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International Journal of Celiac Disease最新文献

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Any Time Laparoscopic Cholecystectomy in Moderate to Severe Acute Cholecystitis without Septic Shock 无感染性休克的中重度急性胆囊炎随时腹腔镜胆囊切除术
Pub Date : 2021-11-12 DOI: 10.12691/ijcd-9-3-1
Bhavin B Vasavada, H. Patel
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引用次数: 0
In Memory of Professor Marsh NM: The Researcher who Understood and Lived Celiac Disease 纪念Marsh NM教授:了解并生活在乳糜泻中的研究者
Pub Date : 2021-11-12 DOI: 10.12691/ijcd-9-3-6
A. Lerner
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引用次数: 0
Appreciation of the Quality of Life of Patients with Atopic Dermatitis. Clinical and Laboratory Study 特应性皮炎患者生活质量的评价。临床及化验研究
Pub Date : 2021-11-12 DOI: 10.12691/ijcd-9-3-8
E. Duca, M. Pascal, G. Sur, Remus Gaga, L. Sur
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引用次数: 0
More Than Celiac Disease - Five Gluten-induced Pathologies 不仅仅是乳糜泻——五种麸质引起的疾病
Pub Date : 2021-11-12 DOI: 10.12691/ijcd-9-3-7
Maria Lucia Sur, M. Pascal, Remus Gaga
Gluten can induce several conditions. However, a lot of people and even medical practitioners only associate gluten pathology with its most severe form neglecting other pathologies. In addition to this, clinical manifestations of celiac disease are not always classic and for this reason, many cases are diagnosed late, being characterized by intricate symptoms that can be attributed to other conditions. In the present study, we try to bring a systematization of the five major gluten-induced manifestations: celiac disease, non-celiac gluten sensitivity, wheat allergy, gluten ataxia, and dermatitis herpetiformis.
谷蛋白可以诱发几种疾病。然而,很多人,甚至是医生都只把麸质病理学与麸质最严重的形式联系起来,而忽视了其他病理。除此之外,乳糜泻的临床表现并不总是典型的,因此,许多病例诊断较晚,其特征是复杂的症状,这些症状可能归因于其他疾病。在本研究中,我们试图将麸质诱导的五种主要表现系统化:乳糜泻,非乳糜泻麸质敏感,小麦过敏,麸质共济失调和疱疹样皮炎。
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引用次数: 0
Drug-induced Collagenous Sprue: A Reversible Small Bowel Mucosal Disorder 药物诱导的胶原性口疮:一种可逆的小肠黏膜紊乱
Pub Date : 2021-05-18 DOI: 10.12691/IJCD-9-2-6
H. Freeman
Collagenous sprue is an unusual small intestinal mucosal disorder characterized by flattened small intestinal mucosa, unusual sub-epithelial collagen deposits, increased intra-epithelial lymphocytes, often denuded epithelial cells and resistance to therapy, including a gluten-free diet. The disorder is heterogeneous with several potential causes now identified. Similar to sprue-like intestinal disease, collagenous sprue may be caused or precipitated by different pharmaceutical agents. Olmesartan, an angiotensin II inhibitor, often employed in treatment of hypertension, may cause a drug-induced form of sprue-like small intestinal disease with the pathological features of untreated celiac disease refractory to gluten-free diet treatment. In addition, collagenous sprue may be precipitated by olmesartan. Recognition and cessation of the medication has led to resolution of the small intestinal mucosal disorder without steroids or other treatment.
