Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4498
Atul Desai, K. Desai, Hemshree Desai, R. Desai, Chirag V Desai
Background: Sickle cell disease (SCD), a genetic disorder caused by a beta globin chain mutation, has been recognized as influencing public health worldwide. In India, numerous tribal and underdeveloped groups frequently suffer from this medical condition. The present study evaluates the effectiveness and safety of alternative medicines T-AYU-HM Premium among paediatric SCD patients. Methodology: A single-arm retrospective observational case series of 10 sickle cell disease paediatric population were conducted. The proposed study was conducted to clinically evaluate the safety and effectiveness of T-AYU-HM Premium Tablet (300mg) on paediatric individuals. The clinical and vital data of the patients were collected, evaluated, and reported using the SPSS software based on inclusion and exclusion criteria. Results: The study had a majority of male (80%) patients with a mean age of 3.20±1.23 years. The present study also identified consanguinity. It also observed a non-significant improvement in weight (12.04 ± 2.45) compared to the baseline (11.64 ± 2.46). There was also a non-significantly decrease in the pulse rate from baseline. In terms of hematological parameters, no significant change was observed from the baseline. However, there was a substantial decrease in pain-associated clinical parameters among the paediatric population. Conclusion: The present retrospective analysis shows that patients with SCD were significantly improved by the T-AYU-HM Premium treatment, proving both its efficacy and safety, particularly in pain management. However, the current analysis suggests a substantial body of evidence (prospective) to support using herbal-mineral formulations for sickle cell anaemia among paediatric patients.
{"title":"Role of T-AYU-HM Premium in Paediatric Patients with Sickle Cell Anaemia: A Retrospective Case Series","authors":"Atul Desai, K. Desai, Hemshree Desai, R. Desai, Chirag V Desai","doi":"10.47552/ijam.v15i2.4498","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4498","url":null,"abstract":"Background: Sickle cell disease (SCD), a genetic disorder caused by a beta globin chain mutation, has been recognized as influencing public health worldwide. In India, numerous tribal and underdeveloped groups frequently suffer from this medical condition. The present study evaluates the effectiveness and safety of alternative medicines T-AYU-HM Premium among paediatric SCD patients. Methodology: A single-arm retrospective observational case series of 10 sickle cell disease paediatric population were conducted. The proposed study was conducted to clinically evaluate the safety and effectiveness of T-AYU-HM Premium Tablet (300mg) on paediatric individuals. The clinical and vital data of the patients were collected, evaluated, and reported using the SPSS software based on inclusion and exclusion criteria. Results: The study had a majority of male (80%) patients with a mean age of 3.20±1.23 years. The present study also identified consanguinity. It also observed a non-significant improvement in weight (12.04 ± 2.45) compared to the baseline (11.64 ± 2.46). There was also a non-significantly decrease in the pulse rate from baseline. In terms of hematological parameters, no significant change was observed from the baseline. However, there was a substantial decrease in pain-associated clinical parameters among the paediatric population. Conclusion: The present retrospective analysis shows that patients with SCD were significantly improved by the T-AYU-HM Premium treatment, proving both its efficacy and safety, particularly in pain management. However, the current analysis suggests a substantial body of evidence (prospective) to support using herbal-mineral formulations for sickle cell anaemia among paediatric patients.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4398
Yogesh Yadav, Sheetal G. Asutkar
Pressure ulcers, also known as bedsores, are localized skin injuries that can extend to underlying structures like subcutaneous tissue or muscle due to prolonged pressure on a specific area of the body. This pressure impedes blood supply, depriving the affected tissue of nutrients and oxygen, leading to tissue breakdown and ulcer formation over time. Immobilized patients, confined to bed due to various conditions, are highly susceptible to developing pressure ulcers, with approximately 85% attributed to prolonged sitting or lying down. Pressure ulcers near the rectum pose particular challenges as the tissue in this area is prone to acute ischemic injury from external factors like shear forces and compression. Treating pressure ulcers requires a multidimensional approach, focusing on relieving pressure with specialized support surfaces such as pressure-relieving mattresses or cushions, along with regular changes in patient posture to alleviate continuous pressure. Maintaining proper hygiene and wound care is essential to prevent infection, with advanced techniques like dressings, topical medications, and occasional surgical interventions for severe cases. Adequate nutrition and hydration play a vital role in supporting the healing process. Collaborative efforts from healthcare professionals specializing in wound management, nutrition, and physical therapy are often necessary to address the complex nature of pressure ulcers. Prevention through regular assessment, implementing preventive measures such as proper positioning, optimizing nutrition, and providing education to patients and caregivers on skin care and pressure relief techniques are crucial in mitigating pressure ulcer development.
