh Verma
The adolescent stage of life is unique having various physical and psychological changes occurring in the body and in the brain. Academic stress (AS) is largely responsible for adolescents developing mental illnesses. A competitive environment, the pursuit of high scores in marks, peer comparisons, and parental expectations are the most common stressors for an adolescent to develop AS. Early identification of the stressed person, his sensitivity toward stress, and appropriate stress coping can help a person to develop the strength for coping with various stressful situations. Reports and articles published online from the year 1995 to 2022 were taken into account among them 95 articles were identified of which 25 articles had abstracts only were excluded and 70 articles including textbook references were reviewed and discussed. Ayurveda has the unique concept of Prakriti (~somatic constitution) helps a person to recognize himself and to realize his strengths and weaknesses, through which one can ignore or manage stressful situations. This stress coping can be more emphasized with the practice of Sattvavajaya Chikitsa(~Ayurvedic psychotherapy). Sattvavajaya Chikitsa works based on Manonigraha (control of the mind). Sadvrittta (~code of conduct for mental health), Swasthavritta (~measure to uplift general health), Achar Rasayana (~Ayurved code of conduct), Yoga, Surya Namaskar (~sun salutation), and meditation are different ways to practice mindfulness. Proper practice of Manonigraha (~control of mind) creates a connection between the mind, psyche, and body. The long-term practice of Manonighraha helps an academically stressed individual to better cope with stress and has finer mental and physical health.
{"title":"A Critical Review on the Scope of Management of Academic Stress in Adolescents with Sattvavajaya Chikitsa (Ayurved Psychotherapy)","authors":"V. Pandey, Renu Rathi, Shweta Pandey, Jitesh Verma","doi":"10.47552/ijam.v14i1.3258","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3258","url":null,"abstract":"The adolescent stage of life is unique having various physical and psychological changes occurring in the body and in the brain. Academic stress (AS) is largely responsible for adolescents developing mental illnesses. A competitive environment, the pursuit of high scores in marks, peer comparisons, and parental expectations are the most common stressors for an adolescent to develop AS. Early identification of the stressed person, his sensitivity toward stress, and appropriate stress coping can help a person to develop the strength for coping with various stressful situations. Reports and articles published online from the year 1995 to 2022 were taken into account among them 95 articles were identified of which 25 articles had abstracts only were excluded and 70 articles including textbook references were reviewed and discussed. Ayurveda has the unique concept of Prakriti (~somatic constitution) helps a person to recognize himself and to realize his strengths and weaknesses, through which one can ignore or manage stressful situations. This stress coping can be more emphasized with the practice of Sattvavajaya Chikitsa(~Ayurvedic psychotherapy). Sattvavajaya Chikitsa works based on Manonigraha (control of the mind). Sadvrittta (~code of conduct for mental health), Swasthavritta (~measure to uplift general health), Achar Rasayana (~Ayurved code of conduct), Yoga, Surya Namaskar (~sun salutation), and meditation are different ways to practice mindfulness. Proper practice of Manonigraha (~control of mind) creates a connection between the mind, psyche, and body. The long-term practice of Manonighraha helps an academically stressed individual to better cope with stress and has finer mental and physical health. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45002219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3368
Jassim Rahiman K, Singh Op
Cancer is a leading cause of mortality worldwide; however advanced medical diagnostic techniques and medical interventions reduced the mortality considerably. But adverse effects due to chemotherapy decreased the quality of life, Chemotherapy induced peripheral neuropathy (CIPN) is such entity as till now no established treatment protocol is not available. Hence, alternative methods of preventing or treating CIPN are necessary. Many studies found that herbal medicines showed potentially beneficial effects on CIPN. Treatment modalities in ayurvedic science should be given to the CIPN and to assess the effectiveness of herbal medicines for CIPN, a systematic review and study is essential in ayurveda to treat Chemotherapy Induced Peripheral Neuropathy. CIPN most commonly presents as a pure sensory neuropathy with symmetric symptoms typically including numbness, loss of proprioception sense, tingling, pins and needles sensation, hyperalgesia or allodynia in the hands or feet in a stocking-glove distribution. Occasionally there can be damage to motor fibers resulting in a motor neuropathy. Autonomic neuropathy can be associated with orthostatic hypotension, severe constipation and erectile dysfunction. In ayurveda symptomatology it can be corelated to Aganthuja vata-pitta vikara having alpa-bala-ojokshaya condition. In cancer there is much much reduced Oja, and bala chemotherapy having properties of visha guna and vata-pitta vitiation causes dhatu, upadhatu, mala and indiriya pradoshaja vikara with predominance of vata nature like Gatrasuptata (~numbness), Spandanam (~twitching sensation), Bheda (~splitting pain), Toda (~Excrutiating pain) and Pitta nature like Daha (~burning sensation), osha (~heat feel), Plosha (~Scorching), Dhoomaka (~fuming feel). Moreover, these symptoms are described in vataja nanatmaja and pittaja nanatmaja vikaras.
