Pub Date : 2021-11-18DOI: 10.18203/2319-2003.ijbcp20214474
P. Manjhi, S. Singh, C. Kumar, Akhilesh Kumar Rana
Background: Antitussive-expectorants are among the most frequently prescribed drugs by physicians in clinical practice. Upper respiratory tract infections, such as common cold, acute pharyngitis and acute trachea-bronchitis, are the most common of all communicable diseases and significantly increase OPD burden. This study aimed to assess the rational use, cost ratio, and percentage cost variations in different brands of the commonly prescribed antitussive-expectorants available in the Indian market.Methods: The cost of antitussive-expectorant manufactured by different pharmaceutical companies was obtained by using drug today Jan-April 2021 vol 2. The maximum and minimum price was noted down, cost ratio and percentage cost variation of the individual formulation were analysed. Results: Analysis of cost ratio and percentage cost variation for each formulation of the antitussive-expectorants drug, syrup (100 ml) chlorpheniramine (2 mg), dextromethorphan (10 mg), phenylephrine (5 mg) combinations show the highest cost ratio and percentage cost variation as 5.30 and 430.25 respectively, and syrup (100 ml) dextromethorphan (10 mg), guaifenesin (100 mg), phenylephrine (25 mg), chlorpheniramine (4 mg) combinations show lowest cost ratio and percentage cost variation as 1.17 and 17.69 respectively.Conclusions: There was a wide variation in the cost of different brands of antitussive-expectorant drugs available in the Indian market. So, clinicians should be aware of rational use and variations in cost to reduce the treatment cost and increase patient compliance.
{"title":"Rational use and cost variation analysis of antitussive-expectorants available in the Indian market: a pharmacoeconomic study","authors":"P. Manjhi, S. Singh, C. Kumar, Akhilesh Kumar Rana","doi":"10.18203/2319-2003.ijbcp20214474","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214474","url":null,"abstract":"Background: Antitussive-expectorants are among the most frequently prescribed drugs by physicians in clinical practice. Upper respiratory tract infections, such as common cold, acute pharyngitis and acute trachea-bronchitis, are the most common of all communicable diseases and significantly increase OPD burden. This study aimed to assess the rational use, cost ratio, and percentage cost variations in different brands of the commonly prescribed antitussive-expectorants available in the Indian market.Methods: The cost of antitussive-expectorant manufactured by different pharmaceutical companies was obtained by using drug today Jan-April 2021 vol 2. The maximum and minimum price was noted down, cost ratio and percentage cost variation of the individual formulation were analysed. Results: Analysis of cost ratio and percentage cost variation for each formulation of the antitussive-expectorants drug, syrup (100 ml) chlorpheniramine (2 mg), dextromethorphan (10 mg), phenylephrine (5 mg) combinations show the highest cost ratio and percentage cost variation as 5.30 and 430.25 respectively, and syrup (100 ml) dextromethorphan (10 mg), guaifenesin (100 mg), phenylephrine (25 mg), chlorpheniramine (4 mg) combinations show lowest cost ratio and percentage cost variation as 1.17 and 17.69 respectively.Conclusions: There was a wide variation in the cost of different brands of antitussive-expectorant drugs available in the Indian market. So, clinicians should be aware of rational use and variations in cost to reduce the treatment cost and increase patient compliance.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80059745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-13DOI: 10.18203/2319-2003.ijbcp20214449
Hemali Savla, Isha Naik, Chandrashekhar Gargote, Nischal Shashidhar, Sneha G. Nair, M. Menon
Background: Alginate-based, raft-forming antacid products with reflux suppressant activity are complex formulations expected to achieve effective raft formation and cause elimination or displacement of the acid pocket, which is typically manifested in gastroesophageal reflux disease (GERD).Methods: In the present study, six alginate-based raft-forming products commercially available in the Indian market were compared in terms of their acid neutralization properties, strength, resilience and structural and thermal properties of their rafts. Percent alginate content was also determined.Results: Rafts of products containing calcium-based antacids formed voluminous, porous and floating rafts within seconds of addition to the simulated gastric fluid (SGF) compared with the products that contained aluminium and magnesium-based antacids. Marked differences were not evident in the ANC (acid neutralization capacity) values of the various products. No correlation was observed between ANC and raft-forming capacity or duration of neutralization. Raft structures affected their neutralization profiles. Rafts of porous and absorbent nature could retain their ANC probably due to release of trapped antacids. Further, raft strengths of only two products were above the British Pharmacopoeia specification of not less than 7.5 g. Sodium alginate content was within specifications (85-115%) for three of the six products.Conclusions: Raft-forming formulations with higher alginate content and calcium-based antacids have better physicochemical properties such as ANC, neutralization profiles, raft strength and raft resilience than those with lower alginate content or those containing aluminium or magnesium-based antacids.
