International journal of hygiene and environmental health最新文献_第2页

Prenatal ambient heat exposure and neurodevelopment: A scoping review of human and animal research 产前环境热暴露和神经发育：人类和动物研究的范围综述

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-13 DOI: 10.1016/j.ijheh.2026.114741

Amina Rhaman , Danielle J. Russell , Leaf R. Kardol , Ebony Quintrell , Shannon Morgan , Candra Maung , Azmain Talukder , Aster Gebremedhin , Stephanie Tan , Ramya Padmavathy Radha Krishnan , Erin Kelty , Caitlin Wyrwoll

Background

Ambient heat exposure during pregnancy is associated with adverse outcomes, and adverse neurodevelopmental outcomes are an emerging concern. This scoping review synthesises human and animal evidence on the association between prenatal ambient heat exposure and poor neurodevelopmental outcomes.

Methods

A search was conducted across MEDLINE, Global Health, Web of Science, PsycINFO, and CINAHL. Studies up until May 2025, examining prenatal ambient heat exposure and neurodevelopmental outcomes such as congenital malformations and mental health conditions, were included. Two reviewers independently screened and extracted in duplicate using Covidence. Studies were categorised based on short-term or long-term outcomes.

Results

The search yielded 8189 studies, with 58 meeting the inclusion criteria (17 human, 41 animal). Animal evidence was primarily based on rodents (n = 32) exposed to extreme heat that caused hyperthermia. Human studies were methodologically diverse, yielding inconsistent results. There was robust evidence to suggest an increased risk of central nervous system (CNS) malformations and a reduction in brain weight in animal studies. However, evidence from the small number of human studies was inconclusive. For long-term outcomes, such as mental health (n = 11), both human and animal studies were limited but generally reported adverse outcomes.

Conclusion

Overall, the evidence suggests a potential link between prenatal heat exposure, CNS malformations and altered brain size in animal models; however, the implications for humans remain uncertain. Human studies were scarce and inconsistent in their approaches. Future animal studies should employ realistic heat exposures to improve human applicability, and human studies should utilise consistent outcomes and exposure measures.

背景：妊娠期环境热暴露与不良后果有关，不良的神经发育后果是一个新出现的问题。本综述综合了产前环境热暴露与不良神经发育结果之间的关联的人类和动物证据。方法检索MEDLINE、Global Health、Web of Science、PsycINFO和CINAHL。截至2025年5月的研究包括了产前环境热暴露和神经发育结果，如先天性畸形和精神健康状况。两名审稿人独立筛选并使用covid - ence进行重复提取。研究根据短期或长期结果进行分类。结果共检索到8189项研究，其中58项符合纳入标准（17人，41动物）。动物证据主要是基于暴露在导致高热的极端高温下的啮齿动物（n = 32）。人体研究方法多样，结果不一致。有有力的证据表明，在动物研究中，中枢神经系统（CNS）畸形的风险增加，脑重量减少。然而，来自少量人体研究的证据尚无定论。对于长期结果，如心理健康（n = 11），人类和动物研究都很有限，但通常报告了不良结果。总之，有证据表明，在动物模型中，产前热暴露、中枢神经系统畸形和脑大小改变之间存在潜在联系；然而，对人类的影响仍不确定。人体研究很少，方法也不一致。未来的动物研究应该采用真实的热暴露来提高人类的适用性，人类研究应该利用一致的结果和暴露措施。

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引用次数: 0

Maternal serum polybrominated diphenyl ether concentrations during pregnancy and adolescent bone mineral density at age 12 years 妊娠期间母体血清多溴联苯醚浓度与12岁青少年骨密度

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-13 DOI: 10.1016/j.ijheh.2026.114742

Katherine M. Marquess , Jordan R. Kuiper , Bruce P. Lanphear , Antonia M. Calafat , Andreas Sjodin , Maria Ospina , Lesliam Quirós-Alcalá , Kim M. Cecil , Halley Wasserman , Yingying Xu , Kimberly Yolton , Heidi J. Kalkwarf , Joseph M. Braun , Aimin Chen , Jessie P. Buckley