{"title":"Leech Therapy-aided recovery: A case study on accelerated healing of Decubitus ulcers in paraplegic patients","authors":"Yogesh Yadav, Sheetal G. Asutkar","doi":"10.47552/ijam.v15i2.4398","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4398","url":null,"abstract":"Pressure ulcers, also known as bedsores, are localized skin injuries that can extend to underlying structures like subcutaneous tissue or muscle due to prolonged pressure on a specific area of the body. This pressure impedes blood supply, depriving the affected tissue of nutrients and oxygen, leading to tissue breakdown and ulcer formation over time. Immobilized patients, confined to bed due to various conditions, are highly susceptible to developing pressure ulcers, with approximately 85% attributed to prolonged sitting or lying down. Pressure ulcers near the rectum pose particular challenges as the tissue in this area is prone to acute ischemic injury from external factors like shear forces and compression. Treating pressure ulcers requires a multidimensional approach, focusing on relieving pressure with specialized support surfaces such as pressure-relieving mattresses or cushions, along with regular changes in patient posture to alleviate continuous pressure. Maintaining proper hygiene and wound care is essential to prevent infection, with advanced techniques like dressings, topical medications, and occasional surgical interventions for severe cases. Adequate nutrition and hydration play a vital role in supporting the healing process. Collaborative efforts from healthcare professionals specializing in wound management, nutrition, and physical therapy are often necessary to address the complex nature of pressure ulcers. Prevention through regular assessment, implementing preventive measures such as proper positioning, optimizing nutrition, and providing education to patients and caregivers on skin care and pressure relief techniques are crucial in mitigating pressure ulcer development.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4715
Mhaveer Singh, Kamal Yt, Navneet Verma, Arun K. Mishra, Munesh Mani, D. Shukla, S. Ahmad
A crucial and essential prerequisite is the standardization of crude drugs for the purpose of authenticating their effectiveness, safety, and quality. To ensure the scientific significance of two traditional medicinal plants, standardization and quality assessment of two traditional medicines have been done in the current work. The Pharmacognostical evaluation, microscopy, HPTLC profiling, and safety assessment of Amomum subulatum Roxb seed and Cinnamomum cassia Blume leaf have been carried out. The evaluation was carried out by using standard World Health Organization (WHO) protocol along with HPTLC profiling of different extracts by developing suitable solvent systems. Microscopy has been carried out using advanced techniques. The quantitative estimation of harmful heavy metals and aflatoxins is also achieved by using prescribed protocol. The outcomes have been collated and set up in a tabular format for HPTLC profiling and physicochemical evaluation of Cinnamomum cassia and Amomum subulatum. Both the drugs underwent for safety assessment by estimating aflatoxin (B1, B2, and G1, G2) using HPLC, and heavy metals (Lead, Mercury, Cadmium, and Arsenic) by applying atomic absorption spectrometer, whereas pesticidal residue were estimated by using recommended GC-MS method the results have been compared with reference values and discussed, respectively. All the procedures repeated thrice and the average reading with standard deviation has been represented. The recommended standardization methods are valuable for ensuring the scientific significance of herbal drugs. The study demonstrated the microscopic cellular identification of both the plant species, TLC profiling is an acceptable technique to know the phytoconstituents present in particular extracts (polar or non-polar), whereas safety assessment by performing heavy metals, aflatoxins, and pesticide analysis which all collective work can be remarkable for ensuring the quality.