{"title":"Physicochemical properties of various alginate-based raft-forming antacid products: a comparative study","authors":"Hemali Savla, Isha Naik, Chandrashekhar Gargote, Nischal Shashidhar, Sneha G. Nair, M. Menon","doi":"10.18203/2319-2003.ijbcp20214449","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214449","url":null,"abstract":"Background: Alginate-based, raft-forming antacid products with reflux suppressant activity are complex formulations expected to achieve effective raft formation and cause elimination or displacement of the acid pocket, which is typically manifested in gastroesophageal reflux disease (GERD).Methods: In the present study, six alginate-based raft-forming products commercially available in the Indian market were compared in terms of their acid neutralization properties, strength, resilience and structural and thermal properties of their rafts. Percent alginate content was also determined.Results: Rafts of products containing calcium-based antacids formed voluminous, porous and floating rafts within seconds of addition to the simulated gastric fluid (SGF) compared with the products that contained aluminium and magnesium-based antacids. Marked differences were not evident in the ANC (acid neutralization capacity) values of the various products. No correlation was observed between ANC and raft-forming capacity or duration of neutralization. Raft structures affected their neutralization profiles. Rafts of porous and absorbent nature could retain their ANC probably due to release of trapped antacids. Further, raft strengths of only two products were above the British Pharmacopoeia specification of not less than 7.5 g. Sodium alginate content was within specifications (85-115%) for three of the six products.Conclusions: Raft-forming formulations with higher alginate content and calcium-based antacids have better physicochemical properties such as ANC, neutralization profiles, raft strength and raft resilience than those with lower alginate content or those containing aluminium or magnesium-based antacids.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74129012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214119
M. P., A. S., S. K, G. G, R. K.
Background: Drug utilization plays a key role in helping the healthcare system to understand, interpret and improve the prescribing, administration and use of medications. The objective of the study was to assess the drug utilization pattern of drugs prescribed in conservative management of pancreatitis patients in a tertiary care teaching hospital.Methods: This prospective observational study was conducted in department of surgery, Rajah Muthiah Medical College and Hospital, Annamalai University. The study period was six months from November 2019 to April 2020. A total of 115 patients were selected based on inclusion and exclusion criteria.Results: The study population containing of 90% (n=104) males and 10% (n=11) females were included in the study. Most of the patients between age group of 25-44 years (48%). The most common etiology was alcoholic 68% (n=78). 7% of population with comorbidities (5% hypertension, 2% diabetes mellitus). In analgesics, tramadol (28%) and in antibiotics cefotaxime 21% was most prescribed. Lactated ringer solution (36%) was prescribed most as intravenous hydration. 7% (n=8) and 3% (n=4) of patients receiving enteral nutrition and parenteral nutrition. The average number of drugs per prescription was 8.5. Out of 1205 drugs, 61% of drugs prescribed in generic form, 39% were prescribed in brand name. The study analyzed that 69% of drugs were prescribed from essential drugs list (EDL) 2019 and 84% drugs prescribed from national list of essential medicines (NLEM) 2015. Number of prescriptions with injection were 79.07%. The overall antibiotic encounter rate 15%. Prescribed daily dose/defined daily dose (PDD/DDD) ratio of folic acid was 5.Conclusions: Drug utilization study can help in evaluating the quality of care given to the pancreatitis patients and promote rational use of medicines.
