Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3695
Lily Meher, Kshirod Kumar Ratha, Arun Kumar Das
Background
This study aimed to investigate the preparation process of Rasaparpati, an Ayurvedic medicine containing Mercury that is commonly used to treat various ailments. The dangers of using Mercury as a therapeutic agent are acknowledged, and Ayurveda emphasizes purifying heavy metals before human use. The present study assessed the acute toxicity of Rasaparpati in albino rats to ensure its safe consumption.
Methodology
Following ethical guidelines and O.E.C.D. (423) protocol, Rasaparpati was prepared traditionally, and an acute toxicity study was conducted. Two groups of female Wistar rats were administered 300mg/kg and 2000mg/kg of Rasaparpati, and their behavioral changes, signs of toxicity, and mortality were closely monitored. Hematological, biochemical, and histopathological parameters were also examined for any changes. The data obtained were analyzed and evaluated using an unpaired t-test, with p < 0.05 considered significant.
Results
No deaths were observed following the administration of Rasaparpati in an acute toxicity study. There were no hematological or biochemical toxicity indications, even at ten time the therapeutic dose. However, the histopathological analysis revealed mild changes likely to heal and repair. These non-specific and reversible changes in rat cells suggest similar outcomes in human cells.
Conclusions
The acute toxicity study of Rasaparpati suggests its safety for animal use, indicating potential safety for human consumption. No adverse effects or mortality were observed, even at a dosage ten times higher than the therapeutic dose. However, more extensive research with larger sample sizes and control groups is recommended.
{"title":"Evaluation of acute toxicity of Rasaparpati - An Ayurvedic mercurial compound in Albino rats","authors":"Lily Meher, Kshirod Kumar Ratha, Arun Kumar Das","doi":"10.47552/ijam.v14i3.3695","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3695","url":null,"abstract":"Background
 This study aimed to investigate the preparation process of Rasaparpati, an Ayurvedic medicine containing Mercury that is commonly used to treat various ailments. The dangers of using Mercury as a therapeutic agent are acknowledged, and Ayurveda emphasizes purifying heavy metals before human use. The present study assessed the acute toxicity of Rasaparpati in albino rats to ensure its safe consumption.
 Methodology
 Following ethical guidelines and O.E.C.D. (423) protocol, Rasaparpati was prepared traditionally, and an acute toxicity study was conducted. Two groups of female Wistar rats were administered 300mg/kg and 2000mg/kg of Rasaparpati, and their behavioral changes, signs of toxicity, and mortality were closely monitored. Hematological, biochemical, and histopathological parameters were also examined for any changes. The data obtained were analyzed and evaluated using an unpaired t-test, with p < 0.05 considered significant.
 Results
 No deaths were observed following the administration of Rasaparpati in an acute toxicity study. There were no hematological or biochemical toxicity indications, even at ten time the therapeutic dose. However, the histopathological analysis revealed mild changes likely to heal and repair. These non-specific and reversible changes in rat cells suggest similar outcomes in human cells.
 Conclusions
 The acute toxicity study of Rasaparpati suggests its safety for animal use, indicating potential safety for human consumption. No adverse effects or mortality were observed, even at a dosage ten times higher than the therapeutic dose. However, more extensive research with larger sample sizes and control groups is recommended.
","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3710
Mitali Y Kubade, Priya Shetti, Sachin Gudasi
Background: A new Ultra performance liquid chromatographic analytical method was developed and validated for estimation of Quercetin in bulk powder. The reverse phase chromatographic elution using UPLC was carried out in gradient mode on C-18 column (Phenomenex Luna 5 µm, 150 mm X 4.6 mm) as stationary phase utilizing a mobile phase composed of Acetonitrile: 0.1 % formic acid buffer (50:50 v/v) with a flow rate of 1 ml/min and injection volume of 10µl. The analysis was performed at temperature of 400C and detection of eluent was carried out using photo diode array at 371 nm. The newly developed Ultra performance liquid chromatography method was validated in terms of linearity and range, system suitability, specificity, precision, sensitivity, robustness, ruggedness and accuracy as per ICH guidelines. Results: The retention time of quercetin was found to be at 3.9 min with total run time of analysis is 7 minutes. The linearity was observed between the concentration ranges from 0.5 to 16µg/ml with correlation coefficient 0.999. The precision assays values were found to be less than 2% for both the drugs. The Limit of Detection and Limit of Quantification were 0.47µg/ml and 1.44µg/ml for Quercetin. The mean percentage recovery values were found to be within the range of 90-110 %. Conclusion: The proposed method was found to be simple, specific, precise, sensitive, robust, rugged and accurate and can be used for routine quality control analysis of Quercetin.
