A quick, accurate, and cost-effective UV spectroscopy method was developed to estimate the Vinpocetine concentration in bulk, tablet dosage formulations and niosomes formulations, using a solvent ratio of (6:4) methanol: water. According to ICH guidelines, the proposed technique was validated and developed. In spite of linearity, precision, accuracy, specificity, LOD, and LOQ, like parameters were validated by using UV/visible spectroscopy technique to analyze a spiked Vinpocetine solution. The wavelength at which the drug's maximum absorbance peak was obtained at 274 nm and the solvents used as methanol: water (6:4 w/v). The ethanol injection technique was used to prepare niosomes to analyze Vinpocetine in UV / visible spectrophotometric method.During the inter and intra-day studies, it was discovered that the developed UV technique was accurate, with % relative standard deviation ranging from 0.27 to 0.46 and 0.26 to 0.46, respectively. Vinpocetine overall recovery percentage was discovered to be between 98.42 to 99.82 %. LOQ and LOD were calculated to estimate the method's sensitivity, and they were observed to be 0.4565 µg/ml and 0.1506 µg/ml, respectively. The estimation of Vinpocetine content in bulk form, marketed formulations and niosomes was achieved using the developed methodology. : A quick, accurate, and economical UV spectrophotometric method has been developed. As a result, the suggested UV spectroscopic technique has been developed to estimate the vinpocetine concentration in bulk, tablet dosage formulations, and niosomes formulations.
{"title":"Development and Validation of UV-Spectrophotometric Method for Estimation of Vinpocetine in Marketed Formulation and Nanoformulation","authors":"Chethan Kumar HB, Bhaskar Kurangi, Moazzim Soudagar, Supriya Chimagave, Swapnil Patil","doi":"10.47552/ijam.v14i3.3585","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3585","url":null,"abstract":"A quick, accurate, and cost-effective UV spectroscopy method was developed to estimate the Vinpocetine concentration in bulk, tablet dosage formulations and niosomes formulations, using a solvent ratio of (6:4) methanol: water. According to ICH guidelines, the proposed technique was validated and developed. In spite of linearity, precision, accuracy, specificity, LOD, and LOQ, like parameters were validated by using UV/visible spectroscopy technique to analyze a spiked Vinpocetine solution. The wavelength at which the drug's maximum absorbance peak was obtained at 274 nm and the solvents used as methanol: water (6:4 w/v). The ethanol injection technique was used to prepare niosomes to analyze Vinpocetine in UV / visible spectrophotometric method.During the inter and intra-day studies, it was discovered that the developed UV technique was accurate, with % relative standard deviation ranging from 0.27 to 0.46 and 0.26 to 0.46, respectively. Vinpocetine overall recovery percentage was discovered to be between 98.42 to 99.82 %. LOQ and LOD were calculated to estimate the method's sensitivity, and they were observed to be 0.4565 µg/ml and 0.1506 µg/ml, respectively. The estimation of Vinpocetine content in bulk form, marketed formulations and niosomes was achieved using the developed methodology. : A quick, accurate, and economical UV spectrophotometric method has been developed. As a result, the suggested UV spectroscopic technique has been developed to estimate the vinpocetine concentration in bulk, tablet dosage formulations, and niosomes formulations.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: The liver is particularly vulnerable to oxidative stress brought on by hyperglycemia since it is the main tissue. In order to better understand how Ventilago maderaspatana leaf methanolic extract (MEVML) affects liver function markers and the histology of liver tissue in STZ-induced diabetic rats, this study looked into the hepatoprotective potential of MEVML. Method: A single STZ dose of 50 mg/kg body weight was given to the animals to cause diabetes. All of the experimental groups' serum was tested for levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), and urea content. Results: The results revealed a marked increase in the serum levels of urea, ALT, AST, ALP, and GGT activity. The results of MEVML treatment, however, were equivalent to those of glibenclamide treatment in that they led to a decline in the activity of ALT, ALP, AST, GGT, and urea content in the diabetic group of rats. Furthermore, diabetic rats' liver tissue showed considerable histological alterations. However, treatment with Ventilago maderaspatana methanolic leaf extract and glibenclamide considerably reduced these histological alterations. Conclusion: Overall, the findings of our study show that MEVML reduces liver function biomarkers and restores the architecture of hepatic tissue to reduce hepatic tissue damage under diabetes stress conditions.
