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Microbially mediated phenolic catabolites exert differential genoprotective activities in normal and adenocarcinoma cell lines. 微生物介导的酚类代谢产物在正常细胞系和腺癌细胞系中发挥不同的基因保护活性。
IF 3.9 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-11 DOI: 10.1080/09637486.2024.2397055
Brian Óg Murphy,Cheryl Latimer,Sara Dobani,L Kirsty Pourshahidi,Massimilano Fontana,Nigel G Ternan,Gordon McDougall,Ian Rowland,Gema Pereira-Caro,Kieran M Tuohy,Daniele Del Rio,Tahani M Almutairi,Alan Crozier,Nenad Naumovski,Chris I R Gill
Age-associated decline of nuclear factor erythroid 2-related factor 2 (Nrf2) activity and DNA repair efficiency leads to the accumulation of DNA damage and increased risk of cancer. Understanding the mechanisms behind increased levels of damaged DNA is crucial for developing interventions to mitigate age-related cancer risk. Associated with various health benefits, (poly)phenols and their microbially mediated phenolic catabolites represent a potential means to reduce DNA damage. Four colonic-microbiota-derived phenolic catabolites were investigated for their ability to reduce H2O2-induced oxidative DNA damage and modulate the Nrf2-Antixoidant Response Element (ARE) pathway, in normal (CCD 841 CoN) and adenocarcinoma (HT29) colonocyte cell lines. Each catabolite demonstrated significant (p < .001) genoprotective activity and modulation of key genes in the Nrf2-ARE pathway. Overall, the colon-derived phenolic metabolites, when assessed at physiologically relevant concentrations, reduced DNA damage in both normal and adenocarcinoma colonic cells in response to oxidative challenge, mediated in part via upregulation of the Nrf2-ARE pathway.
与年龄相关的核因子红细胞2相关因子2(Nrf2)活性和DNA修复效率的下降会导致DNA损伤的积累和癌症风险的增加。了解受损 DNA 水平增加背后的机制,对于制定干预措施以降低与年龄相关的癌症风险至关重要。与各种健康益处相关的(多)酚及其微生物介导的酚类代谢产物是减少 DNA 损伤的一种潜在手段。我们研究了四种结肠微生物区系衍生的酚类代谢产物,以了解它们在正常(CCD 841 CoN)和腺癌(HT29)结肠细胞系中减少 H2O2 诱导的 DNA 氧化损伤和调节 Nrf2-Antixoidant Response Element (ARE) 通路的能力。每种代谢产物都具有显著的基因保护活性(p < .001),并能调节 Nrf2-ARE通路中的关键基因。总之,当以生理相关浓度进行评估时,结肠衍生的酚类代谢物可减少正常和腺癌结肠细胞在氧化挑战下的 DNA 损伤,部分是通过上调 Nrf2-ARE通路介导的。
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引用次数: 0
Nutritional value of cereal-based gluten-free products and comparison to that of gluten containing counterparts in the Greek market. 谷物类无麸质产品的营养价值以及与希腊市场上含麸质同类产品的营养价值比较。
IF 3.9 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-09 DOI: 10.1080/09637486.2024.2397057
Eirini Bathrellou,Meropi D Kontogianni
Nutritional value of the Gluten-free products (GFPs) has been highly debated. Aiming to assess the nutritional value of the cereal-based GFPs in the Greek market, information from the nutritional label and the ingredients list, of all GFPs and their gluten-containing (GC) counterparts available in a supermarket offering the greatest availability in the capital of Greece, were recorded. The sample consisted of 913 products: 351 GFPs and 562 GCPs, classified into 12 categories (e.g., breads, melbas, breakfast cereals, cereal bars, pasta, flours, cookies). With minor exceptions, comparisons among all food categories regarding nutrient profile and nutritional claims showed mixed results, though supporting an overly comparable nutritional profile of the GFPs. Still, a quarter of all GFPs presented an unhealthy nutritional profile. The findings of the present study are highly in agreement with those of relevant studies in the literature, that do not support an inferior nutritional profile compared to GC counterparts.
无麸质产品(GFP)的营养价值一直备受争议。为了评估希腊市场上以谷物为基础的无麸质食品的营养价值,我们记录了希腊首都一家供应量最大的超市中所有无麸质食品及其含麸质(GC)同类产品的营养标签和配料表信息。样本包括 913 种产品:351 种 GFP 和 562 种 GCP,分为 12 个类别(如面包、麦芽糖、早餐谷物、谷物棒、面食、面粉、饼干)。除少数例外情况外,所有食品类别之间在营养成分和营养声称方面的比较结果参差不齐,但都支持普通食品添加剂的营养成分具有很强的可比性。不过,仍有四分之一的普通食品添加剂的营养成分不健康。本研究的结果与文献中的相关研究结果高度一致,这些研究结果并不支持普通食品的营养成分低于普通食品。
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引用次数: 0
Effects of rhamnose consumption on bone mineral density in healthy postmenopausal women: a randomised, placebo-controlled, double-blind, parallel-group pilot study. 食用鼠李糖对绝经后健康女性骨矿物质密度的影响:一项随机、安慰剂对照、双盲、平行组试验研究。
IF 3.9 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-09 DOI: 10.1080/09637486.2024.2397056
Naoko Suzuki,Takafumi Imada,Naoki Ueshima,Hideyuki Orikoshi,Tsuyoshi Takara
Preventing the decrease in bone mineral density (BMD) is significant for postmenopausal women. We previously discovered that rhamnose, a deoxy monosaccharide used as a food additive, could suppress bone resorption; however, studies confirming this effect in postmenopausal women are lacking. Therefore, this pilot study aimed to explore whether rhamnose could help maintain BMD via bone resorption suppression in postmenopausal women. The participants consumed either 1.0 or 0.5 g/day of rhamnose or placebo for 24 weeks, and BMD (lumbar spine and femur) and bone turnover markers were measured. After 24 weeks, the group consuming rhamnose 1.0 g/day exhibited a significantly higher BMD of the lumbar spine than the placebo group. Furthermore, the levels of tartrate-resistant acid phosphatase 5b, a bone resorption marker, were significantly lower in both rhamnose groups. These results indicated that rhamnose might contribute to the maintenance of BMD by suppressing bone resorption in healthy postmenopausal women (UMIN000046570).
防止骨矿物质密度(BMD)下降对绝经后妇女意义重大。我们以前曾发现鼠李糖(一种用作食品添加剂的脱氧单糖)可以抑制骨吸收,但目前还缺乏在绝经后妇女中证实这种作用的研究。因此,本试验研究旨在探讨鼠李糖是否能通过抑制绝经后妇女的骨吸收来帮助维持骨密度。参与者每天摄入 1.0 克或 0.5 克鼠李糖或安慰剂,为期 24 周,并测量了 BMD(腰椎和股骨)和骨转换标志物。24 周后,每天摄入鼠李糖 1.0 克的组的腰椎骨密度明显高于安慰剂组。此外,两个鼠李糖组的抗酒石酸磷酸酶 5b (一种骨吸收标志物)水平都明显降低。这些结果表明,鼠李糖可抑制绝经后健康妇女的骨吸收,从而有助于维持骨密度(UMIN000046570)。
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引用次数: 0
Validation of the food inflation impact on consumer behavior scale: a comparative measurement instrument with focus on food security. 验证食品通胀对消费者行为的影响量表:以食品安全为重点的比较测量工具。
IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1080/09637486.2024.2379819
Mehmet Haydaroğlu, Pelin Bilgiç