背景:建立了一种新的超高效液相色谱法测定散装粉末中槲皮素的含量。以C-18色谱柱(Phenomenex Luna 5µm, 150 mm X 4.6 mm)为固定相，流动相为乙腈:0.1%甲酸缓冲液(50:50 v/v)，流速为1 ml/min，进样量为10µl，采用UPLC梯度模式进行反相色谱洗脱。分析温度为400℃，洗脱液检测采用光电二极管阵列，波长为371 nm。根据ICH指南，新开发的超高效液相色谱方法在线性和范围、系统适用性、特异性、精密度、灵敏度、稳健性、耐用性和准确性方面进行了验证。结果:槲皮素的保留时间为3.9 min，分析总运行时间为7 min。浓度在0.5 ~ 16µg/ml范围内呈线性关系，相关系数为0.999。两种药物的精密度测定值均小于2%。槲皮素的检出限和定量限分别为0.47µg/ml和1.44µg/ml。平均回收率在90 ~ 110%之间。结论:该方法简便、专属性好、精密度高、灵敏度高、鲁棒性好、坚固耐用、准确度高，可用于槲皮素的常规质量控制分析。
{"title":"New validated Ultra High Performance Liquid Chromatographic method for Estimation of Quercetin","authors":"Mitali Y Kubade, Priya Shetti, Sachin Gudasi","doi":"10.47552/ijam.v14i3.3710","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3710","url":null,"abstract":"Background: A new Ultra performance liquid chromatographic analytical method was developed and validated for estimation of Quercetin in bulk powder. The reverse phase chromatographic elution using UPLC was carried out in gradient mode on C-18 column (Phenomenex Luna 5 µm, 150 mm X 4.6 mm) as stationary phase utilizing a mobile phase composed of Acetonitrile: 0.1 % formic acid buffer (50:50 v/v) with a flow rate of 1 ml/min and injection volume of 10µl. The analysis was performed at temperature of 400C and detection of eluent was carried out using photo diode array at 371 nm. The newly developed Ultra performance liquid chromatography method was validated in terms of linearity and range, system suitability, specificity, precision, sensitivity, robustness, ruggedness and accuracy as per ICH guidelines. Results: The retention time of quercetin was found to be at 3.9 min with total run time of analysis is 7 minutes. The linearity was observed between the concentration ranges from 0.5 to 16µg/ml with correlation coefficient 0.999. The precision assays values were found to be less than 2% for both the drugs. The Limit of Detection and Limit of Quantification were 0.47µg/ml and 1.44µg/ml for Quercetin. The mean percentage recovery values were found to be within the range of 90-110 %. Conclusion: The proposed method was found to be simple, specific, precise, sensitive, robust, rugged and accurate and can be used for routine quality control analysis of Quercetin.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3661
Akhil Babu T, Rupali R Bawa, Nitin Chandurkar, Pavan R Gulhane
Introduction: The anthropometry techniques used today share similarities with the method described in Ayurveda by the acharyas. Ayurvedic science adopts a more personalized approach to measurement, taking into account individual variations in the body proportions for a greater precision in assessing each body part. In contrast to the modern approach, which relies on a generalized view, ayurvedic science offers significant advantages. Method: Survey conducted among 400 individuals to determine the correlation between swa anguli pramana (measurement of the width of the proximal phalanx of the middle finger in the palmar aspect) and aayama (height). Result: The study found that there was a change in the average swa anguli pramana values, which caused a noteworthy difference in the aayama of the individuals. The study clearly indicates that, swa anguli pramana is positively associated with height of individual. Discussion: However, the study does not invalidate the swa anguli pramana measurement technique or elevate the contemporary day standard metric system above it. The existing metric system has limitations, such as variations with changes in gender, race, and area, whereas swa anguli standards are individualistic and not impacted by these aspects. The study suggests that revalidation of the pramanas is required, but considering it as a standard system of measurement remains relevant.
