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Drinking water sources, quality, and associated health outcomes in Appalachian Virginia: A risk characterization study in two counties 阿巴拉契亚弗吉尼亚州的饮用水源、水质和相关健康结果:两个县的风险特征研究。
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-05-20 DOI: 10.1016/j.ijheh.2024.114390
Alasdair Cohen , Md Rasheduzzaman , Bethesda O'Connell , Teresa Brown , Mami Taniuchi , Leigh-Anne Krometis , Alan Hubbard , Phillip Scheuerman , Marc Edwards , Amanda Darling , Blaine Pennala , Sarah Price , Breanna Lytton , Erin Wettstone , Suporn Pholwat , Honorine Ward , Daniel R. Hallinger , Steven O. Simmons , Shannon M. Griffin , Jason Kobylanski , Timothy J. Wade

Objectives

In the US, violations of drinking water regulations are highest in lower-income rural areas overall, and particularly in Central Appalachia. However, data on drinking water use, quality, and associated health outcomes in rural Appalachia are limited. We sought to assess public and private drinking water sources and associated risk factors for waterborne pathogen exposures for individuals living in rural regions of Appalachian Virginia.

Methods

We administered surveys and collected tap water, bottled water, and saliva samples in lower-income households in two adjacent rural counties in southwest Virginia (bordering Kentucky and Tennessee). Water samples were tested for pH, temperature, conductivity, total coliforms, E. coli, free chlorine, nitrate, fluoride, heavy metals, and specific pathogen targets. Saliva samples were analyzed for antibody responses to potentially waterborne infections. We also shared water analysis results with households.

Results

We enrolled 33 households (83 individuals), 82% (n = 27) with utility-supplied water and 18% with private wells (n = 3) or springs (n = 3). 58% (n = 19) reported household incomes of <$20,000/year. Total coliforms were detected in water samples from 33% (n = 11) of homes, E. coli in 12%, all with wells or springs (n = 4), and Aeromonas, Campylobacter, and Enterobacter in 9%, all spring water (n = 3). Diarrhea was reported for 10% of individuals (n = 8), but was not associated with E. coli detection. 34% (n = 15) of saliva samples had detectable antibody responses for Cryptosporidium spp., C. jejuni, and Hepatitis E. After controlling for covariates and clustering, individuals in households with septic systems and straight pipes had significantly higher likelihoods of antibody detection (risk ratios = 3.28, 95%CI = 1.01–10.65).

Conclusions

To our knowledge, this is the first study to collect and analyze drinking water samples, saliva samples, and reported health outcome data from low-income households in Central Appalachia. Our findings indicate that utility-supplied water in this region was generally safe, and individuals in low-income households without utility-supplied water or sewerage have higher exposures to waterborne pathogens.

目标:在美国,收入较低的农村地区,尤其是阿巴拉契亚中部地区,违反饮用水法规的情况最为严重。然而,有关阿巴拉契亚农村地区饮用水的使用、质量和相关健康结果的数据却很有限。我们试图评估生活在弗吉尼亚州阿巴拉契亚农村地区的个人的公共和私人饮用水源以及接触水传播病原体的相关风险因素:我们对弗吉尼亚州西南部(与肯塔基州和田纳西州接壤)两个相邻农村县的低收入家庭进行了调查,并收集了自来水、瓶装水和唾液样本。对水样进行了 pH 值、温度、电导率、总大肠菌群、大肠杆菌、游离氯、硝酸盐、氟化物、重金属和特定病原体目标的检测。对唾液样本进行了分析,以检测其对潜在水传播感染的抗体反应。我们还与住户分享了水分析结果:我们登记了 33 个家庭(83 人),其中 82% 的家庭(n = 27)使用公用事业供水,18% 的家庭使用私人水井(n = 3)或泉水(n = 3)。58%(n = 19)的家庭收入为结论收入:据我们所知,这是第一项收集和分析阿巴拉契亚中部低收入家庭的饮用水样本、唾液样本和报告的健康结果数据的研究。我们的研究结果表明,该地区的自来水总体上是安全的,而没有自来水或下水道的低收入家庭中的个人接触水传播病原体的几率更高。
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引用次数: 0
Systematic evidence mapping of potential correlates of exposure for per- and poly-fluoroalkyl substances (PFAS) based on measured occurrence in biomatrices and surveys of dietary consumption and product use 根据生物矩阵中测得的全氟烷基和多氟烷基物质(PFAS)发生率以及膳食消费和产品使用调查,对接触该物质的潜在相关因素进行系统证据分析
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-05-11 DOI: 10.1016/j.ijheh.2024.114384
Chris Holder , Elaine A. Cohen Hubal , Jeanne Luh , Madison G. Lee , Lisa Jo Melnyk , Kent Thomas

Per- and poly-fluoroalkyl substances (PFAS) are widely observed in environmental media and often are found in indoor environments as well as personal-care and consumer products. Humans may be exposed through water, food, indoor dust, air, and the use of PFAS-containing products. Information about relationships between PFAS exposure sources and pathways and the amounts found in human biomatrices can inform source-contribution assessments and provide targets for exposure reduction. This work collected and collated evidence for correlates of PFAS human exposure as measured through sampling of biomatrices and surveys of dietary consumption and use of consumer products and articles. A systematic evidence mapping approach was applied to perform a literature search, conduct title-abstract and full-text screening, and to extract primary data into a comprehensive database for 16 PFAS. Parameters of interest included: sampling dates and locations, cohort descriptors, PFAS measured in a human biomatrix, information about food consumption in 11 categories, use of products/articles in 11 categories, and reported correlation values (and their statistical strength). The literature search and screening process yielded 103 studies with information for correlates of PFAS exposures. Detailed data were extracted and compiled on measures of PFAS correlations between biomatrix concentrations and dietary consumption and other product/article use. A majority of studies (61/103; 59%) were published after 2015 with few (8/103; 8%) prior to 2010. Studies were most abundant for dietary correlates (n = 94) with fewer publications reporting correlate assessments for product use (n = 56), while some examined both. PFOA and PFOS were assessed in almost all studies, followed by PFHxS, PFNA, and PFDA which were included in >50% of the studies. No relevant studies included PFNS or PFPeS. Among the 94 studies of dietary correlates, significant correlations were reported in 83% of the studies for one or more PFAS. The significant dietary correlations most commonly were for seafood, meats/eggs, and cereals/grains/pulses. Among the 56 studies of product/article correlates, significant correlations were reported in 70% of the studies. The significant product/article correlations most commonly were for smoking/tobacco, cosmetics/toiletries, non-stick cookware, and carpet/flooring/furniture and housing. Six of 11 product/article categories included five or fewer studies, including food containers and stain- and water-resistant products. Significant dietary and product/article correlations most commonly were positive. Some studies found a mix of positive and negative correlations depending on the PFAS, specific correlate, and specific response level, particularly for fats/oils, dairy consumption, food containers, and cosmetics/toiletries. Most of the significant findings for cereals/grains/pulses were negative correlations. Substantial evidence was found for correlations betwee

