首页 > 最新文献

International Journal of Celiac Disease最新文献

英文 中文
Covid-19 and the Human Gut: A New Runner on the Tract Covid-19和人类肠道:肠道上的新奔跑者
Pub Date : 2020-06-25 DOI: 10.12691/IJCD-8-2-7
Lerner Aaron
The severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) dwells in the respiratory airways, however, its digestive tract presence, infectivity, mucosal attachment and penetrating mechanisms, enteric proliferation, stool shading, flashed bio-aerosol spreading and fecal-oral transmission is far from being understood. The present review opens some skylights to lighten the long, tortuous, dark and challenging tunnel of the gastrointestinal tract and his uninvited covid-19 viral new inhabitant.
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)存在于呼吸道,但其在消化道的存在、传染性、粘膜附着和穿透机制、肠道增殖、粪便遮蔽、闪现生物气溶胶传播和粪口传播等尚不清楚。本综述打开了一些天窗,照亮了胃肠道的漫长、曲折、黑暗和具有挑战性的隧道,以及他不请自来的covid-19病毒新居民。
{"title":"Covid-19 and the Human Gut: A New Runner on the Tract","authors":"Lerner Aaron","doi":"10.12691/IJCD-8-2-7","DOIUrl":"https://doi.org/10.12691/IJCD-8-2-7","url":null,"abstract":"The severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) dwells in the respiratory airways, however, its digestive tract presence, infectivity, mucosal attachment and penetrating mechanisms, enteric proliferation, stool shading, flashed bio-aerosol spreading and fecal-oral transmission is far from being understood. The present review opens some skylights to lighten the long, tortuous, dark and challenging tunnel of the gastrointestinal tract and his uninvited covid-19 viral new inhabitant.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"40 1","pages":"64-67"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78374441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Risks of Lymphoma and Digestive Cancers in Patients with Celiac Disease: Cohort Study 乳糜泻患者淋巴瘤和消化道癌的风险:队列研究
Pub Date : 2020-06-25 DOI: 10.12691/IJCD-8-2-2
A. Mahmoudi, I. Benelbarhdadi, C. Berhili, N. Lagdali, M. Borahma, F. Ajana
BACKGROUND: The association between celiac disease (CD) and the development of various malignant tumors, in particular gastrointestinal cancers, has been reported by several studies. However, the close relative risks (Odds Ratio) of these complications compared to the population are still insufficiently known and estimates of the risk factors for the development of these complications in patients followed for CD remain controversial. Objective: To estimate the close relative risks of malignant complications in a cohort of patients with celiac disease compared to the Moroccan population and to determine the risk factors for the development of these complications. Methods: Our work is a retrospective, descriptive and analytical study, carried out within the Department of Medicine C of the CHU IBN SINA Mohammed V University of Rabat, over a period of 23 years - between 1995 and 2018 -, and on a basis of 284 cases of celiac disease, from which we have extracted a series of 16 cases of celiac disease with at least one malignant gastrointestinal complication. Using a case-control study, we were able to determine the risk of these complications compared to the general Moroccan population. Results: We gathered a population of 16 celiac patients with one or more malignant gastrointestinal complications, out of a total of 284 cases of CD, the prevalence was 5.6%. We found a significant increase in the risk of developing digestive malignancies during CD with an Odds Ratio (OR) of 46 (95% confidence interval [CI] 34–63) and p value <0.0001). This risk was higher during the period of per diagnosis, we also objectified a significant increase in risk of all types of cancers found in our series compared to those of control cases. The two risk factors for malignant complications found in our study are non-compliance with the gluten-free diet and delayed diagnosis. Conclusions: There is a significant increase in the risk of malignancy in patients diagnosed with CD. Particularly during the period of per diagnosis. This risk according to this cohort can be reduced by the good observance of the gluten-free diet and an early diagnosis in the face of the most severe symptoms of this pathology.