{"title":"Importance of Swa Anguli Pramana in Health Assessment: Insights from Cross-Sectional Study on Aayama Relationship","authors":"Akhil Babu T, Rupali R Bawa, Nitin Chandurkar, Pavan R Gulhane","doi":"10.47552/ijam.v14i3.3661","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3661","url":null,"abstract":"Introduction: The anthropometry techniques used today share similarities with the method described in Ayurveda by the acharyas. Ayurvedic science adopts a more personalized approach to measurement, taking into account individual variations in the body proportions for a greater precision in assessing each body part. In contrast to the modern approach, which relies on a generalized view, ayurvedic science offers significant advantages. Method: Survey conducted among 400 individuals to determine the correlation between swa anguli pramana (measurement of the width of the proximal phalanx of the middle finger in the palmar aspect) and aayama (height). Result: The study found that there was a change in the average swa anguli pramana values, which caused a noteworthy difference in the aayama of the individuals. The study clearly indicates that, swa anguli pramana is positively associated with height of individual. Discussion: However, the study does not invalidate the swa anguli pramana measurement technique or elevate the contemporary day standard metric system above it. The existing metric system has limitations, such as variations with changes in gender, race, and area, whereas swa anguli standards are individualistic and not impacted by these aspects. The study suggests that revalidation of the pramanas is required, but considering it as a standard system of measurement remains relevant.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the oldest holistic medicinal systems in the world is Ayurveda, which has explained comprehensive pathophysiology of different diseases along with its management. One of the most significant and typical respiratory conditions listed in Ayurveda is Vataja kasa. It is mainly characterized by shushka kasa (dry cough), swarabheda (hoarseness in voice), kshinabala (weakness), hritshoola (pain in the chest), parshwashoola (pain in flanks), udarashoola (pain in abdomen), shirashoola (headache), etc. Due to outside factors including population growth, contamination of the environment, industrialization, and urbanisation, it has a growing prevalence throughout time. It is one of the typical complaints and is also a symptom of many Pranvah strotasa (respiratory system) disorders. Classics of Ayurveda, has elaborately Kasa as a distinct disease with its diagnostic details and plan of management. Even though multiple options are there for its management, Maricha kshaudra yoga, prescribed by Sushruta Samhita was not yet tested. Therefore, an effort was made to research the effectiveness of Maricha kshaudra yoga, a trial medicine, in the treatment of Vataja Kasa. Data was collected on the first, seventh, and fourteenth days after the medicine was administered, and it was determined to have significant efficacy.
{"title":"Clinical Study of Maricha Kshaudra Yoga in the Management of Vataja kasa (dry cough)","authors":"Manojkumar Chaudhari, Yogita Chaudhari, Priyanka Dawane, Anand Madgundi, Devdatta Deshmukh","doi":"10.47552/ijam.v14i3.3511","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3511","url":null,"abstract":"One of the oldest holistic medicinal systems in the world is Ayurveda, which has explained comprehensive pathophysiology of different diseases along with its management. One of the most significant and typical respiratory conditions listed in Ayurveda is Vataja kasa. It is mainly characterized by shushka kasa (dry cough), swarabheda (hoarseness in voice), kshinabala (weakness), hritshoola (pain in the chest), parshwashoola (pain in flanks), udarashoola (pain in abdomen), shirashoola (headache), etc. Due to outside factors including population growth, contamination of the environment, industrialization, and urbanisation, it has a growing prevalence throughout time. It is one of the typical complaints and is also a symptom of many Pranvah strotasa (respiratory system) disorders. Classics of Ayurveda, has elaborately Kasa as a distinct disease with its diagnostic details and plan of management. Even though multiple options are there for its management, Maricha kshaudra yoga, prescribed by Sushruta Samhita was not yet tested. Therefore, an effort was made to research the effectiveness of Maricha kshaudra yoga, a trial medicine, in the treatment of Vataja Kasa. Data was collected on the first, seventh, and fourteenth days after the medicine was administered, and it was determined to have significant efficacy.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3765
Rajorshi Sen Gupta, Sandip Roy, Rajesh Bose, Palash Mandal
Medicinal herbs, plants and their products show revolutionized effect in modern therapeutic system. Industries used their activity as antioxidant, antitoxin, antimicrobial, immune booster and many others and use them accordingly as the prime agent to produce cosmetics, food, drug synthesis etc. Unani is one of the traditional therapeutic system which use medicinal herbs mostly for making their herbal medicines. There are several immunomodulatory herbs along with their phytochemicals are present to serve their best. Bioassay is the method of analysis to find out the potency or concentration of any substance when effect on living things. Sars Cov-2 virus and its fatal outbreak is a real threat to modern society. To perform in vitro procedure to screened out small molecule inhibitors of this malicious pseudo typed particle cell entry, Dr. Whittaker's group use this bioassay system like PubChem AID: 1479144, PubChem AID: 1479149, PubChem AID: 1479150 and PubChem AID: 1494158. This in silico study is to show the potency of the phytochemicals of traditional herbs of Unani, as if inhibitors by means of machine learning with the help of WEKA. The ADMET study and molecular docking with Mpro (6lu7 chain A) is also done to test the druggability and binding affinity of the qualified phytochemicals.