全氟烷基和多氟烷基物质(PFAS)广泛存在于环境介质中,通常在室内环境以及个人护理和消费品中发现。人类可能通过水、食物、室内灰尘、空气以及使用含 PFAS 的产品接触到这些物质。有关全氟辛烷磺酸暴露来源和途径与人体生物体内含量之间关系的信息可以为来源贡献评估提供依据,并为减少暴露提供目标。这项工作收集并整理了通过生物矩阵采样、膳食消费调查以及消费品和物品的使用情况来测量的人类接触 PFAS 的相关证据。采用系统证据图谱法进行文献检索、标题-摘要和全文筛选,并将 16 种全氟辛烷磺酸的原始数据提取到综合数据库中。相关参数包括:采样日期和地点、队列描述符、在人体生物矩阵中测量到的 PFAS、11 个类别的食品消费信息、11 个类别的产品/文章使用情况以及报告的相关值(及其统计强度)。通过文献检索和筛选过程,获得了 103 项研究的相关信息,这些信息涉及 PFAS 暴露的相关因素。我们提取并汇编了生物矩阵浓度与膳食消费和其他产品/微粒使用之间的 PFAS 相关性测量的详细数据。大多数研究(61/103;59%)发表于 2015 年之后,只有少数研究(8/103;8%)发表于 2010 年之前。关于膳食相关性的研究最多(n = 94),而报告产品使用相关性评估的出版物较少(n = 56),但有些研究对两者都进行了研究。几乎所有研究都对全氟辛烷磺酸和全氟辛烷磺酸进行了评估,其次是全氟己烷磺酸、全氟萘磺酸和全氟辛烷磺酸,50%的研究纳入了这些物质。没有相关研究包括 PFNS 或 PFPeS。在 94 项膳食相关性研究中,83% 的研究报告了一种或多种 PFAS 的显著相关性。膳食相关性最常见的是海产品、肉类/蛋类和谷物/谷物/豆类。在 56 项关于产品/物品相关性的研究中,70% 的研究报告了显著的相关性。最常见的具有重大相关性的产品/物品是烟草、化妆品/厕所、不粘锅以及地毯/地板/家具和住房。在 11 个产品/物品类别中,有 6 个类别包含 5 项或更少的研究,包括食品容器和防污防水产品。显著的膳食和产品/物品相关性多为正相关。一些研究发现,根据全氟辛烷磺酸、特定相关物质和特定反应水平的不同,正相关和负相关并存,尤其是脂肪/油、乳制品消费、食品容器和化妆品/盥洗用品。谷物/谷物/豆类的大部分重要发现都是负相关。有大量证据表明,在多个食品类别中,膳食摄入量与几种全氟辛烷磺酸的生物矩阵水平之间存在相关性。除吸烟/烟草外,对产品/物品使用关系的研究相对较少,因此需要开展更多的研究。由此产生的数据库可为进一步评估膳食和产品使用的暴露关系提供信息,并可为更好地了解 PFAS 来源与暴露关系的新研究提供信息。应扩展并实施该搜索策略,以支持这一快速发展领域的活体证据审查。
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引用次数: 0
Maternal residential exposure to solvents from industrial sources during pregnancy and childhood cancer risk in California 加利福尼亚州孕产妇在怀孕期间接触工业来源溶剂的情况与儿童患癌风险
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-05-04 DOI: 10.1016/j.ijheh.2024.114388
Yixin Chen , Darcy Van Deventer , Roch Nianogo , Marco Vinceti , Wei Kang , Myles Cockburn , Noah Federman , Julia E. Heck

Background

Maternal solvent exposure has been suspected to increase offspring cancer risk. The study aimed to evaluate the associations between maternal residential exposure to solvents from industrial pollution during pregnancy and childhood cancer.

Methods

The present study included 15,744 cancer cases (aged 0–19 years at diagnosis) identified from California Cancer Registry and 283,141 controls randomly selected from California Birth Registry (20:1 frequency-matched by birth year: 1998–2016). We examined industrial releases of tetrachloroethylene and 1,1,1-trichloroethane within 3 km of the birth address, while we used a 5 km buffer for carbon disulfide. We calculated the total exposure from all linked Toxic Release Inventory sites during each index pregnancy and assigned “ever/never” and “high/low exposed/unexposed” exposure, using median values. We performed quadratic decay models to estimate cancer risks associated with maternal solvent exposure in pregnancy.

Results

1,1,1-Trichloroethane was associated with rhabdomyosarcoma (adjusted Odds Ratio (aOR): 1.96; 95% Confidence Interval (CI): 1.16, 3.32) in the “ever exposed” group. Ever exposure to carbon disulfide was associated with increased risks of medulloblastoma (OR = 1.85, 95% CI 1.01, 3.40) and ependymoma (OR = 1.63, 95% CI 0.97, 2.74).

Conclusions

Overall, our findings suggested maternal residential exposure to solvents from industrial sources might be associated with elevated childhood cancer risks.

背景母亲接触溶剂被怀疑会增加后代患癌症的风险。本研究纳入了从加利福尼亚癌症登记处确认的 15,744 例癌症病例(确诊时年龄为 0-19 岁)和从加利福尼亚出生登记处随机选取的 283,141 例对照(按出生年份进行频率匹配,比例为 20:1:1998-2016)。我们检查了出生地址 3 公里范围内的四氯乙烯和 1,1,1- 三氯乙烷工业排放情况,而二硫化碳则使用了 5 公里缓冲区。我们计算了每次指数妊娠期间所有相关有毒物质释放清单站点的总暴露量,并使用中值分配了 "曾经/从未 "和 "高/低暴露/未暴露 "暴露量。结果1,1,1-三氯乙烷与 "曾经接触 "组中的横纹肌肉瘤有关(调整后的比值比 (aOR):1.96;95% 置信区间 (CI):1.16, 3.32)。总之,我们的研究结果表明,母亲在住宅中接触工业来源的溶剂可能与儿童癌症风险升高有关。
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引用次数: 0
Sex and adrenal hormones in association with insecticide biomarkers among adolescents living in ecuadorian agricultural communities 生活在厄瓜多尔农业社区的青少年的性激素和肾上腺激素与杀虫剂生物标志物的关系
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-05-03 DOI: 10.1016/j.ijheh.2024.114386
Briana N.C. Chronister , Denise Justo , Robert Wood , Dolores Lopez-Paredes , Eduardo Gonzalez , Jose Suarez-Torres , Sheila Gahagan , Danilo Martinez , David R. Jacobs (Jr.) , Harvey Checkoway , Marta M. Jankowska , Jose R. Suarez-Lopez

Background

Organophosphate, pyrethroid, and neonicotinoid insecticides have resulted in adrenal and gonadal hormone disruption in animal and in vitro studies; limited epidemiologic evidence exists in humans. We assessed relationships of urinary insecticide metabolite concentrations with adrenal and gonadal hormones in adolescents living in Ecuadorean agricultural communities.

Methods

In 2016, we examined 522 Ecuadorian adolescents (11-17y, 50.7% female, 22% Indigenous; ESPINA study). We measured urinary insecticide metabolites, blood acetylcholinesterase activity (AChE), and salivary testosterone, dehydroepiandrosterone (DHEA), 17β-estradiol, and cortisol. We used general linear models to assess linear (β = % hormone difference per 50% increase of metabolite concentration) and curvilinear relationships (β2 = hormone difference per unit increase in squared ln-metabolite) between ln-metabolite or AChE and ln-hormone concentrations, stratified by sex, adjusting for anthropometric, demographic, and awakening response variables. Bayesian Kernel Machine Regression was used to assess non-linear associations and interactions.

