Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114677
Anders Bekkelund, Petter Langlete, Carl Fredrik Nordheim, Tora Alexandra Ziesler, Elisabeth Henie Madslien, Susanne Hyllestad
Climate change is expected to increase the frequency of extreme weather events, challenging the provision of safe drinking water. In August 2023, the extreme flood event Hans severely affected infrastructure in south-eastern Norway. We assessed the impact on drinking water quality in 63 municipalities receiving red flood warnings, covering 138 water supply systems serving ∼845,000 people. Data on E. coli, Clostridium perfringens and intestinal enterococci were retrieved from 93 utilities that reported results before, during, and after the flood. In total, >7000 water samples were analysed. Positive samples were more frequent in raw water (14.6 % E. coli, 32.2 % Clostridiumperfringens, 9.6 % enterococci) than in treated water (≤1.2 %). Significant correlations were observed between river flow and faecal indicator exceedances in both raw and treated water, particularly in the Drammen river basin. These findings indicate increased public health risk during extreme flooding and underscore the vulnerability of drinking water systems to climate-sensitive hazards. The results provide baseline data directly relevant for hazard identification and risk assessment in climate-resilient water safety planning and for implementing the European Drinking Water Directive (EU, 2020/2184).
{"title":"Extreme weather and drinking water safety: impacts of the 2023 flood Hans in Norway","authors":"Anders Bekkelund, Petter Langlete, Carl Fredrik Nordheim, Tora Alexandra Ziesler, Elisabeth Henie Madslien, Susanne Hyllestad","doi":"10.1016/j.ijheh.2025.114677","DOIUrl":"10.1016/j.ijheh.2025.114677","url":null,"abstract":"<div><div>Climate change is expected to increase the frequency of extreme weather events, challenging the provision of safe drinking water. In August 2023, the extreme flood event <em>Hans</em> severely affected infrastructure in south-eastern Norway. We assessed the impact on drinking water quality in 63 municipalities receiving red flood warnings, covering 138 water supply systems serving ∼845,000 people. Data on <em>E. coli</em>, <em>Clostridium perfringens</em> and intestinal enterococci were retrieved from 93 utilities that reported results before, during, and after the flood. In total, >7000 water samples were analysed. Positive samples were more frequent in raw water (14.6 % <em>E. coli</em>, 32.2 % <em>C</em><em>lostridium</em> <em>perfringens</em>, 9.6 % enterococci) than in treated water (≤1.2 %). Significant correlations were observed between river flow and faecal indicator exceedances in both raw and treated water, particularly in the Drammen river basin. These findings indicate increased public health risk during extreme flooding and underscore the vulnerability of drinking water systems to climate-sensitive hazards. The results provide baseline data directly relevant for hazard identification and risk assessment in climate-resilient water safety planning and for implementing the European Drinking Water Directive (EU, 2020/2184).</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114677"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114649
Lindsay J. Underhill , Lisa de las Fuentes , Laura Nicolaou , Shakir Hossen , Anaite Diaz-Artiga , Ajay Pillarisetti , Aris T. Papageorghiou , Florien Ndagijimana , Ghislaine Rosa , Gurusamy Thangavel , John P. McCracken , Kalpana Balakrishnan , Krishnendu Mukhopadhyay , Kyle Steenland , Lisa M. Thompson , Lance A. Waller , Maggie L. Clark , Michael A. Johnson , Sarada Garg , Sankar Sambandam , Victor G. Davila-Roman
Background
Cardiovascular disease is the leading cause of global morbidity and mortality, disproportionately affecting people in low- and middle-income countries (LMICs). Biomass fuels used for cooking in LMICs contribute significantly to household air pollution (HAP), which has been associated with inflammation, oxidative stress, and other pathways linked to atherosclerosis. We evaluate the association between HAP exposure and atherosclerosis by use of carotid artery ultrasound.
Methods
An exposure-response analysis was conducted using cross-sectional baseline data from 397 women aged 40–79 years from the Household Air Pollution Intervention Network (HAPIN) trial in Guatemala, India, Peru, and Rwanda. Participants underwent ultrasound evaluation of their carotid arteries to measure intima-media thickness (CIMT) and atherosclerotic plaques. Additionally, 24-h personal exposures to particulate matter (PM2.5), carbon monoxide (CO), and black carbon (BC) were assessed.
Findings
Mean 24-h PM2.5 exposure was 119 μg/m3 (range 10–803), BC was 13 μg/m3 (range 1.1–72), and CO was 2.3 ppm (range 0–39). Mean and maximal unadjusted CIMT measurements were 0.64 ± 0.13 mm and 0.75 ± 0.14 mm, respectively. Prevalence of atherosclerotic plaques was 7.1 % (range: 0.8 %–11.6 % by country). In adjusted linear models, each 10 μg/m3 increase in PM2.5 was associated with a 0.001 mm increase in mean CIMT (95 % CI: 0 to 0.002) and a 0.002 mm increase in maximal CIMT (95 % CI: 0 to 0.003). For CO, each 10 ppm increase was associated with a 0.04 mm increase in maximal CIMT (95 % CI: 0 to 0.08), with the highest quartile of CO exposure having 0.036 mm and 0.05 mm greater mean and maximal CIMT (95 % CI: 0.002 to 0.07; 0.01, 0.09), respectively, than the lowest quartile. No significant associations were found between BC and CIMT or between any exposures and carotid atherosclerotic plaque.