{"title":"Study on drug utilization pattern in conservative management of patients with pancreatitis in a tertiary care teaching hospital","authors":"M. P., A. S., S. K, G. G, R. K.","doi":"10.18203/2319-2003.ijbcp20214119","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214119","url":null,"abstract":"Background: Drug utilization plays a key role in helping the healthcare system to understand, interpret and improve the prescribing, administration and use of medications. The objective of the study was to assess the drug utilization pattern of drugs prescribed in conservative management of pancreatitis patients in a tertiary care teaching hospital.Methods: This prospective observational study was conducted in department of surgery, Rajah Muthiah Medical College and Hospital, Annamalai University. The study period was six months from November 2019 to April 2020. A total of 115 patients were selected based on inclusion and exclusion criteria.Results: The study population containing of 90% (n=104) males and 10% (n=11) females were included in the study. Most of the patients between age group of 25-44 years (48%). The most common etiology was alcoholic 68% (n=78). 7% of population with comorbidities (5% hypertension, 2% diabetes mellitus). In analgesics, tramadol (28%) and in antibiotics cefotaxime 21% was most prescribed. Lactated ringer solution (36%) was prescribed most as intravenous hydration. 7% (n=8) and 3% (n=4) of patients receiving enteral nutrition and parenteral nutrition. The average number of drugs per prescription was 8.5. Out of 1205 drugs, 61% of drugs prescribed in generic form, 39% were prescribed in brand name. The study analyzed that 69% of drugs were prescribed from essential drugs list (EDL) 2019 and 84% drugs prescribed from national list of essential medicines (NLEM) 2015. Number of prescriptions with injection were 79.07%. The overall antibiotic encounter rate 15%. Prescribed daily dose/defined daily dose (PDD/DDD) ratio of folic acid was 5.Conclusions: Drug utilization study can help in evaluating the quality of care given to the pancreatitis patients and promote rational use of medicines.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77605239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214120
Soumitra Mandal, Aruna Donepudi, Jabeen Afshan, S. Turaga
Background: Epilepsy is a disorder characterized by repeated seizures due to the disorder of the neurons. Epilepsy needs life-long medical therapy. It is managed by polytherapy. Drug utilization studies help to determine rational combinations of drug use in epilepsy. Aims and objectives of the study were to analyses the drug utilization pattern of anti-epileptics and common types of epileptic seizures and to determine the safety of antiepileptic drugs (AEDs).Methods: It was a prospective, cross-sectional, observational study. Patients attending neurology epilepsy OPD with h/o seizures and taking at least one antiepileptic were recruited. Data was collected by taking demographic details including brief history of disease, clinical examination and reviewing OPD prescription. Details were recorded in case record form.Results: We recruited 102 participants (57 male and 45 females) of mean age 29.68±10.52. Mean age of onset of epilepsy was 18.9±10.5 years. Among them 77 (75.4%) were diagnosed as generalized tonic clonic seizures and 18 (17.6%) were diagnosed as focal seizures. Monotherapy was given in 31 (30.3%) patients while polytherapy was given in 71 (69.7%) patients. Valproic acid was most commonly used monotherapy (12 patients). No fixed drug combinations were used. Clobazam in 55 (53.9%) patients and valproic acid in 53 (51.9%) patients were prescribed. The other AEDs prescribed were lamotrigine, oxcarbazepine, carbamazepine, lacosamide, zincosamide, perampanel, and phenytoin. All antiepileptics were prescribed in brand name. The prescribed daily dose (PDD) was less than defined daily dose (DDD) as per anatomical therapeutic chemical (ATC) classification. Two adverse effects were reported during study period. They were mood change and blurring of vision in two different patients.Conclusions: The PDD was less than DDD as per ATC classification. Awareness should be created among neurologists to prescribe more generic drugs because of their cost effectiveness. Studies are needed with larger sample size to analyze the drug utilization patterns which helps in the planning of reduction of expenditure for the patient without compromising efficacy.