Results

The organophosphate metabolite malathion dicarboxylic acid (MDA) had positive associations with testosterone (βboys = 5.88% [1.21%, 10.78%], βgirls = 4.10% [-0.02%, 8.39%]), and cortisol (βboys = 6.06 [-0.23%, 12.75%]. Para-nitrophenol (organophosphate) had negatively-trending curvilinear associations, with testosterone (β2boys = −0.17 (−0.33, −0.003), p = 0.04) and DHEA (β2boys = −0.49 (−0.80, −0.19), p = 0.001) in boys. The neonicotinoid summary score (βboys = 5.60% [0.14%, 11.36%]) and the neonicotinoid acetamiprid-N-desmethyl (βboys = 3.90% [1.28%, 6.58%]) were positively associated with 17β-estradiol, measured in boys only. No associations between the pyrethroid 3-phenoxybenzoic acid and hormones were observed. In girls, bivariate response associations identified interactions of MDA, Para-nitrophenol, and 3,5,6-trichloro-2-pyridinol (organophosphates) with testosterone and DHEA concentrations. In boys, we observed an interaction of MDA and Para-nitrophenol with DHEA. No associations were identified for AChE.

Conclusions

We observed evidence of endocrine disruption for specific organophosphate and neonicotinoid metabolite exposures in adolescents. Urinary organophosphate metabolites were associated with testosterone and DHEA concentrations, with stronger associations in boys than girls. Urinary neonicotinoids were positively associated with 17β-estradiol. Longitudinal repeat-measures analyses would be beneficial for causal inference.

背景在动物和体外研究中,有机磷、拟除虫菊酯和新烟碱类杀虫剂会导致肾上腺和性腺激素紊乱;在人类中,流行病学证据有限。我们评估了生活在厄瓜多尔农业社区的青少年尿液中杀虫剂代谢物浓度与肾上腺和性腺激素的关系。方法2016年,我们对522名厄瓜多尔青少年(11-17岁,50.7%为女性,22%为土著人;ESPINA研究)进行了调查。我们测量了尿液中的杀虫剂代谢物、血液中乙酰胆碱酯酶活性(AChE)以及唾液中的睾酮、脱氢表雄酮(DHEA)、17β-雌二醇和皮质醇。我们使用一般线性模型评估了ln-代谢物或AChE与ln-激素浓度之间的线性关系(β=代谢物浓度每增加50%激素差异的百分比)和曲线关系(β2=ln-代谢物平方每增加一个单位激素差异),并按性别进行了分层,同时对人体测量、人口统计学和觉醒反应变量进行了调整。结果有机磷代谢物马拉硫磷二羧酸(MDA)与睾酮(β男孩=5.88% [1.21%,10.78%],β女孩=4.10% [-0.02%,8.39%])和皮质醇(β男孩=6.06 [-0.23%,12.75%])呈正相关。对硝基苯酚(有机磷)与男孩的睾酮(β2 boys = -0.17 (-0.33, -0.003),p = 0.04)和 DHEA(β2 boys = -0.49 (-0.80, -0.19),p = 0.001)呈负曲线关系。新烟碱总分(βboys = 5.60% [0.14%, 11.36%])和新烟碱啶虫脒-N-去甲基(βboys = 3.90% [1.28%, 6.58%])与 17β-estradiol 呈正相关(仅在男孩中测量)。没有观察到拟除虫菊酯 3-苯氧基苯甲酸与激素之间的关联。在女孩中,二元反应关联确定了 MDA、对硝基苯酚和 3,5,6-三氯-2-吡啶醇(有机磷)与睾酮和 DHEA 浓度之间的相互作用。在男孩中,我们观察到 MDA 和对硝基苯酚与 DHEA 之间存在相互作用。结论我们观察到有证据表明,青少年接触特定有机磷和新烟碱类代谢物会干扰内分泌。尿液中的有机磷代谢物与睾酮和 DHEA 浓度有关,男孩的相关性强于女孩。尿液中的新烟碱与 17β-estradiol 呈正相关。纵向重复测量分析有利于推断因果关系。
{"title":"Sex and adrenal hormones in association with insecticide biomarkers among adolescents living in ecuadorian agricultural communities","authors":"Briana N.C. Chronister ,&nbsp;Denise Justo ,&nbsp;Robert Wood ,&nbsp;Dolores Lopez-Paredes ,&nbsp;Eduardo Gonzalez ,&nbsp;Jose Suarez-Torres ,&nbsp;Sheila Gahagan ,&nbsp;Danilo Martinez ,&nbsp;David R. Jacobs (Jr.) ,&nbsp;Harvey Checkoway ,&nbsp;Marta M. Jankowska ,&nbsp;Jose R. Suarez-Lopez","doi":"10.1016/j.ijheh.2024.114386","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114386","url":null,"abstract":"<div><h3>Background</h3><p>Organophosphate, pyrethroid, and neonicotinoid insecticides have resulted in adrenal and gonadal hormone disruption in animal and <em>in vitro</em> studies; limited epidemiologic evidence exists in humans. We assessed relationships of urinary insecticide metabolite concentrations with adrenal and gonadal hormones in adolescents living in Ecuadorean agricultural communities.</p></div><div><h3>Methods</h3><p>In 2016, we examined 522 Ecuadorian adolescents (11-17y, 50.7% female, 22% Indigenous; ESPINA study). We measured urinary insecticide metabolites, blood acetylcholinesterase activity (AChE), and salivary testosterone, dehydroepiandrosterone (DHEA), 17β-estradiol, and cortisol. We used general linear models to assess linear (β = % hormone difference per 50% increase of metabolite concentration) and curvilinear relationships (β<sup>2</sup> = hormone difference per unit increase in squared ln-metabolite) between ln-metabolite or AChE and ln-hormone concentrations, stratified by sex, adjusting for anthropometric, demographic, and awakening response variables. Bayesian Kernel Machine Regression was used to assess non-linear associations and interactions.</p></div><div><h3>Results</h3><p>The organophosphate metabolite malathion dicarboxylic acid (MDA) had positive associations with testosterone (β<sub>boys</sub> = 5.88% [1.21%, 10.78%], β<sub>girls</sub> = 4.10% [-0.02%, 8.39%]), and cortisol (β<sub>boys</sub> = 6.06 [-0.23%, 12.75%]. <em>Para-</em>nitrophenol (organophosphate) had negatively-trending curvilinear associations, with testosterone (β<sup>2</sup><sub>boys</sub> = −0.17 (−0.33, −0.003), p = 0.04) and DHEA (β<sup>2</sup><sub>boys</sub> = −0.49 (−0.80, −0.19), p = 0.001) in boys. The neonicotinoid summary score (β<sub>boys</sub> = 5.60% [0.14%, 11.36%]) and the neonicotinoid acetamiprid-N-desmethyl (β<sub>boys</sub> = 3.90% [1.28%, 6.58%]) were positively associated with 17β-estradiol, measured in boys only. No associations between the pyrethroid 3-phenoxybenzoic acid and hormones were observed. In girls, bivariate response associations identified interactions of MDA, <em>Para-</em>nitrophenol, and 3,5,6-trichloro-2-pyridinol (organophosphates) with testosterone and DHEA concentrations. In boys, we observed an interaction of MDA and <em>Para-</em>nitrophenol with DHEA. No associations were identified for AChE.</p></div><div><h3>Conclusions</h3><p>We observed evidence of endocrine disruption for specific organophosphate and neonicotinoid metabolite exposures in adolescents. Urinary organophosphate metabolites were associated with testosterone and DHEA concentrations, with stronger associations in boys than girls. Urinary neonicotinoids were positively associated with 17β-estradiol. Longitudinal repeat-measures analyses would be beneficial for causal inference.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140825145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing a multimodal intervention using local resources to improve hand hygiene compliance in a comprehensive specialized hospital in Mekelle, Northern Ethiopia 利用当地资源实施多模式干预,改善埃塞俄比亚北部默克莱一家综合专科医院的手部卫生依从性
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-05-03 DOI: 10.1016/j.ijheh.2024.114389
Mulugeta Naizgi Gebremicael , Adriane Skaletz-Rorowski , Anja Potthoff , Joshua Lemm , Monika Kasper-Sonnenberg , Zekarias Gessesse Arefaine , Selin Temizel , Friederike Lemm