Polybrominated diphenyl ethers (PBDEs), used as chemical flame retardants, are developmental osteotoxicants in mechanistic studies, but the effects of in utero exposure on adolescent bone health are unknown. We examined associations of gestational serum PBDE concentrations and BMD Z-scores in adolescence. Among 184 mother-adolescent pairs enrolled in the Health Outcomes and Measures of the Environment Study (Cincinnati, OH: 2003–2006), we quantified five PBDEs in maternal serum and four organophosphate ester (OPE) metabolites in maternal urine collected at 16- or 26-weeks gestation. At age 12 years, we conducted dual energy x-ray absorptiometry scans and calculated bone mineral density (BMD) Z-scores for six skeletal sites. We estimated covariate-adjusted associations per log₁₀ increase in maternal serum PBDE concentrations using linear regression and assessed effect measure modification (EMM) by adolescent's sex using interaction terms. We also examined PBDE and OPE mixtures using quantile-based g-computation. In adjusted models, BDE-153 concentrations were associated with lower femoral neck BMD (β: −0.42; 95 % CI: −0.79, −0.05). Results were similar but weaker for other individual PBDEs and their mixture. The associations of BDEs-28, -47, and -100 with hip and femoral neck BMD Z-score were modified by adolescent's sex. For example, log₁₀ BDE-28 was associated with total hip BMD Z-score differences of −0.75 (95 % CI: −1.50, 0.01) for males and 0.21 (95 % CI: −0.31, 0.74) for females (EMM p = 0.04). Higher quartiles of the PBDE + OPE mixture showed weak, site-specific associations with BMD, though all CIs crossed the null. In utero PBDE exposure may negatively affect adolescent bone health.

作为化学阻燃剂的多溴联苯醚（PBDEs）在机理研究中是发育性骨毒性物质，但子宫内暴露对青少年骨骼健康的影响尚不清楚。我们研究了妊娠期血清多溴二苯醚浓度与青春期BMD z -评分之间的关系。在184对纳入健康结果和环境测量研究（俄亥俄州辛辛那提：2003-2006）的母亲-青少年对中，我们量化了在妊娠16或26周收集的母亲血清中的五种多溴二苯醚和母亲尿液中的四种有机磷酯（OPE）代谢物。在12岁时，我们进行了双能x线吸收仪扫描并计算了六个骨骼部位的骨矿物质密度（BMD） z分数。我们使用线性回归估计了每增加log10的母体血清多溴二苯醚浓度的协变量调整关联，并使用交互作用项评估了青少年性别的效应测量修正（EMM）。我们还使用基于分位数的g计算检查了PBDE和OPE混合物。在调整后的模型中，BDE-153浓度与股骨颈下部骨密度相关（β: - 0.42; 95% CI: - 0.79, - 0.05）。结果相似，但较弱的其他个体多溴二苯醚及其混合物。BDEs-28、-47、-100与髋、股骨颈BMD Z-score的相关性受青少年性别影响。例如，log10 BDE-28与男性髋部总BMD Z-score差异的相关性为- 0.75 (95% CI: - 1.50, 0.01)，女性为0.21 (95% CI: - 0.31, 0.74) （EMM p = 0.04）。PBDE + OPE混合物的高四分位数与BMD表现出微弱的、位点特异性的关联，尽管所有ci都越过了null。在子宫内接触多溴二苯醚可能对青少年骨骼健康产生负面影响。

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引用次数: 0

Urinary cotinine cut-offs for tobacco smoke exposure in pregnancy and associations with child intelligence quotient: A multi-cohort analysis 妊娠期暴露于烟草烟雾中的尿可替宁临界值与儿童智商的关系：一项多队列分析

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2026-01-10 DOI: 10.1016/j.ijheh.2026.114744

Yu Ni , Logan C. Dearborn , Adam A. Szpiro , Christine T. Loftus , Qi Zhao , Nicole R. Bush , Kaja Z. LeWinn , Marnie F. Hazlehurst , Thomas F. Northrup , Penelope J.E. Quintana , Eunha Hoh , Georg Matt , Catherine J. Karr

Background

Prenatal exposure to tobacco smoke may impair neurodevelopment in children. However, accurately characterizing this exposure remains challenging.

Methods

We pursued two objectives in this large population study. First, in 1708 pregnant women from the Environmental Influences on Child Health Outcomes (ECHO) cohort, we constructed Receiver Operating Characteristic (ROC) curves to determine urinary cotinine cut-offs to classify firsthand (FHS), environmental (ETS), and no exposure, and further distinguished secondhand (SHS) from thirdhand smoke (THS) exposure within ETS. Second, among 1593 participants in three pregnancy cohorts nested in ECHO, we fit multivariable linear regressions to examine the association between the newly defined smoke exposures and child full-scale intelligence quotient (IQ) at age 4–6 years, and to assess potential effect modification by maternal education or neighborhood deprivation.

Results

Optimal cotinine cut-offs were 17.74 ng/mL and 0.44 ng/mL to discriminate FHS and no exposure, respectively. Among the ETS group, a cut-off of 5.69 ng/mL differentiated SHS from THS. Applying these optimal cut-offs, we estimated a 0.93-point (95 %CI: 3.44, 1.59) and a 1.03-point (95 %CI: 2.84, 0.79) lower child IQ in the FHS and ETS categories, respectively, compared to no exposure. The inverse association between prenatal ETS and child IQ was mainly driven by SHS. Stronger associations were suggested in subgroups with higher education attainment or those living in less deprived neighborhoods.

Conclusions

This study provides a novel classification of prenatal tobacco smoke exposures. Although the associations with child IQ were statistically insignificant, the study carries important implications for future research on developmental origins of diseases.