胶原性口疮是一种罕见的小肠黏膜疾病,其特征是小肠黏膜变平,异常的亚上皮胶原沉积,上皮内淋巴细胞增加,上皮细胞经常脱落,对治疗(包括无麸质饮食)有耐药性。这种疾病是异质性的,目前已确定了几种潜在的病因。与芽孢杆菌样肠道疾病类似,胶原芽孢杆菌可由不同的药物制剂引起或沉淀。Olmesartan是一种血管紧张素II抑制剂,常用于治疗高血压,可引起药物诱导的spru样小肠疾病,其病理特征与未经治疗的乳糜泻对无谷蛋白饮食治疗难治相似。此外,奥美沙坦可能会沉淀胶原性口疮。认识和停止用药导致小肠黏膜疾病的解决,无需类固醇或其他治疗。
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引用次数: 0
Antibiotic-Resistant Bacteria in Water and Fish: A Risk to Human Health 水和鱼中的耐抗生素细菌:对人类健康的威胁
Pub Date : 2021-05-18 DOI: 10.12691/IJCD-9-2-2
M. Zaky, S. M. E. Toubar, Ahmed Samy El-Shafey
Water pollution is one of the most severe environmental problems that affect public health and can cause diseases as gastrointestinal diseases. Microbial pollution of Lake Manzala was studied in four main localities, Kapoty, Bashtier, Mataryia and Gamil areas which receive a high load of sewage, agricultural and industrial wastes from different sources. A total of 50 bacterial isolates from water and fish were identified using API 20E system, revealed that 20% of these bacterial strains, were related to Escherichia coli (E. coli), which has been subjected to different antibiotics, such as Ampicillin, Penicillin G, Streptomycin, tetracycline, Gentamycin, Chloramphenicol, rifampicin and Cefotaxime. All strains variation of resistance pattern, harboring Plasmid DNA are an indication of risk to human health in the communities around Manzala Lake, from such bacterial pathogens, which live in polluted and stressed environment.
水污染是影响公众健康的最严重的环境问题之一,可引起胃肠道疾病等疾病。对Manzala湖的微生物污染进行了研究,这些地区分别是Kapoty、Bashtier、Mataryia和Gamil地区,这些地区接收了大量来自不同来源的污水、农业和工业废物。应用API 20E系统对水体和鱼类分离的50株细菌进行了鉴定,结果显示,其中20%的菌株与大肠杆菌(E. coli)有关,该菌株曾受到氨苄西林、青霉素G、链霉素、四环素、庆大霉素、氯霉素、利福平和头孢噻肟等不同抗生素的作用。携带质粒DNA的所有菌株的抗性模式变化表明,这些细菌病原体生活在污染和压力环境中,对Manzala湖周围社区的人类健康构成风险。
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引用次数: 1
An Example to Follow In the COVID-19 Pandemic: Together For Celiac Disease Patients 在COVID-19大流行中遵循的一个例子:共同为乳糜泻患者服务
Pub Date : 2021-05-18 DOI: 10.12691/IJCD-9-2-1
M. O. F. Barriguete
The El Pasoans fighting hunger (EPFH) food bank is a non-profit hunger relief organization that delivers food to partner groups which feed people who are food insecure within the city. The United States Department of Agriculture is the food bank main source of food, other food sources include Feeding America, grocery chains and food donors. While the EPFH food bank has been successful in fulfilling its mission, there has been renewed interest as to if the EPFH food bank takes interest in people with celiac disease by delivering gluten-free foods to them. This article focuses on food delivery with or without gluten, why healthy people order gluten-free products and explains if gluten-free food has beneficial effects on healthy people.
埃尔帕索人抗击饥饿(EPFH)食品银行是一个非营利性的饥饿救济组织,它向伙伴团体提供食物,这些团体为该市粮食不安全的人提供食物。美国农业部是食品银行的主要食品来源,其他食品来源包括“喂养美国”、食品连锁店和食品捐赠者。虽然EPFH食物银行已经成功地完成了它的使命,但人们对EPFH食物银行是否通过向乳糜泻患者提供无麸质食物来关注他们又产生了新的兴趣。这篇文章关注的是有或没有麸质食品的外卖,为什么健康的人会点无麸质食品,并解释了无麸质食品是否对健康的人有益。
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引用次数: 0
Nonresponsive Celiac Disease Treated with a Unique Functional Medical Approach 用独特的功能性医学方法治疗无反应性乳糜泻
Pub Date : 2021-05-18 DOI: 10.12691/IJCD-9-2-7
T. O'bryan, A. Lerner
A 16-year-old boy with nonresponsive celiac disease (NRCD), dermatitis herpetiformis, short stature, and failure to thrive, presented to this Functional Medicine practitioner because he had exceedingly high tissue transglutaminase (tTG) antibodies and poor growth, despite 10 months on a meticulous gluten-free diet (GFD). Immunological testing showed elevated antibody production against multiple peptides of wheat, food antigens, intestinal barrier dysfunction, lipopolysaccharide (LPS) antibodies, and polyreactive autoimmune reactions. An elimination diet, nutraceutical protocols to modulate the microbiome, address intestinal permeability, lower inflammation, and remove underlying bacterial infection were initiated. Global anti-inflammatory lifestyle modifications were recommended. Within 3 months of treatment, the patient’s tTG antibodies decreased by 14% for the first time since strict gluten elimination. Within 15 months, tTG IgG antibodies were nearly normal at 1.61 (0.03-1.60, ELISA Index). Test results improved dramatically in tandem with clinical progress. On a GFD and after initiating and maintaining these dietary and lifestyle changes, he gained 12 inches and 40 pounds. To our knowledge, this is the first published case of complete reversal of NRCD and failure to thrive by addressing endotoxin and lifestyle outside of a GFD.