Background

Hand hygiene (HH) is known to be the most effective practice to reduce Healthcare-associated infections (HAIs). The main barriers to HH practices among healthcare workers (HCWs) in Sub-Saharan Africa are heavy workload, infrastructural deficits, and poorly positioned facilities. There is limited data on HH compliance and particularly on the impact of the World Health Organization's (WHO) multimodal HH strategy in low- and middle-income countries. This study aimed to provide insights into a strategy to implement the WHO concept adapted to local conditions and obstacles encountered at a tertiary university hospital in Mekelle, Tigray, Ethiopia.

Methods

We conducted a study aiming at increasing the quality of the HH practice of HCWs using the WHO HH improvement strategy. The study adopted a pre-and post-interventional design from April 2018 to May 2019. In the pre-intervention phase, a baseline infrastructural survey was made. The intervention consisted of in-house production of hand sanitizer and dispensers for every patient bed, staff education and motivation, and implementation of a multidisciplinary infection prevention committee. The intervention was followed by two one-week compliance observations of HH practice among HCWs within the six months post-intervention period and microbiological sample collection from HCWs' hands to assess the quality of HH.

Results

We observed 269 (baseline), 737 (first follow-up) and 574 (second follow-up) indications for HH among HCWs. The overall baseline hand rub compliance was 4.8%, which significantly increased to 37.3% (first follow-up) and 56.1% (second follow-up) (p < 0.0001). Consistent and significant increases in hand rub compliance during the entire follow-up period were observed before touching a patient, after touching a patient, and after touching the patient's surroundings (all p < 0.01). Nurses and medical interns achieved consistent and significant increases in hand rub compliance during the entire follow-up period (all p < 0.01).

Conclusion

Implementing the WHO HH improvement strategy significantly increased HH compliance despite a shortage of water and other resources. Hand rub was accepted as the main HH method in the hospital. HH campaigns in developing settings profit from multimodal strategies, knowledge exchange and utilization of local resources.

背景众所周知,手卫生(HH)是减少医疗保健相关感染(HAI)最有效的方法。在撒哈拉以南非洲地区,医护人员(HCWs)实施手卫生的主要障碍是繁重的工作量、基础设施不足以及设施位置不佳。有关保健卫生合规性,特别是世界卫生组织(WHO)的多模式保健卫生战略对中低收入国家的影响的数据十分有限。本研究旨在深入探讨埃塞俄比亚提格雷省梅凯莱市一所三级大学医院根据当地条件和遇到的障碍实施世卫组织理念的策略。方法我们开展了一项研究,旨在利用世卫组织保健改善策略提高医护人员的保健实践质量。研究采用了干预前和干预后设计,时间为 2018 年 4 月至 2019 年 5 月。在干预前阶段,进行了基线基础设施调查。干预措施包括内部生产洗手液并为每张病床配备分配器、员工教育和激励以及实施多学科感染预防委员会。干预结束后的六个月内,我们对医护人员的洗手操作进行了两次为期一周的观察,并从医护人员的手部采集微生物样本,以评估洗手的质量。擦手依从性的总体基线值为 4.8%,在第一次随访和第二次随访中分别显著上升至 37.3%和 56.1%(p < 0.0001)。在整个随访期间,接触病人前、接触病人后和接触病人周围环境后的擦手依从性均有持续、显著的提高(所有 p < 0.01)。在整个随访期间,护士和实习医生的擦手依从性持续显著提高(均为 p < 0.01)。医院将擦手作为主要的保健方法。在发展中环境中开展的净手运动可从多模式策略、知识交流和利用当地资源中获益。
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引用次数: 0
Human biomonitoring follow-up study on PFOA contamination and investigation of possible influencing factors on PFOA exposure in a German population originally exposed to emissions from a fluoropolymer production plant 关于全氟辛烷磺酸污染的人体生物监测跟踪研究,以及对最初接触含氟聚合物生产厂排放物的德国人群接触全氟辛烷磺酸的可能影响因素的调查
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-05-03 DOI: 10.1016/j.ijheh.2024.114387
Heidi Lahne , Doris Gerstner , Wolfgang Völkel , Wolfgang Schober , Bettina Aschenbrenner , Caroline Herr , Stefanie Heinze , Caroline Quartucci

Background

In the past, perfluorooctanoic acid (PFOA) was produced and applied as an emulsifier in a fluoropolymer production plant in the Altötting district, southern Bavaria (Germany). This chemical was released directly into the environment, resulting in the contamination of the local drinking water. During a human biomonitoring (HBM) survey in 2018, increased median PFOA blood serum levels, compared to a normally exposed control group with no known source of PFOA exposure from Munich, Germany, were detected in the resident population (23.18 μg/l in the general population, 20.71 μg/l in the children's group). The follow-up study aimed to investigate whether purification of the drinking water as the main PFOA exposure source has been successful in reducing internal PFOA exposure and to estimate the association of internal PFOA exposure with possible influencing factors.

Methods

Only individuals who had already participated in the HBM study in 2018 were included. For the determination of the PFOA serum concentration, 5 ml of blood was drawn from each participating person. Blood samples were collected in the period from June to August 2022. Furthermore, information on sociodemographic characteristics, health status, dietary behaviour and other lifestyle factors were collected by means of a self-administered questionnaire. To examine the association of PFOA blood serum levels with possible influencing factors, such as age, gender and consumption of fish and game meat, a logistic regression model with a PFOA value > 10 μg/l as outcome was used.

Results

A total of 764 individuals participated in the follow-up study in 2022. Analyses were performed separately for the general population (n = 559), women of reproductive age (15–49 years old) (n = 120), and children under 12 years old (n = 30). Median PFOA blood levels have decreased by 56.9% in the general population, by 59.8% in the group of women of reproductive age and by 73.4% in the group of children under 12 years old. In the general population, a higher probability of a PFOA value > 10 μg/l was found for those aged 40–59 years (Odds ratio (OR) = 2.33 (95%CI: 1.23 to 4.43, p = 0.01) and those aged 60 years and older (OR = 5.32, 95%CI: 2.78 to 10.19, p < 0.001).

Conclusions

In all study groups, the median PFOA serum levels decreased as expected after a half-life of four years, which confirms that contamination via drinking water has ceased. Furthermore, our study identified age as a significant predictor of internal PFOA exposure, while no influence was found for the consumption of fish and game meat. Further investigations are needed to quantify in a more detailed way the influence of dietary habits on PFOA exposure.