背景:一些研究已经报道了乳糜泻(CD)与各种恶性肿瘤,特别是胃肠道癌症的发展之间的关系。然而,与人群相比,这些并发症的密切相关风险(优势比)仍然不够清楚,对乳糜泻随访患者发生这些并发症的危险因素的估计仍然存在争议。目的:与摩洛哥人群相比,估计一组乳糜泻患者恶性并发症的近亲属风险,并确定这些并发症发生的危险因素。方法:我们的工作是一项回顾性,描述性和分析性研究,在拉巴特的CHU IBN SINA Mohammed五世大学医学C系进行,为期23年(1995年至2018年),在284例乳糜泻的基础上,我们从中提取了16例至少伴有一种恶性胃肠道并发症的乳糜泻。通过病例对照研究,我们能够确定与一般摩洛哥人群相比这些并发症的风险。结果:我们收集了16例伴有一种或多种恶性胃肠道并发症的乳糜泻患者,其中共284例CD,患病率为5.6%。我们发现,在CD期间发生消化道恶性肿瘤的风险显著增加,优势比(OR)为46(95%可信区间[CI] 34-63), p值<0.0001)。在每次诊断期间,这种风险更高,我们也客观地发现,与对照病例相比,我们系列中发现的所有类型癌症的风险都显著增加。在我们的研究中发现的恶性并发症的两个危险因素是不遵守无麸质饮食和延迟诊断。结论:诊断为乳糜泻的患者发生恶性肿瘤的风险显著增加,特别是在每次诊断期间。根据这个队列,这种风险可以通过良好地遵守无麸质饮食和面对最严重的病理症状的早期诊断来降低。
{"title":"Risks of Lymphoma and Digestive Cancers in Patients with Celiac Disease: Cohort Study","authors":"A. Mahmoudi, I. Benelbarhdadi, C. Berhili, N. Lagdali, M. Borahma, F. Ajana","doi":"10.12691/IJCD-8-2-2","DOIUrl":"https://doi.org/10.12691/IJCD-8-2-2","url":null,"abstract":"BACKGROUND: The association between celiac disease (CD) and the development of various malignant tumors, in particular gastrointestinal cancers, has been reported by several studies. However, the close relative risks (Odds Ratio) of these complications compared to the population are still insufficiently known and estimates of the risk factors for the development of these complications in patients followed for CD remain controversial. Objective: To estimate the close relative risks of malignant complications in a cohort of patients with celiac disease compared to the Moroccan population and to determine the risk factors for the development of these complications. Methods: Our work is a retrospective, descriptive and analytical study, carried out within the Department of Medicine C of the CHU IBN SINA Mohammed V University of Rabat, over a period of 23 years - between 1995 and 2018 -, and on a basis of 284 cases of celiac disease, from which we have extracted a series of 16 cases of celiac disease with at least one malignant gastrointestinal complication. Using a case-control study, we were able to determine the risk of these complications compared to the general Moroccan population. Results: We gathered a population of 16 celiac patients with one or more malignant gastrointestinal complications, out of a total of 284 cases of CD, the prevalence was 5.6%. We found a significant increase in the risk of developing digestive malignancies during CD with an Odds Ratio (OR) of 46 (95% confidence interval [CI] 34–63) and p value <0.0001). This risk was higher during the period of per diagnosis, we also objectified a significant increase in risk of all types of cancers found in our series compared to those of control cases. The two risk factors for malignant complications found in our study are non-compliance with the gluten-free diet and delayed diagnosis. Conclusions: There is a significant increase in the risk of malignancy in patients diagnosed with CD. Particularly during the period of per diagnosis. This risk according to this cohort can be reduced by the good observance of the gluten-free diet and an early diagnosis in the face of the most severe symptoms of this pathology.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"40 1","pages":"50-53"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74274694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celiac Disease Presenting as Cardiomyopathy - A Rare Extra Intestinal Manifestation 乳糜泻表现为心肌病-一种罕见的肠外表现
Pub Date : 2020-06-25 DOI: 10.12691/IJCD-8-2-4
Shravan K. Bohra, Apurva S. Shah
Cardiac manifestations of celiac disease has been poorly described in literature though some studies have emphasized on correlation of ischemic heart disease, atrial fibrillation and dilated cardiomyopathy with celiac disease. We describe a patient with celiac disease associated cardiomyopathy whose cardiac function improved substantially after treatment with a gluten-free diet. A young lady of 35 years age was admitted with complaints of chronic diarrhea, vomiting, significant weight loss, dizziness and chronic iron deficiency anemia since last 3 months. Physical examination revealed tachycardia, tachypnoea and hypotension requiring multiple high dose inotropic support. She had pallor, skin changes and pedal edema suggestive of malabsorption. Investigations revealed iron deficiency anemia, high bilirubin and transaminases, prothrombin time, low albumin and elevated tissue trasglutaminase antibody. Echocardiography showed global hypokinesia with a left ventricular ejection fraction of 20%. Diagnosis of celiac disease made on clinic features, serology and biopsy finding of subtotal villous atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes. She was kept on gluten free diet and on intravenous steroids for acute celiac crises and celiac related cardiomyopathy as patient had severe diarrhea, hypocalcaemia, weight loss, hypoproteinemia and hypotension. Patient improved within 48 hours of steroid with discontinuation of inotropes. She was discharged with gluten free diet and follow up after 6 months showed near normalization of all biochemical abnormalities and ejection fraction of 55%. Cardiomyopathy associated with celiac disease and celiac crisis is a serious and potentially lethal condition. However, with early diagnosis and treatment with a gluten free diet, and steroids cardiomyopathy in patients with celiac disease may be completely reversible.