Interpretation
In this cross-sectional study, higher personal exposures to PM2.5 and CO were associated with greater mean and maximal CIMT, a well-established biomarker of atherosclerosis, further supporting the association between HAP and cardiovascular disease.
背景：心血管疾病是全球发病率和死亡率的主要原因，对低收入和中等收入国家（LMICs）人群的影响尤为严重。在中低收入国家，用于烹饪的生物质燃料对家庭空气污染（HAP）有重大影响，而家庭空气污染与炎症、氧化应激和其他与动脉粥样硬化相关的途径有关。我们通过颈动脉超声评估HAP暴露与动脉粥样硬化之间的关系。方法使用来自危地马拉、印度、秘鲁和卢旺达家庭空气污染干预网络（HAPIN）试验的397名40-79岁妇女的横断面基线数据进行暴露反应分析。参与者接受了颈动脉超声评估，以测量内膜-中膜厚度（CIMT）和动脉粥样硬化斑块。此外，还评估了24小时个人暴露于颗粒物（PM2.5）、一氧化碳（CO）和黑碳（BC）的情况。平均24小时PM2.5暴露量为119 μg/m3（范围10-803），BC为13 μg/m3（范围1.1-72），CO为2.3 ppm（范围0-39）。未调整的平均和最大CIMT测量值分别为0.64±0.13 mm和0.75±0.14 mm。动脉粥样硬化斑块患病率为7.1%（各国范围：0.8% - 11.6%）。在调整后的线性模型中，PM2.5每增加10 μg/m3，平均CIMT增加0.001 mm (95% CI: 0 ~ 0.002)，最大CIMT增加0.002 mm （95% CI: 0 ~ 0.003）。对于CO，每增加10 ppm，最大CIMT增加0.04 mm (95% CI: 0至0.08)，CO暴露的最高四分位数的平均CIMT和最大CIMT分别比最低四分位数高0.036 mm和0.05 mm （95% CI: 0.002至0.07;0.01,0.09）。没有发现BC和CIMT之间或任何暴露与颈动脉粥样硬化斑块之间的显著关联。在这项横断面研究中，PM2.5和CO的个人暴露水平越高，平均和最大的CIMT（动脉粥样硬化的一个公认的生物标志物）越高，进一步支持HAP与心血管疾病之间的关联。
{"title":"Household air pollution exposure in adult women is associated with increased carotid intima-media thickness: A cross-sectional study of the Household Air Pollution Intervention Network trial.","authors":"Lindsay J. Underhill , Lisa de las Fuentes , Laura Nicolaou , Shakir Hossen , Anaite Diaz-Artiga , Ajay Pillarisetti , Aris T. Papageorghiou , Florien Ndagijimana , Ghislaine Rosa , Gurusamy Thangavel , John P. McCracken , Kalpana Balakrishnan , Krishnendu Mukhopadhyay , Kyle Steenland , Lisa M. Thompson , Lance A. Waller , Maggie L. Clark , Michael A. Johnson , Sarada Garg , Sankar Sambandam , Victor G. Davila-Roman","doi":"10.1016/j.ijheh.2025.114649","DOIUrl":"10.1016/j.ijheh.2025.114649","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease is the leading cause of global morbidity and mortality, disproportionately affecting people in low- and middle-income countries (LMICs). Biomass fuels used for cooking in LMICs contribute significantly to household air pollution (HAP), which has been associated with inflammation, oxidative stress, and other pathways linked to atherosclerosis. We evaluate the association between HAP exposure and atherosclerosis by use of carotid artery ultrasound.</div></div><div><h3>Methods</h3><div>An exposure-response analysis was conducted using cross-sectional baseline data from 397 women aged 40–79 years from the Household Air Pollution Intervention Network (HAPIN) trial in Guatemala, India, Peru, and Rwanda. Participants underwent ultrasound evaluation of their carotid arteries to measure intima-media thickness (CIMT) and atherosclerotic plaques. Additionally, 24-h personal exposures to particulate matter (PM<sub>2.5</sub>), carbon monoxide (CO), and black carbon (BC) were assessed.</div></div><div><h3>Findings</h3><div>Mean 24-h PM<sub>2.5</sub> exposure was 119 μg/m<sup>3</sup> (range 10–803), BC was 13 μg/m<sup>3</sup> (range 1.1–72), and CO was 2.3 ppm (range 0–39). Mean and maximal unadjusted CIMT measurements were 0.64 ± 0.13 mm and 0.75 ± 0.14 mm, respectively. Prevalence of atherosclerotic plaques was 7.1 % (range: 0.8 %–11.6 % by country). In adjusted linear models, each 10 μg/m<sup>3</sup> increase in PM<sub>2.5</sub> was associated with a 0.001 mm increase in mean CIMT (95 % CI: 0 to 0.002) and a 0.002 mm increase in maximal CIMT (95 % CI: 0 to 0.003). For CO, each 10 ppm increase was associated with a 0.04 mm increase in maximal CIMT (95 % CI: 0 to 0.08), with the highest quartile of CO exposure having 0.036 mm and 0.05 mm greater mean and maximal CIMT (95 % CI: 0.002 to 0.07; 0.01, 0.09), respectively, than the lowest quartile. No significant associations were found between BC and CIMT or between any exposures and carotid atherosclerotic plaque.</div></div><div><h3>Interpretation</h3><div>In this cross-sectional study, higher personal exposures to PM<sub>2.5</sub> and CO were associated with greater mean and maximal CIMT, a well-established biomarker of atherosclerosis, further supporting the association between HAP and cardiovascular disease.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114649"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bloodstream infections (BSIs) are a major cause of neonatal morbidity and mortality in low-resource settings, yet most are preventable. However, few studies evaluated the effectiveness of multimodal interventions in preventing healthcare-associated BSIs (HA-BSIs) in neonatal intensive care units (NICUs) in low- and middle-income countries (LMICs).