{"title":"A drug utilization study of antiepileptic drugs uses in a tertiary care teaching hospital of India","authors":"Soumitra Mandal, Aruna Donepudi, Jabeen Afshan, S. Turaga","doi":"10.18203/2319-2003.ijbcp20214120","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214120","url":null,"abstract":"Background: Epilepsy is a disorder characterized by repeated seizures due to the disorder of the neurons. Epilepsy needs life-long medical therapy. It is managed by polytherapy. Drug utilization studies help to determine rational combinations of drug use in epilepsy. Aims and objectives of the study were to analyses the drug utilization pattern of anti-epileptics and common types of epileptic seizures and to determine the safety of antiepileptic drugs (AEDs).Methods: It was a prospective, cross-sectional, observational study. Patients attending neurology epilepsy OPD with h/o seizures and taking at least one antiepileptic were recruited. Data was collected by taking demographic details including brief history of disease, clinical examination and reviewing OPD prescription. Details were recorded in case record form.Results: We recruited 102 participants (57 male and 45 females) of mean age 29.68±10.52. Mean age of onset of epilepsy was 18.9±10.5 years. Among them 77 (75.4%) were diagnosed as generalized tonic clonic seizures and 18 (17.6%) were diagnosed as focal seizures. Monotherapy was given in 31 (30.3%) patients while polytherapy was given in 71 (69.7%) patients. Valproic acid was most commonly used monotherapy (12 patients). No fixed drug combinations were used. Clobazam in 55 (53.9%) patients and valproic acid in 53 (51.9%) patients were prescribed. The other AEDs prescribed were lamotrigine, oxcarbazepine, carbamazepine, lacosamide, zincosamide, perampanel, and phenytoin. All antiepileptics were prescribed in brand name. The prescribed daily dose (PDD) was less than defined daily dose (DDD) as per anatomical therapeutic chemical (ATC) classification. Two adverse effects were reported during study period. They were mood change and blurring of vision in two different patients.Conclusions: The PDD was less than DDD as per ATC classification. Awareness should be created among neurologists to prescribe more generic drugs because of their cost effectiveness. Studies are needed with larger sample size to analyze the drug utilization patterns which helps in the planning of reduction of expenditure for the patient without compromising efficacy.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78323108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214115
Ketas Mahajan, Sneh Dudhia
Background: Increased prevalence as well as burden affecting osteoarthritis of knee joint has led to increase in concerns regarding safety of various pharmacological methods. Hence, there is an increase in demand for newer and effective strategies for treatment and management. Thus, a novel alternate for treatment is required that might repair damage to cartilage rather than simply reduce related symptoms. The aim of this study was to study the efficacy of intra-articular methylprednisolone along with platelet rich plasma versus platelet rich plasma in early knee osteoarthritis. Methods: This retrospective study was conducted on 60 patients diagnosed with initial stages of osteoarthritis of knee according to Kellgren-Lawrence classification. Patients age range was between 40 to 80 years who were divided into 2 groups; group I: It contained 30 subjects treated with intra-articular injections of Platelet Rich Plasma in combination with methylprednisolone and group II: comprised of 30 patients treated with intra-articular injection of Platelet rich Plasma alone. Clinical data pertaining to medical history, VAS and KOOS scores were collected. Statistical analysis was performed using the student’s t test. Results: Statistically significant improvements in VAS and KOOS score values were observed on assessment of scores at baseline, 1, 3 and 6 months intervals, respectively. Conclusions: It can be concluded from the study that a combination therapy of intra-articular injection of combination of PRP with methylprednisolone yields superior results when compared to use of PRP injections alone.
{"title":"Efficacy of intra-articular methylprednisolone along with platelet rich plasma vs. platelet rich plasma in early osteoarthritis: a retrospective study","authors":"Ketas Mahajan, Sneh Dudhia","doi":"10.18203/2319-2003.ijbcp20214115","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214115","url":null,"abstract":"Background: Increased prevalence as well as burden affecting osteoarthritis of knee joint has led to increase in concerns regarding safety of various pharmacological methods. Hence, there is an increase in demand for newer and effective strategies for treatment and management. Thus, a novel alternate for treatment is required that might repair damage to cartilage rather than simply reduce related symptoms. The aim of this study was to study the efficacy of intra-articular methylprednisolone along with platelet rich plasma versus platelet rich plasma in early knee osteoarthritis. Methods: This retrospective study was conducted on 60 patients diagnosed with initial stages of osteoarthritis of knee according to Kellgren-Lawrence