{"title":"Effect of methanolic extract of Ventilago maderaspatana leaves on liver function markers and histopathology of liver tissue in streptozotocin-induced diabetic rats","authors":"Venugopal Reddy Boreddy, Lavanya Thopireddy, Sathyavelu Reddy Kesireddy, Rajeswara Reddy Saddala","doi":"10.47552/ijam.v14i3.3962","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3962","url":null,"abstract":"Aim: The liver is particularly vulnerable to oxidative stress brought on by hyperglycemia since it is the main tissue. In order to better understand how Ventilago maderaspatana leaf methanolic extract (MEVML) affects liver function markers and the histology of liver tissue in STZ-induced diabetic rats, this study looked into the hepatoprotective potential of MEVML. Method: A single STZ dose of 50 mg/kg body weight was given to the animals to cause diabetes. All of the experimental groups' serum was tested for levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), and urea content. Results: The results revealed a marked increase in the serum levels of urea, ALT, AST, ALP, and GGT activity. The results of MEVML treatment, however, were equivalent to those of glibenclamide treatment in that they led to a decline in the activity of ALT, ALP, AST, GGT, and urea content in the diabetic group of rats. Furthermore, diabetic rats' liver tissue showed considerable histological alterations. However, treatment with Ventilago maderaspatana methanolic leaf extract and glibenclamide considerably reduced these histological alterations. Conclusion: Overall, the findings of our study show that MEVML reduces liver function biomarkers and restores the architecture of hepatic tissue to reduce hepatic tissue damage under diabetes stress conditions.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3683
Ibamedabha Japang, Renu B Rathi, Bharat Rathi, Jitesh Varma
Background: A child with global developmental delay is unable to attain developmental milestones owing to brain damage which leads to impairment in gross and fine motor, personal social, speech, and activities of daily living (ADL). Aim and objectives:To evaluate the effectiveness of panchakarma procedures in a child with global developmental delay. Materials & Methods:A 3-year-old boy was diagnosed with neuroblastoma and had undergone surgery 2 year back. His parents approached us with complaints of being unable to stand,walk,talk, & ataxia after surgery.There was a significant loss of gross motor function and strength in the lower and upper limbs. The patient underwent treatment with Shaman Chikitsa (medicine interventions) followed by Bhrimhana Chikitsa. In his 1st sitting, Sarvanaga Abhyanga, pratimarsha Nasya, Shashtika-Shali-Pinda Swedana, Shirodhara, and matra Basti were given for 15 days. Observations and Result:Assessment was done with standard developmental delay parameters i.e GMFCS-Gross motor function classification system. Significant improvement were observed in the domains of gross motor, fine motor, personal-social and language milestones before and after treatment. Discussion:Elimination of vataprakop is the first line of treatment, this is done by shamana and panchakarma bhrimhana Chikitsa. By combining the shamana, panchakarma and physiotherapy a significant improvement was observed, especially in the gross motor milestones as per GMFCS, sitting from grade-2 before treatment to grade-4 after treatment, in standing from grade-0 to grade-2, fine motor from grade-1 to grade-3, language from grade-2 to grade-4, personal & social from grade-2 to grade-5. Conclusion:In a nutshell, GDD can be managed by multimodal interventions such as Ayurveda procedures, medicines, and physiotherapy.
