Chronic Rhinosinusitis is defined as a group of disorders characterized by inflammation of the mucosa of the nose and paranasal sinuses lasting for more than 12 weeks. Acute exacerbation of Chronic Rhinosinusitis is defined as a sudden worsening of symptoms in a patient who has chronic sinusitis. According to the science of Ayurveda, Dushta Pratisyaya condition, is in proximity to chronic sinusitis. Asava (fermented formulation) is mentioned for Virechana Nasya (type of Errhine therapy). Nimbasava is a formulation of Asava Kalpana prepared with Guggulu Tikthaka Gritha Yoga explained in Vaatavyadhi Chikitsa. Sigrubeeja (seed of Moringa Oleifera) and Saindhava (rock salt) are explained among Shirovirechana Gana (a group of medicines that can be used for nasal administration). The study was conducted on 30 patients of chronic sinusitis who were randomly divided into two groups and were given treatment for 7 days and follow-up after for 3 months. Out of two groups, 15 patients were given Virechana Nasya with Nimbasava, Sigru Beeja, and Saindhava for 7 days. The other 15 patients were treated as a standard control group and given the modern conventional management with Amoxicillin Clavulanate 500 mg, Fluticasone nasal spray, and Otrivin nasal drops for 7 days. The statistical analysis of data was done with the Wilcoxon Signed Rank Test and Mann-Whitney U test. During this trial, it was observed that Nimbasava Nasya with Sigrubeeja is effective in acute exacerbation of Chronic Rhinosinusitis. Pain relieving action of this Nasya was statistically highly significant. It was also found that the effectiveness of Nasya is more in reducing the recurrence of acute exacerbations of Chronic Rhinosinusitis.
{"title":"Effectiveness of Nimbasava Nasya with Sigru Beeja in Acute Exacerbation of Chronic Rhino Sinusitis - A Comparative Clinical Trial","authors":"Neethu Kesavan, Thrijil Krishnan EM, Sreeja Sukesan","doi":"10.47552/ijam.v15i2.4680","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4680","url":null,"abstract":"Chronic Rhinosinusitis is defined as a group of disorders characterized by inflammation of the mucosa of the nose and paranasal sinuses lasting for more than 12 weeks. Acute exacerbation of Chronic Rhinosinusitis is defined as a sudden worsening of symptoms in a patient who has chronic sinusitis. According to the science of Ayurveda, Dushta Pratisyaya condition, is in proximity to chronic sinusitis. Asava (fermented formulation) is mentioned for Virechana Nasya (type of Errhine therapy). Nimbasava is a formulation of Asava Kalpana prepared with Guggulu Tikthaka Gritha Yoga explained in Vaatavyadhi Chikitsa. Sigrubeeja (seed of Moringa Oleifera) and Saindhava (rock salt) are explained among Shirovirechana Gana (a group of medicines that can be used for nasal administration). The study was conducted on 30 patients of chronic sinusitis who were randomly divided into two groups and were given treatment for 7 days and follow-up after for 3 months. Out of two groups, 15 patients were given Virechana Nasya with Nimbasava, Sigru Beeja, and Saindhava for 7 days. The other 15 patients were treated as a standard control group and given the modern conventional management with Amoxicillin Clavulanate 500 mg, Fluticasone nasal spray, and Otrivin nasal drops for 7 days. The statistical analysis of data was done with the Wilcoxon Signed Rank Test and Mann-Whitney U test. During this trial, it was observed that Nimbasava Nasya with Sigrubeeja is effective in acute exacerbation of Chronic Rhinosinusitis. Pain relieving action of this Nasya was statistically highly significant. It was also found that the effectiveness of Nasya is more in reducing the recurrence of acute exacerbations of Chronic Rhinosinusitis.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.3516
Sumedh Sanjay Joshi, M. Deogade, T. Nesari
Every woman goes through several physiological and psychological storms throughout her life. Giving birth to a baby is a most glorious moment if proper care is taken during the time of pregnancy. In Ayurveda, before conception postnatal care has been explained elaborately for good progeny. The negligence in conducting proper Garbhini Paricharya (~Ante-natal care/ideal diet and Lifestyle during pregnancy) may lead to a dangerous outcome like Garbhasrava (~Miscarriage) or Garbhapata (~Abortion). For preventing the episodes of Miscarriage/Abortion Masanumas kashayas (MK) have been explained by Sushruta and Vagbhata. Modern-day research lacks evidence of the use effectiveness of these Kashayas, even though the prevalence of abortion is increasing despite development in the medical sciences. There is the occurrence of spontaneous miscarriage in India has been reported to be around 10%. However, it is observed in 32 % of Indian women. Thus, here is an attempt to review the Masanumas kashayas explained in Sushruta in the interest of the Dravyas mentioned in it. This article will include a review of these drugs from the point of Ayurveda and modern pharmacology.
