Herpes zoster is a very painful disease. Generally, it is a unilateral and self-limiting condition. Inappropriate or delayed therapy might make the disease worse and increase the risk of complications such as post-herpetic neuralgia. Age-related immunosuppression and low immunity make people more susceptible to herpes infection and more likely to develop post-herpetic neuralgia (15%). According to Ayurveda, it correlates with visarpa. It is a raktapradoshaj vikara (disease caused by vitiated blood) and primarily a pitta-predominant disease manifesting twaka (skin) so visarpa is one of the major skin diseases. Here we present a case of a 66-year-old female patient with k/c/o HTN and hypothyroidism visited the OPD with symptoms of unilateral onset of blisters on the right side of the back region, the right axillary region, and the medial aspect of the right arm, within 48 hours; along with burning Pain, itching, and sleeplessness due to burning. According to Ayurveda, the patient was clinically diagnosed with pittaj visarpa. Considering pitta dosha and rakta dhatu dusti, raktmokshan was planned as the prime treatment. The patient showed improvement in burning pain after the first setting of raktamokshan. The numeric rating scale revealed that the patient experienced relief in the severity of burning pain (from 8 to 0) and itching (from 5 to 0). Other Ayurveda treatments like pittaghna chikitsa (pitta pacifying) and pradeha (local application) were used. Rapid blister formation stopped within three days of treatment, and after 28 days, all blisters crusted off and a normal skin complexion was achieved. Thus, Ayurvedic treatment was valuable and cost-effective for treating conditions like herpes. Ayurveda protects patient’s immune systems and reduces the chances of post herpetic neuralgia and reinfection.
{"title":"Management of Herpes zoster in Ayurveda through Bloodletting therapy along with other Ayurveda treatment: A case study","authors":"Dipa Ashok Jain, Vinay Vasudeo Welankar, Abhijeet Sarjerao Shirkande, Jayshree V Changade, Ankita Abhijeet Shirkande","doi":"10.47552/ijam.v14i2.3387","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3387","url":null,"abstract":"Herpes zoster is a very painful disease. Generally, it is a unilateral and self-limiting condition. Inappropriate or delayed therapy might make the disease worse and increase the risk of complications such as post-herpetic neuralgia. Age-related immunosuppression and low immunity make people more susceptible to herpes infection and more likely to develop post-herpetic neuralgia (15%). According to Ayurveda, it correlates with visarpa. It is a raktapradoshaj vikara (disease caused by vitiated blood) and primarily a pitta-predominant disease manifesting twaka (skin) so visarpa is one of the major skin diseases. Here we present a case of a 66-year-old female patient with k/c/o HTN and hypothyroidism visited the OPD with symptoms of unilateral onset of blisters on the right side of the back region, the right axillary region, and the medial aspect of the right arm, within 48 hours; along with burning Pain, itching, and sleeplessness due to burning. According to Ayurveda, the patient was clinically diagnosed with pittaj visarpa. Considering pitta dosha and rakta dhatu dusti, raktmokshan was planned as the prime treatment. The patient showed improvement in burning pain after the first setting of raktamokshan. The numeric rating scale revealed that the patient experienced relief in the severity of burning pain (from 8 to 0) and itching (from 5 to 0). Other Ayurveda treatments like pittaghna chikitsa (pitta pacifying) and pradeha (local application) were used. Rapid blister formation stopped within three days of treatment, and after 28 days, all blisters crusted off and a normal skin complexion was achieved. Thus, Ayurvedic treatment was valuable and cost-effective for treating conditions like herpes. Ayurveda protects patient’s immune systems and reduces the chances of post herpetic neuralgia and reinfection.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41553728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3637
Ashwini Tonape, Vrushali Neve, Jui Darbhe, Vrushali Bhalchim
Background:While several anti-diabetic medications have been found to lower blood glucose levels, there are numerous negative effects connected with the use of currently marketed anti-diabetic medications.However, there are medicinal plants with anti-diabetic effects with low or no side effects. Among the Cucurbitaceae family of plants, Momordica dioica is a dioecious climbing herb. It contains many phytoconstituents.One of it is a quaternary ammonium salt of benzyl-isoquinoline alkaloid called as berberine exhibiting a wide variety of pharmaceutical properties.In the current investigation, the activities of berberine for its anti-diabetic potential in the Momorica Dioica plant.The goal of the recent effort is to establish and validate an HPTLC method that is quick, accurate, exact, and specific for determining berberine from herbal extract of Momordica dioica. Methodology/Conclusions/significance: For a quick examination to determine the amount of berberine, a (HPTLC) process was created as well as validated.On HPTLC aluminium plate 60 F254,precoated with silica gel chromatographic separation was accomplished using the solvents: methanol ,ethyl acetate, toluene and formic acid (2:4:3:0.5). A wavelength of 348 nm was used for detection. Rf was found to be 0.44±5% for berberine. There was linearity for berberine in the 400ng/band concentration range.The LOD and LOQ was found to be0.0096ng/band and 0.0293ng/ band for Berberine.The average berberine recovery rate was (0.041).The method's precision, accuracy, linearity, robustness, and specificity were all authenticated in accordance with ICH guidelines. The discovered approach can be used to regularly analyse Berberine in herbal formulations for quality control.