虽然一些研究强调了缺血性心脏病、心房颤动和扩张型心肌病与乳糜泻的相关性,但文献对乳糜泻的心脏表现描述较少。我们描述了一个患有乳糜泻相关心肌病的病人,他的心功能在无麸质饮食治疗后得到了很大的改善。一位35岁的年轻女士因慢性腹泻、呕吐、体重明显减轻、头晕和慢性缺铁性贫血3个月来就诊。体格检查显示心动过速、呼吸急促和低血压,需要多次大剂量的肌力支持。她面色苍白,皮肤变化和足部水肿提示吸收不良。调查显示缺铁性贫血,高胆红素和转氨酶,凝血酶原时间,低白蛋白和组织谷氨酰胺酶抗体升高。超声心动图显示整体运动不足,左心室射血分数为20%。乳糜泻的诊断主要依据临床特征、血清学和活检结果:绒毛大部萎缩、隐窝增生和上皮内淋巴细胞增加。由于患者有严重腹泻、低钙血症、体重减轻、低蛋白血症和低血压,她坚持无麸质饮食和静脉注射类固醇治疗急性乳糜泻危象和乳糜泻相关心肌病。患者在停用肌力药物后48小时内类固醇得到改善。出院时采用无麸质饮食,6个月后随访,所有生化异常接近正常,射血分数为55%。与乳糜泻和乳糜泻危象相关的心肌病是一种严重且具有潜在致命性的疾病。然而,通过早期诊断和无麸质饮食治疗,乳糜泻患者的心肌病可能是完全可逆的。
{"title":"Celiac Disease Presenting as Cardiomyopathy - A Rare Extra Intestinal Manifestation","authors":"Shravan K. Bohra, Apurva S. Shah","doi":"10.12691/IJCD-8-2-4","DOIUrl":"https://doi.org/10.12691/IJCD-8-2-4","url":null,"abstract":"Cardiac manifestations of celiac disease has been poorly described in literature though some studies have emphasized on correlation of ischemic heart disease, atrial fibrillation and dilated cardiomyopathy with celiac disease. We describe a patient with celiac disease associated cardiomyopathy whose cardiac function improved substantially after treatment with a gluten-free diet. A young lady of 35 years age was admitted with complaints of chronic diarrhea, vomiting, significant weight loss, dizziness and chronic iron deficiency anemia since last 3 months. Physical examination revealed tachycardia, tachypnoea and hypotension requiring multiple high dose inotropic support. She had pallor, skin changes and pedal edema suggestive of malabsorption. Investigations revealed iron deficiency anemia, high bilirubin and transaminases, prothrombin time, low albumin and elevated tissue trasglutaminase antibody. Echocardiography showed global hypokinesia with a left ventricular ejection fraction of 20%. Diagnosis of celiac disease made on clinic features, serology and biopsy finding of subtotal villous atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes. She was kept on gluten free diet and on intravenous steroids for acute celiac crises and celiac related cardiomyopathy as patient had severe diarrhea, hypocalcaemia, weight loss, hypoproteinemia and hypotension. Patient improved within 48 hours of steroid with discontinuation of inotropes. She was discharged with gluten free diet and follow up after 6 months showed near normalization of all biochemical abnormalities and ejection fraction of 55%. Cardiomyopathy associated with celiac disease and celiac crisis is a serious and potentially lethal condition. However, with early diagnosis and treatment with a gluten free diet, and steroids cardiomyopathy in patients with celiac disease may be completely reversible.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"34 1","pages":"56-57"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77685380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celiac Disease Complicated by a Rare, Ulcerative Duodenal Adenocarcinoma 乳糜泻并发罕见的溃疡性十二指肠腺癌
Pub Date : 2020-06-25 DOI: 10.12691/IJCD-8-2-3
N. Boutrid, H. Rahmoune, M. Amrane, A. Bataiche, N. Lemdaoui
Celiac Disease (CD) is an autoimmune condition that is well-known to be associated with increased risk of malignancies, specifically gastro-intestinal neoplasms. We report a case of a young male patient with CD presenting with an ulcerative duodenal adenocarcinoma, successfully operated by cephalic pancreaticoduodenectomy.