{"title":"A Literary review on Chemotherapy Induced Peripheral Neuropathy (CIPN) - An Ayurveda approach","authors":"Jassim Rahiman K, Singh Op","doi":"10.47552/ijam.v14i1.3368","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3368","url":null,"abstract":"Cancer is a leading cause of mortality worldwide; however advanced medical diagnostic techniques and medical interventions reduced the mortality considerably. But adverse effects due to chemotherapy decreased the quality of life, Chemotherapy induced peripheral neuropathy (CIPN) is such entity as till now no established treatment protocol is not available. Hence, alternative methods of preventing or treating CIPN are necessary. Many studies found that herbal medicines showed potentially beneficial effects on CIPN. Treatment modalities in ayurvedic science should be given to the CIPN and to assess the effectiveness of herbal medicines for CIPN, a systematic review and study is essential in ayurveda to treat Chemotherapy Induced Peripheral Neuropathy. CIPN most commonly presents as a pure sensory neuropathy with symmetric symptoms typically including numbness, loss of proprioception sense, tingling, pins and needles sensation, hyperalgesia or allodynia in the hands or feet in a stocking-glove distribution. Occasionally there can be damage to motor fibers resulting in a motor neuropathy. Autonomic neuropathy can be associated with orthostatic hypotension, severe constipation and erectile dysfunction. In ayurveda symptomatology it can be corelated to Aganthuja vata-pitta vikara having alpa-bala-ojokshaya condition. In cancer there is much much reduced Oja, and bala chemotherapy having properties of visha guna and vata-pitta vitiation causes dhatu, upadhatu, mala and indiriya pradoshaja vikara with predominance of vata nature like Gatrasuptata (~numbness), Spandanam (~twitching sensation), Bheda (~splitting pain), Toda (~Excrutiating pain) and Pitta nature like Daha (~burning sensation), osha (~heat feel), Plosha (~Scorching), Dhoomaka (~fuming feel). Moreover, these symptoms are described in vataja nanatmaja and pittaja nanatmaja vikaras.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45216726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3366
P. Madhu, P. Gm, N. Pg, Sushanth Vh, Mohammed Imranulla, Vivek H
Background: Cariogenic bacteria has always been considered as the highest risk factor for dental caries. The eradication of microorganisms from the oral health environment is important and hence may remedies have been suggested for its removal for a better oral health. Objectives: To assess the minimal inhibitory concentration (MIC) of Cranberry extract and to determine the efficacy and compare the effect of the three products on salivary Streptococcus Mutans count and lactobacilli count.Materials and Methodology: A randomized control, double blind, parallel-group clinical trial was conducted on 75 subjects of age group of 15 years who were divided into three study groups ,Cranberry , Ozonized water and Chlorhexidine mouthwash. Microbial analysis was done by colony counter unit at baseline, 8thday and 15th day of using the mouthwashes. The inter-group variations was analyzed by using One way ANOVA followed by Tukey’s post hoc and Repeated measures for intra-group variations at different time intervals. Results: Streptococcus mutans and Lactobacilli colony count showed a statistically highly significant difference in reduction of colony count between the three groups (p=0.001) at 8th and 15th day of using the mouthwashes. Ozonized water showed better reduction when compared with Cranberry mouth wash in reduction of Streptococcus mutans count. Cranberry mouth wash had shown a better reduction when compared with Ozonized water in reduction of Lactobacilli colony count.Conclusion: The test mouthwash was effective in reducing the microbial count, similar to Chlorhexidine mouth wash. Recent advances may allow the dental community to be exposed to much better oral health care. key words : cranberry, ozone water, streptococcus mutans, lacto bacilli, oral hygiene
{"title":"Comparative evaluation of Cranberry extract mouth rinse, Ozonized water and 0.2% Chlorhexidine on salivary Streptococcus mutans and Lactobacilli count: An in-vivo study","authors":"P. Madhu, P. Gm, N. Pg, Sushanth Vh, Mohammed Imranulla, Vivek H","doi":"10.47552/ijam.v14i1.3366","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3366","url":null,"abstract":"Background: Cariogenic bacteria has always been considered as the highest risk factor for dental caries. The eradication of microorganisms from the oral health environment is important and hence may remedies have been suggested for its removal for a better oral health. \u0000Objectives: To assess the minimal inhibitory concentration (MIC) of Cranberry extract and to determine the efficacy and compare the effect of the three products on salivary Streptococcus Mutans count and lactobacilli count.Materials and Methodology: A randomized control, double blind, parallel-group clinical trial was conducted on 75 subjects of age group of 15 years who were divided into three study groups ,Cranberry , Ozonized water and Chlorhexidine mouthwash. Microbial analysis was done by colony counter unit at baseline, 8thday and 15th day of using the mouthwashes. The inter-group variations was analyzed by using One way ANOVA followed by Tukey’s post hoc and Repeated measures for intra-group variations at different time intervals. \u0000Results: Streptococcus mutans and Lactobacilli colony count showed a statistically highly significant difference in reduction of colony count between the three groups (p=0.001) at 8th and 15th day of using the mouthwashes. Ozonized water showed better reduction when compared with Cranberry mouth wash in reduction of Streptococcus mutans count. Cranberry mouth wash had shown a better reduction when compared with Ozonized water in reduction of Lactobacilli colony count.Conclusion: The test mouthwash was effective in reducing the microbial count, similar to Chlorhexidine mouth wash. Recent advances may allow the dental community to be exposed to much better oral health care. \u0000key words : cranberry, ozone water, streptococcus mutans, lacto bacilli, oral hygiene","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43264532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3263