产前接触烟草烟雾可能损害儿童的神经发育。然而，准确地描述这种暴露仍然具有挑战性。方法在这项大规模人群研究中，我们追求两个目标。首先，在来自环境影响儿童健康结局（ECHO）队列的1708名孕妇中，我们构建了受试者工作特征（ROC）曲线来确定尿可替宁的截止值，以分类第一手（FHS）、环境（ETS）和无暴露，并进一步区分ETS中的二手（SHS）和三手烟（THS）暴露。其次，在ECHO中嵌套的三个妊娠队列的1593名参与者中，我们拟合多变量线性回归来检验新定义的烟雾暴露与4-6岁儿童全面智商（IQ）之间的关系，并评估母亲教育或邻里剥夺的潜在影响。结果可替宁的最佳临界值分别为17.74 ng/mL和0.44 ng/mL。在ETS组中，将SHS与THS区分开来的截止值为5.69 ng/mL。应用这些最佳截断值，我们估计与没有暴露相比，FHS和ETS类别的儿童智商分别降低0.93点（95% CI: 3.44, 1.59）和1.03点（95% CI: 2.84, 0.79）。产前ETS与儿童智商呈负相关，主要由SHS驱动。在受教育程度较高或生活在较贫困社区的亚组中，这种关联更强。结论本研究提供了一种新的产前烟草烟雾暴露分类方法。虽然与儿童智商的关联在统计上不显著，但这项研究对未来研究疾病的发育起源具有重要意义。

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引用次数: 0

Perinatal environmental exposures, maternal mental health and cognitive outcomes in very preterm infants born in urban London 围产期环境暴露，孕产妇心理健康和认知结果在伦敦城市出生的极早产儿。

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-27 DOI: 10.1016/j.ijheh.2025.114740

Zeyuan Sun , Kaili Liang , Andrew Lawrence , Marguerite Leoni , Serena J. Counsell , Paola Dazzan , A David Edwards , Chiara Nosarti

Introduction

Very preterm (VPT) infants face elevated neurodevelopmental risks. The impact of perinatal environmental exposures, where complex factors may affect maternal mental health and infant outcomes, remains poorly understood. This study examines how joint environmental exposures relate to postnatal maternal anxiety and neurodevelopment in VPT infants.

Methods

We included 427 VPT infants born in Greater London (2010–2013). We derived residential environmental exposures: air pollutants, noise, and open space. Clustering analysis identified exposure profiles. At term-equivalent age (38–44 weeks), infants underwent T2-weighted MRI for brain volume and cortical feature analysis. Maternal anxiety, assessed at term; neurodevelopment, evaluated at 18–24 months; and brain development were compared between exposure clusters, adjusting for socioeconomic status (SES). We further explored the role of SES in environmental exposure.

Results

Three exposure profiles emerged. Compared to Group 1 (reference; n = 358), Group 2 (n = 42), characterised by poor air quality and limited open space, had a higher risk of cognitive delay and greater socioeconomic disadvantage. Conversely, Group 3 (n = 27; low noise exposure) exhibited reduced maternal anxiety. SES contributed 20.91 % of the environmental effect on cognitive delay. No significant differences in brain volumes or cortical features were observed.

Conclusion

Perinatal environmental exposures have distinct effects on maternal-infant outcomes. Neurotoxicant exposure and limited access to restorative environments may negatively impact early neurodevelopment, while noise reduction may support maternal mental health. These findings underscore the importance of environmental factors in shaping early development and highlight the need for further research into underlying biological mechanisms and long-term effects.

极早产儿（VPT）面临较高的神经发育风险。围产期环境暴露的影响，其中复杂因素可能影响产妇心理健康和婴儿结局，仍然知之甚少。本研究探讨了联合环境暴露与产后母亲焦虑和VPT婴儿神经发育的关系。方法：我们纳入了2010-2013年在大伦敦出生的427名VPT婴儿。我们得出了住宅环境暴露：空气污染物、噪音和开放空间。聚类分析确定了暴露概况。在足月等龄（38-44周），婴儿接受t2加权MRI检查脑容量和皮质特征分析。产妇焦虑，足月评估；神经发育，18-24个月时评估；在调整社会经济地位（SES）后，比较不同暴露组之间的大脑发育情况。我们进一步探讨了SES在环境暴露中的作用。结果：出现了三种暴露谱。与第1组（参考文献；n = 358）相比，第2组（n = 42）的特点是空气质量差，开放空间有限，认知延迟的风险更高，社会经济劣势更大。相反，第3组（n = 27；低噪音暴露）表现出降低的母亲焦虑。环境因素对认知延迟的影响占20.91%。在脑容量或皮质特征上没有观察到显著差异。结论：围产期环境暴露对母婴结局有明显影响。接触神经毒物和接触恢复性环境的机会有限可能对早期神经发育产生负面影响，而减少噪音可能有助于产妇的心理健康。这些发现强调了环境因素在塑造早期发育中的重要性，并强调了进一步研究潜在生物学机制和长期影响的必要性。