{"title":"Relevance and assessment of Dravya (herbs) used in Masanumasa Chikitsa for prevention of Garbhasrava - A Review","authors":"Sumedh Sanjay Joshi, M. Deogade, T. Nesari","doi":"10.47552/ijam.v15i2.3516","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.3516","url":null,"abstract":"Every woman goes through several physiological and psychological storms throughout her life. Giving birth to a baby is a most glorious moment if proper care is taken during the time of pregnancy. In Ayurveda, before conception postnatal care has been explained elaborately for good progeny. The negligence in conducting proper Garbhini Paricharya (~Ante-natal care/ideal diet and Lifestyle during pregnancy) may lead to a dangerous outcome like Garbhasrava (~Miscarriage) or Garbhapata (~Abortion). For preventing the episodes of Miscarriage/Abortion Masanumas kashayas (MK) have been explained by Sushruta and Vagbhata. Modern-day research lacks evidence of the use effectiveness of these Kashayas, even though the prevalence of abortion is increasing despite development in the medical sciences. There is the occurrence of spontaneous miscarriage in India has been reported to be around 10%. However, it is observed in 32 % of Indian women. Thus, here is an attempt to review the Masanumas kashayas explained in Sushruta in the interest of the Dravyas mentioned in it. This article will include a review of these drugs from the point of Ayurveda and modern pharmacology. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4456
Ibamedabha Japang, Renu Rathi, Jitesh Verma
Background: Children with high IQ and memory have lower rates of poverty and dependency. Jyotishmati and Yastimadhu are both Medhya dravya to enhance IQ and memory describe in numerous Ayurveda classical texts. Aim &objectives: To compare the efficacy of Jyotishmati with Yastimadhu on IQ and Memory in children with various Prakriti types. Material & Methods: Total 60 healthy participants are enrolled and randomly divided into 2 equal main groups and 6 subgroups (VataPitta, VataKapha, PittaVata, PittaKapha, KaphaVata, KaphaPitta). Group-J (Intervention group) given Jyotishmati granules and Group-Y (Control group) given Yastimadhu granules both the interventions were administered for 60 days and follow up for 60 days. Observations & Result: While comparing Group J and Group Y, it showed highly significant at follow up in kapha-pitta groups with p<0.001 in IQ and statistically significant with p<0.05 in memory. Discussion: Kapha Pitta Prakriti dominant groups showed significant results in follow-up, because Kapha Prakriti persons are bestowed with Gunas (qualities) like Chirgrahi(slow grasping), Dhritiman (good retaining power) and Smritiman (good memory). Pitta Prakriti persons are Medhavi(sharp grasping) and Nipunmati(good retention power), together with the action of Jyotishmati granules, showed significant dominance over other Prakriti Doshas. Conclusion: The prevalence of low IQ at pre-treatment in Group J was 3.32 % and Group Y was 6.7%. In memory, Group J was 16.7% and Group Y was 10% are on Average memory. Both the groups were 100% improve to Average IQ, and 100% improve to Good memory in Group J but 96.7% in Group Y at post-treatment and follow-up. Jyotishmati and Yastimadhu granules were significant in enhancing IQ and memory.