{"title":"Ayurveda Management of Global Developmental Delay (Bala Samvardhan Janya Vatavikruti) by collaborative approach of Shaman and Bhrimhana Chikitsa in Ayurveda-A Case Report","authors":"Ibamedabha Japang, Renu B Rathi, Bharat Rathi, Jitesh Varma","doi":"10.47552/ijam.v14i3.3683","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3683","url":null,"abstract":"Background: A child with global developmental delay is unable to attain developmental milestones owing to brain damage which leads to impairment in gross and fine motor, personal social, speech, and activities of daily living (ADL). Aim and objectives:To evaluate the effectiveness of panchakarma procedures in a child with global developmental delay. Materials & Methods:A 3-year-old boy was diagnosed with neuroblastoma and had undergone surgery 2 year back. His parents approached us with complaints of being unable to stand,walk,talk, & ataxia after surgery.There was a significant loss of gross motor function and strength in the lower and upper limbs. The patient underwent treatment with Shaman Chikitsa (medicine interventions) followed by Bhrimhana Chikitsa. In his 1st sitting, Sarvanaga Abhyanga, pratimarsha Nasya, Shashtika-Shali-Pinda Swedana, Shirodhara, and matra Basti were given for 15 days. Observations and Result:Assessment was done with standard developmental delay parameters i.e GMFCS-Gross motor function classification system. Significant improvement were observed in the domains of gross motor, fine motor, personal-social and language milestones before and after treatment. Discussion:Elimination of vataprakop is the first line of treatment, this is done by shamana and panchakarma bhrimhana Chikitsa. By combining the shamana, panchakarma and physiotherapy a significant improvement was observed, especially in the gross motor milestones as per GMFCS, sitting from grade-2 before treatment to grade-4 after treatment, in standing from grade-0 to grade-2, fine motor from grade-1 to grade-3, language from grade-2 to grade-4, personal & social from grade-2 to grade-5. Conclusion:In a nutshell, GDD can be managed by multimodal interventions such as Ayurveda procedures, medicines, and physiotherapy.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Pruthvisara taila is Niragni snehapaka (Aditya paka taila). It is indicated in Kushta and Vruna, mentionedby classical text Chakradatta. AIM: An attempt was made to prepare Pruthvisara taila by two methods and analyse the difference between both the samples on the basis of organoleptic characters and physico-chemical parameters. Methodology: In pharmaceutical study, the Pruthvisara taila was prepared by both methods; Niragni (Aditya paka-sunlight as source of heat)and Sagni) using fire as source of heat) & in analytical study both the samples were subjected for physicochemical analysis like pH, Viscosity, Refractive index, Specific Gravity, Acid Value, Iodine value, Saponification Value, Unsaponifiable matter,Peroxide value and Rancidity. Results: Results of the study on the parameters assessed on the samples after preparation by both the methods;duration required for the preparation of Aditya paka Pruthvisara taila is 24 days and for Sagni Pruthvisara taila is 5 days.Viscosity of NPT(Niragni Pruthvisara taila) was 127.1497 and SPT (Sagni Pruthvisara taila) 89.3996, refractive index was 1.47807 w/w and 1.47607 w/w respectively. The specific gravity of NPT and SPT were 0.9142w/w and 0.8866 w/w respectively. Acid value is more in SPT (108.46 w/w) as compared to NPT (62.76w/w). Iodine value is more in SPT (245.34w/w) as compared to NPT (58.37).The SPT(222.75 w/w) sample has got more saponification value than NPT (200.75w/w). The unsaponifiable matter in NPT has 1.84% and SPT has 4.80%. Conclusion: Acid value indicates about the short shelf life of the drug, which was comparatively more in Sagni Pruthvisara taila than Niragni Pruthvisara taila, hence the early chances of rancidity are more in SPT.Percentage of saturated and long chain fatty acids are more in Niragni Pruthvisara taila when compared to Sagni Pruthvisara taila which was revealed through iodine value and saponification value. Hence the NPT is less susceptible to oxidation and rancidity.
{"title":"Comparative analytical evaluation of Pruthvisara taila prepared by two different methods","authors":"Archana Pagad, Abhaya Kumar Mishra, Gazala Hussain","doi":"10.47552/ijam.v14i3.3856","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3856","url":null,"abstract":"Background: Pruthvisara taila is Niragni snehapaka (Aditya paka taila). It is indicated in Kushta and Vruna, mentionedby classical text Chakradatta. AIM: An attempt was made to prepare Pruthvisara taila by two methods and analyse the difference between both the samples on the basis of organoleptic characters and physico-chemical parameters. Methodology: In pharmaceutical study, the Pruthvisara taila was prepared by both methods; Niragni (Aditya paka-sunlight as source of heat)and Sagni) using fire as source of heat) & in analytical study both the samples were subjected for physicochemical analysis like pH, Viscosity, Refractive index, Specific Gravity, Acid Value, Iodine value, Saponification Value, Unsaponifiable matter,Peroxide value and Rancidity. Results: Results of the study on the parameters assessed on the samples after preparation by both the methods;duration required for the preparation of Aditya paka Pruthvisara taila is 24 days and for Sagni Pruthvisara taila is 5 days.Viscosity of NPT(Niragni Pruthvisara taila) was 127.1497 and SPT (Sagni Pruthvisara taila) 89.3996, refractive index was 1.47807 w/w and 1.47607 w/w respectively. The specific gravity of NPT and SPT were 0.9142w/w and 0.8866 w/w respectively. Acid value is more in SPT (108.46 w/w) as compared to NPT (62.76w/w). Iodine value is more in SPT (245.34w/w) as compared to NPT (58.37).The SPT(222.75 w/w) sample has got more saponification value than NPT (200.75w/w). The unsaponifiable matter in NPT has 1.84% and SPT has 4.80%. Conclusion: Acid value indicates about the short shelf life of the drug, which was comparatively more in Sagni Pruthvisara taila than Niragni Pruthvisara taila, hence the early chances of rancidity are more in SPT.Percentage of saturated and long chain fatty acids are more in Niragni Pruthvisara taila when compared to Sagni Pruthvisara taila which was revealed through iodine value and saponification value. Hence the NPT is less susceptible to oxidation and rancidity.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3655