背景过去,德国巴伐利亚州南部 Altötting 地区的一家含氟聚合物生产厂生产并使用全氟辛酸(PFOA)作为乳化剂。这种化学物质被直接排放到环境中,导致当地饮用水受到污染。在 2018 年的一项人体生物监测(HBM)调查中,与德国慕尼黑的一个没有已知 PFOA 暴露源的正常暴露对照组相比,在常住人口中检测到 PFOA 血液血清中值水平升高(普通人群为 23.18 μg/l,儿童组为 20.71 μg/l)。后续研究旨在调查作为主要 PFOA 暴露源的饮用水净化是否成功地减少了体内 PFOA 暴露,并估计体内 PFOA 暴露与可能的影响因素之间的关联。方法仅纳入 2018 年已参与 HBM 研究的个人。为测定PFOA血清浓度,每位参与者抽取了5毫升血液。血样采集时间为 2022 年 6 月至 8 月。此外,还通过自填式问卷收集了有关社会人口特征、健康状况、饮食行为和其他生活方式因素的信息。为了研究血清中 PFOA 含量与可能的影响因素(如年龄、性别、鱼类和野味的食用量)之间的关系,我们使用了一个以 PFOA 值 > 10 μg/l 为结果的逻辑回归模型。分别对普通人群(559 人)、育龄妇女(15-49 岁)(120 人)和 12 岁以下儿童(30 人)进行了分析。普通人群的全氟辛烷磺酸血药浓度中值下降了 56.9%,育龄妇女下降了 59.8%,12 岁以下儿童下降了 73.4%。在普通人群中,40-59 岁人群中 PFOA 值为 10 μg/l 的概率较高(OR = 2.33(95%CI:1.23-4.43,p = 0.01)),60 岁及以上人群中 PFOA 值为 10 μg/l 的概率较高(OR = 5.结论在所有研究组中,中位 PFOA 血清水平在 4 年的半衰期后如预期般下降,这证实通过饮用水造成的污染已经停止。此外,我们的研究还发现,年龄是预测体内 PFOA 暴露的一个重要因素,而食用鱼类和野味没有影响。要更详细地量化饮食习惯对暴露于全氟辛烷磺酸的影响,还需要进一步的调查。
{"title":"Human biomonitoring follow-up study on PFOA contamination and investigation of possible influencing factors on PFOA exposure in a German population originally exposed to emissions from a fluoropolymer production plant","authors":"Heidi Lahne ,&nbsp;Doris Gerstner ,&nbsp;Wolfgang Völkel ,&nbsp;Wolfgang Schober ,&nbsp;Bettina Aschenbrenner ,&nbsp;Caroline Herr ,&nbsp;Stefanie Heinze ,&nbsp;Caroline Quartucci","doi":"10.1016/j.ijheh.2024.114387","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114387","url":null,"abstract":"<div><h3>Background</h3><p>In the past, perfluorooctanoic acid (PFOA) was produced and applied as an emulsifier in a fluoropolymer production plant in the Altötting district, southern Bavaria (Germany). This chemical was released directly into the environment, resulting in the contamination of the local drinking water. During a human biomonitoring (HBM) survey in 2018, increased median PFOA blood serum levels, compared to a normally exposed control group with no known source of PFOA exposure from Munich, Germany, were detected in the resident population (23.18 μg/l in the general population, 20.71 μg/l in the children's group). The follow-up study aimed to investigate whether purification of the drinking water as the main PFOA exposure source has been successful in reducing internal PFOA exposure and to estimate the association of internal PFOA exposure with possible influencing factors.</p></div><div><h3>Methods</h3><p>Only individuals who had already participated in the HBM study in 2018 were included. For the determination of the PFOA serum concentration, 5 ml of blood was drawn from each participating person. Blood samples were collected in the period from June to August 2022. Furthermore, information on sociodemographic characteristics, health status, dietary behaviour and other lifestyle factors were collected by means of a self-administered questionnaire. To examine the association of PFOA blood serum levels with possible influencing factors, such as age, gender and consumption of fish and game meat, a logistic regression model with a PFOA value &gt; 10 μg/l as outcome was used.</p></div><div><h3>Results</h3><p>A total of 764 individuals participated in the follow-up study in 2022. Analyses were performed separately for the general population (n = 559), women of reproductive age (15–49 years old) (n = 120), and children under 12 years old (n = 30). Median PFOA blood levels have decreased by 56.9% in the general population, by 59.8% in the group of women of reproductive age and by 73.4% in the group of children under 12 years old. In the general population, a higher probability of a PFOA value &gt; 10 μg/l was found for those aged 40–59 years (Odds ratio (OR) = 2.33 (95%CI: 1.23 to 4.43, p = 0.01) and those aged 60 years and older (OR = 5.32, 95%CI: 2.78 to 10.19, p &lt; 0.001).</p></div><div><h3>Conclusions</h3><p>In all study groups, the median PFOA serum levels decreased as expected after a half-life of four years, which confirms that contamination via drinking water has ceased. Furthermore, our study identified age as a significant predictor of internal PFOA exposure, while no influence was found for the consumption of fish and game meat. Further investigations are needed to quantify in a more detailed way the influence of dietary habits on PFOA exposure.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140825146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early childhood exposures to phthalates in association with attention-deficit/hyperactivity disorder behaviors in middle childhood and adolescence in the ReCHARGE study ReCHARGE 研究中儿童早期接触邻苯二甲酸盐与儿童中期和青少年期注意力缺陷/多动症行为的关系
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-04-30 DOI: 10.1016/j.ijheh.2024.114377
Jiwon Oh , Julie B. Schweitzer , Jessie P. Buckley , Sudhi Upadhyaya , Kurunthachalam Kannan , Julie B. Herbstman , Akhgar Ghassabian , Rebecca J. Schmidt , Irva Hertz-Picciotto , Deborah H. Bennett , Environmental influences on Child Health Outcomes

Background

Early-life exposure to phthalates alters behaviors in animals. However, epidemiological evidence on childhood phthalate exposure and attention-deficit/hyperactivity disorder (ADHD) behaviors is limited.

Methods

This study included 243 children from the ReCHARGE (Revisiting Childhood Autism Risks from Genetics and Environment) study, who were previously classified as having autism spectrum disorder (ASD), developmental delay, other early concerns, and typical development in the CHARGE case-control study. Twenty phthalate metabolites were measured in spot urine samples collected from children aged 2–5 years. Parents reported on children's ADHD symptoms at ages 8–18 years using Conners-3 Parent Rating Scale. Covariate-adjusted negative binomial generalized linear models were used to investigate associations between individual phthalate metabolite concentrations and raw scores. Weighted quantile sum (WQS) regression with repeated holdout validation was used to examine mixture effects of phthalate metabolites on behavioral scores. Effect modification by child sex was evaluated.

Results

Among 12 phthalate metabolites detected in >75% of the samples, higher mono-2-heptyl phthalate (MHPP) was associated with higher scores on Inattentive (β per doubling = 0.05, 95% confidence interval [CI]: 0.02, 0.08) and Hyperactive/Impulsive scales (β = 0.04, 95% CI: 0.00, 0.07), especially among children with ASD. Higher mono-carboxy isooctyl phthalate (MCiOP) was associated with higher Hyperactivity/Impulsivity scores (β = 0.07, 95% CI: −0.01, 0.15), especially among typically developing children. The associations of the molar sum of high molecular weight (HMW) phthalate metabolites and a phthalate metabolite mixture with Hyperactivity/Impulsivity scores were modified by sex, showing more pronounced adverse associations among females.