classification. Patients age range was between 40 to 80 years who were divided into 2 groups; group I: It contained 30 subjects treated with intra-articular injections of Platelet Rich Plasma in combination with methylprednisolone and group II: comprised of 30 patients treated with intra-articular injection of Platelet rich Plasma alone. Clinical data pertaining to medical history, VAS and KOOS scores were collected. Statistical analysis was performed using the student’s t test. Results: Statistically significant improvements in VAS and KOOS score values were observed on assessment of scores at baseline, 1, 3 and 6 months intervals, respectively. Conclusions: It can be concluded from the study that a combination therapy of intra-articular injection of combination of PRP with methylprednisolone yields superior results when compared to use of PRP injections alone.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88685753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214114
Ashika Arka Gopalakrishna, N. Bose, S. Stanly
Background: The current study aimed to find out the percentage cost variation among the various brands of statins marketed in India. Statins are HMG-CoA reductase inhibitors which are widely prescribed as blood cholesterol lowering agents and hence reduce illness and mortality in those who are at high risk of cardiovascular disease. There are numerous brands of statins are marketed in India.Methods: Cost of a particular drug manufactured by different companies in the same strength and the dosage form was obtained from the price list provided by the pharmaceutical companies in current index of medical specialities (CIMS) (42nd year January to April 2021). The difference in the maximum and the minimum price of the same drug manufactured by different pharmaceutical companies, cost ratio and the percentage variation in price were analysed.Results: The percentage cost variation of statins was seen highest with tablet atorvastatin 20 mg (564.06%), followed by combination of capsule atorvastatin 10 mg+aspirin 75 mg (325%) which was followed by combination of film coated tablet atorvastatin 10 mg+fenofibrate 160 mg (267.4%), tablet rosuvastatin 20 mg (171.1%), tablet lovastatin 10 mg (108.9%), combination of tablet rosuvastatin 10 mg+fenofibrate 160 mg (87.34%) and lowest was seen with tablet simvastatin 20 mg (6.0%).Conclusions: There is a very wide cost variation among different brands of statins marketed in India. The percentage cost variation was found to be the highest among the moderate intensity statins.
{"title":"Cost variation analysis of statins available in India","authors":"Ashika Arka Gopalakrishna, N. Bose, S. Stanly","doi":"10.18203/2319-2003.ijbcp20214114","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214114","url":null,"abstract":"Background: The current study aimed to find out the percentage cost variation among the various brands of statins marketed in India. Statins are HMG-CoA reductase inhibitors which are widely prescribed as blood cholesterol lowering agents and hence reduce illness and mortality in those who are at high risk of cardiovascular disease. There are numerous brands of statins are marketed in India.Methods: Cost of a particular drug manufactured by different companies in the same strength and the dosage form was obtained from the price list provided by the pharmaceutical companies in current index of medical specialities (CIMS) (42nd year January to April 2021). The difference in the maximum and the minimum price of the same drug manufactured by different pharmaceutical companies, cost ratio and the percentage variation in price were analysed.Results: The percentage cost variation of statins was seen highest with tablet atorvastatin 20 mg (564.06%), followed by combination of capsule atorvastatin 10 mg+aspirin 75 mg (325%) which was followed by combination of film coated tablet atorvastatin 10 mg+fenofibrate 160 mg (267.4%), tablet rosuvastatin 20 mg (171.1%), tablet lovastatin 10 mg (108.9%), combination of tablet rosuvastatin 10 mg+fenofibrate 160 mg (87.34%) and lowest was seen with tablet simvastatin 20 mg (6.0%).Conclusions: There is a very wide cost variation among different brands of statins marketed in India. The percentage cost variation was found to be the highest among the moderate intensity statins. ","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89851582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214113
A. Eduviere, P. E. Awhin, K. E. Edje, L. Otomewo, E. G. Moke, A. Omogbiya, Oghenemaro P. Idiowa
Background: Sleep deprivation has often been implicated in several neurological disorders. Centella lujica is a psychoactive herb with medically-beneficial therapeutic potential. The current study sought to evaluate the neuroprotective effect of Centella lujica supplement in experimental animals.Methods: Sleep deprivation in mice was done using the multiple platforms over water model.Results: Upon treatment with Centella lujica supplement, the parameters of anxiety-like behaviour induced by sleep deprivation were found to be significantly diminished in comparison to the sleep deprived animals.Conclusions: Centella lujica treatment significantly decreased hyper locomotion, and anxiety-like behaviour caused by sleep deprivation.