Hemaxi Mankodi, Shukla V J, Patgiri B J
The traditional drug manufacturing process involves numerous qualitative attributes that directly impact product quality. The Process Analytical Technology approach considers that to enhance process control, identifying critical process parameters and critical quality attributes that affect the manufacturing process is very much necessary. The Ayurvedic drug manufacturing process is more driven by fuzzy qualitative attributes. The present study was executed to identify the Critical Process Parameters and Critical Quality Attributes in the manufacturing process of a herbo-mineral formulation, viz. Arogyavardhini Rasa. Fuzzy set Qualitative Comparative Analysis (fsQCA) methodology was adopted to observe and identify the critical parameters. The study was executed in three steps, viz. Data collection, Data arrangement, and Analysis. The raw data collected was arranged and analyzed in the software R studio using the package QCA in four steps, viz. Calibration, Analysis of Necessity and Sufficiency, Truth Table construction, and Minimization. The results obtained show that Size reduction, Mardana, and Drying are the identified Critical Process Parameters that, in combination, lead to the outcome, i.e., good product quality. Thus, this study proves that Fuzzy Set Qualitative Comparative Analysis can be used as an efficient tool for the identification and measurement of the Critical Process Parameters that affect the Critical Quality Attributes and, thereby, the product quality in the manufacturing of Arogyavardhini Rasa.
{"title":"Fuzzy Set Qualitative methodology for identifying the Critical Process Parameters and Quality attributes in the manufacturing of Arogyavardhini Rasa","authors":"Hemaxi Mankodi, Shukla V J, Patgiri B J","doi":"10.47552/ijam.v14i3.3655","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3655","url":null,"abstract":"The traditional drug manufacturing process involves numerous qualitative attributes that directly impact product quality. The Process Analytical Technology approach considers that to enhance process control, identifying critical process parameters and critical quality attributes that affect the manufacturing process is very much necessary. The Ayurvedic drug manufacturing process is more driven by fuzzy qualitative attributes. The present study was executed to identify the Critical Process Parameters and Critical Quality Attributes in the manufacturing process of a herbo-mineral formulation, viz. Arogyavardhini Rasa. Fuzzy set Qualitative Comparative Analysis (fsQCA) methodology was adopted to observe and identify the critical parameters. The study was executed in three steps, viz. Data collection, Data arrangement, and Analysis. The raw data collected was arranged and analyzed in the software R studio using the package QCA in four steps, viz. Calibration, Analysis of Necessity and Sufficiency, Truth Table construction, and Minimization. The results obtained show that Size reduction, Mardana, and Drying are the identified Critical Process Parameters that, in combination, lead to the outcome, i.e., good product quality. Thus, this study proves that Fuzzy Set Qualitative Comparative Analysis can be used as an efficient tool for the identification and measurement of the Critical Process Parameters that affect the Critical Quality Attributes and, thereby, the product quality in the manufacturing of Arogyavardhini Rasa.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3684
Aishwarya Gajanan Masal, Arati Abhay Shinde
Ayurveda is an ancient science dominantly focuses on healthy living and mindful life in contrary to other medical sciences. Ayurveda specifically uses herbs and herbo-mineral combinations for the treatment. The herbs described in the classics also include some Vishadravya (poisonous plants) as potent medicine. Anything that results in "Vishannatva" (stress) or "Vishada" (sadness) in the body is "Visha" (poisonous material). Depending on the intensity of toxicity, Ayurvedic classics have classified all poisons into two categories: Mahavisha and Upavisha (less potent toxin). Vatsanabha (Aconitum ferox Wall. ex Seringe) is classified under the Sthavara Visha (poison of plant origin) and Mahavisha. It is the only Mahavisha that is still recognised and available. All Vishadravya should be used after some specific Shodhana (purification). While administering Vatsanabha in the form of Ayurvedic medicines, Shodhana (purification) is an effective technique for minimising its hazardous effects. Although it is Vishadravya, the compounds containing Vatsanabha (Aconitum ferox Wall. ex Seringe) are listed in ‘Essential Ayurveda Medication for Ayurvedic dispensaries, operated under centrally supported programmes of the Government of India. This enlistment affirms its significance in other ways. Nearly 17 percentage of the formulations mentioned in RRS have Vatsanabha as their constituent. Modern research has already proven the analgesic, antipyretic, antioxidant, antimicrobial and many other activities of Vatsanabha. Thus, the present review is designed to extensively discuss and understand the safety profile of Vatsanabha and utility in various diseases, along with its probable mode of action.