Methods
We conducted an implementation study in a NICU in Northern Ethiopia from January to June 2024, using a pre-and post-intervention design. Multimodal prevention strategies consisted of infection prevention and control (IPC) training, the appointment of an IPC expert, in-house production of alcohol-based hand rub (ABHR), HA-BSI surveillance, and online IPC meetings. Follow-up interventions were implemented based on feedback from these meetings. Logistic regression analysis was used to assess the associations between variables.
Results
Among 151 clinically suspected HA-BSI episodes, 58.3 % were culture-positive. The baseline rate of HA-BSI was 333 episodes per 1000 hospital admissions. This rate significantly declined to 74 within two months (p < 0.0001) and 96 episodes per 1000 by the end of the study (p < 0.0001). HA-BSI-associated mortality decreased by 80 % (p < 0.0001). Each additional hospital day increased HA-BSI risk by 10.5 % (odds ratio [OR]: 1.105, 95 % confidence interval [CI]: 1.018–1.200; p < 0.05), while a 100-g increase in birth weight improved the odds of successful antibiotic treatment by 15.2 % (OR: 1.152, 95 % CI: 1.055–1.257; p < 0.01).
Conclusion
Cost-effective, multimodal IPC interventions can significantly reduce HA-BSIs and associated mortality in NICUs in low-resource settings. Further research is needed to evaluate the long-term sustainability of these measures in LMICs.
血液感染（bsi）是低资源环境中新生儿发病和死亡的主要原因，但大多数是可以预防的。然而，很少有研究评估多模式干预措施在中低收入国家新生儿重症监护病房（nicu）预防医疗保健相关脑梗死（ha - bsi）的有效性。方法采用干预前和干预后设计，于2024年1月至6月在埃塞俄比亚北部的一所新生儿重症监护室进行实施研究。多模式预防战略包括感染预防和控制（IPC）培训、任命一名IPC专家、室内生产含酒精的洗手液（ABHR）、HA-BSI监测以及在线IPC会议。根据这些会议的反馈意见实施了后续干预措施。采用Logistic回归分析评估变量之间的相关性。结果151例临床怀疑HA-BSI发作中，58.3%为培养阳性。HA-BSI的基线发生率为每1000例住院患者333例。这一比率在两个月内显著下降到74例（p < 0.0001），在研究结束时每1000人发作96例（p < 0.0001）。ha - bsi相关死亡率降低了80% （p < 0.0001）。每增加一个住院日，HA-BSI风险增加10.5%（优势比[OR]: 1.105, 95%可信区间[CI]: 1.018-1.200; p < 0.05），而出生体重每增加100克，抗生素治疗成功的几率提高15.2% （OR: 1.152, 95% CI: 1.055-1.257; p < 0.01）。结论低成本、多模式IPC干预可显著降低低资源环境下nicu ha - bsi和相关死亡率。需要进一步研究来评估这些措施在中低收入国家的长期可持续性。
{"title":"Impact of infection prevention interventions on neonatal bloodstream infections and mortality in Ethiopia","authors":"Friederike Lemm , Hailemariam Gebrearegay Haileeyesus , Kiros Weldegerima Gezahegn , Simret Niguse Weldebirhan , Shishay Abay Nigusse , Amanuel Hadgu Berhe , Niguse Tsegay Gebre , Kibra Hailu Desta , Eden Kassahun Gebreegziabher , Kaleb Birhanu Bugudom , Meskelu Kidu Weldetensae , Mengistu Hagazi Tequare , Kibrom Gebreselassie Desta , Haileslassie Berhe , Hailemichael Embafrash Berhe , Monika Kasper-Sonnenberg , Mulugeta Naizgi Gebremicael","doi":"10.1016/j.ijheh.2025.114676","DOIUrl":"10.1016/j.ijheh.2025.114676","url":null,"abstract":"<div><h3>Introduction</h3><div>Bloodstream infections (BSIs) are a major cause of neonatal morbidity and mortality in low-resource settings, yet most are preventable. However, few studies evaluated the effectiveness of multimodal interventions in preventing healthcare-associated BSIs (HA-BSIs) in neonatal intensive care units (NICUs) in low- and middle-income countries (LMICs).</div></div><div><h3>Methods</h3><div>We conducted an implementation study in a NICU in Northern Ethiopia from January to June 2024, using a pre-and post-intervention design. Multimodal prevention strategies consisted of infection prevention and control (IPC) training, the appointment of an IPC expert, in-house production of alcohol-based hand rub (ABHR), HA-BSI surveillance, and online IPC meetings. Follow-up interventions were implemented based on feedback from these meetings. Logistic regression analysis was used to assess the associations between variables.