{"title":"A Druggability study to Probe immunomodulatory Unani plants as active Inhibitors of Pseudotyped Particle Cell Entry","authors":"Rajorshi Sen Gupta, Sandip Roy, Rajesh Bose, Palash Mandal","doi":"10.47552/ijam.v14i3.3765","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3765","url":null,"abstract":"Medicinal herbs, plants and their products show revolutionized effect in modern therapeutic system. Industries used their activity as antioxidant, antitoxin, antimicrobial, immune booster and many others and use them accordingly as the prime agent to produce cosmetics, food, drug synthesis etc. Unani is one of the traditional therapeutic system which use medicinal herbs mostly for making their herbal medicines. There are several immunomodulatory herbs along with their phytochemicals are present to serve their best. Bioassay is the method of analysis to find out the potency or concentration of any substance when effect on living things. Sars Cov-2 virus and its fatal outbreak is a real threat to modern society. To perform in vitro procedure to screened out small molecule inhibitors of this malicious pseudo typed particle cell entry, Dr. Whittaker's group use this bioassay system like PubChem AID: 1479144, PubChem AID: 1479149, PubChem AID: 1479150 and PubChem AID: 1494158. This in silico study is to show the potency of the phytochemicals of traditional herbs of Unani, as if inhibitors by means of machine learning with the help of WEKA. The ADMET study and molecular docking with Mpro (6lu7 chain A) is also done to test the druggability and binding affinity of the qualified phytochemicals.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3818
Anjali G, Sangeeta T, Parappagoudra M, Dash G
Spinal canal stenosis is a painful, degenerative condition, and is localized to facets, joints, and ligamentum flavum of the vertebra which is often referred to for surgical correction. The main cause of stenosis is herniated vertebral disc. If there is no compression, the spinal canal can be referred to as narrow, but not stenotic. Certain studies have defined lumbar spinal stenosis as the narrowing of the osteo-ligamentous vertebral canal or the intervertebral foramina, which causes compression of the thecal sac or the caudal nerve roots. The narrowing may impact the entire canal or just a portion of it, but it occurs at a single vertebral level. In this condition, it may, drastically affect the quality of life due to severe pain in doing daily routine activities. In contemporary science, there is no treatment except surgical intervention which is having a high chance of complication and the chances of recurrence. Surgery is necessary when there are clinically significant motor deficiencies or symptoms of cauda equina syndrome. Based on the manifestation of clinical signs and symptoms it can be correlated with Gridhrasi, according to Ayurveda. Gridhrasi can be treated successfully by the intervention of Panchakarma procedures along with Shamana Chikitsa. Here is a case study of a patient suffering from low back pain radiating to bilateral lower limbs, stiffness, numbness, burning sensation in the bilateral sole region, and unable to walk without support, who was previously diagnosed as a case of Spinal Canal Stenosis. He was treated with a Panchakarma procedure, Shamana Chikitsa along with Physiotherapy Exercises. The patient showed marked improvement and could do daily routine activities properly.