{"title":"Vatsanabha (Aconitum ferox Wall. ex Seringe): A known Visha but potent medicine W.S.R. Rasa Ratna Samuchchaya","authors":"Aishwarya Gajanan Masal, Arati Abhay Shinde","doi":"10.47552/ijam.v14i3.3684","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3684","url":null,"abstract":"Ayurveda is an ancient science dominantly focuses on healthy living and mindful life in contrary to other medical sciences. Ayurveda specifically uses herbs and herbo-mineral combinations for the treatment. The herbs described in the classics also include some Vishadravya (poisonous plants) as potent medicine. Anything that results in \"Vishannatva\" (stress) or \"Vishada\" (sadness) in the body is \"Visha\" (poisonous material). Depending on the intensity of toxicity, Ayurvedic classics have classified all poisons into two categories: Mahavisha and Upavisha (less potent toxin). Vatsanabha (Aconitum ferox Wall. ex Seringe) is classified under the Sthavara Visha (poison of plant origin) and Mahavisha. It is the only Mahavisha that is still recognised and available. All Vishadravya should be used after some specific Shodhana (purification). While administering Vatsanabha in the form of Ayurvedic medicines, Shodhana (purification) is an effective technique for minimising its hazardous effects. Although it is Vishadravya, the compounds containing Vatsanabha (Aconitum ferox Wall. ex Seringe) are listed in ‘Essential Ayurveda Medication for Ayurvedic dispensaries, operated under centrally supported programmes of the Government of India. This enlistment affirms its significance in other ways. Nearly 17 percentage of the formulations mentioned in RRS have Vatsanabha as their constituent. Modern research has already proven the analgesic, antipyretic, antioxidant, antimicrobial and many other activities of Vatsanabha. Thus, the present review is designed to extensively discuss and understand the safety profile of Vatsanabha and utility in various diseases, along with its probable mode of action.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3568
Akib Ali, Debashish Khanikar, Bidisha Kataki
Natural products derived from plants have essential biological parts in contradiction of many pathogenic organisms and are considered a principal source of modern synthetic drugs. A thorough field survey of ethnomedicinal plants was conducted between the months of July, 2022 to December, 2022 in three districts of Assam, namely Nalbari, Sonitpur and Tinsukia. Indigenous knowledge of the traditional medicines used for Urinary Tract Infection (UTI), Urinary Tract stones or kidney stones were gathered based on personal interviews and questionnaires. Medicinal plants with their family, local names, parts used and target diseases were documented. A total of 51 species were documented; of which, amaranthaceae family showed the highest number of species (6), followed by malvaceae (4), fabaceae (3), euphorbiaceae (3), asteraceae (3) etc. This survey revealed several effective medicinal plants that have significant pharmacogenetic properties, especially for UTI and kidney diseases.