</div></div><div><h3>Results</h3><div>Among 151 clinically suspected HA-BSI episodes, 58.3 % were culture-positive. The baseline rate of HA-BSI was 333 episodes per 1000 hospital admissions. This rate significantly declined to 74 within two months (p < 0.0001) and 96 episodes per 1000 by the end of the study (p < 0.0001). HA-BSI-associated mortality decreased by 80 % (p < 0.0001). Each additional hospital day increased HA-BSI risk by 10.5 % (odds ratio [OR]: 1.105, 95 % confidence interval [CI]: 1.018–1.200; p < 0.05), while a 100-g increase in birth weight improved the odds of successful antibiotic treatment by 15.2 % (OR: 1.152, 95 % CI: 1.055–1.257; p < 0.01).</div></div><div><h3>Conclusion</h3><div>Cost-effective, multimodal IPC interventions can significantly reduce HA-BSIs and associated mortality in NICUs in low-resource settings. Further research is needed to evaluate the long-term sustainability of these measures in LMICs.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114676"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114590
Jennie Sotelo-Orozco , Antonia M. Calafat , Julianne Cook Botelho , Rebecca J. Schmidt , Irva Hertz-Picciotto , Deborah H. Bennett
{"title":"Corrigendum to “Exposure to endocrine disrupting chemicals including phthalates, phenols, and parabens in infancy: Associations with neurodevelopmental outcomes in the MARBLES study” [IJHEH 261 (2024) 114425]","authors":"Jennie Sotelo-Orozco , Antonia M. Calafat , Julianne Cook Botelho , Rebecca J. Schmidt , Irva Hertz-Picciotto , Deborah H. Bennett","doi":"10.1016/j.ijheh.2025.114590","DOIUrl":"10.1016/j.ijheh.2025.114590","url":null,"abstract":"","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114590"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114666
Marie Tartaglia , Calvin Ge , Anjoeka Pronk , Nathalie Costet , Sabyne Audignon-Durand , Marie-Tülin Houot , Katarina Kjellberg , Maxime Turuban , Nel Roeleveld , Jack Siemiatycki , Camille Carles , Corinne Pilorget , Daniel Falkstedt , Sanni Uuksulainen , Michelle C. Turner , Alexis Descatha , Marie Noëlle Dufourg , Fleur Delva , Ronan Garlantézec
Objective
To use data-driven approaches to investigate maternal multi-occupational exposures during pregnancy and their effects on intrauterine growth.
Methods
Maternal occupational exposure to 47 factors during pregnancy was evaluated with job-exposure matrices in the French ELFE cohort. The outcomes of interest were birthweight (BW), small for gestational age (SGA) and head circumference (HC). Occupational exposures associated with these outcomes were identified by EWAS, LASSO, and random forest. The five exposures with the strongest effects selected with these approaches were included in a final multivariate model with significant interactions.
Results
We included 12,851 women. The most important occupational factors predictive of SGA were endocrine disruptors, high strain, kneeling/squatting, job demands, physical effort. No significant associations were detected when these variables were combined in a final model. For BW, the most important variables were leaning forward/sideways, using a computer screen, ultrafine particles, physical effort, airborne germs, repetitive actions. The use of a computer screen significantly decreased BW and, for women not exposed to airborne germs, leaning forward/sideways significantly increased BW. For HC, repetitive actions, oxygenated solvents, kneeling/squatting, airborne germs, working outdoors were the most important predictive factors. Repetitive actions and working outdoors significantly decreased HC. HC also decreased in women exposed to both airborne germs, and oxygenated solvents. Similar results were found for women who worked during the third trimester.