乳糜泻(CD)是一种自身免疫性疾病,众所周知,它与恶性肿瘤,特别是胃肠道肿瘤的风险增加有关。我们报告一例年轻的男性乳糜泻患者表现为溃疡性十二指肠腺癌,成功地进行了头侧胰十二指肠切除术。
{"title":"Celiac Disease Complicated by a Rare, Ulcerative Duodenal Adenocarcinoma","authors":"N. Boutrid, H. Rahmoune, M. Amrane, A. Bataiche, N. Lemdaoui","doi":"10.12691/IJCD-8-2-3","DOIUrl":"https://doi.org/10.12691/IJCD-8-2-3","url":null,"abstract":"Celiac Disease (CD) is an autoimmune condition that is well-known to be associated with increased risk of malignancies, specifically gastro-intestinal neoplasms. We report a case of a young male patient with CD presenting with an ulcerative duodenal adenocarcinoma, successfully operated by cephalic pancreaticoduodenectomy.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"39 1","pages":"54-55"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86984855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 Diarrhea
Pub Date : 2020-06-25 DOI: 10.12691/IJCD-8-2-6
H. Freeman
In 2019, a novel virus emerged in Wuhan, China that caused a febrile respiratory illness, sometimes rapidly fatal and thought to be transmitted by droplet contact. It likely originated from another species (possibly the bat), but later, spread occurred from human-to-human. Over a period of months, this disease disseminated to more than 100 nations as a highly infectious pandemic, reminiscent of disease associated with other coronavirus agents in 2002 (SARS) and 2012 (MERS). This COVID-19 virus also caused other forms of clinical illness, albeit in the minority, and most infected patients (over 50%) had few symptoms or remained completely asymptomatic. Prominent in some patients was watery diarrhea, often lasting less than a week, but sometimes without any respiratory features, such as fever, cough or shortness of breath. It is believed that fecal-oral transmission may result. The virus attaches to the surface of human respiratory and intestinal cells, gains entry into these cells, ultimately leading to production of new virions intraluminally. Fecal shedding may occur for extended periods, even after respiratory secretions become negative. Apart from preventive measures, vaccine development remains the most important strategy.
2019年,一种新型病毒在中国武汉出现,导致一种发热性呼吸道疾病,有时会迅速致命,被认为是通过飞沫接触传播的。它可能起源于另一个物种(可能是蝙蝠),但后来发生了人与人之间的传播。在几个月的时间里,这种疾病作为一种高度传染性的大流行传播到100多个国家,让人想起2002年(SARS)和2012年(MERS)与其他冠状病毒病原体相关的疾病。这种COVID-19病毒还引起其他形式的临床疾病,尽管是少数,大多数感染患者(超过50%)几乎没有症状或完全无症状。一些患者的突出症状是水样腹泻,通常持续不到一周,但有时没有任何呼吸症状,如发烧、咳嗽或呼吸短促。据信可能导致粪口传播。病毒附着在人类呼吸道和肠道细胞表面,进入这些细胞,最终导致细胞内产生新的病毒粒子。即使在呼吸道分泌物呈阴性后,粪便脱落也可能持续较长时间。除了预防措施外,疫苗开发仍然是最重要的战略。
{"title":"COVID-19 Diarrhea","authors":"H. Freeman","doi":"10.12691/IJCD-8-2-6","DOIUrl":"https://doi.org/10.12691/IJCD-8-2-6","url":null,"abstract":"In 2019, a novel virus emerged in Wuhan, China that caused a febrile respiratory illness, sometimes rapidly fatal and thought to be transmitted by droplet contact. It likely originated from another species (possibly the bat), but later, spread occurred from human-to-human. Over a period of months, this disease disseminated to more than 100 nations as a highly infectious pandemic, reminiscent of disease associated with other coronavirus agents in 2002 (SARS) and 2012 (MERS). This COVID-19 virus also caused other forms of clinical illness, albeit in the minority, and most infected patients (over 50%) had few symptoms or remained completely asymptomatic. Prominent in some patients was watery diarrhea, often lasting less than a week, but sometimes without any respiratory features, such as fever, cough or shortness of breath. It is believed that fecal-oral transmission may result. The virus attaches to the surface of human respiratory and intestinal cells, gains entry into these cells, ultimately leading to production of new virions intraluminally. Fecal shedding may occur for extended periods, even after respiratory secretions become negative. Apart from preventive measures, vaccine development remains the most important strategy.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"11 1","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83860261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Bovine Milk Proteins as a Trigger for Autoimmune Diseases: Myth or Reality? 牛乳蛋白引发自身免疫性疾病:神话还是现实?
