E. Duca, G. Sur, Teodora-Maria Zahariuc, G. Maak, L. Sur
Both the inborn and acquired immune system plays an important role in the pathogenicity of atopic dermatitis (AD). The skin lesions are mostly due to the complex interaction of the cytokines, above all the ones secreted by the T helper 2 lymphocytes (Th2). In the acute phase of the disease, the most important cytokines are IL-4, IL-5 and IL-13, and also the subsequent activation of mastocytes and eosinophiles. The next step is the production of antigen-specific antibodies. The Th2 immune response is initiated by IL-1, IL-25, IL-17, IL-33 and by thymic stromal lymphopoietin (TSLP). Th2 cytokines block the expression of differentiation of certain proteins, like locrine, filaggrin, involucrin, and at the same time, they reduce the beta-antimicrobial peptide levels, disturbing the skin barrier in the process. In the chronic phase of the illness, the Th2 cytokines are predominant, with varying levels of T helper 17 cytokines.
{"title":"Immunological Implications in Atopic Dermatitis","authors":"E. Duca, G. Sur, Teodora-Maria Zahariuc, G. Maak, L. Sur","doi":"10.12691/IJCD-9-2-8","DOIUrl":"https://doi.org/10.12691/IJCD-9-2-8","url":null,"abstract":"Both the inborn and acquired immune system plays an important role in the pathogenicity of atopic dermatitis (AD). The skin lesions are mostly due to the complex interaction of the cytokines, above all the ones secreted by the T helper 2 lymphocytes (Th2). In the acute phase of the disease, the most important cytokines are IL-4, IL-5 and IL-13, and also the subsequent activation of mastocytes and eosinophiles. The next step is the production of antigen-specific antibodies. The Th2 immune response is initiated by IL-1, IL-25, IL-17, IL-33 and by thymic stromal lymphopoietin (TSLP). Th2 cytokines block the expression of differentiation of certain proteins, like locrine, filaggrin, involucrin, and at the same time, they reduce the beta-antimicrobial peptide levels, disturbing the skin barrier in the process. In the chronic phase of the illness, the Th2 cytokines are predominant, with varying levels of T helper 17 cytokines.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83872021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 43-yr old female with two prior renal transplants for renal failure associated with diabetes, retinopathy and coronary artery disease developed diarrhea. Her medications included mycophenolate mofetil, an immunosuppressive medication documented to cause sprue-like mucosal changes in the small intestine. Later studies revealed a small intestinal mucosal lesion characterized by marked crypt hyperplasia, villous atrophy and increased intra-epithelial lymphocytes. Serological studies for celiac disease were negative and repeated biopsies despite a strict gluten-free diet, revealed histopathological persistence of a severely abnormal sprue-like enteropathy. Eventually, further biopsies of her small intestine revealed superimposed changes characterized by dense sub-epithelial collagen deposits histochemically staining positive for trichrome, typical of collagenous sprue and representing an expansion of published pathological features of mycophenolate-associated small intestinal mucosal disease.
{"title":"Mycophenolate-Associated Sprue-Like Intestinal Disease Evolving into Collagenous Sprue","authors":"H. Freeman, M. Nimmo","doi":"10.12691/IJCD-9-2-5","DOIUrl":"https://doi.org/10.12691/IJCD-9-2-5","url":null,"abstract":"A 43-yr old female with two prior renal transplants for renal failure associated with diabetes, retinopathy and coronary artery disease developed diarrhea. Her medications included mycophenolate mofetil, an immunosuppressive medication documented to cause sprue-like mucosal changes in the small intestine. Later studies revealed a small intestinal mucosal lesion characterized by marked crypt hyperplasia, villous atrophy and increased intra-epithelial lymphocytes. Serological studies for celiac disease were negative and repeated biopsies despite a strict gluten-free diet, revealed histopathological persistence of a severely abnormal sprue-like enteropathy. Eventually, further biopsies of her small intestine revealed superimposed changes characterized by dense sub-epithelial collagen deposits histochemically staining positive for trichrome, typical of collagenous sprue and representing an expansion of published pathological features of mycophenolate-associated small intestinal mucosal disease.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89887036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-31DOI: 10.5772/INTECHOPEN.95837
F. Gualandris, L. Castellani, A. Falanga
DQ2 is a surface receptor of class II MHC exposed on APC immune-competent cells. Its function is to recognize non-self-antigens and present them to CD4+ T-helper lymphocytes, which activate cytokine <21> production and control antibody production and cell response. The activation of T lymphocytes by peptides derived from gluten proteins and the production of antibodies directed against tTG in tissues where it is localized is the basis of the etiopathogenesis of celiac disease (CD). CD is frequently associated with the presence of specific HLA system genes encoding heterodimers DQ2 and DQ8, identifiable by the DQA1*0501/DQB1*0201 or DQA1*0501/DQB1*0202 and DQB1*0302 alleles. DQ2 is also associated with genetic, endocrinological and neurological diseases such as: type 1 diabetes, thyroiditis, pancreatitis and multiple sclerosis. Interactions between DQ2 and T lymphoma have also been demonstrated. The correlation between autoimmune diseases in patients with CD and therefore DQ2 is much more frequent than in healthy subjects.
