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Validation of Two Rapid Serological Tests for Human Brucellosis Detection 两种人类布鲁氏菌病快速血清学检测方法的验证
Pub Date : 2019-01-04 DOI: 10.18311/IJMDS/2019/22802
O. Genç, Y. Çetinkol, Yas O Buyuktan�r, N. Yurdusev
As brucellosis have several non-specific clinical phases, the search for reliable diagnosis of the disease is necessary. Therefore, for serological determination of brucellosis, rapid immunofiltration tests designated as ERIFA and NERIFA and ELISAs were developed and evaluated for diagnostic purposes. The sera were collected from Clinical Microbiology Department of Kars State Hospital between 2007 and 2009. These sera were used for determination of sensitivity of ELISAs, ERIFA and NERIFA in comparison to rose bengal test, Brucellacapt and serum agglutination tests. In the study, highest sensitivity was detected by ELISA, ERIFA and NERIFA, respectively. Specificity was highest with ELISA as 95.2% and with both ERIFA and NERIFA as 92.9% and the lowest was with RBT as 90.5%. When two ELISAs were compared based on the IgG sensitivity, there was no difference (p0.05) when IgM was accepted as a criteria for comparison. The current study reports the first evaluation of ERIFA and NERIFA in human beings. It is concluded that the RIFA models can be accepted as an ancillary test for diagnosis of human brucellosis in endemic countries.
由于布鲁氏菌病有几个非特异性临床阶段,因此有必要寻求对该疾病的可靠诊断。因此,对于布鲁氏菌病的血清学测定,开发了ERIFA和NERIFA等快速免疫过滤试验以及elisa,并对其诊断目的进行了评估。血清采集于卡尔斯州立医院临床微生物科2007 - 2009年。这些血清用于测定elisa、ERIFA和NERIFA与玫瑰孟加拉试验、布鲁氏杆菌和血清凝集试验的敏感性。ELISA、ERIFA和NERIFA检测灵敏度最高。ELISA的特异性最高,为95.2%,ERIFA和NERIFA的特异性均为92.9%,RBT的特异性最低,为90.5%。以IgG敏感性比较两种elisa时,以IgM作为比较标准无差异(p0.05)。本研究报道了ERIFA和NERIFA在人体中的首次评价。结论是,在布鲁氏菌病流行国家,可以接受RIFA模型作为诊断人布鲁氏菌病的辅助试验。
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引用次数: 1
Submental Endotracheal Intubation for Maxillofacial Surgery: A Report of Two Cases 颏下气管插管用于颌面外科:附2例报告
Pub Date : 2019-01-04 DOI: 10.18311/IJMDS/2019/22086
Adetayo Ma, Oguntade Fao, Salami Of, Ogundare Ea, Ademakinwa Oo
The technique of submental endotracheal intubation has been established as a safe alternative to tracheostomy and can be utilized when oro-tracheal and naso-tracheal routes of intubation are not ideal for orofacial surgical intervention. The technique is simple and avoids the complications of tracheostomy. We present 2 cases of adults with orofacial injuries requiring surgery. Both cases were managed using the submental method of intubation and the procedure was well tolerated. There were no perioperative complications and patients were discharged on the fifth postoperative day.
颏下气管插管技术已被确立为一种安全的替代气管切开术的技术,当经口气管和鼻气管插管途径不适合进行口面部手术干预时,可以使用该技术。该技术简单,避免了气管切开术的并发症。我们提出2例成人口面部损伤需要手术。两例均采用颏下插管方法,手术耐受性良好。无围手术期并发症,术后第5天出院。
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引用次数: 0
Primary Adenocarcinoma of Jejunum: A Case Report 原发性空肠腺癌1例报告
Pub Date : 2019-01-04 DOI: 10.18311/IJMDS/2019/22817
Vaneeta Bhardwar, Neha Batra, S. Goyal, K. Masih
Malignancy of small intestine is a very rare entity. Duodenum is the most common site for intestinal malignancy. The lesions present with stricture mostly. Small intestinal strictures distal to the duodenum are relatively inaccessible by endoscopy. This leads to difficulty in definitive preoperative diagnosis. The symptoms in case of jejunal malignancy are very nonspecific and a high index of suspicion is required for diagnosis.