{"title":"Role of Panchakarma in the Management of Spinal Canal Stenosis - A Case Study","authors":"Anjali G, Sangeeta T, Parappagoudra M, Dash G","doi":"10.47552/ijam.v14i3.3818","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3818","url":null,"abstract":"Spinal canal stenosis is a painful, degenerative condition, and is localized to facets, joints, and ligamentum flavum of the vertebra which is often referred to for surgical correction. The main cause of stenosis is herniated vertebral disc. If there is no compression, the spinal canal can be referred to as narrow, but not stenotic. Certain studies have defined lumbar spinal stenosis as the narrowing of the osteo-ligamentous vertebral canal or the intervertebral foramina, which causes compression of the thecal sac or the caudal nerve roots. The narrowing may impact the entire canal or just a portion of it, but it occurs at a single vertebral level. In this condition, it may, drastically affect the quality of life due to severe pain in doing daily routine activities. In contemporary science, there is no treatment except surgical intervention which is having a high chance of complication and the chances of recurrence. Surgery is necessary when there are clinically significant motor deficiencies or symptoms of cauda equina syndrome. Based on the manifestation of clinical signs and symptoms it can be correlated with Gridhrasi, according to Ayurveda. Gridhrasi can be treated successfully by the intervention of Panchakarma procedures along with Shamana Chikitsa. Here is a case study of a patient suffering from low back pain radiating to bilateral lower limbs, stiffness, numbness, burning sensation in the bilateral sole region, and unable to walk without support, who was previously diagnosed as a case of Spinal Canal Stenosis. He was treated with a Panchakarma procedure, Shamana Chikitsa along with Physiotherapy Exercises. The patient showed marked improvement and could do daily routine activities properly.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3896
Rajkumar Chinthala, Kamble S B, Bhagavathi NNL, Baghel A S
Background: Subgrouping of diseased population, based on Deha-Prakriti (DP), phenotypic classification of Ayurveda will explore the variation in the disease severity, which further aid in the management of the disease more precisely and selectively. But there is a paucity in the data generation. Amavata (~Rheumatoid Arthritis) is one of such diseases, resulting from the conglomeration of Ama and aggravated Vata gets lodged in the joints. Aim & Objective: To evaluate variations in the severity of symptoms, duration of morning stiffness, DAS28 (Disease Activity Score in 28 Joints), and Disability Index (DI) among different Vata predominant Deha-Prakriti (DP) individuals of Amavata (~Rheumatoid Arthritis). Materials & Methodology: The study was conducted among 155 clinically diagnosed patients of Amavata, who were screened for DP assessment through the CCRAS-PAS scale. Those who were found to have Vata predominant DP were sub-grouped into Single Vataja (V), Vata-Pittaja (VP), and Vata-Kaphaja (VK) DP, based on the proportion of the doshas in the output of scale. Demographic profile, the severity of the symptoms, duration of the morning stiffness, DAS28, and DI were assessed and calculated using SPSS software version 20.0, p≤0.05 was considered statistically significant. Results: Kruskal-Walli’s test revealed that Single Vata predominant DP patients were found to have severe Sandhi-shula (Joint pain) (p<0.0001), Shunatanga (Numbness of the joint) (p-value at 0.0069), Nidra-Viparyaya (Irregular sleep patterns) (p-value at 0.0012) than VP and VK DP individuals. Sandhi-Shotha (Joint swelling) (p-value at 0.0299), Angamarda (generalized body pains) (p-value at 0.0130), Alasya (laziness) (p<0.0001), Gaurava (Heaviness) (p<0.0001), and Apaka (delayed digestion) (p-value at 0.0254) were found severe in VK DP, whereas Trishna (Thirsty) (p<0.0001), Nidraviparyaya (p-value at 0.0012) were more severe in VP DP individuals. One-way ANOVA revealed that the duration of morning stiffness (2.03±0.2 hours, p-value at 0.446), DAS28 (6.85±0.175, p-value at 0.0035), and DI (1.87±0.54, p-value at 0.0003) were found significantly high in single Vataja than VP and VK Deha-Prakriti. Conclusion: The disease severity in terms of duration of morning stiffness, DAS28, and DI were found more severe in Single Vataja DP. The severity of the signs and symptoms also varied according to DP.
