Here we are continuing interview articles and Professor Andras Arato from First Department of Paediatrics of the Semmelweis University in Budapest in Hungary is questioned.
{"title":"A Dialogue with Professor András Arató","authors":"G. Samașca","doi":"10.12691/IJCD-7-2-2","DOIUrl":"https://doi.org/10.12691/IJCD-7-2-2","url":null,"abstract":"Here we are continuing interview articles and Professor Andras Arato from First Department of Paediatrics of the Semmelweis University in Budapest in Hungary is questioned.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"247 1","pages":"58-62"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75757358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
10 year old with no significant history either in the past or family presented with tense ascites, hypochromic microcytic anemia, thrombocytosis and milky fluid with TAG level of 350 mg/dl with a SAAG of >1.1. LFT, chest xray and ascitic fluid ADA were normal. USG abdomen showed fine echoes from peritoneal cavity and normal liver and portal /hepatic veins. endoscopy was done to look for lymphangiectasia but gross morphology of duodenum was suggestive of celiac disease. Normal IgA, high anti TTG, biopsy marsh IIIB and clinical response to gluten free diet confirmed the diagnosis of celiac disease.
{"title":"Celiac Disease as Chylous Ascites in a Child","authors":"I. Malik, Jan Muzzafar, A. Omar","doi":"10.12691/IJCD-7-1-5","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-5","url":null,"abstract":"10 year old with no significant history either in the past or family presented with tense ascites, hypochromic microcytic anemia, thrombocytosis and milky fluid with TAG level of 350 mg/dl with a SAAG of >1.1. LFT, chest xray and ascitic fluid ADA were normal. USG abdomen showed fine echoes from peritoneal cavity and normal liver and portal /hepatic veins. endoscopy was done to look for lymphangiectasia but gross morphology of duodenum was suggestive of celiac disease. Normal IgA, high anti TTG, biopsy marsh IIIB and clinical response to gluten free diet confirmed the diagnosis of celiac disease.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"8 1","pages":"29-30"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83222919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celiac disease incidence is continuously increasing worldwide and in Africa, where a clear North to South gradient is apparent. At least in the Maghreb region, the disease features resemble its European neighbors, but some aspects are completely different. The present review highlights the underdiagnosis and the inadequate nutritional therapy for celiac disease patients and summarizes the local special circumstances that should be address to coop with the contemporary load and future burden of the disease.
{"title":"The Underdiagnosed Enemy: Africa Goes Celiac?","authors":"Lerner Aaron, Lopez Francois, Schmiedl Andreas, Matthias Torsten","doi":"10.12691/IJCD-7-1-3","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-3","url":null,"abstract":"Celiac disease incidence is continuously increasing worldwide and in Africa, where a clear North to South gradient is apparent. At least in the Maghreb region, the disease features resemble its European neighbors, but some aspects are completely different. The present review highlights the underdiagnosis and the inadequate nutritional therapy for celiac disease patients and summarizes the local special circumstances that should be address to coop with the contemporary load and future burden of the disease.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"8 1","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75639408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rheumatoid arthritis (RA) and celiac disease (CD) belong to the autoimmune disease family. Even though these diseases are separate entities, they share multiple aspects. This association has rarely been reported. We had the opportunity to study the case of a patient with CD and RA.
{"title":"Coeliac Disease with Rheumatoid Arthritis: An Unusual Association","authors":"A. Mounir, N. Akasbi, N. Siar, T. Harzy","doi":"10.12691/IJCD-7-1-1","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-1","url":null,"abstract":"Rheumatoid arthritis (RA) and celiac disease (CD) belong to the autoimmune disease family. Even though these diseases are separate entities, they share multiple aspects. This association has rarely been reported. We had the opportunity to study the case of a patient with CD and RA.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"31 1","pages":"26-28"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84524298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The “mosaic of autoimmunity” is a complex, multiple-faceted, challenging scientific enigma. Celiac disease and rheumatoid arthritis are part of the autoimmune bee hive and despite being separate entities, they share multiple aspects. The present review summarizes the epidemiological, clinical, serological, genetic, environmental, enteric eco-events and associated diseases shared by the two mechanistically similar though different antigenic entities.
{"title":"The Gut Feeling of the Joints: Celiac Disease and Rheumatoid Arthritis Are Related","authors":"Lerner Aaron, Wusterhausen Patricia, Ramesh Ajay, Lopez Francois, Matthias Torsten","doi":"10.12691/IJCD-7-1-7","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-7","url":null,"abstract":"The “mosaic of autoimmunity” is a complex, multiple-faceted, challenging scientific enigma. Celiac disease and rheumatoid arthritis are part of the autoimmune bee hive and despite being separate entities, they share multiple aspects. The present review summarizes the epidemiological, clinical, serological, genetic, environmental, enteric eco-events and associated diseases shared by the two mechanistically similar though different antigenic entities.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"11 1","pages":"21-25"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83789546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Collagenous sprue is a disorder characterized by severe diarrhea, progressive malaborption of multiple nutrients, protein depletion and weight loss accompanied by a pathognomic small bowel biopsy lesion characterized by a villus atrophy and a band-like subsepithelial mucosal deposit containing collagen. It has been closely linked to celiac disease, tends to be refractory to treatment and prognosis has been poor with only anecdotes of successful therapy. In recent years, the disorder has been detected in different settings, including early malignancies as a paraneoplastic phenomenon and due to the toxic effects of some medications including non-steroidal anti-inflammatory drugs (NSAIDs) and the angiotensin II receptor antagonist, olmesartan. Here, dramatic reversal to normal of the clinical and pathological changes have been documented so that a medication history is critical in any patient presenting with sprue-like intestinal disease.