Conclusion

Exposure to phthalates during early childhood may impact ADHD behaviors in middle childhood and adolescence, particularly among females. Although our findings may not be broadly generalizable due to the diverse diagnostic profiles within our study population, our robust findings on sex-specific associations warrant further investigations.

背景早年接触邻苯二甲酸盐会改变动物的行为。本研究纳入了 ReCHARGE(重访遗传与环境导致的儿童自闭症风险)研究中的 243 名儿童,这些儿童之前在 CHARGE 病例对照研究中被归类为患有自闭症谱系障碍 (ASD)、发育迟缓、其他早期问题和典型发育。研究人员从 2-5 岁儿童的尿液样本中检测了 20 种邻苯二甲酸酯代谢物。家长使用康纳斯-3家长评分量表(Conners-3 Parent Rating Scale)报告了儿童在8-18岁时的多动症状。采用协变量调整的负二项广义线性模型来研究单个邻苯二甲酸酯代谢物浓度与原始分数之间的关系。使用加权量子和(WQS)回归和重复保持验证来研究邻苯二甲酸酯代谢物对行为评分的混合效应。结果在75%的样本中检测到的12种邻苯二甲酸酯代谢物中,邻苯二甲酸单-2-庚酯(MHPP)越高,注意力不集中(β每加倍=0.05,95%置信区间[CI]:0.02,0.08)和多动/冲动量表(β=0.04,95%置信区间:0.00,0.07)的得分越高,尤其是在患有自闭症的儿童中。邻苯二甲酸单羧基异辛酯(MCiOP)越高,多动/易冲动得分越高(β = 0.07,95% CI:-0.01,0.15),尤其是在发育典型的儿童中。高分子量(HMW)邻苯二甲酸酯代谢物和邻苯二甲酸酯代谢物混合物的摩尔总和与多动/易冲动得分的关系因性别而异,在女性中显示出更明显的不利关系。尽管由于研究对象的诊断特征各不相同,我们的研究结果可能不具有广泛的普遍性,但我们在性别特异性关联方面的有力发现值得进一步研究。
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引用次数: 0
Associations between serum perfluoroalkyl and polyfluoroalkyl concentrations and diabetes mellitus in the Korean general population: Insights from the Korean National Environmental Health Survey 2018–2020 韩国普通人群血清中全氟烷基和多氟烷基浓度与糖尿病之间的关系:来自 2018-2020 年韩国全国环境健康调查的启示
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-04-26 DOI: 10.1016/j.ijheh.2024.114385
Habyeong Kang , Shin-Hye Kim

Aims

Recent epidemiologic research has examined the relationship between perfluoroalkyl and polyfluoroalkyl substances (PFAS) and diabetes mellitus with inconclusive findings. In this cross-sectional study, we aimed to explore the association between serum PFAS concentrations and the prevalence of prediabetes and pre-diagnostic diabetes in the general Korean population as well as the combined effects of exposure to mixed PFAS compounds.

Methods

We analyzed data from participants aged ≥19 years enrolled in the Korean National Environmental Health Survey Cycle 4 (2018–2020). Individuals diagnosed with diabetes were excluded to minimize potential bias. We identified cases of pre-diagnostic diabetes based on the HbA1c level ≥6.5% and prediabetes as HbA1c levels of 5.7–6.49%. Serum concentrations of PFAS, including perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), perfluorohexane sulfonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS), were quantified using high-performance liquid chromatography-tandem mass spectrometry. Survey-weighted logistic regression models were used to assess the relationships between PFAS levels and diabetes risk, adjusting for covariates. Additionally, Bayesian kernel machine regression (BKMR) was used to investigate the combined effects of exposure to mixed PFAS compounds.

Results

In the study population excluding participants with diagnosed diabetes (n = 2709), the prevalence of pre-diagnostic diabetes and prediabetes was 4.8% and 30.1%, respectively. Significant positive associations were found between serum PFHxS and PFOS quartiles and pre-diagnostic diabetes risk. Likewise, among those without diagnosed or pre-diagnostic diabetes (n = 2579), the highest quartiles of PFDeA, PFHxS, and PFOS and the overall PFAS level were associated with an increased risk of prediabetes compared with the lowest quartiles. BKMR analysis revealed a significant positive association between overall serum PFAS level and prediabetes risk, which was most marked for PFOS.

Conclusions

These findings highlight the potential health implications of PFAS exposure and prediabetes risk. Further research is needed to validate these associations and identify potential mechanistic pathways.

目的最近的流行病学研究对全氟烷基和多氟烷基物质(PFAS)与糖尿病之间的关系进行了调查,但结果并不确定。在这项横断面研究中,我们旨在探讨韩国普通人群中血清 PFAS 浓度与糖尿病前期和诊断前糖尿病患病率之间的关系,以及暴露于混合 PFAS 化合物的综合影响。为尽量减少潜在偏倚,我们排除了已确诊患有糖尿病的个体。我们根据 HbA1c 水平≥6.5% 确定了诊断前糖尿病病例,并根据 HbA1c 水平 5.7-6.49% 确定了糖尿病前期病例。采用高效液相色谱-串联质谱法对血清中的全氟辛酸 (PFOA)、全氟壬酸 (PFNA)、全氟癸酸 (PFDeA)、全氟己烷磺酸 (PFHxS) 和全氟辛烷磺酸 (PFOS) 等 PFAS 浓度进行了定量分析。采用调查加权逻辑回归模型评估全氟辛烷磺酸水平与糖尿病风险之间的关系,并对协变量进行调整。此外,还使用贝叶斯核机器回归(BKMR)来研究暴露于混合 PFAS 化合物的综合影响。结果在不包括已确诊糖尿病的参与者(n = 2709)的研究人群中,诊断前糖尿病和糖尿病前期的患病率分别为 4.8% 和 30.1%。血清全氟己烷磺酸和全氟辛烷磺酸四分位数与诊断前糖尿病风险之间存在显著的正相关。同样,在未确诊或诊断前患有糖尿病的人(n = 2579)中,PFDeA、PFHxS 和 PFOS 的最高四分位数以及 PFAS 的总体水平与最低四分位数相比,与糖尿病前期风险增加有关。BKMR 分析表明,血清中全氟辛烷磺酸的总体水平与糖尿病前期风险之间存在显著的正相关,其中以全氟辛烷磺酸最为明显。要验证这些关联并确定潜在的机理途径,还需要进一步的研究。
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引用次数: 0
Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones 全氟烷基和多氟烷基物质与母体第二孕期早期性类固醇激素的关系
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-04-23 DOI: 10.1016/j.ijheh.2024.114380
Diana C. Pacyga , George D. Papandonatos , Libeth Rosas , Jason Whalen , Sabrina Smith , June-Soo Park , Joseph C. Gardiner , Joseph M. Braun , Susan L. Schantz , Rita S. Strakovsky

Background/Aims

Pregnant women are exposed to persistent environmental contaminants, including per- and polyfluoroalkyl substances (PFAS) that disrupt thyroid function. However, it is unclear if PFAS alter maternal sex-steroid hormone levels, which support pregnancy health and fetal development.

Methods

In Illinois women with relatively high socioeconomic status (n = 460), we quantified perfluorononanoic (PFNA), perfluorooctane sulfonic (PFOS), perfluorooctanoic (PFOA), methyl-perfluorooctane sulfonamide acetic acid, perfluorohexanesulphonic (PFHxS), perfluorodecanoic (PFDeA), and perfluoroundecanoic (PFUdA) acid concentrations in fasting serum samples at median 17 weeks gestation, along with plasma progesterone, testosterone, and estradiol. We evaluated covariate-adjusted associations of ln-transformed hormones with each ln-transformed PFAS individually using linear regression and with the PFAS mixture using quantile-based g-computation (QGComp).