一名16岁的男孩,患有无反应性乳糜泻(NRCD),疱疹样皮炎,身材矮小,发育不良,尽管进行了10个月的无麸质饮食(GFD),但他的组织转谷氨酰胺酶(tTG)抗体过高,生长不良。免疫测试显示,针对小麦多肽、食物抗原、肠屏障功能障碍、脂多糖(LPS)抗体和多反应性自身免疫反应的抗体产生升高。消除饮食,营养品方案,以调节微生物组,解决肠道通透性,降低炎症,并消除潜在的细菌感染开始。建议改变全球抗炎生活方式。治疗3个月后,患者的tTG抗体下降了14%,这是自严格消除麸质以来的第一次。15个月内tTG IgG抗体1.61 (ELISA指数0.03 ~ 1.60)接近正常。随着临床进展,测试结果显著改善。在开始并维持这些饮食和生活方式的改变后,他的体重增加了12英寸,体重增加了40磅。据我们所知,这是首次发表的NRCD完全逆转的病例,通过解决内毒素和生活方式在GFD外生长失败。
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引用次数: 1
Awareness of Celiac Disease among the General Public in Saudi Arabia 沙特阿拉伯公众对乳糜泻的认识
Pub Date : 2021-05-18 DOI: 10.12691/IJCD-9-2-4
M. Alhussain
Background: Celiac disease (CD) is an immune-mediated systemic disorder triggered by dietary gluten and is considered one of the most common lifelong food-related disorders worldwide. The knowledge of CD among the general public in Saudi Arabia remains limited. Therefore, we aimed to assess the awareness and knowledge of CD among the general public in Saudi Arabia. Methods: A cross-sectional online survey including members of the general public was conducted in Saudi Arabia. The survey included questions assessing the public’s awareness about CD, gluten sensitivity, and peanut allergy, as well as celiac disease-related knowledge. Results: From a total of 1230 responses received, 76.7% (95% confidence interval [CI], 74.0%–79.4%) were females, 42.0% (95% CI, 37.7–46.3) were aged between 31–45 years, and 64.3% (95% CI, 61.0%–67.6%) had Bachelor’s degree. Less than half of the participants had heard of CD (48.4%; 95% CI, 44.4%–52.4%), but the majority had heard of peanut allergy (80.1%; 95% CI, 77.6%–82.6%) and gluten sensitivity (72.4%; 95% CI, 69.5%–75.3%). The prevalence of CD was estimated incorrectly by more than 80% of participants. Other questions on participants’ knowledge associated with CD were answered “Do not know” by the majority. Females demonstrated a greater awareness of CD, peanut allergy, and gluten sensitivity, and had a higher percentage of correct responses to questions related to CD than males. Conclusion: This study highlights the need to increase the awareness and knowledge of CD, especially in the recognition of its symptoms. Educational efforts toward increasing the awareness of the general public about CD could help optimize its diagnosis and management.