Pub Date : 2020-05-01 DOI: 10.12691/IJCD-8-1-3
V. Borba, A. Lerner, T. Matthias, Y. Shoenfeld
Humans started to drinkmammal’s milk 11,000 years ago. Nowadays, cow, goat and sheep milks account for about 87% of the world milk production. The high incidence of allergies to cow’s milk components and autoimmune diseases is rising in the Western industrialized countries, where milk is a major dietary component, especially in processed foods. When allergenic milk proteins face immature and susceptible immune system in children it might represent a threat for future health. Several studies support strong evidences that exposure to dietary allergens during childhood can increase the risk of developing autoimmune diseases, such as type 1 diabetes, celiac disease, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, neuropsychiatric disorders, among others. The "Mosaic of Autoimmunity" elucidates the diversity and multifactorial origin of autoimmune disease expression in humans. Growing evidence suggests a large overlap between oral tolerance, food antigens and autoimmune diseases. Assorted mechanisms have been hypothesized to explain the connection between these entities, mainly involving molecular mimicry, shared epitopes, cross-reactivity phenomena, enhanced hosts gut permeability, change in microbiome/ dysbiome ratio and even involving Mycobacterium avium subspecies paratuberculosis infection. Nowadays, different kinds of milk and dairy products are being evaluated for a potential benefit in human health. Likewise, milk derived nutraceutical products, such as bovine colostrum, claim many clinical advantages especially for its immune modulatory capabilities. The aim of this review is to explore the impact of cow’s milk protein son human health, emphasizing its relationship with immune mediated and autoimmune diseases.
人类在11000年前开始喝哺乳动物的奶。如今,牛奶、山羊奶和绵羊奶约占世界牛奶产量的87%。在西方工业化国家,牛奶是主要的饮食成分,尤其是加工食品中的牛奶,对牛奶成分过敏和自身免疫性疾病的高发率正在上升。当过敏性牛奶蛋白面对不成熟和敏感的儿童免疫系统时,它可能对未来的健康构成威胁。一些研究有力地证明,儿童时期接触食物过敏原会增加自身免疫性疾病的风险,如1型糖尿病、乳糜泻、炎症性肠病、类风湿关节炎、多发性硬化症、神经精神疾病等。“自身免疫马赛克”阐明了人类自身免疫性疾病表达的多样性和多因子起源。越来越多的证据表明,口腔耐受、食物抗原和自身免疫性疾病之间存在很大的重叠。各种各样的机制被假设来解释这些实体之间的联系,主要涉及分子模仿、共享表位、交叉反应现象、宿主肠道通透性增强、微生物组/菌群失调比例的变化,甚至涉及鸟分枝杆菌亚种副结核感染。如今,人们正在评估不同种类的牛奶和乳制品对人体健康的潜在益处。同样,牛奶衍生的营养保健品,如牛初乳,声称具有许多临床优势,特别是其免疫调节能力。本文旨在探讨牛奶蛋白对人体健康的影响,强调其与免疫介导和自身免疫性疾病的关系。
{"title":"Bovine Milk Proteins as a Trigger for Autoimmune Diseases: Myth or Reality?","authors":"V. Borba, A. Lerner, T. Matthias, Y. Shoenfeld","doi":"10.12691/IJCD-8-1-3","DOIUrl":"https://doi.org/10.12691/IJCD-8-1-3","url":null,"abstract":"Humans started to drinkmammal’s milk 11,000 years ago. Nowadays, cow, goat and sheep milks account for about 87% of the world milk production. The high incidence of allergies to cow’s milk components and autoimmune diseases is rising in the Western industrialized countries, where milk is a major dietary component, especially in processed foods. When allergenic milk proteins face immature and susceptible immune system in children it might represent a threat for future health. Several studies support strong evidences that exposure to dietary allergens during childhood can increase the risk of developing autoimmune diseases, such as type 1 diabetes, celiac disease, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, neuropsychiatric disorders, among others. The \"Mosaic of Autoimmunity\" elucidates the diversity and multifactorial origin of autoimmune disease expression in humans. Growing evidence suggests a large overlap between oral tolerance, food antigens and autoimmune diseases. Assorted mechanisms have been hypothesized to explain the connection between these entities, mainly involving molecular mimicry, shared epitopes, cross-reactivity phenomena, enhanced hosts gut permeability, change in microbiome/ dysbiome ratio and even involving Mycobacterium avium subspecies paratuberculosis infection. Nowadays, different kinds of milk and dairy products are being evaluated for a potential benefit in human health. Likewise, milk derived nutraceutical products, such as bovine colostrum, claim many clinical advantages especially for its immune modulatory capabilities. The aim of this review is to explore the impact of cow’s milk protein son human health, emphasizing its relationship with immune mediated and autoimmune diseases.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"30 1","pages":"10-21"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88971179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A New Tool in the Development of Celiac Disease: Sense of Coherence Score 乳糜泻发展的新工具:连贯性感评分
Pub Date : 2020-05-01 DOI: 10.12691/IJCD-8-1-1
Adi Eindor-Abarbanel, Dana ZelnikYovel, T. Naftali, N. Ruhimovich, T. Shalem, S. Matalon, H. Shirin, T. Ziv-Baran, E. Broide