{"title":"Establishment of quality and safety markers for the identification of Amomum seed and Cinnamon leaf","authors":"Mhaveer Singh, Kamal Yt, Navneet Verma, Arun K. Mishra, Munesh Mani, D. Shukla, S. Ahmad","doi":"10.47552/ijam.v15i2.4715","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4715","url":null,"abstract":"A crucial and essential prerequisite is the standardization of crude drugs for the purpose of authenticating their effectiveness, safety, and quality. To ensure the scientific significance of two traditional medicinal plants, standardization and quality assessment of two traditional medicines have been done in the current work. The Pharmacognostical evaluation, microscopy, HPTLC profiling, and safety assessment of Amomum subulatum Roxb seed and Cinnamomum cassia Blume leaf have been carried out. The evaluation was carried out by using standard World Health Organization (WHO) protocol along with HPTLC profiling of different extracts by developing suitable solvent systems. Microscopy has been carried out using advanced techniques. The quantitative estimation of harmful heavy metals and aflatoxins is also achieved by using prescribed protocol. The outcomes have been collated and set up in a tabular format for HPTLC profiling and physicochemical evaluation of Cinnamomum cassia and Amomum subulatum. Both the drugs underwent for safety assessment by estimating aflatoxin (B1, B2, and G1, G2) using HPLC, and heavy metals (Lead, Mercury, Cadmium, and Arsenic) by applying atomic absorption spectrometer, whereas pesticidal residue were estimated by using recommended GC-MS method the results have been compared with reference values and discussed, respectively. All the procedures repeated thrice and the average reading with standard deviation has been represented. The recommended standardization methods are valuable for ensuring the scientific significance of herbal drugs. The study demonstrated the microscopic cellular identification of both the plant species, TLC profiling is an acceptable technique to know the phytoconstituents present in particular extracts (polar or non-polar), whereas safety assessment by performing heavy metals, aflatoxins, and pesticide analysis which all collective work can be remarkable for ensuring the quality.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study focused to assess the dose-dependent hypo-testicular activity of hydro-ethanol seed extract of Areca catechu (10, 20 and 40 mg/ 100 g body weight) in albino rats. For this purpose, body weight, reproductive organo-somatic indices, as well as motility, count, hypo-osmotic swelling and acrosomal cap status of sperm along with the quantity of testicular androgenic key enzyme activities, serum testosterone, oxidative stress sensors, seminal vesicular fructose (SVF), apoptosis linked gene expression study and histology of testicular tissue for spermatokinetics were covered here. All the said doses revealed a significant (p<0.05) downward deviation in spermiological profile, serum testosterone, SVF levels, activities of testicular ∆5,3β and 17β-HSD, seminiferous tubular diameter compared to the vehicle-treated control (VTC). In contrast to the VTC, activities of superoxide dismutase and peroxidase were decreased along with elevation in the levels of thio-barbituric acid reactive substances significantly (p<0.05) in testis and sperm pellet of extract-treated groups. Testicular pro-apoptotic Bax gene expression was elevated and anti-apoptotic Bcl-2 gene expression was diminished significantly (p<0.05) after extract treatment compared to the VTC. Non-significant changes (p>0.05) were noted in hepatic acid and alkaline phosphatase activities which focused the non-toxic characteristics of said extract in general. This study interpreted that, 40 mg showed drastic hypo-testicular efficacy cum necrotic changes compared to other doses though the therapeutic dose that cross the borderline of fertile sensors from spermiological indicators is 20 mg dose. Liquid chromatography-mass spectrometry analysis of the said extract showed that ten phyto-molecules belong to flavonoid, alkaloid and isoflavone groups mainly.