背景:乳糜泻(CD)是一种由膳食麸质引发的免疫介导的全身性疾病,被认为是世界范围内最常见的终身食物相关疾病之一。沙特阿拉伯公众对乳糜泻的了解仍然有限。因此,我们旨在评估沙特阿拉伯普通公众对乳糜泻的认识和知识。方法:在沙特阿拉伯进行了一项包括普通公众在内的横断面在线调查。该调查包括评估公众对乳糜泻、麸质敏感性、花生过敏以及乳糜泻相关知识的认识。结果:在收到的1230份回复中,76.7%(95%可信区间[CI], 74.0%-79.4%)为女性,42.0% (95% CI, 37.7-46.3)年龄在31-45岁之间,64.3% (95% CI, 61.0%-67.6%)为本科学历。不到一半的参与者听说过CD (48.4%;95% CI, 44.4%-52.4%),但大多数人听说过花生过敏(80.1%;95% CI, 77.6%-82.6%)和谷蛋白敏感性(72.4%;95% ci, 69.5%-75.3%)。超过80%的参与者对乳糜泻的患病率估计有误。其他关于参与者对乳糜泻相关知识的问题,大多数回答为“不知道”。女性对乳糜泻、花生过敏和麸质敏感的认识更高,对乳糜泻相关问题的正确率也高于男性。结论:本研究强调需要提高对乳糜泻的认识和认识,特别是对其症状的认识。提高公众对乳糜泻认识的教育工作有助于优化乳糜泻的诊断和管理。
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引用次数: 2
Antibiotic Resistance in Acute Cholecystitis Graded According to Tokyo Guidelines 2018: The First Prospective Study 根据2018年东京指南分级的急性胆囊炎抗生素耐药性:第一项前瞻性研究
Pub Date : 2021-05-18 DOI: 10.12691/IJCD-9-2-3
H. Patel, B. Vasavada
Introduction: Single-dose antibiotics are recommended for laparoscopic cholecystectomy, for symptomatic gall stones. However, very few studies are there for subgroup grade-2 and grade-3 cholecystitis according to Tokyo guidelines 2018. Material and methods: We retrospectively analysed outcomes of our protocol of no post-operative antibiotics in grade-2 and grade 3 (moderate to severe) acute cholecystitis according to Tokyo guidelines. We perform laparoscopic cholecystectomies within the first 24 hours of presentation to us without considering time since attack if the patient is not in septic shock where we follow survival sepsis guidelines and also perform percutaneous cholecystostomy. All the data were prospectively analysed. Statistical evaluation was done using SPSS version 21(IBM). Results: We performed 101 laparoscopic cholecystectomies between April 2016 to January 2019. We prefer single dose pre-operative antibiotic (third-generation cephalosporins) in all laparoscopic cholecystectomies and no post-operative antibiotics. A total of 74 patients were having grade 2 or grade 3 cholecystitis. 64 patients were having grade 2 and 9 patients were having grade 3 cholecystitis. One patient was having grade 3 cholecystitis and was having septic shock so he was managed with percutaneous cholecystostomy and according to survival sepsis protocol and lap choly was done after 72 hours and hence excluded from the study. Out of 73 patients included in the study, 2 patients were converted to open; in two patients we performed lap subtotal cholecystectomy due to a difficult calot triangle. Out of this only 1 patient developed port site infection and two patient developed biloma which was managed by percutaneous drainage. All patients were discharged the same day or the next day. Only two patients with biloma were readmitted. Rest all of the patients had an uneventful recovery. Conclusion: Post-operative antibiotics are unnecessary even in grade-2, grade-3 acute cholecystitis without septic shock according to Tokyo guidelines.
介绍:单剂量抗生素推荐用于腹腔镜胆囊切除术,用于症状性胆结石。然而,根据2018年东京指南,很少有针对二级和三级胆囊炎亚组的研究。材料和方法:我们根据东京指南回顾性分析了我们的2级和3级(中重度)急性胆囊炎术后无抗生素治疗方案的结果。如果患者没有脓毒性休克,我们会在就诊后的24小时内进行腹腔镜胆囊切除术,而不考虑发作后的时间。如果患者没有脓毒性休克,我们会遵循脓毒症生存指南,并进行经皮胆囊造口术。所有资料进行前瞻性分析。采用SPSS version 21(IBM)进行统计评价。结果:我院于2016年4月至2019年1月共施行腹腔镜胆囊切除术101例。在所有腹腔镜胆囊切除术中,我们倾向于术前单剂量抗生素(第三代头孢菌素),术后不使用抗生素。共有74例患者患有2级或3级胆囊炎。2级胆囊炎64例,3级胆囊炎9例。一名患者患有3级胆囊炎并患有感染性休克,因此他接受了经皮胆囊造口术,并根据生存败血症协议和72小时后进行了肝胆切除,因此被排除在研究之外。在纳入研究的73例患者中,2例患者转为开放;在两例患者中,由于胆囊三角形困难,我们进行了膝上胆囊次全切除术。其中只有1例患者发生端口感染,2例患者发生胆囊瘤,经皮引流治疗。所有患者均于当日或次日出院。只有2例胆囊瘤患者再次入院。其余的病人都顺利康复。结论:即使在没有感染性休克的2级、3级急性胆囊炎患者,根据东京指南,术后也不需要抗生素。
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引用次数: 0
期刊
International Journal of Celiac Disease
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