{"title":"Perinatal environmental exposures, maternal mental health and cognitive outcomes in very preterm infants born in urban London","authors":"Zeyuan Sun , Kaili Liang , Andrew Lawrence , Marguerite Leoni , Serena J. Counsell , Paola Dazzan , A David Edwards , Chiara Nosarti","doi":"10.1016/j.ijheh.2025.114740","DOIUrl":"10.1016/j.ijheh.2025.114740","url":null,"abstract":"<div><h3>Introduction</h3><div>Very preterm (VPT) infants face elevated neurodevelopmental risks. The impact of perinatal environmental exposures, where complex factors may affect maternal mental health and infant outcomes, remains poorly understood. This study examines how joint environmental exposures relate to postnatal maternal anxiety and neurodevelopment in VPT infants.</div></div><div><h3>Methods</h3><div>We included 427 VPT infants born in Greater London (2010–2013). We derived residential environmental exposures: air pollutants, noise, and open space. Clustering analysis identified exposure profiles. At term-equivalent age (38–44 weeks), infants underwent T2-weighted MRI for brain volume and cortical feature analysis. Maternal anxiety, assessed at term; neurodevelopment, evaluated at 18–24 months; and brain development were compared between exposure clusters, adjusting for socioeconomic status (SES). We further explored the role of SES in environmental exposure.</div></div><div><h3>Results</h3><div>Three exposure profiles emerged. Compared to Group 1 (reference; n = 358), Group 2 (n = 42), characterised by poor air quality and limited open space, had a higher risk of cognitive delay and greater socioeconomic disadvantage. Conversely, Group 3 (n = 27; low noise exposure) exhibited reduced maternal anxiety. SES contributed 20.91 % of the environmental effect on cognitive delay. No significant differences in brain volumes or cortical features were observed.</div></div><div><h3>Conclusion</h3><div>Perinatal environmental exposures have distinct effects on maternal-infant outcomes. Neurotoxicant exposure and limited access to restorative environments may negatively impact early neurodevelopment, while noise reduction may support maternal mental health. These findings underscore the importance of environmental factors in shaping early development and highlight the need for further research into underlying biological mechanisms and long-term effects.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"272 ","pages":"Article 114740"},"PeriodicalIF":4.4,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145852072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In utero and early childhood exposure to per- and polyfluoroalkyl substances and use of antibiotics in children from the Odense Child Cohort: A Danish cohort study 来自欧登塞儿童队列的儿童在子宫和幼儿期接触全氟烷基和多氟烷基物质以及抗生素的使用：一项丹麦队列研究。

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-24 DOI: 10.1016/j.ijheh.2025.114734

Nete Lundager Klokker Rausgaard , Lise Gehrt , Martin Thomsen Ernst , Iben Have Beck , Flemming Nielsen , Helene Kildegaard , Anton Pottegård , Tina Kold Jensen , Lars Christian Lund

Background

Per- and polyfluoroalkyl substances (PFAS) have been associated with an increased risk of infectious diseases. We aimed to investigate if in utero and early childhood exposure to PFAS was associated with the number of antibiotic prescriptions up to eight years of age.

Methods

Among 2448 singleton mother-child pairs from the Odense Child Cohort, 1425 had sufficient information on key variables and were included in the primary analysis. Information on redeemed antibiotic prescriptions from birth to eight years of age was obtained from the Danish National Prescription Registry. Longitudinal discrete-time Poisson models were used to quantify the relationship between PFAS and the number of antibiotic prescriptions redeemed. Analyses were carried out separately for PFAS measured in the mother during pregnancy and in the child at 18 months of age. Missing information was imputed using Multiple Imputation by Chained Equations.

Results

We observed no differences in the number of antibiotic prescriptions in the first eight years of life when comparing median and high PFAS concentrations measured in both pregnancy and at 18 months of age (rate ratio PFOA 1.01, 95 % confidence interval 0.94–1.08; PFOS 1.08, 0.98–1.19; PFNA 1.00, 0.94–1.07; PFDA 0.99, 0.94–1.04; PFHxS 1.02, 0.98–1.07).

Conclusion

We found no association between in utero or early childhood PFAS concentrations and number of antibiotic prescriptions up to eight years of age. Antibiotic prescriptions may be an unspecific marker of childhood infections, hampering the possibility to observe an association with PFAS exposure.

Trial registration

Real World Evidence Registry: https://osf.io/dyqxm, registered March 8, 2023.