{"title":"Pre-clinical study on hypo-testicular activity of hydro-ethanol (60:40) extract of Areca catechu (L.) in albino rat: Dose-dependent response","authors":"Sukriti Hazra, Dibya Pal, Puja Das, Dipanwita Mitra, Tanusree Mondal, Debidas Ghosh","doi":"10.47552/ijam.v15i2.4669","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4669","url":null,"abstract":"The study focused to assess the dose-dependent hypo-testicular activity of hydro-ethanol seed extract of Areca catechu (10, 20 and 40 mg/ 100 g body weight) in albino rats. For this purpose, body weight, reproductive organo-somatic indices, as well as motility, count, hypo-osmotic swelling and acrosomal cap status of sperm along with the quantity of testicular androgenic key enzyme activities, serum testosterone, oxidative stress sensors, seminal vesicular fructose (SVF), apoptosis linked gene expression study and histology of testicular tissue for spermatokinetics were covered here. All the said doses revealed a significant (p<0.05) downward deviation in spermiological profile, serum testosterone, SVF levels, activities of testicular ∆5,3β and 17β-HSD, seminiferous tubular diameter compared to the vehicle-treated control (VTC). In contrast to the VTC, activities of superoxide dismutase and peroxidase were decreased along with elevation in the levels of thio-barbituric acid reactive substances significantly (p<0.05) in testis and sperm pellet of extract-treated groups. Testicular pro-apoptotic Bax gene expression was elevated and anti-apoptotic Bcl-2 gene expression was diminished significantly (p<0.05) after extract treatment compared to the VTC. Non-significant changes (p>0.05) were noted in hepatic acid and alkaline phosphatase activities which focused the non-toxic characteristics of said extract in general. This study interpreted that, 40 mg showed drastic hypo-testicular efficacy cum necrotic changes compared to other doses though the therapeutic dose that cross the borderline of fertile sensors from spermiological indicators is 20 mg dose. Liquid chromatography-mass spectrometry analysis of the said extract showed that ten phyto-molecules belong to flavonoid, alkaloid and isoflavone groups mainly.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Emotional intelligence (EI) manages emotional disturbances, thereby making a substantive contribution to cognitive aptitude and mental health amelioration among university students. Mindfulness yoga enhances the positive connectivity between mind and emotion, thereby enhancing mental and emotional well-being. The objective of present study is to determine the effectiveness of pranayama and mindfulness (vipassana) meditation on EI among undergraduate (UG) students. Methods: One hundred fifty university students (aged 18-23 years) were employed for this randomised control trial. The students were randomly allocated into two groups: experimental (n=75) and control (n=75). The experimental group practiced daily 60 min intervention of pranayama and mindfulness (vipassana) meditation for 10 weeks. The control group carried out their daily routine activity.Data were analysed through SPSS 24.0, and the repeated measures ANOVA test followed by Bonferroni adjusted post hoc analyses were applied. The participants were accessed for emotional intelligence, anxiety, depression, and stress using standard measures. Results: The findings of the study showed that pranayama and mindfulness (vipassana) meditation practices enhance the level of EI (p<0.001) and manage mental health by decreasing the level of anxiety (p<0.001), depression (p<0.001) and stress (p<0.001) in UG students.These effects were observed within and between groups comparison following the 10 weeks intervention period. Discussion: The study findings emphasise the potential of pranayama and mindfulness (vipassana) meditation practices in positive effects on emotional coping behaviour and mental well-being in students. Conclusion: The study suggests that pranayama and mindfulness (vipassana) meditation can be useful to enhance EI and reduce anxiety, depression, and stress in UG students.
{"title":"Effect of Pranayama and Meditation on Emotional Intelligence among Undergraduate Students: A Randomized Controlled Study","authors":"Jairam Kushwaha, Vatsala Thapliyal, Sachin Kumar Sharma, Ghanshyam Singh Thakur","doi":"10.47552/ijam.v15i2.4476","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4476","url":null,"abstract":"Introduction: Emotional intelligence (EI) manages emotional disturbances, thereby making a substantive contribution to cognitive aptitude and mental health amelioration among university students. Mindfulness yoga enhances the positive connectivity between mind and emotion, thereby enhancing mental and emotional well-being. The objective of present study is to determine the effectiveness of pranayama and mindfulness (vipassana) meditation on EI among undergraduate (UG) students. Methods: One hundred fifty university students (aged 18-23 years) were employed for this randomised control trial. The students were randomly allocated into two groups: experimental (n=75) and control (n=75). The experimental group practiced daily 60 min intervention of pranayama and mindfulness (vipassana) meditation for 10 weeks. The control group carried out their daily routine activity.Data were analysed through SPSS 24.0, and the repeated measures ANOVA test followed by Bonferroni adjusted post hoc analyses were applied. The participants were accessed for emotional intelligence, anxiety, depression, and stress using standard measures. Results: The findings of the study showed that pranayama and mindfulness (vipassana) meditation practices enhance the level of EI (p<0.001) and manage mental health by decreasing the level of anxiety (p<0.001), depression (p<0.001) and stress (p<0.001) in UG students.These effects were observed within and between groups comparison following the 10 weeks intervention period. Discussion: The study findings emphasise the potential of pranayama and mindfulness (vipassana) meditation practices in positive effects on emotional coping behaviour and mental well-being in students. Conclusion: The study suggests that pranayama and mindfulness (vipassana) meditation can be useful to enhance EI and reduce anxiety, depression, and stress in UG students.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4525