{"title":"Evaluation of comparative Efficacy of Jyotishmati and Yastimadhu granules in Enhancing IQ and Memory in Children having different Prakriti –A double blind Randomized Clinical Trial","authors":"Ibamedabha Japang, Renu Rathi, Jitesh Verma","doi":"10.47552/ijam.v15i2.4456","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4456","url":null,"abstract":"Background: Children with high IQ and memory have lower rates of poverty and dependency. Jyotishmati and Yastimadhu are both Medhya dravya to enhance IQ and memory describe in numerous Ayurveda classical texts. Aim &objectives: To compare the efficacy of Jyotishmati with Yastimadhu on IQ and Memory in children with various Prakriti types. Material & Methods: Total 60 healthy participants are enrolled and randomly divided into 2 equal main groups and 6 subgroups (VataPitta, VataKapha, PittaVata, PittaKapha, KaphaVata, KaphaPitta). Group-J (Intervention group) given Jyotishmati granules and Group-Y (Control group) given Yastimadhu granules both the interventions were administered for 60 days and follow up for 60 days. Observations & Result: While comparing Group J and Group Y, it showed highly significant at follow up in kapha-pitta groups with p<0.001 in IQ and statistically significant with p<0.05 in memory. Discussion: Kapha Pitta Prakriti dominant groups showed significant results in follow-up, because Kapha Prakriti persons are bestowed with Gunas (qualities) like Chirgrahi(slow grasping), Dhritiman (good retaining power) and Smritiman (good memory). Pitta Prakriti persons are Medhavi(sharp grasping) and Nipunmati(good retention power), together with the action of Jyotishmati granules, showed significant dominance over other Prakriti Doshas. Conclusion: The prevalence of low IQ at pre-treatment in Group J was 3.32 % and Group Y was 6.7%. In memory, Group J was 16.7% and Group Y was 10% are on Average memory. Both the groups were 100% improve to Average IQ, and 100% improve to Good memory in Group J but 96.7% in Group Y at post-treatment and follow-up. Jyotishmati and Yastimadhu granules were significant in enhancing IQ and memory.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4320
Nandhini Elangovan, Chakravarthi P, K. S
Background: In the case of alopecia, the scalp's hair may completely or partially lost. The 5--reductase enzyme has been inhibited as a recent prophylactic treatment. Diahydrotestosterone, a more potent metabolite of testosterone, is produced when the enzyme 5--reductase is inhibited. Literature: Kushtakudori ennai, Siddha poly herbal drug is used as a Alopecia medicine mentioned in the literature Prana rakshamirtha sindhu.This research aimed to test activity of 9 known compounds contained within the herbs of Kushtakudori ennai as anti-alopecia. Methodology: Utilizing molecular docking and the Auto doc program, functionality was determined on their interaction with the androgen receptor (PDB code 4K7a). The steps in the research process were: creating databases of androgen protein structures; creating and perfecting three-dimensional structures of compounds; utilizing Autodock 1.5.6 to dock molecules to the androgen receptor protein; and using the pkCSM tool to estimate ADME-Tox. Observation and Inference: Total of 9 bioactive lead compounds were retrieved from the ingredients present on the polyherbal siddha formulation. From the reported data of the herbs, the phytochemicals such as Oleic acid, Chebuloside, Friedelin, Maslinic acid, Piperine, Isovitexin, Astragalin, Salsoline and Alangicine. The compound’s like Astragalin, Chebuloside, Friedelin and Piperine reveals maximum of four to five interactions with the bioactive residues present on the target androgen receptor. Other components such as Isovitexin, Salsoline, Maslinic acid and Alangicine revels maximum of three viable interactions with the target in comparison with standard drug Finasteride. Conclusion: Based on the results of the computational analysis it was concluded that the bio-active compound’s like Astragalin, Chebuloside, Friedelin, Piperine, Isovitexin, Salsoline, Maslinic acid and Alangicine reveals prominent interaction with active site of the receptor thereby it may hinder the binding of native ligand and also limit the follicle shrinkage and subsequent hair fall process. Hence it was concluded that the aforementioned phytocompounds may exerts promising anti-alopecia activity.
{"title":"Molecular docking study of phytochemical compounds from Kustakudori ennai as a potential anti-alopecia treatment","authors":"Nandhini Elangovan, Chakravarthi P, K. S","doi":"10.47552/ijam.v15i2.4320","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4320","url":null,"abstract":"Background: \u0000In the case of alopecia, the scalp's hair may completely or partially lost. The 5--reductase enzyme has been inhibited as a recent prophylactic treatment. Diahydrotestosterone, a more potent metabolite of testosterone, is produced when the enzyme 5--reductase is inhibited. \u0000 Literature: \u0000Kushtakudori ennai, Siddha poly herbal drug is used as a Alopecia medicine mentioned in the literature Prana rakshamirtha sindhu.This research aimed to test activity of 9 known compounds contained within the herbs of Kushtakudori ennai as anti-alopecia. \u0000Methodology: \u0000Utilizing molecular docking and the Auto doc program, functionality was determined on their interaction with the androgen receptor (PDB code 4K7a). The steps in the research process were: creating databases of androgen protein structures; creating and perfecting three-dimensional structures of compounds; utilizing Autodock 1.5.6 to dock molecules to the androgen receptor protein; and using the pkCSM tool to estimate ADME-Tox. \u0000Observation and Inference: \u0000Total of 9 bioactive lead compounds were retrieved from the ingredients present on the polyherbal siddha formulation. From the reported data of the herbs, the phytochemicals such as \u0000Oleic acid, Chebuloside, Friedelin, Maslinic acid, Piperine, Isovitexin, Astragalin, Salsoline and Alangicine. The compound’s like Astragalin, Chebuloside, Friedelin and Piperine reveals maximum of four to five interactions with the bioactive residues present on the target androgen receptor. Other components such as Isovitexin, Salsoline, Maslinic acid and Alangicine revels maximum of three viable interactions with the target in comparison with standard drug Finasteride. \u0000Conclusion: \u0000Based on the results of the computational analysis it was concluded that the bio-active compound’s like Astragalin, Chebuloside, Friedelin, Piperine, Isovitexin, Salsoline, Maslinic acid and Alangicine reveals prominent interaction with active site of the receptor thereby it may hinder the binding of native ligand and also limit the follicle shrinkage and subsequent hair fall process. Hence it was concluded that the aforementioned phytocompounds may exerts promising anti-alopecia activity.