K. M., A. Dubey, Manohar Mahadev, A. Shetty
The use of conventional drugs for the treatment of pain and inflammation has largely resulted in various side effects. These challenges have triggered the search for alternative therapy such as herbal medication that may serve as a safe, effective, and alternate treatment approach to managing pain and inflammation. Vitex negundo, a potential lipophilic molecule, possesses limited solubility and permeability. Emulgels are either water-in-oil or oil-in-water type emulsions, mixed with a gelling agent to form a gel for the delivery of lipophilic active ingredients. Therefore the current study is undertaken for the effective delivery of vitex negundo locally in the form of oil-in-water emulgel for improving solubility and permeability. The emulgel was formulated from carbopol 934 with vitex negundo in mineral oil emulsion using tween 80 (surfactant), and triethanolamine (co-surfactant). The formulations were optimized using the design of experiment software. The optimized emulgel formulation containing Smix (tween 80 and triethanolamine) ratio of 61.90, mineral oil 50.58%, and carbopol 934 3% showed a pH of 6.5±0.3, a viscosity of 17793 – 939 cps, and spreadability of 7.07 g.cm/s. Data from in-vitro and ex-vivo diffusion studies demonstrated improved permeability properties. The stability of the optimized emulgel formulation was additionally examined at ambient temperature for 28 days. The emulgel remained stable for 28 days. Based on the overall results we can conclude that emulgel can be a promising and suitable formulation for the application of vitex negundo.
{"title":"Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation","authors":"K. M., A. Dubey, Manohar Mahadev, A. Shetty","doi":"10.47552/ijam.v14i1.3263","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3263","url":null,"abstract":"The use of conventional drugs for the treatment of pain and inflammation has largely resulted in various side effects. These challenges have triggered the search for alternative therapy such as herbal medication that may serve as a safe, effective, and alternate treatment approach to managing pain and inflammation. Vitex negundo, a potential lipophilic molecule, possesses limited solubility and permeability. Emulgels are either water-in-oil or oil-in-water type emulsions, mixed with a gelling agent to form a gel for the delivery of lipophilic active ingredients. Therefore the current study is undertaken for the effective delivery of vitex negundo locally in the form of oil-in-water emulgel for improving solubility and permeability. The emulgel was formulated from carbopol 934 with vitex negundo in mineral oil emulsion using tween 80 (surfactant), and triethanolamine (co-surfactant). The formulations were optimized using the design of experiment software. The optimized emulgel formulation containing Smix (tween 80 and triethanolamine) ratio of 61.90, mineral oil 50.58%, and carbopol 934 3% showed a pH of 6.5±0.3, a viscosity of 17793 – 939 cps, and spreadability of 7.07 g.cm/s. Data from in-vitro and ex-vivo diffusion studies demonstrated improved permeability properties. The stability of the optimized emulgel formulation was additionally examined at ambient temperature for 28 days. The emulgel remained stable for 28 days. Based on the overall results we can conclude that emulgel can be a promising and suitable formulation for the application of vitex negundo.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46743748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3265
Shivay Gupta, Pradeep S. Shindhe, Amit Pingat, Ramesh S. Killedar
Background: Delayed bone healing or non-union of fractures owns high rate of complications, morbidity and mortality. It possesses enormous burden to both patients and healthcare system. Till now there is no proven molecule which could enhance the process of bone healing. Hence, time tested Lakshagrishtiksheeradi churna, an Ayurvedic formulation is explored for its efficacy in the management of Avrana Kanda Bhagna. Objective: To Evaluate Bone healing efficacy of Lakshagrishtiksheeradi churna in Avrana Kanda Bhagna. Methods: Total 30 patients meeting the inclusion criteria of Avrana Kanda Bhagna, with age group 14-50 years participated in the study. They were randomly divided into two groups. Group A received Lakshagrishtiksheeradi churna 6 grams and group B Tab Calcium 500 mg +VitD3 respectively twice a day for 30days. Assessments were done through various variables like Pain, Tenderness, Swelling and Bone callus index. Follow up visit was on 30th day and 45th day. Results: Study showed that both Lakshagrishtiksheeradi churna and Calcium + Vit D3 produced improvement in most of the variables and were comparable. However, marked improvements were seen in various variables like Pain, Tenderness, Swelling and Bone callus Index. Conclusion: Clinical efficacy showed that Lakshagrishtiksheeradi churna is safe, effective oral medication in the management of Avrana Kanda Bhagna (Closed Fractures of long bones).