Carolin Paul, Mariappan A
Siddha system of medicine is one of the holistic systems. The consumption of traditional medicine is also in upward trend. To manufacture any herbal drug the quality and safety of the drug is to be estimated. Karanthai legium (KL) is one of the herbomineral formulation indicated for kiranthi (Skin disease), karappan (Eczema), soolai (Pain), yoni putru (Cervical cancer), kunmam (Ulcer). This study aims to develop standardization of Karanthai legium as per PLIM (Pharmacopeia Laboratory of Indian Medicine) guidelines. The test drug KL focused on Physico-chemical analysis, Phytochemical Analysis, Oraganoleptic character, Instrumental analysis such as heavy metal analysis, HPTLC Analysis, Aflatoxin, Pesticide residue, Specific pathogen and Microbial contamination. Physiochemical analysis report showed loss of drying KL is 14.96%, total ash is 0.92%, acid insoluble ash is 0.17%, water soluble ash is 0.50%,pH of KL is 5.45.The drug KL had HPTLC fingerprint analysis revealed the presence of nine phytocomponents at 254nm, eight phytocomponents at 366nm and six phytocomponents at 520nm.The heavy metal analysis showed no trace of heavy metal residue in KL. This study revealed the data regarding the physicochemical characterisation of Karanthai legium, which will be helpful in standardising the drugs and for further comparison studies.
{"title":"Physiochemical and phytochemical analysis of Karanthai legium - Siddha herbomineral formulation","authors":"Carolin Paul, Mariappan A","doi":"10.47552/ijam.v15i2.4525","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4525","url":null,"abstract":"Siddha system of medicine is one of the holistic systems. The consumption of traditional medicine is also in upward trend. To manufacture any herbal drug the quality and safety of the drug is to be estimated. Karanthai legium (KL) is one of the herbomineral formulation indicated for kiranthi (Skin disease), karappan (Eczema), soolai (Pain), yoni putru (Cervical cancer), kunmam (Ulcer). This study aims to develop standardization of Karanthai legium as per PLIM (Pharmacopeia Laboratory of Indian Medicine) guidelines. The test drug KL focused on Physico-chemical analysis, Phytochemical Analysis, Oraganoleptic character, Instrumental analysis such as heavy metal analysis, HPTLC Analysis, Aflatoxin, Pesticide residue, Specific pathogen and Microbial contamination. Physiochemical analysis report showed loss of drying KL is 14.96%, total ash is 0.92%, acid insoluble ash is 0.17%, water soluble ash is 0.50%,pH of KL is 5.45.The drug KL had HPTLC fingerprint analysis revealed the presence of nine phytocomponents at 254nm, eight phytocomponents at 366nm and six phytocomponents at 520nm.The heavy metal analysis showed no trace of heavy metal residue in KL. This study revealed the data regarding the physicochemical characterisation of Karanthai legium, which will be helpful in standardising the drugs and for further comparison studies.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4306
Utkarsha Kandalkar, Anita Wanjari, B. Rathi, Harlin Swer, Anjali Katore
Vidarikandadi Churna (VC) is a Polyherbal formulation suggested for karshya that is also said to be beneficial for weight gain and development. Yogaratnakara mentions Vidarikandadi churna as a formulation. Many formulations are cited for their nootropic and antioxidant qualities. Vidarikandadi Churna is one of the preparations. Traditional meals are high in the nutrients that growing children require. On Wistar male rats, we conducted a research to examine the strength, stamina, and growth-promoting abilities of conventional supplements and traditional health supplements. Aim: Pharmaceutical analytical study of Vidarikandadi Churna and its modified dosage form and assessment of their comparative efficacy for Strength, Stamina, and Growth as compared to standard supplements in albino rats. Objectives: To assess and compare the strength, stamina, and growth parameters in VC, VB, and standard supplements. Material and Methods: A total of 30 Wistar male rats were used in the study. Five groupings of animals were formed. Except for the Normal control group, all of the rats were given health supplements. For 30 days, groups II, III, IV, and V received Milk, Complan, Vidarikandadi Churna, and Vidarikandadi Biscuits but no health supplement (control group). A swim endurance test was used to assess the strength and stamina of Wistar rats in each group, and growth was assessed by measuring body length and body weight. Observation and Results: A group of rats with the greatest development (body length and weight), strength, and stamina were studied. Group V rats had the most strength and stamina, followed by Group IV, Group III, and Group II rats. Group V rats gained the most, followed by groups IV, III, and II, in that order. Conclusion: In the current study, we discovered that group V rats had the most strength and stamina, followed by groups IV, III, and II, and that group V rats had the greatest growth, followed by groups IV, III, and II, respectively.