{"title":"Variations in the severity of symptoms, DAS28, and Disability Index among different Vata predominant Deha-Prakriti individuals of Amavata (~Rheumatoid Arthritis) - An Analytical Observational Study","authors":"Rajkumar Chinthala, Kamble S B, Bhagavathi NNL, Baghel A S","doi":"10.47552/ijam.v14i3.3896","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3896","url":null,"abstract":"Background: Subgrouping of diseased population, based on Deha-Prakriti (DP), phenotypic classification of Ayurveda will explore the variation in the disease severity, which further aid in the management of the disease more precisely and selectively. But there is a paucity in the data generation. Amavata (~Rheumatoid Arthritis) is one of such diseases, resulting from the conglomeration of Ama and aggravated Vata gets lodged in the joints. Aim & Objective: To evaluate variations in the severity of symptoms, duration of morning stiffness, DAS28 (Disease Activity Score in 28 Joints), and Disability Index (DI) among different Vata predominant Deha-Prakriti (DP) individuals of Amavata (~Rheumatoid Arthritis). Materials & Methodology: The study was conducted among 155 clinically diagnosed patients of Amavata, who were screened for DP assessment through the CCRAS-PAS scale. Those who were found to have Vata predominant DP were sub-grouped into Single Vataja (V), Vata-Pittaja (VP), and Vata-Kaphaja (VK) DP, based on the proportion of the doshas in the output of scale. Demographic profile, the severity of the symptoms, duration of the morning stiffness, DAS28, and DI were assessed and calculated using SPSS software version 20.0, p≤0.05 was considered statistically significant. Results: Kruskal-Walli’s test revealed that Single Vata predominant DP patients were found to have severe Sandhi-shula (Joint pain) (p<0.0001), Shunatanga (Numbness of the joint) (p-value at 0.0069), Nidra-Viparyaya (Irregular sleep patterns) (p-value at 0.0012) than VP and VK DP individuals. Sandhi-Shotha (Joint swelling) (p-value at 0.0299), Angamarda (generalized body pains) (p-value at 0.0130), Alasya (laziness) (p<0.0001), Gaurava (Heaviness) (p<0.0001), and Apaka (delayed digestion) (p-value at 0.0254) were found severe in VK DP, whereas Trishna (Thirsty) (p<0.0001), Nidraviparyaya (p-value at 0.0012) were more severe in VP DP individuals. One-way ANOVA revealed that the duration of morning stiffness (2.03±0.2 hours, p-value at 0.446), DAS28 (6.85±0.175, p-value at 0.0035), and DI (1.87±0.54, p-value at 0.0003) were found significantly high in single Vataja than VP and VK Deha-Prakriti. Conclusion: The disease severity in terms of duration of morning stiffness, DAS28, and DI were found more severe in Single Vataja DP. The severity of the signs and symptoms also varied according to DP.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background- Diabetes mellitus (DM) in India has a higher prevalence (4.3%) than in the west (1-2%) and its complication rate is also high. Diabetic neuropathy symptoms include pain, numbness, reduced sensation of touch or oversensitivity, uncomfortable tingling and burning, skin ulcer and reduced reflexes. Diabetic neuropathies are seen in approximately 50% of individuals with long standing type 1 and type 2 DM and it often goes undiagnosed. This article presents a case study of patient with signs and symptoms of neuropathy who came with the complaint of lower back pain, bilateral lower limb pain, pricking sensation and burning sensation. Diabetic Neuropathy Examination score (DNE) along with other neuropathy screening parameters was more than 60% indicating functional loss. The Nerve conduction study also revealed demyelinating polyneuropathy.
Observations and Results: The patient was treated with ayurvedic oral medication, Abhyanga (~application of medicated oils), swedana (~fomentation), and basti (~medicated enema). After ayurvedic treatment the patient showed good remission in pain, burning sensation and DNE along with all neuropathy screening were less than 20%. Patient got marked relief in all the symptoms.
{"title":"Ayurveda Management in Diabetic Neuropathy vis-à-vis Prameha Upadrava–A Case Study","authors":"Shweta Kodre, Jibi Varghese, Khan Aqsa Zarin, Snehal Pansare, Mohini Niware, Shreya Bhatia, Manna Mathew","doi":"10.47552/ijam.v14i3.3696","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3696","url":null,"abstract":"Background- Diabetes mellitus (DM) in India has a higher prevalence (4.3%) than in the west (1-2%) and its complication rate is also high. Diabetic neuropathy symptoms include pain, numbness, reduced sensation of touch or oversensitivity, uncomfortable tingling and burning, skin ulcer and reduced reflexes. Diabetic neuropathies are seen in approximately 50% of individuals with long standing type 1 and type 2 DM and it often goes undiagnosed. This article presents a case study of patient with signs and symptoms of neuropathy who came with the complaint of lower back pain, bilateral lower limb pain, pricking sensation and burning sensation. Diabetic Neuropathy Examination score (DNE) along with other neuropathy screening parameters was more than 60% indicating functional loss. The Nerve conduction study also revealed demyelinating polyneuropathy.
