International journal of hygiene and environmental health最新文献

{"title":"Influence of exposure to endocrine disruptors and other environmental chemicals on breast development in girls: A systematic review of human studies","authors":"Alicia Olivas-Martínez ,&nbsp;Paula Sol Ventura-Wischner ,&nbsp;Mariana F. Fernandez ,&nbsp;Carmen Freire","doi":"10.1016/j.ijheh.2024.114487","DOIUrl":"10.1016/j.ijheh.2024.114487","url":null,"abstract":"<div><h3>Background</h3><div>Age at thelarche has decreased over recent decades. This change in female puberty timing may be influenced by exposure to endocrine disrupting chemicals (EDCs) during critical periods of development.</div></div><div><h3>Objective</h3><div>To review the scientific literature for evidence on the association of exposure to EDCs and other environmental chemicals with the timing of thelarche in girls.</div></div><div><h3>Methods</h3><div>A systematic search for original peer-reviewed articles published up to July 2023 was conducted in three databases (Medline/PubMed, Scopus, and Web of Science), following the PECO strategy and PRISMA guidelines. The quality of evidence and reporting and the risk of bias were evaluated using GRADE, STROBE, and ROBINS-E tools.</div></div><div><h3>Results</h3><div>Out of 3094 articles retrieved in the search, 67 met the review inclusion criteria. Data from 10 out of the 14 studies offering high-quality suggest that <em>in utero</em> and/or childhood exposure to certain synthetic and natural chemicals is associated with earlier breast development in girls; 8 of these 10 studies described a relationship with exposure to organohalogenated compounds <em>in utero</em> and to phthalates in childhood.</div></div><div><h3>Conclusions</h3><div>This systematic review provides the first overview of available human data on the association of EDCs/environmental chemicals with the timing of thelarche. Further high-quality research is urgently needed to fully elucidate the influence of this exposure on breast development timing in girls.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114487"},"PeriodicalIF":4.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of particulate air pollution on BPDE-DNA adducts, telomere length, and mitochondrial DNA copy number in human exhaled breath condensate and BEAS-2B cells","authors":"Naruporn Pedklang ,&nbsp;Panida Navasumrit ,&nbsp;Chalida Chompoobut ,&nbsp;Jeerawan Promvijit ,&nbsp;Potchanee Hunsonti ,&nbsp;Mathuros Ruchirawat","doi":"10.1016/j.ijheh.2024.114488","DOIUrl":"10.1016/j.ijheh.2024.114488","url":null,"abstract":"<div><div>Traffic-related particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs) have been linked to respiratory diseases and cancer risk in humans. Genomic damage, including benzo[a]pyrene diolepoxide (BPDE)-DNA adducts as well as alterations in telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) are associated with respiratory diseases. This study aimed to investigate the association between exposure to traffic-related particulate pollutants and genomic damage in exhaled breath condensate (EBC) in human subjects and a bronchial epithelial cell line (BEAS-2B). Among the 60 healthy recruited subjects, residents living in high-traffic-congested areas were exposed to higher concentrations of PM_2.5 (1.66-fold, p &lt; 0.01), UFPs (1.79-fold, p &lt; 0.01), PM_2.5-PAHs (1.50-fold, p &lt; 0.01), and UFPs-PAHs (1.35-fold, p &lt; 0.05), than those in low-traffic-congested areas. In line with increased exposure to particulate air pollution, the high-traffic-exposed group had significantly increased BPDE-DNA adducts (1.40-fold, p &lt; 0.05), TL shortening (1.24-fold, p &lt; 0.05), and lower mtDNA-CN (1.38-fold, p &lt; 0.05) in EBC. The observations in the human study linking exposure to PM_2.5, UFPs, PM_2.5-PAHs, and UFPs-PAHs with the aforementioned biological effects were confirmed by an <em>in vitro</em> cell-based study, in which BEAS-2B cells were treated with diesel exhaust particulate matter (DEP) containing fine and ultrafine PM and PAHs. Increased BPDE-DNA adducts levels, shortened TL, and decreased mtDNA-CN were also found in treated BEAS-2B cells. The shortened TL and decreased mtDNA-CN were in part mediated by decreased transcript levels of h<em>TERT</em>, and <em>SIRT1</em>, which are involved in telomerase activity and mitochondrial biogenesis, respectively. These results suggest that exposure to traffic-related particulate pollutants can cause genomic instability in respiratory cells, which may increase the health risk of respiratory diseases and the development of cancer.