{"title":"Bone healing efficacy of Lakshagrishtiksheeradi churna over Calcium +Vit D3 in Avrana Kanda Bhagna (Closed fractures of long bones) - A Randomized controlled clinical trial","authors":"Shivay Gupta, Pradeep S. Shindhe, Amit Pingat, Ramesh S. Killedar","doi":"10.47552/ijam.v14i1.3265","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3265","url":null,"abstract":"Background: Delayed bone healing or non-union of fractures owns high rate of complications, morbidity and mortality. It possesses enormous burden to both patients and healthcare system. Till now there is no proven molecule which could enhance the process of bone healing. Hence, time tested Lakshagrishtiksheeradi churna, an Ayurvedic formulation is explored for its efficacy in the management of Avrana Kanda Bhagna. Objective: To Evaluate Bone healing efficacy of Lakshagrishtiksheeradi churna in Avrana Kanda Bhagna. Methods: Total 30 patients meeting the inclusion criteria of Avrana Kanda Bhagna, with age group 14-50 years participated in the study. They were randomly divided into two groups. Group A received Lakshagrishtiksheeradi churna 6 grams and group B Tab Calcium 500 mg +VitD3 respectively twice a day for 30days. Assessments were done through various variables like Pain, Tenderness, Swelling and Bone callus index. Follow up visit was on 30th day and 45th day. Results: Study showed that both Lakshagrishtiksheeradi churna and Calcium + Vit D3 produced improvement in most of the variables and were comparable. However, marked improvements were seen in various variables like Pain, Tenderness, Swelling and Bone callus Index. Conclusion: Clinical efficacy showed that Lakshagrishtiksheeradi churna is safe, effective oral medication in the management of Avrana Kanda Bhagna (Closed Fractures of long bones).","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42946104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3307
M. Deshpande, Sadhana A. Kulkarni, A. Deshpande
Background - Mukhdushika (Acne vulgaris) is burning issue among young generation. It gives inferiority complex in social life. There are lots of medicines for acne vulgaris but the results are not upto the mark. Our aim is to combat with Mukhdushika with simple herbal formulation. Randomised controlled trial is preferred for the study. Methods – Aim: To evaluate efficacy of combination of Lodhradilep and Khadirashtak kwath in management of Mukhdushika. Objectives: To study the Nidanpanchak of Mukhdushika as described in Ayurveda samhita To study the effect of combination of Lodhradi lep and Khadirashtak kwath. Randomized control trial was conducted in two arms, Group A (Lodhradi lep) and Group B (Lodhradi lep with Khadirashtak kwath). 30 patients were selected randomly and Lodhradi lep was given for group A. 30 patients were selected randomly and Lodhradi lep with Khadirashtak kwath was given for group B. Result – The group B shown significant result in all the signs and symptoms. Discussion – The Z value was significant in all the objective criteria which shows Group B was more effective than group A in treating Mukhdushika. Keywords – Acne vulgaris, Kshudrarog, Khadirashtak kwath, Lep, Lodhradi lep, Mukhdushika
{"title":"Evaluation of combined efficacy of Lodhradi lep with Khadirashtak kwath in Mukhdushika.","authors":"M. Deshpande, Sadhana A. Kulkarni, A. Deshpande","doi":"10.47552/ijam.v14i1.3307","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3307","url":null,"abstract":"Background - Mukhdushika (Acne vulgaris) is burning issue among young generation. It gives inferiority complex in social life. There are lots of medicines for acne vulgaris but the results are not upto the mark. Our aim is to combat with Mukhdushika with simple herbal formulation. Randomised controlled trial is preferred for the study. \u0000Methods – Aim: To evaluate efficacy of combination of Lodhradilep and Khadirashtak kwath in management of Mukhdushika. \u0000Objectives: \u0000 \u0000To study the Nidanpanchak of Mukhdushika as described in Ayurveda samhita \u0000To study the effect of combination of Lodhradi lep and Khadirashtak kwath. \u0000 \u0000Randomized control trial was conducted in two arms, Group A (Lodhradi lep) and Group B (Lodhradi lep with Khadirashtak kwath). 30 patients were selected randomly and Lodhradi lep was given for group A. 30 patients were selected randomly and Lodhradi lep with Khadirashtak kwath was given for group B. \u0000Result – The group B shown significant result in all the signs and symptoms. \u0000Discussion – The Z value was significant in all the objective criteria which shows Group B was more effective than group A in treating Mukhdushika. \u0000Keywords – Acne vulgaris, Kshudrarog, Khadirashtak kwath, Lep, Lodhradi lep, Mukhdushika","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43957941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3215