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4587
I. Gaikwad, Sadhana Misar Wajpeyi
Amlapitta is a condition characterised by the predominance of Pitta and is associated with the Annavaha and Purishvaha srotas. It manifests as a result of imbalances in Mandagni (weakened digestive fire) and the presence of Ama (undigested or improperly metabolized substances). The prevalence rate of Amlapitta in India is 38.1%. Considering the similarities in etiopathogenesis, it can be correlated with Hyperacidity in Modern Science. Aim and Objectives: To evaluate the efficacy of Avipattikar churna versus Chitrakadi kwath in the management of Amlapitta (Hyperacidity). Methodology: An Interventional Study was conducted among 30 patients between the ages of 20 and 60 of either sex who had symptoms of Tikta Amlodgar (sour and bitter irructation), Hrit-kanthadaha (burning in heart and throat), Udarashool (epigastric pain) and Utklesha (nausea), and Aruchi (anorexia). Group A was given Aipattikar Churna; Group B was given Chitrakadi Kwath. Subjective Parameters were assessed in both groups on the 0th, 7th, and 15th days, and comparison was done by statistical analysis. Observation and Discussion: Both interventions proved effective, showcasing strengths in addressing distinct subjective parameters. Conclusion: Both drugs demonstrated high effectiveness in the study. Group A exhibited significant improvements across all subjective parameters, except Udarshoola (Abdominal pain). On the other hand, Group B displayed notable results in all subjective parameters, except for Utklesha and Aruchi. In conclusion, both groups were significant.
{"title":"Evaluation of efficacy of Avipattikar churna versus Chitrakadi kwath in the management of Amlapitta (Hyperacidity) - A pilot study","authors":"I. Gaikwad, Sadhana Misar Wajpeyi","doi":"10.47552/ijam.v15i2.4587","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4587","url":null,"abstract":"Amlapitta is a condition characterised by the predominance of Pitta and is associated with the Annavaha and Purishvaha srotas. It manifests as a result of imbalances in Mandagni (weakened digestive fire) and the presence of Ama (undigested or improperly metabolized substances). The prevalence rate of Amlapitta in India is 38.1%. Considering the similarities in etiopathogenesis, it can be correlated with Hyperacidity in Modern Science. Aim and Objectives: To evaluate the efficacy of Avipattikar churna versus Chitrakadi kwath in the management of Amlapitta (Hyperacidity). Methodology: An Interventional Study was conducted among 30 patients between the ages of 20 and 60 of either sex who had symptoms of Tikta Amlodgar (sour and bitter irructation), Hrit-kanthadaha (burning in heart and throat), Udarashool (epigastric pain) and Utklesha (nausea), and Aruchi (anorexia). Group A was given Aipattikar Churna; Group B was given Chitrakadi Kwath. Subjective Parameters were assessed in both groups on the 0th, 7th, and 15th days, and comparison was done by statistical analysis. Observation and Discussion: Both interventions proved effective, showcasing strengths in addressing distinct subjective parameters. Conclusion: Both drugs demonstrated high effectiveness in the study. Group A exhibited significant improvements across all subjective parameters, except Udarshoola (Abdominal pain). On the other hand, Group B displayed notable results in all subjective parameters, except for Utklesha and Aruchi. In conclusion, both groups were significant.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In Ayurved classics Kasa is describes as a disease entity rather than a symptom. Many Respiratory Tract disorders can be incorporated under the broad umbrella of Kasa. Vataja Kasa which is characterized by Shuska mukha and gala, Shuska Kasa with Shuska alpa kapha, Swarbheda, Parshva Shool, Shira shool, Urashool, Daurbalya. It can be correlated symptomatically with Dry cough having sign and symptoms as Dry Cough, Coughing with small quantity of expectorant, Shortness of breath, Weakness, Soreness and dryness of throat, Heartburn, Pain in flank region, Dryness of mouth, Hoarseness of voice. Though it is not life threatening it impacts daily routine, work capacity as well as growth and development of a child. Aim and Objectives: To assess the efficacy of Aparajit Avaleha in the management of Vataja Kasa in Children and to study the probable mode of action of Aparajit Avaleha in management of Vataja Kasa. Materials and Methodology: In this study, total 30 patients of Vataja Kasa were included between 6 years to 12 years. The included patients were treated with Aparajit Avaleha described in Chakradutta thrice a day for 14 days with lukewarm water. The assessment was done on the basis of subjective as well as objective parameters. Results: Aparajit Avaleha showed statistically significant improvement in the subjective parameters as well as on objective parameters as most of the drugs possess pharmacological activities as Anti-inflammatory, Anti- asthmatic, Antibacterial, Antispasmodic, Immuno-stimulator, Anti-allergic, Anti- histaminic and Anti-pyretic. Conclusion: Aparajit Avaleha is effective in the management of Vataja Kasa in children.