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114488"},"PeriodicalIF":4.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper and zinc status in cord blood and breast milk and child's neurodevelopment at 18 months: Results of the Italian PHIME cohort","authors":"Fabiano Barbiero ,&nbsp;Valentina Rosolen ,&nbsp;Dario Consonni ,&nbsp;Marika Mariuz ,&nbsp;Maria Parpinel ,&nbsp;Luca Ronfani ,&nbsp;Liza Vecchi Brumatti ,&nbsp;Maura Bin ,&nbsp;Luigi Castriotta ,&nbsp;Francesca Valent ,&nbsp;D'Anna Little ,&nbsp;Janja Snoj Tratnik ,&nbsp;Darja Mazej ,&nbsp;Ingrid Falnoga ,&nbsp;Milena Horvat ,&nbsp;Fabio Barbone","doi":"10.1016/j.ijheh.2024.114485","DOIUrl":"10.1016/j.ijheh.2024.114485","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Trace elements, including zinc (Zn) and copper (Cu), although toxic at higher concentrations are known to play important roles in the maintenance of human health and neurodevelopment. Few epidemiological studies have investigated the association between prenatal or early postnatal Cu and Zn levels and child neurodevelopment. The aim of this research is to assess the association between child neurodevelopment at 18 months of age and cord blood and breast milk concentrations of Cu and Zn in Italian mother-child pairs enrolled in the Italian Northern Adriatic Cohort II (NAC-II), a part of the “Public health impact of long-term, low-level, mixed element exposure in susceptible population strata” project PHIME.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The study population consisted of 632 children, and their mothers, born within the NAC-II, who were tested with the Bayley Scales of Infant and Toddler Development third edition (BSID-III) at age 18 months. Cu and Zn concentrations were measured in cord blood and breast milk samples. Only children born at term (≥37 gestational week), who completed the BSID-III test and had at least 1 measure of Cu and Zn concentrations were included in the analysis. Information about socio-demographics and lifestyles were collected through questionnaires at different phases of follow-up. Cu and Zn concentrations were log&lt;sub&gt;2&lt;/sub&gt; transformed because of their skewed distribution. Multiple linear regression models were performed to study the association between each BSID-III composite score (cognitive, motor and language) and each metal concentration. Separate models were applied for each biological sample. The β coefficient (β) and its 95% confidence interval (95% CI) were estimated. Stratified analyses by child's sex were also conducted.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The mean ± standard deviation (SD) of cognitive, motor and language composite scores were respectively: 106 ± 8, 101 ± 5 and 97 ± 8. The mean ± SD of Cu and Zn concentrations (ng/g) were respectively 699.2 ± 129.0 and 2538 ± 589 in cord blood and 607 ± 498 and 3226 ± 1428 in breast milk. No association between metal concentration and cognitive composite score was found. A higher motor composite score was associated with higher Cu concentrations in cord blood (β = 4.31 95% CI 2.03; 6.59). No associations were found between language composite score and metal concentrations. The effect of Cu cord blood concentration on motor composite score was confirmed when stratified by sex: males (β = 5.49 95% CI 2.15; 8.36) and females (β = 3.11; 95% CI 0.00; 6.22). A direct association, in females only, was found between language composite score and Cu concentration in cord blood (β = 5.60 95% CI 0.63; 10.57) and in breast milk (β = 3.04 95% CI 1.06; 5.03), respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The results from this cohort study showed a strong direct association between prenatal Cu levels and child motor neurodevelopment","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114485"},"PeriodicalIF":4.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent organic pollutants among seafood processing workers in West Greenland","authors":"Maria Wielsøe ,&nbsp;Manhai Long ,&nbsp;Jakob Hjort Bønløkke ,&nbsp;Rossana Bossi ,&nbsp;Niels E. Ebbehøj ,&nbsp;Kurt Rasmussen ,&nbsp;Torben Sigsgaard ,&nbsp;Eva Cecilie Bonefeld-Jørgensen","doi":"10.1016/j.ijheh.2024.114484","DOIUrl":"10.1016/j.ijheh.2024.114484","url":null,"abstract":"<div><div>The Greenlandic population is highly exposed to persistent organic pollutants (POPs) through the consumption of traditional marine food, including marine mammals. Central to Greenland's economy and cultural identity, the fishing industry employes about 15% of the working population.