{"title":"Development and Validation of Analytical Method for Estimation of Berberine in Herbal Extract of Momordica Dioica","authors":"Ashwini Tonape, Vrushali Neve, Jui Darbhe, Vrushali Bhalchim","doi":"10.47552/ijam.v14i2.3637","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3637","url":null,"abstract":"Background:While several anti-diabetic medications have been found to lower blood glucose levels, there are numerous negative effects connected with the use of currently marketed anti-diabetic medications.However, there are medicinal plants with anti-diabetic effects with low or no side effects. Among the Cucurbitaceae family of plants, Momordica dioica is a dioecious climbing herb. It contains many phytoconstituents.One of it is a quaternary ammonium salt of benzyl-isoquinoline alkaloid called as berberine exhibiting a wide variety of pharmaceutical properties.In the current investigation, the activities of berberine for its anti-diabetic potential in the Momorica Dioica plant.The goal of the recent effort is to establish and validate an HPTLC method that is quick, accurate, exact, and specific for determining berberine from herbal extract of Momordica dioica. Methodology/Conclusions/significance: For a quick examination to determine the amount of berberine, a (HPTLC) process was created as well as validated.On HPTLC aluminium plate 60 F254,precoated with silica gel chromatographic separation was accomplished using the solvents: methanol ,ethyl acetate, toluene and formic acid (2:4:3:0.5). A wavelength of 348 nm was used for detection. Rf was found to be 0.44±5% for berberine. There was linearity for berberine in the 400ng/band concentration range.The LOD and LOQ was found to be0.0096ng/band and 0.0293ng/ band for Berberine.The average berberine recovery rate was (0.041).The method's precision, accuracy, linearity, robustness, and specificity were all authenticated in accordance with ICH guidelines. The discovered approach can be used to regularly analyse Berberine in herbal formulations for quality control.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42244525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3346
Pranoti Ranit, Mrunal G. Meshram, Renu Rathi, Devyani Taori, Priyanka Paul Madhu, Amit Reche
Background: Aphthous ulcer is seen to be one of the most commonly occurring ailments found among patients that dentists may come across on a daily basis. Taking into consideration the agents that have been used for treatment of aphthous stomatitis, it would seem advisable to apply the agent that is the safest and has the least toxic properties that can bring about symptomatic relief and that can be applied topically. These days, there are few reliable natural remedies that are emerging as a therapy for aphthae. Herbal and polyherbal medicines will alleviate pain, induce healing, prevent infection, and lessen inflammation in aphthous ulcers without any adverse effects. Aim: To evaluate the efficacy of Jati Ghrita and 1% chlorhexidine gluconate and its comparison on aphthous stomatitis patients.Materials and methods: A randomized control trial is carried out in the Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Dattatray Ayurvedic Rasashala.The study population consisting of 30 patients with Aphthous stomatitis is divided randomly into two groups i.e.,Jati Ghrita and 1% Chlorhexidine gluconate, each group consisting of 15 patients.The intergroup comparison is done by independent sample t test. Results: Jati Ghrita is found to be effective in faster healing of aphthous stomatitis with reduction in pain. Jati is found to be more effective than 1% chlorhexidine gluconate. Conclusion: Jati has good medicinal properties and ghee accelerates wound healing so combination of this was found to be effective for treating aphthous ulcers. It is advised to use these natural treatments in place of conventional medicine method in the treatment of recurrent aphthous stomatitis due to the affordability, accessibility, and lack of potential side effects of these herbal treatments.