This study aimed to compare the change in consumer behaviour in the face of high inflation with respect to food security in the Turkish population by developing a 3-factor The Impact of Food Inflation on Consumer Behaviour (IFI-ConB) scale. Item generation and expert evaluation, item purification by preliminary application, and final administration were conducted. The moderate to severe food insecure individuals exhibited a higher inflation impact score on food consumption patterns, food shopping behaviours, and food purchasing motives factors compared to secure to mild insecure individuals. A positive correlation was found between the inflation impact score by IFI-ConB and the price motive for food choice. The primary food choice motive was health among the secure to mild insecure individuals, while for the moderate to severe food insecure individuals, it was price. The findings indicate that food insecure individuals are more affected by high food inflation compared to food secure individuals.

本研究旨在通过编制三因素的 "食品通胀对消费者行为的影响 "量表(IFI-ConB),比较土耳其人在面临高通胀时与食品安全有关的消费行为变化。我们进行了项目生成和专家评估、通过初步应用对项目进行提纯以及最终施测。与安全至轻度缺乏粮食安全的个体相比,中度至重度缺乏粮食安全的个体在食品消费模式、食品购物行为和食品购买动机因子上表现出更高的通货膨胀影响得分。研究发现,IFI-ConB 的通货膨胀影响得分与食品选择的价格动机之间存在正相关。安全至轻度缺乏安全感人群的主要食品选择动机是健康,而中度至重度缺乏安全感人群的主要食品选择动机是价格。研究结果表明,与粮食有保障的人相比,粮食无保障的人受高食品通胀的影响更大。
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引用次数: 0
Dietary glycemic index and glycemic load predict longitudinal change in glycemic and cardio-metabolic biomarkers among old diabetic adults living in a resource-poor country. 膳食血糖指数和血糖负荷可预测生活在资源贫乏国家的老年糖尿病患者血糖和心血管代谢生物标志物的纵向变化。
IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-01 Epub Date: 2024-07-01 DOI: 10.1080/09637486.2024.2368843
Yen Nhi Hoang, Trong Hung Nguyen, Dang Khanh Ngan Ho, Chyi-Huey Bai, Wen-Ling Lin, Huong Duong Phan, Hoang Hiep Phan, Ngoc Luong Tran, Jung-Su Chang

This study aims to investigate longitudinal associations between the dietary glycemic index (GI) and glycemic load (GL) and changes in glycemic and cardio-metabolic outcomes. A 28-month retrospective cohort study included 110 Vietnamese diabetic patients, collecting their dietary GI and GL values along with blood biochemical data from baseline 24-h dietary recall and medical records. Latent class growth modelling identified three distinct HbA1c trajectories during the follow-up period, with 51% of patients achieving good glycemic control. The adjusted linear mixed-effect model showed that 1 unit increase in logarithms in dietary GL was associated with a 0.14% increase in the log-HbA1c. Among poorly controlled diabetic patients, baseline GL values were positively correlated with increases in HbA1c; GI showed effects on changes in fasting plasma glucose and the triglyceride-glucose (TyG) index. No significant association was observed in patients with good glycemic control.

本研究旨在探讨膳食血糖生成指数(GI)和血糖生成负荷(GL)与血糖生成和心血管代谢结果变化之间的纵向联系。这项为期 28 个月的回顾性队列研究纳入了 110 名越南糖尿病患者,收集了他们的膳食血糖生成指数(GI)和血糖负荷(GL)值,以及基线 24 小时膳食回忆和医疗记录中的血液生化数据。潜类增长模型确定了随访期间三种不同的 HbA1c 变化轨迹,其中 51% 的患者实现了良好的血糖控制。调整后的线性混合效应模型显示,膳食 GL 对数每增加 1 个单位,对数 HbA1c 就会增加 0.14%。在控制不佳的糖尿病患者中,基线 GL 值与 HbA1c 的增加呈正相关;GI 对空腹血浆葡萄糖和甘油三酯-葡萄糖(TyG)指数的变化有影响。在血糖控制良好的患者中没有观察到明显的相关性。
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引用次数: 0
Weight, habitual fibre intake, and microbiome composition predict tolerance to fructan supplementation. 体重、习惯性纤维摄入量和微生物组组成可预测对果糖补充剂的耐受性。
IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI: 10.1080/09637486.2024.2372590
Jeffrey Letourneau, Benjamin C Neubert, Diana Dayal, Verónica M Carrion, Heather K Durand, Eric P Dallow, Sharon Jiang, Michelle Kirtley, Geoffrey S Ginsburg, P Murali Doraiswamy, Lawrence A David

Fructans are commonly used as dietary fibre supplements for their ability to promote the growth of beneficial gut microbes. However, fructan consumption has been associated with various dosage-dependent side effects. We characterised side effects in an exploratory analysis of a randomised trial in healthy adults (n = 40) who consumed 18 g/day inulin or placebo. We found that individuals weighing more or habitually consuming higher fibre exhibited the best tolerance. Furthermore, we identified associations between gut microbiome composition and host tolerance. Specifically, higher levels of Christensenellaceae R-7 group were associated with gastrointestinal discomfort, and a machine-learning-based approach successfully predicted high levels of flatulence, with [Ruminococcus] torques group and (Oscillospiraceae) UCG-002 sp. identified as key predictive taxa. These data reveal trends that can help guide personalised recommendations for initial inulin dosage. Our results support prior ecological findings indicating that fibre supplementation has the greatest impact on individuals whose baseline fibre intake is lowest.