{"title":"Efficacy of Aparajit avaleha in Vataja Kasa in children","authors":"Anshul Baloda, Aboli Baliram Patil, Swapnil Raskar, Jibi Varghese","doi":"10.47552/ijam.v15i2.4495","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4495","url":null,"abstract":"Background: In Ayurved classics Kasa is describes as a disease entity rather than a symptom. Many Respiratory Tract disorders can be incorporated under the broad umbrella of Kasa. Vataja Kasa which is characterized by Shuska mukha and gala, Shuska Kasa with Shuska alpa kapha, Swarbheda, Parshva Shool, Shira shool, Urashool, Daurbalya. It can be correlated symptomatically with Dry cough having sign and symptoms as Dry Cough, Coughing with small quantity of expectorant, Shortness of breath, Weakness, Soreness and dryness of throat, Heartburn, Pain in flank region, Dryness of mouth, Hoarseness of voice. Though it is not life threatening it impacts daily routine, work capacity as well as growth and development of a child. Aim and Objectives: To assess the efficacy of Aparajit Avaleha in the management of Vataja Kasa in Children and to study the probable mode of action of Aparajit Avaleha in management of Vataja Kasa. Materials and Methodology: In this study, total 30 patients of Vataja Kasa were included between 6 years to 12 years. The included patients were treated with Aparajit Avaleha described in Chakradutta thrice a day for 14 days with lukewarm water. The assessment was done on the basis of subjective as well as objective parameters. Results: Aparajit Avaleha showed statistically significant improvement in the subjective parameters as well as on objective parameters as most of the drugs possess pharmacological activities as Anti-inflammatory, Anti- asthmatic, Antibacterial, Antispasmodic, Immuno-stimulator, Anti-allergic, Anti- histaminic and Anti-pyretic. Conclusion: Aparajit Avaleha is effective in the management of Vataja Kasa in children. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4598
Gaurav Phull, Rekha Phull, Abhilasha Bhardwaj
Brachial Plexus disorders are encountered by neurologists as a big challenge despite ever advancing medical system. A variety of disorders affect the brachial plexus. Plexopathies related to inflammation, trauma, tumors, and radiation therapy form bulk of clinical case. This paper focuses on a Brachial Plexitis, an inflammation of the brachial plexus, which was treated solely with Ayurveda without using allopathic drugs. There is no proven treatment in western medicine and is typically managed conservatively. This study aims to explore the potential benefits of Marma Therapy as a treatment modality, contribute to the existing body of knowledge regarding alternative treatment option and provide evidence-based recommendations for healthcare professionals. In this interventional study, a 39-year-old male patient with complaints of pain, stiffness and restricted movements in the left upper extremity for two months was effectively managed using Marma Therapy in accordance with the principles of Vatavyadhi. The Shakagata Marma (located on left upper limb) and Pristha Marma points, including Kshipra, Talahridya, Indrabasti, Kurpara, Aani, Ansa & Ansaphalaka Marmas were subjected to controlled stimulation for a continuous period of 15 days. Following this, the stimulation was carried out intermittently once a week for two months. The patient also received Matra Basti for seven days and massage cupping for four days. Observations showed substantive improvement in pain, stiffness, and range of motion. Marma Therapy proved to be a safe, time-efficient, and cost-effective treatment resulting in complete remission of almost all signs and symptoms. There were no fresh complaints on follow up. The assessment was based on objective and subjective criteria.