小肠恶性肿瘤是非常罕见的疾病。十二指肠是肠道恶性肿瘤最常见的部位。病变多表现为狭窄。十二指肠远端的小肠狭窄在内镜下是相对难以接近的。这导致术前确诊困难。空肠恶性肿瘤的症状是非特异性的,诊断需要高度的怀疑指数。
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引用次数: 0
Effectiveness of Use of Ultraviolet Sanitizing Devices for Reduction of Bacterial Colonies on Toothbrushes 使用紫外线消毒装置减少牙刷细菌菌落的效果
Pub Date : 2018-07-01 DOI: 10.18311/ijmds/2018/20073
Burhanuddin Daeng Daeng Pasiga
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引用次数: 1
Increasing Caesarean Rates: Analysis of Indications and Possible Interventions 增加剖宫产率:适应症分析和可能的干预措施
Pub Date : 2018-07-01 DOI: 10.18311/IJMDS/2018/20642
Shail Kaur
Background: The alarming increase in caesarean section rates worldwide has led to a shift of focus to caesarean section rates and indications for caesarean section. The main objective of the study was to analyse the indications for caesarean section with the aim of finding viable interventions which could help decrease the caesarean rates. Methods: A retrospective study from 1st January 2017 to 31st December 2017 was conducted in which we analysed patient records of those delivering in unit III of our institute. Analysis of patient records was done and indication for caesarean was analysed. Results: A total of 496 women delivered in our unit in 2017, of these, 303 (61.09%) had a vaginal delivery and 193 (38.91%) had caesarean section. 108 patients (21.77%) had a history of at least one previous caesarean section and of these 94 (87.03%) underwent a repeat caesarean section. The primary caesarean section rate was 25.51%. Section was done for breech presentation in eleven primigravidae (5.7% of sections) and in fifteen multigravidae (7.77% of sections) including those with a previous section. Four patients had multiple pregnancy (2.04% of all sections). Eleven patients had a preterm section (5.7% of sections). Conclusion: In order to decrease caesarean rates the group that requires most focus is those in whom a primary section is being done. Few patients who have undergone at least one prior surgery are willing to take the risk inherent to a trial of labour (TOLAC). Classification and reporting of caesarean section according to the Robson ten point criteria will help in a better understanding of the indication, comparison and auditing and help to establish guidelines that can help decrease the caesarean rates.
背景:世界范围内剖宫产率的惊人增长导致了人们对剖宫产率和剖宫产指征的关注。本研究的主要目的是分析剖宫产的指征,以寻找可行的干预措施,有助于降低剖宫产率。方法:2017年1月1日至2017年12月31日进行回顾性研究,分析我院第三单元分娩的患者记录。分析病例记录,分析剖宫产指征。结果:2017年我院共分娩496例产妇,其中阴道分娩303例(61.09%),剖宫产193例(38.91%)。108例(21.77%)患者既往至少有一次剖宫产史,其中94例(87.03%)再次剖宫产。初次剖宫产率为25.51%。对11个初孕科(5.7%)和15个多孕科(7.77%)(包括前一段)的臀位表现进行了切片。多胎妊娠4例(2.04%)。早产11例(占剖宫产的5.7%)。结论:为了降低剖宫产率,最需要关注的群体是那些正在做一次剖宫产的人。很少有接受过至少一次手术的患者愿意承担分娩试验(TOLAC)所固有的风险。根据罗布森十点标准对剖宫产进行分类和报告将有助于更好地理解指征、比较和审计,并有助于制定有助于降低剖宫产率的指导方针。
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引用次数: 1
Prevalence of Risk Factors of Non-Communicable Diseases in a Rural Population of Eastern Uttar Pradesh 北方邦东部农村人口中非传染性疾病风险因素的流行情况
Pub Date : 2018-07-01 DOI: 10.18311/IJMDS/2018/20122
D. Agarwal, Siraj Ahmad, J. Singh, Mukesh Shukla, B. Kori, Aditi Garg
Introduction: Over past few decade morbidities and mortalities associated with NCDs (Non-Communicable Diseases) leads to a significant loss of productive life years both in developed and developing countries. Therefore, the present study was done to determine the prevalence of common risk factors for major NCDs in a rural population of Barabanki district in eastern Uttar Pradesh. Materials and Methods: The present cross-sectional study was conducted in Satrikh block of Barabanki district. Multistage sampling was used for enrolment of the study subjects. A totalof 1824 participants aged ≥25 years were enrolled in the study. WHO STEPs- wise tool was used to collect information on behavioural risk factors like tobacco use, diet, alcohol useand associated anthropometric indices were measured. Results: Prevalence of tobacco smoking, smokeless tobacco products use, alcohol consumption, less than five servings of fruits/vegetables, more than five grams of salt intake and overweight/obesity was found to be 26.2%, 27.08%, 24.1%, 91.61%, 10.9% and 34.86% respectively. Individuals with age more than 35 years, male subjects, illiterates and those who belonged to scheduled castes/tribes were significantly (p<0.05) more predisposed to both smoked tobacco as well as smokeless tobacco use and alcohol consumption.Consumption of alcohol was significantly (p<0.05) higher among employed groups who belonged to upper and upper middle class while tobacco consumption was more prevalent in lower socioeconomic group. Consumption of salt more than 5 grams per day was significantly higher among individuals in elder age group (35-65 days), among females, those who were literate, those who belonged to other backward castes and among government employees. Conclusion: The study revealed high prevalence of non-communicable disease risk factors among adults. This indicates towards need of prompt community based preventive measures and control strategies to lower the forthcoming consequences of NCDs.
导言:在过去几十年中,与非传染性疾病相关的发病率和死亡率导致发达国家和发展中国家生产性生命年的大量损失。因此,本研究旨在确定北方邦东部巴拉班基地区农村人口中主要非传染性疾病的常见危险因素的流行情况。材料与方法:本横断面研究在Barabanki区Satrikh街区进行。采用多阶段抽样方法对研究对象进行登记。共有1824名年龄≥25岁的参与者入组研究。使用世卫组织STEPs- wise工具收集有关吸烟、饮食、饮酒等行为风险因素的信息,并测量相关的人体测量指数。结果:吸烟、使用无烟烟草制品、饮酒、水果/蔬菜少于5份、盐摄入量大于5克和超重/肥胖的患病率分别为26.2%、27.08%、24.1%、91.61%、10.9%和34.86%。年龄大于35岁的个体、男性受试者、文盲和属于计划种姓/部落的个体吸烟、无烟烟草使用和酒精消费的倾向显著(p<0.05)。上层和上层中产阶级就业群体的酒精消费显著(p<0.05)高,而下层社会经济群体的烟草消费更为普遍。在老年人(35-65天)、女性、受过教育的人、属于其他落后种姓的人以及政府雇员中,每天超过5克的盐摄入量明显更高。结论:该研究揭示了成人中非传染性疾病风险因素的高患病率。这表明需要迅速采取以社区为基础的预防措施和控制战略,以降低非传染性疾病即将产生的后果。
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引用次数: 1
Study on Gender Specific Variability of Gastrointestinal, Genitourinary and Depression Related Non Motor Symptoms of Parkinson Disease 帕金森病胃肠道、泌尿生殖系统及抑郁相关非运动症状的性别差异研究
Pub Date : 2018-07-01 DOI: 10.18311/IJMDS/2018/21429
A. Dehiyan, Sarabjeet Singh
Introduction: Parkinson’s disease is a second most common neurodegenerative disorder after Alzheimer’s disease. It affects 1% of population over age of 50 years. Three main features of PD is asymmetric onset of bradykinesia, rigidity and resting tremors. Non motor symptoms are common in patients of Parkinson’s Disease. These remain undiagnosed most of the time. Aim and Objectives: To analyse gender specific, age related and demographic variability of non motor symptoms (Gastrointestinal, genitourinary and depression related symptoms) of Parkinson’s disease. Material and Methods: Present study Included 100 cases (65 Males and 35 Females) of Parkinson’s disease presenting at department of neurology, Dayanand Medical College and hospital, Ludhiana. 30 questionnaire of non motor symptoms in hindi and Punjabi were given to patients. Gender, age, duration of non motor symptoms, Parkinson’s phenotype and complete demographic profile of each patient taken into account for study. Thereafter results were statistically analysed for all parameters. Conclusion: It is concluded that mean age and duration of non-motor symptoms were higher in males as compared to females. GI symptoms amongst non-motor symptoms were commonest and amongst GI symptoms constipation was most common and there was positive correlation of H&Y with age and non motor symptoms especially gastrointestinal, genitourinary and depression related symptoms.