{"title":"The Association of HLA-DQ2 with Celiac Disease","authors":"F. Gualandris, L. Castellani, A. Falanga","doi":"10.5772/INTECHOPEN.95837","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.95837","url":null,"abstract":"DQ2 is a surface receptor of class II MHC exposed on APC immune-competent cells. Its function is to recognize non-self-antigens and present them to CD4+ T-helper lymphocytes, which activate cytokine <21> production and control antibody production and cell response. The activation of T lymphocytes by peptides derived from gluten proteins and the production of antibodies directed against tTG in tissues where it is localized is the basis of the etiopathogenesis of celiac disease (CD). CD is frequently associated with the presence of specific HLA system genes encoding heterodimers DQ2 and DQ8, identifiable by the DQA1*0501/DQB1*0201 or DQA1*0501/DQB1*0202 and DQB1*0302 alleles. DQ2 is also associated with genetic, endocrinological and neurological diseases such as: type 1 diabetes, thyroiditis, pancreatitis and multiple sclerosis. Interactions between DQ2 and T lymphoma have also been demonstrated. The correlation between autoimmune diseases in patients with CD and therefore DQ2 is much more frequent than in healthy subjects.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84323015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
SARS-CoV-2, the virus that causes COVID-19, impacts human health all over the world with high morbidity and mortality. Many chronic diseases predispose the patients to be infected, including autoimmune diseases. Despite theoretical and rare exceptions, celiac disease is not a high-risk condition for COVID-19 infection. The present review expends on those potential circumstances that put the CD patients at risk for COVID-19.
{"title":"The COVID-19 Vaccination Debate: CoV-2 in Celiac Disease: A Pathogen or just along for the Ride?","authors":"A. Lerner","doi":"10.12691/IJCD-9-1-8","DOIUrl":"https://doi.org/10.12691/IJCD-9-1-8","url":null,"abstract":"SARS-CoV-2, the virus that causes COVID-19, impacts human health all over the world with high morbidity and mortality. Many chronic diseases predispose the patients to be infected, including autoimmune diseases. Despite theoretical and rare exceptions, celiac disease is not a high-risk condition for COVID-19 infection. The present review expends on those potential circumstances that put the CD patients at risk for COVID-19.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"19 1","pages":"6-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75206633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enzyme therapy as a management tool for patients with celiac disease (CD) or gluten intolerance is gaining acceptance around the world. Gluten has multiple side effects and limitations of a gluten-free diet (GFD) in management of CD are evident and mainly related to the presence of hidden gluten or cross-contamination of meals in restaurants. The present paper discusses enzyme therapy with caricain, namely Gluteguard, in light of various approaches searching for a treatment or an effective management of CD. Regular users of the supplement Gluteguard report a high level of satisfaction with the product. This indicates that enzyme therapy based on caricain has its place as a safeguard when the gluten-free meals are prepared outside the control of the patients.
{"title":"Enzyme Therapy for Patients with Celiac Disease - An Update","authors":"H. Cornell, T. Stelmasiak, A. Lerner","doi":"10.12691/IJCD-9-1-1","DOIUrl":"https://doi.org/10.12691/IJCD-9-1-1","url":null,"abstract":"Enzyme therapy as a management tool for patients with celiac disease (CD) or gluten intolerance is gaining acceptance around the world. Gluten has multiple side effects and limitations of a gluten-free diet (GFD) in management of CD are evident and mainly related to the presence of hidden gluten or cross-contamination of meals in restaurants. The present paper discusses enzyme therapy with caricain, namely Gluteguard, in light of various approaches searching for a treatment or an effective management of CD. Regular users of the supplement Gluteguard report a high level of satisfaction with the product. This indicates that enzyme therapy based on caricain has its place as a safeguard when the gluten-free meals are prepared outside the control of the patients.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"5 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2021-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84203260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Celiac disease has been recognized as a multisystem immunological disorder commonly manifested in children and adults. Celiac disease is a common syndrome which is usually efficiently treated with a gluten-free diet as well as an optimal prognosis. Some major symptoms of celiac disease include malabsorption syndrome which could manifest in the form of chronic diarrhea, weight loss, and abdominal distention. COVID-19 have been observed to impact and worsen several disorders and lifestyle habits but have been found to not affect patients with autoimmune diseases such as celiac disease. This article would serve as a foundation for further research on the impact of COVID-19 on celiac disease.