{"title":"A Survey of Ethnomedicinal Plants used for Urinary Tract Infection (UTI) and Kidney Stone in the Nalbari, Sonitpur and Tinsukia Districts of Assam, India","authors":"Akib Ali, Debashish Khanikar, Bidisha Kataki","doi":"10.47552/ijam.v14i3.3568","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3568","url":null,"abstract":"Natural products derived from plants have essential biological parts in contradiction of many pathogenic organisms and are considered a principal source of modern synthetic drugs. A thorough field survey of ethnomedicinal plants was conducted between the months of July, 2022 to December, 2022 in three districts of Assam, namely Nalbari, Sonitpur and Tinsukia. Indigenous knowledge of the traditional medicines used for Urinary Tract Infection (UTI), Urinary Tract stones or kidney stones were gathered based on personal interviews and questionnaires. Medicinal plants with their family, local names, parts used and target diseases were documented. A total of 51 species were documented; of which, amaranthaceae family showed the highest number of species (6), followed by malvaceae (4), fabaceae (3), euphorbiaceae (3), asteraceae (3) etc. This survey revealed several effective medicinal plants that have significant pharmacogenetic properties, especially for UTI and kidney diseases.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135788426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3893
Sreedevi V P, Rajeshwari V Kamat
Background
The Shirashulahara lepa is used in folklore medicine practised as preventive and curative healthcare need in Kerala. The present study was aimed to validate the traditional medicinal knowledge through pharmacognostical standardization. Aim and objective: The objective is to create a Non-codified formulation called Shirashulahara lepa using two different approaches, and then analyze its properties and composition. Methods:The preparation methods of Shirashulahara lepa differ based on the base ingredient used. The first method involves utilizing Narikela taila (Coconut oil) while the second method involves the use of Beeswax. The Preparation of medicine has been carried out and the Physico-chemical parameters of finished lepa such as pH, Spreadability, Rancidity etc were performed as per API guidelines. Obseravtion: Detailed TLC fingerprint profile of methanolic extracts of the formulation and GC-MS of the selected Method has also been performed. Further in-vivo and clinical studies are also suggested. Result: The results obtained from the first method employing Narikela taila were superior.
{"title":"Characterisation of Shirashulahara Lepa – A Non-Codified Formulation","authors":"Sreedevi V P, Rajeshwari V Kamat","doi":"10.47552/ijam.v14i3.3893","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3893","url":null,"abstract":"Background
 The Shirashulahara lepa is used in folklore medicine practised as preventive and curative healthcare need in Kerala. The present study was aimed to validate the traditional medicinal knowledge through pharmacognostical standardization. Aim and objective: The objective is to create a Non-codified formulation called Shirashulahara lepa using two different approaches, and then analyze its properties and composition. Methods:The preparation methods of Shirashulahara lepa differ based on the base ingredient used. The first method involves utilizing Narikela taila (Coconut oil) while the second method involves the use of Beeswax. The Preparation of medicine has been carried out and the Physico-chemical parameters of finished lepa such as pH, Spreadability, Rancidity etc were performed as per API guidelines. Obseravtion: Detailed TLC fingerprint profile of methanolic extracts of the formulation and GC-MS of the selected Method has also been performed. Further in-vivo and clinical studies are also suggested. Result: The results obtained from the first method employing Narikela taila were superior.
","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3958
Priyanka A Dorage, Ashish A Thatere
Introduction: Post COVID-19 Syndrome is term given to multitudinous health impacts that persist more than four weeks after being infected with SARS CoV-2. Viral infections are one of the causative factors which lead to infertility by affecting the hypothalamic–pituitary–adrenal, gonad axes. Covid-19 can be corelated with Janapadodhwansajanya Vyadhi and Abhishangaja Jvara while Post COVID-19 can be corelated with Jeerna Abhishangaja Jvara. Methodology: Information for present review is compiled from classical texts of Ayurved with commentary and variety of scientific search databases including Google Scholar, NCBI, PubMed and Science Direct by using keywords like Post COVID-19 infertility, Ayurved and Post COVID-19 infertility etc. Articles studied in detail after screening for relevancy to synthesize qualitative review. Result: The result reviewed on semen analysis, Renin angiotensin system, sperm DNA and morphology, cytokine storm, oxidative and mental stress. This review also illustrates the reproductive organ histology related to inflammatory responses, receptors like ACE-2, TMPRSS2 etc., various cases reported like orchitis, irregular menstruation, premature birth, caesarean delivery etc. due to SARSCOV-2 exposure. This showed association between Long COVID and infertility. Discussion: Information discussed are focused on various study conducted on impact of COVID crisis related to various infertility parameters associated with Long COVID. Due to Jirna Avastha of Jvara (~Fever persists after 21 days from onset), Uttarottar Sapta Dhatu Dushti occurs which ultimately can land up in Dushti of Shukra Dhatu, Shukravaha Strotas and Aartavavaha Strotas (~Reproductive system). The integrative approach of Ayurvedic management will be beneficial in such cases.