{"title":"Collagenous Sprue, a Heterogeneous Small Bowel Disorder","authors":"H. Freeman","doi":"10.12691/IJCD-7-1-2","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-2","url":null,"abstract":"Collagenous sprue is a disorder characterized by severe diarrhea, progressive malaborption of multiple nutrients, protein depletion and weight loss accompanied by a pathognomic small bowel biopsy lesion characterized by a villus atrophy and a band-like subsepithelial mucosal deposit containing collagen. It has been closely linked to celiac disease, tends to be refractory to treatment and prognosis has been poor with only anecdotes of successful therapy. In recent years, the disorder has been detected in different settings, including early malignancies as a paraneoplastic phenomenon and due to the toxic effects of some medications including non-steroidal anti-inflammatory drugs (NSAIDs) and the angiotensin II receptor antagonist, olmesartan. Here, dramatic reversal to normal of the clinical and pathological changes have been documented so that a medication history is critical in any patient presenting with sprue-like intestinal disease.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"4 1","pages":"13-15"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85108976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Sur, A. Aldea, Loredana Dascăl, E. Duca, C. Silaghi, L. Sur, C. Aldea
Patients affected by non-celiac gluten sensitivity usually report both intestinal and extra-intestinal symptoms arising shortly after the ingestion of gluten-containing food. Atopic dermatitis is a chronic inflammatory skin disease that affects both children and adults. We present the case of a family composed of a mother (32 years old) and her two daughters (6 and 9 years old) who were diagnosed with atopic dermatitis and gluten related disorders.
{"title":"The Link between the Clinical Features of Atopic Dermatitis and Gluten-related Disorders","authors":"M. Sur, A. Aldea, Loredana Dascăl, E. Duca, C. Silaghi, L. Sur, C. Aldea","doi":"10.12691/IJCD-7-1-6","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-6","url":null,"abstract":"Patients affected by non-celiac gluten sensitivity usually report both intestinal and extra-intestinal symptoms arising shortly after the ingestion of gluten-containing food. Atopic dermatitis is a chronic inflammatory skin disease that affects both children and adults. We present the case of a family composed of a mother (32 years old) and her two daughters (6 and 9 years old) who were diagnosed with atopic dermatitis and gluten related disorders.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"97 1","pages":"31-32"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73610326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Chojdak-Łukasiewicz, E. Dziadkowiak, Małgorzata Błauciak, B. Paradowski
Coeliac disease (CD) is a chronic autoimmune enteropathy of the small intestine that occurs in genetically predisposed individuals. It is characterized by atrophy of intestinal villi accompanied by an increase in the number of intraepithelial lymphocytes and crypt hypertrophy as well as the presence of specific endomysial antibodies (EMA), IgA tissue transglutaminase antibodies (IgA-tTG), and IgA and IgG deaminated gliadin peptide antibodies (DGP IgA and IgG). CD is associated with a wide spectrum of clinical signs and symptoms secondary to malabsorption (vitamin deficiency, anaemia, osteoporosis) or unrelated to the gastrointestinal tract. Neurological disorders are a common problem in patients with CD and are not always accompanied by gastrointestinal symptoms. The most common neurological manifestations of CD are cerebellar ataxia, epilepsy, and peripheral neuropathy.