果聚糖通常被用作膳食纤维补充剂,因为它能促进有益肠道微生物的生长。然而,果聚糖的摄入与各种剂量依赖性副作用有关。我们对健康成年人(n = 40)每天摄入 18 克菊粉或安慰剂的随机试验进行了探索性分析,分析了副作用的特征。我们发现,体重较重或习惯性摄入较高纤维的人耐受性最好。此外,我们还发现了肠道微生物群组成与宿主耐受性之间的关联。具体来说,较高水平的克里斯滕森菌科 R-7 群与胃肠道不适有关,基于机器学习的方法成功地预测了高水平的胀气,[反刍球菌] torques 群和(震旦梭菌科)UCG-002 sp.被确定为关键的预测类群。这些数据揭示的趋势有助于指导个性化的菊粉初始剂量建议。我们的研究结果支持之前的生态学研究结果,即纤维补充剂对基线纤维摄入量最低的个体影响最大。
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引用次数: 0
Maternal fat intake in pregnancy and risk of depressive symptoms in Japanese adolescents: the Kyushu Okinawa Maternal and Child Health Study. 母亲孕期脂肪摄入量与日本青少年出现抑郁症状的风险:九州冲绳母婴健康研究。
IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-01 Epub Date: 2024-06-26 DOI: 10.1080/09637486.2024.2370351
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Masashi Arakawa

The current prebirth cohort study investigated the association between maternal intake of specific types of fatty acids during pregnancy and adolescent depressive symptoms based on the Center for Epidemiologic Studies Depression Scale. Subjects were 873 mother-child pairs. Dietary intake during the preceding month was assessed using a self-administered diet history questionnaire. The risk of depressive symptoms was 23.3% among the 873 adolescents at 13 years of age. Higher maternal saturated fatty acid intake during pregnancy was independently associated with a reduced risk of depressive symptoms in adolescents. Maternal intake of total fat, monounsaturated fatty acids, n-3 polyunsaturated fatty acids, α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, n-6 polyunsaturated fatty acids, linoleic acid, arachidonic acid and cholesterol during pregnancy was not significantly related to depressive symptoms in adolescents. Higher maternal intake of saturated fatty acids during pregnancy may be inversely associated with adolescent depressive symptoms.

这项产前队列研究根据流行病学研究中心抑郁量表(Center for Epidemiologic Studies Depression Scale),调查了母亲在怀孕期间摄入特定类型脂肪酸与青少年抑郁症状之间的关系。研究对象为 873 对母子。前一个月的饮食摄入量通过自填式饮食史问卷进行评估。在 873 名 13 岁的青少年中,出现抑郁症状的风险为 23.3%。孕期母体饱和脂肪酸摄入量越高,青少年出现抑郁症状的风险就越低。母亲在怀孕期间摄入的总脂肪、单不饱和脂肪酸、n-3 多不饱和脂肪酸、α-亚麻酸、二十碳五烯酸、二十二碳六烯酸、n-6 多不饱和脂肪酸、亚油酸、花生四烯酸和胆固醇与青少年抑郁症状无明显关系。孕妇在怀孕期间摄入较多的饱和脂肪酸可能与青少年抑郁症状成反比。
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引用次数: 0
Causal benefits of 25 dietary intakes on epigenetic ageing: a Mendelian randomisation study. 25 种膳食摄入量对表观遗传老化的因果效益:孟德尔随机研究。
IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-01 Epub Date: 2024-07-17 DOI: 10.1080/09637486.2024.2379817
Kaixi Ding, Wei Jiang, Shangjing Wuke, Ming Lei