Introduction: Sense of Coherence (SOC) is a theoretical construct that was developed to explain why some people become ill and others do not, regardless of stressful events. Low SOC was reported to correlate with the development of several multifactorial, chronic diseases such as diabetes mellitus and systemic lupus erythematosus. Aims: To compare the SOC scores of patients diagnosed with celiac disease (CD) and matched healthy controls to investigate possible correlations between low SOC scores and CD. Patients and Methods: Patients provided demographic data and completed the 13-item SOC questionnaire. Patients in the study cohort were matched to healthy controls according to age, gender, education, income, employment status and marital status. Results: A total of 239 CD patients and 124 healthy controls answered the SOC questionnaire. Among them,124 patients were matched to the healthy cohort according to propensity score. CD patients had a median SOC score of 57 (IQR 52.25-62), and controls 65.5 (IQR 57-75) pConclusions: SOC reflects a person's resources and orientation which enable individuals to cope with stressors in a way that promotes health. Lower SOC score is correlated with the development of CD.
连贯性感(SOC)是一种理论结构,它被用来解释为什么有些人会生病,而另一些人不会,而不管压力事件。据报道,低SOC与糖尿病和系统性红斑狼疮等多种多因素慢性疾病的发展有关。目的:比较诊断为乳糜泻(CD)的患者和匹配的健康对照者的SOC评分,以探讨低SOC评分与CD之间可能的相关性。患者和方法:患者提供人口学数据并完成13项SOC问卷。研究队列中的患者根据年龄、性别、教育程度、收入、就业状况和婚姻状况与健康对照进行匹配。结果:共有239名CD患者和124名健康对照者回答了SOC问卷。其中124例患者按倾向评分与健康队列匹配。CD患者SOC得分中位数为57分(IQR 52.25-62),对照组为65.5分(IQR 57-75)。结论:SOC反映了一个人的资源和取向,使个体能够以促进健康的方式应对压力源。较低的SOC评分与CD的发展相关。
{"title":"A New Tool in the Development of Celiac Disease: Sense of Coherence Score","authors":"Adi Eindor-Abarbanel, Dana ZelnikYovel, T. Naftali, N. Ruhimovich, T. Shalem, S. Matalon, H. Shirin, T. Ziv-Baran, E. Broide","doi":"10.12691/IJCD-8-1-1","DOIUrl":"https://doi.org/10.12691/IJCD-8-1-1","url":null,"abstract":"Introduction: Sense of Coherence (SOC) is a theoretical construct that was developed to explain why some people become ill and others do not, regardless of stressful events. Low SOC was reported to correlate with the development of several multifactorial, chronic diseases such as diabetes mellitus and systemic lupus erythematosus. Aims: To compare the SOC scores of patients diagnosed with celiac disease (CD) and matched healthy controls to investigate possible correlations between low SOC scores and CD. Patients and Methods: Patients provided demographic data and completed the 13-item SOC questionnaire. Patients in the study cohort were matched to healthy controls according to age, gender, education, income, employment status and marital status. Results: A total of 239 CD patients and 124 healthy controls answered the SOC questionnaire. Among them,124 patients were matched to the healthy cohort according to propensity score. CD patients had a median SOC score of 57 (IQR 52.25-62), and controls 65.5 (IQR 57-75) pConclusions: SOC reflects a person's resources and orientation which enable individuals to cope with stressors in a way that promotes health. Lower SOC score is correlated with the development of CD.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"6 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85233735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Causing Factors of Sociology Food: Eating Disorder 社会学食物进食障碍成因综述
Pub Date : 2020-04-27 DOI: 10.12691/IJCD-8-1-2
L. Sarvananda
Eating disorders are also symbolic of sociology food. It represents how control eating disorders do not limit to anorexia. These disorders include bulimia and binge eating as well. Some people often use food as a comfort, or negative thing to avoid, even though if necessary survival. The relationships between food and people are very large complex; still, the causes of the eating disorder are unclear, death of eating disorders about 7,000 deaths in the year of 2010, due to the mental illnesses with the highest mortality rate. These disorders show the psychological relationships between people and food and view it as harmful. And focus on the physical air of themselves as opposed to could do with food for energy and diet. This fixed with crushing sexuality in the media. According to media, Girls, young women, and even men making them turn to desperate measures with these eating disorders. Here discussed many scenarios to cause eating disorders such as environmental, social and interpersonal issues that could promote and sustain these illnesses also, the media are oftentimes blamed for the rise in the incidence of eating disorders. Furthermore, should develop the finest strategies to control the risk of eating disorders and suggests avoiding media when wondering about body health.