{"title":"A Randomised Control Trial comparing the efficacy of Jati Ghrita and 1% Chlorhexidine Gluconate on Aphthous Stomatitis","authors":"Pranoti Ranit, Mrunal G. Meshram, Renu Rathi, Devyani Taori, Priyanka Paul Madhu, Amit Reche","doi":"10.47552/ijam.v14i2.3346","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3346","url":null,"abstract":"Background: Aphthous ulcer is seen to be one of the most commonly occurring ailments found among patients that dentists may come across on a daily basis. Taking into consideration the agents that have been used for treatment of aphthous stomatitis, it would seem advisable to apply the agent that is the safest and has the least toxic properties that can bring about symptomatic relief and that can be applied topically. These days, there are few reliable natural remedies that are emerging as a therapy for aphthae. Herbal and polyherbal medicines will alleviate pain, induce healing, prevent infection, and lessen inflammation in aphthous ulcers without any adverse effects. Aim: To evaluate the efficacy of Jati Ghrita and 1% chlorhexidine gluconate and its comparison on aphthous stomatitis patients.Materials and methods: A randomized control trial is carried out in the Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Dattatray Ayurvedic Rasashala.The study population consisting of 30 patients with Aphthous stomatitis is divided randomly into two groups i.e.,Jati Ghrita and 1% Chlorhexidine gluconate, each group consisting of 15 patients.The intergroup comparison is done by independent sample t test. Results: Jati Ghrita is found to be effective in faster healing of aphthous stomatitis with reduction in pain. Jati is found to be more effective than 1% chlorhexidine gluconate. Conclusion: Jati has good medicinal properties and ghee accelerates wound healing so combination of this was found to be effective for treating aphthous ulcers. It is advised to use these natural treatments in place of conventional medicine method in the treatment of recurrent aphthous stomatitis due to the affordability, accessibility, and lack of potential side effects of these herbal treatments.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45954753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3548
Suraj Kumar, Das Ashokkumar Nathulal
Aim: The medicinal plant Merremia gangetica Linn., family - Convolvulaceae, traditionally being used by the local healers due to its multiple therapeutic indications. Present review aims to collect currently available data on ethno-medicinal information and research updates on M. gangetica. Material and Methods: Available books related to traditional folklore uses of M. gangetica were searched from ethno-medicinal plants and published research articles. Along with various researches, name of reporting tribe and their place using the plant, vernacular names, parts used along with the therapeutic uses with specific methods of administration, if any, through either external or internal usages were also noted. Results: Across the globe in 2 countries and 8 states of India, M. gangetica has been reported for its traditional folklore therapeutic uses and in the management of 32 diseases conditions, various parts of the plants like whole plant, leaf, root and seed alone or along with other drugs are used either through external applications or internal administration. Maximum indicated in the treatment of rheumatism, neuralgia, headache, cough, etc. were reported. Whole plant has maximum application in 14, followed by leaf in 8, root in 4 and seed in 1 diseases condition. Pharmacological studies such as anti-arthritis, hepatoprotective, nephroprotective activities, etc. were also reported. Conclusion: M. gangetica is a folklore ethnomedicinal plant being used as medicine in rheumatism, neuralgia, headache, cough, etc. and also to establish its ethnic claims, plant need scientific evaluation through pharmacological and clinical studies.