</div><div>This study investigated POP exposure, including polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and per- and polyfluoroalkyl substances (PFASs), among seafood processing workers at the Greenlandic west coast. We examined determinants for the POPs including age, smoking habits, ethnicity, and working place. Additionally, we explored the association between POPs and the prevalence of asthma, allergy, and lung function.</div><div>With samples taken during 2016–2018, the study encompassed 382 workers, primarily of Inuit descent (93%), employed across three large factories located in Nuuk, Sisimiut, and Ilulissat, four smaller factories in settlements (Kangaatsiaq, Ikerasaarsuk, Sarfannguaq, Qeqertarsuaq), and four factory trawlers. Data collected include clinical examinations, questionnaires on ethnicity, occupational exposure status, health indicators, and smoking habits, and serum selenium and POP analyses. We used ANCOVA with adjustment for relevant confounders to assess differences in POPs between groups (e.g. ethnic groups and working place), and multiple linear and logistic regressions were used to assess associations between POPs and lung function, allergy and asthma.</div><div>Significant differences in POPs were observed among ethnic groups; Faroese workers had the highest concentrations of lipophilic POPs (lipPOPs; PCBs and OCPs), while Inuit workers exhibited highest PFASs. All subsequent analyses were focused on the Inuit workers (n = 337). The PFASs were significantly higher in workers at small factories, followed by large factories and trawlers, whereas no differences were seen for lipPOPs. The differences between the working places were most likely due to differences in lifestyle and diet, but occupational exposures cannot be excluded.</div><div>LipPOP and PFAS concentrations associated positively with selenium, and PFASs positively associated with lung function. However, upon adjustment of selenium, the associations between PFASs and lung function became non-significant and attenuated towards null. No significant associations were found between POPs and the prevalence of asthma or allergy.</div><div>Compared to the general population in the same area and period, the seafood processing workers exhibited 2–6 times higher POP levels. The higher exposure level among seafood processing workers, as well as the difference across workplaces, underscore the need for further investigation of environmental and occupational sources of POPs in this population. These findings may contribute to future public health strategies and regulatory measures to reduce POP exposure in Arctic populations.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114484"},"PeriodicalIF":4.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational phthalate exposure and behavioral problems in preschool-aged children with increased likelihood of autism spectrum disorder","authors":"Jeong Weon Choi ,&nbsp;Deborah H. Bennett ,&nbsp;Antonia M. Calafat ,&nbsp;Daniel J. Tancredi ,&nbsp;Meghan Miller ,&nbsp;Rebecca J. Schmidt ,&nbsp;Hyeong-Moo Shin","doi":"10.1016/j.ijheh.2024.114483","DOIUrl":"10.1016/j.ijheh.2024.114483","url":null,"abstract":"<div><h3>Background</h3><div>Experimental studies have shown associations between gestational phthalate exposure and behavioral problems among offspring; however, epidemiological evidence is still mixed. This study aims to investigate whether gestational phthalate exposure is associated with behavioral problems in preschool-aged children.</div></div><div><h3>Methods</h3><div>Participants include 178 mother-child pairs from MARBLES (Markers of Autism Risk in Babies – Learning Early Signs), a cohort with high familial likelihood of autism spectrum disorder (ASD). We quantified 14 phthalate metabolites in multiple maternal urine samples collected during the 2nd and 3rd trimesters. Preschool behavior problems were assessed using the Child Behavioral Checklist (CBCL), a standardized instrument for evaluating behavior problems of children aged 1.5–5 years. To examine associations of CBCL scores with both individual phthalate biomarker concentrations and their mixture, we used negative binomial regression and weighted quantile sum regression.</div></div><div><h3>Results</h3><div>Overall, maternal phthalate biomarker concentrations were not associated with child behavior problems. Monoisobutyl phthalate (MiBP) concentrations were inversely associated with child anxious/depressed symptoms and somatic complaints. Mono-hydroxy-isobutyl phthalate (MHiBP) and monobenzyl phthalate (MBzP) were also inversely associated with somatic complaints. When assessing trimester-specific associations, more behavior problems were associated with the 2nd trimester biomarker concentrations: mono(3-carboxypropyl) phthalate (MCPP) and monocarboxyisononyl phthalate (MCNP) were positively associated with somatic complaints. All associations became non-significant after false discovery rate correction. No association between a mixture of phthalates and CBCL scores was found.