Results

Interquartile range (IQR) increases in PFOS were associated with higher progesterone (%Δ 3.0; 95%CI: −0.6, 6.6) and estradiol (%Δ: 8.1; 95%CI: 2.2, 14.4) levels. Additionally, PFHxS was positively associated with testosterone (%Δ: 10.2; 95%CI: 4.0, 16.7), whereas both PFDeA and PFUdA were inversely associated with testosterone (%Δ: −5.7; 95%CI: −10.3, −0.8, and %Δ: −4.1; 95%CI: −7.6, −0.4, respectively). The IQR-standardized PFAS mixture was not associated with progesterone (%Δ: 1.6; 95%CI: −5.8, 9.2), due equal partial positive (%Δ: 9.2; driven by PFOA) and negative (%Δ: −7.4; driven by PFOS) mixture associations. Similarly, the mixture was not associated with testosterone (%Δ: 5.3; 95%CI: −9.0, 20.1), due to similar partial positive (%Δ: 23.6; driven by PFHxS) and negative (%Δ: −17.4; driven by PFDeA) mixture associations. However, we observed a slightly stronger partial positive (%Δ: 25.6; driven by PFOS and PFUdA) than negative (%Δ: −16.3; driven by PFOA) association resulting in an overall non-significant positive trend between the mixture and estradiol (%Δ: 8.5; 95%CI: −3.7, 20.9).

Conclusion

PFAS mixture modeled using QGComp was not associated with maternal sex-steroid hormones due to potential opposing effects of certain PFAS. Additional prospective studies could corroborate these findings.

背景/目的孕妇暴露于持久性环境污染物中,包括会干扰甲状腺功能的全氟烷基和多氟烷基物质(PFAS)。然而,PFAS 是否会改变孕产妇的性类固醇激素水平尚不清楚,而性类固醇激素水平有助于孕期健康和胎儿发育。全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)、甲基全氟辛烷磺酰胺乙酸、全氟己烷磺酸(PFHxS)、全氟癸酸(PFDeA)和全氟十一烷酸(PFUdA)的浓度,以及血浆孕酮、睾酮和雌二醇的浓度。结果全氟辛烷磺酸在四分位数(IQR)范围内的增加与孕酮(%Δ 3.0;95%CI:-0.6,6.6)和雌二醇(%Δ:8.1;95%CI:2.2,14.4)水平的升高有关。此外,PFHxS 与睾酮呈正相关(%Δ:10.2;95%CI:4.0,16.7),而 PFDeA 和 PFUdA 与睾酮呈反相关(分别为%Δ:-5.7;95%CI:-10.3,-0.8 和%Δ:-4.1;95%CI:-7.6,-0.4)。经 IQR 标准化的 PFAS 混合物与孕酮无关(%Δ:1.6;95%CI:-5.8,9.2),这是因为部分正(%Δ:9.2;由 PFOA 引起)和部分负(%Δ:-7.4;由 PFOS 引起)的混合物相关性相同。同样,该混合物与睾酮(%Δ:5.3;95%CI:-9.0,20.1)也没有关联,原因是存在类似的部分正(%Δ:23.6;由 PFHxS 驱动)和负(%Δ:-17.4;由 PFDeA 驱动)混合物关联。然而,我们观察到部分正相关(%Δ:25.6;由 PFOS 和 PFUdA 驱动)略强于负相关(%Δ:-16.3;由 PFOA 驱动),导致混合物与雌二醇之间总体呈不显著的正相关趋势(%Δ:8.5;95%CI:-3.7, 20.9)。更多的前瞻性研究可以证实这些发现。
{"title":"Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones","authors":"Diana C. Pacyga ,&nbsp;George D. Papandonatos ,&nbsp;Libeth Rosas ,&nbsp;Jason Whalen ,&nbsp;Sabrina Smith ,&nbsp;June-Soo Park ,&nbsp;Joseph C. Gardiner ,&nbsp;Joseph M. Braun ,&nbsp;Susan L. Schantz ,&nbsp;Rita S. Strakovsky","doi":"10.1016/j.ijheh.2024.114380","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114380","url":null,"abstract":"<div><h3>Background/Aims</h3><p>Pregnant women are exposed to persistent environmental contaminants, including per- and polyfluoroalkyl substances (PFAS) that disrupt thyroid function. However, it is unclear if PFAS alter maternal sex-steroid hormone levels, which support pregnancy health and fetal development.</p></div><div><h3>Methods</h3><p>In Illinois women with relatively high socioeconomic status (n = 460), we quantified perfluorononanoic (PFNA), perfluorooctane sulfonic (PFOS), perfluorooctanoic (PFOA), methyl-perfluorooctane sulfonamide acetic acid, perfluorohexanesulphonic (PFHxS), perfluorodecanoic (PFDeA), and perfluoroundecanoic (PFUdA) acid concentrations in fasting serum samples at median 17 weeks gestation, along with plasma progesterone, testosterone, and estradiol. We evaluated covariate-adjusted associations of ln-transformed hormones with each ln-transformed PFAS individually using linear regression and with the PFAS mixture using quantile-based g-computation (QGComp).</p></div><div><h3>Results</h3><p>Interquartile range (IQR) increases in PFOS were associated with higher progesterone (%Δ 3.0; 95%CI: −0.6, 6.6) and estradiol (%Δ: 8.1; 95%CI: 2.2, 14.4) levels. Additionally, PFHxS was positively associated with testosterone (%Δ: 10.2; 95%CI: 4.0, 16.7), whereas both PFDeA and PFUdA were inversely associated with testosterone (%Δ: −5.7; 95%CI: −10.3, −0.8, and %Δ: −4.1; 95%CI: −7.6, −0.4, respectively). The IQR-standardized PFAS mixture was not associated with progesterone (%Δ: 1.6; 95%CI: −5.8, 9.2), due equal partial positive (%Δ: 9.2; driven by PFOA) and negative (%Δ: −7.4; driven by PFOS) mixture associations. Similarly, the mixture was not associated with testosterone (%Δ: 5.3; 95%CI: −9.0, 20.1), due to similar partial positive (%Δ: 23.6; driven by PFHxS) and negative (%Δ: −17.4; driven by PFDeA) mixture associations. However, we observed a slightly stronger partial positive (%Δ: 25.6; driven by PFOS and PFUdA) than negative (%Δ: −16.3; driven by PFOA) association resulting in an overall non-significant positive trend between the mixture and estradiol (%Δ: 8.5; 95%CI: −3.7, 20.9).</p></div><div><h3>Conclusion</h3><p>PFAS mixture modeled using QGComp was not associated with maternal sex-steroid hormones due to potential opposing effects of certain PFAS. Additional prospective studies could corroborate these findings.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140639226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outdoor air pollution as a risk factor for testing positive for SARS-CoV-2: A nationwide test-negative case-control study in the Netherlands 室外空气污染是 SARS-CoV-2 检测呈阳性的风险因素:荷兰全国性检测阴性病例对照研究
IF 6 2区 医学 Q1 Medicine Pub Date : 2024-04-22 DOI: 10.1016/j.ijheh.2024.114382
Mariana Simões , Jelle Zorn , Lenny Hogerwerf , Guus J.M. Velders , Lützen Portengen , Miriam Gerlofs-Nijland , Marieke Dijkema , Maciek Strak , José Jacobs , Joost Wesseling , Wilco J. de Vries , Suzanne Mijnen-Visser , Lidwien A.M. Smit , Roel Vermeulen , Lapo Mughini-Gras