{"title":"A Review on ethnomedicinal claims of Merremia gangetica Linn.","authors":"Suraj Kumar, Das Ashokkumar Nathulal","doi":"10.47552/ijam.v14i2.3548","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3548","url":null,"abstract":"Aim: The medicinal plant Merremia gangetica Linn., family - Convolvulaceae, traditionally being used by the local healers due to its multiple therapeutic indications. Present review aims to collect currently available data on ethno-medicinal information and research updates on M. gangetica. Material and Methods: Available books related to traditional folklore uses of M. gangetica were searched from ethno-medicinal plants and published research articles. Along with various researches, name of reporting tribe and their place using the plant, vernacular names, parts used along with the therapeutic uses with specific methods of administration, if any, through either external or internal usages were also noted. Results: Across the globe in 2 countries and 8 states of India, M. gangetica has been reported for its traditional folklore therapeutic uses and in the management of 32 diseases conditions, various parts of the plants like whole plant, leaf, root and seed alone or along with other drugs are used either through external applications or internal administration. Maximum indicated in the treatment of rheumatism, neuralgia, headache, cough, etc. were reported. Whole plant has maximum application in 14, followed by leaf in 8, root in 4 and seed in 1 diseases condition. Pharmacological studies such as anti-arthritis, hepatoprotective, nephroprotective activities, etc. were also reported. Conclusion: M. gangetica is a folklore ethnomedicinal plant being used as medicine in rheumatism, neuralgia, headache, cough, etc. and also to establish its ethnic claims, plant need scientific evaluation through pharmacological and clinical studies.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42759602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3434
Sathgowda A Patil, Vishal S. Patil, A. P. Malgi, V. B. Hupparage, Shamanand P. Mallapur, Reenal R Naik
Traditionally, Cananga odorata Hook. F. & Thomson (Ylang-Ylang) is commonly used to treat various diseases and has been assessed for anti-cancer potency in experimental animal models. However, the affinity of its phytocompounds with multiple proteins involved in the pathogenesis of cancer has not been illuminated yet. The present study was framed to elucidate the molecular mechanisms of Cananga odorata for its anticancer activity via compound-gene set pathway enrichment analysis, network pharmacology, and docking studies. Initially, phytocompounds were retrieved from herbs databases and literature. Structural information of each compound was obtained from the PubChem database. Druggable characteristics and side effects were predicted using MolSoft and ADVERpred. ADMET profile was predicted using PreADMET online server. Possible target proteins of each compound were predicted by BindingDB (p≥0.7). Compounds modulating the target proteins associated with the cancer were separated based on the successful and approved targets available in the Therapeutic Target Database. STRING and KEGG pathway database was used to analyze the molecular pathways modulated by the protein targets. The interaction between compounds, proteins, and pathways was constructed by Cytoscape 3.6.1, and docking of compounds with protein target was performed using AutoDock 4.2. Among 26 compounds, 12 phytocompounds were identified to modulate 34 pathways associated with cancer. 4-hydroxy-5,6,7-trimethoxyflavanone and Reticuline showed the maximum interactions with proteins involved in cancer. All 12 compounds obeyed the rule of five and p-methoxybenzaldehyde scored the highest drug-likeness score. Micheline A and Anonaine showed the highest binding affinity with Ubiquitin-protein ligase E3 (MDM2). The current study provides the molecular documentation of phytocompounds from Cananga odorata in the regulation of multi-proteins and pathways associated with progression of cancer (mainly Gastric, Melanoma, Prostate, and Breast cancer), which can be further investigated via wet-lab protocols.