 Observations and Results: The patient was treated with ayurvedic oral medication, Abhyanga (~application of medicated oils), swedana (~fomentation), and basti (~medicated enema). After ayurvedic treatment the patient showed good remission in pain, burning sensation and DNE along with all neuropathy screening were less than 20%. Patient got marked relief in all the symptoms.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3830
Krishika M, Kashavva V Hiremath
The existence of life on Earth is sustained by the act of reproduction. The ultimate blessing for a couple in their lifetime is to give birth to a healthy progeny, which is only possible by the union of healthy beeja in the favorable conditions of Ritu, kshetra and ambhu. Female reproductive health plays a key role in all these four factors. Good reproductive health ensures a female to have a satisfactory and safe sexual life both physically and mentally. Rasayana prayoga during the course of dhatu utpatti in balya and madhyamavastha helps to attain the rasadi dhatu at its supreme quality. Acharya Sharangadhara quotes that the development of certain bodily characteristics attained in its pinnacle in every decade of life, starts to decline gradually after that certain period of years naturally. Rasayana therapy administered in each reproductive stage of female life may improve her reproductive health qualitatively which intern helps them to prevent various common reproductive aliments from balyatara avastha (pre-menarche) to Jara (complications after menopause). In this article, an attempt is made to collect and analyze the relevant facts from Samhitas, contemporary textbooks and e-resources and tried to conceptualize the significance of administering decade-wise Rasayana in female for improving their reproductive health.
{"title":"Decade-Wise Rasayana prayoga in Female Reproductive Health - A Conceptual study","authors":"Krishika M, Kashavva V Hiremath","doi":"10.47552/ijam.v14i3.3830","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3830","url":null,"abstract":"The existence of life on Earth is sustained by the act of reproduction. The ultimate blessing for a couple in their lifetime is to give birth to a healthy progeny, which is only possible by the union of healthy beeja in the favorable conditions of Ritu, kshetra and ambhu. Female reproductive health plays a key role in all these four factors. Good reproductive health ensures a female to have a satisfactory and safe sexual life both physically and mentally. Rasayana prayoga during the course of dhatu utpatti in balya and madhyamavastha helps to attain the rasadi dhatu at its supreme quality. Acharya Sharangadhara quotes that the development of certain bodily characteristics attained in its pinnacle in every decade of life, starts to decline gradually after that certain period of years naturally. Rasayana therapy administered in each reproductive stage of female life may improve her reproductive health qualitatively which intern helps them to prevent various common reproductive aliments from balyatara avastha (pre-menarche) to Jara (complications after menopause). In this article, an attempt is made to collect and analyze the relevant facts from Samhitas, contemporary textbooks and e-resources and tried to conceptualize the significance of administering decade-wise Rasayana in female for improving their reproductive health.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3883
Vijay kumar Pathak
ABSTRACT
Background
Acute myeloid leukemia (AML) is malignancy of the stem cell precursors of the myeloid lineage occurs due to variations in genetics. Incidence rate of childhood AML in Asian population is 8.4 per million. There is no exact description of AML is Ayurveda, it can be considered into Raktapitta (~bleeding disorder) disease. Hemidesmus indicus (L.) R.Br. (~H. indicus) is described for treatment of Raktapitta. The main treatment for AML is chemotherapy, and patient are searching for Ayurvedic medicines. Hence attempt is made for evaluating activity of H. indicus in AML.
Objective
To establish link for therapeutic activity of H. indicus in AML using Network pharmacology and molecular docking study.