饮食失调也是社会学食物的象征。它代表了如何控制饮食失调并不局限于厌食症。这些疾病包括贪食症和暴饮暴食。有些人经常把食物作为一种安慰,或者是避免负面的东西,即使是必要的生存。食物和人之间的关系非常复杂;尽管如此,导致饮食失调的原因尚不清楚,2010年约有7000人死于饮食失调,因精神疾病而死亡率最高。这些疾病显示了人与食物之间的心理关系,并将其视为有害的。把注意力集中在自己的身体上,而不是通过食物来获取能量和饮食。这与媒体对性的大肆渲染有关。据媒体报道,女孩、年轻女性,甚至男性,都让他们对这些饮食失调症采取了绝望的措施。这里讨论了许多导致饮食失调的情况,如环境,社会和人际关系问题,这些问题可能会促进和维持这些疾病,媒体经常被指责为饮食失调发病率的上升。此外,应该制定最好的策略来控制饮食失调的风险,并建议在担心身体健康时避免媒体。
{"title":"A Review of Causing Factors of Sociology Food: Eating Disorder","authors":"L. Sarvananda","doi":"10.12691/IJCD-8-1-2","DOIUrl":"https://doi.org/10.12691/IJCD-8-1-2","url":null,"abstract":"Eating disorders are also symbolic of sociology food. It represents how control eating disorders do not limit to anorexia. These disorders include bulimia and binge eating as well. Some people often use food as a comfort, or negative thing to avoid, even though if necessary survival. The relationships between food and people are very large complex; still, the causes of the eating disorder are unclear, death of eating disorders about 7,000 deaths in the year of 2010, due to the mental illnesses with the highest mortality rate. These disorders show the psychological relationships between people and food and view it as harmful. And focus on the physical air of themselves as opposed to could do with food for energy and diet. This fixed with crushing sexuality in the media. According to media, Girls, young women, and even men making them turn to desperate measures with these eating disorders. Here discussed many scenarios to cause eating disorders such as environmental, social and interpersonal issues that could promote and sustain these illnesses also, the media are oftentimes blamed for the rise in the incidence of eating disorders. Furthermore, should develop the finest strategies to control the risk of eating disorders and suggests avoiding media when wondering about body health.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"20 1","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2020-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79055296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Olmesartan-Induced Collagenous Sprue 奥美沙坦诱导的胶原性口疮
Pub Date : 2020-04-27 DOI: 10.12691/IJCD-8-1-6
H. Freeman
A 65-yr-old female with diarrhea for 3 months and weight loss was evaluated. There was no travel or family history, but she had been treated with olmesartan for an elevated blood pressure. Fecal studies for an infectious cause were negative and serological studies for celiac disease were negative. A small bowel biopsy showed changes of collagenous sprue. The drug was discontinued. Diarrhea ceased and she regained her weight. Repeat biopsies of the small bowel were normal. Except for cessation of the olmesartan, no other dietary (eg., gluten-free diet) or treatment medication (eg., steroids) was provided. Long-term follow-up revealed no recurrence of symptoms in patients with sprue-like intestinal disease or collagenous sprue, consideration should be given to a drug-induced cause. This may limit the need for further clinical studies, restrictive diets or powerful prescribed medications, including steroids and immunosuppressive agents.