背景：全氟和多氟烷基物质（PFAS）与传染病风险增加有关。我们的目的是调查在子宫和儿童早期暴露于PFAS是否与8岁前抗生素处方的数量有关。方法：在欧登塞儿童队列的2448对独生子女中，1425对关键变量信息充分，纳入初步分析。从出生到8岁的抗生素处方的信息是从丹麦国家处方登记处获得的。使用纵向离散泊松模型来量化PFAS与抗生素处方赎回数量之间的关系。分别对母亲怀孕期间和孩子18个月时的PFAS进行分析。缺失信息的输入采用链式方程的多重输入。结果：比较妊娠期和18月龄时PFAS中位浓度和高浓度时，我们观察到前8年抗生素处方数量无差异（比率比PFOA 1.01, 95%可信区间0.94-1.08;PFOS 1.08, 0.98-1.19; PFNA 1.00, 0.94-1.07; PFDA 0.99, 0.94-1.04; PFHxS 1.02, 0.98-1.07）。结论：我们没有发现子宫内或儿童早期PFAS浓度与8岁前抗生素处方数量之间的关联。抗生素处方可能是儿童感染的非特异性标记，阻碍了观察与PFAS暴露相关的可能性。试验注册：Real World Evidence Registry: https://osf.io/dyqxm， 2023年3月8日注册。

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引用次数: 0

Association between residential proximity to crop areas and childhood acute leukemia risk in mainland France – GEOCAP case-control study 在法国大陆，居住地靠近种植区与儿童急性白血病风险的关系——GEOCAP病例对照研究

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-23 DOI: 10.1016/j.ijheh.2025.114737

Matthieu Mancini , Laure Faure , Claire Poulalhon , Aurélie Danjou , Stéphanie Goujon

Background

Pesticide exposures are suspected to be a risk factor for several childhood cancers, particularly acute leukemia (AL) and the most common type, acute lymphoblastic leukemia (ALL). The role of environmental exposures due to agricultural uses of pesticides remains debated.

Objective

The study aimed to investigate whether residential proximity to different crops, used as a proxy for pesticide exposures, is associated with an increased risk of AL in France.

Methods

We included 2731 AL cases diagnosed in 2008–2013 and 28,303 controls representative of the contemporary French pediatric population (1–14 years old), drawn from the national registry-based GEOCAP study. National annual maps of agricultural land use were developed to assess proximity to 13 crop types. Multivariate logistic regression models adjusted for age were used to evaluate the association with the densities of crops within 1000 m of children's addresses. A hierarchical classification was also used to categorize children according to their agricultural neighborhood profiles.

Results

The majority of children (69 %) lived less than 1000 m from crops at time of diagnosis/inclusion. Barley and viticulture densities were positively associated with ALL: Odds ratio (OR) = 1.05 (1.00–1.10) and 1.06 (0.99–1.13) for a density increase of 3 % and 10 %, respectively. Two agricultural neighborhood profiles were also associated with an increased risk of ALL: ‘Vines (large areas)’, OR = 1.35 (1.03–1.78) and ‘Wheat with diverse crops’, OR = 1.28 (1.10–1.49). The results remained stable across sensitivity analyses.

Conclusion

Our results support the hypothesis of a role of agricultural pesticide exposures in childhood ALL risk. Future research should focus on the chemical substances applied to crops.

背景：农药暴露被怀疑是几种儿童癌症的危险因素，特别是急性白血病（AL）和最常见的急性淋巴细胞白血病（ALL）。由于农业使用农药而造成的环境暴露的作用仍然存在争议。目的：该研究旨在调查法国不同作物的住宅邻近程度（作为农药暴露的代表）是否与AL风险增加有关。方法：我们纳入了2008-2013年诊断的2731例AL病例和28,303例对照，这些病例代表了当代法国儿科人群（1-14岁），来自全国基于登记的GEOCAP研究。制定了全国农业土地利用年度地图，以评估与13种作物类型的接近程度。使用调整年龄的多变量logistic回归模型来评估与儿童地址1000米内作物密度的关系。分层分类也被用于根据他们的农业社区概况对儿童进行分类。结果：大多数儿童（69%）在诊断/纳入时生活在距离作物不到1000米的地方。大麦和葡萄密度与ALL呈显著正相关：当密度增加3%和10%时，优势比分别为1.05（1.00-1.10）和1.06（0.99-1.13）。两种农业社区情况也与ALL风险增加有关：“葡萄（大面积）”，OR = 1.35（1.03-1.78）和“小麦与多种作物”，OR = 1.28（1.10-1.49）。结果在敏感性分析中保持稳定。结论：我们的研究结果支持农药暴露与儿童ALL风险有关的假设。今后的研究应集中在应用于作物的化学物质上。

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引用次数: 0

Paternal preconception urinary concentrations of bisphenol A and F in relation to in vitro fertilization outcomes: A prospective cohort study 父亲孕前尿双酚A和F浓度与体外受精结果的关系：一项前瞻性队列研究。