</div></div><div><h3>Conclusions</h3><div>Our study observed no clear evidence of gestational phthalate exposure on child behavior problems. However, our findings based on the biomonitoring assessment of multiple samples per participant could improve our understanding of gestational phthalate exposure in association with behavior problems in preschool-aged children.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114483"},"PeriodicalIF":4.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-trends of blood lead levels from 2020 to 2023 in pregnant and breastfeeding women from Adjara, Georgia—A birth registry-based study","authors":"Charlotta Rylander ,&nbsp;Nona Ephadze ,&nbsp;Tinatin Manjavidze ,&nbsp;Erik Eik Anda ,&nbsp;Nino Dzotsenidze ,&nbsp;Rusudan Shavishvili","doi":"10.1016/j.ijheh.2024.114482","DOIUrl":"10.1016/j.ijheh.2024.114482","url":null,"abstract":"<div><h3>Background</h3><div>In response to substantial lead exposure, the autonomous republic of Adjara in Georgia initiated complementary blood lead level (BLL) testing for pregnant women as part of their antenatal care services in 2020.</div></div><div><h3>Objectives</h3><div>To study the background BLLs in pregnant and breastfeeding women in Adjara and explore the time-trends of BLLs from September 2020 to July 2023.</div></div><div><h3>Methods</h3><div>We used data on BLLs during pregnancy or postpartum from the lead screening program in Adjara, combined with data from the Georgian Birth Registry, totaling 9,510 women. To study the temporal changes in BLLs, we used independent samples t-tests and chi-square tests.</div></div><div><h3>Results</h3><div>In 2020, the mean (standard deviation [SD]) BLL was 8.8 (5.4) μg/dL, declining annually by 1.0–2.2 μg/dL to reach 3.6 (2.5) μg/dL in 2023. The prevalence of pregnant women with BLLs ≥3.5, ≥5.0, and ≥10.0 μg/dL also decreased from 2020 to 2023. Specifically, 21.2% of women in their first trimester had BLLs ≥10 μg/dL in 2020, compared with 2.3% in 2023. Similarly, 73.5% had BLLs ≥5.0 μg/dL in 2020, which declined to 20.4% in 2023. Lastly, 89.1% had BLLs ≥3.5 μg/dL in 2020, decreasing to 38.6% in 2023.</div></div><div><h3>Discussion</h3><div>In 2023, nearly 40% of women in their first trimester had BLLs of ≥3.5 μg/dL, a level considered the reference value in the United States (US) and corresponding to the 97.5th percentile among US children. From 2020 to 2023, the mean BLL in pregnant women decreased by 59%, accompanied by a considerable decline in the prevalence of women with BLLs ≥3.5, ≥5.0, and ≥10.0 μg/dL. Despite the encouraging downward trend in BLLs throughout the study period, our data indicate that a considerable number of fetuses continue to be exposed to harmful levels of lead and that lead exposure remains a significant public health challenge in Adjara.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114482"},"PeriodicalIF":4.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of urinary 3-hydroxybenzo(a)Pyrene (3-OHBaP) and trans-anti-7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydrobenzo(a)Pyrene (TetraolBaP) as biomarkers of exposure to carcinogenic BaP","authors":"Marie Marquès,&nbsp;Renaud Persoons","doi":"10.1016/j.ijheh.2024.114476","DOIUrl":"10.1016/j.ijheh.2024.114476","url":null,"abstract":"<div><h3>Introduction</h3><div>Biomonitoring of exposure to carcinogenic Benzo(a)Pyrene is generally based on measurement of urinary 3-hydroxybenzo(a)pyrene (3-OHBaP), but its analysis is complex and only reflects the BaP detoxification pathway. TetraolBaP, another BaP metabolite resulting from the metabolic activation pathway, is now available but has not yet been studied in occupational settings or compared with 3-OHBaP.</div></div><div><h3>Methods</h3><div>Biomonitoring was carried out on 118 subjects working in the aluminium smelting industry. 3 urine samples were collected from each subject at the beginning and end of the working week. Pyrene metabolite (1-hydroxypyrene) and the two BaP biomarkers (3-OHBaP and TetraolBaP) were analysed using LC-Fluorescence and GC-NCI-MS-MS.