简介:帕金森病是继阿尔茨海默病之后第二常见的神经退行性疾病。50岁以上人口中有1%患有此病。PD的三个主要特征是运动迟缓、僵硬和静息性震颤的不对称发病。非运动症状在帕金森病患者中很常见。大多数时候,这些疾病仍未得到诊断。目的和目的:分析帕金森病非运动症状(胃肠道、泌尿生殖系统和抑郁相关症状)的性别特异性、年龄相关性和人口统计学变异性。材料与方法:选取卢迪亚纳市达亚南医学院及医院神经内科收治的帕金森病患者100例(男65例,女35例),对患者进行印地语和旁遮普语非运动症状问卷调查。研究考虑了每个患者的性别、年龄、非运动症状持续时间、帕金森症表型和完整的人口统计资料。然后对所有参数的结果进行统计分析。结论:男性非运动症状的平均年龄和持续时间高于女性。在非运动症状中,胃肠道症状是最常见的在胃肠道症状中,便秘是最常见的H&Y与年龄和非运动症状呈正相关尤其是胃肠道,泌尿生殖系统和抑郁相关症状。
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引用次数: 1
Pulmonary Sarcomatoid Carcinoma 肺肉瘤样癌
Pub Date : 2018-07-01 DOI: 10.18311/IJMDS/2018/19898
Malvika Sharma
Pulmonary Sarcomatoid Carcinoma (PSC) is a poorly differentiated NSCLC with sarcoma like differentiation (spindle/giant cell) or a component of sarcoma (malignant bone/cartilage/skeletal muscle). WHO grading 2015, classifies sarcomatoid ca into five histological types: pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma and pulmonary blastoma.
肺肉瘤样癌(PSC)是一种低分化的非小细胞肺癌,具有肉瘤样分化(梭形细胞/巨细胞)或肉瘤的组成部分(恶性骨/软骨/骨骼肌)。WHO分级2015将类肉瘤癌分为5种组织学类型:多形性癌、梭形细胞癌、巨细胞癌、癌肉瘤和肺母细胞瘤。
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引用次数: 0
Drug Delivery Through Blood Brain Barrier: Taming the Bottleneck in CNS Therapeutics 通过血脑屏障给药:克服中枢神经系统治疗的瓶颈
Pub Date : 2018-07-01 DOI: 10.18311/IJMDS/2018/20037
V. Sehgal, Ritika Singla
Although many agents have therapeutic potentials for Central Nervous System (CNS) diseases, few of these agents have been clinically used because of the brain barriers. Physiological barriers like the blood-brain barrier and blood-cerebrospinal fluid barrier as well as various efflux transporter proteins make the entry of drugs into the central nervous system very difficult. Different strategies for efficient CNS delivery have been studied. This review presents the current approaches to facilitate penetration across these barriers for enhanced drug delivery to the CNS.
虽然许多药物对中枢神经系统(CNS)疾病具有治疗潜力,但由于脑屏障的原因,这些药物很少用于临床。血脑屏障、血脑脊液屏障等生理屏障以及各种外排转运蛋白使得药物进入中枢神经系统非常困难。研究了不同的有效中枢神经传递策略。这篇综述介绍了目前的方法,以促进穿透这些障碍,以增强药物输送到中枢神经系统。
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引用次数: 1
Multiple Calcified Scrotal Sebaceous Cysts:A Rare Case Presentation 多发阴囊皮脂腺囊肿钙化一例
Pub Date : 2018-01-09 DOI: 10.18311/ijmds/2018/18918
Randeep Lamba, M. Uppal, S. Mittal, M. Kohli, Jagpreet Singh
A sebaceous cyst is a retention cyst. The classical management of scrotal sebaceous cysts is complete surgical excision and in the current era and as expected from the patient from the doctor and as the duty of the doctor, excellent outcome, minimal morbidity with good cosmetic results.
皮脂腺囊肿是一种潴留囊肿。阴囊皮脂腺囊肿的经典治疗方法是完全的手术切除,在当今时代,这是病人对医生的期望,也是医生的职责,结果很好,发病率低,美容效果好。
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引用次数: 1
期刊
International Journal of Medical and Dental Sciences
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