Vidarikandadi Churna（VC）是一种多草药配方，建议用于卡西亚，据说对体重增加和发育也有好处。Yogaratnakara 提到 Vidarikandadi Churna 是一种配方。许多配方都具有提高记忆力和抗氧化的功效。Vidarikandadi Churna 就是其中之一。传统膳食富含成长中的儿童所需的营养成分。我们以 Wistar 雄性大鼠为研究对象，对传统保健品和传统保健品的力量、耐力和促进生长能力进行了研究。目的：对 Vidarikandadi Churna 及其改进剂型进行药物分析研究，并评估其与标准保健品相比对白化大鼠力量、耐力和生长的比较功效。目的评估和比较 VC、VB 和标准补充剂的力量、耐力和生长参数。材料与方法本研究共使用了 30 只 Wistar 雄性大鼠。动物分为五组。除正常对照组外，所有大鼠均服用保健品。II、III、IV 和 V 组在 30 天内服用牛奶、康普兰、Vidarikandadi Churna 和 Vidarikandadi 饼干，但不服用保健品（对照组）。游泳耐力测试用于评估各组 Wistar 大鼠的力量和耐力，生长情况则通过测量体长和体重来评估。观察结果对发育（体长和体重）、力量和耐力最好的一组大鼠进行了研究。第五组大鼠的力量和耐力最强，其次是第四组、第三组和第二组大鼠。第五组大鼠的体重增加最多，其次依次是第四组、第三组和第二组。结论在本次研究中，我们发现第 V 组大鼠的力量和耐力最强，其次是第 IV 组、第 III 组和第 II 组；第 V 组大鼠的生长速度最快，其次分别是第 IV 组、第 III 组和第 II 组。
{"title":"Evaluation of Comparative Efficacy of Vidarikandadi Churna and its Modified Dosage Form for Assessment of Growth, Strength, and Stamina in Albino Rats","authors":"Utkarsha Kandalkar, Anita Wanjari, B. Rathi, Harlin Swer, Anjali Katore","doi":"10.47552/ijam.v15i2.4306","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4306","url":null,"abstract":"Vidarikandadi Churna (VC) is a Polyherbal formulation suggested for karshya that is also said to be beneficial for weight gain and development. Yogaratnakara mentions Vidarikandadi churna as a formulation. Many formulations are cited for their nootropic and antioxidant qualities. Vidarikandadi Churna is one of the preparations. Traditional meals are high in the nutrients that growing children require. On Wistar male rats, we conducted a research to examine the strength, stamina, and growth-promoting abilities of conventional supplements and traditional health supplements. Aim: Pharmaceutical analytical study of Vidarikandadi Churna and its modified dosage form and assessment of their comparative efficacy for Strength, Stamina, and Growth as compared to standard supplements in albino rats. Objectives: To assess and compare the strength, stamina, and growth parameters in VC, VB, and standard supplements. Material and Methods: A total of 30 Wistar male rats were used in the study. Five groupings of animals were formed. Except for the Normal control group, all of the rats were given health supplements. For 30 days, groups II, III, IV, and V received Milk, Complan, Vidarikandadi Churna, and Vidarikandadi Biscuits but no health supplement (control group). A swim endurance test was used to assess the strength and stamina of Wistar rats in each group, and growth was assessed by measuring body length and body weight. Observation and Results: A group of rats with the greatest development (body length and weight), strength, and stamina were studied. Group V rats had the most strength and stamina, followed by Group IV, Group III, and Group II rats. Group V rats gained the most, followed by groups IV, III, and II, in that order. Conclusion: In the current study, we discovered that group V rats had the most strength and stamina, followed by groups IV, III, and II, and that group V rats had the greatest growth, followed by groups IV, III, and II, respectively.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141659104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4433
Khushhali Balpande, Sadhana Misar, Praveen Nandal
In Ayurveda skin disorders are mentioned under Kushtharogaadhikar and categorized into seven Mahakushthas and eleven Kshudrakushthas. Among all the Kshudrakushthas, Kitibhakushtha is one of the types. Sign & Symptoms of Kitibhakushtha are Kina Khara Sparsham (rough on touch), Shyava Varna (blackish brown color) and Kandu (itching). It is a Tridoshaja with the predominance of Vata-Kapha along with the involvement of Twak, Rakta, Mamsa and Lasika in the Samprapti. Nidanas of KitibhaKushtha are Aaharaj, Viharaj, Upsargaja and Krimija. KitibhaKushtha can be correlated with psoriasis due to similarities in symptoms. Aim and objectives: -Evaluation of comparative efficacy of Chakramarda ointment versus Psoralin ointment with capsule Guduchi internally in the management of Kitibha Kushtha (Psoriasis). Material and