</div></div><div><h3>Results</h3><div>The workers studied were found to be highly exposed, with 1-OHP and 3-OHBaP frequently exceeding maximum recommended values in occupational settings. Maximum concentrations were measured at end of shift+16h for all biomarkers, highlighting dermal exposure and/or temporary storage. Correlations were strong between 1-OHP and 3-OHBaP (r = 0.68–0.75) as well as between 3-OHBaP and TetraolBaP (r = 0.67–0.78), and moderate between 1-OHP and TetraolBaP (r = 0.59–0.76). While TetraolBaP levels were higher at low PAH exposures, TetraolBaP increased much more slowly at high exposures, indicating progressive saturation of the bioactivation pathway. The [3-OHBaP]/[TetraolBaP] ratio was found to be significantly lower in chronically exposed workers. Urinary TetraolBaP levels corresponding to 1-OHP (2.5 μg/L or 1 μmol/mol creatinine) or 3-OHBaP (0.4 nmol/mol creatinine) guidance values were found to range between 0.84 and 0.95 nmol/mol creatinine.</div></div><div><h3>Conclusions</h3><div>TetraolBaP, resulting from carcinogenic BaP's metabolic activation pathway, was shown to be a diagnostically specific and sensitive biomarker for determining subjects' toxic internal exposure to PAHs in different contexts (occupational settings, environment) and assessing health risks.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114476"},"PeriodicalIF":4.5,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to chlorpyrifos of French children from the Elfe cohort","authors":"Elisa Thépaut ,&nbsp;Cleo Tebby ,&nbsp;Michèle Bisson ,&nbsp;Céline Brochot ,&nbsp;Aude Ratier ,&nbsp;Cécile Zaros ,&nbsp;Stéphane Personne ,&nbsp;Karen Chardon ,&nbsp;Florence Zeman","doi":"10.1016/j.ijheh.2024.114480","DOIUrl":"10.1016/j.ijheh.2024.114480","url":null,"abstract":"<div><h3>Background</h3><div>The organophosphate pesticide chlorpyrifos was widely used in the European Union before its ban in 2020 and was associated with neurodevelopmental disorders. However, within the concept of Developmental Origins of Health and Disease, <em>in utero</em> exposure to chlorpyrifos can lead to neurodevelopmental effects in developing children.</div></div><div><h3>Objective</h3><div>The aim of this study was to estimate fetal exposure to chlorpyrifos using biomonitoring data measured in Elfe pregnant women and a physiologically based pharmacokinetic (PBPK) approach and compare exposure to toxicological reference values.</div></div><div><h3>Methods</h3><div>A pregnancy-PBPK model was developed based on an existing adult chlorpyrifos model and a new toxicological reference value was proposed for neurodevelopmental effects. The pregnant women exposure was estimated based on dialkylphosphate (DAP) levels in urine assuming constant exposure to chlorpyrifos and compared to both the existing toxicological reference value and the new proposed draft toxicological reference value. Fetal internal concentrations in target tissues were then predicted using the developed pregnancy-PBPK model. Urinary concentrations of the chlorpyrifos-specific metabolite (TCPy) were also predicted for comparison with other biomonitoring data.</div></div><div><h3>Results</h3><div>The median daily exposure to chlorpyrifos for the French pregnant women from the Elfe cohort was estimated at 6.3x10⁻⁴ μg/kg body weight/day. The predicted urinary excretion of TCPy, the chlorpyrifos-specific metabolite, is in the same range as observed in other European cohorts (mean: 2.13 μg/L). Predicted brain chlorpyrifos levels were similar in pregnant women and their fetus and were 10-fold higher than the predicted blood chlorpyrifos levels. It was estimated that 6% and 20% of the pregnant women population had been exposed to levels exceeding the general population and draft toxicological reference values, respectively.</div></div><div><h3>Conclusions</h3><div>Prenatal exposure to chlorpyrifos was estimated for the French population based on data from the Elfe cohort. Internal chlorpyrifos concentrations in target tissues (brain and blood) were predicted for fetuses at the end of the pregnancy. Under a conservative assumption, a small percentage of the population was identified as being exposed to levels exceeding the toxicological reference values.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114480"},"PeriodicalIF":4.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressive symptoms modify the association between noise and adiposity biomarkers: Evidence from a population study of Czech adults","authors":"Anna Bartoskova Polcrova ,&nbsp;Andrea Dalecka ,&nbsp;Katarzyna Kordas ,&nbsp;Daniel Szabo ,&nbsp;Juan Pablo Gonzalez Rivas ,&nbsp;Martin Bobak ,&nbsp;Hynek Pikhart","doi":"10.1016/j.ijheh.2024.114481","DOIUrl":"10.1016/j.ijheh.2024.114481","url":null,"abstract":"<div><h3>Objective</h3><div>Environmental noise exposure is associated with adiposity. However, less is known about the individual vulnerability to environmental noise in abnormal adiposity development, particularly in relation to mental health. This study investigated the association between environmental noise exposure and four adiposity biomarkers and tested the moderation effect of depressive symptoms.