{"title":"Cananga odorata (Ylang-Ylang) modulate pathways involved in cancer: Gene set enrichment and network pharmacology approach","authors":"Sathgowda A Patil, Vishal S. Patil, A. P. Malgi, V. B. Hupparage, Shamanand P. Mallapur, Reenal R Naik","doi":"10.47552/ijam.v14i2.3434","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3434","url":null,"abstract":"Traditionally, Cananga odorata Hook. F. & Thomson (Ylang-Ylang) is commonly used to treat various diseases and has been assessed for anti-cancer potency in experimental animal models. However, the affinity of its phytocompounds with multiple proteins involved in the pathogenesis of cancer has not been illuminated yet. The present study was framed to elucidate the molecular mechanisms of Cananga odorata for its anticancer activity via compound-gene set pathway enrichment analysis, network pharmacology, and docking studies. Initially, phytocompounds were retrieved from herbs databases and literature. Structural information of each compound was obtained from the PubChem database. Druggable characteristics and side effects were predicted using MolSoft and ADVERpred. ADMET profile was predicted using PreADMET online server. Possible target proteins of each compound were predicted by BindingDB (p≥0.7). Compounds modulating the target proteins associated with the cancer were separated based on the successful and approved targets available in the Therapeutic Target Database. STRING and KEGG pathway database was used to analyze the molecular pathways modulated by the protein targets. The interaction between compounds, proteins, and pathways was constructed by Cytoscape 3.6.1, and docking of compounds with protein target was performed using AutoDock 4.2. Among 26 compounds, 12 phytocompounds were identified to modulate 34 pathways associated with cancer. 4-hydroxy-5,6,7-trimethoxyflavanone and Reticuline showed the maximum interactions with proteins involved in cancer. All 12 compounds obeyed the rule of five and p-methoxybenzaldehyde scored the highest drug-likeness score. Micheline A and Anonaine showed the highest binding affinity with Ubiquitin-protein ligase E3 (MDM2). The current study provides the molecular documentation of phytocompounds from Cananga odorata in the regulation of multi-proteins and pathways associated with progression of cancer (mainly Gastric, Melanoma, Prostate, and Breast cancer), which can be further investigated via wet-lab protocols.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47172993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3448
Sujata P. Dhoke, Murali Krishna C, Savita Gopod, A. K, Midhuna Mohan K, Nishanth K
Hair is one of the essential characteristic features which not only adds beauty to the person but also helps maintain normal physiological functions, especially by excreting sweat through the Lomakupa, which is considered one of the roots of Swedavaha Strotas. It also helps in thermoregulation, protection etc. It is Pitruja Bhava and is the Mala of Asthidhatu. Depending upon the Hair conditions, one can assess some of the underlying pathological status of the body. Aims & Objectives: Review the literature concerned with Prakruta and Vikruta Lakshnas of hairs in Ayurvedic classical texts for diagnosis and prognosis of the disease. Material and Methods: Material related to Hair has been collected from Charaka Samhita, Sushruta Samhita, Astanga Samgraha, and Ashtanga Hridaya along with respective commentaries available and data associated with a topic general at different journals and books. Observations: As Kesha is one of the factors which build up a person's personality, Ayurvedic classics state the advantages of hair maintenance. In the present era, changes in lifestyle, food habits, excess use of shampoos, and hair dyes, lack of oil massage to Hair, pollution, stress and strain etc., may be the cause of different types of hair problems like Khalitya (Alopecia totalis), Palitya (premature greying of Hair) etc. Therefore a proper understanding of Prakruta Lakshanas of Kesha will help in understanding the Vaikrutha Avastha which will thus ease the line of treatment. Results: Thus, Kesha and Loma play an essential role in diagnosing the Prakruta and Vaikrutha Lakshana and help in the prognosis of the disease.