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-20 DOI: 10.1016/j.ijheh.2025.114739

Ningxin Zhang , Yue Zhao , Lingling Zhai , Yannan Zhao , Kuai Yu , Lihong Jia

Bisphenol F (BPF), a substitute for the widely recognized environmental endocrine-disrupting chemical bisphenol A (BPA), is increasingly utilized in consumer products. Despite the well-established association of BPA with adverse reproductive outcomes, the association with BPF exposure on in vitro fertilization (IVF) outcomes remains largely unknown, particularly regarding paternal exposure, given that male factors already account for approximately 40 % of global infertility. We aimed to evaluate the associations between exposure to BPA and BPF and IVF outcomes among men undergoing assisted reproductive technology (ART) treatment. The study enrolled 128 men undergoing ART treatment from a prospective cohort study in Shenyang, China, between September 2020 and February 2021. Urinary levels of bisphenols using mass spectrometry. Compared to the lowest quartile, men with urinary BPA concentrations in the highest quartile had 0.10 lower adjusted fertilization rate (95 % CI: 0.18, −0.02). Men with urinary BPA concentrations in the highest quartile had a lower probability of live birth compared to those with concentrations in the lowest quartile (adjusted RR = 0.27, 95 % CI: 0.09, −0.86). The quantile g-computation (QGC) model revealed that per quantile increase in the bisphenol mixture was inversely associated with fertilization rate (adjusted β = −0.04, 95 % CI: 0.07, −0.01) and probability of live birth (adjusted RR = 0.54, 95 % CI: 0.34, 0.85). Male co-exposure to BPA and BPF was inversely associated with IVF outcomes, including reduced fertilization rate and the probability of a live birth. Public health initiatives should prioritize reducing bisphenol exposure in men to mitigate infertility risks, not merely focusing on women.

双酚F （BPF）是公认的环境内分泌干扰化学物质双酚a （BPA）的替代品，在消费品中的应用越来越广泛。尽管双酚a与不良生殖结果的关系已得到证实，但BPA暴露与体外受精（IVF）结果的关系在很大程度上仍然未知，特别是关于父亲暴露，因为男性因素已经占全球不孕症的40%左右。我们的目的是评估在接受辅助生殖技术（ART）治疗的男性中BPA和BPF暴露与IVF结果之间的关系。该研究从2020年9月至2021年2月在中国沈阳进行的一项前瞻性队列研究中招募了128名接受ART治疗的男性。用质谱法测定尿液中双酚类物质的含量。与最低的四分位数相比，尿液中BPA浓度最高的四分位数的男性调整受精率降低了0.10 （95% CI: 0.18, -0.02）。尿中BPA浓度最高的男性与浓度最低的男性相比，活产的可能性更低（调整后RR = 0.27, 95% CI: 0.09, -0.86）。分位数g计算（QGC）模型显示，双酚混合物每增加分位数与受精率（调整后的β = -0.04, 95% CI: 0.07, -0.01）和活产概率（调整后的RR = 0.54, 95% CI: 0.34, 0.85）呈负相关。男性同时暴露于BPA和BPF与体外受精结果呈负相关，包括受精率降低和活产的可能性。公共卫生倡议应优先减少男性双酚暴露，以减轻不育风险，而不仅仅是关注女性。

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引用次数: 0

Psychosocial distress among individuals residing in a rural PFAS-contaminated community 居住在农村pfas污染社区的个体的社会心理困扰

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-19 DOI: 10.1016/j.ijheh.2025.114736

Elizabeth Scharnetzki , Lisa B. Rokoff , Katherine Senechal , Michelle Bosquet Enlow , Abby F. Fleisch , Rachel Criswell

Few studies have evaluated how awareness of PFAS contamination impacts psychosocial distress. We sought to quantify psychosocial distress associated with awareness of drinking water PFAS contamination in the Maine Biosolids Study (n=146), a rural cohort affected by agricultural biosolids spreading. Participants had residential well water PFAS concentrations measured by the Department of Environmental Protection and were notified about concentrations above or below the Maine Interim Drinking Water Standard [∑6 PFAS (PFOA, PFOS, PFNA, PFHxS, PFHpA, PFDA) ≥20 ng/L]. We utilized negative binomial mixed effects regression to study associations of awareness of water PFAS above the Standard with PFAS-related psychosocial outcomes and state-dependent anxiety. We explored effect modification by pre-existing mental health diagnoses and resilience coping style. Fifty-eight percent of participants had drinking water PFAS above the Standard, and 35% had pre-existing mental health diagnoses. Affected participants with drinking water PFAS above the Standard had greater PFAS-related anxiety, worry and fears about health risk, and perceived stigma [for example, IRR_perceived _stigma (95% CI): 1.69 (1.32, 2.15)]. Knowledge of elevated water PFAS was associated with greater state-dependent anxiety, although confidence intervals included the null [IRR (95% CI): 1.21 (0.90, 1.61)]. Associations of awareness of water PFAS with worry about PFAS health risk and state-dependent anxiety were stronger among individuals without a prior mental health diagnosis [e.g., IRR_worry (95% CI): 2.30 (1.49, 3.57) versus 1.27 (0.80, 2.02)]. We found no effect modification by resilience coping style. Individuals with knowledge of elevated drinking water PFAS had greater PFAS-related psychosocial distress. Mental health support and community education are public health needs in PFAS-affected communities.