{"title":"Neurological Complications of Coeliac Disease","authors":"J. Chojdak-Łukasiewicz, E. Dziadkowiak, Małgorzata Błauciak, B. Paradowski","doi":"10.12691/IJCD-7-1-8","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-8","url":null,"abstract":"Coeliac disease (CD) is a chronic autoimmune enteropathy of the small intestine that occurs in genetically predisposed individuals. It is characterized by atrophy of intestinal villi accompanied by an increase in the number of intraepithelial lymphocytes and crypt hypertrophy as well as the presence of specific endomysial antibodies (EMA), IgA tissue transglutaminase antibodies (IgA-tTG), and IgA and IgG deaminated gliadin peptide antibodies (DGP IgA and IgG). CD is associated with a wide spectrum of clinical signs and symptoms secondary to malabsorption (vitamin deficiency, anaemia, osteoporosis) or unrelated to the gastrointestinal tract. Neurological disorders are a common problem in patients with CD and are not always accompanied by gastrointestinal symptoms. The most common neurological manifestations of CD are cerebellar ataxia, epilepsy, and peripheral neuropathy.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"54 1","pages":"16-20"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91325145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Yorulmaz, Pınar Neva Fındık, Meltem Aksoy, Rüya Akbayrak, G. Genç, H. Yorulmaz
The study was conducted to investigate the factors affecting the perception of disease and coping attitudes in patients with celiac disease. The study was conducted with 100 celiac patients in Istanbul. The data were collected by applying “Introductory Information Form”, “Illness Perception Questionnaire”, and “Coping Inventory”. In the statistical analysis, t-test, Tukey and Pearson Correlation Analysis were used. It was observed that 63% of the patients were female, 52% were single, 21% were overweight. It was determined that there was a significant difference in terms of gender, marital status and income level, diet list, difficulty in dietary compliance in coping inventory (p<0.05). It was observed that the patients were emotionally affected by their diseases and exhibited problem-focused coping behaviors from coping attitudes. It was determined that there was a negative correlation between the patients’ age and illness coherence and emotional representations and between diagnosis time and emotional representation, personal attribution, lifestyle and chance factor (p<0.01). It was determined that there was a negative correlation between the dieting duration and emotional representations, personal attribution, lifestyle and chance factor (p<0.01). It was seen that there was a positive correlation between the age and problem-focused coping method and a negative correlation between the age and the dysfunctional subscale (p<0.01). It was seen that there was a positive correlation between the timeline (acute/chronic) and emotional-focused coping subscales, between personal control and problem focused and emotional focused coping subscales and between the treatment control and emotional focused coping subscale (p<0.05). It was also observed that 88% of the patients experienced symptoms like constipation and diarrhea, perceived their diseases as chronic, and the disease affected their physical, social and psychological functions. It may be recommended to comprehensively examine especially the factors obstructing their dietary compliance and influencing perception of disease.
{"title":"Perception of Disease and Coping Attitudes in Patients with Celiac Disease","authors":"E. Yorulmaz, Pınar Neva Fındık, Meltem Aksoy, Rüya Akbayrak, G. Genç, H. Yorulmaz","doi":"10.12691/IJCD-7-1-4","DOIUrl":"https://doi.org/10.12691/IJCD-7-1-4","url":null,"abstract":"The study was conducted to investigate the factors affecting the perception of disease and coping attitudes in patients with celiac disease. The study was conducted with 100 celiac patients in Istanbul. The data were collected by applying “Introductory Information Form”, “Illness Perception Questionnaire”, and “Coping Inventory”. In the statistical analysis, t-test, Tukey and Pearson Correlation Analysis were used. It was observed that 63% of the patients were female, 52% were single, 21% were overweight. It was determined that there was a significant difference in terms of gender, marital status and income level, diet list, difficulty in dietary compliance in coping inventory (p<0.05). It was observed that the patients were emotionally affected by their diseases and exhibited problem-focused coping behaviors from coping attitudes. It was determined that there was a negative correlation between the patients’ age and illness coherence and emotional representations and between diagnosis time and emotional representation, personal attribution, lifestyle and chance factor (p<0.01). It was determined that there was a negative correlation between the dieting duration and emotional representations, personal attribution, lifestyle and chance factor (p<0.01). It was seen that there was a positive correlation between the age and problem-focused coping method and a negative correlation between the age and the dysfunctional subscale (p<0.01). It was seen that there was a positive correlation between the timeline (acute/chronic) and emotional-focused coping subscales, between personal control and problem focused and emotional focused coping subscales and between the treatment control and emotional focused coping subscale (p<0.05). It was also observed that 88% of the patients experienced symptoms like constipation and diarrhea, perceived their diseases as chronic, and the disease affected their physical, social and psychological functions. It may be recommended to comprehensively examine especially the factors obstructing their dietary compliance and influencing perception of disease.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"13 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2019-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82344609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The expanding knowledge about gluten-related autoimmunity led to a serology-based step-wised approach to diagnose celiac disease that might be misleading due to laboratory techniques. We present a rare case associating initial false-negative anti-transglutaminase IgA antibodies while CD was confirmed by IgG anti-transglutaminase and subsequent duodenal biopsy.
{"title":"False-negative IgA Anti-tissue Transglutaminase","authors":"N. Boutrid, H. Rahmoune, M. Amrane","doi":"10.12691/ijcd-6-3-2","DOIUrl":"https://doi.org/10.12691/ijcd-6-3-2","url":null,"abstract":"The expanding knowledge about gluten-related autoimmunity led to a serology-based step-wised approach to diagnose celiac disease that might be misleading due to laboratory techniques. We present a rare case associating initial false-negative anti-transglutaminase IgA antibodies while CD was confirmed by IgG anti-transglutaminase and subsequent duodenal biopsy.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"171 1","pages":"87-88"},"PeriodicalIF":0.0,"publicationDate":"2019-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81114186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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