{"title":"A review of Kesha as diagnostic and prognostic tool in Ayurveda","authors":"Sujata P. Dhoke, Murali Krishna C, Savita Gopod, A. K, Midhuna Mohan K, Nishanth K","doi":"10.47552/ijam.v14i2.3448","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3448","url":null,"abstract":"Hair is one of the essential characteristic features which not only adds beauty to the person but also helps maintain normal physiological functions, especially by excreting sweat through the Lomakupa, which is considered one of the roots of Swedavaha Strotas. It also helps in thermoregulation, protection etc. It is Pitruja Bhava and is the Mala of Asthidhatu. Depending upon the Hair conditions, one can assess some of the underlying pathological status of the body. Aims & Objectives: Review the literature concerned with Prakruta and Vikruta Lakshnas of hairs in Ayurvedic classical texts for diagnosis and prognosis of the disease. Material and Methods: Material related to Hair has been collected from Charaka Samhita, Sushruta Samhita, Astanga Samgraha, and Ashtanga Hridaya along with respective commentaries available and data associated with a topic general at different journals and books. Observations: As Kesha is one of the factors which build up a person's personality, Ayurvedic classics state the advantages of hair maintenance. In the present era, changes in lifestyle, food habits, excess use of shampoos, and hair dyes, lack of oil massage to Hair, pollution, stress and strain etc., may be the cause of different types of hair problems like Khalitya (Alopecia totalis), Palitya (premature greying of Hair) etc. Therefore a proper understanding of Prakruta Lakshanas of Kesha will help in understanding the Vaikrutha Avastha which will thus ease the line of treatment. Results: Thus, Kesha and Loma play an essential role in diagnosing the Prakruta and Vaikrutha Lakshana and help in the prognosis of the disease. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44430524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3644
Sridhanya Venkataramanan, Rajeshwari V Kamat
Gas chromatography with mass spectrometric detectors are used to separate different analytes present in a mixture and identify the same. It can also be used for quantification of the analytes. Sample preparation is essential for GC-MS analysis to obtain desired analytes. Aim of the study: The present study is pursued to profile the phytochemicals present in Arjunarishta, a medicated alcoholic preparation through Dichloromethane (DCM) and Ethyl acetate (EA). Materials and Methods: A sample obtained from a GMP-certified pharmacy was subjected to liquid-liquid extraction using DCM and EA, which was examined with GC-MS. Results: The analysis yielded 19 and 20 phytochemicals in DCM and EA respectively. Presumably, due to a small difference in the polarity of the solvents used, nine phytochemicals such as Ethyl gallate, Catechols etc., were found in both extracts. Conclusion: 30 unique phytochemicals were established in two different solvent extracts of the same sample.
{"title":"Gas Chromatography Mass Spectrometry (GC-MS) Profiling of Arjunarishta","authors":"Sridhanya Venkataramanan, Rajeshwari V Kamat","doi":"10.47552/ijam.v14i2.3644","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3644","url":null,"abstract":"Gas chromatography with mass spectrometric detectors are used to separate different analytes present in a mixture and identify the same. It can also be used for quantification of the analytes. Sample preparation is essential for GC-MS analysis to obtain desired analytes. Aim of the study: The present study is pursued to profile the phytochemicals present in Arjunarishta, a medicated alcoholic preparation through Dichloromethane (DCM) and Ethyl acetate (EA). Materials and Methods: A sample obtained from a GMP-certified pharmacy was subjected to liquid-liquid extraction using DCM and EA, which was examined with GC-MS. Results: The analysis yielded 19 and 20 phytochemicals in DCM and EA respectively. Presumably, due to a small difference in the polarity of the solvents used, nine phytochemicals such as Ethyl gallate, Catechols etc., were found in both extracts. Conclusion: 30 unique phytochemicals were established in two different solvent extracts of the same sample. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49222938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3597
Kashikar Prathamesh Pradeep, Babar Sanjay Chandrakant, K. Archana, Gupta Janesh
The discovery of De Quervain's Tenosynovitis was much acknowledged in classical books in terms of symptoms that could be associated to Vatarakta (Gout), but the disease's nomenclature was only identified in the later period of global modernization. This case study describes a young woman who was pre-diagnosed with De Quervain's condition and treated using the Vatarakta paradigm of treatment protocols, principally raktamokshana (Blood-letting). Raktamokshana with the advent of jalauka (leech) is taken into consideration in the study because Vata and Rakta (blood) are vitiated, which furthers the disease. Rakatamokshana is an excellent treatment option for De Quervain's Tenosynovitis due to its efficiency, simplicity of administration, and safe therapy regimen. With outstanding results for pain management and the restoration of the functioning of the wrist joint, this therapy modality can therefore be recommended for the condition. Need of study: To evaluate the new conceptual idea for treating De Quervain’s Tenosynovitis that is non-invasive and helps to restoring the normal function of corresponding hand and wrist movements. Methodology: Current case report presents a 34-year-old woman with a right-hand dominant job whose primary complaints were pain, morning stiffness, localized burning sensation and swelling at the radial styloid process on the right hand at the base of the thumb for the past two months, who was diagnosed as De Quervain’s Tenosynovitis and was treated with Raktamokshana with Jaluka with two sittings. Conclusion: After first sitting she had 80% relief from symptoms and was totally symptomless after second sitting of Raktamokshana, helping new therapeutic regimen to treat the disease.