Methods - This study comprises a total of 60 patients in which patients in Group A were treated with Chakramarda ointment once daily in the morning after bath and 2 Guduchi capsules 500mg thrice a day internally whereas patients in Group B were treated with Psoralin ointment once daily in the morning after bath and 2 Guduchi capsules 500 mg thrice a day internally for 30 days. Patients were assessed for subjective parameters like Kandu, Shyav Krishna Varna and Rookshata and objective parameter PASI scale. Result – Significant improvement was observed in Subjective and Objective parameters. Conclusion- Chakramarda ointment is as efficacious as Psoralin ointment in the treatment of KitibhaKushtha. Hence Kitibha Kushtha can be effectively managed with Chakramarda ointment.
{"title":"Comparative evaluation of Chakramarda ointment and Psoralin ointment along with Guduchi capsule in the management of KitibhaKushtha (Psoriasis)","authors":"Khushhali Balpande, Sadhana Misar, Praveen Nandal","doi":"10.47552/ijam.v15i2.4433","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4433","url":null,"abstract":"In Ayurveda skin disorders are mentioned under Kushtharogaadhikar and categorized into seven Mahakushthas and eleven Kshudrakushthas. Among all the Kshudrakushthas, Kitibhakushtha is one of the types. Sign & Symptoms of Kitibhakushtha are Kina Khara Sparsham (rough on touch), Shyava Varna (blackish brown color) and Kandu (itching). It is a Tridoshaja with the predominance of Vata-Kapha along with the involvement of Twak, Rakta, Mamsa and Lasika in the Samprapti. Nidanas of KitibhaKushtha are Aaharaj, Viharaj, Upsargaja and Krimija. KitibhaKushtha can be correlated with psoriasis due to similarities in symptoms. Aim and objectives: -Evaluation of comparative efficacy of Chakramarda ointment versus Psoralin ointment with capsule Guduchi internally in the management of Kitibha Kushtha (Psoriasis). \u0000Material and Methods - This study comprises a total of 60 patients in which patients in Group A were treated with Chakramarda ointment once daily in the morning after bath and 2 Guduchi capsules 500mg thrice a day internally whereas patients in Group B were treated with Psoralin ointment once daily in the morning after bath and 2 Guduchi capsules 500 mg thrice a day internally for 30 days. Patients were assessed for subjective parameters like Kandu, Shyav Krishna Varna and Rookshata and objective parameter PASI scale. Result – Significant improvement was observed in Subjective and Objective parameters. Conclusion- Chakramarda ointment is as efficacious as Psoralin ointment in the treatment of KitibhaKushtha. Hence Kitibha Kushtha can be effectively managed with Chakramarda ointment.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4549
Rakhi Bhattacharyya, Selim Mehmud, K. K. Medhi, Sarat Borkataki
The present study deals with the documentation of ethnomedicinal plants used against rheumatoid arthritis by the tea tribe community of Morigaon district of Assam. The tea tribes of the district still rely on herbal remedies for curing rheumatoid arthritis. To document the plant species used by tea tribes against rheumatoid arthritis, frequent study field surveys were conducted in different places of the district. A semi-structured questionnaire on traditional knowledge was used to elicit information from the concerned tribe of the study area. The documented data was evaluated using quantitative ethnobotanical indices like Use Value (UV) and Fidelity Level Percentage (FL %). From the study, a total of 33 plants belonging to 32 genera under 24 families were documented. The data was evaluated using quantitative ethnobotanical indices like Use Value and Fidelity Level Percentage. Five species were found having the highest use value and four species showed fidelity levels of 100 %. Further research is required to investigate the pharmacological effects and the chemical constituents present in the plant species that could be the basis for developing some novel product in the future.