Conclusion
Our findings highlight potential roles of chemical, biological and postural factors and their interactions in determining intrauterine growth. These results highlight the importance of considering multiple exposures in occupational health studies.
{"title":"Multiple maternal occupational exposures during pregnancy and intrauterine growth: analysis of the French Longitudinal Study of Children - ELFE cohort, using data-driven approaches","authors":"Marie Tartaglia , Calvin Ge , Anjoeka Pronk , Nathalie Costet , Sabyne Audignon-Durand , Marie-Tülin Houot , Katarina Kjellberg , Maxime Turuban , Nel Roeleveld , Jack Siemiatycki , Camille Carles , Corinne Pilorget , Daniel Falkstedt , Sanni Uuksulainen , Michelle C. Turner , Alexis Descatha , Marie Noëlle Dufourg , Fleur Delva , Ronan Garlantézec","doi":"10.1016/j.ijheh.2025.114666","DOIUrl":"10.1016/j.ijheh.2025.114666","url":null,"abstract":"<div><h3>Objective</h3><div>To use data-driven approaches to investigate maternal multi-occupational exposures during pregnancy and their effects on intrauterine growth.</div></div><div><h3>Methods</h3><div>Maternal occupational exposure to 47 factors during pregnancy was evaluated with job-exposure matrices in the French ELFE cohort. The outcomes of interest were birthweight (BW), small for gestational age (SGA) and head circumference (HC). Occupational exposures associated with these outcomes were identified by EWAS, LASSO, and random forest. The five exposures with the strongest effects selected with these approaches were included in a final multivariate model with significant interactions.</div></div><div><h3>Results</h3><div>We included 12,851 women. The most important occupational factors predictive of SGA were endocrine disruptors, high strain, kneeling/squatting, job demands, physical effort. No significant associations were detected when these variables were combined in a final model. For BW, the most important variables were leaning forward/sideways, using a computer screen, ultrafine particles, physical effort, airborne germs, repetitive actions. The use of a computer screen significantly decreased BW and, for women not exposed to airborne germs, leaning forward/sideways significantly increased BW. For HC, repetitive actions, oxygenated solvents, kneeling/squatting, airborne germs, working outdoors were the most important predictive factors. Repetitive actions and working outdoors significantly decreased HC. HC also decreased in women exposed to both airborne germs, and oxygenated solvents. Similar results were found for women who worked during the third trimester.</div></div><div><h3>Conclusion</h3><div>Our findings highlight potential roles of chemical, biological and postural factors and their interactions in determining intrauterine growth. These results highlight the importance of considering multiple exposures in occupational health studies.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114666"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114672
Domenica Hahn , Aline Murawski , Philipp Zimmermann , Maria I.H. Schmied-Tobies , Enrico Rucic , Isabel Rühl , Malgorzata Debiak , Thomas Göen , Moritz Schäfer , Marike Kolossa-Gehring
Antimony (Sb) is widely applied in industrial processes as well as in the manufacturing of consumer goods. The metalloid and many of its inorganic compounds can cause adverse health effects, with Antimony trioxide classified as possibly carcinogenic to humans (IARC group 2 B). In the German Environmental Survey for Children and Adolescents 2014–2017 (GerES V), a population-representative cross-sectional survey which combines questionnaire investigations and comprehensive human biomonitoring, the urine of 2250 children and adolescents aged 3–17 years was analysed for Sb.
Sb was detected in 79 % of the participants, with a geometric mean (GM) of 0.053 μg/L. Factors such as younger age, lower socioeconomic status (SES), number of smokers in the household, higher traffic intensity in the close vicinity of the home were significantly associated (p-value ≤0.05) with increased Sb levels in both bivariate and multivariable analyses. Compared to GerES IV (2003–2006), a decrease in Sb exposure of approximately 50 % was observed. However, assessing the health impact of our findings is challenging, particularly since Sb appears to play a key role in the joint effects of harmful metal mixtures.