{"title":"The COVID-19 Vaccination Debate: Is there is a Link between COVID-19 and Celiac Disease?","authors":"M. O. F. Barriguete, M. Okorie","doi":"10.12691/IJCD-9-1-5","DOIUrl":"https://doi.org/10.12691/IJCD-9-1-5","url":null,"abstract":"Celiac disease has been recognized as a multisystem immunological disorder commonly manifested in children and adults. Celiac disease is a common syndrome which is usually efficiently treated with a gluten-free diet as well as an optimal prognosis. Some major symptoms of celiac disease include malabsorption syndrome which could manifest in the form of chronic diarrhea, weight loss, and abdominal distention. COVID-19 have been observed to impact and worsen several disorders and lifestyle habits but have been found to not affect patients with autoimmune diseases such as celiac disease. This article would serve as a foundation for further research on the impact of COVID-19 on celiac disease.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"24 1","pages":"10-11"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81400489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chemical pollution of water is the contamination of water by foreign matter that deteriorates the quality of the water. Pollution of water by heavy metals are dangerous because they tend to cause Bioaccumulation that means an increase in the concentration of a chemical in a biological organism over time, compared to the chemical's concentration in the environment. Chemical pollution of Manzala lake was studied in 4 main localities, Kapoty, Bashtier, Mataryia and Gamil areas which receives high load of sewage, agricultural and industrial wastes from different sources. Heavy metals, such as Zn, Pb, Cd and Hg were estimated in water and fish samples, to reveal high pollution of lake Manzala with such toxic elements, where Zn, reached 800µg/L. Pb,195 µg/L. Cd 45 µg/L and. Hg, 5000 µg/L in water samples.
{"title":"For Patients with Celiac Disease: Pay Attention to Polluted Seafood","authors":"M. Zaky, S. M. E. Toubar, A. El-Shafey","doi":"10.12691/IJCD-9-1-2","DOIUrl":"https://doi.org/10.12691/IJCD-9-1-2","url":null,"abstract":"Chemical pollution of water is the contamination of water by foreign matter that deteriorates the quality of the water. Pollution of water by heavy metals are dangerous because they tend to cause Bioaccumulation that means an increase in the concentration of a chemical in a biological organism over time, compared to the chemical's concentration in the environment. Chemical pollution of Manzala lake was studied in 4 main localities, Kapoty, Bashtier, Mataryia and Gamil areas which receives high load of sewage, agricultural and industrial wastes from different sources. Heavy metals, such as Zn, Pb, Cd and Hg were estimated in water and fish samples, to reveal high pollution of lake Manzala with such toxic elements, where Zn, reached 800µg/L. Pb,195 µg/L. Cd 45 µg/L and. Hg, 5000 µg/L in water samples.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"1 1","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91215659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Biliary atresia is commonly associated with malnutrition and failure to thrive. Very few studies have been published on the impact of preoperative malnutrition on post-transplant outcomes in these children. Material and Methods: 110 children underwent living donor liver transplantation from January 2003 to March 2013. Pre-transplant malnutrition was defined according to z scores for the weight for age and height for age as per who definition. Patients having both Z score of < -2 were compared with the control group. Statistical analysis was done using SPSS version 21 (IBM). Results: 39 children out of 110 were having z score for the weight for age < -2. There was no statistical difference between PELD score, graft weight, GRWR, intraoperative blood loss between to groups. 22 out of 39 patients in malnourished group developed clavein grade 3, grade 4 complications and 32 patients out of 71 in the control group developed clavien grade 3 grade 4 complications. (p= 0.318). The overall mortality rate was 4.5% and mortality rates in the malnourished vs control group were respectively 7.69% and 2.81% (p= 0.278). A total of 14 patients developed postoperative pulmonary complications. Pulmonary complications were significantly high in the malnourished group. p=0.003. Conclusion: Preoperative malnutrition is associated with a high postoperative pulmonary complication rate in liver transplantation for biliary atresia.