De Quervain的Tenosynovitis的发现在古典书籍中被公认为与Vatarakta（痛风）有关的症状，但该疾病的命名法是在全球现代化的后期才确定的。本案例研究描述了一名年轻女性，她被预先诊断为De Quervain的病情，并使用Vatarakta治疗方案的范例进行治疗，主要是raktamokshana（放血）。研究中考虑了随着墨西哥水蛭（jalauka）的出现而出现的Raktamokshana，因为Vata和Rakta（血液）被破坏，从而加剧了疾病。Rakatamokshana是治疗De Quervain’s Tenosynovitis的绝佳选择，因为它具有效率高、给药简单和安全的治疗方案。由于在疼痛管理和腕关节功能恢复方面取得了突出的效果，因此可以推荐这种治疗方式来治疗这种情况。研究需要：评估治疗De Quervain氏Tenosynovitis的新概念，该概念是无创的，有助于恢复相应手和手腕运动的正常功能。方法：目前的病例报告介绍了一名34岁的女性，她主要从事右手主导性工作，在过去的两个月里，她的主要症状是疼痛、晨僵、局部烧灼感和右手拇指基部桡骨柄突肿胀，他被诊断为De Quervain的Tenosynovitis，并接受了Raktamokshana和Jaluka的两次治疗。结论：第一次坐后症状减轻80%，第二次坐后完全无症状，有助于新的治疗方案治疗该病。
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Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3642
Dhivya G, Bharathy K, Lakshmi Kantham T, M. R
Background: PCOS is characterized by ovulatory failure, hirsutism, obesity, glucose intolerance, resistance to insulin, dyslipidemia and infertility. Siddha system of medicine has a worthwhile therapeutic effect in treating PCOS. The bioactive compounds of Kalingathy Thailam mentioned in Siddha literature was selected for evaluating their ability to inhibit CYP- 17α-hydroxylase. Objective: The study is aimed to perform the In Silico computational screening of the formulation Kalingathy Thailam against the target enzyme CYP-17 α -hydroxylase in PCOS. Methods: Autodock program was used against the target enzyme CYP-17 α -hydroxylase for the phytocomponents such as Sinapic acid, Cucurbitacin B of Citrullus colocynthis (L. ) Schrader, Aromadendrene, Linolenic acid of Melia dubia Linn. , Onionin A, Protocatechuic acid of Allium cepa Linn. , Ascorbic acid, Limonene of Citrus limon (L. )Burm. f. , Ricinine of Ricinus communis Linn. Results: A total of 9 components were screened, out of these Protocatechuic acid, Ascorbic acid, Linolenic acid and Cucurbitacin B reveals maximum of 2 to 3 interactions accounting for 75-100% binding efficacy with the core active amino acid residues present on the target enzyme CYP- 17α-hydroxylase. Conclusion: Based on the results of the computational analysis it was concluded that the bio-active compounds present in the herbal ingredients possess significant binding against the target enzyme CYP-17α-hydroxylase by interacting with active amino acids. Hence these phytocomponents which inhibit the target enzyme may act as a potential therapeutic agent for management of PCOD.