{"title":"The metalloid antimony in urine of children and adolescents in Germany – human biomonitoring results of the German Environmental Survey 2014–2017 (GerES V)","authors":"Domenica Hahn , Aline Murawski , Philipp Zimmermann , Maria I.H. Schmied-Tobies , Enrico Rucic , Isabel Rühl , Malgorzata Debiak , Thomas Göen , Moritz Schäfer , Marike Kolossa-Gehring","doi":"10.1016/j.ijheh.2025.114672","DOIUrl":"10.1016/j.ijheh.2025.114672","url":null,"abstract":"<div><div>Antimony (Sb) is widely applied in industrial processes as well as in the manufacturing of consumer goods. The metalloid and many of its inorganic compounds can cause adverse health effects, with Antimony trioxide classified as possibly carcinogenic to humans (IARC group 2 B). In the German Environmental Survey for Children and Adolescents 2014–2017 (GerES V), a population-representative cross-sectional survey which combines questionnaire investigations and comprehensive human biomonitoring, the urine of 2250 children and adolescents aged 3–17 years was analysed for Sb.</div><div>Sb was detected in 79 % of the participants, with a geometric mean (GM) of 0.053 μg/L. Factors such as younger age, lower socioeconomic status (SES), number of smokers in the household, higher traffic intensity in the close vicinity of the home were significantly associated (p-value ≤0.05) with increased Sb levels in both bivariate and multivariable analyses. Compared to GerES IV (2003–2006), a decrease in Sb exposure of approximately 50 % was observed. However, assessing the health impact of our findings is challenging, particularly since Sb appears to play a key role in the joint effects of harmful metal mixtures.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114672"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114673
Nozomi Tatsuta, Miyuki Iwai-Shimada, Tomohiko Isobe, Shoji F. Nakayama, Makiko Sekiyama, Mai Takagi, Yayoi Kobayashi, Yu Taniguchi, Shin Yamazaki, the Japan Environment and Children's Study Group
Objective
Previous studies have suggested that perfluoroalkyl and polyfluoroalkyl substances (PFAS) could be related to the occurrence of miscarriages, but the results are inconclusive. Therefore, this study aimed to assess the effects of PFAS exposure during the first trimester on miscarriages that occurred between 12 and 22 weeks of gestation.
Methods
The participants were mothers and infants that registered for the Japan Environment and Children's Study. Twenty-eight PFAS, including perfluorooctanoic acid, perfluorohexane sulfonate, and perfluorooctane sulfonate, were identified in the plasma collected from pregnant participants. Miscarriage information was transcribed from the medical records. A propensity score was used to select the control group (mothers that gave live births), that matched the miscarriage group. The detection and concentrations of the PFAS in the miscarriage and control groups were compared.
Results
Among 24,412 pairs of maternal PFAS measurements, 66 miscarriages (0.3 %) were documented. No significant differences in the detections or concentrations of PFAS were found between the miscarriage and live birth groups (p > 0.196).
Conclusions
No association between prenatal PFAS exposure and late miscarriage was observed. Further studies are required owing to the small sample size.
{"title":"Association between exposure to perfluoroalkyl compounds during early pregnancy and risk of late miscarriage: The Japan Environment and Children's Study","authors":"Nozomi Tatsuta, Miyuki Iwai-Shimada, Tomohiko Isobe, Shoji F. Nakayama, Makiko Sekiyama, Mai Takagi, Yayoi Kobayashi, Yu Taniguchi, Shin Yamazaki, the Japan Environment and Children's Study Group","doi":"10.1016/j.ijheh.2025.114673","DOIUrl":"10.1016/j.ijheh.2025.114673","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies have suggested that perfluoroalkyl and polyfluoroalkyl substances (PFAS) could be related to the occurrence of miscarriages, but the results are inconclusive. Therefore, this study aimed to assess the effects of PFAS exposure during the first trimester on miscarriages that occurred between 12 and 22 weeks of gestation.</div></div><div><h3>Methods</h3><div>The participants were mothers and infants that registered for the Japan Environment and Children's Study. Twenty-eight PFAS, including perfluorooctanoic acid, perfluorohexane sulfonate, and perfluorooctane sulfonate, were identified in the plasma collected from pregnant participants. Miscarriage information was transcribed from the medical records. A propensity score was used to select the control group (mothers that gave live births), that matched the miscarriage group. The detection and concentrations of the PFAS in the miscarriage and control groups were compared.</div></div><div><h3>Results</h3><div>Among 24,412 pairs of maternal PFAS measurements, 66 miscarriages (0.3 %) were documented. No significant differences in the detections or concentrations of PFAS were found between the miscarriage and live birth groups (p > 0.196).</div></div><div><h3>Conclusions</h3><div>No association between prenatal PFAS exposure and late miscarriage was observed. Further studies are required owing to the small sample size.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114673"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114670
Kenyah Lawler , Alison Behie , Alice Richardson
Natural disasters have generally been associated with an increase in adverse birth outcomes, including preterm birth (PTB) and low birthweight (LBW) – two key markers of infant health that are predictive of infant mortality and life-long medical disabilities. However, there is considerable inconsistency between studies which makes it difficult to inform policy on pregnancy during and after natural disasters. In this study, we identify risk factors for pregnant women by undertaking the first meta-analysis on this topic, synthesising data from 42 studies with over 24 million participants. We also perform sub-group analysis on disaster type, a country's economic development, and trimester of exposure, addressing associations that can often not be examined in single studies. We found natural disasters to be associated with increased odds of both LBW (OR = 1.063) and PTB (OR = 1.075), with the largest effects seen from exposure in low Human Development Index countries (LBW: OR = 1.130; PTB: OR = 1.315), in first trimester (LBW: OR = 1.079; PTB: OR = 1.153), and following earthquake exposure for PTB (OR = 1.154). Our findings highlight the importance of directing disaster recovery efforts towards these vulnerable groups, to minimise the impacts on infant health following natural disasters.