{"title":"Pharmacological investigations of neuroprotective potential of Centella lujica supplement on sleep deprivation-induced anxiety-like behaviour in mice","authors":"A. Eduviere, P. E. Awhin, K. E. Edje, L. Otomewo, E. G. Moke, A. Omogbiya, Oghenemaro P. Idiowa","doi":"10.18203/2319-2003.ijbcp20214113","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214113","url":null,"abstract":"Background: Sleep deprivation has often been implicated in several neurological disorders. Centella lujica is a psychoactive herb with medically-beneficial therapeutic potential. The current study sought to evaluate the neuroprotective effect of Centella lujica supplement in experimental animals.Methods: Sleep deprivation in mice was done using the multiple platforms over water model.Results: Upon treatment with Centella lujica supplement, the parameters of anxiety-like behaviour induced by sleep deprivation were found to be significantly diminished in comparison to the sleep deprived animals.Conclusions: Centella lujica treatment significantly decreased hyper locomotion, and anxiety-like behaviour caused by sleep deprivation.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81322654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214124
S. Varthya, H. Krishna
Medical devices have gained popularity as a therapeutic or diagnostic purpose in gastrointestinal obstructions caused by malignant tumour or benign stricture or any other pre-existing conditions. The problems of stents are like sense of foreign body, migration or incomplete expansion or re obstruction. In this scenarios, self-expandable metallic stents (SEMS), or biodegradable self-expanding stents, wall flex stents, drug eluted stents, etc prevents the obstruction related difficulties. SEMS associated with re-obstruction and migration along with difficulty in removal and chances of leaks due to corrosion. In case of biodegradable self-expanding stents, which are either made of magnesium-based materials or synthetic polymers, such as polylactide or polyglycolide, or co-polymers, such as polydioxanone. Magnesium-based materials are very biocompatible but due to the property of dissolving in the body by rapid corrosion, degradation can occur before the therapeutic objective is reached. Synthetic polymers associated severe mucosal hyperplastic reaction with overgrowth and/or ingrowth. Wall flex stents, drug eluted stents can be used to prevent complications associated with above variants but their clinical significance and toxicological effects were not evaluated completely. Under this given scenario toxicological evolution of various medical devices used in gastrointestinal disease and their potential toxicological effects are required to understand their tolerability and acceptability.
{"title":"Chemical characterization, adverse effects and potential toxicological effects of medical devices applied in gastrointestinal disease: a review","authors":"S. Varthya, H. Krishna","doi":"10.18203/2319-2003.ijbcp20214124","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214124","url":null,"abstract":"Medical devices have gained popularity as a therapeutic or diagnostic purpose in gastrointestinal obstructions caused by malignant tumour or benign stricture or any other pre-existing conditions. The problems of stents are like sense of foreign body, migration or incomplete expansion or re obstruction. In this scenarios, self-expandable metallic stents (SEMS), or biodegradable self-expanding stents, wall flex stents, drug eluted stents, etc prevents the obstruction related difficulties. SEMS associated with re-obstruction and migration along with difficulty in removal and chances of leaks due to corrosion. In case of biodegradable self-expanding stents, which are either made of magnesium-based materials or synthetic polymers, such as polylactide or polyglycolide, or co-polymers, such as polydioxanone. Magnesium-based materials are very biocompatible but due to the property of dissolving in the body by rapid corrosion, degradation can occur before the therapeutic objective is reached. Synthetic polymers associated severe mucosal hyperplastic reaction with overgrowth and/or ingrowth. Wall flex stents, drug eluted stents can be used to prevent complications associated with above variants but their clinical significance and toxicological effects were not evaluated completely. Under this given scenario toxicological evolution of various medical devices used in gastrointestinal disease and their potential toxicological effects are required to understand their tolerability and acceptability.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86635262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214117
Latha Kamath, Nishith R. S., A. Chakraborty
Background: COVID-19 pandemic shifted all the classroom teaching to virtual online platforms. The overnight change in the teaching structure posed serious challenges especially for medical education. This study aims to assess the well-being of medical students undergoing online medical education during COVID-19 pandemic and their perspective on online pharmacology classes.Methods: World health organization (WHO-5) well-being index was used to assess well-being of students. An internally validated questionnaire was used to assess student’s perspective on online pharmacology classes. The questionnaire was administered to eligible consenting students online through Google forms. The data obtained was analysed by SPSS software.Results: The mean wellness score (%) for all participants, (n=118) was 48.87%. The mean wellness score for males (58.67%) was higher than for females (42.41%). The average score for overall benefit of conducting online pharmacology classes was 3.32 out of 5. Objectively assessed online interactions like formative assessment, polls and quiz were rated higher than subjective interactions like debate.Conclusions: COVID-19 pandemic has caused massive disruption in the life of many people. In our study, we report a decreased well-being score in medical students attending virtual classes. The findings on well-being of students have implications on planning redressal mechanism in such extreme situations. Our analysis of student’s perspective about online interactions has implications beyond online classes. Some of the interactions can be instituted into regular curriculum increasing the student’s participation.