</div></div><div><h3>Methods</h3><div>A cross-sectional population-based sample of 2031 participants aged 25–64 years (54.70% women) was drawn from the Kardiovize study in 2013. Global combined (road, railway, and airport) L_den (day-evening-night) noise exposures were obtained from the geographical prediction modelling for the 2nd report of Strategic noise mapping in the Czech Republic (2012). Four adiposity biomarkers (BMI, body fat percentage, waist circumference, and visceral fat area) were assessed. Depressive symptoms were measured by PHQ-9. Linear regression was used to estimate the separate effects of quartiles of noise exposure and depressive symptoms on adiposity biomarkers and to examine the interaction between noise exposure and depressive symptoms.</div></div><div><h3>Results</h3><div>The average noise exposure was 53.79 dB, ranging from 42.50 dB to 66.97 dB. All biomarkers were significantly elevated in the highest noise exposure quartile (&gt;56 dB), compared to the lowest quartile (&lt;51 dB) (p &lt; 0.05). The association between noise and adiposity biomarkers was modified by presence of depressive symptoms; the increase in all adiposity biomarkers in the highest quartile of noise was significantly larger among subjects with moderate to severe depressive symptoms (p &lt; 0.005).</div></div><div><h3>Conclusion</h3><div>The study confirmed the association between environmental noise exposure and several adiposity measures. The association was stronger in the presence of depressive symptoms.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114481"},"PeriodicalIF":4.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current exposure to environmental pollutants in the general adult population of Kinshasa, Democratic Republic of Congo (DRC): A cross-sectional study","authors":"Trésor Bayebila Menanzambi ,&nbsp;Catherine Pirard ,&nbsp;Cédric Ilunga wa Kabuaya ,&nbsp;Lievin's-Corneille Mputu Malolo ,&nbsp;Manix Mayangi Makola ,&nbsp;Fridolin Kodondi Kule-Koto ,&nbsp;Jean Nsangu Mpasi ,&nbsp;Roland Marini Djang'eing'a ,&nbsp;Jérémie Mbinze Kindenge ,&nbsp;Corinne Charlier ,&nbsp;Patrice Dufour","doi":"10.1016/j.ijheh.2024.114479","DOIUrl":"10.1016/j.ijheh.2024.114479","url":null,"abstract":"<div><h3>Background</h3><div>Environmental pollution is a serious public health problem because of its adverse effects on both human health and biodiversity. In Western countries, many human biomonitoring (HBM) studies are conducted to assess population exposure to pollutants. In contrast, the number of HBM studies in Africa is very low.</div></div><div><h3>Objective</h3><div>To measure contamination by arsenic, lead, 4,4′-dichlorodiphenyldichloroethylene (4,4′-DDE) and polychlorobiphenyls (PCBs) in the adult population of Kinshasa and to identify the susceptible population.</div></div><div><h3>Methods</h3><div>In the present work, we measured the contamination by arsenic in urine and lead in blood and by 4,4′-DDE and polychlorobiphenyls (PCBs) in serum in samples collected from 151 volunteers recruited in Kinshasa, the capital of the Democratic Republic of Congo (DRC).</div></div><div><h3>Results</h3><div>The PCBs 180, -153 and −138 were detected in most samples with median concentrations of 0.04, 0.05 and 0.04 ng/ml, respectively. The median concentration of 4,4′-DDE was 0.83 ng/ml and 12.7% of our population showed contamination above the threshold of 3.675 ng/ml, which is associated with a significantly higher risk of cancer. Arsenic concentrations were also high (median: 48.1 μg/L in urine). Finally, exposure to lead is problematic: the median blood concentration was 54.9 μg/L, which is above the thresholds proposed by the WHO and the US CDC (50 μg/L and 35 μg/L respectively) to initiate clinical intervention, and 12.6% of the population had a lead level above 100 μg/L, which is associated with several health outcomes.</div></div><div><h3>Conclusions</h3><div>Our results highlight the need for further HBM studies in Africa and should encourage the authorities of the DRC to implement laws and regulations to reduce pollution and population exposure.</div></div>","PeriodicalId":13994,"journal":{"name":"International journal of hygiene and environmental health","volume":"263 ","pages":"Article 114479"},"PeriodicalIF":4.5,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}