自然灾害通常与不良出生结果的增加有关，包括早产（PTB）和低出生体重（LBW）——婴儿健康的两个关键标志，可预测婴儿死亡率和终身医疗残疾。然而，研究之间存在相当大的不一致性，这使得在自然灾害期间和之后为有关怀孕的政策提供信息变得困难。在这项研究中，我们通过对这一主题进行首次荟萃分析，综合了42项研究的数据，超过2400万参与者，确定了孕妇的危险因素。我们还对灾害类型、一个国家的经济发展和暴露的三个月进行了分组分析，解决了通常无法在单一研究中检查的关联。我们发现自然灾害与LBW （OR = 1.063）和PTB （OR = 1.075）的几率增加有关，在人类发展指数较低的国家（LBW: OR = 1.130; PTB: OR = 1.315）、妊娠早期（LBW: OR = 1.079; PTB: OR = 1.153）和地震后暴露于PTB （OR = 1.154）的影响最大。我们的研究结果强调了将灾难恢复工作导向这些弱势群体的重要性，以尽量减少自然灾害对婴儿健康的影响。
{"title":"A systematic review with meta-analysis on the effects of maternal exposure to natural disasters on human birth outcomes","authors":"Kenyah Lawler , Alison Behie , Alice Richardson","doi":"10.1016/j.ijheh.2025.114670","DOIUrl":"10.1016/j.ijheh.2025.114670","url":null,"abstract":"<div><div>Natural disasters have generally been associated with an increase in adverse birth outcomes, including preterm birth (PTB) and low birthweight (LBW) – two key markers of infant health that are predictive of infant mortality and life-long medical disabilities. However, there is considerable inconsistency between studies which makes it difficult to inform policy on pregnancy during and after natural disasters. In this study, we identify risk factors for pregnant women by undertaking the first meta-analysis on this topic, synthesising data from 42 studies with over 24 million participants. We also perform sub-group analysis on disaster type, a country's economic development, and trimester of exposure, addressing associations that can often not be examined in single studies. We found natural disasters to be associated with increased odds of both LBW (OR = 1.063) and PTB (OR = 1.075), with the largest effects seen from exposure in low Human Development Index countries (LBW: OR = 1.130; PTB: OR = 1.315), in first trimester (LBW: OR = 1.079; PTB: OR = 1.153), and following earthquake exposure for PTB (OR = 1.154). Our findings highlight the importance of directing disaster recovery efforts towards these vulnerable groups, to minimise the impacts on infant health following natural disasters.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114670"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-01DOI: 10.1016/j.ijheh.2025.114654
Alexis M. Temkin , Varun Subramaniam , Alexa Friedman , Elvira Fleury , Dayna de Montagnac , Chris Campbell , David Q. Andrews , Olga V. Naidenko
Pesticide exposure has been linked to chronic health harms, yet the effects of cumulative dietary exposure to pesticide mixtures are poorly understood. A pesticide load index was created to rank produce based on pesticide contamination from national pesticide residue testing data for 44 produce types, primarily collected from 2013 to 2018. Three indices were created utilizing different indicators of pesticide contamination and toxicity. Dietary pesticide exposure scores for 1837 individuals were calculated based on produce consumption from the 2015–2016 National Health and Nutrition Examination Survey (NHANES). Covariate-adjusted weighted linear regressions were used to estimate the change in average pesticide biomarker rank relative to dietary pesticide exposure scores. Pesticide load indices were calculated based on detections of 178 unique parent pesticides, or 42 parent pesticides with matched urinary biomarkers in NHANES. Increasing dietary pesticide exposure scores were not associated with average pesticide biomarker rank (β [95 % CI] = 0.02 [-0.34, 0.38]) and were consistent across scores that utilized the different indices. Matching pesticides in food and urine, results in a slightly stronger association (β [95 % CI] = 0.09 [-0.32, 0.51]). Excluding potatoes resulted in a positive significant association (β [95 % CI] = 0.75 [0.35, 1.14]). When excluding potatoes, consumption of fruits and vegetables weighted by pesticide contamination was associated with higher levels of urinary pesticide biomarkers for organophosphate, pyrethroid, and neonicotinoid insecticides. Future research could use this methodology, with the recommendation to exclude potatoes, to assess the impact of dietary pesticide exposure on health outcomes.