DNA methylation GrimAge acceleration (DMGA) and intrinsic epigenetic age acceleration (IEAA) are important physiological markers for assessing the ageing process. Evidence from cross-sectional studies suggests that some dietary intake is associated with DMGA and IEAA. However, the causal relationship between them has yet to be elucidated. This Mendelian randomisation study uses genetic variants associated with different dietary intakes as instrumental variables to explore the causal benefits of multiple dietary intakes on DMGA and IEAA. Cheese intake, dark chocolate intake, average weekly red wine intake, dried fruit intake, fresh fruit intake, porridge intake, cereal intake, and liver intake had a negative causal association with DMGA, and poultry intake and doughnut intake had a positive causal association with DMGA (p < 0.05). Muesli and bran cereal intake had a negative causal association with IEAA, and pineapple intake had a positive causal association with IEAA (p < 0.05). Dietary intake positively causally associated with IEAA or DMGA may have accelerated biological ageing; conversely, dietary intake negatively causally associated with IEAA or DMGA may have contributed to delaying biological ageing. Based on genetic evidence, this study demonstrated some significant causal benefits of dietary intake on DMGA and IEAA, suggesting the possibility of intervening in DNA methylation acceleration and epigenetic age acceleration by adjusting these food intakes, thereby promoting health and delaying ageing. However, the findings of this study are exploratory and preliminary and need to be supported and validated by evidence from further clinical studies and mechanistic studies.

DNA甲基化年龄加速(DMGA)和内在表观遗传年龄加速(IEAA)是评估衰老过程的重要生理标志。横断面研究的证据表明,某些饮食摄入与 DMGA 和 IEAA 有关。然而,它们之间的因果关系尚未得到阐明。这项孟德尔随机研究利用与不同膳食摄入量相关的基因变异作为工具变量,探讨多种膳食摄入量对 DMGA 和 IEAA 的因果关系。奶酪摄入量、黑巧克力摄入量、每周平均红葡萄酒摄入量、干果摄入量、新鲜水果摄入量、粥类摄入量、谷物摄入量和肝脏摄入量与 DMGA 存在负因果关系,而家禽摄入量和甜甜圈摄入量与 DMGA 存在正因果关系(P p
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引用次数: 0
Food security in Ukraine today's conditions. 当今乌克兰的粮食安全状况。
IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-01 Epub Date: 2024-07-21 DOI: 10.1080/09637486.2024.2379825
Serhii Kvasha, Paolo Andrei, Maria Cecilia Mancini, Vitalii Vakulenko

The system-forming element of national security is food security, which guarantees effective management of the food system, ensuring the food needs of the appropriate quantity and quality of each country's citizen. Despite the significant potential of the agricultural sector, which forms the basis of food security, the need to analyse the state of food security in the current situation is due to military operations on the territory of Ukraine, which led to its negative global results. In this regard, the need to develop effective strategies and legal regulation is essential to ensure national and global food security, which in turn requires coordination of efforts of all countries and international organisations through international cooperation. The study aims to establish a pattern regarding the current state of food security by analysing the impact of availability, access, usefulness and stability of food supply on food security. Research methods: comparative analysis; taxonomic analysis; systematisation, generalisation. The survey found that Ukraine's position in the Global Food Security Index (FSI) among 113 countries in 2022 worsened by 13 points, where the worst indicators for domestic food security are sustainability and adaptability (43.5 points out of 100 and 94th place globally) and economic affordability of food (48.1 points out of 100 and 93rd place in the world). It was found that the actual consumption of vegetables, melons, potatoes, and oil in 2021 was slightly higher than the rational norm, indicating sufficient consumption of these products, while the actual consumption of products that are lower than the rational norm includes meat and meat products, milk and dairy products, fish and fish products, and fruits, berries, and grapes. It has been determined that since 2016, the number of kilocalories in the daily diet of the population of Ukraine has not reached the minimum norm of consumption of basic foodstuffs for the working population. It has been established that in 2020 and 2021, the value of the taxonomic indicator for assessing the level of food security (I) has been decreasing, i.e. the distance to the reference vector has been increasing, which indicates a decrease in the level of food security. The forecasting results suggest a downward trend in the food security index for the period 2022-2027, and there is an urgent need to take measures to eliminate this trend and improve the value of the index, which is extremely important for the security of the state, especially in times of war.