Air pollution is a known risk factor for several diseases, but the extent to which it influences COVID-19 compared to other respiratory diseases remains unclear. We performed a test-negative case-control study among people with COVID-19-compatible symptoms who were tested for SARS-CoV-2 infection, to assess whether their long- and short-term exposure to ambient air pollution (AAP) was associated with testing positive (vs. negative) for SARS-CoV-2. We used individual-level data for all adult residents in the Netherlands who were tested for SARS-CoV-2 between June and November 2020, when only symptomatic people were tested, and modeled ambient concentrations of PM10, PM2.5, NO2 and O3 at geocoded residential addresses. In long-term exposure analysis, we selected individuals who did not change residential address in 2017–2019 (1.7 million tests) and considered the average concentrations of PM10, PM2.5 and NO2 in that period, and different sources of PM (industry, livestock, other agricultural activities, road traffic, other Dutch sources, foreign sources). In short-term exposure analysis, individuals not changing residential address in the two weeks before testing day (2.7 million tests) were included in the analyses, thus considering 1- and 2-week average concentrations of PM10, PM2.5, NO2 and O3 before testing day as exposure. Mixed-effects logistic regression analysis with adjustment for several confounders, including municipality and testing week to account for spatiotemporal variation in viral circulation, was used. Overall, there was no statistically significant effect of long-term exposure to the studied pollutants on the odds of testing positive vs. negative for SARS-CoV-2. However, significant positive associations of long-term exposure to PM10 and PM2.5 from specifically foreign and livestock sources, and to PM10 from other agricultural sources, were observed. Short-term exposure to PM10 (adjusting for NO2) and PM2.5 were also positively associated with increased odds of testing positive for SARS-CoV-2. While these exposures seemed to increase COVID-19 risk relative to other respiratory diseases, the underlying biological mechanisms remain unclear. This study reinforces the need to continue to strive for better air quality to support public health.

空气污染是多种疾病的已知风险因素,但与其他呼吸道疾病相比,空气污染对 COVID-19 的影响程度仍不清楚。我们对有 COVID-19 症状并接受了 SARS-CoV-2 感染检测的人进行了一项检测阴性病例对照研究,以评估他们长期和短期暴露于环境空气污染(AAP)是否与 SARS-CoV-2 检测阳性(与阴性)有关。我们使用了 2020 年 6 月至 11 月期间荷兰所有接受过 SARS-CoV-2 检测的成年居民的个人数据(当时只对有症状的人进行了检测),并对地理编码住宅地址的 PM10、PM2.5、NO2 和 O3 环境浓度进行了建模。在长期暴露分析中,我们选取了 2017-2019 年未更换居住地址的个人(170 万次检测),并考虑了该期间 PM10、PM2.5 和 NO2 的平均浓度,以及 PM 的不同来源(工业、畜牧业、其他农业活动、道路交通、其他荷兰来源、国外来源)。在短期暴露分析中,将检测日前两周内未更换居住地址的个人(270 万次检测)纳入分析范围,因此将检测日前一周和两周的 PM10、PM2.5、NO2 和 O3 平均浓度作为暴露量。采用混合效应逻辑回归分析,并对若干混杂因素(包括城市和检测周)进行调整,以考虑病毒循环的时空变化。总体而言,长期接触所研究的污染物对 SARS-CoV-2 检测呈阳性与阴性的几率没有明显的统计学影响。不过,长期暴露于国外和畜牧业污染源的 PM10 和 PM2.5 以及其他农业污染源的 PM10 会产生明显的正相关关系。短期接触 PM10(调整二氧化氮)和 PM2.5 也与 SARS-CoV-2 检测呈阳性的几率增加呈正相关。与其他呼吸道疾病相比,这些暴露似乎增加了 COVID-19 的风险,但其潜在的生物机制仍不清楚。这项研究加强了继续努力改善空气质量以支持公众健康的必要性。
{"title":"Outdoor air pollution as a risk factor for testing positive for SARS-CoV-2: A nationwide test-negative case-control study in the Netherlands","authors":"Mariana Simões ,&nbsp;Jelle Zorn ,&nbsp;Lenny Hogerwerf ,&nbsp;Guus J.M. Velders ,&nbsp;Lützen Portengen ,&nbsp;Miriam Gerlofs-Nijland ,&nbsp;Marieke Dijkema ,&nbsp;Maciek Strak ,&nbsp;José Jacobs ,&nbsp;Joost Wesseling ,&nbsp;Wilco J. de Vries ,&nbsp;Suzanne Mijnen-Visser ,&nbsp;Lidwien A.M. Smit ,&nbsp;Roel Vermeulen ,&nbsp;Lapo Mughini-Gras","doi":"10.1016/j.ijheh.2024.114382","DOIUrl":"https://doi.org/10.1016/j.ijheh.2024.114382","url":null,"abstract":"<div><p>Air pollution is a known risk factor for several diseases, but the extent to which it influences COVID-19 compared to other respiratory diseases remains unclear. We performed a test-negative case-control study among people with COVID-19-compatible symptoms who were tested for SARS-CoV-2 infection, to assess whether their long- and short-term exposure to ambient air pollution (AAP) was associated with testing positive (<em>vs</em>. negative) for SARS-CoV-2. We used individual-level data for all adult residents in the Netherlands who were tested for SARS-CoV-2 between June and November 2020, when only symptomatic people were tested, and modeled ambient concentrations of PM10, PM2.5, NO<sub>2</sub> and O<sub>3</sub> at geocoded residential addresses. In long-term exposure analysis, we selected individuals who did not change residential address in 2017–2019 (1.7 million tests) and considered the average concentrations of PM10, PM2.5 and NO<sub>2</sub> in that period, and different sources of PM (industry, livestock, other agricultural activities, road traffic, other Dutch sources, foreign sources). In short-term exposure analysis, individuals not changing residential address in the two weeks before testing day (2.7 million tests) were included in the analyses, thus considering 1- and 2-week average concentrations of PM10, PM2.5, NO<sub>2</sub> and O<sub>3</sub> before testing day as exposure. Mixed-effects logistic regression analysis with adjustment for several confounders, including municipality and testing week to account for spatiotemporal variation in viral circulation, was used. Overall, there was no statistically significant effect of long-term exposure to the studied pollutants on the odds of testing positive <em>vs</em>. negative for SARS-CoV-2. However, significant positive associations of long-term exposure to PM10 and PM2.5 from specifically foreign and livestock sources, and to PM10 from other agricultural sources, were observed. Short-term exposure to PM10 (adjusting for NO<sub>2</sub>) and PM2.5 were also positively associated with increased odds of testing positive for SARS-CoV-2. While these exposures seemed to increase COVID-19 risk relative to other respiratory diseases, the underlying biological mechanisms remain unclear. This study reinforces the need to continue to strive for better air quality to support public health.</p></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":null,"pages":null},"PeriodicalIF":6.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438463924000634/pdfft?md5=6e178ea0c6f623b6b93cfe4259c67ee8&pid=1-s2.0-S1438463924000634-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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International journal of hygiene and environmental health
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