{"title":"Management of Brachial Plexitis through Marma Therapy: A Case Report","authors":"Gaurav Phull, Rekha Phull, Abhilasha Bhardwaj","doi":"10.47552/ijam.v15i2.4598","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4598","url":null,"abstract":"Brachial Plexus disorders are encountered by neurologists as a big challenge despite ever advancing medical system. A variety of disorders affect the brachial plexus. Plexopathies related to inflammation, trauma, tumors, and radiation therapy form bulk of clinical case. This paper focuses on a Brachial Plexitis, an inflammation of the brachial plexus, which was treated solely with Ayurveda without using allopathic drugs. There is no proven treatment in western medicine and is typically managed conservatively. This study aims to explore the potential benefits of Marma Therapy as a treatment modality, contribute to the existing body of knowledge regarding alternative treatment option and provide evidence-based recommendations for healthcare professionals. In this interventional study, a 39-year-old male patient with complaints of pain, stiffness and restricted movements in the left upper extremity for two months was effectively managed using Marma Therapy in accordance with the principles of Vatavyadhi. The Shakagata Marma (located on left upper limb) and Pristha Marma points, including Kshipra, Talahridya, Indrabasti, Kurpara, Aani, Ansa & Ansaphalaka Marmas were subjected to controlled stimulation for a continuous period of 15 days. Following this, the stimulation was carried out intermittently once a week for two months. The patient also received Matra Basti for seven days and massage cupping for four days. Observations showed substantive improvement in pain, stiffness, and range of motion. Marma Therapy proved to be a safe, time-efficient, and cost-effective treatment resulting in complete remission of almost all signs and symptoms. There were no fresh complaints on follow up. The assessment was based on objective and subjective criteria.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Tuberculosis is one of the most common diseases of the present era, which affects the quality of life of patients. The present study was conducted with the aim of investigating the quality of life of patients with pulmonary tuberculosis referred to health centers in Ahvaz city. Methods: The current research is a cross-sectional study that was conducted on 75 patients with tuberculosis who referred to the health centers of Ahvaz city in 2021 through a simple random sampling method of patients with tuberculosis. Data collection tools include: demographic variables checklist and sf-36 standard questionnaire (Survey short-form 36-item health) which was collected in person. After completing the sampling, the data were analyzed using SPSS version 21 statistical software and descriptive and inferential statistical tests using independent t-tests, analysis of variance and chi-square. Results: The lowest average score was related to limited physical activity followed by psychological problems and social functioning. Also, independent t-test results showed that the average scores of quality of life in men and women, pulmonary and non-pulmonary tuberculosis patients, and the patient's place of residence are statistically and significantly different. Conclusion: According to the results, tuberculosis and its treatment affect the social performance, psychological and emotional aspects of the patients' quality of life.
导言：肺结核是当代最常见的疾病之一，影响着患者的生活质量。本研究旨在调查阿瓦士市医疗中心转诊的肺结核患者的生活质量。研究方法本研究是一项横断面研究，通过对肺结核患者进行简单随机抽样的方法，对 2021 年转诊至阿瓦士市医疗中心的 75 名肺结核患者进行了调查。数据收集工具包括：人口统计学变量核对表和SF-36标准问卷（健康调查简表36项），均为当面收集。完成抽样后，使用 SPSS 21 版统计软件对数据进行分析，并使用独立 t 检验、方差分析和卡方进行描述性和推断性统计检验。结果平均得分最低的是体力活动受限，其次是心理问题和社会功能。此外，独立 t 检验结果显示，男性和女性、肺结核和非肺结核患者以及患者居住地的生活质量平均得分在统计学上存在显著差异。结论根据研究结果，肺结核及其治疗会影响患者生活质量的社会表现、心理和情感方面。
{"title":"Investigating the Quality of Life in Patients with Tuberculosis: A Study in Southwest Iran","authors":"Shiva Moradi, Negin Asadiyan, Kosar Piri, Maryam Roze Ahvazi, Parastoo Daemi Mojdehi, Mojtaba Sharifpour, Nazanin Damsaz Hafshejani, Saba Rajabi Pour, Malihe Rahime, Raziyeh Shamshiry, Pouriya Darabiyan, Shaghayegh Salehi, Ali Ahmadi, Zahra Karimi Dastenaei","doi":"10.47552/ijam.v15i2.4850","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4850","url":null,"abstract":"Introduction: Tuberculosis is one of the most common diseases of the present era, which affects the quality of life of patients. The present study was conducted with the aim of investigating the quality of life of patients with pulmonary tuberculosis referred to health centers in Ahvaz city. Methods: The current research is a cross-sectional study that was conducted on 75 patients with tuberculosis