很少有研究评估PFAS污染的意识如何影响社会心理困扰。在缅因州生物固体研究（n=146）中，我们试图量化与饮用水PFAS污染意识相关的社会心理困扰，这是一个受农业生物固体传播影响的农村队列。参与者饮用了由环境保护部测量的住宅井水PFAS浓度，并被告知浓度高于或低于缅因州临时饮用水标准[∑6 PFAS (PFOA， PFOS， PFNA, PFHxS, PFHpA， PFDA)≥20 ng/L]。我们使用负二项混合效应回归来研究水PFAS高于标准的意识与PFAS相关的社会心理结果和状态依赖性焦虑的关系。本研究探讨了既存心理健康诊断和弹性应对方式对效果的影响。58%的参与者的饮用水PFAS高于标准，35%的参与者有先前存在的精神健康诊断。饮用水PFAS高于标准的受影响参与者有更大的PFAS相关焦虑、对健康风险的担忧和恐惧，以及感知到的耻辱感[例如，未感知到的耻辱感（95% CI）： 1.69(1.32, 2.15)]。尽管置信区间包括空值[IRR (95% CI): 1.21(0.90, 1.61)]，但对水中PFAS升高的了解与更大的状态依赖性焦虑相关。在没有先前心理健康诊断的个体中，对水PFAS的认识与对PFAS健康风险的担忧和状态依赖性焦虑的关联更强[例如，IRRworry (95% CI): 2.30（1.49, 3.57）对1.27(0.80,2.02)]。结果表明，弹性应对方式对效果没有影响。知道饮用水PFAS升高的个体有更大的PFAS相关的社会心理困扰。心理健康支持和社区教育是受pfa影响社区的公共卫生需求。

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引用次数: 0

Per- and polyfluoroalkyl substances serum concentrations during pregnancy and gestational weight gain in the Healthy Start Study 妊娠期全氟和多氟烷基物质血清浓度与妊娠期体重增加的关系

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-19 DOI: 10.1016/j.ijheh.2025.114735

Julia R. Kaplan , Dana Dabelea , Antonia M. Calafat , John L. Adgate , Anne P. Starling

Background

Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent contaminants detected in most humans. PFAS exposure has been linked to adverse health conditions, including excessive gestational weight gain (GWG), though results have been inconsistent.

Methods

Participants (n = 539) were enrolled in the Healthy Start Study, a Colorado-based cohort (2009–2014). Eleven PFAS were measured in serum collected during pregnancy (median 27 weeks of gestation). GWG was quantified in four ways: absolute change in weight during pregnancy; GWG adjusted for the duration of pregnancy (z-score); 3rd trimester rate of weight gain; and categories of recommended GWG according to Institute of Medicine (IOM) guidelines. PFAS detectable in >60 % of samples (perfluorohexane sulfonate [PFHxS], perfluorooctane sulfonate [PFOS], perfluorooctanoate [PFOA], perfluorononanoate [PFNA], and perfluorodecanoate [PFDA]) were analyzed. We fit covariate-adjusted general linear models for continuous outcomes and multinomial logistic regression models for the categorical outcome. We evaluated effect modification by pre-pregnancy body mass index (BMI) categories.

Results

Serum concentrations of PFHxS and PFOS were positively associated with GWG, GWG z-score and greater odds of excessive weight gain. In stratified models, positive associations with GWG were stronger among women with pre-pregnancy BMI classified as overweight compared to those with BMI in the obesity or normal/underweight categories. Mixture analyses suggested that positive associations were largely due to PFOS.

Discussion

In a diverse population of pregnant women with PFAS serum concentrations typical of the U.S. general population, PFOS and PFHxS concentrations were associated with greater GWG. The influence of PFAS may differ by women's BMI status entering pregnancy.