{"title":"Integrative Approach on Post COVID-19 and Infertility: A Literature Review","authors":"Priyanka A Dorage, Ashish A Thatere","doi":"10.47552/ijam.v14i3.3958","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3958","url":null,"abstract":"Introduction: Post COVID-19 Syndrome is term given to multitudinous health impacts that persist more than four weeks after being infected with SARS CoV-2. Viral infections are one of the causative factors which lead to infertility by affecting the hypothalamic–pituitary–adrenal, gonad axes. Covid-19 can be corelated with Janapadodhwansajanya Vyadhi and Abhishangaja Jvara while Post COVID-19 can be corelated with Jeerna Abhishangaja Jvara. Methodology: Information for present review is compiled from classical texts of Ayurved with commentary and variety of scientific search databases including Google Scholar, NCBI, PubMed and Science Direct by using keywords like Post COVID-19 infertility, Ayurved and Post COVID-19 infertility etc. Articles studied in detail after screening for relevancy to synthesize qualitative review. Result: The result reviewed on semen analysis, Renin angiotensin system, sperm DNA and morphology, cytokine storm, oxidative and mental stress. This review also illustrates the reproductive organ histology related to inflammatory responses, receptors like ACE-2, TMPRSS2 etc., various cases reported like orchitis, irregular menstruation, premature birth, caesarean delivery etc. due to SARSCOV-2 exposure. This showed association between Long COVID and infertility. Discussion: Information discussed are focused on various study conducted on impact of COVID crisis related to various infertility parameters associated with Long COVID. Due to Jirna Avastha of Jvara (~Fever persists after 21 days from onset), Uttarottar Sapta Dhatu Dushti occurs which ultimately can land up in Dushti of Shukra Dhatu, Shukravaha Strotas and Aartavavaha Strotas (~Reproductive system). The integrative approach of Ayurvedic management will be beneficial in such cases.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-03DOI: 10.47552/ijam.v14i3.3824
Dash G, Dinesh Patil, Mahesh M Parappagoudra, Anjali G
Avascular necrosis (AVN) of the bone is a condition characterized by the death or necrosis of bone tissue, accompanied by structural changes. It is also referred to as osteonecrosis or ischemic necrosis of the bone. It is mostly seen in patients having a history of excessive alcohol and high-dose steroid medications. In the initial stage, it is painless but as the disease progresses there is a gradual increase in pain which affects the patient’s daily routine as well as his lifestyle. It is the most challenging condition in orthopedics. The available treatments in modern medicine for this condition are not considered satisfactory in the current era. Here we present a case of Avascular Necrosis (AVN) of the Femoral Head that was treated with Panchakarma procedures, including Udvartana, Abhyanga, Swedana, Basti karma, Raktamokshana, and Physiotherapy exercise. In Ayurveda, AVN Head of Femur can be co-related to Asthi Majjagata Vata, based on similar signs and symptoms. Marked improvements were observed in terms of pain reduction, range of motion, and overall quality of life. The study shows that Avascular Necrosis of the Femoral head may be successfully managed with Panchakarma treatment, Shaman chikitsa, and Physiotherapy Exercises.
{"title":"Ayurvedic management of Asthimajja gata vata w.s.r to AVN of head of femur – A case study","authors":"Dash G, Dinesh Patil, Mahesh M Parappagoudra, Anjali G","doi":"10.47552/ijam.v14i3.3824","DOIUrl":"https://doi.org/10.47552/ijam.v14i3.3824","url":null,"abstract":"Avascular necrosis (AVN) of the bone is a condition characterized by the death or necrosis of bone tissue, accompanied by structural changes. It is also referred to as osteonecrosis or ischemic necrosis of the bone. It is mostly seen in patients having a history of excessive alcohol and high-dose steroid medications. In the initial stage, it is painless but as the disease progresses there is a gradual increase in pain which affects the patient’s daily routine as well as his lifestyle. It is the most challenging condition in orthopedics. The available treatments in modern medicine for this condition are not considered satisfactory in the current era. Here we present a case of Avascular Necrosis (AVN) of the Femoral Head that was treated with Panchakarma procedures, including Udvartana, Abhyanga, Swedana, Basti karma, Raktamokshana, and Physiotherapy exercise. In Ayurveda, AVN Head of Femur can be co-related to Asthi Majjagata Vata, based on similar signs and symptoms. Marked improvements were observed in terms of pain reduction, range of motion, and overall quality of life. The study shows that Avascular Necrosis of the Femoral head may be successfully managed with Panchakarma treatment, Shaman chikitsa, and Physiotherapy Exercises.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135789513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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