Materials and methods
Active compound from root of H. indicus was retrieved from phytochemical based IMPPAT database. ADME (absorption, distribution, metabolism and excretion) study of retrieved active compound done with SwissADME database, and ADME qualified active compound target were obtained with having probability >0.7 from SwissTargetPrediction database. Target of AML retrieved from GeneCard database having relevancy score ≥5.0. To take the common, target of active compound and AML targets from GeneCard are imported into the Venny2.1 database, and the resulting targets used for the analysis. Cytoscape3.9.1 software was used to construct the "drug-active components-target" network diagram from common targets. The PPI (protein-protein interaction) network between proteins was constructed by STRING and result exported to Cytoscape3.9.1 for network analysis to get subnetwork with key target of subnetwork and core targets of overall PPI. GO (gene ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of key target from subnetwork done with g-profiler database. Core targets were docked with their corresponding active compound to get docking score.
Results
Total of 66 active compound were obtained from H. indicus, On ADME screening 49 active compounds qualified. ADME qualified active compound screened for target and 149 target obtained, after removal of duplicates 81 target were remained. 806 targets of AML were screened from GeneCard database. 19 common targets were obtained between target of active compound and target of AML from GeneCard. These screened 19 targets imported in STRING database to construct PPI network, and obtained result imported into Cytoscape3.9.1 for network analysis, on analysis 1 sub networks with 11 key targets were obtained. Top five H. indicus core targets for AML obtained using “CytoHubba” plug-in. GO and KEGG enrichment analyses were performed on the above-mentioned 11 key targets from sub network, 44 MF (Molecular function), 166 BP (Biological process), 12 CC (Cellular component) and 55 pathways were obtained from the KEGG pathway analyses. Molecular docking results showed that the active component quercetin could spontaneously bind to
{"title":"Network pharmacology and Molecular docking-based activity of Hemidesmus indicus (L.) R.Br. in Acute myeloid leukemia : A Computational Study","authors":"Vijay kumar Pathak","doi":"10.47552/ijam.v14i3.3883","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3883","url":null,"abstract":"ABSTRACT 
 Background 
 Acute myeloid leukemia (AML) is malignancy of the stem cell precursors of the myeloid lineage occurs due to variations in genetics. Incidence rate of childhood AML in Asian population is 8.4 per million. There is no exact description of AML is Ayurveda, it can be considered into Raktapitta (~bleeding disorder) disease. Hemidesmus indicus (L.) R.Br. (~H. indicus) is described for treatment of Raktapitta. The main treatment for AML is chemotherapy, and patient are searching for Ayurvedic medicines. Hence attempt is made for evaluating activity of H. indicus in AML.
 Objective
 To establish link for therapeutic activity of H. indicus in AML using Network pharmacology and molecular docking study. 
 Materials and methods
 Active compound from root of H. indicus was retrieved from phytochemical based IMPPAT database. ADME (absorption, distribution, metabolism and excretion) study of retrieved active compound done with SwissADME database, and ADME qualified active compound target were obtained with having probability >0.7 from SwissTargetPrediction database. Target of AML retrieved from GeneCard database having relevancy score ≥5.0. To take the common, target of active compound and AML targets from GeneCard are imported into the Venny2.1 database, and the resulting targets used for the analysis. Cytoscape3.9.1 software was used to construct the \"drug-active components-target\" network diagram from common targets. The PPI (protein-protein interaction) network between proteins was constructed by STRING and result exported to Cytoscape3.9.1 for network analysis to get subnetwork with key target of subnetwork and core targets of overall PPI. GO (gene ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis of key target from subnetwork done with g-profiler database. Core targets were docked with their corresponding active compound to get docking score.
 Results
 Total of 66 active compound were obtained from H. indicus, On ADME screening 49 active compounds qualified. ADME qualified active compound screened for target and 149 target obtained, after removal of duplicates 81 target were remained. 806 targets of AML were screened from GeneCard database. 19 common targets were obtained between target of active compound and target of AML from GeneCard. These screened 19 targets imported in STRING database to construct PPI network, and obtained result imported into Cytoscape3.9.1 for network analysis, on analysis 1 sub networks with 11 key targets were obtained. Top five H. indicus core targets for AML obtained using “CytoHubba” plug-in. GO and KEGG enrichment analyses were performed on the above-mentioned 11 key targets from sub network, 44 MF (Molecular function), 166 BP (Biological process), 12 CC (Cellular component) and 55 pathways were obtained from the KEGG pathway analyses. Molecular docking results showed that the active component quercetin could spontaneously bind to ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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