全氟和多氟烷基物质（PFAS）是大多数人体内普遍存在的持久性污染物。PFAS暴露与不良健康状况有关，包括妊娠期体重过度增加（GWG），尽管结果不一致。方法参与者（n = 539）被纳入健康开始研究，这是一个基于科罗拉多州的队列（2009-2014）。在妊娠期间（中位妊娠27周）收集的血清中测量11个PFAS。GWG以四种方式量化：孕期体重绝对变化；经妊娠期调整的GWG (z-score)；妊娠晚期体重增加率；以及根据医学研究所（IOM）指南推荐的GWG类别。对60%的样品（全氟己烷磺酸盐[PFHxS]、全氟辛烷磺酸盐[PFOS]、全氟辛酸盐[PFOA]、全氟壬酸盐[PFNA]和全氟癸酸盐[PFDA]）中可检测到的PFAS进行了分析。我们对连续结果拟合协变量调整的一般线性模型，对分类结果拟合多项逻辑回归模型。我们通过孕前体重指数（BMI）分类来评估效果的改变。结果血清PFHxS和PFOS浓度与GWG、GWG z-score及体重过度增加的几率呈正相关。在分层模型中，与体重指数为肥胖或正常/体重不足类别的女性相比，孕前体重指数为超重的女性与GWG的正相关更强。混合分析表明，正相关主要是由于全氟辛烷磺酸。在一个不同的孕妇人群中，PFOS和PFHxS的浓度与更高的GWG有关，这是典型的美国普通人群的PFAS血清浓度。PFAS的影响可能因孕妇的BMI状况而异。

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引用次数: 0

Integrating PBPK modeling and tobacco biomarkers to interpret N-(2-hydroxyethyl)valine (HEV) hemoglobin adducts in the U.S. population 整合PBPK模型和烟草生物标志物来解释美国人群中的N-（2-羟乙基）缬氨酸（HEV）血红蛋白加合物。

IF 4.4 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health

Pub Date : 2025-12-17 DOI: 10.1016/j.ijheh.2025.114721

Yu-Sheng Lin , Viktor Morozov , Kuen-Yuh Wu

Background

Ethylene oxide (EtO) is a human carcinogen, and cigarette smoke is the leading source of exposure in the general population. In blood, EtO alkylates the N-terminal valine of hemoglobin to form N-(2-hydroxyethyl)valine (HEV), a stable biomarker. Yet HEV levels vary widely, even among smokers. This variability reflects differences in nicotine intake, smoking behavior, endogenous ethylene oxidation, and demographic factors.

Objective

We estimated the contribution of cigarette smoking to HEV levels and evaluated whether combining HEV with nicotine-derived and other tobacco biomarkers improves exposure assessment.

Methods

We analyzed adults from the National Health and Nutrition Examination Survey (NHANES) 2013–2014, the only cycle with both HEV and supplemental smoking biomarkers. Cigarette consumption was estimated from serum cotinine and entered into a physiologically based pharmacokinetic (PBPK) model to predict HEV formation from cigarette-derived EtO. Predicted values were compared with measured HEV levels. Survey-weighted regression examined how demographic factors and other biomarkers contributed to variability.

Results

HEV and other biomarkers were highest in active smokers, followed by passive smokers, and lowest in non-smokers. Predicted HEV matched observed patterns but was consistently 20–30 pmol/g globin lower than measured values. Body weight was a major source of variability, while age and others contributed less. Serum cotinine showed the strongest link with HEV. 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and 2-hydroxyethyl mercapturic acid (2-HEMA) added complementary information across different exposure windows.

Conclusions

Cigarette smoking is the primary source of HEV in the U.S. Using PBPK modeling alongside tobacco biomarkers helps explain variability and supports exposure assessment.

背景：环氧乙烷（EtO）是一种人类致癌物，而香烟烟雾是普通人群暴露的主要来源。在血液中，EtO将血红蛋白的N端缬氨酸烷基化，形成N-（2-羟乙基）缬氨酸（HEV），这是一种稳定的生物标志物。然而，即使在吸烟者中，HEV水平也存在很大差异。这种可变性反映了尼古丁摄入量、吸烟行为、内源性乙烯氧化和人口统计学因素的差异。目的：我们估计吸烟对HEV水平的贡献，并评估将HEV与尼古丁衍生和其他烟草生物标志物结合是否可以改善暴露评估。方法：我们分析了2013-2014年国家健康与营养调查（NHANES）的成年人，这是唯一一个同时使用HEV和补充吸烟生物标志物的周期。根据血清可替宁估计卷烟消费量，并进入基于生理的药代动力学（PBPK）模型，以预测卷烟衍生的EtO形成HEV。预测值与测量的HEV水平进行比较。调查加权回归检验了人口因素和其他生物标记物对变异性的影响。结果：HEV和其他生物标志物在主动吸烟者中最高，其次是被动吸烟者，在非吸烟者中最低。预测的HEV符合观察到的模式，但始终低于20-30 pmol/g球蛋白值。体重是变异的主要来源，而年龄和其他因素的影响较小。血清可替宁与HEV的相关性最强。4-（甲基亚硝胺）-1-（3-吡啶基）-1-丁醇（NNAL）和2-羟乙基巯基酸（2-HEMA）在不同的暴露窗口增加了互补信息。结论：吸烟是美国HEV的主要来源。使用PBPK模型和烟草生物标志物有助于解释变异性并支持暴露评估。

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引用次数: 0