who referred to the health centers of Ahvaz city in 2021 through a simple random sampling method of patients with tuberculosis. Data collection tools include: demographic variables checklist and sf-36 standard questionnaire (Survey short-form 36-item health) which was collected in person. After completing the sampling, the data were analyzed using SPSS version 21 statistical software and descriptive and inferential statistical tests using independent t-tests, analysis of variance and chi-square. Results: The lowest average score was related to limited physical activity followed by psychological problems and social functioning. Also, independent t-test results showed that the average scores of quality of life in men and women, pulmonary and non-pulmonary tuberculosis patients, and the patient's place of residence are statistically and significantly different. Conclusion: According to the results, tuberculosis and its treatment affect the social performance, psychological and emotional aspects of the patients' quality of life.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Quercus Leucotrichophora A. Camus (QL) seeds are used in traditional medicine to treat various urinary and renal diseases. It is used as a diuretic, antioxidant, and nephroprotective agent. In the present study, we investigated the in vitro and in vivo antiurolithiatic activity of methanolic extract of Quercus Leucotrichophora A. Camus (MEQL) Seeds. Methods: An in vitro assay was used to determine whether MEQL prevents the formation of calcium oxalate (CaOx) or promotes CaOx dissolution. In in vivo studies, the effects of oral administration of Methanolic extract of test drug were studied on calcium oxalate urolithiasis in male Wistar rats. Male Wistar rats were divided into six groups of 6 animals each. Animals of Normal control received regular drinking water ad libitum throughout the study. whereas in other groups nephrolithiasis was induced by providing drinking water containing 0.75% ethylene glycol and 1% ammonium chloride for 7 days. Test groups were treated with 250 mg/kg, 375 mg/kg, and 500 mg/kg of the test drug and standard control with Cystone (750 mg/kg) for 21 days. Urine was examined for the presence of crystals on the 8th and 22nd days. On the 22nd day, 24 h urine, serum was collected and various biochemical parameters were estimated in urine, serum, and kidney homogenate along with histology of the kidney. Results: In the in vitro experiments, MEQL exhibited a concentration-dependent inhibitory activity on nucleation and aggregation. The urine volume increased significantly in all test groups. Test groups showed a significant reduction in the number of CaOx crystals in urine. Levels of urinary calcium, phosphorus, and sodium; Serum levels of calcium, phosphorus, creatinine, and urea decreased significantly in standard and test groups. Histopathology shows significant changes. From the above results, it can be concluded that the methanolic extract of Quercus leucotrichophora seeds has a significant inhibitory effect on calcium oxalate urolithiasis due to their diuretic and antioxidant activity. Conclusion: These results indicate that MEQL showed significant activity in urolithiasis which might be due to diuretic and antioxidant action.
{"title":"Protective potential of Quercus leucotrichophora A. Camus seeds in chemically induced urolithiasis in rats","authors":"Pooja Gayakvad, Vipulkumar Gajera, Tanvi Desai, Priyanka Chaudhari, Dhara Parekh, Divya Solanki","doi":"10.47552/ijam.v15i2.4364","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4364","url":null,"abstract":"Background: Quercus Leucotrichophora A. Camus (QL) seeds are used in traditional medicine to treat various urinary and renal diseases. It is used as a diuretic, antioxidant, and nephroprotective agent. In the present study, we investigated the in vitro and in vivo antiurolithiatic activity of methanolic extract of Quercus Leucotrichophora A. Camus (MEQL) Seeds. Methods: An in vitro assay was used to determine whether MEQL prevents the formation of calcium oxalate (CaOx) or promotes CaOx dissolution. In in vivo studies, the effects of oral administration of Methanolic extract of test drug were studied on calcium oxalate urolithiasis in male Wistar rats. Male Wistar rats were divided into six groups of 6 animals each. Animals of Normal control received regular drinking water ad libitum throughout the study. whereas in other groups nephrolithiasis was induced by providing drinking water containing 0.75% ethylene glycol and 1% ammonium chloride for 7 days. Test groups were treated with 250 mg/kg, 375 mg/kg, and 500 mg/kg of the test drug and standard control with Cystone (750 mg/kg) for 21 days. Urine was examined for the