{"title":"Well-being and perspective of second year MBBS students on online pharmacology classes held during COVID-19 pandemic in a tertiary care teaching hospital","authors":"Latha Kamath, Nishith R. S., A. Chakraborty","doi":"10.18203/2319-2003.ijbcp20214117","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214117","url":null,"abstract":"Background: COVID-19 pandemic shifted all the classroom teaching to virtual online platforms. The overnight change in the teaching structure posed serious challenges especially for medical education. This study aims to assess the well-being of medical students undergoing online medical education during COVID-19 pandemic and their perspective on online pharmacology classes.Methods: World health organization (WHO-5) well-being index was used to assess well-being of students. An internally validated questionnaire was used to assess student’s perspective on online pharmacology classes. The questionnaire was administered to eligible consenting students online through Google forms. The data obtained was analysed by SPSS software.Results: The mean wellness score (%) for all participants, (n=118) was 48.87%. The mean wellness score for males (58.67%) was higher than for females (42.41%). The average score for overall benefit of conducting online pharmacology classes was 3.32 out of 5. Objectively assessed online interactions like formative assessment, polls and quiz were rated higher than subjective interactions like debate.Conclusions: COVID-19 pandemic has caused massive disruption in the life of many people. In our study, we report a decreased well-being score in medical students attending virtual classes. The findings on well-being of students have implications on planning redressal mechanism in such extreme situations. Our analysis of student’s perspective about online interactions has implications beyond online classes. Some of the interactions can be instituted into regular curriculum increasing the student’s participation.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80349713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-22DOI: 10.18203/2319-2003.ijbcp20214121
P. Mishra, V. Verma, Meenakshi Meenu, A. Mohan, J. Bhatia, D. Arya
Background: Monitoring of anti-tubercular therapy (ATT) response necessary for successful completion of ATT regimen. Presently available monitoring tools are invasive and have limitations. This study undertaken to see whether non-invasive tools like body mass index (BMI), hand grip strength (HGS) and quality of life (QOL) can serve as a reliable tool for monitoring ATT response.Methods: The 50 patients of tuberculosis were monitored for BMI, HGS and QOL via WHOQOL-BREF questionnaire and analyzed at baseline, 2 months and 6 months of starting ATT.Results: BMI HGS increased significantly at 2 months and 6 months compared to baseline with ATT. Physical and social domain of WHOQOL-BREF increased at 2 and 6 months with ATT, other domains shown no significant changes.Conclusions: Monitoring of BMI, handgrip strength and QOL can be a cost-effective tool for monitoring ATT response, both in pulmonary and extra pulmonary tuberculosis.
{"title":"Association of body mass index, hand grip strength and quality of life with response to anti-tubercular therapy in adult patients of pulmonary and extra-pulmonary tuberculosis","authors":"P. Mishra, V. Verma, Meenakshi Meenu, A. Mohan, J. Bhatia, D. Arya","doi":"10.18203/2319-2003.ijbcp20214121","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20214121","url":null,"abstract":"Background: Monitoring of anti-tubercular therapy (ATT) response necessary for successful completion of ATT regimen. Presently available monitoring tools are invasive and have limitations. This study undertaken to see whether non-invasive tools like body mass index (BMI), hand grip strength (HGS) and quality of life (QOL) can serve as a reliable tool for monitoring ATT response.Methods: The 50 patients of tuberculosis were monitored for BMI, HGS and QOL via WHOQOL-BREF questionnaire and analyzed at baseline, 2 months and 6 months of starting ATT.Results: BMI HGS increased significantly at 2 months and 6 months compared to baseline with ATT. Physical and social domain of WHOQOL-BREF increased at 2 and 6 months with ATT, other domains shown no significant changes.Conclusions: Monitoring of BMI, handgrip strength and QOL can be a cost-effective tool for monitoring ATT response, both in pulmonary and extra pulmonary tuberculosis.","PeriodicalId":13901,"journal":{"name":"International Journal of Basic & Clinical Pharmacology","volume":"18 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91405197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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