65岁女性,腹泻3个月,体重下降。她没有旅行史,也没有家族史,但她曾因血压升高而接受奥美沙坦治疗。粪便感染原因研究为阴性,乳糜泻血清学研究为阴性。小肠活检显示胶原口改变。该药已停药。腹泻停止了,她的体重也恢复了。小肠重复活检正常。除停止服用奥美沙坦外,没有其他饮食(如:(如无麸质饮食)或治疗药物(如;(类固醇)。长期随访发现,豆芽样肠道疾病或胶原性豆芽均无症状复发,应考虑药物引起的原因。这可能限制了进一步临床研究、限制性饮食或强效处方药(包括类固醇和免疫抑制剂)的需要。
{"title":"Olmesartan-Induced Collagenous Sprue","authors":"H. Freeman","doi":"10.12691/IJCD-8-1-6","DOIUrl":"https://doi.org/10.12691/IJCD-8-1-6","url":null,"abstract":"A 65-yr-old female with diarrhea for 3 months and weight loss was evaluated. There was no travel or family history, but she had been treated with olmesartan for an elevated blood pressure. Fecal studies for an infectious cause were negative and serological studies for celiac disease were negative. A small bowel biopsy showed changes of collagenous sprue. The drug was discontinued. Diarrhea ceased and she regained her weight. Repeat biopsies of the small bowel were normal. Except for cessation of the olmesartan, no other dietary (eg., gluten-free diet) or treatment medication (eg., steroids) was provided. Long-term follow-up revealed no recurrence of symptoms in patients with sprue-like intestinal disease or collagenous sprue, consideration should be given to a drug-induced cause. This may limit the need for further clinical studies, restrictive diets or powerful prescribed medications, including steroids and immunosuppressive agents.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"22 1","pages":"32-34"},"PeriodicalIF":0.0,"publicationDate":"2020-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82420923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Sprue-like Intestinal Disease Induced by Checkpoint Inhibitor Immunotherapy 检查点抑制剂免疫治疗诱导的芽孢样肠道疾病
Pub Date : 2020-04-27 DOI: 10.12691/IJCD-8-1-5
H. Freeman
In recent years, immune checkpoint inhibitors have been increasingly used in cancer treatment with significant improvements in overall survival. A downside of these agents has been the emergence of novel intestinal diseases as reflected by development of diarrhea, sometimes severe, in at least 10%. In some, an immune-mediated enterocolitis may often develop. This may be severe, difficult to manage and result in a fatal outcome. Less well appreciated, however, are other less commonly detected forms of colitis, such as collagenous colitis, along with small bowel changes, specifically, sprue-like intestinal disease, apparently occurring as an independent inflammatory process. Taken together, these are likely to represent different pathological phenotypic expressions of treatment toxicity in the intestinal tract following management of cancer with checkpoint inhibitors.
近年来,免疫检查点抑制剂越来越多地用于癌症治疗,并显著提高了总生存率。这些药物的一个缺点是出现了新的肠道疾病,表现为腹泻的发展,有时严重,至少有10%。在某些情况下,免疫介导的小肠结肠炎可能经常发生。这可能很严重,难以控制,并导致致命的后果。然而,其他不太常见的结肠炎形式,如胶原性结肠炎,伴随着小肠变化,特别是芽状肠道疾病,显然是作为一个独立的炎症过程发生的。综上所述,这些可能代表了使用检查点抑制剂治疗癌症后肠道治疗毒性的不同病理表型表达。
{"title":"Sprue-like Intestinal Disease Induced by Checkpoint Inhibitor Immunotherapy","authors":"H. Freeman","doi":"10.12691/IJCD-8-1-5","DOIUrl":"https://doi.org/10.12691/IJCD-8-1-5","url":null,"abstract":"In recent years, immune checkpoint inhibitors have been increasingly used in cancer treatment with significant improvements in overall survival. A downside of these agents has been the emergence of novel intestinal diseases as reflected by development of diarrhea, sometimes severe, in at least 10%. In some, an immune-mediated enterocolitis may often develop. This may be severe, difficult to manage and result in a fatal outcome. Less well appreciated, however, are other less commonly detected forms of colitis, such as collagenous colitis, along with small bowel changes, specifically, sprue-like intestinal disease, apparently occurring as an independent inflammatory process. Taken together, these are likely to represent different pathological phenotypic expressions of treatment toxicity in the intestinal tract following management of cancer with checkpoint inhibitors.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"27 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2020-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83557112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
International Journal of Celiac Disease
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1