presence of crystals on the 8th and 22nd days. On the 22nd day, 24 h urine, serum was collected and various biochemical parameters were estimated in urine, serum, and kidney homogenate along with histology of the kidney. Results: In the in vitro experiments, MEQL exhibited a concentration-dependent inhibitory activity on nucleation and aggregation. The urine volume increased significantly in all test groups. Test groups showed a significant reduction in the number of CaOx crystals in urine. Levels of urinary calcium, phosphorus, and sodium; Serum levels of calcium, phosphorus, creatinine, and urea decreased significantly in standard and test groups. Histopathology shows significant changes. From the above results, it can be concluded that the methanolic extract of Quercus leucotrichophora seeds has a significant inhibitory effect on calcium oxalate urolithiasis due to their diuretic and antioxidant activity. Conclusion: These results indicate that MEQL showed significant activity in urolithiasis which might be due to diuretic and antioxidant action.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Dyslipidemia is the disorder of lipoprotein metabolism manifested by an elevation of the total cholesterol, the low-density lipoprotein (LDL) cholesterol, the triglyceride concentrations, and a decrease in the high-density lipoprotein (HDL) cholesterol concentration in the blood. Today’s unhealthy food habits and sedentary lifestyle are the main causative factors for Dyslipidemia. It is not defined in Ayurveda, it can be related to a number of conditions, including "Medoroga, Rasa Raktagata Snehavruddhi Shonitabhishyandana, and Dhamanipratichaya" based on similarities in etiology, pathogenesis, and manifestations. Aim: Comparative evaluation of Efficacy of Kulattha Gutika and Atorvastatin in the Management of Dyslipidemia (Medoroga). Material and Methods: Study comprises total 60 patients of Dyslipidemia randomly divided into two equal groups. Group A (Experimental group) was treated with 1gm Kulattha Gutika thrice a day before meals with warm water and Group B (Control group) was treated with 10 mg Atorvastatin at night before sleep with water for 45 days. Patients were assessed for Objective parameters like Lipid profile (S. TCH, TG, LDL, HDL, VLDL) and BMI was done on 0 and 45th day. Result: Statistically significant improvement was observed in objective parameters like TCH, HDL, LDL, VLDL, and TG in both groups. But in BMI Statistically significant improvement was observed in group A, treated with Kulattha Gutika. Conclusion: Kulattha Gutika is as efficacious as Atorvastatin in managing Dyslipidemia (Medoroga) and is an economical alternative without adverse effects.
{"title":"Comparative evaluation of efficacy of Kulattha Gutika with Atorvastatin in the management of Dyslipidemia (Medoroga) - RCT","authors":"Praveen Nandal, Sadhana Misar Wajpeyi, Pankaj Yadav, Khushhali Balpande","doi":"10.47552/ijam.v15i2.4444","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4444","url":null,"abstract":"Introduction: Dyslipidemia is the disorder of lipoprotein metabolism manifested by an elevation of the total cholesterol, the low-density lipoprotein (LDL) cholesterol, the triglyceride concentrations, and a decrease in the high-density lipoprotein (HDL) cholesterol concentration in the blood. Today’s unhealthy food habits and sedentary lifestyle are the main causative factors for Dyslipidemia. It is not defined in Ayurveda, it can be related to a number of conditions, including \"Medoroga, Rasa Raktagata Snehavruddhi Shonitabhishyandana, and Dhamanipratichaya\" based on similarities in etiology, pathogenesis, and manifestations. Aim: Comparative evaluation of Efficacy of Kulattha Gutika and Atorvastatin in the Management of Dyslipidemia (Medoroga). Material and Methods: Study comprises total 60 patients of Dyslipidemia randomly divided into two equal groups. Group A (Experimental group) was treated with 1gm Kulattha Gutika thrice a day before meals with warm water and Group B (Control group) was treated with 10 mg Atorvastatin at night before sleep with water for 45 days. Patients were assessed for Objective parameters like Lipid profile (S. TCH, TG, LDL, HDL, VLDL) and BMI was done on 0 and 45th day. Result: Statistically significant improvement was observed in objective parameters like TCH, HDL, LDL, VLDL, and TG in both groups. But in BMI Statistically significant improvement was observed in group A, treated with Kulattha Gutika. Conclusion: Kulattha Gutika is as efficacious as Atorvastatin in managing Dyslipidemia (Medoroga) and is an economical alternative without adverse effects. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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