{"title":"An Insilico Computational Screening of Siddha Formulation Kalingathy Thailam against Cyp- 17α-Hydroxylase in PCOS","authors":"Dhivya G, Bharathy K, Lakshmi Kantham T, M. R","doi":"10.47552/ijam.v14i2.3642","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3642","url":null,"abstract":"Background: PCOS is characterized by ovulatory failure, hirsutism, obesity, glucose intolerance, resistance to insulin, dyslipidemia and infertility. Siddha system of medicine has a worthwhile therapeutic effect in treating PCOS. The bioactive compounds of Kalingathy Thailam mentioned in Siddha literature was selected for evaluating their ability to inhibit CYP- 17α-hydroxylase. Objective: The study is aimed to perform the In Silico computational screening of the formulation Kalingathy Thailam against the target enzyme CYP-17 α -hydroxylase in PCOS. Methods: Autodock program was used against the target enzyme CYP-17 α -hydroxylase for the phytocomponents such as Sinapic acid, Cucurbitacin B of Citrullus colocynthis (L. ) Schrader, Aromadendrene, Linolenic acid of Melia dubia Linn. , Onionin A, Protocatechuic acid of Allium cepa Linn. , Ascorbic acid, Limonene of Citrus limon (L. )Burm. f. , Ricinine of Ricinus communis Linn. Results: A total of 9 components were screened, out of these Protocatechuic acid, Ascorbic acid, Linolenic acid and Cucurbitacin B reveals maximum of 2 to 3 interactions accounting for 75-100% binding efficacy with the core active amino acid residues present on the target enzyme CYP- 17α-hydroxylase. Conclusion: Based on the results of the computational analysis it was concluded that the bio-active compounds present in the herbal ingredients possess significant binding against the target enzyme CYP-17α-hydroxylase by interacting with active amino acids. Hence these phytocomponents which inhibit the target enzyme may act as a potential therapeutic agent for management of PCOD. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45220693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3638
Nikil Niva John Raja, Hema Nandhini Devi Veluchamy, Muthu Vignesh Sivanan
Inflammation of one or more of the paranasal sinuses is called sinusitis. Sinusitis is classified 4 types based on symptoms persist. Bacterial or fungal infections are common causes for Chronic sinusitis One of the eight Indian peoples are affected by chronic sinusitis. According to siddha literature sinusitis is correlated with the symptoms of Peenisam, which is also called mukkataippu. 08/03/2022 a 27- year male patient attend our Muthu Siddha Hospital Seranmahadevi with the complaints of cold, rhinitis, nasal congestion, sneezing at every morning, itching present in both nasal cavity, pain present in nearby both maxillary region since last one month. A patient had a previous history of Chronic sinusitis. Symptoms are significantly reduced were observed under the siddha medicines such as a combination of siddha Sastric chooranam (Thalisathi chooranam, Palagarai parpam, Pavala parpam, Muthucippi parpam), Vasanthakusamakaram tablet for internal and Chukku Thailam is used for external use in oil bath. No recurrence of any chronic sinusitis clinical features like sneezing, nasal congestion and pain was observed during the five months of follow-up of siddha intervention done. To conclude this case report showed siddha medicines are very effective in the treatment of chronic sinusitis.
{"title":"Management of Chronic sinusitis through Siddha Treatment - A Case Report","authors":"Nikil Niva John Raja, Hema Nandhini Devi Veluchamy, Muthu Vignesh Sivanan","doi":"10.47552/ijam.v14i2.3638","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3638","url":null,"abstract":"Inflammation of one or more of the paranasal sinuses is called sinusitis. Sinusitis is classified 4 types based on symptoms persist. Bacterial or fungal infections are common causes for Chronic sinusitis One of the eight Indian peoples are affected by chronic sinusitis. According to siddha literature sinusitis is correlated with the symptoms of Peenisam, which is also called mukkataippu. 08/03/2022 a 27- year male patient attend our Muthu Siddha Hospital Seranmahadevi with the complaints of cold, rhinitis, nasal congestion, sneezing at every morning, itching present in both nasal cavity, pain present in nearby both maxillary region since last one month. A patient had a previous history of Chronic sinusitis. Symptoms are significantly reduced were observed under the siddha medicines such as a combination of siddha Sastric chooranam (Thalisathi chooranam, Palagarai parpam, Pavala parpam, Muthucippi parpam), Vasanthakusamakaram tablet for internal and Chukku Thailam is used for external use in oil bath. No recurrence of any chronic sinusitis clinical features like sneezing, nasal congestion and pain was observed during the five months of follow-up of siddha intervention done. To conclude this case report showed siddha medicines are very effective in the treatment of chronic sinusitis. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41797330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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