N. Pradhan, Pravin M. Bhat
Background: Pregnancy-induced hypertension (PIH) is a hypertensive disorder in pregnancy that occurs in the absence of other causes of elevated blood pressure. There are many complications documented for PIH and associated retinal vascular changes in one of them. During pregnancy if proper antenatal care along with diet is not followed, patient may land into complications like PIH related retinopathy. Aim: To determine the retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and excess intake of specific Rasa. Methods: All the patients admitted in ward with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria along with dietary habit were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed. Results: A total of 24 patients of PIH were examined. Majority were urban (75%) and remaining are from rural area (25%). The majority of patients are from 24-28 years age group followed by below 20 years age group. The gestation period ranged from 20 weeks to 38 weeks; 16 (66.6%) were primi gravida. Nineteen (79.1%) patients had mild preeclampsia, 03 (12.5%) had severe preeclampsia and 2 (8.33%) had eclampsia. Retinal changes (hypertensive retinopathy) were not seen in any of these patients Haemorrhages or exudates or retinal detachment were not seen in any patient. There was no association of retinal changes and Rasa Sevan a found in present pilot study. Conclusion: Retinal changes were not seen in any of the patients with PIH in present study sample and there was not found to be associated with excess intake of specific Rasa and severity of the disease. Fundus examination is necessary in assessment of the PIH patient.
{"title":"Determination of the association between excessive intake of Rasa and Retinal vascular changes in Pregnancy-Induced Hypertension- A Pilot Study","authors":"N. Pradhan, Pravin M. Bhat","doi":"10.47552/ijam.v14i1.3215","DOIUrl":"https://doi.org/10.47552/ijam.v14i1.3215","url":null,"abstract":"Background: Pregnancy-induced hypertension (PIH) is a hypertensive disorder in pregnancy that occurs in the absence of other causes of elevated blood pressure. There are many complications documented for PIH and associated retinal vascular changes in one of them. During pregnancy if proper antenatal care along with diet is not followed, patient may land into complications like PIH related retinopathy. Aim: To determine the retinal changes in pregnancy induced hypertension (PIH) and any association between the retinal changes and excess intake of specific Rasa. Methods: All the patients admitted in ward with diagnosis of PIH were included in this study. Age, race, gravida, gestation period, blood pressure, and proteinuria along with dietary habit were noted from the case records. After taking history for any eye symptoms, fundus examination was done after dilating the pupils with direct ophthalmoscope in the ward itself. All the findings were noted on a data sheet, and were analyzed. Results: A total of 24 patients of PIH were examined. Majority were urban (75%) and remaining are from rural area (25%). The majority of patients are from 24-28 years age group followed by below 20 years age group. The gestation period ranged from 20 weeks to 38 weeks; 16 (66.6%) were primi gravida. Nineteen (79.1%) patients had mild preeclampsia, 03 (12.5%) had severe preeclampsia and 2 (8.33%) had eclampsia. Retinal changes (hypertensive retinopathy) were not seen in any of these patients Haemorrhages or exudates or retinal detachment were not seen in any patient. There was no association of retinal changes and Rasa Sevan a found in present pilot study. Conclusion: Retinal changes were not seen in any of the patients with PIH in present study sample and there was not found to be associated with excess intake of specific Rasa and severity of the disease. Fundus examination is necessary in assessment of the PIH patient.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44506538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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