国家安全的系统构成要素是粮食安全,它保证粮食系统的有效管理,确保每个国家的公民对粮食的适当数量和质量的需求。尽管构成粮食安全基础的农业部门潜力巨大,但由于乌克兰领土上的军事行动导致了消极的全球结果,因此有必要分析当前形势下的粮食安全状况。在这方面,必须制定有效的战略和法律条例,以确保国家和全球粮食安全,这反过来又需要通过国际合作协调所有国家和国际组织的努力。本研究旨在通过分析粮食供应的可获得性、可获取性、有用性和稳定性对粮食安全的影响,建立有关粮食安全现状的模式。研究方法:比较分析、分类分析、系统化、概括化。调查发现,2022 年乌克兰在 113 个国家中的全球粮食安全指数(FSI)排名下降了 13 位,其中国内粮食安全指标最差的是可持续性和适应性(满分 43.5 分,全球排名第 94 位)以及粮食的经济承受能力(满分 48.1 分,全球排名第 93 位)。调查发现,2021 年蔬菜、瓜类、薯类、油类的实际消费量略高于合理常量,说明这些产品的消费量充足,而低于合理常量的产品包括肉及肉制品、奶及奶制品、鱼及鱼制品、水果、浆果、葡萄等。经确定,自 2016 年起,乌克兰居民日常饮食中的千卡热量未达到劳动人口基本食品消费的最低标准。已确定在 2020 年和 2021 年,用于评估粮食安全水平的分类指标值(I)一直在下降,即与参考矢量的距离一直在增加,这表明粮食安全水平在下降。预测结果表明,2022-2027 年期间粮食安全指数呈下降趋势,迫切需要采取措施消除这一趋势并提高指数值,这对国家安全极为重要,尤其是在战争时期。
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引用次数: 0
Identification of the serum metabolites associated with cow milk consumption in Chinese Peri-/Postmenopausal women. 鉴定中国围绝经期/绝经后妇女血清中与饮用牛奶有关的代谢物
IF 3.5 2区 农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Pub Date : 2024-09-01 Epub Date: 2024-06-25 DOI: 10.1080/09637486.2024.2366223
Bo Tian, Lu-Lu Xu, Lin-Dong Jiang, Xu Lin, Jie Shen, Hui Shen, Kuan-Jui Su, Rui Gong, Chuan Qiu, Zhe Luo, Jia-Heng Yao, Zhuo-Qi Wang, Hong-Mei Xiao, Li-Shu Zhang, Hong-Wen Deng

Cow milk consumption (CMC) and downstream alterations of serum metabolites are commonly considered important factors regulating human health status. Foods may lead to metabolic changes directly or indirectly through remodelling gut microbiota (GM). We sought to identify the metabolic alterations in Chinese Peri-/Postmenopausal women with habitual CMC and explore if the GM mediates the CMC-metabolite associations. 346 Chinese Peri-/Postmenopausal women participants were recruited in this study. Fixed effects regression and partial least squares discriminant analysis (PLS-DA) were applied to reveal alterations of serum metabolic features in different CMC groups. Spearman correlation coefficient was computed to detect metabolome-metagenome association. 36 CMC-associated metabolites including palmitic acid (FA(16:0)), 7alpha-hydroxy-4-cholesterin-3-one (7alphaC4), citrulline were identified by both fixed effects regression (FDR < 0.05) and PLS-DA (VIP score > 2). Some significant metabolite-GM associations were observed, including FA(16:0) with gut species Bacteroides ovatus, Bacteroides sp.D2. These findings would further prompt our understanding of the effect of cow milk on human health.

食用牛奶(CMC)和血清代谢物的下游变化通常被认为是调节人类健康状况的重要因素。食物可能直接或间接地通过重塑肠道微生物群(GM)导致代谢变化。我们试图确定有习惯性 CMC 的中国围绝经期/绝经后妇女的代谢改变,并探讨肠道微生物群是否介导了 CMC 与代谢物之间的关联。本研究共招募了 346 名中国围绝经期/绝经后妇女。采用固定效应回归和偏最小二乘法判别分析(PLS-DA)揭示不同CMC组血清代谢特征的变化。斯皮尔曼相关系数用于检测代谢组与基因组之间的关联。通过固定效应回归(FDR < 0.05)和 PLS-DA(VIP 评分 > 2),确定了 36 种与 CMC 相关的代谢物,包括棕榈酸(FA(16:0))、7alpha-羟基-4-胆固醇-3-酮(7alphaC4)和瓜氨酸。观察到一些重要的代谢物-基因组关联,包括 FA(16:0)与肠道物种 Bacteroides ovatus 和 Bacteroides sp.D2 的关联。这些发现将进一步促使我们了解牛奶对人类健康的影响。
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引用次数: 0
期刊
International Journal of Food Sciences and Nutrition
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