{"title":"A cumulative dietary pesticide exposure score based on produce consumption is associated with urinary pesticide biomarkers in a U.S. biomonitoring cohort","authors":"Alexis M. Temkin , Varun Subramaniam , Alexa Friedman , Elvira Fleury , Dayna de Montagnac , Chris Campbell , David Q. Andrews , Olga V. Naidenko","doi":"10.1016/j.ijheh.2025.114654","DOIUrl":"10.1016/j.ijheh.2025.114654","url":null,"abstract":"<div><div>Pesticide exposure has been linked to chronic health harms, yet the effects of cumulative dietary exposure to pesticide mixtures are poorly understood. A pesticide load index was created to rank produce based on pesticide contamination from national pesticide residue testing data for 44 produce types, primarily collected from 2013 to 2018. Three indices were created utilizing different indicators of pesticide contamination and toxicity. Dietary pesticide exposure scores for 1837 individuals were calculated based on produce consumption from the 2015–2016 National Health and Nutrition Examination Survey (NHANES). Covariate-adjusted weighted linear regressions were used to estimate the change in average pesticide biomarker rank relative to dietary pesticide exposure scores. Pesticide load indices were calculated based on detections of 178 unique parent pesticides, or 42 parent pesticides with matched urinary biomarkers in NHANES. Increasing dietary pesticide exposure scores were not associated with average pesticide biomarker rank (β [95 % CI] = 0.02 [-0.34, 0.38]) and were consistent across scores that utilized the different indices. Matching pesticides in food and urine, results in a slightly stronger association (β [95 % CI] = 0.09 [-0.32, 0.51]). Excluding potatoes resulted in a positive significant association (β [95 % CI] = 0.75 [0.35, 1.14]). When excluding potatoes, consumption of fruits and vegetables weighted by pesticide contamination was associated with higher levels of urinary pesticide biomarkers for organophosphate, pyrethroid, and neonicotinoid insecticides. Future research could use this methodology, with the recommendation to exclude potatoes, to assess the impact of dietary pesticide exposure on health outcomes.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114654"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Due to the adverse health effects reported for several phthalate plasticizers, many phthalates have been increasingly replaced with alternatives in various consumer applications. In this study, we employed urine samples collected from the nationally representative populations of 2010 (n = 785) and 2018 (n = 799) and measured metabolites (n = 37) of major phthalate and non-phthalate plasticizers. Exposure levels of phthalates and non-phthalate plasticizers were compared, and their associated risks were assessed. Over the period, on average, urinary metabolite concentrations of major phthalates like DEHP and DBP decreased by 26 % and 31 %, respectively. In contrast, urinary metabolites of DEHTP and DEHA increased by 2131 % and 33 %, respectively. Metabolite profiles varied by age group, with DEHTP showing the highest levels among infants and children. Urinary metabolite concentrations of conventional phthalates showed the least reduction, and those of non-phthalate plasticizers exhibited the greatest increases during this period. Despite regulatory efforts against the use of several phthalates, the estimated daily intake (EDI) for all plasticizers has doubled among infants and children during this period, with DEHA being identified as a major contributor. Overall risk estimated based on anti-androgenicity decreased between 2010 and 2018, but DEHP and DBP remained significant risk drivers despite regulations during this period. Further research on exposure sources is warranted to inform measures that reduce exposure to plasticizers among the vulnerable populations identified in the present study.
{"title":"Exposure to conventional and non-phthalate plasticizers in representative Korean population between 2010 and 2018: Sex and age-stratified comparisons","authors":"Joeun Jung , Jin-Yeong Heo , Na-Youn Park , Younglim Kho , Kyungho Choi","doi":"10.1016/j.ijheh.2025.114679","DOIUrl":"10.1016/j.ijheh.2025.114679","url":null,"abstract":"<div><div>Due to the adverse health effects reported for several phthalate plasticizers, many phthalates have been increasingly replaced with alternatives in various consumer applications. In this study, we employed urine samples collected from the nationally representative populations of 2010 (n = 785) and 2018 (n = 799) and measured metabolites (n = 37) of major phthalate and non-phthalate plasticizers. Exposure levels of phthalates and non-phthalate plasticizers were compared, and their associated risks were assessed. Over the period, on average, urinary metabolite concentrations of major phthalates like DEHP and DBP decreased by 26 % and 31 %, respectively. In contrast, urinary metabolites of DEHTP and DEHA increased by 2131 % and 33 %, respectively. Metabolite profiles varied by age group, with DEHTP showing the highest levels among infants and children. Urinary metabolite concentrations of conventional phthalates showed the least reduction, and those of non-phthalate plasticizers exhibited the greatest increases during this period. Despite regulatory efforts against the use of several phthalates, the estimated daily intake (EDI) for all plasticizers has doubled among infants and children during this period, with DEHA being identified as a major contributor. Overall risk estimated based on anti-androgenicity decreased between 2010 and 2018, but DEHP and DBP remained significant risk drivers despite regulations during this period. Further research on exposure sources is warranted to inform measures that reduce exposure to plasticizers among the vulnerable populations identified in the present study.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"270 ","pages":"Article 114679"},"PeriodicalIF":4.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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