{"title":"A report on ethnomedicinal plants used for the treatment of Rheumatoid arthritis by the tea tribes of Morigaon district of Assam, India","authors":"Rakhi Bhattacharyya, Selim Mehmud, K. K. Medhi, Sarat Borkataki","doi":"10.47552/ijam.v15i2.4549","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4549","url":null,"abstract":"The present study deals with the documentation of ethnomedicinal plants used against rheumatoid arthritis by the tea tribe community of Morigaon district of Assam. The tea tribes of the district still rely on herbal remedies for curing rheumatoid arthritis. To document the plant species used by tea tribes against rheumatoid arthritis, frequent study field surveys were conducted in different places of the district. A semi-structured questionnaire on traditional knowledge was used to elicit information from the concerned tribe of the study area. The documented data was evaluated using quantitative ethnobotanical indices like Use Value (UV) and Fidelity Level Percentage (FL %). From the study, a total of 33 plants belonging to 32 genera under 24 families were documented. The data was evaluated using quantitative ethnobotanical indices like Use Value and Fidelity Level Percentage. Five species were found having the highest use value and four species showed fidelity levels of 100 %. Further research is required to investigate the pharmacological effects and the chemical constituents present in the plant species that could be the basis for developing some novel product in the future.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.47552/ijam.v15i2.4422
Tejas Kumbhar, Pallavi Chiprikar, A. Ammanage, Umeshkumar Patel, V. Mastiholimath
The aim of study is to formulate and evaluate polyherbal suspension containing aqueous extracts of Cassia Fistula L, Terminalia Bellerica Gaertn, Terminalia Chebula Retzm, Operculina Turpethum L, and Baliospermum Montanum Muell for laxative use and develop a validated analytical method by HPLC. The excipients employed in the formulation were Sucrose, Xanthan gum, Tween 80, Sodium methylparaben, Sodium propylparaben and water. The suspension was evaluated for organoleptic properties, Sedimentation volume, Redispersibility, Flow rate, Viscosity, and pH. Optimized formulation was further evaluated to check its stability for 90 days in accelerated conditions. The analytical method was developed for the assay of Rhein in formulated polyherbal suspension and validated by HPLC (Waters instrument with Empower software). The results revealed that an increased concentration of suspending agent increased viscosity, thus reducing the sedimentation and improving the stability of suspension. The validation parameters results indicated that the developed method is simple, reproducible, accurate, robust, precise, and specific. Polyherbal suspension was successfully formulated using varying concentrations of suspending agent and wetting agent by employing a 32 factorial design. The validation results obtained for the assay of rhein in polyherbal formulation showed that the developed HPLC method was precise and accurate.
{"title":"Formulation and Analytical Development of Laxative Polyherbal Suspension","authors":"Tejas Kumbhar, Pallavi Chiprikar, A. Ammanage, Umeshkumar Patel, V. Mastiholimath","doi":"10.47552/ijam.v15i2.4422","DOIUrl":"https://doi.org/10.47552/ijam.v15i2.4422","url":null,"abstract":"The aim of study is to formulate and evaluate polyherbal suspension containing aqueous extracts of Cassia Fistula L, Terminalia Bellerica Gaertn, Terminalia Chebula Retzm, Operculina Turpethum L, and Baliospermum Montanum Muell for laxative use and develop a validated analytical method by HPLC. The excipients employed in the formulation were Sucrose, Xanthan gum, Tween 80, Sodium methylparaben, Sodium propylparaben and water. The suspension was evaluated for organoleptic properties, Sedimentation volume, Redispersibility, Flow rate, Viscosity, and pH. Optimized formulation was further evaluated to check its stability for 90 days in accelerated conditions. The analytical method was developed for the assay of Rhein in formulated polyherbal suspension and validated by HPLC (Waters instrument with Empower software). The results revealed that an increased concentration of suspending agent increased viscosity, thus reducing the sedimentation and improving the stability of suspension. The validation parameters results indicated that the developed method is simple, reproducible, accurate, robust, precise, and specific. Polyherbal suspension was successfully formulated using varying concentrations of suspending agent and wetting agent by employing a 32 factorial design. The validation results obtained for the assay of rhein in polyherbal formulation showed that the developed HPLC method was precise and accurate. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141661265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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