{"title":"In a Time of Pandemic: Predictors for Post-transplant Respiratory Complications","authors":"B. Vasavada","doi":"10.12691/IJCD-9-1-4","DOIUrl":"https://doi.org/10.12691/IJCD-9-1-4","url":null,"abstract":"Introduction: Biliary atresia is commonly associated with malnutrition and failure to thrive. Very few studies have been published on the impact of preoperative malnutrition on post-transplant outcomes in these children. Material and Methods: 110 children underwent living donor liver transplantation from January 2003 to March 2013. Pre-transplant malnutrition was defined according to z scores for the weight for age and height for age as per who definition. Patients having both Z score of < -2 were compared with the control group. Statistical analysis was done using SPSS version 21 (IBM). Results: 39 children out of 110 were having z score for the weight for age < -2. There was no statistical difference between PELD score, graft weight, GRWR, intraoperative blood loss between to groups. 22 out of 39 patients in malnourished group developed clavein grade 3, grade 4 complications and 32 patients out of 71 in the control group developed clavien grade 3 grade 4 complications. (p= 0.318). The overall mortality rate was 4.5% and mortality rates in the malnourished vs control group were respectively 7.69% and 2.81% (p= 0.278). A total of 14 patients developed postoperative pulmonary complications. Pulmonary complications were significantly high in the malnourished group. p=0.003. Conclusion: Preoperative malnutrition is associated with a high postoperative pulmonary complication rate in liver transplantation for biliary atresia.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"52 1","pages":"12-15"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73561514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
More and more patients with celiac disease are asking us “Should I be vaccinated against COVID-19, or not? What to do?” These are unknown things, we live in new times. What we can do is gather information and present it to you in the following. My colleagues, Professor Hugh James Freeman and Professor Aaron Lerner will give you answers in 2 articles of high academic level “COVID-19 AND CELIAC DISEASE” and “COV-2 IN CELIAC DISEASE: A PATHOGEN OR JUST ALONG FOR THE RIDE?”, which I invite you to read. We have also a nice article “IS THERE IS A LINK BETWEEN COVID-19 AND CELIAC DISEASE?” from USA. As Editor-in-chief, I will present you official information from official websites.
{"title":"The COVID-19 Vaccination Debate: Should Patients with Celiac Disease be Vaccinated with COVID-19 Vaccine?","authors":"G. Samașca","doi":"10.12691/IJCD-9-1-6","DOIUrl":"https://doi.org/10.12691/IJCD-9-1-6","url":null,"abstract":"More and more patients with celiac disease are asking us “Should I be vaccinated against COVID-19, or not? What to do?” These are unknown things, we live in new times. What we can do is gather information and present it to you in the following. My colleagues, Professor Hugh James Freeman and Professor Aaron Lerner will give you answers in 2 articles of high academic level “COVID-19 AND CELIAC DISEASE” and “COV-2 IN CELIAC DISEASE: A PATHOGEN OR JUST ALONG FOR THE RIDE?”, which I invite you to read. We have also a nice article “IS THERE IS A LINK BETWEEN COVID-19 AND CELIAC DISEASE?” from USA. As Editor-in-chief, I will present you official information from official websites.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"100 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76062968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
COVID-19 is a novel coronavirus that appears to cause a systemic disorder largely marked by fever and respiratory symptoms as well as diarrhea. The agent gains access to respiratory and gastrointestinal cells through a complex molecular mechanism associated with increased ACE2 receptor expression on brush border membranes of epithelial cells. Because some autoimmune-based disorders, including celiac disease, appear to be at increased risk for viral and community-acquired bacterial infections, a number of preliminary survey studies from different countries, largely web-based or telephone-based, have suggested that COVID-19 infection risk is not increased in celiac disease. However, specific sub-groups of patients with celiac disease have not been thoroughly evaluated. For example, selective immunoglobulin A deficiency or other immune deficiency states with celiac disease may represent a special risk group for COVID-19 and other viral infectious agents.
{"title":"The COVID-19 Vaccination Debate: COVID-19 and Celiac Disease","authors":"H. Freeman","doi":"10.12691/IJCD-9-1-7","DOIUrl":"https://doi.org/10.12691/IJCD-9-1-7","url":null,"abstract":"COVID-19 is a novel coronavirus that appears to cause a systemic disorder largely marked by fever and respiratory symptoms as well as diarrhea. The agent gains access to respiratory and gastrointestinal cells through a complex molecular mechanism associated with increased ACE2 receptor expression on brush border membranes of epithelial cells. Because some autoimmune-based disorders, including celiac disease, appear to be at increased risk for viral and community-acquired bacterial infections, a number of preliminary survey studies from different countries, largely web-based or telephone-based, have suggested that COVID-19 infection risk is not increased in celiac disease. However, specific sub-groups of patients with celiac disease have not been thoroughly evaluated. For example, selective immunoglobulin A deficiency or other immune deficiency states with celiac disease may represent a special risk group for COVID-19 and other viral infectious agents.","PeriodicalId":13927,"journal":{"name":"International Journal of Celiac Disease","volume":"9 1","pages":"3-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83889197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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